Nature Structural & Molecular Biology

Article	Citations
Publisher Correction: Structure and activation of the RING E3 ubiquitin ligase TRIM72 on the membrane	595
Structural insights into metazoan pretargeting GET complexes	448
Author Correction: Polλ promotes microhomology-mediated end-joining	294
Celebrating Nature Structural & Molecular Biology’s 30th anniversary	275
ACAD10 and ACAD11 enable mammalian 4-hydroxy acid lipid catabolism	215
P-type ATPase magnesium transporter MgtA acts as a dimer	190
30 years of structural and molecular biology and counting	138
A novel class of inhibitors that disrupts the stability of integrin heterodimers identified by CRISPR-tiling-instructed genetic screens	129
Alternative splicing of CARM1 regulated by LincGET-guided paraspeckles biases the first cell fate in mammalian early embryos	129
The Ruminococcus bromii amylosome protein Sas6 binds single and double helical α-glucan structures in starch	128
A heterotrimeric protein complex assembles the metazoan V-ATPase upon dissipation of proton gradients	120
Isoform-resolved mRNA profiling of ribosome load defines interplay of HIF and mTOR dysregulation in kidney cancer	118
Accessible technology for diploid high-order 3D human genome analysis	118
Author Correction: Structure of the human K2P13.1 channel reveals a hydrophilic pore restriction and lipid cofactor site	97
Ensemble cryo-EM reveals conformational states of the nsp13 helicase in the SARS-CoV-2 helicase replication–transcription complex	94
A PKA inhibitor motif within SMOOTHENED controls Hedgehog signal transduction	87
Structural basis of tRNA recognition by the m3C RNA methyltransferase METTL6 in complex with SerRS seryl-tRNA synthetase	86
Structural insights into translocation and tailored synthesis of hyaluronan	85
Protein import into mitochondria — a new path through the membranes	82
Structure of the HCV glycoprotein	82
Exploration of novel αβ-protein folds through de novo design	81
Surviving under stress conditions	80
Shifting our perspective on orphan G protein-coupled receptors	77
TRIM37 prevents ectopic spindle pole assembly by peptide motif recognition and substrate-dependent oligomerization	77
Structural basis for pre-tRNA recognition and processing by the human tRNA splicing endonuclease complex	76

Cryo-EM analysis of complement C3 reveals a reversible major opening of the macroglobulin ring	75
Dissecting the mechanism of CRISPR–Cas technologies to design efficient biotechnologies	74
Transcription directionality is licensed by Integrator at active human promoters	73
Tau modification by the norepinephrine metabolite DOPEGAL stimulates its pathology and propagation	73
Snapshots of actin and tubulin folding inside the TRiC chaperonin	72
PARylated PDHE1α generates acetyl-CoA for local chromatin acetylation and DNA damage repair	72
Structures of aberrant spliceosome intermediates on their way to disassembly	71
Endocrine resistance and breast cancer plasticity are controlled by CoREST	69
Structural basis of branching during RNA splicing	68
Tropomyosin 1-I/C coordinates kinesin-1 and dynein motors during oskar mRNA transport	68
Constitutive activation mechanism of a class C GPCR	67
Uncovering protein glycosylation dynamics and heterogeneity using deep quantitative glycoprofiling (DQGlyco)	63
Reduction of DHHC5-mediated beclin 1 S-palmitoylation underlies autophagy decline in aging	62
Current challenges in understanding the role of enhancers in disease	60
Studying the impact of the nuclear topography on gene function	59
Binding NEMO: Liquid–liquid phase separation captures immune regulator	58
Nature, more than nurture, of epigenetic states	58
Author Correction: Structural basis of tRNA recognition by the m3C RNA methyltransferase METTL6 in complex with SerRS seryl-tRNA synthetase	57
THEMIS is a substrate and allosteric activator of SHP1, playing dual roles during T cell development	57
Transcription start site choice diversifies mRNA isoforms and defines cancer cell behavior	57
Structures of outer-arm dynein array on microtubule doublet reveal a motor coordination mechanism	56
