Toxicology Mechanisms and Methods

Papers
(The TQCC of Toxicology Mechanisms and Methods is 5. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-08-01 to 2025-08-01.)
ArticleCitations
An improved method for toxicological profiling of chemical substances151
PARP-1 inhibits DNMT1-mediated promoter methylation and promotes linc01132 expression in benzene-exposed workers and hydroquinone-induced malignant transformed cells37
Effects of nano-titanium dioxide on calcium homeostasisin vivoandin vitro: a systematic review and meta-analysis34
Evaluation of the protective effects of curcumin-rich turmeric ( Curcuma longa ) extract against isotretinoin-induced liver damage in rats31
Effects of acute carbon monoxide poisoning on liver damage and comparisons of related oxygen therapies in a rat model30
Potential of paracetamol for reproductive disruption: molecular interaction, dynamics, and MM-PBSA based in-silico assessment29
Human stromal cell-based protocol to generate astrocytes: a straightforward in vitro predictive strategy in neurotoxicology29
Neuroprotective effect of taxifolin against aluminum chloride-induced dementia and pathological alterations in the brain of rats: possible involvement of toll-like receptor 425
Salinomycin induces cell cycle arrest and apoptosis and modulates hepatic cytochrome P450 mRNA expression in HepG2/C3a cells25
Development a high-throughput zebrafish embryo acute toxicity testing method based on OECD TG 23622
Cadmium-induced pancreatic toxicity in rats: comparing vitamin C and Nigella sativa as protective agents: a histomorphometric and ultrastructural study22
Chronological activation of the NLRP3 inflammasome/pyroptosis pathway in the progression from metabolic dysfunction-associated fatty liver disease to hepatocellular carcinoma22
Flow-through imaging and automated analysis of oil-exposed early stage Atlantic cod ( Gadus morhua )20
Evaluating the protective role of Deglycyrrhizinated licorice root supplement on bleomycin induced pulmonary oxidative damage19
Neuroprotective effect ofBryophyllum pinnatumflavonoids against aluminum chloride-induced neurotoxicity in rats16
Maternal long-term inhalation exposure to perchloroethylene and prenatal teratogenicity: morphometric, hormonal, and histological study16
A simple protocol for estimating the acute toxicity of unresolved polar compounds from field-weathered oils15
Establishing a link between the chemical composition and biological activities of Gladiolus italicus Mill. from the Turkish flora utilizing in vitro 15
Implications of plastic-derived endocrine disruptors on human health15
The protective effect of co-administration of platelet-rich plasma (PRP) and pentoxifylline (PTX) on cyclophosphamide-induced premature ovarian failure in mature and immature rats14
Alcohol-induced hormonal and metabolic alterations in plasma and erythrocytes—a gender-based study14
Correction14
Mechanistic paradigms of immunotoxicity, triggered by nanoparticles – a review14
Dexamethasone as an anti-cancer or hepatotoxic14
Correction14
Toxicological impact of copper nanoparticles on rainbow trout: hematological, biochemical, antioxidant, and histopathological responses with oxidative gene expression13
Toxicoproteomics reveals an effect of clozapine on autophagy in human liver spheroids13
Decoding the possible mechanism of action of Paeoniflorigenone in combating Aflatoxin B1-induced liver cancer: an investigation using network pharmacology and bioinformatics analysis12
Evaluation of cytotoxicity, analysis of metals and cumulative risk assessment in microalgae12
Precision-cut liver slices as a model for assess hepatic cellular response of chitosan–glutathione nanoparticles on cultures treated with zilpaterol and clenbuterol12
Leveraging AlphaFold models to predict androgenic effects of endocrine-disrupting chemicals through zebrafish androgen receptor analysis12
Time-course cross-species transcriptomics reveals conserved hepatotoxicity pathways induced by repeated administration of cyclosporine A12
Mitochondrial toxic prediction of marine alga toxins using a predictive model based on feature coupling and ensemble learning algorithms12
