Cancer Cell

Article	Citations
TAMing immunity through an unexpected source	3442
Olfactory neuroblastoma mimics molecular heterogeneity and lineage trajectories of small-cell lung cancer	633
The Polycomb Repressor Complex 1 Drives Double-Negative Prostate Cancer Metastasis by Coordinating Stemness and Immune Suppression	572
Hand in hand to successful immunotherapy: CD8+ T cells and M1-like macrophages swap the baton	547
Loss of SYNCRIP unleashes APOBEC-driven mutagenesis, tumor heterogeneity, and AR-targeted therapy resistance in prostate cancer	527
Bnip3L is induced by p53 under hypoxia, and its knockdown promotes tumor growth	503
EGFR-activated myofibroblasts promote metastasis of pancreatic cancer	480
A snapshot of the earliest stages of hepatocellular carcinoma	476
Characterization of the generic mutant p53-rescue compounds in a broad range of assays	466
Accelerated approvals: Early-phase success or premature authorization?	445
KIT as a therapeutic target in neuroendocrine prostate cancer	411
Molecular targets of glucocorticoids that elucidate their therapeutic efficacy in aggressive lymphomas	410
Dendritic cell redundancy enables priming of anti-tumor CD4+ T cells in pancreatic cancer	379
Tissue factor is a critical regulator of radiation therapy-induced glioblastoma remodeling	360
A stratification system for breast cancer based on basoluminal tumor cells and spatial tumor architecture	349
Multimodal spatial-omics reveal co-evolution of alveolar progenitors and proinflammatory niches in progression of lung precursor lesions	329
IL-36γ armored CAR T cells reprogram neutrophils to induce endogenous antitumor immunity	319
Lymphoma accelerates T cell and tissue aging	318
KMT2D deficiency drives lung squamous cell carcinoma and hypersensitivity to RTK-RAS inhibition	308
Long-range cholinergic input promotes glioblastoma progression	297
Dynamic circulating tumor DNA during chemoradiotherapy predicts clinical outcomes for locally advanced non-small cell lung cancer patients	296
Diet-microbiome interactions in cancer	294
Spatial profiling technologies illuminate the tumor microenvironment	291
The aging lung microenvironment awakens melanoma metastases	285
Impaired humoral immunity is associated with prolonged COVID-19 despite robust CD8 T cell responses	269

T cell dynamism and immune-related adverse events	257
A Lymphotoxin-Driven Pathway to Hepatocellular Carcinoma	249
Challenges in neoantigen-directed therapeutics	245
Genetic modeling of ELP1-associated Sonic hedgehog medulloblastoma identifies MDM2 as a selective therapeutic target	239
Targeting P4HA1 promotes CD8+ T cell progenitor expansion toward immune memory and systemic anti-tumor immunity	237
Elucidating acquired PARP inhibitor resistance in advanced prostate cancer	236
Multiomic analysis reveals conservation of cancer-associated fibroblast phenotypes across species and tissue of origin	235
B cell heterogeneity in cancer comes of age	235
Cancer vaccines	226
Bacteria in metastatic sites: Unveiling hidden players in cancer progression	221
When the methylome becomes the microscope	218
T-Lymphoblastic Lymphoma Cells Express High Levels of BCL2, S1P1, and ICAM1, Leading to a Blockade of Tumor Cell Intravasation	218
Kupffer Cell-Derived Tnf Triggers Cholangiocellular Tumorigenesis through JNK due to Chronic Mitochondrial Dysfunction and ROS	215
Immune biomarkers of response to immunotherapy in patients with high-risk smoldering myeloma	214
Intratumoral immune triads are required for immunotherapy-mediated elimination of solid tumors	214
Sensory neurons drive pancreatic cancer progression through glutamatergic neuron-cancer pseudo-synapses	211
Fusobacterium nucleatum facilitates anti-PD-1 therapy in microsatellite stable colorectal cancer	208
Apolipoprotein E induces pathogenic senescent-like myeloid cells in prostate cancer	208
Identification of cycling regulatory T cell precursors as conductors of immune escape during breast carcinoma progression	204
