Nature Structural & Molecular Biology

Article	Citations
Target practice: first Piwi structure with RNA	555
Aging RNA Polymerase II may speed recklessly	397
The activated inflammasome	270
Musings on art and science	256
LiBERating PARP1	200
Cryo-EM analysis of complement C3 reveals a reversible major opening of the macroglobulin ring	185
Building a molecular rotor	170
Networking counters stress	166
Readout of histone methylation by Trim24 locally restricts chromatin opening by p53	158
Structural basis of tRNA recognition by the m3C RNA methyltransferase METTL6 in complex with SerRS seryl-tRNA synthetase	140
Multivalent interactions of the disordered regions of XLF and XRCC4 foster robust cellular NHEJ and drive the formation of ligation-boosting condensates in vitro	134
VCP/p97-associated proteins are binders and debranching enzymes of K48–K63-branched ubiquitin chains	117
MAVS deSUMOylation by SENP1 inhibits its aggregation and antagonizes IRF3 activation	117
Embracing change	116
Structure of the HCV glycoprotein	113
Structure of the γ-tubulin ring complex-capped microtubule	112
Molecular basis of Gabija anti-phage supramolecular assemblies	112
An egg-ceptional mechanism of acentrosomal spindle assembly	105
How one molecule senses light and temperature	105
Two rings to fold them	104
Cryo-EM for protein discovery	82
Celebrating Nature Structural & Molecular Biology’s 30th anniversary	80
Structural basis of branching during RNA splicing	77
Dissecting the mechanism of CRISPR–Cas technologies to design efficient biotechnologies	76
Conformational changes in heat- and proton-sensing ion channel in centipedes	74

Computational design of non-porous pH-responsive antibody nanoparticles	74
Multidomain interactions and ring opening of the p97 ATPase by the UBXD1 adapter	73
Space exploration: finding new protein conformations using AlphaFold2	73
Atomic ribosome activity	72
Exposing chromothripsis	71
A structural model of a Ras–Raf signalosome	70
The inner nuclear membrane protein Lem2 coordinates RNA degradation at the nuclear periphery	70
Structural basis for pre-tRNA recognition and processing by the human tRNA splicing endonuclease complex	70
ARF GTPases activate Salmonella effector SopF to ADP-ribosylate host V-ATPase and inhibit endomembrane damage-induced autophagy	70
Single-cell joint analysis of gene expression and histone modifications in droplets	69
Tagging insulin mRNA for translation	67
Mammalian CCR4–NOT binds and ubiquitinates 80S ribosomes to enforce translational stalling	66
Multiple allosteric mechanisms suppress PRC2 activity at active genes	65
Uncovering protein glycosylation dynamics and heterogeneity using deep quantitative glycoprofiling (DQGlyco)	65
A nuclear pore-anchored condensate enables germ granule organization and transgenerational epigenetic inheritance	64
Mutant tau filaments from some inherited frontotemporal dementias show the Alzheimer fold	63
Structural basis of the mechanism and inhibition of a human ceramide synthase	62
The cryo-EM structure of the human neurofibromin dimer reveals the molecular basis for neurofibromatosis type 1	61
Cryo-EM structure of the heteromeric TRPC1/TRPC4 channel	60
Structures of complete extracellular receptor assemblies mediated by IL-12 and IL-23	60
Tau modification by the norepinephrine metabolite DOPEGAL stimulates its pathology and propagation	60
Supporting structural biologists in Africa requires resources and capacity building	59
Structural insights into SV2A and the mechanism of racetam anticonvulsants	59
ISWI catalyzes nucleosome sliding in condensed nucleosome arrays	57
Structural insights into double-stranded RNA recognition and transport by SID-1	57
Transcription directionality is licensed by Integrator at active human promoters	57
Illuminating cortactin structure and function at actin filament branches	53
Structure of the poxvirus core	53
Structural insights into translocation and tailored synthesis of hyaluronan	52
Identifying nature’s smallest fractals	52
Structural features within the NORAD long noncoding RNA underlie efficient repression of Pumilio activity	52
Publisher Correction: Structure and activation of the RING E3 ubiquitin ligase TRIM72 on the membrane	51
Mechanism of actin filament severing and capping by gelsolin	51
Is it a wrap? Nucleosome interactions of the BRCA1-binding partner, BARD1, steal the scene	50
