OOIR: Observatory of International Research

Papers

(The TQCC of Ocular Surface is 11. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-12-01 to 2025-12-01.)

Article	Citations
Corrigendum to “New insights into lacrimal gland anatomy using 7T MRI and electron microscopy: Relevance for lacrimal gland targeted therapies and bioengineering” [Ocul. Surf. 30 (October 2023) 204–21	157
Editorial Board	110
Monkeypox and ocular implications in humans	87
Atypical microbial keratitis	81
Effects of Panretinal photocoagulation on the ocular surface and tear film	68
Endogenous TSG-6 modulates corneal inflammation following chemical injury	62
Safety of subconjunctival injection of mesenchymal stromal cells in persistent corneal epithelial disease – A phase 1b clinical trial	58
Economic burden of keratitis patients with inpatient care: a nationwide, multicenter registry study	56
Development and validation of a method to generate phenol red thread tests	54
Dry eye disease and proteomics	53
Long term study of topical interferon α-2b eye drops as primary treatment of ocular surface squamous neoplasia	50
Biology and medicine on ocular surface restoration: Advancements and limits of limbal stem cell deficiency treatments	49
Readership awareness series – Paper 10: Open Access Publishing	46
A prospective self-controlled study on the alterations of the ocular surface and conjunctival transcriptomic profile associated with prolonged exposure to video display terminals	46
Effects of age on lacrimal gland bioactive lipids	45
Epidemiology and risk factors for the development of cicatrizing conjunctivitis in chronic ocular graft-versus-host disease	45
Tear film changes in symptomatic versus asymptomatic video display terminal users following computer challenge test	44
Editorial Board	43
Modulating the tachykinin: Role of substance P and neurokinin receptor expression in ocular surface disorders	42
Organotypic culture model of mouse meibomian gland as a screening platform for risk factors related to meibomian gland dysfunction	41
Corneal gene therapy: Structural and mechanistic understanding	40
New disposable esthesiometer (KeraSenseⓇ) to improve diagnosis and management of neurotrophic keratitis	40
Chronic inflammation as a proposed risk factor for ocular surface squamous neoplasia	40
A pilot randomized controlled trial of topical androgen treatment in dry eye	39
Herpes simplex virus, varicella-zoster virus and cytomegalovirus keratitis: Facts for the clinician	38