High endothelial venules in cancer: Regulation, function, and therapeutic implication	202
Antiandrogen treatment induces stromal cell reprogramming to promote castration resistance in prostate cancer	201
A holistic view of cancer	201
Spatiotemporal single-cell analysis decodes cellular dynamics underlying different responses to immunotherapy in colorectal cancer	199
Prior anti-CTLA-4 therapy impacts molecular characteristics associated with anti-PD-1 response in advanced melanoma	194
Targeting STING to generate therapeutic anti-tumor immunity	194
A genetic portrait of metastatic seeds in lung adenocarcinoma	193
Gut microbes promote chemoradiotherapy resistance via metabolic cross-feeding	193
Are we ready to look beyond plasma cells in assessing high-risk smoldering myeloma?	193
Tumor-directed dysregulation of erythroid progenitors drives immunosuppressive myeloid cells	190
Distinct T cell functions enable efficient immunoediting and prevent tumor emergence of developing sarcomas	188
Revisiting TNM staging for EBV-related nasopharyngeal carcinoma	185
The one-two punch: TIM-3 blockade targets immune and tumor cells to knock out pediatric brain tumors	182
Challenges and opportunities for modeling aging and cancer	181
Immunosensitivity cuts across mismatch repair status in colorectal cancer	181
Molecular classification and biomarkers of clinical outcome in breast ductal carcinoma in situ: Analysis of TBCRC 038 and RAHBT cohorts	180
Spatial proteo-transcriptomic profiling reveals the molecular landscape of borderline ovarian tumors and their invasive progression	180
Lymphocyte networks are dynamic cellular communities in the immunoregulatory landscape of lung adenocarcinoma	175
Evolutionary landscape of clonal hematopoiesis in 3,359 individuals from the general population	175
Neutralizing IL-8 potentiates immune checkpoint blockade efficacy for glioma	174
Mammalian SWI/SNF complex activity regulates POU2F3 and constitutes a targetable dependency in small cell lung cancer	170
Temporal evolution reveals bifurcated lineages in aggressive neuroendocrine small cell prostate cancer trans-differentiation	168
Immunotherapy-activated T cells recruit and skew late-stage activated M1-like macrophages that are critical for therapeutic efficacy	168
Circular RMST cooperates with lineage-driving transcription factors to govern neuroendocrine transdifferentiation	166
Clinical significance and biology of circulating tumor DNA in high-risk early-stage HER2-negative breast cancer receiving neoadjuvant chemotherapy	165
Conserved spatial subtypes and cellular neighborhoods of cancer-associated fibroblasts revealed by single-cell spatial multi-omics	163
Multi-omic profiling of follicular lymphoma reveals changes in tissue architecture and enhanced stromal remodeling in high-risk patients	163
Integrated single-cell and spatial transcriptomics uncover distinct cellular subtypes involved in neural invasion in pancreatic cancer	163
Hypoxia inducible factor-1α drives cancer resistance to cuproptosis	159
Response-based molecular subtyping—emergence of the third generation of breast cancer subtypes	158
A conserved, terminal, pro-tumor neutrophil population	158

Ubiquitin control of cytosolic DNA sets immune responses to DNA damage	158
Framework for cancer evolution profiling and interception in colorectal cancer: ASCEND-CRC program	157
Tumor sequencing of African ancestry reveals differences in clinically relevant alterations across common cancers	156
Tumor-intrinsic SIRPA promotes sensitivity to checkpoint inhibition immunotherapy in melanoma	151
Inhibiting intracellular CD28 in cancer cells enhances antitumor immunity and overcomes anti-PD-1 resistance via targeting PD-L1	151
Circulating tumor DNA as a biomarker in early phase clinical trials	150
T cell extracellular vesicles go nuclear to turn cold tumors hot	150
