Experimental Biology and Medicine

Article	Citations
The β-catenin/CBP signaling axis participates in sepsis-induced inflammatory lung injury	89
EXPRESSION OF CONCERN: Diabetic human adipose tissue-derived mesenchymal stem cells fail to differentiate in functional adipocytes	60
Overexpression of HOXA10 promotes the growth and metastasis of nasopharyngeal carcinoma	52
Identification of key genes involved in calcific aortic valve disease based on integrated bioinformatics analysis	51
Stattic alleviates pulmonary fibrosis in a mouse model of rheumatoid arthritis–relevant interstitial lung disease	46
Pyrotinib combining with radiotherapy on breast cancer with brain metastasis	42
Bee venom ameliorates cardiac dysfunction in diabetic hyperlipidemic rats	40
Safety and feasibility of the gene transfer of hemopexin for conditions with increased free heme	34
Identifying immune subtypes of uterine corpus endometrial carcinoma and a four-paired-lncRNA signature with immune-related lncRNAs	32
Dual detection of COVID-19 antigens and antibodies using nanoscale fluorescent plasmonic substrates	32
Protective effects of molecular hydrogen on lung injury from lung transplantation	29
Regenerative and stem cell-based techniques for facial rejuvenation	29
Effects of autoimmune abnormalities on skeletal muscle regeneration after needle puncture in mice	28
E2F3 drives the epithelial-to-mesenchymal transition, cell invasion, and metastasis in breast cancer	27
Osteopontin as a biomarker for COVID-19 severity and multisystem inflammatory syndrome in children: A pilot study	27
Is COVID-19-associated cytokine storm distinct from non-COVID-19 secondary hemophagocytic lymphohistiocytosis?	26
Bioelectric, tissue, and molecular characteristics of the gastric mucosa at different times of ischemia	25
In vivo visualization and analysis of ciliary motion in allergic rhinitis models induced by ovalbumin	23
Sphingosine kinase 2 regulates insulin receptor trafficking in hepatocytes	23
Calcitriol ameliorates damage in high-salt diet-induced hypertension: Evidence of communication with the gut–kidney axis	23
Roles of IL-33 in the Pathogenesis of Cardiac Disorders	22
Introduction to the Regenerative Medicine Thematic Issue	22
GPER1 contributes to T3-induced osteogenesis by mediating glycolysis in osteoblast precursors	21
Circulating H-FABP as a biomarker of frailty in patients with chronic heart failure	21
Risk factors for neonatal VAP: A retrospective cohort study	21

Participation of ASK-1 in the cardiomyocyte-protective role of mechanical ventilation in a rat model of myocardial infarction	20
Structural analysis of SARS-Cov-2 nonstructural protein 1 polymorphisms found in the Brazilian Amazon	20
Proteomics analysis of carotid body tumor revealed potential mechanisms and molecular differences among Shamblin classifications	20
Engineering microenvironments for manufacturing therapeutic cells	20
Transcriptomic profiling of cerebrospinal fluid identifies ALS pathway enrichment and RNA biomarkers in MND individuals	20
Research of restricted migration evaluation of MDA-MB-231 cells in 2D and 3D co-culture models	19
Mechanisms of cell injury induced by inhaled molybdenum trioxide nanoparticles in Golden Syrian Hamsters	19
Identification of key biomarkers for thyroid cancer by integrative gene expression profiles	19
Endogenous drivers of altered immune cell metabolism	18
Single-nucleotide polymorphisms of TLR4 and GAS7 linked to primary open-angle glaucoma among patients of Shenyang, China	18
Impacts of microgravity on amino acid metabolism during spaceflight	18
A quantum-based oversampling method for classification of highly imbalanced and overlapped data	18
Quantitative multiplexed strategies for human Lyme disease serological testing	17
Mouse embryonic stem cells require multiple amino acids	17
Particulate matter exposure predicts residence in high-risk areas for community acquired pneumonia among hospitalized children	17
Therapeutic strategies to improve liver regeneration after hepatectomy	17
A review on photo-mediated ultrasound therapy	17
Development of a novel purification protocol to isolate and identify brain microglia	16
Resistin stimulates PC-3 prostate cancer cell growth through stimulation of SOCS3 and SOCS5 genes	16