The conformational landscape of human transthyretin revealed by cryo-EM	55
Comprehensive analysis of Saccharomyces cerevisiae intron structures in vivo	55
DNA methylation restricts coordinated germline and neural fates in embryonic stem cell differentiation	54
Lineage regulators TFAP2C and NR5A2 function as bipotency activators in totipotent embryos	54
Cryogenic electron microscopy structures reveal how ATP and DNA binding in MutS coordinates sequential steps of DNA mismatch repair	54
Building insights into KRAS signaling complexes	53
Author Correction: Cryo-EM structure of an active central apparatus	53
A personal perspective of the voltage-gated potassium channel studies	52
Autoinhibition of a clamp-loader ATPase revealed by deep mutagenesis and cryo-EM	52
Chemical modifications, ions and water molecules in the sub-2 Å resolution structure of the human 80S ribosome	51
Cryo-EM structure of the NDH–PSI–LHCI supercomplex from Spinacia oleracea	51
Cohesin closes the door on coexpression	51
Better SIFI than sorry	50
Smc5/6 silences episomal transcription by a three-step function	50
cBAF generates subnucleosomes that expand OCT4 binding and function beyond DNA motifs at enhancers	50
SCAF1 drives the compositional diversity of mammalian respirasomes	50
Signal-induced enhancer activation requires Ku70 to read topoisomerase1–DNA covalent complexes	49
Transcriptional repression upon S phase entry protects genome integrity in pluripotent cells	48
Understanding ubiquitination in neurodevelopment by integrating insights across space and time	48
Deadenylation kinetics of mixed poly(A) tails at single-nucleotide resolution	48
Control of transcription elongation and DNA repair by alarmone ppGpp	47
EGOC inhibits TOROID polymerization by structurally activating TORC1	47
A conserved coupling of transcriptional ON and OFF periods underlies bursting dynamics	47
Telomeric 8-oxo-guanine drives rapid premature senescence in the absence of telomere shortening	46
Phase separation drives X-chromosome inactivation	46
Structures of transcription preinitiation complex engaged with the +1 nucleosome	46
Dynamic PRC1–CBX8 stabilizes a porous structure of chromatin condensates	46
Cryo-EM structure of an active central apparatus	45
Structure of adenylyl cyclase 5 in complex with Gβγ offers insights into ADCY5-related dyskinesia	45

Transcription modulates chromatin dynamics and locus configuration sampling	44
Perfect match: PET ligand fits snugly into folded Tau filaments	44
Structure and activation of the human autophagy-initiating ULK1C:PI3KC3-C1 supercomplex	44
Rhodopsin-bestrophin fusion proteins from unicellular algae form gigantic pentameric ion channels	44
The complexin C-terminal amphipathic helix stabilizes the fusion pore open state by sculpting membranes	44
MiOS, an integrated imaging and computational strategy to model gene folding with nucleosome resolution	44
Structural basis for the dynamic chaperoning of disordered clients by Hsp90	44
Architects of the membrane: structures of eukaryotic choline phosphotransferase 1 and choline/ethanolamine phosphotransferase 1	44
Microtubule-binding-induced allostery triggers LIS1 dissociation from dynein prior to cargo transport	44
The coupling mechanism of mammalian mitochondrial complex I	43
Pioneer factor Pax7 initiates two-step cell-cycle-dependent chromatin opening	43
Excited-state observation of active K-Ras reveals differential structural dynamics of wild-type versus oncogenic G12D and G12C mutants	43
Molecular interactions contributing to FUS SYGQ LC-RGG phase separation and co-partitioning with RNA polymerase II heptads	41
Structure and interactions of the endogenous human Commander complex	41
Functional epigenomics: chromatin complexity untangled	41
Na+-V-ATPase inhibitor curbs VRE growth and unveils Na+ pathway structure	41
Start codon-associated ribosomal frameshifting mediates nutrient stress adaptation	41
Thirty years of structural changes	40
Diverse activation mechanisms of PI3Ks	40
Transcription and replication meet the silent X chromosome territory	40
Virtual screen raises hit rate	40
All roads lead to MRN regulation at telomeres: different paths to one solution	40
