OOIR: Observatory of International Research

Papers

(The TQCC of Toxicology Mechanisms and Methods is 5. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-04-01 to 2025-04-01.)

Article	Citations
Potential of paracetamol for reproductive disruption: molecular interaction, dynamics, and MM-PBSA based in-silico assessment	124
Integrated transcriptomic and proteomic analyses reveal the effects of chronic benzene exposure on the central nervous system in mice	36
Silica-induced ROS in alveolar macrophages and its role on the formation of pulmonary fibrosis via polarizing macrophages into M2 phenotype: a review	35
Do professional painters comprise a high risk group for genotoxicity? A systematic review	26
The effect of simvastatin induced neurotoxicity on mitochondrial function in human neuronal cells	26
The regulatory effects of pomiferin dietary on nickel-induced hepatic injury in Sprague–Dawley rats; action mechanisms and signaling pathways	23
Statement of Retraction: Synergistic, cytotoxic and apoptotic activities of olmesartan with NF-κB inhibitor against HeLa human cell line	22
Clinical and safety outcomes associated with aristolochic acid exposure: a systematic review and meta-analysis	21
Effects of imidacloprid on viability and increase of reactive oxygen and nitrogen species in HepG2 cell line	20
Defective mitophagy and induction of apoptosis by the depleted levels of PINK1 and Parkin in Pb and β-amyloid peptide induced toxicity	20
Effects of nano-titanium dioxide on calcium homeostasisin vivoandin vitro: a systematic review and meta-analysis	19
Modulating oxidative stress, apoptosis, and mitochondrial dysfunctions on cardiotoxicity induced by aluminum phosphide pesticide using resveratrol	18
Fifteen day repeat air: liquid Interface air-only exposures can cause respiratory epithelium injury in MucilAir ^™ nasal respiratory epithelial cells that parallels c	17
Diuron and its metabolites induce mitochondrial dysfunction-mediated cytotoxicity in urothelial cells	16
Implications for herbal polypharmacy: coumarin-induced hepatotoxicity increased through common herbal phytochemicals astragaloside IV and atractylenolide I	16
The fluorosis conundrum: bridging the gap between science and public health	15
Comparing automated cell imaging with conventional methods of measuring cell proliferation and viability	15
Application of three-dimensional Raman imaging to determination of the relationship between cellular localization of diesel exhaust particles and the toxicity	14
Silver nanoparticle-induced cell damage via impaired mtROS-JNK/MnSOD signaling pathway	14
Grape seed extract proanthocyanidin antagonizes aristolochic acid I-induced liver injury in rats by activating PI3K-AKT pathway	13
PARP-1 inhibits DNMT1-mediated promoter methylation and promotes linc01132 expression in benzene-exposed workers and hydroquinone-induced malignant transformed cells	13
The effect of GSK-3β in arsenic-induced apoptosis of malignant tumor cells: a systematic review and meta-analysis	13
Analysis of cytotoxicity and genotoxicity in a short-term dependent manner induced by a new titanium dioxide nanoparticle in murine fibroblast cells	12
Ellagic acid inhibits proinflammatory intermediary manufacture by suppressing NF-κB/Akt, VEGF and activating Nrf-2/Caspase-3 signaling pathways in rat testicular damage: a new way for testicular damag	12
An integrated in silico and in vivo approach to determine the effects of three commonly used surfactants sodium dodecyl sulphate, cetylpyridinium chloride and sodium laureth sulphate on	12

