Cancer Biology & Therapy

Article	Citations
Molecular profiles of different PD-L1 expression in patients with esophageal squamous cell carcinoma	98
Epigenetic silencing L3MBTL4 sensitizes esophageal cancer to DNA-PKcs inhibitor	85
Correction	71
A novel biochip-based liquid biopsy for extracellular vesicle RNA detection in prostate cancer	66
Advances in natural killer cell immunotherapy for hematologic malignancies	64
A comparison of cell death pathways in three different kinds of human lung cancer cell lines following hematoporphyrin derivative-mediated photodynamic therapy	57
Impact of leucine-rich diet on placenta's proteomic and metabolomic profiles of pregnant tumor-bearing rats	50
miRNA-660-3p inhibits malignancy in glioblastoma via negative regulation of APOC1-TGFβ2 signaling pathway	49
Evaluating massage therapy for radiation-induced fibrosis in rats: preliminary findings and palpation results	47
Suppression of LncRNA AC008406.3 sensitizes breast cancer cells to docetaxel via triggering cuproptosis	46
Effective treatment of human breast tumors by chimeric CCL2 and CCL8 diphtheria toxin cytotoxic peptides	45
DDX24 regulates the chemosensitivity of hepatocellular carcinoma to sorafenib via mediating the expression of SNORA18	43
Clinical application of molecular residual disease detection by circulation tumor DNA in solid cancers and a comparison of technologies: review article	39
Dual role of CXCL10 in cancer progression: implications for immunotherapy and targeted treatment‎	39
Tripartite motif-containing protein 50 suppresses triple-negative breast cancer progression by regulating the epithelial–mesenchymal transition	38
Immunotherapy resistance in solid tumors: mechanisms and potential solutions	33
Advancements in exosome-based cancer diagnosis: from chipsets to nano vaccine	32
The MYBL2-GTSE1 axis promotes laryngeal squamous cell carcinoma progression by regulating PI3K/AKT-dependent glycolytic reprogramming	31
CPT1A mediates the succinylation of SP5 which activates transcription of PDPK1 to promote the viability and glycolysis of prostate cancer cells	31
GdX inhibits the occurrence and progression of breast cancer by negatively modulating the activity of STAT3	30
SATB1 mediated tumor colonization and β-catenin nuclear localization are associated with colorectal cancer progression	29
Protein lactylation: molecular mechanisms underlying lactate-driven tumorigenesis and cancer progression	29
MiR-128-1-5p inhibits cell proliferation and induces cell apoptosis via targeting PRKCQ in colorectal cancer	27
Aldolase A promotes cervical cancer cell radioresistance by regulating the glycolysis and DNA damage after irradiation	26
Linoleic acid exhibits anti-proliferative and anti-invasive activities in endometrial cancer cells and a transgenic model of endometrial cancer	26

Silencing ZIC5 suppresses glycolysis and promotes disulfidptosis in lung adenocarcinoma cells	26
Parthenolide inhibits the progression of intrahepatic cholangiocarcinoma by promoting ferroptosis through inhibiting UBD	25
Antibody dependent cell-mediated cytotoxicity selection pressure induces diverse mechanisms of resistance	25
Mutant PIK3CA as a negative predictive biomarker for treatment with a highly selective PIM1 inhibitor in human colon cancer	25
Nucleo-cytoplasmic shuttling of 14-3-3 epsilon carrying hnRNP C promotes autophagy	25
Evaluating carboplatin and PARP inhibitor combination efficacy using high-grade serous carcinoma spheroids and organoids	24
LINC01060 knockdown inhibits osteosarcoma cell malignant behaviors in vitro and tumor growth and metastasis in vivo through the PI3K/Akt s	24
Isolated pulmonary metastases in pancreatic ductal adenocarcinoma: a review of current evidence	23
