Cancer Cell

Papers
(The median citation count of Cancer Cell is 10. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2020-05-01 to 2024-05-01.)
ArticleCitations
Oxidative Stress in Cancer1244
Conserved pan-cancer microenvironment subtypes predict response to immunotherapy521
The Challenges of Tumor Mutational Burden as an Immunotherapy Biomarker497
Patterns of transcription factor programs and immune pathway activation define four major subtypes of SCLC with distinct therapeutic vulnerabilities427
Targeting FTO Suppresses Cancer Stem Cell Maintenance and Immune Evasion389
The evolving tumor microenvironment: From cancer initiation to metastatic outgrowth385
Engineering CAR-T Cells for Next-Generation Cancer Therapy351
Proteogenomic and metabolomic characterization of human glioblastoma323
The PD-1/PD-L1-Checkpoint Restrains T cell Immunity in Tumor-Draining Lymph Nodes312
Single-cell analyses reveal key immune cell subsets associated with response to PD-L1 blockade in triple-negative breast cancer288
Lactic acid promotes PD-1 expression in regulatory T cells in highly glycolytic tumor microenvironments284
Clinical Challenges of Immune Checkpoint Inhibitors283
CD8+ T cells and fatty acids orchestrate tumor ferroptosis and immunity via ACSL4280
Challenges and Opportunities for Pancreatic Cancer Immunotherapy275
Type I collagen deletion in αSMA+ myofibroblasts augments immune suppression and accelerates progression of pancreatic cancer274
Tumor and immune reprogramming during immunotherapy in advanced renal cell carcinoma272
Molecular Subsets in Renal Cancer Determine Outcome to Checkpoint and Angiogenesis Blockade269
Seroconversion rates following COVID-19 vaccination among patients with cancer269
MYC Drives Temporal Evolution of Small Cell Lung Cancer Subtypes by Reprogramming Neuroendocrine Fate264
Cathepsin C promotes breast cancer lung metastasis by modulating neutrophil infiltration and neutrophil extracellular trap formation260
Interactions between cancer cells and immune cells drive transitions to mesenchymal-like states in glioblastoma255
Progressive immune dysfunction with advancing disease stage in renal cell carcinoma237
Nivolumab Plus Ipilimumab for Metastatic Castration-Resistant Prostate Cancer: Preliminary Analysis of Patients in the CheckMate 650 Trial221
Predicting Drug Response and Synergy Using a Deep Learning Model of Human Cancer Cells219
Microbiome and cancer218
Antibody response to SARS-CoV-2 vaccines in patients with hematologic malignancies216
Emergence of a High-Plasticity Cell State during Lung Cancer Evolution211
Targeting cell-cycle machinery in cancer210
YTHDF3 Induces the Translation of m6A-Enriched Gene Transcripts to Promote Breast Cancer Brain Metastasis198
Conserved Interferon-γ Signaling Drives Clinical Response to Immune Checkpoint Blockade Therapy in Melanoma194
Identifying and Targeting Human Tumor Antigens for T Cell-Based Immunotherapy of Solid Tumors194
Proteogenomic insights into the biology and treatment of HPV-negative head and neck squamous cell carcinoma190
COVID-19 and Cancer: Current Challenges and Perspectives188
Immunogenicity of SARS-CoV-2 messenger RNA vaccines in patients with cancer186
Toripalimab plus chemotherapy in treatment-naïve, advanced esophageal squamous cell carcinoma (JUPITER-06): A multi-center phase 3 trial185
Reduction of Liver Metastasis Stiffness Improves Response to Bevacizumab in Metastatic Colorectal Cancer185
SARS-CoV-2 Viral Load Predicts Mortality in Patients with and without Cancer Who Are Hospitalized with COVID-19185
Gut vascular barrier impairment leads to intestinal bacteria dissemination and colorectal cancer metastasis to liver183
Immunometabolic Interplay in the Tumor Microenvironment181
Single-cell sequencing links multiregional immune landscapes and tissue-resident T cells in ccRCC to tumor topology and therapy efficacy181
Spatially resolved multi-omics deciphers bidirectional tumor-host interdependence in glioblastoma177