Chronic oral exposure of aluminum chloride in rat modulates molecular and functional neurotoxic markers relevant to Alzheimer’s disease	11
Evidence of binding between diethylstilbestrol (DES) and the goldfish ( Carassius auratus ) membrane progesterone receptor α	11
An in silico toxicogenomic approach in constructing the aflatoxin B1-mediated regulatory network of hub genes in hepatocellular carcinoma	11
An improved method for toxicological profiling of chemical substances	11
Spatial memory impairment is associated with decreased dopamine-β-hydroxylase activity in the brains of rats exposed to manganese chloride	10
Evaluation of doxorubicin-induced early multi-organ toxicity in male CD1 mice by biodistribution of¹⁸F-FDG and⁶⁷Ga-citrate. Pilot study	10
Developmental exposure to the A6-pesticide causes changes in tyrosine hydroxylase gene expression, neurochemistry, and locomotors behavior in larval zebrafish	10
Balancing renal Ang-II/Ang-(1–7) by xanthenone; an ACE2 activator; contributes to the attenuation of Ang-II/p38 MAPK/NF-κB p65 and Bax/caspase-3 pathways in amphotericin B-induced nephrotoxicity in ra	10
Pymetrozine induced remarkable hemato-biochemical modifications and genotoxicity in vital organs of bighead carp ( Aristichthys nobilis )	10
Optimization of long-term incubation of precision-cut kidney slices	9
Development of chlorine-induced lung injury in the anesthetized, spontaneously breathing pig	9
Antioxidant thymoquinone and eugenol alleviate TiO₂nanoparticle-induced toxicity in human blood cellsin vitro	9
Advancements in heavy metal detection using microneedle array technology	9
Using machine learning to classify the immunosuppressive activity of per- and polyfluoroalkyl substances	9
Schisandrin A alleviates mycophenolic acid-induced intestinal toxicity by regulating cell apoptosis and oxidative damage	9
The neuroprotective effect of mesenchymal stem cells in colistin-induced neurotoxicity	8
Use of clinical chemistry health outcomes and PFAS chain length to predict 28-day rodent oral toxicity	8
The effects of prenatal and lactational bisphenol A and/or di(2-ethylhexyl) phthalate exposure on female reproductive system	8
Salinomycin induces cell cycle arrest and apoptosis and modulates hepatic cytochrome P450 mRNA expression in HepG2/C3a cells	8
Exposure to phagolysosomal simulated fluid altered the cytotoxicity of PET micro(nano)plastics to human lung epithelial cells	8
Differences in metabolite genotoxicity test results of rat liver S9 microsomes treated with various microsomal enzyme inducers	8
Effects of acute carbon monoxide poisoning on liver damage and comparisons of related oxygen therapies in a rat model	8
Effects of organophosphates on precision-cut kidney slices	8
Silver nanoparticle toxicity in rainbow trout: insights into physiological and molecular responses	8
Exposure to di (2-ethylhexyl) phthalate causes locomotor increase and anxiety-like behavior via induction of oxidative stress in brain	7
Human stromal cell-based protocol to generate astrocytes: a straightforward in vitro predictive strategy in neurotoxicology	7
Neuroprotective effect of taxifolin against aluminum chloride-induced dementia and pathological alterations in the brain of rats: possible involvement of toll-like receptor 4	7
The investigation of the toxicity of organophosphorus flame retardants (OPFRs) by using in silico toxicity prediction platform ProTox- 3.0	7
Evaluation of the protective effects of curcumin-rich turmeric ( Curcuma longa ) extract against isotretinoin-induced liver damage in rats	7
Oleanolic acid-based therapeutics ameliorate rotenone-induced motor and depressive behaviors in parkinsonian male mice via controlling neuroinflammation and activating Nrf2-BDNF-dopaminergic signaling	7
Mirtazapine attenuated cadmium-induced neuronal intoxication by regulating Nrf2 and NF-κB/TLR4 signals	7
Neuroprotective potential of trimetazidine against tramadol-induced neurotoxicity: role of PI3K/Akt/mTOR signaling pathways	7
Eucalyptol regulates Nrf2 and NF-kB signaling and alleviates gentamicin-induced kidney injury in rats by downregulating oxidative stress, oxidative DNA damage, inflammation, and apoptosis	6
Undifferentiated versus retinoic acid-differentiated SH-SY5Y cells in investigation of markers of neural function in toxicological research	6
The ameliorative effect of Lactobacillus paracasei BEJ01 against FB1 induced spermatogenesis disturbance, testicular oxidative stress and histopathological damage	6
Toxicological aspect of bioinsecticide pyrethrum extract and expressions of apoptotic gene levels in human hepotacellular carcinoma HepG2 cells	6
A critical insight into the physicochemical stability of macular carotenoids with respect to their industrial production, safety profile, targeted tissue delivery, and bioavailability	6
Neuroprotective effect ofBryophyllum pinnatumflavonoids against aluminum chloride-induced neurotoxicity in rats	6
Evaluation of possible cytotoxic, genotoxic and epigenotoxic effects of titanium dioxide nanoparticles and possible protective effect of melatonin	6
Unveiling the impact of estrogen exposure on ovarian cancer: a comprehensive risk model and immune landscape analysis	6
Evaluating the protective role of Deglycyrrhizinated licorice root supplement on bleomycin induced pulmonary oxidative damage	6
Prophylactic effect of probiotics fortified withAloe verapulp nanoemulsion against ethanol-induced gastric ulcer	6
Study of the acute and repeated dose 28-day oral toxicity in mice treated with PT-31, a molecule with a potential antipsychotic profile	6
Assessment of genotoxic damage induced by exposure to binary mixtures of polycyclic aromatic hydrocarbons and three heavy metals in male mice	6
HepG2 spheroids cultured in alginate microcapsules as a model for exploring mitochondrial and glycolytic metabolism using the Seahorse XFe24 Analyzer	6
Maternal long-term inhalation exposure to perchloroethylene and prenatal teratogenicity: morphometric, hormonal, and histological study	6
Mechanistic paradigms of immunotoxicity, triggered by nanoparticles – a review	6
Cleistanthin A causes peripheral vasoconstriction and myocardial depression in isolated tissue preparations	5
Exosomes derived from bone marrow mesenchymal stem cells reverse epithelial-mesenchymal transition potentially via attenuating Wnt/β-catenin signaling to alleviate silica-induced pulmonary fibrosis	5
Down-regulation of miR-204-5p ameliorates sevoflurane-induced brain injury in neonatal rats through targeting VCAM1	5

