OOIR: Observatory of International Research

Papers

(The TQCC of Ocular Surface is 11. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-04-01 to 2025-04-01.)

Article	Citations
New-onset keratitis associated with epidermal growth factor receptor-based targeted therapies in Han Chinese patients with lung cancer: A multi-center cohort study	140
Molecular nature of ocular surface barrier function, diseases that affect it, and its relevance for ocular drug delivery	111
Effects of Panretinal photocoagulation on the ocular surface and tear film	82
Atypical microbial keratitis	75
A phase 2a, double-masked, randomized, vehicle-controlled trial of VVN001 in subjects with dry eye disease	63
Reply to the letter-to-the-editor: Morphological retinal changes in keratoconus	61
Readership awareness series - Paper 1: Ghost authorship	59
Genetic predisposition to ocular surface disorders and opportunities for gene-based therapies	58
Patients with neurotrophic keratitis demonstrate alterations in ocular surface expression of transient receptor potential (TRP) channels	57
Pipeline: Ocular biostatistics: Proper use of proportions	57
Managing chronic inflammation in ocular sequelae of Stevens Johnson Syndrome to restore vision	56
Artificial intelligence in dry eye disease	50
Monkeypox and ocular implications in humans	47
Relationship between unhealthy sleep status and dry eye symptoms in a Japanese population: The JPHC-NEXT study	46
The effect of botulinum neurotoxin A injections on meibomian glands and dry eye	45
Ocular surface squamous neoplasia: Update on genetics, epigenetics and opportunities for targeted therapy	42
Pipeline: Pricing for drugs treating dry eye disease	42
A systematic review assessing the quality of patient reported outcome measures in ocular surface disease	41
Destructive and protective effects and therapeutic targets of IL-36 family cytokines in dry eye disease	39
Clinical practice patterns in the management of dry eye disease: A TFOS international survey 2023-24	38
Differential homing of monocytes and neutrophils in the epithelial layer of HSV-1 infected cornea regulates viral dissemination and wound healing	38
Editorial Board	37
Hyperosmotic stress-induced NLRP3 inflammasome activation via the mechanosensitive PIEZO1 channel in dry eye corneal epithelium	37
Mpox Virus and its ocular surface manifestations	36
Dry eye disease and proteomics	35