Allogeneic mesenchymal stem cell therapy for dry eye disease in patients with Sjögren's syndrome: A randomized clinical trial	36
The clinical outcomes of minor salivary gland transplantation for severe dry eye disease secondary to chronic Stevens-Johnson syndrome	36
Impact of digital screen use and lifestyle factors on dry eye disease in the paediatric population	35
Diagnostic performance and optimal cut-off values for tear film lipid layer grading and thickness in dry eye disease: An investigator-masked, randomised crossover study	35
Predatory bacteria can reduce Pseudomonas aeruginosa induced corneal perforation and proliferation in a rabbit keratitis model	32
Topical low-dose heparin in ocular Stevens Johnson Syndrome and associated molecular correlations: A randomized controlled pilot study	30
Toxicity and efficacy of type I interferons on the ocular surface: in vitro, animal, and clinical studies	30
Profile of tear lipid mediator as a biomarker of inflammation for meibomian gland dysfunction and ocular surface diseases: Standard operating procedures	28
Reconsidering the pathogenesis of chalazion	28
A practical framework for telemedicine in dry eye disease	28
Cyclosporine A 1mg/ml in pediatric blepharokeratoconjunctivitis: Case series of 145 children and young people	28
Limiting plastic waste in dry eye practice for environmental sustainability	27
Alteration in meibum lipid composition and subjective symptoms due to aging and meibomian gland dysfunction	27
Investigating the diagnostic utility of non-invasive tear film stability and breakup parameters: A prospective diagnostic accuracy study	26
TFOS Lifestyle Report: Impact of environmental conditions on the ocular surface	26
5-Fluorouracil in primary, impending recurrent and recurrent pterygium: Systematic review of the efficacy and safety of a surgical adjuvant and intralesional antimetabolite	26
Interdisciplinary management of belantamab mafodotin-associated ocular toxicity in clinical practice	25
TFOS Lifestyle: Impact of nutrition on the ocular surface	25
Keratoneuropathy	24
Trustworthy research presentations	24
Readership awareness series – Paper 3: Paper mills	23
Evaluating the clinical translational relevance of animal models for limbal stem cell deficiency: A systematic review	23
1,5-Dicaffeoylquinic acid from Pseudognaphalium affine ameliorates dry eye disease via suppression of inflammation and protection of the ocular surface	23
Host-microbe interactions in cornea	23
Effect of cosmetics on the measurement of the tear lipid layer thickness by LipiView®	23
Redefining ocular drug delivery	22
Rational design and synthesis of lumican stapled peptides for promoting corneal wound healing	22
Corneal nerve regeneration is affected by scar location in herpes simplex keratitis: A longitudinal in vivo confocal microscopy study	22
Exposure keratopathy in patients undergoing invasive ventilation: Prevalence, severity, and the role of surface lubrication	22
Lacrimal gland regeneration: The unmet challenges and promise for dry eye therapy	22
Subconjunctival triamcinolone injection for infectious necrotizing scleritis	21
Label-free quantitative imaging of conjunctival goblet cells	21
Insights into the clinical development of regenerative medical products through a comparison of three cell-based products recently approved for limbal stem cell deficiency	20
Expert consensus on pediatric dry eye: Insights from a European Delphi study	20
Ocular pain in ocular graft-versus-host disease patients with neurotrophic keratopathy	19
Conjunctival vessel density analysis as a marker of inflammation in dry eye disease	19
Changes in conjunctival mononuclear phagocytes and suppressive activity of regulatory macrophages in desiccation induced dry eye	19
Readership awareness series - Paper 6: How to write a good peer review report?	19
A novel artificial intelligence model for diagnosing Acanthamoeba keratitis through confocal microscopy	19
The evolution of the modified osteo-odonto-keratoprosthesis, its reliability, and long-term visual rehabilitation prognosis: An analytical review	19
Intralesional triamcinolone injection as an adjuvant therapy for refractory cicatrizing conjunctivitis	19
Re: Significant errors in the paper by Ballesteros-Sánchez A, Rocha-de-Lossada C and Sánchez-González J. Efficacy of eyelid warming devices as first-step treatment in meibomian gland dysfunction: A sy	19
Report on the 2021 Aniridia North America symposium on PAX6, aniridia, and beyond	18
Identifying patient-valued outcomes for use in early phase trials of ocular surface disease interventions	18
Use of a transgenic mouse model for in vivo monitoring of corneal pathologies following Sulfur Mustard Exposure	18
Smad4 deficiency ameliorates the progressive corneal stroma thinning caused by the loss of Tbr1	18
Transglutaminase-2 is critical for corneal epithelial barrier function via positive regulation of Claudin-1	17
High expression of SARS-CoV2 viral entry-related proteins in human limbal stem cells	17
Phenotypic characterization of patients developing chronic dry eye and pain after refractive surgery: A cross-sectional study	17
Visual outcomes of children undergoing penetrating keratoplasty in the US	17