The absence of genotoxicity of a mixture of aloin A and B and a commercial aloe gel beverage	5
Nano-CuO causes cell damage through activation of dose-dependent autophagy and mitochondrial lncCyt b-AS/ND5-AS/ND6-AS in SH-SY5Y cells	5
Neuroprotective effect of miR-212-5p on isoflurane-induced cognitive dysfunction by inhibiting neuroinflammation	5
Evaluation of Calu-3 cell lines as anin vitromodel to study the inhalation toxicity of flavoring extracts	5
A novel multi-omics data analysis of dose-dependent and temporal changes in regulatory pathways due to chemical perturbation: a case study on caffeine	5
Antihyperlipidemic effect of tyrosol, a phenolic compound in streptozotocin-induced diabetic rats	5
Attenuation of experimentally induced atopic dermatitis in mice by sulforaphane: effect on inflammation and apoptosis	5
Disruptive multiple cell death pathways of bisphenol-A	5
Hematotoxic, oxidative and genotoxic damage in rainbow trout (Oncorhynchus mykiss) after exposure to 3-benzoylpyridine	5
Development of a standard operating procedure for the DCFH₂-DA acellular assessment of reactive oxygen species produced by nanomaterials	5
Leflunomide-induced cardiac injury in adult male mice and bioinformatic approach identifying Nrf2/NF-κb signaling interplay	5
Acutely increased aquaporin-4 exhibits more potent protective effects in the cortex against single and repeated isoflurane-induced neurotoxicity in the developing rat brain	5
The role of tetrahydroxyquinone solubility on apoptosis induction in human colorectal cells	5