Anomaly of cornea and ocular adnexa in spinster homolog 2 (Spns2) knockout mice	34
The micronucleus cytome assay – A fast tool for DNA damage screening in human conjunctival epithelial cells	34
A randomized, vehicle-controlled, Phase 2b study of two concentrations of the TRPM8 receptor agonist AR-15512 in the treatment of dry eye disease (COMET-1)	34
The Link module of human TSG-6 (Link_TSG6) promotes wound healing, suppresses inflammation and improves glandular function in mouse models of Dry Eye Disease	34
The prevalence and recurrence risk of bare sclera pterygium surgery in the United States	34
Anterior segment optical coherence tomography angiography in the assessment of ocular surface lesions	33
β-Catenin gain of function mutant in mouse periocular neural crest-derived mesenchymal cells impairs embryonic eyelid morphogenesis and leads to blepharophimosis syndrome in mice	32
BMAL1 deficiency provokes dry mouth and eyes by down-regulating ITPR2/3	32
Human meibum and tear film derived (O-acyl)-omega-hydroxy fatty acids in meibomian gland dysfunction	30
New insights into lacrimal gland anatomy using 7T MRI and electron microscopy: Relevance for lacrimal gland targeted therapies and bioengineering	29
Human meibomian gland epithelial cell culture models: Current progress, challenges, and future directions	29
Endogenous TSG-6 modulates corneal inflammation following chemical injury	28
Therapeutic efficacy of topical blockade of substance P in experimental allergic red eye	28
Readership awareness series - Paper 5: The peer review process	28
Development and validation of a method to generate phenol red thread tests	28
Corrigendum to ‟Non-invasive high-contrast imaging of conjunctival goblet cells for the precision diagnosis of ocular surface diseasesˮ [Ocul Surf 24 (2022) 100–102]	28
Big-bubble DALK: A technique in evolution	27
Readership awareness series – Paper 11: Copyright licensing for scientific publications	27
Aggregated neutrophil extracellular traps occlude Meibomian glands during ocular surface inflammation	27
Saturation of cholesteryl esters produced by human meibomian gland epithelial cells after treatment with rosiglitazone	26
Molecular identity of human limbal heterogeneity involved in corneal homeostasis and privilege	26
Novel characterization of CXCR4 expressing cells in uninfected and herpes simplex virus-1 infected corneas	25
Dry eye disease sustainability	25
The impact of contact lenses on meibomian gland morphology	25
Chemical and thermal ocular burns in the United States: An IRIS registry analysis	25
The antipsychotropic drug Duloxetine rescues PAX6 haploinsufficiency of mutant limbal stem cells through inhibition of the MEK/ERK signaling pathway	24
Efficacy and safety of AZR-MD-001 selenium sulfide ophthalmic ointment in adults with meibomian gland dysfunction: A vehicle-controlled, randomized clinical trial	24
New trends towards glaucoma treatment: Topical osmoprotective microemulsions loaded with latanoprost	23
Seeing the unseen: Use of a modified OSDI questionnaire to accurately detect chronic ocular GVHD in a hematology clinic	23
Imbalanced IL-37/TNF-α/CTSS signaling disrupts corneal epithelial barrier in a dry eye model in vitro	23
Corrigendum to “TFOS lifestyle: Impact of lifestyle challenges on the ocular surface” [Ocul Surf 28 (2023) 262–303]	22
Corrigendum to “Human precorneal tear film and lipid layer dynamics in meibomian gland dysfunction” [Ocul Surf 21 (2021) 250–256]	22
Corrigendum to “New insights into lacrimal gland anatomy using 7T MRI and electron microscopy: Relevance for lacrimal gland targeted therapies and bioengineering” [Ocul. Surf. 30 (October 2023) 204–21	21
Blinded by smoke: Wildfire smoke exposure and eye irritation in australian wildland firefighters	21
Scrambler therapy as a novel treatment for unilateral ocular neuropathic pain	21
Ocular surface disease associated with immune checkpoint inhibitor therapy	20
Editorial Board	20
Comparative analysis of human tear fluid and aqueous humor proteomes	19
Induction of meibocyte differentiation by three-dimensional, matrigel culture of immortalized human meibomian gland epithelial cells to form acinar organoids	19
Impact of aging on the pathophysiology of dry eye disease: A systematic review and meta-analysis	19
Alleviating experimental allergic eye disease by inhibiting pro-lymphangiogenic VEGFR3 signal	19
Impact of particulate matter and air pollution on ocular surface disease: A systematic review of preclinical and clinical evidence	19
Antibiotic treatment for dry eye disease related to meibomian gland dysfunction and blepharitis – A review	18
Safety and feasibility of subconjunctival injection of mesenchymal stem cells for acute severe ocular burns: A single-arm study	18
Pathophysiology of aniridia-associated keratopathy: Developmental aspects and unanswered questions	18
Biology and medicine on ocular surface restoration: Advancements and limits of limbal stem cell deficiency treatments	18
TNF is a critical cytokine in age-related dry eye disease	18
Automated quantification of meibomian gland dropout in infrared meibography using deep learning	18
Altered ocular surface immune cell profile in patients with dry eye disease	18
Glycosaminoglycans: Roles in wound healing, formation of corneal constructs and synthetic corneas	17

