Toxicology Mechanisms and Methods

Article	Citations
An improved method for toxicological profiling of chemical substances	157
PARP-1 inhibits DNMT1-mediated promoter methylation and promotes linc01132 expression in benzene-exposed workers and hydroquinone-induced malignant transformed cells	37
Evaluation of the protective effects of curcumin-rich turmeric ( Curcuma longa ) extract against isotretinoin-induced liver damage in rats	36
Human stromal cell-based protocol to generate astrocytes: a straightforward in vitro predictive strategy in neurotoxicology	31
Neuroprotective effect of taxifolin against aluminum chloride-induced dementia and pathological alterations in the brain of rats: possible involvement of toll-like receptor 4	30
Potential of paracetamol for reproductive disruption: molecular interaction, dynamics, and MM-PBSA based in-silico assessment	30
Salinomycin induces cell cycle arrest and apoptosis and modulates hepatic cytochrome P450 mRNA expression in HepG2/C3a cells	27
Effects of acute carbon monoxide poisoning on liver damage and comparisons of related oxygen therapies in a rat model	26
Effects of nano-titanium dioxide on calcium homeostasisin vivoandin vitro: a systematic review and meta-analysis	23
Chronological activation of the NLRP3 inflammasome/pyroptosis pathway in the progression from metabolic dysfunction-associated fatty liver disease to hepatocellular carcinoma	22
A simple protocol for estimating the acute toxicity of unresolved polar compounds from field-weathered oils	21
Flow-through imaging and automated analysis of oil-exposed early stage Atlantic cod ( Gadus morhua )	17
Cadmium-induced pancreatic toxicity in rats: comparing vitamin C and Nigella sativa as protective agents: a histomorphometric and ultrastructural study	17
Maternal long-term inhalation exposure to perchloroethylene and prenatal teratogenicity: morphometric, hormonal, and histological study	15
Neuroprotective effect ofBryophyllum pinnatumflavonoids against aluminum chloride-induced neurotoxicity in rats	15
Evaluating the protective role of Deglycyrrhizinated licorice root supplement on bleomycin induced pulmonary oxidative damage	15
Implications of plastic-derived endocrine disruptors on human health	14
Development a high-throughput zebrafish embryo acute toxicity testing method based on OECD TG 236	14
Mechanistic paradigms of immunotoxicity, triggered by nanoparticles – a review	14
Alcohol-induced hormonal and metabolic alterations in plasma and erythrocytes—a gender-based study	13
Establishing a link between the chemical composition and biological activities of Gladiolus italicus Mill. from the Turkish flora utilizing in vitro	13
Toxicological impact of copper nanoparticles on rainbow trout: hematological, biochemical, antioxidant, and histopathological responses with oxidative gene expression	12
Correction	12
Leveraging AlphaFold models to predict androgenic effects of endocrine-disrupting chemicals through zebrafish androgen receptor analysis	12
Toxicoproteomics reveals an effect of clozapine on autophagy in human liver spheroids	12

Mitochondrial toxic prediction of marine alga toxins using a predictive model based on feature coupling and ensemble learning algorithms	12
Correction	12
Time-course cross-species transcriptomics reveals conserved hepatotoxicity pathways induced by repeated administration of cyclosporine A	11
Dexamethasone as an anti-cancer or hepatotoxic	11
Evaluation of cytotoxicity, analysis of metals and cumulative risk assessment in microalgae	11
The protective effect of co-administration of platelet-rich plasma (PRP) and pentoxifylline (PTX) on cyclophosphamide-induced premature ovarian failure in mature and immature rats	11
Precision-cut liver slices as a model for assess hepatic cellular response of chitosan–glutathione nanoparticles on cultures treated with zilpaterol and clenbuterol	10
Bioinformatics analysis of differentially expressed genes related to ischemia and hypoxia in spinal cord injury and construction of miRNA-mRNA or mRNA-transcription factor interaction network	10
Decoding the possible mechanism of action of Paeoniflorigenone in combating Aflatoxin B1-induced liver cancer: an investigation using network pharmacology and bioinformatics analysis	10