Interleukin-21 engineering enhances NK cell activity against glioblastoma via CEBPD	150
Immune determinants of the pre-metastatic niche	148
Knowledge-enhanced pretraining for vision-language pathology foundation model on cancer diagnosis	148
Tumor-infiltrating lymphocytes: A new hope	148
Tumor-resident Lactobacillus iners confer chemoradiation resistance through lactate-induced metabolic rewiring	147
Chronic stress increases metastasis via neutrophil-mediated changes to the microenvironment	146
Midkine as a driver of age-related changes and increase in mammary tumorigenesis	142
Characterization of a pathogenic subpopulation of human glioma associated macrophages linked to glioma progression	137
Integrated proteogenomic characterization of glioblastoma evolution	136
Single-cell multi-stage spatial evolutional map of esophageal carcinogenesis	135
A path to translation: How 3D patient tumor avatars enable next generation precision oncology	134
Precise patient stratification in esophageal cancer: Biomarkers for immunochemotherapy	133
Histopathologic and proteogenomic heterogeneity reveals features of clear cell renal cell carcinoma aggressiveness	133
A circular RNA in neuroendocrine carcinomas	133
GDF15 research from bench to bedside	132
Taxanes directly induce T cell cytotoxic extracellular vesicles to eradicate tumor cells	129
Firing up neutrophil anti-tumor immunity with cocktails	126
T cell immune deficiency rather than chromosome instability predisposes patients with short telomere syndromes to squamous cancers	125
Risk factors for poor humoral response to primary and booster SARS-CoV-2 vaccination in hematologic and oncological outpatients—COVIDOUT study	125
New horizons at the interface of artificial intelligence and translational cancer research	124
JYP0322, a highly selective and brain-penetrant ROS1 inhibitor, overcomes ROS1G2032R resistance mutation in NSCLC: The first-in-human phase 1 trial	124
Tumors on different wavelengths	124
Effect of neoadjuvant chemoradiotherapy with or without PD-1 antibody sintilimab in pMMR locally advanced rectal cancer: A randomized clinical trial	123
The winner takes it all: Competition drives clonal selection in gliomagenesis	122
IRF4 requires ARID1A to establish plasma cell identity in multiple myeloma	119
Distinct spatiotemporal dynamics of CD8+ T cell-derived cytokines in the tumor microenvironment	118
CSF1R+ myeloid-monocytic cells drive CAR-T cell resistance in aggressive B cell lymphoma	117
A tumor-associated photoreceptor signature unifies distinct central nervous system malignancies	117
Exercise-induced engagement of the IL-15/IL-15Rα axis promotes anti-tumor immunity in pancreatic cancer	116
Progenitor-like exhausted SPRY1+CD8+ T cells potentiate responsiveness to neoadjuvant PD-1 blockade in esophageal squamous cell carcinoma	111
Immunosequencing identifies signatures of T cell responses for early detection of nasopharyngeal carcinoma	110
Tumor-infiltrating bacteria disrupt cancer epithelial cell interactions and induce cell-cycle arrest	110
Increased glucose metabolism in TAMs fuels O-GlcNAcylation of lysosomal Cathepsin B to promote cancer metastasis and chemoresistance	110
Proteogenomic data and resources for pan-cancer analysis	109
When blood mutations turn beneficial	109
Integrated single cell analysis reveals co-evolution of malignant B cells and tumor micro-environment in transformed follicular lymphoma	107
Hidden spark: From cold to hot in BRAF colorectal cancer	107
GD2-CAR T cells in patients with osteosarcoma and neuroblastoma—it’s not only the T cells that matter	105
Cellular senescence in precancer lesions and early-stage cancers	105
Enhanced but variant-dependent serological and cellular immune responses to third-dose BNT162b2 vaccination in patients with multiple myeloma	105
Spatial transcriptomics reveals tryptophan metabolism restricting maturation of intratumoral tertiary lymphoid structures	104
