Developmental Cell

Article	Citations
Cigarette Smoke Exposure and Inflammatory Signaling Increase the Expression of the SARS-CoV-2 Receptor ACE2 in the Respiratory Tract	316
Thriving under Stress: How Plants Balance Growth and the Stress Response	304
Phase Separation and Neurodegenerative Diseases: A Disturbance in the Force	256
ORF3a of the COVID-19 virus SARS-CoV-2 blocks HOPS complex-mediated assembly of the SNARE complex required for autolysosome formation	249
Lipid metabolism in cancer: New perspectives and emerging mechanisms	218
Phase Separation in Membrane Biology: The Interplay between Membrane-Bound Organelles and Membraneless Condensates	185
Distinct contributions of partial and full EMT to breast cancer malignancy	177
Single-Cell Sequencing of Developing Human Gut Reveals Transcriptional Links to Childhood Crohn’s Disease	174
Single-Cell Analysis of Human Retina Identifies Evolutionarily Conserved and Species-Specific Mechanisms Controlling Development	173
The Tubulin Code in Microtubule Dynamics and Information Encoding	172
Single-Cell RNA Sequencing of Human, Macaque, and Mouse Testes Uncovers Conserved and Divergent Features of Mammalian Spermatogenesis	158
ERK-Mediated Mechanochemical Waves Direct Collective Cell Polarization	157
Quality control of the mitochondrion	155
A single-cell analysis of the Arabidopsis vegetative shoot apex	151
A Single-Cell Transcriptomic Atlas of Human Skin Aging	150
Dietary Lipids Induce Ferroptosis in Caenorhabditiselegans and Human Cancer Cells	141
Hematopoietic Stem Cell Metabolism during Development and Aging	131
Matrix Rigidity Controls Epithelial-Mesenchymal Plasticity and Tumor Metastasis via a Mechanoresponsive EPHA2/LYN Complex	130
Single-cell RNA sequencing of developing maize ears facilitates functional analysis and trait candidate gene discovery	129
CRISPR-Cas13d Induces Efficient mRNA Knockdown in Animal Embryos	128
Single-cell resolution of lineage trajectories in the Arabidopsis stomatal lineage and developing leaf	127
Niches that regulate stem cells and hematopoiesis in adult bone marrow	126
Single-Cell Transcriptomic Analyses of the Developing Meninges Reveal Meningeal Fibroblast Diversity and Function	121
Cellular Mechanisms and Regulation of Quiescence	117
Cancer Cells Don’t Live Alone: Metabolic Communication within Tumor Microenvironments	116

Surviving and thriving: How plants perceive and respond to temperature stress	116
A single-cell Arabidopsis root atlas reveals developmental trajectories in wild-type and cell identity mutants	114
ORF3a of SARS-CoV-2 promotes lysosomal exocytosis-mediated viral egress	108
Chromosomal instability accelerates the evolution of resistance to anti-cancer therapies	105
NPC1-mTORC1 Signaling Couples Cholesterol Sensing to Organelle Homeostasis and Is a Targetable Pathway in Niemann-Pick Type C	105
Mechanical Adaptability of Tumor Cells in Metastasis	104
Lipid metabolism and lipid signals in aging and longevity	104
Microtubule Nucleation Properties of Single Human γTuRCs Explained by Their Cryo-EM Structure	100
Intestinal Regeneration: Regulation by the Microenvironment	99
Comprehensive Endogenous Tagging of Basement Membrane Components Reveals Dynamic Movement within the Matrix Scaffolding	99
Mechanosensing through Direct Binding of Tensed F-Actin by LIM Domains	95
The single-cell stereo-seq reveals region-specific cell subtypes and transcriptome profiling in Arabidopsis leaves	94
Collective ERK/Akt activity waves orchestrate epithelial homeostasis by driving apoptosis-induced survival	91
Epithelial plasticity, epithelial-mesenchymal transition, and the TGF-β family	90
A Dual Protein-mRNA Localization Screen Reveals Compartmentalized Translation and Widespread Co-translational RNA Targeting	89
The GSK3-like Kinase BIN2 Is a Molecular Switch between the Salt Stress Response and Growth Recovery in Arabidopsis thaliana	89
Gene copy-number changes and chromosomal instability induced by aneuploidy confer resistance to chemotherapy	89