Mesothelial cell-derived antigen-presenting cancer-associated fibroblasts induce expansion of regulatory T cells in pancreatic cancer174
Highly variable SARS-CoV-2 spike antibody responses to two doses of COVID-19 RNA vaccination in patients with multiple myeloma170
Single-cell lineage tracing of metastatic cancer reveals selection of hybrid EMT states170
Immunogenic Chemotherapy Enhances Recruitment of CAR-T Cells to Lung Tumors and Improves Antitumor Efficacy when Combined with Checkpoint Blockade168
Single-cell analysis defines a pancreatic fibroblast lineage that supports anti-tumor immunity166
Single-cell dissection of cellular components and interactions shaping the tumor immune phenotypes in ovarian cancer164
Single-cell analysis of human non-small cell lung cancer lesions refines tumor classification and patient stratification163
Signatures of plasticity, metastasis, and immunosuppression in an atlas of human small cell lung cancer163
Mutant p53 suppresses innate immune signaling to promote tumorigenesis160
Biomolecular Condensates and Cancer158
Promotion of cholangiocarcinoma growth by diverse cancer-associated fibroblast subpopulations157
Intratumoral plasma cells predict outcomes to PD-L1 blockade in non-small cell lung cancer156
Effect of ibrutinib with R-CHOP chemotherapy in genetic subtypes of DLBCL155
Comprehensive Analysis of Genetic Ancestry and Its Molecular Correlates in Cancer154
DNA Sensing in Mismatch Repair-Deficient Tumor Cells Is Essential for Anti-tumor Immunity154
The Glioma Stem Cell Model in the Era of Single-Cell Genomics151
Single-Cell Multiomics Sequencing Reveals Prevalent Genomic Alterations in Tumor Stromal Cells of Human Colorectal Cancer145
Single-Cell Characterization of Malignant Phenotypes and Developmental Trajectories of Adrenal Neuroblastoma143
An Embryonic Diapause-like Adaptation with Suppressed Myc Activity Enables Tumor Treatment Persistence143
Artificial intelligence for clinical oncology142
IL6/STAT3 Signaling Hijacks Estrogen Receptor α Enhancers to Drive Breast Cancer Metastasis142
Epigenomic State Transitions Characterize Tumor Progression in Mouse Lung Adenocarcinoma141
Immunomodulation by targeted anticancer agents139
Immune phenotypic linkage between colorectal cancer and liver metastasis137
Integrated Omics of Metastatic Colorectal Cancer136
Tumor Microenvironment-Derived NRG1 Promotes Antiandrogen Resistance in Prostate Cancer135
Durvalumab with olaparib and paclitaxel for high-risk HER2-negative stage II/III breast cancer: Results from the adaptively randomized I-SPY2 trial135
Visualizing Synaptic Transfer of Tumor Antigens among Dendritic Cells134
Inflammatory fibroblasts mediate resistance to neoadjuvant therapy in rectal cancer130
Arsenic Trioxide Rescues Structural p53 Mutations through a Cryptic Allosteric Site129
Tumor organoids: Opportunities and challenges to guide precision medicine128
Artificial intelligence for multimodal data integration in oncology128
Antibody and T cell immune responses following mRNA COVID-19 vaccination in patients with cancer126
Proteogenomic characterization identifies clinically relevant subgroups of intrahepatic cholangiocarcinoma125
Determinants of anti-PD-1 response and resistance in clear cell renal cell carcinoma124
Interleukin-6 blockade abrogates immunotherapy toxicity and promotes tumor immunity124
Activating a collaborative innate-adaptive immune response to control metastasis124
Commensal bacteria and fungi differentially regulate tumor responses to radiation therapy124
The loss of RNA N6-adenosine methyltransferase Mettl14 in tumor-associated macrophages promotes CD8+ T cell dysfunction and tumor growth123
The CD155/TIGIT axis promotes and maintains immune evasion in neoantigen-expressing pancreatic cancer123
Pan-cancer integrative histology-genomic analysis via multimodal deep learning121
Fungal mycobiome drives IL-33 secretion and type 2 immunity in pancreatic cancer120
Spatiotemporal co-dependency between macrophages and exhausted CD8+ T cells in cancer118
Oncogenic extrachromosomal DNA functions as mobile enhancers to globally amplify chromosomal transcription117