STING to the lysosome’s rescue	39
Finding and recycling stalled spliceosomes	39
TALEDs complete the toolkit for editing human mitochondrial DNA	38
Structural plasticity of bacterial ESCRT-III protein PspA in higher-order assemblies	38
Condensation of ZFP207 and U1 snRNP promotes spliceosome assembly	38
Transport mechanism of presynaptic high-affinity choline uptake by CHT1	38
ZBTB16/PLZF regulates juvenile spermatogonial stem cell development through an extensive transcription factor poising network	37
Guidelines for minimal reporting requirements, design and interpretation of experiments involving the use of eukaryotic dual gene expression reporters (MINDR)	37
Mechanistic basis for PYROXD1-mediated protection of the human tRNA ligase complex against oxidative inactivation	37
Structural basis of hepatitis B virus receptor binding	37
Evolution of a histone variant involved in compartmental regulation of NAD metabolism	37
Cryptic elements of the heat-shock response	36
MacroH2A1.1 has evolved to let PARP1 do more by loosening its grip on PAR	36
Structural basis of circularly permuted group II intron self-splicing	36
Hallucination of closed repeat proteins containing central pockets	36
DNA replication at high res	36
CENP-N promotes the compaction of centromeric chromatin	36
RNA polymerase II depletion from the inactive X chromosome territory is not mediated by physical compartmentalization	36
Mitoribosome assembly comes into view	36
Looking back at 2021	36
Structure and function of the human mitochondrial MRS2 channel	36
A PAR6–aPKC–LGL structure reveals how LGL antagonizes aPKC	35
Regulatory activity is the default DNA state in eukaryotes	35
Structural clues about bridge-mediated lipid transfer	34
Mesoscale regulation of microtubule-organizing centers by the E3 ligase TRIM37	34
High-resolution structures of the SARS-CoV-2 N7-methyltransferase inform therapeutic development	34
Orchestrating nucleic acid–protein interactions at chromosome ends: telomerase mechanisms come into focus	34
Heritable maintenance of chromatin modifications confers transcriptional memory of interferon-γ signaling	34
De novo design of tyrosine and serine kinase-driven protein switches	33
Molecular basis of human ATM kinase inhibition	33
Cooperation of chromatin remodeling SWI/SNF complex and pioneer factor AP-1 shapes 3D enhancer landscapes	33
Structural mechanism for the selective phosphorylation of DNA-loaded MCM double hexamers by the Dbf4-dependent kinase	33
cGAMP-activated cGAS–STING signaling: its bacterial origins and evolutionary adaptation by metazoans	33
Structural insights into the decoding capability of isoleucine tRNAs with lysidine and agmatidine	33
Cryo-EM structures of human RNA polymerase I	32
Structural basis of MALAT1 RNA maturation and mascRNA biogenesis	32
Remodeling of maternal mRNA through poly(A) tail orchestrates human oocyte-to-embryo transition	32
Structural insights into the iron nitrogenase complex	32
A chromatin mesh model for compaction of chromatin by PRC1 in condensates	31
Structure of a volume-regulated heteromeric LRRC8A/C channel	31
Structure of RAS signaling regulator complex reveals mechanism	31
Molting mitochondria	31
Mechanical disengagement of the cohesin ring	30
Cryo-EM structure of the human CST–Polα/primase complex in a recruitment state	30
Looking back at 30 years of Nature Structural & Molecular Biology	30
A nanobody-based therapeutic targeting Nipah virus limits viral escape	30
A tweak and a peek: How Cas9 pries open double-stranded DNA to check its sequence	30
Cryo-EM structure of the human MT1–Gi signaling complex	30
De novo design of obligate ABC-type heterotrimeric proteins	29
PARP1 and HPF1 team up to flag down DNA-repair machinery	29
The structure of the NuA4–Tip60 complex reveals the mechanism and importance of long-range chromatin modification	29
Mechanisms for licensing origins of DNA replication in eukaryotic cells	29
Remote on–off switching of protein activity by intrinsically disordered region	29
Distinct tau filament folds in human MAPT mutants P301L and P301T	29
Ferlin structures	29