Emerging Roles for Phase Separation in Plants	86
Gli1+ Periodontium Stem Cells Are Regulated by Osteocytes and Occlusal Force	85
Chromatin Accessibility Dynamics and a Hierarchical Transcriptional Regulatory Network Structure for Plant Somatic Embryogenesis	84
Enhancer grammar in development, evolution, and disease: dependencies and interplay	84
OsNSUN2-Mediated 5-Methylcytosine mRNA Modification Enhances Rice Adaptation to High Temperature	83
Integration of Hippo-YAP Signaling with Metabolism	82
Differentiation of Human Intestinal Organoids with Endogenous Vascular Endothelial Cells	81
S-acylation controls SARS-CoV-2 membrane lipid organization and enhances infectivity	81
Mechanical Tension Promotes Formation of Gastrulation-like Nodes and Patterns Mesoderm Specification in Human Embryonic Stem Cells	80
Liquid-Liquid Phase Separation in Neuronal Development and Synaptic Signaling	79
Buckling of an Epithelium Growing under Spherical Confinement	78
Metabolites Regulate Cell Signaling and Growth via Covalent Modification of Proteins	78
The Lysosome at the Intersection of Cellular Growth and Destruction	77
Inducible Stem-Cell-Derived Embryos Capture Mouse Morphogenetic Events In Vitro	77
Diverse nitrogen signals activate convergent ROP2-TOR signaling in Arabidopsis	77
N6-methyladenosine modification of MALAT1 promotes metastasis via reshaping nuclear speckles	76
Tissue mechanics in stem cell fate, development, and cancer	76
Quiescent human glioblastoma cancer stem cells drive tumor initiation, expansion, and recurrence following chemotherapy	76
Autophagy and organelle homeostasis in cancer	75
ER-phagy responses in yeast, plants, and mammalian cells and their crosstalk with UPR and ERAD	74
Histone H3 lysine 4 trimethylation in sperm is transmitted to the embryo and associated with diet-induced phenotypes in the offspring	74
Dek Modulates Global Intron Retention during Muscle Stem Cells Quiescence Exit	72
Mitochondrial-derived vesicles compensate for loss of LC3-mediated mitophagy	70
Genetic Fate Mapping of Transient Cell Fate Reveals N-Cadherin Activity and Function in Tumor Metastasis	70
Next-Generation Lineage Tracing and Fate Mapping to Interrogate Development	70
A census of the lung: CellCards from LungMAP	70
Live Visualization of ERK Activity in the Mouse Blastocyst Reveals Lineage-Specific Signaling Dynamics	69
Cell-Cycle-Dependent ERK Signaling Dynamics Direct Fate Specification in the Mammalian Preimplantation Embryo	69
Fibroblast dedifferentiation as a determinant of successful regeneration	68
Robustness of epithelial sealing is an emerging property of local ERK feedback driven by cell elimination	67
Single-Cell RNA Sequencing of the Cynomolgus Macaque Testis Reveals Conserved Transcriptional Profiles during Mammalian Spermatogenesis	66
Early human embryonic development: Blastocyst formation to gastrulation	66
Durotaxis: The Hard Path from In Vitro to In Vivo	66

Extracellular vesicles: Critical players during cell migration	65
Mechanical Coupling Coordinates the Co-elongation of Axial and Paraxial Tissues in Avian Embryos	65
The bone microenvironment increases phenotypic plasticity of ER+ breast cancer cells	65
Modeling Human TBX5 Haploinsufficiency Predicts Regulatory Networks for Congenital Heart Disease	64
A BIN2-GLK1 Signaling Module Integrates Brassinosteroid and Light Signaling to Repress Chloroplast Development in the Dark	64
An Excitable Ras/PI3K/ERK Signaling Network Controls Migration and Oncogenic Transformation in Epithelial Cells	62
Mechanics of Development	62
Actin-Membrane Release Initiates Cell Protrusions	61
3D mesenchymal cell migration is driven by anterior cellular contraction that generates an extracellular matrix prestrain	61
Exaptive Evolution of Target of Rapamycin Signaling in Multicellular Eukaryotes	60
A Self-Organized PLT/Auxin/ARR-B Network Controls the Dynamics of Root Zonation Development in Arabidopsis thaliana	60