Fanconi anemia proteins participate in a break-induced-replication-like pathway to counter replication stress	50
Histone dynamics play a critical role in SNF2h-mediated nucleosome sliding	49
Effect of SARS-CoV-2 B.1.1.7 mutations on spike protein structure and function	49
Publisher Correction: A systems view of spliceosomal assembly and branchpoints with iCLIP	49
Embryogenesis without CTCF in flies and vertebrates	49
Fatty acid elongation by ELOVL condensing enzymes depends on a histidine nucleophile	48
mSWI/SNF promotes Polycomb repression both directly and through genome-wide redistribution	47
Chronicles of the human SAGA co-activator complex	46
Structures of the TRPM5 channel elucidate mechanisms of activation and inhibition	46
Structural insights into metazoan pretargeting GET complexes	46
Shifted PAMs generate DNA overhangs and enhance SpCas9 post-catalytic complex dissociation	45
Protein import into mitochondria — a new path through the membranes	44
POLQ to the rescue for double-strand break repair during mitosis	44
Elongation roadblocks mediated by dCas9 across human genes modulate transcription and nascent RNA processing	44
Identification of the bacteriophage nucleus protein interaction network	44
The Ruminococcus bromii amylosome protein Sas6 binds single and double helical α-glucan structures in starch	43

A novel class of inhibitors that disrupts the stability of integrin heterodimers identified by CRISPR-tiling-instructed genetic screens	42
Structural basis of human U5 snRNP late biogenesis and recycling	42
Mechanism of millisecond Lys48-linked poly-ubiquitin chain formation by cullin-RING ligases	42
Constitutive activation mechanism of a class C GPCR	42
Author Correction: Shifted PAMs generate DNA overhangs and enhance SpCas9 post-catalytic complex dissociation	42
Molecular basis for Gβγ-mediated activation of phosphoinositide 3-kinase γ	42
Shifting our perspective on orphan G protein-coupled receptors	41
Structure of human glycosylphosphatidylinositol transamidase	41
Structure-guided drug discovery: back to the future	41
Putting the antibiotics chloramphenicol and linezolid into context	41
Protein destabilization underlies pathogenic missense mutations in ARID1B	41
Gene regulation on extrachromosomal DNA	40
The partner-swapping sliding clamp loader exposed	40
Author Correction: It’s not just a phase: function and characteristics of RNA-binding proteins in phase separation	40
Visualizing maturation factor extraction from the nascent ribosome by the AAA-ATPase Drg1	40
Computational design of constitutively active cGAS	39
Mechanism of cyclic β-glucan export by ABC transporter Cgt of Brucella	39
The transcriptional terminator XRN2 and the RNA-binding protein Sam68 link alternative polyadenylation to cell cycle progression in prostate cancer	39
Short poly(A) tails are protected from deadenylation by the LARP1–PABP complex	38
Author Correction: Multiscale reorganization of the genome following DNA damage facilitates chromosome translocations via nuclear actin polymerization	38
Author Correction: A multipoint guidance mechanism for β-barrel folding on the SAM complex	38
The structure of pathogenic huntingtin exon 1 defines the bases of its aggregation propensity	38
When transcription initiation meets chromatin	38
Mechanism of receptor assembly via the pleiotropic adipokine Leptin	37
A co-transcriptional ribosome assembly checkpoint controls nascent large ribosomal subunit maturation	37
Structural basis for RNA slicing by a plant Argonaute	37
Fighting pain: the structure of gabapentin and its binding site in the Cavα2δ subunit	37
Author Correction: Polλ promotes microhomology-mediated end-joining	36
Publisher Correction: Fibrillin microfibril structure identifies long-range effects of inherited pathogenic mutations affecting a key regulatory latent TGFβ-binding site	36
Author Correction: RNA stability controlled by m6A methylation contributes to X-to-autosome dosage compensation in mammals	36
DELE1 oligomerization promotes integrated stress response activation	35
Structure reveals why genome folding is necessary for site-specific integration of foreign DNA into CRISPR arrays	35
Surviving under stress conditions	35
Captured: the elusive eukaryotic tRNA splicing enzyme	35
Alternative polyadenylation by sequential activation of distal and proximal PolyA sites	34
Structural insights into an intracellular biased agonist for GPCRs	34
