Nature Structural & Molecular Biology

Article	Citations
Publisher Correction: Structure and activation of the RING E3 ubiquitin ligase TRIM72 on the membrane	576
Structural insights into metazoan pretargeting GET complexes	427
Author Correction: Polλ promotes microhomology-mediated end-joining	282
A novel class of inhibitors that disrupts the stability of integrin heterodimers identified by CRISPR-tiling-instructed genetic screens	264
Endocrine resistance and breast cancer plasticity are controlled by CoREST	206
Celebrating Nature Structural & Molecular Biology’s 30th anniversary	203
30 years of structural and molecular biology and counting	180
Accessible technology for diploid high-order 3D human genome analysis	165
Structural basis of branching during RNA splicing	146
Author Correction: Structure of the human K2P13.1 channel reveals a hydrophilic pore restriction and lipid cofactor site	138
Protein import into mitochondria — a new path through the membranes	126
Exploration of novel αβ-protein folds through de novo design	123
Fanconi anemia proteins participate in a break-induced-replication-like pathway to counter replication stress	121
Structural basis for pre-tRNA recognition and processing by the human tRNA splicing endonuclease complex	119
Structural insights into translocation and tailored synthesis of hyaluronan	117
Structure of the HCV glycoprotein	115
Structures of aberrant spliceosome intermediates on their way to disassembly	114
Cryo-EM analysis of complement C3 reveals a reversible major opening of the macroglobulin ring	112
Isoform-resolved mRNA profiling of ribosome load defines interplay of HIF and mTOR dysregulation in kidney cancer	92
Surviving under stress conditions	88
TRIM37 prevents ectopic spindle pole assembly by peptide motif recognition and substrate-dependent oligomerization	82
Structural basis of tRNA recognition by the m3C RNA methyltransferase METTL6 in complex with SerRS seryl-tRNA synthetase	80
Tropomyosin 1-I/C coordinates kinesin-1 and dynein motors during oskar mRNA transport	78
Dissecting the mechanism of CRISPR–Cas technologies to design efficient biotechnologies	77
Shifting our perspective on orphan G protein-coupled receptors	77

The Ruminococcus bromii amylosome protein Sas6 binds single and double helical α-glucan structures in starch	77
Constitutive activation mechanism of a class C GPCR	77
Alternative splicing of CARM1 regulated by LincGET-guided paraspeckles biases the first cell fate in mammalian early embryos	75
Snapshots of actin and tubulin folding inside the TRiC chaperonin	74
Current challenges in understanding the role of enhancers in disease	73
PARylated PDHE1α generates acetyl-CoA for local chromatin acetylation and DNA damage repair	73
Tau modification by the norepinephrine metabolite DOPEGAL stimulates its pathology and propagation	73
Reduction of DHHC5-mediated beclin 1 S-palmitoylation underlies autophagy decline in aging	72
Transcription directionality is licensed by Integrator at active human promoters	72
A PKA inhibitor motif within SMOOTHENED controls Hedgehog signal transduction	72
Ensemble cryo-EM reveals conformational states of the nsp13 helicase in the SARS-CoV-2 helicase replication–transcription complex	71
Uncovering protein glycosylation dynamics and heterogeneity using deep quantitative glycoprofiling (DQGlyco)	71
Studying the impact of the nuclear topography on gene function	69
Binding NEMO: Liquid–liquid phase separation captures immune regulator	68
Dynamic PRC1–CBX8 stabilizes a porous structure of chromatin condensates	66
Nature, more than nurture, of epigenetic states	66
Author Correction: Structural basis of tRNA recognition by the m3C RNA methyltransferase METTL6 in complex with SerRS seryl-tRNA synthetase	66
Transcription start site choice diversifies mRNA isoforms and defines cancer cell behavior	66
Phase separation drives X-chromosome inactivation	65
Cryogenic electron microscopy structures reveal how ATP and DNA binding in MutS coordinates sequential steps of DNA mismatch repair	65
