Ocular Surface

Article	Citations
ACE2 and TMPRSS2 are expressed on the human ocular surface, suggesting susceptibility to SARS-CoV-2 infection	230
The evidence of SARS-CoV-2 infection on ocular surface	201
A single cell atlas of human cornea that defines its development, limbal progenitor cells and their interactions with the immune cells	102
Co-expression of SARS-CoV-2 entry genes in the superficial adult human conjunctival, limbal and corneal epithelium suggests an additional route of entry via the ocular surface	100
Prevalence and risk factors of dry eye in 79,866 participants of the population-based Lifelines cohort study in the Netherlands	90
Prevalence of SARS-CoV-2 in human post-mortem ocular tissues	85
The keratoconus enigma: A review with emphasis on pathogenesis	84
Corneal stromal wound healing: Major regulators and therapeutic targets	68
Randomised double-masked placebo-controlled trial of the cumulative treatment efficacy profile of intense pulsed light therapy for meibomian gland dysfunction	66
Fungal keratitis: A review of clinical presentations, treatment strategies and outcomes	59
Assessing the ocular surface microbiome in severe ocular surface diseases	58
Single-cell transcriptomics identifies limbal stem cell population and cell types mapping its differentiation trajectory in limbal basal epithelium of human cornea	56
The gut-eye-lacrimal gland-microbiome axis in Sjögren Syndrome	54
Neurotrophic keratitis: Frequency, etiologies, clinical management and outcomes	53
Use of digital displays and ocular surface alterations: A review	49
Immune - Goblet cell interaction in the conjunctiva	49
Intense pulsed light treatment in meibomian gland dysfunction: A concise review	47
The physical and mental burden of dry eye disease: A large population-based study investigating the relationship with health-related quality of life and its determinants	46
NLRP12- and NLRC4-mediated corneal epithelial pyroptosis is driven by GSDMD cleavage accompanied by IL-33 processing in dry eye	46
Ocular surface microbiota in patients with aqueous tear-deficient dry eye	46
Organoids and organ chips in ophthalmology	44
Association between dry eye and depressive symptoms: Large-scale crowdsourced research using the DryEyeRhythm iPhone application	44
Molecular identity of human limbal heterogeneity involved in corneal homeostasis and privilege	43
The eye as the discrete but defensible portal of coronavirus infection	41
Long-term outcomes of amniotic membrane treatment in acute Stevens-Johnson syndrome/toxic epidermal necrolysis	41

Pigment epithelium-derived factor (PEDF) plays anti-inflammatory roles in the pathogenesis of dry eye disease	40
Demographic and lifestyle risk factors of dry eye disease subtypes: A cross-sectional study	39
Visualization of microneuromas by using in vivo confocal microscopy: An objective biomarker for the diagnosis of neuropathic corneal pain?	39
Safety and feasibility of mesenchymal stem cell therapy in patients with aqueous deficient dry eye disease	39
The relationship between dry eye and sleep quality	38
Predicting the likelihood of need for future keratoplasty intervention using artificial intelligence	37
Tear cytokine levels in the diagnosis and severity assessment of ocular chronic graft-versus-host disease(GVHD)	36
Aggregated neutrophil extracellular traps occlude Meibomian glands during ocular surface inflammation	36
New insights into the lacrimal pump	36
Ageing and the natural history of dry eye disease: A prospective registry-based cross-sectional study	34
Ocular manifestations of anti-neoplastic immune checkpoint inhibitor-associated Stevens-Johnson syndrome/toxic epidermal necrolysis in cancer patients	32
Impact of the COVID-19 pandemic on eye strain and dry eye symptoms	32
Decellularized porcine cornea-derived hydrogels for the regeneration of epithelium and stroma in focal corneal defects	31
High-fat diet induces dry eye-like ocular surface damages in murine	31
The ocular surface immune system through the eyes of aging	31
Pathophysiology of aniridia-associated keratopathy: Developmental aspects and unanswered questions	30
Ocular surface disease associated with dupilumab treatment for atopic diseases	30