Three subtypes of lung cancer fibroblasts define distinct therapeutic paradigms114
Functional precision oncology: Testing tumors with drugs to identify vulnerabilities and novel combinations113
MLH1 Deficiency-Triggered DNA Hyperexcision by Exonuclease 1 Activates the cGAS-STING Pathway113
Genome-wide CRISPR screens of T cell exhaustion identify chromatin remodeling factors that limit T cell persistence111
SETD2 Restricts Prostate Cancer Metastasis by Integrating EZH2 and AMPK Signaling Pathways111
Dietary Approaches to Cancer Therapy109
N6-Methyladenosine on mRNA facilitates a phase-separated nuclear body that suppresses myeloid leukemic differentiation109
Therapeutic targeting of ATR yields durable regressions in small cell lung cancers with high replication stress109
The landscape of tumor cell states and ecosystems in diffuse large B cell lymphoma108
Human prostate cancer bone metastases have an actionable immunosuppressive microenvironment106
Extensive Remodeling of the Immune Microenvironment in B Cell Acute Lymphoblastic Leukemia106
Reuterin in the healthy gut microbiome suppresses colorectal cancer growth through altering redox balance102
Immunogenomic Landscape of Hematological Malignancies101
Melanoma models for the next generation of therapies100
Targeting pan-essential genes in cancer: Challenges and opportunities99
MAT2A Inhibition Blocks the Growth of MTAP-Deleted Cancer Cells by Reducing PRMT5-Dependent mRNA Splicing and Inducing DNA Damage99
The allergy mediator histamine confers resistance to immunotherapy in cancer patients via activation of the macrophage histamine receptor H199
Redefining breast cancer subtypes to guide treatment prioritization and maximize response: Predictive biomarkers across 10 cancer therapies98
Tumor-associated high endothelial venules mediate lymphocyte entry into tumors and predict response to PD-1 plus CTLA-4 combination immunotherapy98
Integrin αvβ6–TGFβ–SOX4 Pathway Drives Immune Evasion in Triple-Negative Breast Cancer98
Altered RNA Splicing by Mutant p53 Activates Oncogenic RAS Signaling in Pancreatic Cancer97
Single-Cell RNA-Seq Reveals Cellular Hierarchies and Impaired Developmental Trajectories in Pediatric Ependymoma96
Multi-phenotype CRISPR-Cas9 Screen Identifies p38 Kinase as a Target for Adoptive Immunotherapies96
Tim-4+ cavity-resident macrophages impair anti-tumor CD8+ T cell immunity95
Mutant EZH2 Induces a Pre-malignant Lymphoma Niche by Reprogramming the Immune Response94
Simultaneous targeting of TGF-β/PD-L1 synergizes with radiotherapy by reprogramming the tumor microenvironment to overcome immune evasion93
Bevacizumab plus erlotinib in Chinese patients with untreated, EGFR-mutated, advanced NSCLC (ARTEMIS-CTONG1509): A multicenter phase 3 study93
Integrative analysis of drug response and clinical outcome in acute myeloid leukemia92
Cholesterol Pathway Inhibition Induces TGF-β Signaling to Promote Basal Differentiation in Pancreatic Cancer92
Cancer cells escape autophagy inhibition via NRF2-induced macropinocytosis92
Integrated Metabolic and Epigenomic Reprograming by H3K27M Mutations in Diffuse Intrinsic Pontine Gliomas91
Binary pan-cancer classes with distinct vulnerabilities defined by pro- or anti-cancer YAP/TEAD activity91
Increased glucose metabolism in TAMs fuels O-GlcNAcylation of lysosomal Cathepsin B to promote cancer metastasis and chemoresistance90
High-resolution single-cell atlas reveals diversity and plasticity of tissue-resident neutrophils in non-small cell lung cancer90
Hematopoietic Progenitor Kinase1 (HPK1) Mediates T Cell Dysfunction and Is a Druggable Target for T Cell-Based Immunotherapies88
Metabolic programming and immune suppression in the tumor microenvironment86
Acute Immune Signatures and Their Legacies in Severe Acute Respiratory Syndrome Coronavirus-2 Infected Cancer Patients86
Evaluation of cell-free DNA approaches for multi-cancer early detection85
MEK inhibition overcomes chemoimmunotherapy resistance by inducing CXCL10 in cancer cells84