cBAF generates subnucleosomes that expand OCT4 binding and function beyond DNA motifs at enhancers	60
Signal-induced enhancer activation requires Ku70 to read topoisomerase1–DNA covalent complexes	58
THEMIS is a substrate and allosteric activator of SHP1, playing dual roles during T cell development	56
Autoinhibition of a clamp-loader ATPase revealed by deep mutagenesis and cryo-EM	55
Author Correction: Cryo-EM structure of an active central apparatus	55
Building insights into KRAS signaling complexes	55
Structure of adenylyl cyclase 5 in complex with Gβγ offers insights into ADCY5-related dyskinesia	55
Chemical modifications, ions and water molecules in the sub-2 Å resolution structure of the human 80S ribosome	54
A personal perspective of the voltage-gated potassium channel studies	54
Cryo-EM structure of the NDH–PSI–LHCI supercomplex from Spinacia oleracea	52
Cohesin closes the door on coexpression	52
Telomeric 8-oxo-guanine drives rapid premature senescence in the absence of telomere shortening	52
Deadenylation kinetics of mixed poly(A) tails at single-nucleotide resolution	52
Smc5/6 silences episomal transcription by a three-step function	51
Structures of outer-arm dynein array on microtubule doublet reveal a motor coordination mechanism	51
Structures of transcription preinitiation complex engaged with the +1 nucleosome	51
Control of transcription elongation and DNA repair by alarmone ppGpp	50
Microtubule-binding-induced allostery triggers LIS1 dissociation from dynein prior to cargo transport	50
Transcriptional repression upon S phase entry protects genome integrity in pluripotent cells	49
MiOS, an integrated imaging and computational strategy to model gene folding with nucleosome resolution	49
EGOC inhibits TOROID polymerization by structurally activating TORC1	49
Cryo-EM structure of an active central apparatus	47
The conformational landscape of human transthyretin revealed by cryo-EM	47
Rhodopsin-bestrophin fusion proteins from unicellular algae form gigantic pentameric ion channels	47
Understanding ubiquitination in neurodevelopment by integrating insights across space and time	47
Lineage regulators TFAP2C and NR5A2 function as bipotency activators in totipotent embryos	47
Structure and activation of the human autophagy-initiating ULK1C:PI3KC3-C1 supercomplex	47
SCAF1 drives the compositional diversity of mammalian respirasomes	46
DNA methylation restricts coordinated germline and neural fates in embryonic stem cell differentiation	46
Perfect match: PET ligand fits snugly into folded Tau filaments	45

TALEDs complete the toolkit for editing human mitochondrial DNA	45
Functional epigenomics: chromatin complexity untangled	44
Structural basis of hepatitis B virus receptor binding	44
Transcription and replication meet the silent X chromosome territory	44
Na+-V-ATPase inhibitor curbs VRE growth and unveils Na+ pathway structure	44
Condensation of ZFP207 and U1 snRNP promotes spliceosome assembly	44
All roads lead to MRN regulation at telomeres: different paths to one solution	44
Structure and function of the human mitochondrial MRS2 channel	44
Thirty years of structural changes	43
ZBTB16/PLZF regulates juvenile spermatogonial stem cell development through an extensive transcription factor poising network	43
Virtual screen raises hit rate	43
Structural basis for the dynamic chaperoning of disordered clients by Hsp90	42
Mechanistic basis for PYROXD1-mediated protection of the human tRNA ligase complex against oxidative inactivation	42
Guidelines for minimal reporting requirements, design and interpretation of experiments involving the use of eukaryotic dual gene expression reporters (MINDR)	41
STING to the lysosome’s rescue	41
CENP-N promotes the compaction of centromeric chromatin	41
Evolution of a histone variant involved in compartmental regulation of NAD metabolism	41
Diverse activation mechanisms of PI3Ks	41
Finding and recycling stalled spliceosomes	40
Transcription modulates chromatin dynamics and locus configuration sampling	40