Correlation of corneal immune cell changes with clinical severity in dry eye disease: An in vivo confocal microscopy study	30
The molecular basis of neurotrophic keratopathy: Diagnostic and therapeutic implications. A review	29
Latest evidences on meibomian gland dysfunction diagnosis and management	28
Systemic risk factors of dry eye disease subtypes: A New Zealand cross-sectional study	28
TFOS Lifestyle Report: Impact of environmental conditions on the ocular surface	28
Epithelium-derived IL-33 activates mast cells to initiate neutrophil recruitment following corneal injury	27
The role of Th17 immunity in chronic ocular surface disorders	27
Small fiber neuropathy in the cornea of Covid-19 patients associated with the generation of ocular surface disease	27
Interactions of polar lipids with cholesteryl ester multilayers elucidate tear film lipid layer structure	27
Alterations in corneal nerves in different subtypes of dry eye disease: An in vivo confocal microscopy study	27
Management of corneal complications in vernal keratoconjunctivitis: A review	26
Eicosapentaenoic acid (EPA) activates PPARγ signaling leading to cell cycle exit, lipid accumulation, and autophagy in human meibomian gland epithelial cells (hMGEC)	26
Relationships between activated dendritic cells and dry eye symptoms and signs	26
Supramolecular host-guest hyaluronic acid hydrogels enhance corneal wound healing through dynamic spatiotemporal effects	25
Ocular pain response to treatment in dry eye patients	25
Developing evidence-based guidance for the treatment of dry eye disease with artificial tear supplements: A six-month multicentre, double-masked randomised controlled trial	25
Diagnostic armamentarium of infectious keratitis: A comprehensive review	25
Giant papillary conjunctivitis: A review	25
A phase II randomized trial to evaluate the long-term (12-week) efficacy and safety of OC-01 (varenicline solution) nasal spray for dry eye disease: The MYSTIC study	24
Ocular redness – I: Etiology, pathogenesis, and assessment of conjunctival hyperemia	24
Melanocytes as emerging key players in niche regulation of limbal epithelial stem cells	24
Ocular surface diabetic disease: A neurogenic condition?	24
A systematic review of cellular therapies for the treatment of limbal stem cell deficiency affecting one or both eyes	23
Dry eye disease in children and adolescents in India	23
The vision-related burden of dry eye	23
Transcriptomic profiling of human corneal epithelial cells exposed to airborne fine particulate matter (PM2.5)	22
Altered ocular surface immune cell profile in patients with dry eye disease	22
Dry anophthalmic socket syndrome – Standardized clinical evaluation of symptoms and signs	22
Impact of aging on the pathophysiology of dry eye disease: A systematic review and meta-analysis	22
Meibomian gland dysfunction is the primary determinant of dry eye symptoms: Analysis of 2346 patients	22
Abnormal neovascular and proliferative conjunctival phenotype in limbal stem cell deficiency is associated with altered microRNA and gene expression modulated by PAX6 mutational status in congenital a	22
Low-dose naltrexone is effective and well-tolerated for modulating symptoms in patients with neuropathic corneal pain	21
The epidemiology of infectious keratitis	21

A randomized, sham-controlled trial of intraductal meibomian gland probing with or without topical antibiotic/steroid for obstructive meibomian gland dysfunction	21
TFOS Lifestyle: Impact of the digital environment on the ocular surface	21
Interleukin-4 stimulates lipogenesis in meibocytes by activating the STAT6/PPARγ signaling pathway	21
Activation of ocular surface mast cells promotes corneal neovascularization	21
Epidemiology, economic and humanistic burdens of Ocular Surface Chemical Injury: A narrative review	21
Artificial intelligence in dry eye disease	21
Enhanced closed eye neutrophil degranulation in dry eye disease	20
Comparison of clinical characteristics of post-refractive surgery-related and post-herpetic neuropathic corneal pain	20
The utility of anterior segment optical coherence tomography angiography for the assessment of limbal stem cell deficiency	20
Tissue engineered corneal epithelium derived from clinical-grade human embryonic stem cells	20
