Nature Structural & Molecular Biology

Article	Citations
Publisher Correction: Structure and activation of the RING E3 ubiquitin ligase TRIM72 on the membrane	522
Author Correction: Polλ promotes microhomology-mediated end-joining	304
Author Correction: Structure of the human K2P13.1 channel reveals a hydrophilic pore restriction and lipid cofactor site	214
Celebrating Nature Structural & Molecular Biology’s 30th anniversary	150
30 years of structural and molecular biology and counting	146
Towards a molecular and structural definition of cell death	140
Accessible technology for diploid high-order 3D human genome analysis	126
TRIM37 prevents ectopic spindle pole assembly by peptide motif recognition and substrate-dependent oligomerization	107
Surviving under stress conditions	107
The Ruminococcus bromii amylosome protein Sas6 binds single and double helical α-glucan structures in starch	99
Structure of the HCV glycoprotein	98
ACAD10 and ACAD11 enable mammalian 4-hydroxy acid lipid catabolism	94
Isoform-resolved mRNA profiling of ribosome load defines interplay of HIF and mTOR dysregulation in kidney cancer	89
Structures of aberrant spliceosome intermediates on their way to disassembly	89
Structural basis for pre-tRNA recognition and processing by the human tRNA splicing endonuclease complex	89
P-type ATPase magnesium transporter MgtA acts as a dimer	88
Constitutive activation mechanism of a class C GPCR	87
A novel class of inhibitors that disrupts the stability of integrin heterodimers identified by CRISPR-tiling-instructed genetic screens	84
Shifting our perspective on orphan G protein-coupled receptors	84
Gene regulation through exon junction complex modularity	78
Exploration of novel αβ-protein folds through de novo design	77
Current challenges in understanding the role of enhancers in disease	75
Tropomyosin 1-I/C coordinates kinesin-1 and dynein motors during oskar mRNA transport	75
Ensemble cryo-EM reveals conformational states of the nsp13 helicase in the SARS-CoV-2 helicase replication–transcription complex	74
Transcription directionality is licensed by Integrator at active human promoters	72

Cryo-EM analysis of complement C3 reveals a reversible major opening of the macroglobulin ring	71
Alternative splicing of CARM1 regulated by LincGET-guided paraspeckles biases the first cell fate in mammalian early embryos	70
Endocrine resistance and breast cancer plasticity are controlled by CoREST	70
Tau modification by the norepinephrine metabolite DOPEGAL stimulates its pathology and propagation	70
Structural basis of tRNA recognition by the m3C RNA methyltransferase METTL6 in complex with SerRS seryl-tRNA synthetase	70
Uncovering protein glycosylation dynamics and heterogeneity using deep quantitative glycoprofiling (DQGlyco)	69
Structural insights into translocation and tailored synthesis of hyaluronan	68
Dissecting the mechanism of CRISPR–Cas technologies to design efficient biotechnologies	66
Snapshots of actin and tubulin folding inside the TRiC chaperonin	66
Protein import into mitochondria — a new path through the membranes	64
Reduction of DHHC5-mediated beclin 1 S-palmitoylation underlies autophagy decline in aging	62
PARylated PDHE1α generates acetyl-CoA for local chromatin acetylation and DNA damage repair	62
A PKA inhibitor motif within SMOOTHENED controls Hedgehog signal transduction	61
A heterotrimeric protein complex assembles the metazoan V-ATPase upon dissipation of proton gradients	61
Structural basis of branching during RNA splicing	61
Binding NEMO: Liquid–liquid phase separation captures immune regulator	60
Studying the impact of the nuclear topography on gene function	60
Cohesin closes the door on coexpression	59
Author Correction: Structural basis of the histone ubiquitination read–write mechanism of RYBP–PRC1	59
Lineage regulators TFAP2C and NR5A2 function as bipotency activators in totipotent embryos	58
Author Correction: Cryo-EM structure of an active central apparatus	58
Structure and activation of the human autophagy-initiating ULK1C:PI3KC3-C1 supercomplex	58