Three-dimensional segmentation and depth-encoded visualization of choroidal vasculature using swept-source optical coherence tomography	16
Effects of moderate-continuous and high-intensity interval aerobic training on cardiac function of spontaneously hypertensive rats	16
Revisiting the role of lysophosphatidic acid in stem cell biology	16
In vitro contractile studies within isolated tissue baths: Translational research from Visible Heart® Laboratories	16
The role of mediator complex subunit 19 in human diseases	16
Deep learning prediction of attention-deficit hyperactivity disorder in African Americans by copy number variation	15
Identification in synovial fluid of a new potential pathogenic player in arthropathies	15
Heterogeneity of humoral response patterns in mildly symptomatic, non-hospitalized COVID-19 patients: A one-year longitudinal study	15
Comprehensive analysis of INHBA: A biomarker for anti-TGFβ treatment in head and neck cancer	15
Therapeutic potentials of stem cell–derived exosomes in cardiovascular diseases	15
Niacin promotes the efflux of lysosomal cholesterol from macrophages via the CD38/NAADP signaling pathway	15
Combining contrast-enhanced ultrasound and blood cell analysis to improve diagnostic accuracy of plasma cell mastitis	15
SARS-CoV-2 variants: A double-edged sword?	15
Apelin-13 prevents the effects of oxygen–glucose deprivation/reperfusion on bEnd.3 cells by inhibiting AKT–mTOR signaling	15
Machine learning and deep learning for brain tumor MRI image segmentation	14
Hyperinflammation, apoptosis, and organ damage	14
Mutant U2AF1-induced differential alternative splicing causes an oxidative stress in bone marrow stromal cells	14
Assessment of the influence on left ventricle by potassium oxonate and hypoxanthine–induced chronic hyperuricemia	14
MiR-296-5p ameliorates deep venous thrombosis by inactivating S100A4	14
The intestinal microbiota as mediators between dietary contaminants and host health	14
Evolving techniques for reducing phantom limb pain	14
Corrigendum	14
Regulation of Th1/Th2 and Th17/Treg by pDC/mDC imbalance in primary immune thrombocytopenia	14
Preclinical and clinical studies of bintrafusp alfa, a novel bifunctional anti-PD-L1/TGFβRII agent: Current status	14
Apigeninidin-enriched Sorghum bicolor (L. Moench) extracts alleviate Aflatoxin B1-induced dysregulation of male rat hypothalamic-reproductive axis	14
Decision rules for personalized statin treatment prescriptions over multi-objectives	14
Clinical and genetic investigations in Chinese families with retinitis pigmentosa	14
EXPRESSION OF CONCERN: Chondroitin-4-Sulphate Reduced Oxidative Injury in Caerulein-Induced Pancreatitis in Mice: The Involvement of NF-κB Translocation and Apoptosis Activation	14
Protective effect of aldehyde dehydrogenase 2 against rat corneal dysfunction caused by streptozotocin-induced type I diabetes	14
Cell cycle disturbances in mucopolysaccharidoses: Transcriptomic and experimental studies on cellular models	14
Identification of SARS-CoV-2 on the ocular surface in a cohort of COVID-19 patients from Brazil	13

Enriched environment as a nonpharmacological neuroprotective strategy	13
The third dimension of tumor microenvironment—The importance of tumor stroma in 3D cancer models	13
Changes in gene expression and neuroinflammation in the hippocampus of rats with poststroke cognitive impairment	13
Green synthesized silver nanoparticles for the treatment of diabetes and the related complications of hyperlipidemia and oxidative stress in diabetic rats	13
Matrix metalloproteinases are key targets of acupuncture in the treatment of ulcerative colitis	13
Bioinformatics analysis of the genes associated with co-occurrence of heart failure and lung cancer	13
Diagnostic and prognostic nomograms for newly diagnosed intrahepatic cholangiocarcinoma with brain metastasis: A population-based analysis	12
Influence of polymorphic variations of IFNL, HLA, and IL-6 genes in severe cases of COVID-19	12
The role of calcium-sensing receptor signaling in regulating transepithelial calcium transport	12
Wogonin, as a potent anticancer compound: From chemistry to cellular interactions	12