USP7 overexpression prevents the progression of clear cell renal cell carcinoma by enhancing pyroptosis via TRIP12 deubiquitination	23
Bibliometric analysis of autophagy in the diagnosis and treatment of osteosarcoma: a bibliometric analysis (2007–2023)	22
Liu-Shen-Wan inhibits PI3K/Akt and TRPV1 signaling alleviating bone cancer pain in rats	22
NRSN2 promotes the malignant behavior of HPV-transfected laryngeal carcinoma cells through AMPK/ULK1 pathway mediated autophagy activation	22
Navigating precision: the crucial role of next-generation sequencing recurrence risk assessment in tailoring adjuvant therapy for hormone receptor-positive, human epidermal growth factor Receptor2-neg	21
PCBP1 regulates LIFR through FAM3C to maintain breast cancer stem cell self-renewal and invasiveness	21
Long-term effects of neoadjuvant chemotherapy in variant histology locally advanced colon cancer: a propensity score-matched analysis	21
CDH2 and CDH13 as potential prognostic and therapeutic targets for adrenocortical carcinoma	21
NDUFA4L2 reduces mitochondrial respiration resulting in defective lysosomal trafficking in clear cell renal cell carcinoma	20
The impact of drug-eluting bead (vs. conventional) transarterial chemoembolization on hepatic fibrosis in treating intermediate or advanced hepatocellular carcinoma	20
Correction	19
Autophagic degradation of CDK4 is responsible for G0/G1 cell cycle arrest in NVP-BEZ235-treated neuroblastoma	19
A positive feedback loop of SRSF9/USP22/ZEB1 promotes the progression of ovarian cancer	19
Lenvatinib potentiates the antitumor efficacy of combined radiotherapy and PD-L1 blockade in lung adenocarcinoma	18
Robust prediction of glioma prognosis by hypoxia-induced ferroptosis genes: VEGFA-XBP1 co-expression for salvage therapy	18
Downregulation of the lncRNA PGM5P4-AS1 predicts poor prognosis and drives breast cancer progression through miR-3664-5p/KLF9	18
Neoplastic CD3⁺ B cells remodel the DLBCL tumor microenvironment via single-cell and spatial transcriptomics	17
Leveraging the bacteria for enhanced cancer immunotherapy: from a perspective of synthetic biology	17
The critical role of tumor microbiome in cancer immunotherapy	17
Highly enriched exosomal lncRNA OIP5-AS1 regulates gastrointestinal stromal tumor (GIST) resistance to sunitinib through miR-145 and SOX9	16
SOX2 inhibits LLGL2 polarity protein in esophageal squamous cell carcinoma via miRNA-142-3p	16
HSF1 is involved in immunotherapeutic response through regulating APOJ/STAT3-mediated PD-L1 expression in hepatocellular carcinoma	16
Loss of ACSL1 fuels ferroptosis resistance in clear cell renal carcinoma	16
High tumor amplification burden is associated with TP53 mutations in the pan-cancer setting	15
Potential therapeutic GSK-3β inhibitor 9-ING-41 is active in combination with venetoclax in double-hit lymphoma (DHL)	15
Flotillin-1 enhances radioresistance through reducing radiation-induced DNA damage and promoting immune escape via STING signaling pathway in non-small cell lung cancer	15
CDK2 inhibition disorders centrosome stoichiometry and alters cellular outcomes in aneuploid cancer cells	15
CD8α Structural Domains Enhance GUCY2C CAR-T Cell Efficacy	15
The anticancer mechanisms of Toxoplasma gondii rhoptry protein 16 on lung adenocarcinoma cells	14
PI3Kγ inhibition drives M1 macrophage differentiation and synergizes with PD-L1 blockade to improve survival in poorly immunogenic head and neck squamous cell carcinoma	14
Acquired resistance to crizotinib in novel CDK14-ALK and CLTC-ALK fusions of ALK-positive large B-cell lymphoma identified by next-generation sequencing	14
Nuclear translocation of Cx43 promotes to CRC progression and associates with β-catenin accumulation	13
