OOIR: Observatory of International Research

Papers

(The TQCC of Ocular Surface is 12. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2022-08-01 to 2026-08-01.)

Article	Citations
Editorial Board	142
Reassessing interdisciplinary approaches to belantamab mafodotin-induced ocular toxicity: Towards a standardized collaborative model	123
In vivo calcium imaging of corneal sensory nerves with fluorescent stereoscopic microscopy	115
Long term study of topical interferon α-2b eye drops as primary treatment of ocular surface squamous neoplasia	85
Monkeypox and ocular implications in humans	81
Corrigendum to “New insights into lacrimal gland anatomy using 7T MRI and electron microscopy: Relevance for lacrimal gland targeted therapies and bioengineering” [Ocul. Surf. 30 (October 2023) 204–21	73
Economic burden of keratitis patients with inpatient care: a nationwide, multicenter registry study	64
Endogenous TSG-6 modulates corneal inflammation following chemical injury	59
Biology and medicine on ocular surface restoration: Advancements and limits of limbal stem cell deficiency treatments	58
Atypical microbial keratitis	58
Safety of subconjunctival injection of mesenchymal stromal cells in persistent corneal epithelial disease – A phase 1b clinical trial	56
Development and validation of a method to generate phenol red thread tests	52
Readership awareness series – Paper 10: Open Access Publishing	51
Mechanistic insights into conjunctivalization in limbal stem cell deficiency using a lineage tracing approach	49
The clinical outcomes of minor salivary gland transplantation for severe dry eye disease secondary to chronic Stevens-Johnson syndrome	49
Diagnostic performance and optimal cut-off values for tear film lipid layer grading and thickness in dry eye disease: An investigator-masked, randomised crossover study	46
A prospective self-controlled study on the alterations of the ocular surface and conjunctival transcriptomic profile associated with prolonged exposure to video display terminals	45
Editorial Board	45
Herpes simplex virus, varicella-zoster virus and cytomegalovirus keratitis: Facts for the clinician	43
Organotypic culture model of mouse meibomian gland as a screening platform for risk factors related to meibomian gland dysfunction	40
Chronic inflammation as a proposed risk factor for ocular surface squamous neoplasia	39
Epidemiology and risk factors for the development of cicatrizing conjunctivitis in chronic ocular graft-versus-host disease	38
Effects of age on lacrimal gland bioactive lipids	37
Corneal gene therapy: Structural and mechanistic understanding	35
Metabolic reprogramming in lacrimal gland GVHD: Stage-specific shifts in acinar cells as drivers of disease progression	35