The stability of cyanide in human biological samples. A systematic review, meta-analysis and determination of cyanide (GC-QqQ-MS/MS) in an authentic casework 7 years after fatal intoxication	10
PM 2.5 -induced DNA oxidative stress in A549 cells and regulating mechanisms by GST DNA methylation and Keap1/Nrf2 pathway	9
Aloe-emodin upregulates DUSP1 to alleviate aristolochic acid-induced renal tubular epithelial cell damage	9
Topiramate affords neuroprotection in diabetic neuropathy model via downregulating spinal GFAP/inflammatory burden and improving neurofilament production	9
Third party product certification for drinking water health effects	9
Potential risk of premature ovarian insufficiency from atrazine exposure: insights into molecular pathways and regulatory implications	8
Molecular signatures associated with diuron exposure on rat urothelial mitochondria	8
Therapeutic and prophylactic role of vitamin D and curcumin in acetic acid-induced acute ulcerative colitis model	8
Should ebselen be considered for the treatment of mercury intoxication? A minireview	8
Investigation of some metal levels in people using electronic cigarettes and IQOS	8
Significant shifts in preclinical and clinical neurotoxicology: a review and commentary	8
Behavioral Pharmacology and Toxicology of Dimethyl Sulfoxide in Artemia nauplii : Vehicle or positive control?	8
Nano and microplastics: unveiling their profound impact on endocrine health	8
Diacerein counteracts amiodarone‑induced hepatotoxicity in rats via targeting TLR4/NF-kB/NLRP3 pathways	8
PM2.5 mediates mouse testis Sertoli TM4 cell damage by reducing cellular NAD +	8
Implications of Withaferin A for the metastatic potential and drug resistance in hepatocellular carcinoma cells via Nrf2-mediated EMT and ferroptosis	8
Studies on pharmacokinetic properties and intestinal absorption mechanism of sanguinarine chloride: in vivo and in situ	7
Effects of pumpkin and fermented whey on fecal microbiota profile against AFB1 and OTA exposure in Wistar rats	7
Does the accounting of the local symmetry fragments in quasi-SMILES improve the predictive potential of the QSAR models of toxicity toward tadpoles?	7
Use of TLM derived models to estimate toxicity of weathered MC252 oil based on conventional chemical data and the potential impact of unresolved polar components	7
5-Hydroxymethylfurfural causes reproductive toxicity in male mice by increasing oxidative stress and apoptosis through the Nrf2/HO-1 signaling pathway	7
Evaluation of acute, subacute, subchronic, reproductive, and genotoxicity of a standardized extract from the bark of Oroxylum indicum	7
Quantitative structure–toxicity relationship models for predication of toxicity of ionic liquids toward leukemia rat cell line IPC-81 based on index of ideality of correlation	7
In silico aquatic toxicity prediction of chemicals toward Daphnia magna and fathead minnow using Monte Carlo approaches	7
Defective mitophagy and induction of apoptosis by the depleted levels of PINK1 and Parkin in Pb and β-amyloid peptide induced toxicity	6
Application of three-dimensional Raman imaging to determination of the relationship between cellular localization of diesel exhaust particles and the toxicity	6
Exposure to di (2-ethylhexyl) phthalate causes locomotor increase and anxiety-like behavior via induction of oxidative stress in brain	6
Exposure to phagolysosomal simulated fluid altered the cytotoxicity of PET micro(nano)plastics to human lung epithelial cells	6
Evidence of binding between diethylstilbestrol (DES) and the goldfish ( Carassius auratus ) membrane progesterone receptor α	6
Differences in metabolite genotoxicity test results of rat liver S9 microsomes treated with various microsomal enzyme inducers	6
Modulating oxidative stress, apoptosis, and mitochondrial dysfunctions on cardiotoxicity induced by aluminum phosphide pesticide using resveratrol	6
Development of a standard operating procedure for the DCFH2-DA acellular assessment of reactive oxygen species produced by nanomaterials	6
Integrated transcriptomic and proteomic analyses reveal the effects of chronic benzene exposure on the central nervous system in mice	6