Start codon-associated ribosomal frameshifting mediates nutrient stress adaptation	40
Structural plasticity of bacterial ESCRT-III protein PspA in higher-order assemblies	39
Molecular interactions contributing to FUS SYGQ LC-RGG phase separation and co-partitioning with RNA polymerase II heptads	39
Architects of the membrane: structures of eukaryotic choline phosphotransferase 1 and choline/ethanolamine phosphotransferase 1	39
The complexin C-terminal amphipathic helix stabilizes the fusion pore open state by sculpting membranes	39
Pioneer factor Pax7 initiates two-step cell-cycle-dependent chromatin opening	38
RNA polymerase II depletion from the inactive X chromosome territory is not mediated by physical compartmentalization	38
Excited-state observation of active K-Ras reveals differential structural dynamics of wild-type versus oncogenic G12D and G12C mutants	37
Structural basis of circularly permuted group II intron self-splicing	37
Structure and interactions of the endogenous human Commander complex	37
The coupling mechanism of mammalian mitochondrial complex I	37
Transport mechanism of presynaptic high-affinity choline uptake by CHT1	37
MacroH2A1.1 has evolved to let PARP1 do more by loosening its grip on PAR	36
Mitoribosome assembly comes into view	35
Looking back at 2021	35
Cryptic elements of the heat-shock response	35
Hallucination of closed repeat proteins containing central pockets	35
DNA replication at high res	35
High-resolution structures of the SARS-CoV-2 N7-methyltransferase inform therapeutic development	34
Molecular basis of human ATM kinase inhibition	34
Structural insights into the decoding capability of isoleucine tRNAs with lysidine and agmatidine	34
Orchestrating nucleic acid–protein interactions at chromosome ends: telomerase mechanisms come into focus	34
A PAR6–aPKC–LGL structure reveals how LGL antagonizes aPKC	34
cGAMP-activated cGAS–STING signaling: its bacterial origins and evolutionary adaptation by metazoans	34
Regulatory activity is the default DNA state in eukaryotes	34
Fusion proteins form onco-condensates	33
Cryo-EM structures of human RNA polymerase I	33
Mesoscale regulation of microtubule-organizing centers by the E3 ligase TRIM37	33
Structural clues about bridge-mediated lipid transfer	33
Cooperation of chromatin remodeling SWI/SNF complex and pioneer factor AP-1 shapes 3D enhancer landscapes	33
The structural basis of fatty acid elongation by the ELOVL elongases	33
Heritable maintenance of chromatin modifications confers transcriptional memory of interferon-γ signaling	32
Structure of a volume-regulated heteromeric LRRC8A/C channel	32
Structural mechanism for the selective phosphorylation of DNA-loaded MCM double hexamers by the Dbf4-dependent kinase	32
Structural basis of MALAT1 RNA maturation and mascRNA biogenesis	31
Molting mitochondria	31
De novo design of tyrosine and serine kinase-driven protein switches	31
Structural insights into the iron nitrogenase complex	31
Remodeling of maternal mRNA through poly(A) tail orchestrates human oocyte-to-embryo transition	31
Structure of RAS signaling regulator complex reveals mechanism	30
PARP1 and HPF1 team up to flag down DNA-repair machinery	30
Structure and function of a broad-range thermal receptor in myriapods	30
A chromatin mesh model for compaction of chromatin by PRC1 in condensates	30
Looking back at 30 years of Nature Structural & Molecular Biology	30
Parkinson’s disease risk protein TMEM175 keeps lysosomes running on a proton leak	30
A tweak and a peek: How Cas9 pries open double-stranded DNA to check its sequence	30
Cryo-EM structure of the human CST–Polα/primase complex in a recruitment state	29
The structure of the NuA4–Tip60 complex reveals the mechanism and importance of long-range chromatin modification	29
De novo design of obligate ABC-type heterotrimeric proteins	29
Mechanical disengagement of the cohesin ring	29
Structural insights into TRPV2 modulation by probenecid	28
Structural basis of pH-dependent activation in a CLC transporter	28