Global and Site-Specific Effect of Phosphorylation on Protein Turnover	59
A spatial vascular transcriptomic, proteomic, and phosphoproteomic atlas unveils an angiocrine Tie–Wnt signaling axis in the liver	59
High-resolution 3D spatiotemporal transcriptomic maps of developing Drosophila embryos and larvae	59
Inflammation of the Embryonic Choroid Plexus Barrier following Maternal Immune Activation	59
Programmable Extracellular Vesicles for Macromolecule Delivery and Genome Modifications	58
Excessive R-loops trigger an inflammatory cascade leading to increased HSPC production	58
Harnessing Mechanobiology for Tissue Engineering	58
Spatiotemporal mapping of gene expression landscapes and developmental trajectories during zebrafish embryogenesis	57
Aging-dependent regulatory cells emerge in subcutaneous fat to inhibit adipogenesis	57
Glutamine Metabolism Controls Chondrocyte Identity and Function	56
α-tubulin tail modifications regulate microtubule stability through selective effector recruitment, not changes in intrinsic polymer dynamics	55
A human breast atlas integrating single-cell proteomics and transcriptomics	54
The imprinted Igf2-Igf2r axis is critical for matching placental microvasculature expansion to fetal growth	53
Physical properties of the cytoplasm modulate the rates of microtubule polymerization and depolymerization	53
Phase Separation in Germ Cells and Development	53
Stromal SOX2 Upregulation Promotes Tumorigenesis through the Generation of a SFRP1/2-Expressing Cancer-Associated Fibroblast Population	52
Metabolic Communication and Healthy Aging: Where Should We Focus Our Energy?	52
Single-cell analysis of human testis aging and correlation with elevated body mass index	52
Diverse Routes toward Early Somites in the Mouse Embryo	52
N6-Adenosine Methylation of Socs1 mRNA Is Required to Sustain the Negative Feedback Control of Macrophage Activation	51
Microtubule-sliding modules based on kinesins EG5 and PRC1-dependent KIF4A drive human spindle elongation	51
Subcellular mRNA Localization Regulates Ribosome Biogenesis in Migrating Cells	51
Transnitrosylation Mediated by the Non-canonical Catalase ROG1 Regulates Nitric Oxide Signaling in Plants	50
Selective Lysosome Membrane Turnover Is Induced by Nutrient Starvation	50
Liquid-liquid phase separation of RBGD2/4 is required for heat stress resistance in Arabidopsis	50
CDK-Regulated Phase Separation Seeded by Histone Genes Ensures Precise Growth and Function of Histone Locus Bodies	50
Membrane receptor-mediated mechano-transduction maintains cell integrity during pollen tube growth within the pistil	49
ERK1/2 inhibition promotes robust myotube growth via CaMKII activation resulting in myoblast-to-myotube fusion	49
WASp triggers mechanosensitive actin patches to facilitate immune cell migration in dense tissues	49
Metabolic Cellular Communications: Feedback Mechanisms between Membrane Lipid Homeostasis and Plant Development	49
Hedgehog Pathway Activation Requires Coreceptor-Catalyzed, Lipid-Dependent Relay of the Sonic Hedgehog Ligand	49
Specialized endothelial tip cells guide neuroretina vascularization and blood-retina-barrier formation	49
VAP-A and its binding partner CERT drive biogenesis of RNA-containing extracellular vesicles at ER membrane contact sites	49
A Dedicated Evolutionarily Conserved Molecular Network Licenses Differentiated Cells to Return to the Cell Cycle	48
ICAM-1-mediated adhesion is a prerequisite for exosome-induced T cell suppression	48
Metabolic Regulation of Inflammasome Activity Controls Embryonic Hematopoietic Stem and Progenitor Cell Production	48
Lineage-Resolved Enhancer and Promoter Usage during a Time Course of Embryogenesis	47
Subcellular coordination of plant cell wall synthesis	47
The central moTOR of metabolism	47
Tether Me, Tether Me Not—Dynamic Organelle Contact Sites in Metabolic Rewiring	47
Global mapping of glycosylation pathways in human-derived cells	47
Embryonic Stem Cell-Derived Extracellular Vesicles Maintain ESC Stemness by Activating FAK	47