A pilot randomized controlled trial of topical androgen treatment in dry eye	33
Tear film changes in symptomatic versus asymptomatic video display terminal users following computer challenge test	33
Allogeneic mesenchymal stem cell therapy for dry eye disease in patients with Sjögren's syndrome: A randomized clinical trial	32
Predatory bacteria can reduce Pseudomonas aeruginosa induced corneal perforation and proliferation in a rabbit keratitis model	32
Radiofrequency treatment for meibomian gland dysfunction: A randomized controlled trial	31
New disposable esthesiometer (KeraSenseⓇ) to improve diagnosis and management of neurotrophic keratitis	30
TFOS Lifestyle: Impact of nutrition on the ocular surface	29
Interdisciplinary management of belantamab mafodotin-associated ocular toxicity in clinical practice	29
Toxicity and efficacy of type I interferons on the ocular surface: in vitro, animal, and clinical studies	29
A loss of inter-α-inhibitor Heavy Chain 5 (ITIH5) leads to corneal thinning and increased corneal inflammation following injury and early onset geriatric decline	28
Profile of tear lipid mediator as a biomarker of inflammation for meibomian gland dysfunction and ocular surface diseases: Standard operating procedures	28
Topical low-dose heparin in ocular Stevens Johnson Syndrome and associated molecular correlations: A randomized controlled pilot study	28
Cytokine levels and clinical characteristics in the tear fluid of patients with atopic dermatitis and atopic keratoconjunctivitis	26
5-Fluorouracil in primary, impending recurrent and recurrent pterygium: Systematic review of the efficacy and safety of a surgical adjuvant and intralesional antimetabolite	26
Alteration in meibum lipid composition and subjective symptoms due to aging and meibomian gland dysfunction	25
TFOS Lifestyle Report: Impact of environmental conditions on the ocular surface	25
Trustworthy research presentations	24
Subconjunctival triamcinolone injection for infectious necrotizing scleritis	23
Insights into the clinical development of regenerative medical products through a comparison of three cell-based products recently approved for limbal stem cell deficiency	23
Effect of cosmetics on the measurement of the tear lipid layer thickness by LipiView®	23
Readership awareness series – Paper 3: Paper mills	23
Keratoneuropathy	23
Expert consensus on pediatric dry eye: Insights from a European Delphi study	23
Label-free quantitative imaging of conjunctival goblet cells	22
Redefining ocular drug delivery	22
Rational design and synthesis of lumican stapled peptides for promoting corneal wound healing	22
Age-related dry eye disease: Redefining a distinct subtype driven by aging	21
Investigating conjunctival immune pathways in Sjögren and non-Sjögren disease associated dry eye	21
Readership awareness series - Paper 6: How to write a good peer review report?	21
Corneal nerve regeneration is affected by scar location in herpes simplex keratitis: A longitudinal in vivo confocal microscopy study	21
Host-microbe interactions in cornea	21
Ocular pain in ocular graft-versus-host disease patients with neurotrophic keratopathy	21
1,5-Dicaffeoylquinic acid from Pseudognaphalium affine ameliorates dry eye disease via suppression of inflammation and protection of the ocular surface	21
Re: Significant errors in the paper by Ballesteros-Sánchez A, Rocha-de-Lossada C and Sánchez-González J. Efficacy of eyelid warming devices as first-step treatment in meibomian gland dysfunction: A sy	20
Optimising the method for visualising mouse meibomian gland using eyelid whole-mount lipid staining	20
Corrigendum to “Models for Meibomian gland dysfunction: In vivo and in vitro”, Review article [Ocul. Surf. 32 (2024) 154–165]	20
Identifying patient-valued outcomes for use in early phase trials of ocular surface disease interventions	20
Conjunctival vessel density analysis as a marker of inflammation in dry eye disease	20
Changes in conjunctival mononuclear phagocytes and suppressive activity of regulatory macrophages in desiccation induced dry eye	20
Phenotypic characterization of patients developing chronic dry eye and pain after refractive surgery: A cross-sectional study	20
A novel artificial intelligence model for diagnosing Acanthamoeba keratitis through confocal microscopy	20
Intralesional triamcinolone injection as an adjuvant therapy for refractory cicatrizing conjunctivitis	20
Visual outcomes of children undergoing penetrating keratoplasty in the US	20
Autologous serum tears improve corneal nerve density and sensitivity in patients with ocular graft-versus-host disease-associated dry eye disease	20
Smad4 deficiency ameliorates the progressive corneal stroma thinning caused by the loss of Tbr1	19
Use of a transgenic mouse model for in vivo monitoring of corneal pathologies following Sulfur Mustard Exposure	19
Fenofibrate ameliorates ocular surface inflammation in diabetic keratopathy	19
High-resolution high-contrast in vivo phase imaging of corneal nerves and immune cells in mice	19
Deep learning-based classification of fungal and Acanthamoeba keratitis using confocal microscopy	18
Evaluation of ocular neuropathic pain	18