Time-course remodeling and pathology intervention of α-synuclein amyloid fibril by heparin and heparin-like oligosaccharides	28
Catalytic and noncatalytic functions of DNA polymerase κ in translesion DNA synthesis	28
Author Correction: Phase separation drives the self-assembly of mitochondrial nucleoids for transcriptional modulation	28
Conformational coupling of redox-driven Na+-translocation in Vibrio cholerae NADH:quinone oxidoreductase	28
The yeast genome is globally accessible in living cells	28
Author Correction: The active site of O-GlcNAc transferase imposes constraints on substrate sequence	28
Molecular basis of the TRAP complex function in ER protein biogenesis	28
Distinct tau filament folds in human MAPT mutants P301L and P301T	28

Cryo-EM structure of the human MT1–Gi signaling complex	28
A rare genetic variant biases maternal meiotic recombination toward risk of pregnancy loss	27
Actin up: shifting chromosomes toward repair, but also translocations	27
Menopause age and cancer risk is influenced by rare genetic variants	27
Author Correction: Structural basis for antibody-mediated NMDA receptor clustering and endocytosis in autoimmune encephalitis	27
Fatty acid transporter MFSD2A is a multifunctional gatekeeper in brain and placenta	27
Author Correction: Smc5/6 silences episomal transcription by a three-step function	27
Replication licensing during S phase: breaking the law to prevent breaking DNA	27
A PRE loop at the dac locus acts as a topological chromatin structure that restricts and specifies enhancer–promoter communication	26
Structural insights into the regulation of Cas7-11 by TPR-CHAT	26
Mechanism of mammalian transcriptional repression by noncoding RNA	26
Combinatorial quantification of 5mC and 5hmC at individual CpG dyads and the transcriptome in single cells reveals modulators of DNA methylation maintenance fidelity	26
CRISPR–ChIP reveals selective regulation of H3K79me2 by Menin in MLL leukemia	25
Concerted SUMO-targeted ubiquitin ligase activities of TOPORS and RNF4 are essential for stress management and cell proliferation	25
True-atomic-resolution insights into the structure and functional role of linear chains and low-barrier hydrogen bonds in proteins	25
Structural inventory of cotranslational protein folding by the eukaryotic RAC complex	25
Genome dilution by cell growth drives starvation-like proteome remodeling in mammalian and yeast cells	25
Cryo-EM structures of the Spo11 core complex bound to DNA	25
The subcortical maternal complex safeguards mouse oocyte-to-embryo transition by preventing nuclear entry of SPIN1	25
Towards a structurally resolved human protein interaction network	24
Molecular basis for the regulation of human glycogen synthase by phosphorylation and glucose-6-phosphate	24
Tau filaments with the Alzheimer fold in human MAPT mutants V337M and R406W	24
Mapping the conformational landscape of the stimulatory heterotrimeric G protein	24
Cryo-EM reveals how Hsp90 and FKBP immunophilins co-regulate the glucocorticoid receptor	24
H4K16ac activates the transcription of transposable elements and contributes to their cis-regulatory function	24
Tubulin acetyltransferases access and modify the microtubule luminal K40 residue through anchors in taxane-binding pockets	24
Wide-ranging cellular functions of ion channels and lipid scramblases in the structurally related TMC, TMEM16 and TMEM63 families	24
Mechanism and modeling of human disease-associated near-exon intronic variants that perturb RNA splicing	24
The structure of the human 80S ribosome at 1.9 Å resolution reveals the molecular role of chemical modifications and ions in RNA	24
Building a molecular rotor	23
Resistance of estrogen receptor function to BET bromodomain inhibition is mediated by transcriptional coactivator cooperativity	23
Molecular basis for Gβγ-mediated activation of phosphoinositide 3-kinase γ	23
Fatty acid elongation by ELOVL condensing enzymes depends on a histidine nucleophile	23
Effect of SARS-CoV-2 B.1.1.7 mutations on spike protein structure and function	23