Single-cell RNA sequencing reveals differential expression of EGFL7 and VEGF in giant-cell tumor of bone and osteosarcoma	12
TFPI and FXIII negatively and S100A8/A9 and Cystatin C positively correlate with D-dimer in COVID-19	11
Paraoxonase 1 rs662 polymorphism, its related variables, and COVID-19 intensity: Considering gender and post-COVID complications	11
Contusion concomitant with ischemia injury aggravates skeletal muscle necrosis and hinders muscle functional recovery	11
Store-operated Ca2+ channel signaling: Novel mechanism for podocyte injury in kidney disease	11
Creative and generative artificial intelligence for personalized medicine and healthcare: Hype, reality, or hyperreality?	11
Eugenol alleviates neuronal damage via inhibiting inflammatory process against pilocarpine-induced status epilepticus	11
Identifying a cervical cancer survival signature based on mRNA expression and genome-wide copy number variations	11
Normative intercapillary distance and vessel density data in the temporal retina assessed by wide-field spectral-domain optical coherence tomography angiography	11
Rett and Rett-related disorders: Common mechanisms for shared symptoms?	11
Circulating exosomal microRNA-4497 as a potential biomarker for metastasis and prognosis in non-small-cell lung cancer	11
Melatonin pretreatment modulates anti-inflammatory, antioxidant, YKL-40, and matrix metalloproteinases in endotoxemic rat lung tissue	10
Barley microgreen incorporation in diet-controlled diabetes and counteracted aflatoxicosis in rats	10
Gentiopicroside alleviates acute myocardial infarction injury in rats by disrupting Nrf2/NLRP3 signaling	10
Association between serum placental growth factor and vascular endothelial function in hyprtensive disorders complicating pregnancy	10
Nucleated red blood cells participate in myocardial regeneration in the toad Bufo Gargarizan Gargarizan	10
Strategies for intra-amniotic administration of fetal therapy in a rabbit model of intrauterine growth restriction	10
Penicillin-binding protein (PBP) inhibitor development: A 10-year chemical perspective	10
Silencing of FAM111B inhibits tumor growth and promotes apoptosis by decreasing AKT activity in ovarian cancer	10
The continuing evolution of barcode applications: Functional toxicology to cell lineage	10
ONECUT2 which is targeted by hsa-miR-15a-5p enhances stemness maintenance of gastric cancer stem cells	10
Therapeutically leveraging GABAA receptors in cancer	10
Metformin and retinal diseases in preclinical and clinical studies: Insights and review of literature	10
S-allylmercapto-N-acetylcysteine protects bone cells from oxidation and improves femur microarchitecture in healthy and diabetic mice	10
New and effective method to develop primary hepatocytes from liver cancer patients	10
Serum homocysteine is a valuable marker for predicting aggravation of infection in intestinal obstruction patients	9
Combining tissue clearing and Fluoro-Jade C labeling for neurotoxicity assessments	9
Data science in drug discovery safety: Challenges and opportunities	9
Focused ultrasound stimulation on meibomian glands for the treatment of evaporative dry eye	9
Autotaxin–lysophosphatidic acid receptor 5 axis evokes endothelial dysfunction via reactive oxygen species signaling	9
Mesenchymal stem cells with p38 mitogen-activated protein kinase interference ameliorate mouse ischemic stroke	9
Antibiotic impregnation and nanocoating of external ventricular drainage catheters for antibacterial applications: Evaluation of in vitro studies and molecular docking	9
HnRNP K regulates inflammatory gene expression by mediating splicing pattern of transcriptional factors	9
Toll-like receptor 3 signaling induces interferon-induced transmembrane protein 1 in BEAS-2B cells	9
TGFβ1 induces CXCL1 to promote stemness features in lung cancer	9
The influence of multidisciplinary team clinic on the prognosis of patients with chronic kidney disease	9
The infrapatellar fat pad contributes to spontaneous healing after complete anterior cruciate ligament injury	9
Differential expression profile of plasma exosomal microRNAs in chronic rhinosinusitis with nasal polyps	8
The expression and function of growth hormone secretagogue receptor in immune cells: A current perspective	8