Cisplatin and temozolomide combinatorial treatment triggers hypermutability and immune surveillance in experimental cancer models	104
KEAP1 and STK11/LKB1 alterations enhance vulnerability to ATR inhibition in KRAS mutant non-small cell lung cancer	104
Gut microbiota-mediated nucleotide synthesis attenuates the response to neoadjuvant chemoradiotherapy in rectal cancer	103
Integrative plasma and fecal metabolomics identify functional metabolites in adenoma-colorectal cancer progression and as early diagnostic biomarkers	103
Intratumoral CD8+ T cells with a tissue-resident memory phenotype mediate local immunity and immune checkpoint responses in breast cancer	103
An immunogenic and oncogenic feature-based classification for chemotherapy plus PD-1 blockade in advanced esophageal squamous cell carcinoma	103
Lymph node colonization induces tissue remodeling via immunosuppressive fibroblast-myeloid cell niches supporting metastatic tolerance	103
Getting a handle on KRAS inhibitor resistance with hapten-mediated anti-tumor immunity	102
Stromal barriers to the abscopal effect	102
From intestinal metaplasia to gastric cancer: Witnessing the rise of evil over time and space	100
Engineering myeloid cells for cancer immunotherapy	99
PD-1 blockade is a promising therapeutic addition to neoadjuvant chemoradiation in locally advanced rectal cancer	98
Neoadjuvant treatment of IBI310 plus sintilimab in locally advanced MSI-H/dMMR colon cancer: A randomized phase 1b study	98
Adiponectin reduces immune checkpoint inhibitor-induced inflammation without blocking anti-tumor immunity	96
Squamous cell cancers of the aero-upper digestive tract: A unified perspective on biology, genetics, and therapy	95
Phenotypic signatures of circulating neoantigen-reactive CD8+ T cells in patients with metastatic cancers	95
Horizontal mitochondrial transfer in cancer biology: Potential clinical relevance	95
Plasma cell and cancer stem cell crosstalk in glioblastoma	94
The intratumor mycobiome promotes lung cancer progression via myeloid-derived suppressor cells	93
Targeting internalization, resistance, and response: Insights from ICARUS-LUNG01	93
Macrophages: Targets for next-generation cancer immunotherapy	90
Isocitrate dehydrogenase 1 primes group-3 medulloblastomas for cuproptosis	90
Integrative analysis of neuroblastoma by single-cell RNA sequencing identifies the NECTIN2-TIGIT axis as a target for immunotherapy	90
Tumor microbiome links cellular programs and immunity in pancreatic cancer	90
High-resolution single-cell atlas reveals diversity and plasticity of tissue-resident neutrophils in non-small cell lung cancer	90
Stromal lipid species dictate melanoma metastasis and tropism	89
Glioblastoma induces the recruitment and differentiation of dendritic-like “hybrid” neutrophils from skull bone marrow	89
When immunotherapy meets surgery in non-small cell lung cancer	88
When essential metal elements become culprits—Cuproptosis in focus	88
Infiltrating plasma cells maintain glioblastoma stem cells through IgG-Tumor binding	88
Spatial patterns of glioblastoma	85
Revealing de novo pyrimidine synthesis as a key vulnerability in brain tumors	85

Arsenic Trioxide Rescues Structural p53 Mutations through a Cryptic Allosteric Site	83
The Terry Fox Research Institute Marathon of Hope Cancer Centres Network: A pan-Canadian precision oncology initiative	83
Architecture sets the path: Breast cancer subtypes differently shape the early brain metastatic niche	83
Selective inhibition of tumor microvascular permeability by cavtratin blocks tumor progression in mice	82
Adoptively transferred Th17 cells cooperate with host B cells to achieve durable tumor immunity	81
RAS-ing the bar in the treatment of KRAS-mutant cholangiocarcinoma	81
Identification of specific PP2A complexes involved in human cell transformation	80
Combining personalized neoantigen vaccination with chemotherapy and anti-PD-1 to treat NSCLC	80