In-situ porcine corneal matrix hydrogel as ocular surface bandage	20
SARS-CoV-2 receptor ACE2 is expressed in human conjunctival tissue, especially in diseased conjunctival tissue	20
Role of optical coherence tomography angiography in the characterization of vascular network patterns of ocular surface squamous neoplasia	20
DryEyeRhythm: A reliable and valid smartphone application for the diagnosis assistance of dry eye	20
Corneal neurotization for neurotrophic keratopathy: Review of surgical techniques and outcomes	20
Membrane-associated mucins of the human ocular surface in health and disease	19
Conjunctival transcriptome analysis reveals the overexpression of multiple pattern recognition receptors in vernal keratoconjunctivitis	19
Matrix metalloproteinase 9 positivity predicts long term decreased tear production	19
Lid margin keratinization in Stevens-Johnson syndrome: Review of pathophysiology and histopathology	19
Pigment Epithelium-derived Factor secreted by corneal epithelial cells regulates dendritic cell maturation in dry eye disease	19
Sex and age differences in symptoms and signs of dry eye disease in a Norwegian cohort of patients	19
Repurposing medications	18
Decellularized porcine conjunctiva as an alternative substrate for tissue-engineered epithelialized conjunctiva	18
TFOS Lifestyle: Impact of lifestyle challenges on the ocular surface	18
Dysfunction of the limbal epithelial stem cell niche in aniridia-associated keratopathy	18
Relationship between screen time and dry eye symptoms in pediatric population during the COVID-19 pandemic	18
Type 1 diabetes mellitus impairs diurnal oscillations in murine extraorbital lacrimal glands	17
New insight into lacrimal gland function: Role of the duct epithelium in tear secretion	17
The use of in vivo confocal microscopy in fungal keratitis – Progress and challenges	17
SARS-CoV-2 and its beta variant of concern infect human conjunctival epithelial cells and induce differential antiviral innate immune response	17
Advances in the management of Acanthamoeba keratitis: A review of the literature and synthesized algorithmic approach	17
Topical glaucoma medications – Clinical implications for the ocular surface	17
Efficacy and tolerability of nortriptyline in the management of neuropathic corneal pain	17
Corneal lymphangiogenesis in dry eye disease is regulated by substance P/neurokinin-1 receptor system through controlling expression of vascular endothelial growth factor receptor 3	16
Alteration in meibum lipid composition and subjective symptoms due to aging and meibomian gland dysfunction	16
Retroprosthetic membrane: A complication of keratoprosthesis with broad consequences	16
Association of dry eye disease and sun exposure in geographically diverse adult (≥40 years) populations of India: The SEED (sun exposure, environment and dry eye disease) study - Second report of the	16
The role of meibography in ocular surface diagnostics: A review	16
Clinical practice patterns in the management of dry eye disease: A TFOS international survey	16
Prior inhibition of AKT phosphorylation by BX795 can define a safer strategy to prevent herpes simplex virus-1 infection of the eye	16
The role of nitric oxide in ocular surface physiology and pathophysiology	15
Human meibum and tear film derived (O-acyl)-omega-hydroxy fatty acids in meibomian gland dysfunction	15
TFOS lifestyle: Impact of societal challenges on the ocular surface	15
IL-36α/IL-36RA/IL-38 signaling mediates inflammation and barrier disruption in human corneal epithelial cells under hyperosmotic stress	15
The link between Keratoconus and posterior segment parameters: An updated, comprehensive review	15
Long-term outcomes of cultivated cell sheet transplantation for treating total limbal stem cell deficiency	14
Efficacy of cyanoacrylate tissue adhesive in the management of corneal thinning and perforation due to microbial keratitis	14
TFOS Lifestyle: Impact of elective medications and procedures on the ocular surface	14
TFOS Lifestyle: Impact of cosmetics on the ocular surface	14
Safety and efficacy of UV application for superficial infections in humans: A systematic review and meta-analysis	14
Relationship between unhealthy sleep status and dry eye symptoms in a Japanese population: The JPHC-NEXT study	14