A unifying model for membrane protein biogenesis	23
An egg-ceptional mechanism of acentrosomal spindle assembly	23
Space exploration: finding new protein conformations using AlphaFold2	23
Structure reveals why genome folding is necessary for site-specific integration of foreign DNA into CRISPR arrays	23
Structural insights into SV2A and the mechanism of racetam anticonvulsants	23
MAVS deSUMOylation by SENP1 inhibits its aggregation and antagonizes IRF3 activation	23
Exposing chromothripsis	23
How one molecule senses light and temperature	23
Structures of complete extracellular receptor assemblies mediated by IL-12 and IL-23	23
Short poly(A) tails are protected from deadenylation by the LARP1–PABP complex	23
Structural basis for CaVα2δ:gabapentin binding	23
Structure of the γ-tubulin ring complex-capped microtubule	23
PIEZOs in vacuoles	22
Ebola virus L–VP35 structure	22
From atoms to cells	22
Human primase hangs on the primer–template and Polα to facilitate primer termination	22
A conformational switch controlling the toxicity of the prion protein	22
Plasticity in ligand recognition at somatostatin receptors	22
Natural selection finds a way, even under heavy constraints	22
mSWI/SNF promotes Polycomb repression both directly and through genome-wide redistribution	22
Visualizing the repair of broken DNA in living cells reveals a new mechanism for DNA homology search	22
Insights into stoichiometry and gating of heteromeric LRRC8A–LRRC8C volume-regulated anion channels	21
A fine balancing act: how epitranscriptome regulates dosage compensation in mammals	21
Efficient selenium use by PRDX6 suppresses iron toxicity and ferroptosis	21
Initiation of ERAD by the bifunctional complex of Mnl1/Htm1 mannosidase and protein disulfide isomerase	21
Cracking the case of m7G modification in human tRNAs	21
Building up complexity in structural biology studies	21
Future opportunities in solute carrier structural biology	20
The LexA–RecA* structure reveals a cryptic lock-and-key mechanism for SOS activation	20
Structural basis of the alkaline pH-dependent activation of insulin receptor-related receptor	20
Decoupling of degradation from deadenylation reshapes poly(A) tail length in yeast meiosis	20
Reciprocal stabilization of CtBP and TRIM28 represses autophagy to promote metastasis	20
Essential protein P116 extracts cholesterol and other indispensable lipids for Mycoplasmas	20
Author Correction: mRNA structural dynamics shape Argonaute-target interactions	20
Architecture of the ESCPE-1 membrane coat	20
Structural and functional mechanisms of anti-NMDAR autoimmune encephalitis	20
DNA methyltransferases 3A and 3B target specific sequences during mouse gastrulation	20
Structural and mechanistic insights into Streptococcus pneumoniae NADPH oxidase	20
Molecular glues that inhibit deubiquitylase activity and inflammatory signaling	20
Structural basis of meiotic chromosome synaptic elongation through hierarchical fibrous assembly of SYCE2-TEX12	20
Structural basis of LRPPRC–SLIRP-dependent translation by the mitoribosome	20
Structure of the preholoproteasome reveals late steps in proteasome core particle biogenesis	20
Could AlphaFold revolutionize chemical therapeutics?	20
The HMCES DNA-protein cross-link functions as an intermediate in DNA interstrand cross-link repair	20
ELL3 regulates spindle assembly to prevent maternally inherited aneuploidy and infertility	19
Cytoskeleton organizes nucleus	19
The RNA world	19
Looking back at 2023	19
African ancestry neurodegeneration risk variant disrupts an intronic branchpoint in GBA1	19
The essential functions of protein SUMOylation in cell proliferation	19
Structural basis of the histone ubiquitination read–write mechanism of RYBP–PRC1	19
Three-dimensional genome organization via triplex-forming RNAs	19
An in vivo platform to screen for regulators of Huntington’s disease	19
The impact of DNA methylation on CTCF-mediated 3D genome organization	19
AlphaFold3 takes a step toward decoding molecular behavior and biological computation	19
Membrane-embedded machines	19