SCAF1 drives the compositional diversity of mammalian respirasomes	57
Microtubule-binding-induced allostery triggers LIS1 dissociation from dynein prior to cargo transport	57
EGOC inhibits TOROID polymerization by structurally activating TORC1	57
DNA methylation restricts coordinated germline and neural fates in embryonic stem cell differentiation	57
Control of transcription elongation and DNA repair by alarmone ppGpp	57
Rhodopsin-bestrophin fusion proteins from unicellular algae form gigantic pentameric ion channels	56
Chemical modifications, ions and water molecules in the sub-2 Å resolution structure of the human 80S ribosome	55
Transcription start site choice diversifies mRNA isoforms and defines cancer cell behavior	55
Phase separation drives X-chromosome inactivation	55
A personal perspective of the voltage-gated potassium channel studies	55
Better SIFI than sorry	55
THEMIS is a substrate and allosteric activator of SHP1, playing dual roles during T cell development	55
Understanding ubiquitination in neurodevelopment by integrating insights across space and time	54
MiOS, an integrated imaging and computational strategy to model gene folding with nucleosome resolution	52
cBAF generates subnucleosomes that expand OCT4 binding and function beyond DNA motifs at enhancers	52
Smc5/6 silences episomal transcription by a three-step function	51
Signal-induced enhancer activation requires Ku70 to read topoisomerase1–DNA covalent complexes	51
A conserved coupling of transcriptional ON and OFF periods underlies bursting dynamics	51
Author Correction: Structural basis of tRNA recognition by the m3C RNA methyltransferase METTL6 in complex with SerRS seryl-tRNA synthetase	51
Deadenylation kinetics of mixed poly(A) tails at single-nucleotide resolution	51
Cryo-EM structure of the NDH–PSI–LHCI supercomplex from Spinacia oleracea	51
Addendum: Retinoic acid signaling is critical during the totipotency window in early mammalian development	51
Autoinhibition of a clamp-loader ATPase revealed by deep mutagenesis and cryo-EM	51
Dynamic PRC1–CBX8 stabilizes a porous structure of chromatin condensates	50
The conformational landscape of human transthyretin revealed by cryo-EM	50
Structures of transcription preinitiation complex engaged with the +1 nucleosome	49
Transcriptional repression upon S phase entry protects genome integrity in pluripotent cells	49
Telomeric 8-oxo-guanine drives rapid premature senescence in the absence of telomere shortening	48

Cryogenic electron microscopy structures reveal how ATP and DNA binding in MutS coordinates sequential steps of DNA mismatch repair	48
Comprehensive analysis of Saccharomyces cerevisiae intron structures in vivo	47
Structure of adenylyl cyclase 5 in complex with Gβγ offers insights into ADCY5-related dyskinesia	47
Cryo-EM structure of an active central apparatus	47
Perfect match: PET ligand fits snugly into folded Tau filaments	46
Virtual screen raises hit rate	46
Thirty years of structural changes	45
Transcription and replication meet the silent X chromosome territory	45
Mechanistic basis for PYROXD1-mediated protection of the human tRNA ligase complex against oxidative inactivation	45
All roads lead to MRN regulation at telomeres: different paths to one solution	45
STING to the lysosome’s rescue	44
TALEDs complete the toolkit for editing human mitochondrial DNA	44
The complexin C-terminal amphipathic helix stabilizes the fusion pore open state by sculpting membranes	43
Functional epigenomics: chromatin complexity untangled	43
ZBTB16/PLZF regulates juvenile spermatogonial stem cell development through an extensive transcription factor poising network	43
Structural basis for the dynamic chaperoning of disordered clients by Hsp90	43
Finding and recycling stalled spliceosomes	43
Structural basis of circularly permuted group II intron self-splicing	43
Na+-V-ATPase inhibitor curbs VRE growth and unveils Na+ pathway structure	42
Pioneer factor Pax7 initiates two-step cell-cycle-dependent chromatin opening	42
RNA polymerase II depletion from the inactive X chromosome territory is not mediated by physical compartmentalization	42