Evolutionary predictability of genetic versus nongenetic resistance to anticancer drugs in melanoma83
Oncogenic collagen I homotrimers from cancer cells bind to α3β1 integrin and impact tumor microbiome and immunity to promote pancreatic cancer83
Tumor-infiltrating regulatory T cells as targets of cancer immunotherapy80
Efficacy of booster doses in augmenting waning immune responses to COVID-19 vaccine in patients with cancer80
Anti-PD-1/L1 lead-in before MAPK inhibitor combination maximizes antitumor immunity and efficacy79
Reduced Mitochondrial Apoptotic Priming Drives Resistance to BH3 Mimetics in Acute Myeloid Leukemia79
Stanniocalcin 1 is a phagocytosis checkpoint driving tumor immune resistance79
PKCλ/ι Loss Induces Autophagy, Oxidative Phosphorylation, and NRF2 to Promote Liver Cancer Progression78
Anti-spike antibody response to SARS-CoV-2 booster vaccination in patients with B cell-derived hematologic malignancies78
Expanding control of the tumor cell cycle with a CDK2/4/6 inhibitor75
Immune checkpoint HLA-E:CD94-NKG2A mediates evasion of circulating tumor cells from NK cell surveillance75
Comprehensive Molecular Characterization Identifies Distinct Genomic and Immune Hallmarks of Renal Medullary Carcinoma74
Telomere Stress Potentiates STING-Dependent Anti-tumor Immunity73
Activity of AZD7442 (tixagevimab-cilgavimab) against Omicron SARS-CoV-2 in patients with hematologic malignancies73
Multiomic profiling of checkpoint inhibitor-treated melanoma: Identifying predictors of response and resistance, and markers of biological discordance73
PARP7 negatively regulates the type I interferon response in cancer cells and its inhibition triggers antitumor immunity73
The Tumor Profiler Study: integrated, multi-omic, functional tumor profiling for clinical decision support72
A phenotypic signature that identifies neoantigen-reactive T cells in fresh human lung cancers72
A High-Resolution Map of Human Enhancer RNA Loci Characterizes Super-enhancer Activities in Cancer72
Exercise-induced engagement of the IL-15/IL-15Rα axis promotes anti-tumor immunity in pancreatic cancer71
Selective Inhibition of STRN3-Containing PP2A Phosphatase Restores Hippo Tumor-Suppressor Activity in Gastric Cancer70
From bench to bedside: Single-cell analysis for cancer immunotherapy69
Myeloid antigen-presenting cell niches sustain antitumor T cells and license PD-1 blockade via CD28 costimulation69
Cytokine Storms in Cancer and COVID-1967
Serial assessment of measurable residual disease in medulloblastoma liquid biopsies67
FOXA1 Mutations Reveal Distinct Chromatin Profiles and Influence Therapeutic Response in Breast Cancer67
Epigenomic Reprogramming as a Driver of Malignant Glioma67
Tumor heterogeneity67
Molecular Features of Cancers Exhibiting Exceptional Responses to Treatment67
Senescence Reprogramming by TIMP1 Deficiency Promotes Prostate Cancer Metastasis66
The m6A reader IGF2BP2 regulates glutamine metabolism and represents a therapeutic target in acute myeloid leukemia66
Cell Lineage-Based Stratification for Glioblastoma65
Oncolytic virotherapy-mediated anti-tumor response: a single-cell perspective64
Neoantigen-specific CD4+ T cells in human melanoma have diverse differentiation states and correlate with CD8+ T cell, macrophage, and B cell function64
GPC2-CAR T cells tuned for low antigen density mediate potent activity against neuroblastoma without toxicity63
Pan-cancer proteomic map of 949 human cell lines62
The AML microenvironment catalyzes a stepwise evolution to gilteritinib resistance62
Targeting RSPO3-LGR4 Signaling for Leukemia Stem Cell Eradication in Acute Myeloid Leukemia60
Molecular classification and diagnostics of upper urinary tract urothelial carcinoma60
Ovarian cancer immunogenicity is governed by a narrow subset of progenitor tissue-resident memory T cells60
Multiomic analysis reveals conservation of cancer-associated fibroblast phenotypes across species and tissue of origin60
Targeting Aurora B kinase prevents and overcomes resistance to EGFR inhibitors in lung cancer by enhancing BIM- and PUMA-mediated apoptosis59