WYC-209 inhibited GC malignant progression by down-regulating WNT4 through RARα	13
Bis-(di-4-phenyl-benzylaminethiocarbonyl)disulfide sensitizes ABCC2/ALDH3A1 overexpressing NSCLC cells to cisplatin	13
DLAT promotes triple-negative breast cancer progression via YAP1 activation	13
Correction	13
MiR-378a-5p exerts a radiosensitizing effect on CRC through LRP8/β-catenin axis	13
Lenvatinib promotes hepatocellular carcinoma pyroptosis by regulating GSDME palmitoylation	13
Prognostic value of pretreatment procalcitonin and neutrophil–lymphocyte ratio in extensive-stage small-cell lung cancer	13
CX43 down-regulation promotes cell aggressiveness and 5-fluorouracil-resistance by attenuating cell stiffness in colorectal carcinoma	12
Agent-based modeling in cancer biomedicine: applications and tools for calibration and validation	12
Targeting mitochondrial tyrosyl-tRNA synthetase YARS2 suppresses colorectal cancer progression	12

β-amino acid substitution in the SIINFEKL antigen alters immunological recognition	12
Effect of extracellular vesicle ZNF280B derived from lung cancer stem cells on lung cancer progression	12
Fusobacterium nucleatum in tumors: from tumorigenesis to tumor metastasis and tumor resistance	12
CircSETD2 inhibits YAP1 by interaction with HuR during breast cancer progression	12
Correction	11
Repression of the SUMO-conjugating enzyme UBC9 is associated with lowered double minutes and reduced tumor progression	11
Angiotensin receptor blockade and stereotactic body radiation therapy for early stage lung cancer ARB & SBRT for early stage lung cancer	11
MGAT4EP promotes tumor progression and serves as a prognostic marker for breast cancer	11
Association between the IL1B-511 C>T polymorphism and the risk of hematologic malignancies: data from a meta-analysis	11
CircATP5C1 promotes triple-negative breast cancer progression by binding IGF2BP2 to modulate CSF-1 secretion	11
Identification of coilin in bone marrow as a potential neuroblastoma tumor progression marker transcriptionally regulated by MYCN	11
Establishment of a visualized mouse orthotopic xenograft model of nasopharyngeal carcinoma	11
The human microbiome and cancer: a diagnostic and therapeutic perspective	11
Salidroside inhibited the proliferation of gastric cancer cells through up-regulating tumor suppressor miR-1343-3p and down-regulating MAP3K6/MMP24 signal molecules	11
Roles of TRPM channels in glioma	11
MiR-18a-5p attenuates HER2-positive breast cancer development by regulating PI3K/AKT pathway	11
NCAPD2 promotes the progression of lung adenocarcinoma through an AKT/MDM2/E2F1 positive feedback loop	11
High-throughput screening identifies the activity of histone deacetylase inhibitors in patient-derived models of soft tissue sarcoma	10
M6A-mediated molecular patterns and tumor microenvironment infiltration characterization in nasopharyngeal carcinoma	10
Amino-truncated NOV expression and its correlation with clinicopathologic features, prognosis, metastasis, and chemoresistance in bladder cancer	10
Tumor-derived exosomal miR-1247-3p promotes angiogenesis in bladder cancer by targeting FOXO1	10
CD46 and CD59 inhibitors enhance complement-dependent cytotoxicity of anti-CD38 monoclonal antibodies daratumumab and isatuximab in multiple myeloma and other B-cell malignancy cells	10
First-line treatments for KRAS-mutant non-small cell lung cancer: current state and future perspectives	10
Clinical significance of WT1 in the evaluation of therapeutic effect and prognosis of non-M3 acute myeloid leukemia	10
Netrin-1 inducing antiapoptotic effect of acute myeloid leukemia cells in a concentration-dependent manner through the Unc-5 netrin receptor B-focal adhesion kinase axis	10
Integrating DOI in T classification improves the predictive performance of laryngeal cancer staging	10