Association of genetic variants rs641153 (CFB), rs2230199 (C3), and rs1410996 (CFH) with age-related macular degeneration in a Brazilian population	8
High-quality RNA improves sensitivity of SARS-CoV-2 detection by colorimetric RT-LAMP	8
Cassava microfiber–reinforced gelatin scaffold holds promise for tissue engineering by exhibiting cytocompatibility with HEK 293 cells	8
Role of long interspersed nuclear element-1 in the regulation of chromatin landscapes and genome dynamics	8
A primordial target: Mitochondria mediate both primary and collateral anesthetic effects of volatile anesthetics	8
Molecular and environmental contributors to neurological complications in sickle cell disease	8
Circulating LIPCAR is a potential biomarker of heart failure in patients post-acute myocardial infarction	8
Neutrophil extracellular traps contributing to atherosclerosis: From pathophysiology to clinical implications	8
Systematic analysis of molecular characterization and clinical relevance of m6A regulators in digestive system pan-cancers	8
Vagal milieu or electrophysiologic substrate? The link between atrial fibrillation and obstructive sleep apnea	8
Neonatal coagulopathies: A review of established and emerging treatments	8
Stopping the COVID-19 pandemic in dental offices: A review of SARS-CoV-2 transmission and cross-infection prevention	8
N-acetylcysteine improves autism-like behavior by recovering autophagic deficiency and decreasing Notch-1/Hes-1 pathway activity	8
The “ideal protein” concept is not ideal in animal nutrition	8
Dietary supplementation with L-leucine reduces nitric oxide synthesis by endothelial cells of rats	8
Transcriptomic profile of the mechanosensitive ion channelome in human cardiac fibroblasts	8
Manipulation of genes could inhibit SARS-CoV-2 infection that causes COVID-19 pandemics	8
Epigallocatechin-3-gallate attenuates myocardial fibrosis in diabetic rats by activating autophagy	7
Implications of fibrotic extracellular matrix in diabetic retinopathy	7
Irisin induces white adipose tissue browning in mice as assessed by magnetic resonance imaging	7
Identification of a circRNA-mediated comprehensive ceRNA network in spinal cord injury pathogenesis	7
Aldh1a1andScl25a30in diaphragmatic dysfunction	7
Increasing adverse drug events extraction robustness on social media: Case study on negation and speculation	7
Image reconstruction for endoscopic photoacoustic tomography including effects of detector responses	7
Transmembrane serine protease 2 cleaves nidogen 1 and inhibits extrahepatic liver cancer cell migration and invasion	7
Classification of salivary bacteriome in asymptomatic COVID-19 cases based on long-read nanopore sequencing	7
Olaparib attenuates sepsis-induced acute multiple organ injury via ERK-mediated CD14 expression	7
Identification of molecular subtyping system and four-gene prognostic signature with immune-related genes for uveal melanoma	7
PGM3 regulates beta-catenin activity to promote colorectal cancer cell progression	7
Sex differences in muscle SIRT1 and SIRT3 and exercise + weight loss effects on muscle sirtuins	7
Cellular senescence and the blood–brain barrier: Implications for aging and age-related diseases	7

Indoxyl sulfate impairs in vitro erythropoiesis by triggering apoptosis and senescence	7
Abdominal paracentesis drainage attenuates intestinal mucosal barrier damage through macrophage polarization in severe acute pancreatitis	7
BPA interferes with granulosa cell development and oocyte meiosis in mouse preantral follicles	7
URNet: System for recommending referrals for community screening of diabetic retinopathy based on deep learning	7
MicroRNA 205-5p and COVID-19 adverse outcomes: Potential molecular biomarker and regulator of the immune response	7
Regulation of lymphangiogenesis by extracellular vesicles in cancer metastasis	7
Formyl peptide receptor 1 promotes podocyte injury through regulation of mitogen-activated protein kinase pathways	7
c-Src inhibitor PP2 inhibits head and neck cancer progression through regulation of the epithelial–mesenchymal transition	7
Physical activity and exercise as an essential medical strategy for the COVID-19 pandemic and beyond	7
Corrigendum	7