Variable cellular responses to SARS-CoV-2 in fully vaccinated patients with multiple myeloma59
Innate immune cells in the tumor microenvironment59
IL-5-producing CD4+ T cells and eosinophils cooperate to enhance response to immune checkpoint blockade in breast cancer58
Single-cell landscapes of primary glioblastomas and matched explants and cell lines show variable retention of inter- and intratumor heterogeneity58
Non-cleavable hinge enhances avidity and expansion of CAR-T cells for acute myeloid leukemia57
Unbiased Proteomic Profiling Uncovers a Targetable GNAS/PKA/PP2A Axis in Small Cell Lung Cancer Stem Cells57
H3.3-K27M drives neural stem cell-specific gliomagenesis in a human iPSC-derived model55
Activated fibroblasts in cancer: Perspectives and challenges54
Transcriptomic profiles of neoantigen-reactive T cells in human gastrointestinal cancers54
B cells and cancer53
Personalized neoantigen vaccine NEO-PV-01 with chemotherapy and anti-PD-1 as first-line treatment for non-squamous non-small cell lung cancer53
Cathepsin S Regulates Antigen Processing and T Cell Activity in Non-Hodgkin Lymphoma53
Inflammatory Leptomeningeal Cytokines Mediate COVID-19 Neurologic Symptoms in Cancer Patients53
Tumor microbiome links cellular programs and immunity in pancreatic cancer51
The therapeutic window of antibody drug conjugates: A dogma in need of revision51
COVID-19 mRNA booster vaccines elicit strong protection against SARS-CoV-2 Omicron variant in patients with cancer51
Cancer Care Disparities during the COVID-19 Pandemic: COVID-19 and Cancer Outcomes Study51
Precise reconstruction of the TME using bulk RNA-seq and a machine learning algorithm trained on artificial transcriptomes51
The pre-existing T cell landscape determines the response to bispecific T cell engagers in multiple myeloma patients50
STAG2 loss rewires oncogenic and developmental programs to promote metastasis in Ewing sarcoma50
Interleukin-1 in tumor progression, therapy, and prevention50
TRIM8 modulates the EWS/FLI oncoprotein to promote survival in Ewing sarcoma50
STAG2 mutations alter CTCF-anchored loop extrusion, reduce cis-regulatory interactions and EWSR1-FLI1 activity in Ewing sarcoma50
SETD5-Coordinated Chromatin Reprogramming Regulates Adaptive Resistance to Targeted Pancreatic Cancer Therapy50
Spatial profiling technologies illuminate the tumor microenvironment50
Ancestry-driven recalibration of tumor mutational burden and disparate clinical outcomes in response to immune checkpoint inhibitors49
Leveraging self-assembled nanobiomaterials for improved cancer immunotherapy49
Functional Genomics for Cancer Drug Target Discovery47
Immune responses following third COVID-19 vaccination are reduced in patients with hematological malignancies compared to patients with solid cancer46
Multi-omic analyses of changes in the tumor microenvironment of pancreatic adenocarcinoma following neoadjuvant treatment with anti-PD-1 therapy46
Tumor-induced erythroid precursor-differentiated myeloid cells mediate immunosuppression and curtail anti-PD-1/PD-L1 treatment efficacy46
Histopathologic and proteogenomic heterogeneity reveals features of clear cell renal cell carcinoma aggressiveness46
Clinical application of advanced multi-omics tumor profiling: Shaping precision oncology of the future46
TERAVOLT: Thoracic Cancers International COVID-19 Collaboration46
Interferon-dependent SLC14A1+ cancer-associated fibroblasts promote cancer stemness via WNT5A in bladder cancer46
Mapping single-cell transcriptomes in the intra-tumoral and associated territories of kidney cancer46
Immune responses to COVID-19 vaccines in patients with cancer: Promising results and a note of caution45
Cancer Patient Care during COVID-1945
COVID-19: Staging of a New Disease45
Isotype Switching Converts Anti-CD40 Antagonism to Agonism to Elicit Potent Antitumor Activity45
MAX Functions as a Tumor Suppressor and Rewires Metabolism in Small Cell Lung Cancer45
The translational challenges of precision oncology45