Effects of imidacloprid on viability and increase of reactive oxygen and nitrogen species in HepG2 cell line	6
Clinical and safety outcomes associated with aristolochic acid exposure: a systematic review and meta-analysis	6
Effects of organophosphates on precision-cut kidney slices	6
An in silico toxicogenomic approach in constructing the aflatoxin B1-mediated regulatory network of hub genes in hepatocellular carcinoma	6
Perinatal exposure to the immune-suppressant di-n-octyltin dichloride affects brain development in rats	6
Chronic oral exposure of aluminum chloride in rat modulates molecular and functional neurotoxic markers relevant to Alzheimer’s disease	6
Development of mass spectrometric methods for determination of desoxycorticosterone pivalate and its esterase product in canine serum	6
The regulatory effects of pomiferin dietary on nickel-induced hepatic injury in Sprague–Dawley rats; action mechanisms and signaling pathways	6

Ellagic acid inhibits proinflammatory intermediary manufacture by suppressing NF-κB/Akt, VEGF and activating Nrf-2/Caspase-3 signaling pathways in rat testicular damage: a new way for testicular damag	6
Evaluation of possible cytotoxic, genotoxic and epigenotoxic effects of titanium dioxide nanoparticles and possible protective effect of melatonin	5
The flavonoid hyperoside attenuates the toxic effect of cisplatin on the human ovarian granulosa cells: in vitro model study	5
Comparison of different QT correction methods for nonclinical safety assessment in ketamine-anesthetized Indian rhesus monkeys (Macaca mulatta)	5
Integrating network pharmacology and in vitro model to investigate hippocampal neurotoxicity induced by atrazine	5
Antioxidant and antihyperlipidemic activities of catechol derivatives and biflavonoid isolated from Semecarpus anacardium seeds	5
Comparison of carcinogenic potential of alternative tobacco products. A systematic review	5
Deferoxamine ameliorated Al(mal)3-induced neuronal ferroptosis in adult rats by chelating brain iron to attenuate oxidative damage	5
Agomelatine ameliorates doxorubicin-induced cortical and hippocampal brain injury via inhibition of TNF-alpha/NF-kB pathway	5
Enhanced kidney damage induced by increasing nonylphenol doses: impact on autophagy-related proteins and proinflammatory cytokines in rats	5
Enhanced anti-cancer efficacy of Sorafenib and Pioglitazone via VEGF inhibition in DMBA-induced breast cancer model	5
Safety assessment of high fructose corn syrup and fructose used as sweeteners in foods	5
Molecular heterogeneity in pediatric sepsis: identification of oxidative stress-related subtypes and diagnostic biomarkers through integrated bioinformatics analysis	5
Protective effects of polysaccharide extracted from green alga Chaetomorpha linum against zinc and copper-induced testicular toxicity in male mice	4
Neuroprotective effect of Morin via TrkB/Akt pathway against diabetes mediated oxidative stress and apoptosis in neuronal cells	4
Gas chromatography-tandem mass spectrometric analysis of metaldehyde and its metabolite acetaldehyde in initial assessment of hemodialysis abatement of toxicity in live animals	4
Proteomic characteristics of PM2.5-induced differentially expressed proteins in k-ras-silenced HBE cells	4
Safety assessment of a novel water-soluble extract of Boswellia serrata gum resin: acute toxicity, 90-day sub-chronic toxicity, Ames’ bacterial reverse mutation, and in vivo micronucleus	4
Quercetin acts via the G3BP1/YWHAZ axis to inhibit glycolysis and proliferation in oral squamous cell carcinoma	4
Transcriptomic profiling reveals crizotinib-induced hepatotoxicity through ROS-mediated activation of the JNK/NLRP3 pathway	4
Metformin attenuates PM 2.5 -induced oxidative stress by inhibiting the AhR/CYP1A1 pathway in proximal renal tubular epithelial cells	4
Zebrafish larvae locomotion bioassay: application on nanofractionated Naja nigricollis venom	4
Lauric acid attenuates hepato-metabolic complications and molecular alterations in high-fat diet-induced nonalcoholic fatty liver disease in rats	4
IN VIVO , IN VITRO AND IN SILICO Toxicology Studies of Nanoplastics and Their Modeling	4