ULK1's role in cancer progression and its emerging therapeutic potential	10
TP53AIP1 induce autophagy via the AKT/mTOR signaling pathway in the breast cancer cells	10
Influence of genetic polymorphisms in vascular endothelial-related genes on the clinical outcome of axitinib in patients with metastatic renal cell carcinoma	10
SLX1 silencing overcomes Olaparib resistance in metastatic castration-resistant prostate cancer by disrupting SLX4-mediated DNA repair complexes	10
Chaperonin containing TCP1 subunit 6A may activate Notch and Wnt pathways to facilitate the malignant behaviors and cancer stemness in oral squamous cell carcinoma	10
Knockdown of NDUFAF6 inhibits breast cancer progression via promoting mitophagy and apoptosis	10
IFN-γ downregulates miR-4319 to enhance NLRC5 and MHC-I expression in MHC-I-deficient breast cancer cells	9
Combination of metformin/efavirenz/fluoxetine exhibits profound anticancer activity via a cancer cell-specific ROS amplification	9
S-1-based concurrent chemoradiotherapy plus nimotuzumab in patients with locally advanced esophageal squamous cell carcinoma who failed neoadjuvant therapy: a real-world prospective study	9
Cyclophilin A: promising target in cancer therapy	9
Effects of combined radiotherapy with immune checkpoint blockade on immunological memory in luminal-like subtype murine bladder cancer model	9
VAMP8 suppresses the metastasis via DDX5/β-catenin signal pathway in osteosarcoma	9
RSK4 promotes the metastasis of clear cell renal cell carcinoma by activating RUNX1-mediated angiogenesis	9
Knockdown of LINC00511 enhances radiosensitivity of lung adenocarcinoma via regulating miR-497-5p/SMAD3	9
Obesity reduced survival with 5-fluorouracil and did not protect against chemotherapy-induced cachexia or immune cell cytotoxicity in mice	9
Neuroendocrine gene subsets are uniquely dysregulated in prostate adenocarcinoma	9
The antipsychotic drug pimozide promotes apoptosis through the RAF/ERK pathway and enhances autophagy in breast cancer cells	9
BRG1 promotes liver cancer cell proliferation and metastasis by enhancing mitochondrial function and ATP5A1 synthesis through TOMM40	9
Real-world efficacy of Bruton tyrosine kinase inhibitor based maintenance therapy in diffuse large B-cell lymphoma: a multicenter retrospective cohort study with external historical control	9
Extracellular vesicle-packaged miR-4253 secreted by cancer-associated fibroblasts facilitates cell proliferation in gastric cancer by inducing macrophage M2 polarization	9
USP44 promotes chemotherapeutic drug resistance of triple negative breast cancer through EZH2 protein stability	8
Fractionated radiotherapy initiated at the early stage of bone metastasis is effective to prolong survival in mouse model	8
The correlation between serum bone metabolism indexes and bone disease and survival in newly diagnosed multiple myeloma patients	8
The prognostic marker KRT81 is involved in suppressing CD8 + T cells and predicts immunotherapy response for triple-negative breast cancer	8
P4HA2 promotes tumor progression and is transcriptionally regulated by SP1 in colorectal cancer	8
Electrochemical biosensing in oncology: a review advancements and prospects for cancer diagnosis	8
Targeting CDK9 with selective inhibitors or degraders in tumor therapy: an overview of recent developments	8
Statement of Retraction: Didox (A Novel Ribonucleotide Reductase Inhibitor) Overcomes bc.l-2 Mediated Radiation Resistance in Prostate Cancer Cell Line PC-3	8
Drug repurposing based on differentially expressed genes suggests drug combinations with possible synergistic effects in treatment of lung adenocarcinoma	8
NSUN2 mediates SALL2 m5C methylation to inhibit ferroptosis and promote breast cancer progression	8