Aberrant gene activation in synovial sarcoma relies on SSX specificity and increased PRC1.1 stability	34
Lis1 relieves cytoplasmic dynein-1 autoinhibition by acting as a molecular wedge	34
LYSET helps put the ‘lys’ in lysosomes	33
Reduction of DHHC5-mediated beclin 1 S-palmitoylation underlies autophagy decline in aging	33
Structure of AlkB–AlkG shows details of alkane terminal C–H selectivity and functionalization	33
A conformational switch controlling the toxicity of the prion protein	33
30 years of structural and molecular biology and counting	32
HP1 shapes embryonic genome architecture	32
Mesoscale chromatin confinement facilitates target search of pioneer transcription factors in live cells	31
Unwinding of a eukaryotic origin of replication visualized by cryo-EM	31
Cryo-EM reveals cholesterol binding in the lysosomal GPCR-like protein LYCHOS	31
Structural basis for CaVα2δ:gabapentin binding	31
The human ATAD5 has evolved unique structural elements to function exclusively as a PCNA unloader	31
Structure determination of inactive-state GPCRs with a universal nanobody	31
PARylated PDHE1α generates acetyl-CoA for local chromatin acetylation and DNA damage repair	31
Structure, dynamics and assembly of the ankyrin complex on human red blood cell membrane	31
Isoform-resolved mRNA profiling of ribosome load defines interplay of HIF and mTOR dysregulation in kidney cancer	30
Tropomyosin 1-I/C coordinates kinesin-1 and dynein motors during oskar mRNA transport	30
Molecular basis for substrate recognition and transport of human GABA transporter GAT1	30
Structural basis of TRPV1 modulation by endogenous bioactive lipids	30
PtuA and PtuB assemble into an inflammasome-like oligomer for anti-phage defense	29
Structural insights into the activation and inhibition of CXC chemokine receptor 3	29
The modes of action of ion-channel-targeting neurotoxic insecticides: lessons from structural biology	29
GPR161 structure uncovers the redundant role of sterol-regulated ciliary cAMP signaling in the Hedgehog pathway	28
Ensemble cryo-EM reveals conformational states of the nsp13 helicase in the SARS-CoV-2 helicase replication–transcription complex	28
Structural basis for processive daughter-strand synthesis and proofreading by the human leading-strand DNA polymerase Pol ε	28
Structural basis for NaV1.7 inhibition by pore blockers	28
Mechanism of RecF–RecO–RecR cooperation in bacterial homologous recombination	27
A unifying model for membrane protein biogenesis	27
Mechanisms of inward transmembrane proton translocation	27
Alternative splicing of CARM1 regulated by LincGET-guided paraspeckles biases the first cell fate in mammalian early embryos	27
Current challenges in understanding the role of enhancers in disease	27
Endocrine resistance and breast cancer plasticity are controlled by CoREST	27
Structural mechanism of muscle nicotinic receptor desensitization and block by curare	27
Snapshots of actin and tubulin folding inside the TRiC chaperonin	27
A PKA inhibitor motif within SMOOTHENED controls Hedgehog signal transduction	26
Molecular pathway of mitochondrial preprotein import through the TOM–TIM23 supercomplex	26
m6A governs length-dependent enrichment of mRNAs in stress granules	26
Structure of the SHOC2–MRAS–PP1C complex provides insights into RAF activation and Noonan syndrome	26
Exploration of novel αβ-protein folds through de novo design	26
Proton-triggered rearrangement of the AMPA receptor N-terminal domains impacts receptor kinetics and synaptic localization	26
A structural atlas for pain relief	25
Structures of aberrant spliceosome intermediates on their way to disassembly	25
Resistance of estrogen receptor function to BET bromodomain inhibition is mediated by transcriptional coactivator cooperativity	25

Visualizing the repair of broken DNA in living cells reveals a new mechanism for DNA homology search	25
A critical period of translational control during brain development at codon resolution	25
Plasticity in ligand recognition at somatostatin receptors	25
Breaking the K48-chain: linking ubiquitin beyond protein degradation	25
Coupling of distant ATPase domains in the circadian clock protein KaiC	25
Autophagosomes need calcium	24
A look into the dynamic process of proofreading in DNA polymerase-γ at near-atomic resolution	24
PIEZOs in vacuoles	24
Unlatching a window into the molecular landscape of prion toxicity	24