Modulation of the Promoter Activation Rate Dictates the Transcriptional Response to Graded BMP Signaling Levels in the Drosophila Embryo	47
Caveolae Control Contractile Tension for Epithelia to Eliminate Tumor Cells	47
The structure and spontaneous curvature of clathrin lattices at the plasma membrane	46
Hyperinsulinemia Drives Epithelial Tumorigenesis by Abrogating Cell Competition	46
Cholesterol transport between cellular membranes: A balancing act between interconnected lipid fluxes	46
A Weak Link with Actin Organizes Tight Junctions to Control Epithelial Permeability	45
DDX3X Suppresses the Susceptibility of Hindbrain Lineages to Medulloblastoma	45
Lipid-mediated motor-adaptor sequestration impairs axonal lysosome delivery leading to autophagic stress and dystrophy in Niemann-Pick type C	45
Exploring the Influence of Cell Metabolism on Cell Fate through Protein Post-translational Modifications	45
Frizzled-Dependent Planar Cell Polarity without Secreted Wnt Ligands	45
A ROS-dependent mechanism promotes CDK2 phosphorylation to drive progression through S phase	45
Mitochondrial dynamics regulate genome stability via control of caspase-dependent DNA damage	44
Reticulon-3 Promotes Endosome Maturation at ER Membrane Contact Sites	44
Determinants of Endoplasmic Reticulum-to-Lipid Droplet Protein Targeting	43
Genetically variant human pluripotent stem cells selectively eliminate wild-type counterparts through YAP-mediated cell competition	42
RBPMS is an RNA-binding protein that mediates cardiomyocyte binucleation and cardiovascular development	42
A unique macrophage subpopulation signals directly to progenitor cells to promote regenerative neurogenesis in the zebrafish spinal cord	42
Genetic variation associated with condensate dysregulation in disease	42
Formation of polarized contractile interfaces by self-organized Toll-8/Cirl GPCR asymmetry	42
LIMD1 phase separation contributes to cellular mechanics and durotaxis by regulating focal adhesion dynamics in response to force	42
Distinct Cation Gradients Power Cholesterol Transport at Different Key Points in the Hedgehog Signaling Pathway	41
Glucose starvation induces autophagy via ULK1-mediated activation of PIKfyve in an AMPK-dependent manner	41
Spatial transcriptional mapping of the human nephrogenic program	41
Compartmentalization of telomeres through DNA-scaffolded phase separation	41
The Perinuclear ER Scales Nuclear Size Independently of Cell Size in Early Embryos	40
Diversity of developing peripheral glia revealed by single-cell RNA sequencing	40
A switch in pdgfrb cell-derived ECM composition prevents inhibitory scarring and promotes axon regeneration in the zebrafish spinal cord	40

Localized EMT reprograms glial progenitors to promote spinal cord repair	40
Single-cell transcriptome analysis reveals three sequential phases of gene expression during zebrafish sensory hair cell regeneration	40
Dynamic chromatin state profiling reveals regulatory roles of auxin and cytokinin in shoot regeneration	40
Biomolecular Condensates and Gene Activation in Development and Disease	40
Essential Functions of Glycans in Human Epithelia Dissected by a CRISPR-Cas9-Engineered Human Organotypic Skin Model	39
Messenger RNA 5′ NAD+ Capping Is a Dynamic Regulatory Epitranscriptome Mark That Is Required for Proper Response to Abscisic Acid in Arabidopsis	39
The spatiotemporal dynamics of microglia across the human lifespan	39
Beyond PROX1: transcriptional, epigenetic, and noncoding RNA regulation of lymphatic identity and function	39
Scaling a Dpp Morphogen Gradient through Feedback Control of Receptors and Co-receptors	39
Cooperation between melanoma cell states promotes metastasis through heterotypic cluster formation	38
Reprogramming Axial Level Identity to Rescue Neural-Crest-Related Congenital Heart Defects	38
Endogenous Retrovirus-Derived lncRNA BANCR Promotes Cardiomyocyte Migration in Humans and Non-human Primates	38