Corneal sensory nerve regulation of tear production through stimulation of transient receptor potential melastatin 8 (TRPM8) channel: A potential new approach for treating dry eye disease	18
Report on the 2021 Aniridia North America symposium on PAX6, aniridia, and beyond	18
Transglutaminase-2 is critical for corneal epithelial barrier function via positive regulation of Claudin-1	18
Two models of the structures of the lamellae in human meibum and the tear film lipid layer, TFLL	18
Readership awareness series – Paper 11: Copyright licensing for scientific publications	18
Corneal complications of Sjögren's disease: Insights from a large tertiary ophthalmological care center	18
BMAL1 deficiency provokes dry mouth and eyes by down-regulating ITPR2/3	17
Corrigendum to “TFOS lifestyle: Impact of lifestyle challenges on the ocular surface” [Ocul Surf 28 (2023) 262–303]	17
Novel characterization of CXCR4 expressing cells in uninfected and herpes simplex virus-1 infected corneas	17
Pipeline: Ocular biostatistics: Proper use of proportions	17
Ocular surface squamous neoplasia: Update on genetics, epigenetics and opportunities for targeted therapy	17
Readership awareness series - Paper 1: Ghost authorship	17
Benzalkonium chloride, a common ophthalmic preservative, compromises rat corneal cold sensitive nerve activity	16
Exploration of imaging and molecular biomarkers for differentiation of neuropathic corneal pain from dry eye syndrome	16
Hyperosmotic stress-induced NLRP3 inflammasome activation via the mechanosensitive PIEZO1 channel in dry eye corneal epithelium	16
Ocular graft-versus-host disease: Experience, incidence, and treatment outcomes at a university-based tertiary care ophthalmology center	16
Downregulation of the core circadian gene Nr1d2 in the lacrimal gland contributes to postoperative dry eye disease by impairing lipid metabolism	16
Essential roles of sensory nerve in maintenance of cornea-phenotype in mice	16
Impact of particulate matter and air pollution on ocular surface disease: A systematic review of preclinical and clinical evidence	16
Pipeline: US FDA efficacy requirements for treatment of ocular surface disease: Drugs vs. medical devices	15
Development and optimization of an ex vivo model of corneal epithelium damage with 1-heptanol: Investigating the influence of donor clinical parameters and MSC-sEV treatment on healing capacity	15
Response to “Methodological considerations regarding 'Ranking the efficacy of topical treatments for ocular allergy: A network meta-analysis of current evidence'”	15
Spontaneous acinar and ductal regrowth after meibomian gland atrophy induced by deletion of FGFR2 in a mouse model	15
Intelligent interferometric analysis of lipid layer thickness for clinical evaluation of dry eye disease	15
Tetraspanin CD9-derived peptides inhibit Pseudomonas aeruginosa corneal infection and aid in wound healing of corneal epithelial cells	15
A randomized, vehicle-controlled, Phase 2b study of two concentrations of the TRPM8 receptor agonist AR-15512 in the treatment of dry eye disease (COMET-1)	15
Association between systemic medication use and severity of dry eye signs and symptoms in the DRy eye assessment and management (DREAM) study	15
Contact-mode fluorescence imaging for multi-regional assessment of conjunctival goblet cells in humans	15
Pipeline: Therapeutics – Two views of off-label use	15
The effect of botulinum neurotoxin A injections on meibomian glands and dry eye	15
IVCM image analysis for limbal stem cell deficiency: quantitative diagnostics of the corneal epithelium post-transplant recovery	15
Preservatives and ocular surface disease: A review	14
Editorial Board	14
Readership awareness series – Paper 7: An overview of impact factor and other scientometrics	14
Letter to the editor regarding “TFOS Lifestyle: Impact of the digital environment on the ocular surface”	14
Mechanoreceptor Piezo1 channel-mediated interleukin expression in conjunctival epithelial cells: Linking mechanical stress to ocular inflammation	13
Adipose-derived mesenchymal stromal cells: A study on safety and efficacy in ocular inflammation	13
Letter to Editor: Prospective consecutive case series of patients with neurotrophic keratopathy associated with unilateral total limbal stem cell deficiency caused by severe ocular surface burns	13
Endoplasmic reticulum stress contributes to the development of ocular graft-vs-host disease in the eyelids and the ocular surface	13
A novel Schirmer strip-based tear matrix metalloproteinase measurement in dry eye evaluation	13
Epithelial-mesenchymal transition in the lacrimal gland morphogenesis, damage and repair	13
Delphi panel on neuromodulation as a treatment strategy for dry eye disease: Unlocking the potential of natural tear production	13
Cellular senescence promotes meibomian gland dysfunction in a chronic graft-versus-host disease mouse model	13
Intrinsic regeneration mechanisms of murine lacrimal gland epithelial cells for therapeutic applications in aqueous-deficient dry eye disease	13
Pard3 promotes corneal epithelial stratification and homeostasis by regulating apical-basal polarity, cytoskeletal organization and tight junction-mediated barrier function	13
Duloxetine enhances PAX6 expression and suppresses innate immune responses in murine LPS-induced corneal inflammation	12
Editorial Board	12
Pediatric vs adult Stevens Johnson syndrome/toxic epidermal necrolysis: Ocular outcomes and the role of amniotic membrane	12
Global burden, risk factors, causative organisms and antibiotic susceptibility patterns in bacterial keratitis	12
Editorial Board	12
Glycoprotein 340 expression in hyperosmolar stress and infection of corneal epithelial cells	12
Restoration of corneal epithelial barrier function: A possible target for corneal neovascularization	12
A prospective, longitudinal study to assess progression of ocular surface signs, tear cytokines and protein profiles in young adults	12
The genus decision: Potential impact on ophthalmic pharmaceuticals	12