The proteogenomic subtypes of acute myeloid leukemia44
De novo pyrimidine synthesis is a targetable vulnerability in IDH mutant glioma44
Cancer immunotherapies transition endothelial cells into HEVs that generate TCF1+ T lymphocyte niches through a feed-forward loop43
Poziotinib for EGFR exon 20-mutant NSCLC: Clinical efficacy, resistance mechanisms, and impact of insertion location on drug sensitivity43
Neutrophil extracellular traps formed during chemotherapy confer treatment resistance via TGF-β activation43
Humoral and cellular immune responses in SARS-CoV-2 mRNA-vaccinated patients with cancer42
Co-occurring gain-of-function mutations in HER2 and HER3 modulate HER2/HER3 activation, oncogenesis, and HER2 inhibitor sensitivity42
A covalent inhibitor of K-Ras(G12C) induces MHC class I presentation of haptenated peptide neoepitopes targetable by immunotherapy42
Normal Somatic Mutations in Cancer Transformation42
Integrated multi-omics profiling yields a clinically relevant molecular classification for esophageal squamous cell carcinoma42
The role of exhaustion in CAR T cell therapy40
Evaluation of TMB as a predictive biomarker in patients with solid cancers treated with anti-PD-1/CTLA-4 combination immunotherapy40
The COVID-19 and Cancer Consortium: A Collaborative Effort to Understand the Effects of COVID-19 on Patients with Cancer40
Transcriptome analysis reveals tumor microenvironment changes in glioblastoma39
FOXA2 drives lineage plasticity and KIT pathway activation in neuroendocrine prostate cancer39
Neutrophil-activating therapy for the treatment of cancer39
High-performance multiplex drug-gated CAR circuits39
NKG2A and HLA-E define an alternative immune checkpoint axis in bladder cancer39
New genomic technologies for multi-cancer early detection: Rethinking the scope of cancer screening38
Large-Scale Characterization of Drug Responses of Clinically Relevant Proteins in Cancer Cell Lines38
Elimination of fluorescent protein immunogenicity permits modeling of metastasis in immune-competent settings38
Metabolic Imaging Detects Resistance to PI3Kα Inhibition Mediated by Persistent FOXM1 Expression in ER+ Breast Cancer37
Tumor Mutational Burden as a Pan-cancer Biomarker for Immunotherapy: The Limits and Potential for Convergence36
Determinants of resistance to engineered T cell therapies targeting CD19 in large B cell lymphomas36
Cancer hallmarks intersect with neuroscience in the tumor microenvironment36
Cancer Patients and Risk of Mortality for COVID-1936
Efficacy of a third SARS-CoV-2 mRNA vaccine dose among hematopoietic cell transplantation, CAR T cell, and BiTE recipients36
Expanding the Role for Immunotherapy in Triple-Negative Breast Cancer35
Intersection of immune and oncometabolic pathways drives cancer hyperprogression during immunotherapy34
A druggable addiction to de novo pyrimidine biosynthesis in diffuse midline glioma34
Detection and localization of early- and late-stage cancers using platelet RNA34
Ablation of the endoplasmic reticulum stress kinase PERK induces paraptosis and type I interferon to promote anti-tumor T cell responses33
A Deregulated HOX Gene Axis Confers an Epigenetic Vulnerability in KRAS-Mutant Lung Cancers33
Functional states of myeloid cells in cancer33
NETworking with cancer: The bidirectional interplay between cancer and neutrophil extracellular traps33
Challenges in neoantigen-directed therapeutics32
Platelets control liver tumor growth through P2Y12-dependent CD40L release in NAFLD32
Neoadjuvant immune checkpoint blockade: A window of opportunity to advance cancer immunotherapy32
MPS1 inhibition primes immunogenicity of KRAS-LKB1 mutant lung cancer32
Cancer cell autophagy, reprogrammed macrophages, and remodeled vasculature in glioblastoma triggers tumor immunity32
Tumor PD-L1 engages myeloid PD-1 to suppress type I interferon to impair cytotoxic T lymphocyte recruitment31
Impact of COVID-19 on case fatality rate of patients with cancer during the Omicron wave31
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