Glycerol mediates crosstalk between metabolism and trafficking through the golgin Imh1	29
Conformational coupling of redox-driven Na+-translocation in Vibrio cholerae NADH:quinone oxidoreductase	28
Parkinson’s disease risk protein TMEM175 keeps lysosomes running on a proton leak	28

Fatty acid transporter MFSD2A is a multifunctional gatekeeper in brain and placenta	28
Catalytic and noncatalytic functions of DNA polymerase κ in translesion DNA synthesis	28
Molecular basis of the TRAP complex function in ER protein biogenesis	28
The yeast genome is globally accessible in living cells	28
Actin up: shifting chromosomes toward repair, but also translocations	28
Structure and function of a broad-range thermal receptor in myriapods	28
Structural basis of pH-dependent activation in a CLC transporter	28
Author Correction: The active site of O-GlcNAc transferase imposes constraints on substrate sequence	28
Time-course remodeling and pathology intervention of α-synuclein amyloid fibril by heparin and heparin-like oligosaccharides	28
Replication licensing during S phase: breaking the law to prevent breaking DNA	27
A rare genetic variant biases maternal meiotic recombination toward risk of pregnancy loss	27
Author Correction: Structural basis for antibody-mediated NMDA receptor clustering and endocytosis in autoimmune encephalitis	27
Mechanism of mammalian transcriptional repression by noncoding RNA	26
Author Correction: Phase separation drives the self-assembly of mitochondrial nucleoids for transcriptional modulation	26
Structural insights into TRPV2 modulation by probenecid	26
Cryo-EM structures of the Spo11 core complex bound to DNA	26
A PRE loop at the dac locus acts as a topological chromatin structure that restricts and specifies enhancer–promoter communication	26
The subcortical maternal complex safeguards mouse oocyte-to-embryo transition by preventing nuclear entry of SPIN1	26
Structural inventory of cotranslational protein folding by the eukaryotic RAC complex	26
Author Correction: Smc5/6 silences episomal transcription by a three-step function	26
Structural insights into the regulation of Cas7-11 by TPR-CHAT	26
CRISPR–ChIP reveals selective regulation of H3K79me2 by Menin in MLL leukemia	26
Tau filaments with the Alzheimer fold in human MAPT mutants V337M and R406W	26
Menopause age and cancer risk is influenced by rare genetic variants	26
Tubulin acetyltransferases access and modify the microtubule luminal K40 residue through anchors in taxane-binding pockets	25
Cryo-EM reveals how Hsp90 and FKBP immunophilins co-regulate the glucocorticoid receptor	25
Genome dilution by cell growth drives starvation-like proteome remodeling in mammalian and yeast cells	25
Mechanism and modeling of human disease-associated near-exon intronic variants that perturb RNA splicing	25
Mapping the conformational landscape of the stimulatory heterotrimeric G protein	25
True-atomic-resolution insights into the structure and functional role of linear chains and low-barrier hydrogen bonds in proteins	25
Concerted SUMO-targeted ubiquitin ligase activities of TOPORS and RNF4 are essential for stress management and cell proliferation	25
The structure of the human 80S ribosome at 1.9 Å resolution reveals the molecular role of chemical modifications and ions in RNA	25
Towards a structurally resolved human protein interaction network	25
Molecular basis for the regulation of human glycogen synthase by phosphorylation and glucose-6-phosphate	25
Wide-ranging cellular functions of ion channels and lipid scramblases in the structurally related TMC, TMEM16 and TMEM63 families	25
Combinatorial quantification of 5mC and 5hmC at individual CpG dyads and the transcriptome in single cells reveals modulators of DNA methylation maintenance fidelity	25
H4K16ac activates the transcription of transposable elements and contributes to their cis-regulatory function	25
Structural insights into SV2A and the mechanism of racetam anticonvulsants	24
An egg-ceptional mechanism of acentrosomal spindle assembly	24
Structural basis for CaVα2δ:gabapentin binding	24
Structure reveals why genome folding is necessary for site-specific integration of foreign DNA into CRISPR arrays	24