METTL14 decreases FTH1 mRNA stability via m6A methylation to promote sorafenib-induced ferroptosis of cervical cancer	8
NAALADL2-AS2 functions as a competing endogenous RNA to regulate apoptosis and drug resistance in DLBCL	8
Analysis of neuroglia and immune cells in the tumor microenvironment of breast cancer brain metastasis	8
Exosomal miR-122-5p for regulation of secretory functions of fibroblasts and promotion of breast cancer metastasis by targeting MKP-2: an experimental study	8
PSMD12 promotes the activation of the MEK-ERK pathway by upregulating KIF15 to promote the malignant progression of liver cancer	8
The polymeric fluoropyrimidine CF10 overcomes limitations of 5-FU in pancreatic ductal adenocarcinoma cells through increased replication stress	8
Role of glutaminyl-peptide cyclotransferase in breast cancer doxorubicin sensitivity	8
BMSC-derived exosomal lncRNA PTENP1 suppresses the malignant phenotypes of bladder cancer by upregulating SCARA5 expression	8
Deep and lasting response and acquired resistance to BRAFV600E targeting in a low-grade ovarian cancer patient	8
MiR-135a-3p inhibits the progression of prostate cancer by targeting TLR4	7
Ras interacting protein 1 facilitated proliferation and invasion of diffuse large B-cell lymphoma cells	7
hsa_circ_0020378 regulating miR-339-3p/COL1A1 promotes osteosarcoma progression	7
Lipopolysaccharide (LPS) stimulation of Pancreatic Ductal Adenocarcinoma (PDAC) and macrophages activates the NLRP3 inflammasome that influences the levels of pro-inflammatory cytokines in a co-cultur	7
RVd and CyBorD therapies remodel B-cell maturation signaling and alter immune and clonal architecture in multiple myeloma	7
Toll-like receptor 4 inhibition sensitizes non-small cell lung cancer to radiotherapy	7
NAT10 promotes the tumorigenesis and progression of laryngeal squamous cell carcinoma through ac4C modification of FOXM1 mRNA	7
Mutually exclusive teams-like patterns of gene regulation characterize phenotypic heterogeneity along the noradrenergic-mesenchymal axis in neuroblastoma	7
PLK4 inhibitor exhibits antitumor effect and synergizes sorafenib via arresting cell cycle and inactivating Wnt/β-catenin pathway in anaplastic thyroid cancer	7
RND1 inhibits epithelial-mesenchymal transition and temozolomide resistance of glioblastoma via AKT/GSK3-β pathway	7
Upregulation of TTYH3 by lncRNA LUCAT1 through interacting with ALYREF facilitates the metastasis in non-small cell lung cancer	7
EGR1/ LINC00839 /SOX5 axis modulates migration, invasion and Gemcitabine resistance of bladder cancer cells	7
Ruangan Lidan decoction inhibits the growth and metastasis of liver cancer by downregulating miR-9-5p and upregulating PDK4	7
The efficacy of induction chemotherapy or adjuvant chemotherapy added to concurrent chemoradiotherapy in T3-4N0-1M0 nasopharyngeal carcinoma: a propensity score-matched analysis	7
NVP-2, in combination with Orlistat, represents a promising therapeutic strategy for acute myeloid leukemia	6

Inhibition of STAT3-mediated glycolysis by bruceine D suppresses non-small-cell lung cancer progression in vitro and in vivo	6
Caspase 3-specific cleavage of ubiquitin-specific peptidase 48 enhances drug-induced apoptosis in AML	6
UCHL5 suppresses thyroid carcinoma progression via ZRANB1 stabilization and ferroptosis regulation	6
MOICS, a novel classier deciphering immune heterogeneity and aid precise management of clear cell renal cell carcinoma at multiomics level	6
KLF4 targets RAB26 and decreases 5-FU resistance through inhibiting autophagy in colon cancer	6
POLE2 silencing inhibits the progression of colorectal carcinoma cells via wnt signaling axis	6
Targeting the IKZF1/BCL-2 axis as a novel therapeutic strategy for treating acute T-cell lymphoblastic leukemia	6