Structure and function of the human mitochondrial MRS2 channel	42
Transport mechanism of presynaptic high-affinity choline uptake by CHT1	41
Structural plasticity of bacterial ESCRT-III protein PspA in higher-order assemblies	41
Transcription modulates chromatin dynamics and locus configuration sampling	41
Guidelines for minimal reporting requirements, design and interpretation of experiments involving the use of eukaryotic dual gene expression reporters (MINDR)	40
Structural basis of hepatitis B virus receptor binding	40
Architects of the membrane: structures of eukaryotic choline phosphotransferase 1 and choline/ethanolamine phosphotransferase 1	39
CENP-N promotes the compaction of centromeric chromatin	39
Dynamics of microcompartment formation at the mitosis-to-G1 transition	38
DNA replication at high res	38
Condensation of ZFP207 and U1 snRNP promotes spliceosome assembly	38
Structure and interactions of the endogenous human Commander complex	38
Diverse activation mechanisms of PI3Ks	38
Start codon-associated ribosomal frameshifting mediates nutrient stress adaptation	38
The coupling mechanism of mammalian mitochondrial complex I	38
Excited-state observation of active K-Ras reveals differential structural dynamics of wild-type versus oncogenic G12D and G12C mutants	38
Orchestrating nucleic acid–protein interactions at chromosome ends: telomerase mechanisms come into focus	37
A PAR6–aPKC–LGL structure reveals how LGL antagonizes aPKC	37
Mesoscale regulation of microtubule-organizing centers by the E3 ligase TRIM37	37
Cryptic elements of the heat-shock response	37
Structural insights into the iron nitrogenase complex	37
Structural clues about bridge-mediated lipid transfer	37
Heritable maintenance of chromatin modifications confers transcriptional memory of interferon-γ signaling	36
Two dynamically competing factors determine the translation start site	36
Structural insights into the decoding capability of isoleucine tRNAs with lysidine and agmatidine	36
Regulatory activity is the default DNA state in eukaryotes	36
cGAMP-activated cGAS–STING signaling: its bacterial origins and evolutionary adaptation by metazoans	35
Structure of a volume-regulated heteromeric LRRC8A/C channel	35
Structural basis of MALAT1 RNA maturation and mascRNA biogenesis	35
High-resolution structures of the SARS-CoV-2 N7-methyltransferase inform therapeutic development	35
Remodeling of maternal mRNA through poly(A) tail orchestrates human oocyte-to-embryo transition	35
Cooperation of chromatin remodeling SWI/SNF complex and pioneer factor AP-1 shapes 3D enhancer landscapes	35
Looking back at 30 years of Nature Structural & Molecular Biology	34
Hallucination of closed repeat proteins containing central pockets	34
Structure of RAS signaling regulator complex reveals mechanism	34
A chromatin mesh model for compaction of chromatin by PRC1 in condensates	34
Molting mitochondria	34
Ferlin structures	33
A tweak and a peek: How Cas9 pries open double-stranded DNA to check its sequence	33
Catalytic and noncatalytic functions of DNA polymerase κ in translesion DNA synthesis	33
PARP1 and HPF1 team up to flag down DNA-repair machinery	33
Time-course remodeling and pathology intervention of α-synuclein amyloid fibril by heparin and heparin-like oligosaccharides	32
Structural basis of pH-dependent activation in a CLC transporter	32
Mechanisms for licensing origins of DNA replication in eukaryotic cells	32
Mechanical disengagement of the cohesin ring	32
Molecular basis of the TRAP complex function in ER protein biogenesis	32
De novo design of obligate ABC-type heterotrimeric proteins	32
Cryo-EM structure of the human CST–Polα/primase complex in a recruitment state	32
EMProt improves structure determination from cryo-EM maps	32
Parkinson’s disease risk protein TMEM175 keeps lysosomes running on a proton leak	32
Glycerol mediates crosstalk between metabolism and trafficking through the golgin Imh1	31
Conformational coupling of redox-driven Na+-translocation in Vibrio cholerae NADH:quinone oxidoreductase	31