Ocular surface disease in thyroid eye disease: A narrative review	14
TFOS Lifestyle: Impact of nutrition on the ocular surface	14
The relationship between alcohol consumption and dry eye	14
Resident plasmacytoid dendritic cells patrol vessels in the naïve limbus and conjunctiva	14
The potential of lipid mediator networks as ocular surface therapeutics and biomarkers	13
The effects of systemic cyclosporine in acute Stevens-Johnson syndrome/toxic epidermal necrolysis on ocular disease	13
Light cycle phase advance as a model for jet lag reprograms the circadian rhythms of murine extraorbital lacrimal glands	13
The impact of anticancer drugs on the ocular surface	13
Modulating the tachykinin: Role of substance P and neurokinin receptor expression in ocular surface disorders	13
Drug induced cicatrizing conjunctivitis: A case series with review of etiopathogenesis, diagnosis and management	13
A reliable animal model of corneal stromal opacity: Development and validation using in vivo imaging	13
Automated quantification of meibomian gland dropout in infrared meibography using deep learning	13
RvE1 uses the LTB4 receptor BLT1 to increase [Ca2+]i and stimulate mucin secretion in cultured rat and human conjunctival goblet cells	12
Prophylactic action of lipid and non-lipid tear supplements in adverse environmental conditions: A randomised crossover trial	12
Assessment of response to multimodal management of neurotrophic corneal disease	12
Epigenetic regulation of anterior segment diseases and potential therapeutics	12
Randomized trial of topical periocular castor oil treatment for blepharitis	12
Efficacy and retention of silicone punctal plugs for treatment of dry eye in patients with and without ocular graft-versus-host-disease	12
Regulatory role of miR-146a in corneal epithelial wound healing via its inflammatory targets in human diabetic cornea	12
Neuroanatomy and neurochemistry of rat cornea: Changes with age	12
Relationship between eyelid margin irregularity and meibomian gland dropout	12
Toward electron-beam sterilization of a pre-assembled Boston keratoprosthesis	12
Dihydrotestosterone suppression of proinflammatory gene expression in human meibomian gland epithelial cells	12
Efficacy and outcome of simple limbal epithelial transplantation for limbal stem cell deficiency verified by epithelial phenotypes integrated with clinical evaluation	12
Ocular surface disease associated with immune checkpoint inhibitor therapy	12
Cytomorphological assessment of the lid margin in relation to symptoms, contact lens wear and lid wiper epitheliopathy	11
Saturation of cholesteryl esters produced by human meibomian gland epithelial cells after treatment with rosiglitazone	11
Creation and grading of experimental corneal scars in mice models	11
Spontaneous face- and eye-touching: Infection risk versus potential microbiome gain	11

Mesenchymal stromal cells for corneal transplantation: Literature review and suggestions for successful clinical trials	11
Association of meibomian gland morphology with symptoms and signs of dry eye disease in the Dry Eye Assessment and Management (DREAM) study	11
TFOS European Ambassador meeting: Unmet needs and future scientific and clinical solutions for ocular surface diseases	11
Meibum sphingolipid composition is altered in individuals with meibomian gland dysfunction-a side by side comparison of Meibum and Tear Sphingolipids	11
Medication use and dry eye symptoms: A large, hypothesis-free, population-based study in the Netherlands	11
Predictive factors of Boston Type I Keratoprosthesis outcomes: A long-term analysis	11
TFOS Lifestyle: Impact of contact lenses on the ocular surface	11
Latest developments in meibography: A review	10
Endocrine disrupting chemicals associated with dry eye syndrome	10
Normalized ocular surface temperature models for tear film characteristics and dry eye disease evaluation	10
Meibomian gland dysfunction is suppressed via selective inhibition of immune responses by topical LFA-1/ICAM antagonism with lifitegrast in the allergic eye disease (AED) model	10
Association of meibomian gland architecture and body mass index in a pediatric population	10