Sinapine thiocyanate exhibited anti-colorectal cancer effects by inhibiting KRT6A/S100A2 axis	6
Molecular features, biological behaviors and clinical implications of m 5 C RNA methylation modification regulators in gastrointestinal cancers	6
The predictors of lymphopenia and its effects on survival in locally advanced esophageal squamous cell carcinoma	6
Correction	6
PINCH-1 promotes tumor growth and metastasis by enhancing DRP1-mediated mitochondrial fission in head and neck squamous cell carcinoma	6
N6-methyladenosine-regulated ADIRF impairs lung adenocarcinoma metastasis and serves as a potential prognostic biomarker	6
A study on metabolic characteristics and metabolic markers of gastrointestinal tumors	6
Patient-derived organoids (PDOs) as a promising platform for personalized treatment of colorectal cancer: current applications and future challenges	6
Assessing progesterone receptor modulation in glioblastoma: from in vitro and animal model to a human pilot protocol	6
STEAP2 promotes osteosarcoma progression by inducing epithelial–mesenchymal transition via the PI3K/AKT/mTOR signaling pathway and is regulated by EFEMP2	6
PCK2 promotes invasion and epithelial-to-mesenchymal transition in triple-negative breast cancer by promoting TGF-β/SMAD3 signaling through inhibiting TRIM67-mediated SMAD3 ubiquiti	5
SHOC2 mediates the drug-resistance of triple-negative breast cancer cells to everolimus	5
SHR-1806, a robust OX40 agonist to promote T cell-mediated antitumor immunity	5
Epigenetic silencing ZSCAN23 promotes pancreatic cancer growth by activating Wnt signaling	5
Targeting molecular and genetic pathways driving tumorigenesis for precision therapy in colorectal cancer	5
KLF7 enhances the invasion and migration of colorectal cancer cells via the miR-139-5p/TPD52 axis	5
HSPB8-BAG3 chaperone complex modulates cell invasion in intrahepatic cholangiocarcinoma by regulating CASA-mediated Filamin A degradation	5
Arntl-induced upregulation of DUSP1 inhibits tumor progression in esophageal squamous cell carcinoma by inactivating ERK signaling	5
A novel dopamine receptor D2 antagonist (ONC206) potentiates the effects of olaparib in endometrial cancer	5
LncRNA DUXAP8 induces breast cancer radioresistance by modulating the PI3K/AKT/mTOR pathway and the EZH2-E-cadherin/RHOB pathway	5
Genomic profiling, prognosis, and potential interventional targets in young and old patients with cholangiocarcinoma	5
Advances in SEC61G research: from ER translocon subunit to emerging pan-cancer oncogenic roles	5
RET fusion partners dictate oncogenic potential in undifferentiated spindle cell sarcomas	5
Correction	5
Unresectable ectopic hepatocellular carcinoma in the left sub-diaphragmatic area and retroperitoneum treated with TACE: case report and literature review	5
Curcumin analog WZ26 induces ROS and cell death via inhibition of STAT3 in cholangiocarcinoma	5
BTF3 promotes proliferation and glycolysis in hepatocellular carcinoma by regulating GLUT1	5
A pan-cancer analysis of MARCH8: molecular characteristics, clinical relevance, and immuno-oncology features	5
Correction	5
Exosome-transmitted hsa_circ_0012634 suppresses pancreatic ductal adenocarcinoma progression through regulating miR-147b/HIPK2 axis	5
Targeting endoplasmic reticulum associated degradation pathway combined with radiotherapy enhances the immunogenicity of esophageal cancer cells	5
Association between the apoptotic effect of Cabazitaxel and its pro-oxidant efficacy on the redox adaptation mechanisms in prostate cancer cells with different resistance phenotypes	5
Functional validation of somatic variability in TP53 and KRAS for prediction of platinum sensitivity and prognosis in epithelial ovarian c	5