Pharmacological prophylaxis with pyridostigmine bromide against nerve agents adversely impact on airway function in an ex vivo rat precision-cut lung slice model	4
Quercetin induces ferroptosis by inactivating mTOR/S6KP70 pathway in oral squamous cell carcinoma	4
Non-monotonic effects of Bisphenol A Dimethacrylate on male mouse reproductive system and fertility leads to impaired conceptive performance	4
Sentinel role of military dogs in detecting genotoxic agents in the environment during military operations: a pilot study	4
Motor-evoked potentials after focal electrical stimulation predict drug-induced convulsion potentials in rats	4
Naturally-derived phenethyl isothiocyanate modulates apoptotic induction through regulation of the intrinsic cascade and resulting apoptosome formation in human malignant melanoma cells	4
Inhalation safety and tolerability of a novel fixed-dose combination of glycopyrronium–vilanterol powder in Wistar rats	4
Development of reliable quantitative structure–toxicity relationship models for toxicity prediction of benzene derivatives using semiempirical descriptors	4
Drug target genes and molecular mechanism investigation in isoflurane-induced anesthesia based on WGCNA and machine learning methods	4
An integrated in silico and in vivo approach to determine the effects of three commonly used surfactants sodium dodecyl sulphate, cetylpyridinium chloride and sodium laureth sulphate on	3
Statement of Retraction: Synergistic, cytotoxic and apoptotic activities of olmesartan with NF-κB inhibitor against HeLa human cell line	3
Impact of ethanol as a vehicle for water-insoluble pollutants in BEAS-2B cell toxicity assays	3
An ex vivo model to evaluate DNA damage by comet assay in breast-cancer tissue	3
Mitigative impact of bradykinin potentiating factor isolated from Androctonus amoreuxi scorpion venom and low doses of γ-irradiation on doxorubicin induced hepatotoxicity through ang II/AMPK cr	3
Ramelteon and mechanism of its restorative effect in an experimental lung disease model	3
Using machine learning to classify the immunosuppressive activity of per- and polyfluoroalkyl substances	3
Polystyrene microplastic particles induced hepatotoxic injury via pyroptosis, oxidative stress, and fibrotic changes in adult male albino rats; the therapeutic role of silymarin	3
Insights into mitochondrial creatine kinase: examining preventive role of creatine supplement in doxorubicin-induced cardiotoxicity	3
Silver nanoparticle toxicity in rainbow trout: insights into physiological and molecular responses	3
N-acetylcysteine ameliorates monocrotophos exposure-induced mitochondrial dysfunctions in rat liver	3
A QSAR study for predicting malformation in zebrafish embryo	3
Atrazine modifies markers of melanocyte maturation and apoptosis in primary skin cultures	3
Developmental exposure to the A6-pesticide causes changes in tyrosine hydroxylase gene expression, neurochemistry, and locomotors behavior in larval zebrafish	3
Optimization of long-term incubation of precision-cut kidney slices	3
Mirtazapine attenuated cadmium-induced neuronal intoxication by regulating Nrf2 and NF-κB/TLR4 signals	3
The effects of prenatal and lactational bisphenol A and/or di(2-ethylhexyl) phthalate exposure on female reproductive system	3
Fermented whey modulated AFB1 and OTA-induced hepatotoxicity and nephrotoxicity in vivo. A relative and absolute quantification about sex differences	3
Effects of benzoic acid synthesized from Cinnamomum cassia by green chemistry on valproic acid-induced neurotoxicity in zebrafish embryos	3
UR-144, synthetic cannabinoid receptor agonist, induced cardiomyoblast toxicity mechanism comprises cytoplasmic Ca2+and DAPK1 related autophagy and necrosis	3
Cardioprotective effect of allyl isothiocyanate in a rat model of doxorubicin acute toxicity	3
Oleanolic acid-based therapeutics ameliorate rotenone-induced motor and depressive behaviors in parkinsonian male mice via controlling neuroinflammation and activating Nrf2-BDNF-dopaminergic signaling	3
Undifferentiated versus retinoic acid-differentiated SH-SY5Y cells in investigation of markers of neural function in toxicological research	3
Correction	2