ASK1-Mediated Phosphorylation Blocks HDAC6 Ubiquitination and Degradation to Drive the Disassembly of Photoreceptor Connecting Cilia	38
Homology-directed repair protects the replicating genome from metabolic assaults	38
Functional Diversification of SRSF Protein Kinase to Control Ubiquitin-Dependent Neurodevelopmental Signaling	38
Cell-specific cis-regulatory elements and mechanisms of non-coding genetic disease in human retina and retinal organoids	38
Xist Repeats A and B Account for Two Distinct Phases of X Inactivation Establishment	38
Rapid Homeostatic Turnover of Embryonic ECM during Tissue Morphogenesis	37
A multiscale analysis of early flower development in Arabidopsis provides an integrated view of molecular regulation and growth control	37
Enhancer decommissioning imposes an epigenetic barrier to sensory hair cell regeneration	37
A Specialized Niche in the Pancreatic Microenvironment Promotes Endocrine Differentiation	37
Oncogene-regulated release of extracellular vesicles	37
Cardiac proteomics reveals sex chromosome-dependent differences between males and females that arise prior to gonad formation	37
A reflux-and-growth mechanism explains oscillatory patterning of lateral root branching sites	36
Temporal analyses of postnatal liver development and maturation by single-cell transcriptomics	35
Combinatorial Action of Temporally Segregated Transcription Factors	35
Inositol Polyphosphate Multikinase Inhibits Liquid-Liquid Phase Separation of TFEB to Negatively Regulate Autophagy Activity	35
Cell size homeostasis is maintained by CDK4-dependent activation of p38 MAPK	35
iPSC-derived myelinoids to study myelin biology of humans	35
Diverse epigenetic mechanisms maintain parental imprints within the embryonic and extraembryonic lineages	35
Abscission Couples Cell Division to Embryonic Stem Cell Fate	35
HLH-30/TFEB Is a Master Regulator of Reproductive Quiescence	34
Autophagy promotes cell survival by maintaining NAD levels	34
A Ca2+-sensor switch for tolerance to elevated salt stress in Arabidopsis	34
Reprogrammed lipid metabolism protects inner nuclear membrane against unsaturated fat	34
Transient Nodal Signaling in Left Precursors Coordinates Opposed Asymmetries Shaping the Heart Loop	33
Neuronal mitochondrial dynamics coordinate systemic mitochondrial morphology and stress response to confer pathogen resistance in C. elegans	32
Phase Separation—A Physical Mechanism for Organizing Information and Biochemical Reactions	32
An essential role for the piRNA pathway in regulating the ribosomal RNA pool in C. elegans	32
Large-scale chromatin reorganization reactivates placenta-specific genes that drive cellular aging	32
Proteostasis failure and mitochondrial dysfunction leads to aneuploidy-induced senescence	32
Transit-Amplifying Cells Coordinate Changes in Intestinal Epithelial Cell-Type Composition	31
Endolysosomal Targeting of Mitochondria Is Integral to BAX-Mediated Mitochondrial Permeabilization during Apoptosis Signaling	31
A potassium-sensing niche in Arabidopsis roots orchestrates signaling and adaptation responses to maintain nutrient homeostasis	31
Mechanobiology of the Mitotic Spindle	31
Apoptotic cells represent a dynamic stem cell niche governing proliferation and tissue regeneration	31
PDGF signaling inhibits mitophagy in glioblastoma stem cells through N-methyladenosine	31
Paramecium Polycomb repressive complex 2 physically interacts with the small RNA-binding PIWI protein to repress transposable elements	31
FoxA-dependent demethylation of DNA initiates epigenetic memory of cellular identity	31
Filopodium-derived vesicles produced by MIM enhance the migration of recipient cells	31
Metabolic plasticity drives development during mammalian embryogenesis	30
Heart regeneration: 20 years of progress and renewed optimism	30
Plant glutamate receptors mediate a bet-hedging strategy between regeneration and defense	30
Cell cycle regulation of ER membrane biogenesis protects against chromosome missegregation	30