Author Correction: The active site of O-GlcNAc transferase imposes constraints on substrate sequence	31
The structure of the NuA4–Tip60 complex reveals the mechanism and importance of long-range chromatin modification	31
Structure and function of a broad-range thermal receptor in myriapods	31
Remote on–off switching of protein activity by intrinsically disordered region	31
Author Correction: Smc5/6 silences episomal transcription by a three-step function	31
A nanobody-based therapeutic targeting Nipah virus limits viral escape	31
The yeast genome is globally accessible in living cells	31

Distinct tau filament folds in human MAPT mutants P301L and P301T	31
A rare genetic variant biases maternal meiotic recombination toward risk of pregnancy loss	31
Menopause age and cancer risk is influenced by rare genetic variants	30
Author Correction: Structural basis for antibody-mediated NMDA receptor clustering and endocytosis in autoimmune encephalitis	30
TMEM170 proteins are lipid scramblases associated with bridge-type lipid transporters BLTP1/Csf1	30
CRISPR–ChIP reveals selective regulation of H3K79me2 by Menin in MLL leukemia	30
Actin up: shifting chromosomes toward repair, but also translocations	30
Returning home to navigate challenges and meet potential in Poland	30
Kinetic control of mammalian transcription elongation	30
Replication licensing during S phase: breaking the law to prevent breaking DNA	30
Fatty acid transporter MFSD2A is a multifunctional gatekeeper in brain and placenta	30
Mechanism of mammalian transcriptional repression by noncoding RNA	30
A PRE loop at the dac locus acts as a topological chromatin structure that restricts and specifies enhancer–promoter communication	29
Mechanism and modeling of human disease-associated near-exon intronic variants that perturb RNA splicing	29
Cryo-EM structures of the Spo11 core complex bound to DNA	29
Molecular basis for the regulation of human glycogen synthase by phosphorylation and glucose-6-phosphate	29
Regulation of kinesin-2 motility by its β-hairpin motif	29
Combinatorial quantification of 5mC and 5hmC at individual CpG dyads and the transcriptome in single cells reveals modulators of DNA methylation maintenance fidelity	29
True-atomic-resolution insights into the structure and functional role of linear chains and low-barrier hydrogen bonds in proteins	29
The subcortical maternal complex safeguards mouse oocyte-to-embryo transition by preventing nuclear entry of SPIN1	29
Structural inventory of cotranslational protein folding by the eukaryotic RAC complex	28
The structure of the human 80S ribosome at 1.9 Å resolution reveals the molecular role of chemical modifications and ions in RNA	28
Concerted SUMO-targeted ubiquitin ligase activities of TOPORS and RNF4 are essential for stress management and cell proliferation	28
Genome dilution by cell growth drives starvation-like proteome remodeling in mammalian and yeast cells	28
Cryo-EM reveals how Hsp90 and FKBP immunophilins co-regulate the glucocorticoid receptor	28
Structural insights into TRPV2 modulation by probenecid	28
Tubulin acetyltransferases access and modify the microtubule luminal K40 residue through anchors in taxane-binding pockets	28
Mapping the conformational landscape of the stimulatory heterotrimeric G protein	28
Structural insights into the regulation of Cas7-11 by TPR-CHAT	28
H4K16ac activates the transcription of transposable elements and contributes to their cis-regulatory function	28
Towards a structurally resolved human protein interaction network	28
Wide-ranging cellular functions of ion channels and lipid scramblases in the structurally related TMC, TMEM16 and TMEM63 families	28
How one molecule senses light and temperature	27
Structures of complete extracellular receptor assemblies mediated by IL-12 and IL-23	27
Tau filaments with the Alzheimer fold in human MAPT mutants V337M and R406W	27
Building a molecular rotor	27
An egg-ceptional mechanism of acentrosomal spindle assembly	27
Exposing chromothripsis	27
Structural landscape of activation, desensitization and inhibition in the human TRPM4 channel	27
Computational design of sequence-specific DNA-binding proteins	26