Infrared meibography allows detection of dimensional changes in meibomian glands following intranasal neurostimulation	10
Meibomian gland dropout is associated with immunodeficiency at HIV diagnosis: Implications for dry eye disease	10
Salivary gland transplantation for dry eye disease: Indications, techniques, and outcomes	10
The conjunctival extracellular matrix, related disorders and development of substrates for conjunctival restoration	10
TFOS Lifestyle - Evidence quality report: Advancing the evaluation and synthesis of research evidence	10
Lacrimal gland regeneration: The unmet challenges and promise for dry eye therapy	10
Impaired GSH biosynthesis disrupts eye development, lens morphogenesis and PAX6 function	10
Surgical management of infectious keratitis	10
2D fourier transform for global analysis and classification of meibomian gland images	10
Human meibum and tear film derived cholesteryl and wax esters in meibomian gland dysfunction and tear film structure	10
Human precorneal tear film and lipid layer dynamics in meibomian gland dysfunction	10
Neuronal-epithelial cell alignment: A determinant of health and disease status of the cornea	10
Characterising the ocular surface and tear film in a population-based birth cohort of 45-year old New Zealand men and women	10
A multicenter report of the use of plasma rich in growth factors (PRGF) for the treatment of patients with ocular surface diseases in North America	10
Symptom improvement in dry eye subjects following intranasal tear neurostimulation: Results of two studies utilizing a controlled adverse environment	10
Understanding chronic ocular surface pain: An unmet need for targeted drug therapy	9
Concurrent ocular pain in patients with neurotrophic keratopathy	9
Evaluating the clinical translational relevance of animal models for limbal stem cell deficiency: A systematic review	9
The Role of Multisystem Disease in Composition of Autologous Serum tears and ocular surface symptom improvement	9
The Link module of human TSG-6 (Link_TSG6) promotes wound healing, suppresses inflammation and improves glandular function in mouse models of Dry Eye Disease	9
Geographic distribution of corneal staining in symptomatic dry eye	9
Multicenter prospective validation study for international chronic ocular graft-versus-host disease consensus diagnostic criteria	9
Dry eye disease flares: A rapid evidence assessment	9
Anterior segment optical coherence tomography angiography in the assessment of ocular surface lesions	9
Whole exome profiling and mutational analysis of Ocular Surface Squamous Neoplasia	9
High resolution three-dimensional imaging of the ocular surface and intact eyeball using tissue clearing and light sheet microscopy	9
Profile of tear lipid mediator as a biomarker of inflammation for meibomian gland dysfunction and ocular surface diseases: Standard operating procedures	9
Nicotinic acetylcholine receptor stimulation: A new approach for stimulating tear secretion in dry eye disease	8
Management of corneal melt in patients with Boston Keratoprosthesis Type 1: Repair versus repeat	8
Spontaneous acinar and ductal regrowth after meibomian gland atrophy induced by deletion of FGFR2 in a mouse model	8
Herpes simplex virus, varicella-zoster virus and cytomegalovirus keratitis: Facts for the clinician	8
Effect of therapeutic UVC on corneal DNA: Safety assessment for potential keratitis treatment	8
Capsaicin-induced pain sensitivity in short tear break-up time dry eye	8
Updates in diagnostics, treatments, and correlations between oral and ocular manifestations of Sjogren's syndrome	8
The pattern of the inferocentral whorl region of the corneal subbasal nerve plexus is altered with age	8
Tear metabolomics highlights new potential biomarkers for differentiating between Sjögren's syndrome and other causes of dry eye	8
Dry eye disease and proteomics	8
The impact of euthanasia and enucleation on mouse corneal epithelial axon density and nerve terminal morphology	8
Aftermarket effects of cenegermin for neurotrophic keratopathy in pediatric patients	8
Topical use of alcohol in ophthalmology - Diagnostic and therapeutic indications	8
Biological tissues and components, and synthetic substrates for conjunctival cell transplantation	8
A surgical skills assessment rubric for pterygium surgery	8