Gene regulatory networks shape developmental plasticity of root cell types under water extremes in rice	30
Adaptations in Hippo-Yap signaling and myofibroblast fate underlie scar-free ear appendage wound healing in spiny mice	30
Tumor-induced disruption of the blood-brain barrier promotes host death	30
Mechanical feedback defines organizing centers to drive digit emergence	29
Coordinate regulation of the senescent state by selective autophagy	29
Progenitor-like characteristics in a subgroup of UCP1+ cells within white adipose tissue	29
Human placental cytotrophoblast epigenome dynamics over gestation and alterations in placental disease	29
Opposing motors provide mechanical and functional robustness in the human spindle	29
The myogenesis program drives clonal selection and drug resistance in rhabdomyosarcoma	29
Maintaining the structural and functional homeostasis of the plant endoplasmic reticulum	29
Cell Junction Mechanics beyond the Bounds of Adhesion and Tension	29
Oxidative stress pathogenically remodels the cardiac myocyte cytoskeleton via structural alterations to the microtubule lattice	29
Developmental landscape of human forebrain at a single-cell level identifies early waves of oligodendrogenesis	29
De novo endocytic clathrin coats develop curvature at early stages of their formation	28
Rewired glycosylation activity promotes scarless regeneration and functional recovery in spiny mice after complete spinal cord transection	28
Cytoplasm’s Got Moves	28
Identification of long-lived proteins in the mitochondria reveals increased stability of the electron transport chain	28
PRL3-DDX21 Transcriptional Control of Endolysosomal Genes Restricts Melanocyte Stem Cell Differentiation	28
Mechanistic connections between mitochondrial biology and regulated cell death	28
Motor usage imprints microtubule stability along the shaft	28
External Mechanical Cues Reveal a Katanin-Independent Mechanism behind Auxin-Mediated Tissue Bending in Plants	28
The Lipid Droplet Knowledge Portal: A resource for systematic analyses of lipid droplet biology	28
DNA Helicase Mph1FANCM Ensures Meiotic Recombination between Parental Chromosomes by Dissociating Precocious Displacement Loops	28
Tyramine Acts Downstream of Neuronal XBP-1s to Coordinate Inter-tissue UPRER Activation and Behavior in C. elegans	28
Transgenerational inheritance of sexual attractiveness via small RNAs enhances evolvability in C. elegans	27
The Mitotic Crosslinking Protein PRC1 Acts Like a Mechanical Dashpot to Resist Microtubule Sliding	27
Mechanical competition triggered by innate immune signaling drives the collective extrusion of bacterially infected epithelial cells	27
Long-Range Optogenetic Control of Axon Guidance Overcomes Developmental Boundaries and Defects	27
Small Extracellular Vesicle Regulation of Mitochondrial Dynamics Reprograms a Hypoxic Tumor Microenvironment	27
3D biomimetic platform reveals the first interactions of the embryo and the maternal blood vessels	27
Less Is More: Rare Pulmonary Neuroendocrine Cells Function as Critical Sensors in Lung	27
piRNAs initiate transcriptional silencing of spermatogenic genes during C. elegans germline development	27
Airway basal stem cells reutilize the embryonic proliferation regulator, Tgfβ-Id2 axis, for tissue regeneration	27
Lipid metabolism in adaptation to extreme nutritional challenges	27
Ankmy2 Prevents Smoothened-Independent Hyperactivation of the Hedgehog Pathway via Cilia-Regulated Adenylyl Cyclase Signaling	27
A subpopulation of embryonic microglia respond to maternal stress and influence nearby neural progenitors	27
PI5P4Ks drive metabolic homeostasis through peroxisome-mitochondria interplay	27
Ubiquitin-dependent remodeling of the actin cytoskeleton drives cell fusion	26
CREB Non-autonomously Controls Reproductive Aging through Hedgehog/Patched Signaling	26
A two-tier junctional mechanism drives simultaneous tissue folding and extension	26
The Oncogenic PRL Protein Causes Acid Addiction of Cells by Stimulating Lysosomal Exocytosis	26