Serum α-SMA is a potential noninvasive biomarker of liver fibrosis	2
Mechanistic insights into the impact of WIN 55, 212-2, a synthetic cannabinoid, on adhesion molecules PECAM-1 and VE-cadherin in HeLa cells: implications on cancer processes	2
Mechanisms involved in the valproic acid-induced hepatotoxicity: a comprehensive review	2
Long non-coding RNA maternally expressed 3 (MEG3) regulates isoflurane-induced cognitive dysfunction by targeting miR-7-5p	2
Differential effects of OATP2B1 on statin accumulation and toxicity in a beta cell model	2
Evaluation and comparison of DNA alkylation and oxidative damage in e-cigarette and heated tobacco users	2
Ontogenetic development of metabolic and detoxification genes in Seriola rivoliana larvae	2
Network toxicology analysis reveals molecular mechanisms associated with noise exposure to multiple diseases	2
Acutely increased aquaporin-4 exhibits more potent protective effects in the cortex against single and repeated isoflurane-induced neurotoxicity in the developing rat brain	2
Modification of the hemodynamic and molecular features of phosphine, a potent mitochondrial toxicant in the heart, by cannabidiol	2
Leveraging new approach methodologies: ecotoxicological modelling of endocrine disrupting chemicals to Danio rerio through machine learning and toxicity studies	2
Propofol alleviates traumatic brain injury through regulating Th17/Treg balance by activation of the AMPK/SIRT1 pathway	2
A systematic review of preclinical studies on the taurine role during diabetic nephropathy: focused on anti-oxidative, anti-inflammation, and anti-apoptotic effects	2
Obesity aggravates neuroinflammatory and neurodegenerative effects of bisphenol A in female rats	2
Protective effect of indomethacin on vanadium-induced adrenocortical and testicular damages in rat	2
Combination of oxytetracycline and quinocetone synergistically induces hepatotoxicity via generation of reactive oxygen species and activation of mitochondrial pathway	2
Aristolochic acid I aggravates oxidative stress-mediated apoptosis by inhibiting APE1/Nrf2/HO-1 signaling	2
Bioinformatics analysis to identify endocrine-disrupting chemicals targeting key ESCC-related genes	2
Chitosan and solid lipid nanoparticles enhance the efficiency of alpha-lipoic acid against experimental neurotoxicity	2
Effect of iodinated contrast media on peripheral blood mononuclear cells in terms of cell viability, cell cycle and oxidative stress in an in vitro system	2
Disruptive multiple cell death pathways of bisphenol-A	2
Analysis of toxicity effects of delta-9-tetrahydrocannabinol on isolated rat heart mitochondria	2
Mass spectrometric methods for evaluation of voriconazole avian pharmacokinetics and the inhibition of its cytochrome P450-induced metabolism	2

Isoflurane pretreatment protects against myocardial ischemia/reperfusion injury via mediating lncRNA CASC15/miR-542-3p axis	2
Analytical and toxicological aspects of dithiocarbamates: an overview of the last 10 years	2
Exploring the impact of ambient air PM 2.5 on multiple sclerosis: an experimental dive into neuroinflammation	2
Identification of miRNAs and target genes associated with lymph node metastasis in cervical cancer using bioinformatics analysis	2
Application and prospect of organoids in tobacco product safety and risk evaluation	2
Design of a microfluidic lung chip and its application in assessing the toxicity of formaldehyde	2
New mechanistic approach of TiCN film-coated NiTi substrate toxicity: impairment in mitochondrial electron transfer in diabetic rat tooth gum cells	2
Neodymium nitrate promotes the apoptosis of mouse liver cells via Bcl2l1/Caspase 3 pathway	2
Utilizing network pharmacological analysis to investigate the key targets and mechanisms of kaempferol against oxaliplatin-induced neurotoxicity	2
Leflunomide-induced cardiac injury in adult male mice and bioinformatic approach identifying Nrf2/NF-κb signaling interplay	2
From historical drugs to present perils: UHPLC-QqQ-MS/MS determination of methaqualone and its designer analogs (NPS) with comprehensive fragmentation pathways study (QTOF)	2
Neuroprotective effect of marrubiin against MPTP-induced experimental Parkinson’s disease in male wistar rats	2