Topiramate affords neuroprotection in diabetic neuropathy model via downregulating spinal GFAP/inflammatory burden and improving neurofilament production11
Bioinformatics analysis of differentially expressed genes related to ischemia and hypoxia in spinal cord injury and construction of miRNA-mRNA or mRNA-transcription factor interaction network11
Should ebselen be considered for the treatment of mercury intoxication? A minireview11
The stability of cyanide in human biological samples. A systematic review, meta-analysis and determination of cyanide (GC-QqQ-MS/MS) in an authentic casework 7 years after fatal intoxication11
PM 2.5 -induced DNA oxidative stress in A549 cells and regulating mechanisms by GST DNA methylation and Keap1/Nrf2 pathway11
Diacerein counteracts amiodarone‑induced hepatotoxicity in rats via targeting TLR4/NF-kB/NLRP3 pathways10
Third party product certification for drinking water health effects10
Molecular signatures associated with diuron exposure on rat urothelial mitochondria9
Investigation of some metal levels in people using electronic cigarettes and IQOS9
Nano and microplastics: unveiling their profound impact on endocrine health9
Aloe-emodin upregulates DUSP1 to alleviate aristolochic acid-induced renal tubular epithelial cell damage9
Concerted hepatoprotective effect of bradykinin potentiating factor and low dose of γ- radiation on Naja haje envenomed rats via Bax/Bcl2 pathway9
Therapeutic and prophylactic role of vitamin D and curcumin in acetic acid-induced acute ulcerative colitis model8
Behavioral Pharmacology and Toxicology of Dimethyl Sulfoxide in Artemia nauplii : Vehicle or positive control?8
Use of TLM derived models to estimate toxicity of weathered MC252 oil based on conventional chemical data and the potential impact of unresolved polar components8
5-Hydroxymethylfurfural causes reproductive toxicity in male mice by increasing oxidative stress and apoptosis through the Nrf2/HO-1 signaling pathway8
PM2.5 mediates mouse testis Sertoli TM4 cell damage by reducing cellular NAD +8
Studies on pharmacokinetic properties and intestinal absorption mechanism of sanguinarine chloride: in vivo and in situ8
Evaluation of acute, subacute, subchronic, reproductive, and genotoxicity of a standardized extract from the bark of Oroxylum indicum8
In silico aquatic toxicity prediction of chemicals toward Daphnia magna and fathead minnow using Monte Carlo approaches8
Effects of pumpkin and fermented whey on fecal microbiota profile against AFB1 and OTA exposure in Wistar rats8
Significant shifts in preclinical and clinical neurotoxicology: a review and commentary8
Implications of Withaferin A for the metastatic potential and drug resistance in hepatocellular carcinoma cells via Nrf2-mediated EMT and ferroptosis8
Does the accounting of the local symmetry fragments in quasi-SMILES improve the predictive potential of the QSAR models of toxicity toward tadpoles?8
Quantitative structure–toxicity relationship models for predication of toxicity of ionic liquids toward leukemia rat cell line IPC-81 based on index of ideality of correlation8
Evidence of binding between diethylstilbestrol (DES) and the goldfish ( Carassius auratus ) membrane progesterone receptor α7
Development of mass spectrometric methods for determination of desoxycorticosterone pivalate and its esterase product in canine serum7
Defective mitophagy and induction of apoptosis by the depleted levels of PINK1 and Parkin in Pb and β-amyloid peptide induced toxicity7
Clinical and safety outcomes associated with aristolochic acid exposure: a systematic review and meta-analysis7
Effects of organophosphates on precision-cut kidney slices7
An in silico toxicogenomic approach in constructing the aflatoxin B1-mediated regulatory network of hub genes in hepatocellular carcinoma7
Effects of imidacloprid on viability and increase of reactive oxygen and nitrogen species in HepG2 cell line7
Ellagic acid inhibits proinflammatory intermediary manufacture by suppressing NF-κB/Akt, VEGF and activating Nrf-2/Caspase-3 signaling pathways in rat testicular damage: a new way for testicular damag7