A randomized, vehicle-controlled, Phase 2b study of two concentrations of the TRPM8 receptor agonist AR-15512 in the treatment of dry eye disease (COMET-1)	8
Ocular redness – II: Progress in development of therapeutics for the management of conjunctival hyperemia	7
Human meibomian gland epithelial cell culture models: Current progress, challenges, and future directions	7
Herpes Simplex Virus-1 infection in human primary corneal epithelial cells is blocked by a stapled peptide that targets processive DNA synthesis	7
Biomarkers of in vivo limbal stem cell function	7
Anterior-segment spectral domain optical coherence tomography in epidermolysis bullosa	7
Face mask use and effects on the ocular surface health: A comprehensive review	7
Synthetic high-density lipoprotein nanoparticles: Good things in small packages	7
Corneal nerve changes following treatment with neurotoxic anticancer drugs	7
Eyelid blood vessel and meibomian gland changes in a sclerodermatous chronic GVHD mouse model	7
The treatment of recurrent conjunctival and corneal intraepithelial neoplasia with interferon alfa-2b and retinoic acid: ~9 years’ follow-up on tumor control	7
Chemical and thermal ocular burns in the United States: An IRIS registry analysis	7
Pain sensitivity and autonomic nervous system parameters as predictors of dry eye symptoms after LASIK	7
Spontaneous regression of ocular surface squamous neoplasia: Possible etiologic mechanisms in cancer resolution	7
Inducing dry eye disease using a custom engineered desiccation system: Impact on the ocular surface including keratin-14-positive limbal epithelial stem cells	7
Omega-3 polyunsaturated fatty acids and corneal nerve health: Current evidence and future directions	7
5-Fluorouracil in primary, impending recurrent and recurrent pterygium: Systematic review of the efficacy and safety of a surgical adjuvant and intralesional antimetabolite	7
In vivo confocal microscopic study of corneal innervation in Sjögren's Syndrome with or without small fiber neuropathy	7
Antibiotic treatment for dry eye disease related to meibomian gland dysfunction and blepharitis – A review	7
Safety and feasibility of subconjunctival injection of mesenchymal stem cells for acute severe ocular burns: A single-arm study	7
High expression of SARS-CoV2 viral entry-related proteins in human limbal stem cells	7
Detecting dry eye from ocular surface videos based on deep learning	7
High fat diet induced gut dysbiosis alters corneal epithelial injury response in mice	7
Combinatorial therapy with immunosuppressive, immunomodulatory and tear substitute eyedrops (“Triple Play”) in Recalcitrant Immunological Ocular Surface Diseases	7
Immune signaling in rosacea	7
Expression of Acyl-CoA wax-alcohol acyltransferase 2 (AWAT2) by human and rabbit meibomian glands and meibocytes	7
Characterization of the thickness of the Tear Film Lipid Layer in Meibomian Gland Dysfunction using high resolution optical microscopy	6
Chronic ocular complications in lamotrigine vs. trimethoprim-sulfamethoxazole induced Stevens-Johnson syndrome/toxic epidermal necrolysis	6
Change of tear lipid mediators in a post-trabeculectomy cohort	6
Bacterial contamination of intravitreal needles by the ocular surface microbiome	6
Atypical microbial keratitis	6
Readership awareness series – Paper 4: Chatbots and ChatGPT - Ethical considerations in scientific publications	6
Entry receptor bias in evolutionarily distant HSV-1 clinical strains drives divergent ocular and nervous system pathologies	6
Impact of glaucoma medications on the ocular surface and how ocular surface disease can influence glaucoma treatment	6
Comparison and application of commercially available fibrin sealants in ophthalmology	6
Benzalkonium chloride, a common ophthalmic preservative, compromises rat corneal cold sensitive nerve activity	6
Meibomian gland stem/progenitor cells: The hunt for gland renewal	6
Aqueous humor induces lymphatic regression on the ocular surface	6
Predatory bacteria can reduce Pseudomonas aeruginosa induced corneal perforation and proliferation in a rabbit keratitis model	6
Experimental design considerations for studies of human tear proteins	6
Monkeypox and ocular implications in humans	6