Vascular characterization reveals immunomodulatory targets for brain metastases	80
Fusobacterium nucleatum facilitates anti-PD-1 therapy in microsatellite stable colorectal cancer	77
Armored macrophage-targeted CAR-T cells reset and reprogram the tumor microenvironment and control metastatic cancer growth	77
Multi-omic landscape of human gliomas from diagnosis to treatment and recurrence	77
Increased antibody titers and reduced seronegativity following fourth mRNA COVID-19 vaccination in patients with cancer	76
Cancer type-specific variation in patterns of driver alterations across 50,000 tumors	75
Spatiotemporal genomic profiling of intestinal metaplasia reveals clonal dynamics of gastric cancer progression	75
Genomic mapping of metastatic organotropism in lung adenocarcinoma	75
Comprehensive tumor-immune profiling reveals mediators of paradoxical immune sensitivity in sarcomatoid renal cell carcinoma	75
Spatial omics at the forefront: emerging technologies, analytical innovations, and clinical applications	74
A druggable addiction to de novo pyrimidine biosynthesis in diffuse midline glioma	74
A first-in-class EGFR-directed KRAS G12V selective inhibitor	73
TIM3+ breast cancer cells license immune evasion during micrometastasis outbreak	73
Subclonal immune evasion in non-small cell lung cancer	73
Nivolumab combined with induction chemotherapy and radiotherapy in nasopharyngeal carcinoma: A multicenter phase 2 PLATINUM trial	73
B cells disrupt tertiary lymphoid structure formation and suppress anti-tumor immunity	73
Bridging the gap: The future of cancer research and clinical oncology in Cancer Cell	72
Immune memory shapes ovarian cancer recurrence	72
Mapping single-cell transcriptomes in the intra-tumoral and associated territories of kidney cancer	72
A Prostatic Intraepithelial Neoplasia-Dependent p27Kip1 Checkpoint Induces Senescence and Inhibits Cell Proliferation and Cancer Progression	72
The liver as a cytokine factory working on mRNA blueprints for cancer immunotherapy	72
Rethinking immune states in brain metastasis	72
A proteogenomic surfaceome study identifies DLK1 as an immunotherapeutic target in neuroblastoma	71
Overcoming melanoma therapy resistance with RAF-MEK and FAK inhibition	71
Mutations in IFN-γ signaling genes sensitize tumors to immune checkpoint blockade	70
Sex and cancer immunotherapy: Current understanding and challenges	69
Engineered enhancers: Using tumor switches for precision therapy	69
Understanding and reversing mammary tumor-driven reprogramming of myelopoiesis to reduce metastatic spread	69
Neutrophil-activating therapy for the treatment of cancer	69
A longitudinal single-cell atlas to predict outcome and toxicity after BCMA-directed CAR T cell therapy in multiple myeloma	69
Reimagining HER2 therapy: Bridging oncogene addiction and immune modulation	69
The coming era of nudge drugs for cancer	67
Contrasting cytotoxic and regulatory T cell responses underlying distinct clinical outcomes to anti-PD-1 plus lenvatinib therapy in cancer	66
Cancer-selective metabolic vulnerabilities in MYC-amplified medulloblastoma	65
Enzyme-mediated depletion of methylthioadenosine restores T cell function in MTAP-deficient tumors and reverses immunotherapy resistance	65
Cooperative CAR targeting to selectively eliminate AML and minimize escape	64
Carnobacterium maltaromaticum boosts intestinal vitamin D production to suppress colorectal cancer in female mice	64
Engineered natural killer cells for cancer therapy	64
Simultaneous targeting of PD-1 and IL-2Rβγ with radiation therapy inhibits pancreatic cancer growth and metastasis	63
Insights into the co-evolution of epithelial cells and fibroblasts in the esophageal tumor microenvironment	63
IDH2 and TET2 mutations synergize to modulate T Follicular Helper cell functional interaction with the AITL microenvironment	63
Metabolic regulation of Cathepsin B in tumor macrophages drives their pro-metastatic function	63