Exposing chromothripsis	24
How one molecule senses light and temperature	24
Molecular basis for Gβγ-mediated activation of phosphoinositide 3-kinase γ	24
Short poly(A) tails are protected from deadenylation by the LARP1–PABP complex	24
Building a molecular rotor	24
Space exploration: finding new protein conformations using AlphaFold2	24
A conformational switch controlling the toxicity of the prion protein	23
A unifying model for membrane protein biogenesis	23
Effect of SARS-CoV-2 B.1.1.7 mutations on spike protein structure and function	23
Ebola virus L–VP35 structure	23
The molecular basis of lamin-specific chromatin interactions	23
Neuronal VPS13D loss drives microglial activation	23
Structures of complete extracellular receptor assemblies mediated by IL-12 and IL-23	23
Resistance of estrogen receptor function to BET bromodomain inhibition is mediated by transcriptional coactivator cooperativity	23
Visualizing the repair of broken DNA in living cells reveals a new mechanism for DNA homology search	23
Structure of the γ-tubulin ring complex-capped microtubule	23
MAVS deSUMOylation by SENP1 inhibits its aggregation and antagonizes IRF3 activation	23
Plasticity in ligand recognition at somatostatin receptors	23
Human primase hangs on the primer–template and Polα to facilitate primer termination	23
From atoms to cells	22
A fine balancing act: how epitranscriptome regulates dosage compensation in mammals	22
Cracking the case of m7G modification in human tRNAs	22
Building up complexity in structural biology studies	22
PIEZOs in vacuoles	22
Efficient selenium use by PRDX6 suppresses iron toxicity and ferroptosis	22
Insights into stoichiometry and gating of heteromeric LRRC8A–LRRC8C volume-regulated anion channels	22
Structural and functional mechanisms of anti-NMDAR autoimmune encephalitis	21
Molecular glues that inhibit deubiquitylase activity and inflammatory signaling	21
Structural basis of LRPPRC–SLIRP-dependent translation by the mitoribosome	21
Decoupling of degradation from deadenylation reshapes poly(A) tail length in yeast meiosis	21
Could AlphaFold revolutionize chemical therapeutics?	21
Initiation of ERAD by the bifunctional complex of Mnl1/Htm1 mannosidase and protein disulfide isomerase	21
Structural basis of meiotic chromosome synaptic elongation through hierarchical fibrous assembly of SYCE2-TEX12	21
Structure of the preholoproteasome reveals late steps in proteasome core particle biogenesis	21
Structural basis of the alkaline pH-dependent activation of insulin receptor-related receptor	21
Reciprocal stabilization of CtBP and TRIM28 represses autophagy to promote metastasis	21
Future opportunities in solute carrier structural biology	21
Structural basis of the histone ubiquitination read–write mechanism of RYBP–PRC1	21
Natural selection finds a way, even under heavy constraints	20
Essential protein P116 extracts cholesterol and other indispensable lipids for Mycoplasmas	20
Structural and mechanistic insights into Streptococcus pneumoniae NADPH oxidase	20
The essential functions of protein SUMOylation in cell proliferation	20
The LexA–RecA* structure reveals a cryptic lock-and-key mechanism for SOS activation	20
AlphaFold3 takes a step toward decoding molecular behavior and biological computation	20
DNA methyltransferases 3A and 3B target specific sequences during mouse gastrulation	20
The HMCES DNA-protein cross-link functions as an intermediate in DNA interstrand cross-link repair	20
Architecture of the ESCPE-1 membrane coat	20
The impact of DNA methylation on CTCF-mediated 3D genome organization	20
ELL3 regulates spindle assembly to prevent maternally inherited aneuploidy and infertility	19
Higher-order phosphatase–substrate contacts terminate the integrated stress response	19
An in vivo platform to screen for regulators of Huntington’s disease	19
Structural insights into binding of therapeutic channel blockers in NMDA receptors	19
Distinct stabilization of the human T cell leukemia virus type 1 immature Gag lattice	19
Structural basis for membrane remodeling by the AP5–SPG11–SPG15 complex	19