Corneal Complications of Sjögren’s Disease: Insights from a Large Tertiary Ophthalmological Care Center.	16
Optimising the method for visualising mouse meibomian gland using eyelid whole-mount lipid staining	16
Corrigendum to “Models for Meibomian gland dysfunction: In vivo and in vitro”, Review article [Ocul. Surf. 32 (2024) 154–165]	16
Morphological characteristics of Meibomian Glands and their Influence on Dry Eye disease in contact lens wearers	16
Two models of the structures of the lamellae in human meibum and the tear film lipid layer, TFLL	16
Non-invasive high-contrast imaging of conjunctival goblet cells for the precision diagnosis of ocular surface diseases	16
Deep learning-based classification of fungal and Acanthamoeba keratitis using confocal microscopy	16
Autologous serum tears improve corneal nerve density and sensitivity in patients with ocular graft-versus-host disease-associated dry eye disease	16
Corneal sensory nerve regulation of tear production through stimulation of transient receptor potential melastatin 8 (TRPM8) channel: A potential new approach for treating dry eye disease	16
Fenofibrate ameliorates ocular surface inflammation in diabetic keratopathy	16
Ocular graft-versus-host disease: Experience, incidence, and treatment outcomes at a university-based tertiary care ophthalmology center	15
Readership awareness series – Paper 11: Copyright licensing for scientific publications	15
Novel characterization of CXCR4 expressing cells in uninfected and herpes simplex virus-1 infected corneas	15
Essential roles of sensory nerve in maintenance of cornea-phenotype in mice	15
Drug induced cicatrizing conjunctivitis: A case series with review of etiopathogenesis, diagnosis and management	15
Benzalkonium chloride, a common ophthalmic preservative, compromises rat corneal cold sensitive nerve activity	15
Evaluation of ocular neuropathic pain	15
The effect of botulinum neurotoxin A injections on meibomian glands and dry eye	14
Corrigendum to “TFOS lifestyle: Impact of lifestyle challenges on the ocular surface” [Ocul Surf 28 (2023) 262–303]	14
Downregulation of the core circadian gene Nr1d2 in the lacrimal gland contributes to postoperative dry eye disease by impairing lipid metabolism	14
Modified technique for sutureless amniotic membrane transplantation in acute Stevens-Johnson syndrome using fibrin sealant	14
BMAL1 deficiency provokes dry mouth and eyes by down-regulating ITPR2/3	14
Exploration of imaging and molecular biomarkers for differentiation of neuropathic corneal pain from dry eye syndrome	14
Readership awareness series - Paper 1: Ghost authorship	14
Pipeline: Ocular biostatistics: Proper use of proportions	14
Hyperosmotic stress-induced NLRP3 inflammasome activation via the mechanosensitive PIEZO1 channel in dry eye corneal epithelium	13
Ocular surface squamous neoplasia: Update on genetics, epigenetics and opportunities for targeted therapy	13
IVCM image analysis for limbal stem cell deficiency: quantitative diagnostics of the corneal epithelium post-transplant recovery	13
Pipeline: US FDA efficacy requirements for treatment of ocular surface disease: Drugs vs. medical devices	13
A randomized, vehicle-controlled, Phase 2b study of two concentrations of the TRPM8 receptor agonist AR-15512 in the treatment of dry eye disease (COMET-1)	13
Development and optimization of an ex vivo model of corneal epithelium damage with 1-heptanol: Investigating the influence of donor clinical parameters and MSC-sEV treatment on healing capacity	13
Response to “Methodological considerations regarding 'Ranking the efficacy of topical treatments for ocular allergy: A network meta-analysis of current evidence'”	13
Impact of particulate matter and air pollution on ocular surface disease: A systematic review of preclinical and clinical evidence	13
Pipeline: Therapeutics – Two views of off-label use	13
Preservatives and ocular surface disease: A review	13
Tetraspanin CD9-derived peptides inhibit Pseudomonas aeruginosa corneal infection and aid in wound healing of corneal epithelial cells	12
Pard3 promotes corneal epithelial stratification and homeostasis by regulating apical-basal polarity, cytoskeletal organization and tight junction-mediated barrier function	12
Mechanoreceptor Piezo1 channel-mediated interleukin expression in conjunctival epithelial cells: Linking mechanical stress to ocular inflammation	12
In vivo confocal microscopic study of corneal innervation in Sjögren's Syndrome with or without small fiber neuropathy	12
Spontaneous acinar and ductal regrowth after meibomian gland atrophy induced by deletion of FGFR2 in a mouse model	12
Endoplasmic reticulum stress contributes to the development of ocular graft-vs-host disease in the eyelids and the ocular surface	12
Association between systemic medication use and severity of dry eye signs and symptoms in the DRy eye assessment and management (DREAM) study	12
Cellular senescence promotes meibomian gland dysfunction in a chronic graft-versus-host disease mouse model	12
Letter to the editor regarding “TFOS Lifestyle: Impact of the digital environment on the ocular surface”	12
Epithelial-mesenchymal transition in the lacrimal gland morphogenesis, damage and repair	12
Duloxetine enhances PAX6 expression and suppresses innate immune responses in murine LPS-induced corneal inflammation	11
Editorial Board	11
Readership awareness series – Paper 7: An overview of impact factor and other scientometrics	11
Restoration of corneal epithelial barrier function: A possible target for corneal neovascularization	11
Adipose-derived mesenchymal stromal cells: A study on safety and efficacy in ocular inflammation	11
Editorial Board	11
A novel Schirmer strip-based tear matrix metalloproteinase measurement in dry eye evaluation	11
Delphi Panel on Neuromodulation as a Treatment Strategy for Dry Eye Disease: Unlocking the Potential of Natural Tear Production	11
Secreted Ly-6/uPAR-related protein-1 (SLURP1) is a pro-differentiation factor that stalls G1-S transition during corneal epithelial cell cycle progression	11