Shear type and magnitude affect aortic valve endothelial cell morphology, orientation, and differentiation	7
Cancer and stem cells	7
Phenethyl isothiocyanate protects against cyclophosphamide-induced nephrotoxicity via nuclear factor E2–related factor 2 pathway in rats	7
Quantification of biomechanical properties of human corneal scar using acoustic radiation force optical coherence elastography	7
Enhancing the sensitivity of ovarian cancer cells to olaparib via microRNA-20b-mediated cyclin D1 targeting	7
Epigallocatechin-3-gallate ameliorates renal endoplasmic reticulum stress-mediated inflammation in type 2 diabetic rats	7
In vitro comparative evaluation of Tamarix gallica extracts for antioxidant and antidiabetic activity	7
Comprehensive analysis of dysregulated genes associated with atherosclerotic plaque destabilization	7
Mild hypobaric hypoxia influences splenic proliferation during the later phase of stress erythropoiesis	7
TRIM28 suppresses cancer stem-like characteristics in gastric cancer cells through Wnt/β-catenin signaling pathways	7
Improved protocol for Bst polymerase and reverse transcriptase production and application to a point-of-care diagnostics system	7
Leonurine pretreatment protects the heart from myocardial ischemia-reperfusion injury	6
Complement factor H deficiency combined with smoking promotes retinal degeneration in a novel mouse model	6
Relationship between hyperglycemia, waist circumference, and the course of COVID-19: Mortality risk assessment	6
Retraction Notice	6
Oral microbiota in human health and disease: A perspective	6
The alleles of AGT and HIF1A gene affect the risk of hypertension in plateau residents	6
Longitudinal dysregulation of long non-coding RNAs in Parkinson’s disease	6
In-ovo imaging using ostrich eggs: Biomagnetism for detection of cardiac signals and embryonal motion	6
Interleukin-10 regulates starvation-induced autophagy through the STAT3-mTOR-p70s6k axis in hepatic stellate cells	6
The value of serum TRAP1 in diagnosing small cell lung cancer and tumor immunity	6
Effect of the ratio of vessel-specific volume to fractional myocardial mass on fractional flow reserve	6
Expressing MLH1 in HCT116 cells increases cellular resistance to radiation by activating the PRKAC	6
Evaluation of the mechanisms of heme-induced tissue factor activation: Contribution of innate immune pathways	6
Synthesis of glycine from 4-hydroxyproline in tissues of neonatal pigs with intrauterine growth restriction	6
A new insight of immunosuppressive microenvironment in osteosarcoma lung metastasis	6
Phenotyping in clinical text with unsupervised numerical reasoning for patient stratification	6
Pancreatic acinar cells utilize tyrosine to synthesize L-dihydroxyphenylalanine	6
Innovative approaches for treatment of osteosarcoma	6
Zebrafish patient-derived xenografts accurately and quickly reproduce treatment outcomes in non–small cell lung cancer patients	6
Identification and validation of hub genes in CD5-positive diffuse large B-cell lymphoma	6
LncRNA XLOC_015548 affects the proliferation and differentiation of myoblasts via the MAPK signaling pathway	6
Tripartite motif-containing 25 facilitates immunosuppression and inhibits apoptosis of glioma via activating NF-κB	6
Retraction Notice	6
CCK2-receptor deficiency impairs immune balance by influencing CD4+ T cells development by inhibiting cortical-thymic-epithelial-cells	6
Cell death signaling in Anopheles gambiae initiated by Bacillus thuringiensis Cry4B toxin involves Na+/K+ ATPase	6
Classifying and evaluating fetuses with multicystic dysplastic kidney in etiologic studies	6
Recombinant antigen delivery to dendritic cells as a way to improve vaccine design	6
Metabolomic profiling of anaerobic and aerobic energy metabolic pathways in chronic obstructive pulmonary disease	6
Macrophage polarization in hypoxia and ischemia/reperfusion: Insights into the role of energetic metabolism	6
GP5 regulates epithelial–mesenchymal transition in breast cancer via the PI3K/AKT signaling pathway	5
Gene expression profile suggests different mechanisms underlying sporadic and familial mesial temporal lobe epilepsy	5
Thermo- and pH-sensitive nanoparticles of poly (N-isopropylacrylamide-decenoic acid-1-vinylimidazole) for ultrasound switchable fluorescence imaging	5