Plasticity in ligand recognition at somatostatin receptors	26
Structural insights into SV2A and the mechanism of racetam anticonvulsants	26
Short poly(A) tails are protected from deadenylation by the LARP1–PABP complex	26
Molecular basis for Gβγ-mediated activation of phosphoinositide 3-kinase γ	26
Neuronal VPS13D loss drives microglial activation	26
Structural basis for CaVα2δ:gabapentin binding	26
Space exploration: finding new protein conformations using AlphaFold2	26
Resistance of estrogen receptor function to BET bromodomain inhibition is mediated by transcriptional coactivator cooperativity	25
Visualizing the repair of broken DNA in living cells reveals a new mechanism for DNA homology search	25
Structure reveals why genome folding is necessary for site-specific integration of foreign DNA into CRISPR arrays	25
MAVS deSUMOylation by SENP1 inhibits its aggregation and antagonizes IRF3 activation	25
From atoms to cells	25
A unifying model for membrane protein biogenesis	25
The molecular basis of lamin-specific chromatin interactions	25
A conformational switch controlling the toxicity of the prion protein	25
Human primase hangs on the primer–template and Polα to facilitate primer termination	25
Structural basis for retron co-option of anti-phage ATPase-nuclease	25
Structure of the γ-tubulin ring complex-capped microtubule	25
Cracking the case of m7G modification in human tRNAs	24
Building up complexity in structural biology studies	24
A snapshot of proteostasis in human oocytes	24
The LexA–RecA* structure reveals a cryptic lock-and-key mechanism for SOS activation	24
Efficient selenium use by PRDX6 suppresses iron toxicity and ferroptosis	24
Insights into stoichiometry and gating of heteromeric LRRC8A–LRRC8C volume-regulated anion channels	24
Reciprocal stabilization of CtBP and TRIM28 represses autophagy to promote metastasis	24
Natural selection finds a way, even under heavy constraints	24
DNA methyltransferases 3A and 3B target specific sequences during mouse gastrulation	24
Ebola virus L–VP35 structure	24
A fine balancing act: how epitranscriptome regulates dosage compensation in mammals	24
Structural and mechanistic insights into Streptococcus pneumoniae NADPH oxidase	24
Molecular glues that inhibit deubiquitylase activity and inflammatory signaling	24
Structural basis of the alkaline pH-dependent activation of insulin receptor-related receptor	23
Initiation of ERAD by the bifunctional complex of Mnl1/Htm1 mannosidase and protein disulfide isomerase	23
Essential protein P116 extracts cholesterol and other indispensable lipids for Mycoplasmas	23
Structural basis of LRPPRC–SLIRP-dependent translation by the mitoribosome	23
Structural and functional mechanisms of anti-NMDAR autoimmune encephalitis	23
Closing 2025, and a look ahead	23
Structural basis of the histone ubiquitination read–write mechanism of RYBP–PRC1	23
AlphaFold3 takes a step toward decoding molecular behavior and biological computation	23
The impact of DNA methylation on CTCF-mediated 3D genome organization	23
Caught in the act: how a brake on cell growth is anchored to lysosomes	23
Architecture of the ESCPE-1 membrane coat	23
Structure of the preholoproteasome reveals late steps in proteasome core particle biogenesis	23
Future opportunities in solute carrier structural biology	23
The essential functions of protein SUMOylation in cell proliferation	22
ELL3 regulates spindle assembly to prevent maternally inherited aneuploidy and infertility	22
The HMCES DNA-protein cross-link functions as an intermediate in DNA interstrand cross-link repair	22
Membrane-embedded machines	22
Looking back at 2023	22
The RNA world	22
An in vivo platform to screen for regulators of Huntington’s disease	22
The rise of ADP-ribose–ubiquitin	21
Structure of the decoy module of human glycoprotein 2 and uromodulin and its interaction with bacterial adhesin FimH	21
Filament formation and NAD processing by noncanonical human FAM118 sirtuins	21
A small molecule stabilizer rescues the surface expression of nearly all missense variants in a GPCR	21