Differences in metabolite genotoxicity test results of rat liver S9 microsomes treated with various microsomal enzyme inducers7
Application of three-dimensional Raman imaging to determination of the relationship between cellular localization of diesel exhaust particles and the toxicity7
Exposure to di (2-ethylhexyl) phthalate causes locomotor increase and anxiety-like behavior via induction of oxidative stress in brain6
Deferoxamine ameliorated Al(mal)3-induced neuronal ferroptosis in adult rats by chelating brain iron to attenuate oxidative damage6
Antioxidant and antihyperlipidemic activities of catechol derivatives and biflavonoid isolated from Semecarpus anacardium seeds6
The regulatory effects of pomiferin dietary on nickel-induced hepatic injury in Sprague–Dawley rats; action mechanisms and signaling pathways6
Modulating oxidative stress, apoptosis, and mitochondrial dysfunctions on cardiotoxicity induced by aluminum phosphide pesticide using resveratrol6
The flavonoid hyperoside attenuates the toxic effect of cisplatin on the human ovarian granulosa cells: in vitro model study6
Enhanced kidney damage induced by increasing nonylphenol doses: impact on autophagy-related proteins and proinflammatory cytokines in rats6
Exposure to phagolysosomal simulated fluid altered the cytotoxicity of PET micro(nano)plastics to human lung epithelial cells6
Chronic oral exposure of aluminum chloride in rat modulates molecular and functional neurotoxic markers relevant to Alzheimer’s disease6
Perinatal exposure to the immune-suppressant di-n-octyltin dichloride affects brain development in rats6
Nano-CuO causes cell damage through activation of dose-dependent autophagy and mitochondrial lncCyt b-AS/ND5-AS/ND6-AS in SH-SY5Y cells6
Integrated transcriptomic and proteomic analyses reveal the effects of chronic benzene exposure on the central nervous system in mice6
Comparison of carcinogenic potential of alternative tobacco products. A systematic review5
Protective effect of Pulsatilla saponin A on acute myocardial infarction via miR-24-3p/p165
Royal jelly abrogates flouride-induced oxidative damage in rat heart tissue by activating of the nrf-2/NF-κB and bcl-2/bax pathway5
Inhalation safety and tolerability of a novel fixed-dose combination of glycopyrronium–vilanterol powder in Wistar rats5
Sentinel role of military dogs in detecting genotoxic agents in the environment during military operations: a pilot study5
Enhanced anti-cancer efficacy of Sorafenib and Pioglitazone via VEGF inhibition in DMBA-induced breast cancer model5
Metformin attenuates PM 2.5 -induced oxidative stress by inhibiting the AhR/CYP1A1 pathway in proximal renal tubular epithelial cells5
Protective effects of polysaccharide extracted from green alga Chaetomorpha linum against zinc and copper-induced testicular toxicity in male mice5
Agomelatine ameliorates doxorubicin-induced cortical and hippocampal brain injury via inhibition of TNF-alpha/NF-kB pathway5
Transcriptomic profiling reveals crizotinib-induced hepatotoxicity through ROS-mediated activation of the JNK/NLRP3 pathway5
Development of a standard operating procedure for the DCFH2-DA acellular assessment of reactive oxygen species produced by nanomaterials5
Comparison of different QT correction methods for nonclinical safety assessment in ketamine-anesthetized Indian rhesus monkeys (Macaca mulatta)5
Evaluation of possible cytotoxic, genotoxic and epigenotoxic effects of titanium dioxide nanoparticles and possible protective effect of melatonin5
Safety assessment of high fructose corn syrup and fructose used as sweeteners in foods5
Molecular heterogeneity in pediatric sepsis: identification of oxidative stress-related subtypes and diagnostic biomarkers through integrated bioinformatics analysis5
Lauric acid attenuates hepato-metabolic complications and molecular alterations in high-fat diet-induced nonalcoholic fatty liver disease in rats5
Integrating network pharmacology and in vitro model to investigate hippocampal neurotoxicity induced by atrazine5
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