Effect of therapeutic UVC on corneal DNA: Safety assessment for potential keratitis treatment	17
Dysfunction of the limbal epithelial stem cell niche in aniridia-associated keratopathy	17
Long term study of topical interferon α-2b eye drops as primary treatment of ocular surface squamous neoplasia	17
A prospective self-controlled study on the alterations of the ocular surface and conjunctival transcriptomic profile associated with prolonged exposure to video display terminals	16
Effects of age on lacrimal gland bioactive lipids	16
Benzalkonium chloride, a common ophthalmic preservative, compromises rat corneal cold sensitive nerve activity	16
Pipeline: US FDA efficacy requirements for treatment of ocular surface disease: Drugs vs. medical devices	16
Readership awareness series – Paper 10: Open Access Publishing	16
Modified technique for sutureless amniotic membrane transplantation in acute Stevens-Johnson syndrome using fibrin sealant	16
Development and optimization of an ex vivo model of corneal epithelium damage with 1-heptanol: Investigating the influence of donor clinical parameters and MSC-sEV treatment on healing capacity	16
The physical and mental burden of dry eye disease: A large population-based study investigating the relationship with health-related quality of life and its determinants	16
The relationship between dry eye and sleep quality	16
Effects of blinking exercises on palpebral fissure height and tear film parameters	15
Unapproved drugs – A fix to an unintended consequence of an FDA policy	15
A large hypothesis-free proteomics study investigating serum inflammatory markers as biomarkers of dry eye disease	15
Editorial Board	15
Chronic inflammation as a proposed risk factor for ocular surface squamous neoplasia	15
Fluorescein CorneoGraphy (FCG): Use of a repurposed fluorescein imaging technique to objectively standardize corneal staining	14
Maximal tear secretion evoked by controlled stimulation of corneal sensory nerves in healthy individuals and dry eye subjects	14
Editorial Board	14
Editorial Board	14
Editorial Board	14
Was Marilyn Monroe myopic and an early adopter of colored contact lenses? A review of the evidence and the early history of colored contact lenses	14
Pipeline: Ocular biostatistics: Which is better: One or two?	13
Editorial Board	13
New disposable esthesiometer (KeraSenseⓇ) to improve diagnosis and management of neurotrophic keratitis	13
Editorial Board	13
Manufacturing of human corneal endothelial grafts	13
The effects of a steam warming eye mask on the ocular surface and mental health	13
Pigment epithelium-derived factor (PEDF) plays anti-inflammatory roles in the pathogenesis of dry eye disease	13
Efficacy and safety of AZR-MD-001 selenium sulfide ophthalmic ointment in adults with meibomian gland dysfunction over six months of treatment: A Phase 2, vehicle-controlled, randomized extension tria	13
Herpes simplex virus, varicella-zoster virus and cytomegalovirus keratitis: Facts for the clinician	13
A novel severity scoring system for murine ocular graft versus host disease and its correlation with CD3+ T cells in the cornea	13
The clinical outcomes of minor salivary gland transplantation for severe dry eye disease secondary to chronic Stevens-Johnson syndrome	12
Meibomian gland tortuosity, truncation, and dilation in paediatric dry eye disease: A multi-centre, investigator-masked, cross-sectional study	12
Spontaneous acinar and ductal regrowth after meibomian gland atrophy induced by deletion of FGFR2 in a mouse model	12
Preliminary experience & rationale of primary allo Simple Limbal Epithelial Transplantation (SLET) following surgical excision of Ocular Surface Tumors	12
Diagnostic performance and optimal cut-off values for tear film lipid layer grading and thickness in dry eye disease: An investigator-masked, randomised crossover study	12
Dry eye disease and blinking behaviors: A narrative review of methodologies for measuring blink dynamics and inducing blink response	12
Tear metabolomics highlights new potential biomarkers for differentiating between Sjögren's syndrome and other causes of dry eye	12
Association between systemic medication use and severity of dry eye signs and symptoms in the DRy eye assessment and management (DREAM) study	12
Topical anti-glaucoma medications effects on meibomian glands: Systematic review and meta-analysis	12
Dry eye disease flares: A rapid evidence assessment	12
Self-complementary AAV vector therapy for treating corneal cloudiness of mucopolysaccharidosis type VII (MPS VII)	11
Impaired GSH biosynthesis disrupts eye development, lens morphogenesis and PAX6 function	11
The roles of neural adaptation and sensitization in contact lens discomfort	11
Epidemiology and risk factors for the development of cicatrizing conjunctivitis in chronic ocular graft-versus-host disease	11
Deciphering S1P downregulation and sphingolipid homeostasis disruption in fungal keratitis via multi-omics and MALDI-MSI analysis	11
Herpes simplex virus-1 conjunctival dendrite in an immunosuppressed patient	11
Modified Boston Type-II Keratoprosthesis Implantation with Autologous Auricular Cartilage Reinforcement	11
Corneal acetylcholine regulates sensory nerve activity via nicotinic receptors	11
Predatory bacteria can reduce Pseudomonas aeruginosa induced corneal perforation and proliferation in a rabbit keratitis model	11
Tetraspanin CD9-derived peptides inhibit Pseudomonas aeruginosa corneal infection and aid in wound healing of corneal epithelial cells	11
Corneal gene therapy: Structural and mechanistic understanding	11
Understanding chronic ocular surface pain: An unmet need for targeted drug therapy	11