Integrating artificial intelligence with bioinformatics promotes public health	5
Effects of a high-salt diet on MAP and expression levels of renal ENaCs and aquaporins in SHR	5
2-Bromopalmitate inhibits malignant behaviors of HPSCC cells by hindering the membrane location of Ras protein	5
Recent advances in nanotechnology-enabled biosensors for detection of exosomes as new cancer liquid biopsy	5
D4F alleviates the C/EBP homologous protein-mediated apoptosis in glycated high-density lipoprotein-treated macrophages by facilitating autophagy	5
Potential therapeutic effects of Ivermectin in COVID-19	5
Establishment of a mouse model for ovarian cancer–associated venous thromboembolism	5
The inflammatory profiles of pulmonary alveolar macrophages and alveolar type 2 cells in SCD	5
The discovery of subunit-selective GluN1/GluN2B NMDAR antagonist via pharmacophere-based virtual screening	5
Exogenous surfactant reduces inflammation and redox imbalance in rats under prone or supine mechanical ventilation	5
Assessments of tumor mutational burden estimation by targeted panel sequencing: A comprehensive simulation analysis	5
Protective effects of glutamine on lipopolysaccharide/D-galactosamine-induced fulminant hepatitis in mice	5
Comparison of circulating bacterial profiles between mild and severe COVID-19 patients	5
Progress in the contrary effects of glucagon-like peptide-1 and chemerin on obesity development	5
Zoledronic acid modulates osteoclast apoptosis through activation of the NF-κB signaling pathway in ovariectomized rats	5
Inhibitory effect of hydnocarpin D on T-cell acute lymphoblastic leukemia via induction of autophagy-dependent ferroptosis	5
Surface fibrils on the particles of nucleocytoviruses: A review	5
Inferences of carboplatin response-related signature by integrating multiomics data in ovarian serous cystadenocarcinoma	5
What does desmin do: A bibliometric assessment of the functions of the muscle intermediate filament	5
Improved osteogenesis in rat femur segmental defects treated with human allograft and zinc adjuvants	5
Ubiquinol-cytochrome c reductase core protein 1 contributes to cardiac tolerance to acute exhaustive exercise	5
TBX1 regulates myogenic differentiation by activating the TGFβ-Smad2/3 pathway in myoblasts	5
Iron-based phosphorus chelator: Risk of iron deposition and action on bone metabolism in uremic rats	5
Structural and molecular biology of Sabiá virus	5
Association of heme-oxygenase 1, hemopexin, and heme levels with markers of disease severity in COVID-19	5
A comprehensive overview of PPM1A: From structure to disease	5
Triterpenoid CDDO-IM protects against lipopolysaccharide-induced inflammatory response and cytotoxicity in macrophages: The involvement of the NF-κB signaling pathway	5
Sex differences in prenatal programming of hypertension by dexamethasone	5
Statistical considerations for outcomes in clinical research: A review of common data types and methodology	5
Na+/K+-ATPase DR region antibody ameliorated cardiac hypertrophy and fibrosis in rats with 5/6 nephrectomy	5
Targeting endothelial coagulation signaling ameliorates liver obstructive cholestasis and dysfunctional angiogenesis	5
Data-driven approach to quantify trust in medical devices using Bayesian networks	5
Cone photoreceptor reflectance variation in the northern tree shrew and thirteen-lined ground squirrel	5
Role of follistatin-like protein 1 in liver diseases	4
The role of IL-33/ST2 signaling in the tumor microenvironment and Treg immunotherapy	4
Ethical and regulatory oversight of clinical research: The role of the Institutional Review Board	4
The molecular mechanisms of acetaminophen-induced hepatotoxicity and its potential therapeutic targets	4
hsa-miR-607, lncRNA TUG1 and hsa_circ_0071106 can be combined as biomarkers in type 2 diabetes mellitus	4
Role of sex hormones in lung cancer	4
Expression profiles of sporulation genes in multidrug-resistant Bacillus species isolated from intensive care units of Ghanaian hospital	4
Acute joint swelling in psoriatic arthritis: Flare or “psout”—A 10-year-monocentric study on synovial fluid	4
Recent insights into atherosclerotic plaque cell autophagy	4