Ebola virus L–VP35 structure	24
Nature, more than nurture, of epigenetic states	24
Origins of meiotic recombination	24
Acetyl-CoA keeps PC stable	23
TCAIM is linked to lipid metabolism	23
OCT4 learns new tricks	23
A quantitative and site-specific atlas of the citrullinome reveals widespread existence of citrullination and insights into PADI4 substrates	23
Chemical modifications, ions and water molecules in the sub-2 Å resolution structure of the human 80S ribosome	23
MiOS, an integrated imaging and computational strategy to model gene folding with nucleosome resolution	23
Efficient selenium use by PRDX6 suppresses iron toxicity and ferroptosis	23
Transcription start site choice diversifies mRNA isoforms and defines cancer cell behavior	22
Bumper cars: trailing ribosome accelerates transcribing polymerase	22
SPT5 roles in transcriptional elongation	22
Cohesin closes the door on coexpression	22
Quantifying how promoter-associated nucleosomes regulate transcriptional bursting	22
Too much DNA demethylation breaks post-mitotic cells	22
DNA translocation hinges on cohesin	22
Human primase hangs on the primer–template and Polα to facilitate primer termination	22
CTCF-mediated 3D chromatin sets up the gene expression program in the male germline	22
Studying the impact of the nuclear topography on gene function	21
The guanylate-binding protein GBP1 forms a protein coat that enwraps cytosol-invasive bacteria	21
Identifying amyloid-related diseases by mapping mutations in low-complexity protein domains to pathologies	21
Publisher Correction: Molnupiravir: coding for catastrophe	21
A network of interacting ciliary tip proteins with opposing activities imparts slow and processive microtubule growth	21
Natural selection finds a way, even under heavy constraints	21
Deadenylation kinetics of mixed poly(A) tails at single-nucleotide resolution	21
Temporal and regional X-linked gene reactivation in the mouse germline reveals site-specific retention of epigenetic silencing	21
Structural basis of the histone ubiquitination read–write mechanism of RYBP–PRC1	21
Publisher Correction: HP1 shapes embryonic genome architecture	21
Structure and catalytic mechanism of exogenous fatty acid recycling by AasS, a versatile acyl-ACP synthetase	21
Binding NEMO: Liquid–liquid phase separation captures immune regulator	21
A mind-changing approach to the therapeutic use of psychedelics	21
Structural basis of the complete poxvirus transcription initiation process	21
BIDding on PROTACs in an era of antibiotic resistance	21
Signal-induced enhancer activation requires Ku70 to read topoisomerase1–DNA covalent complexes	21
Cryo-EM structure of the NDH–PSI–LHCI supercomplex from Spinacia oleracea	21
Extended and exposed enhancer RNAs activate transcription	21
Loss of H3K9 trimethylation alters chromosome compaction and transcription factor retention during mitosis	20
Author Correction: Structural basis of tRNA recognition by the m3C RNA methyltransferase METTL6 in complex with SerRS seryl-tRNA synthetase	20
Pol X DNA polymerases contribute to NHEJ flexibility	20
Dynamic epistasis analysis reveals how chromatin remodeling regulates transcriptional bursting	20
Publisher Correction: In vivo tracking of functionally tagged Rad51 unveils a robust strategy of homology search	20
Transport and inhibition mechanism of the human SGLT2–MAP17 glucose transporter	20
The conformational landscape of human transthyretin revealed by cryo-EM	20
From atoms to cells	20
Author Correction: Cryo-EM structure of an active central apparatus	20
PCNA recruits cohesin loader Scc2 to ensure sister chromatid cohesion	20
Evaluating the role of the nuclear microenvironment in gene function by population-based modeling	20
Initiation of ERAD by the bifunctional complex of Mnl1/Htm1 mannosidase and protein disulfide isomerase	20
Cryo-EM structure of the human THIK-1 K2P K+ channel reveals a lower Y gate regulated by lipids and anesthetics	20
Control of transcription elongation and DNA repair by alarmone ppGpp	20
Transcriptional repression upon S phase entry protects genome integrity in pluripotent cells	20
Mechanism of histone H2B monoubiquitination by Bre1	20
NSMB’s 30th anniversary: shining a light on the invisible	19
A fine balancing act: how epitranscriptome regulates dosage compensation in mammals	19
The NuA4 histone acetyltransferase: variations on a theme of SAGA	19
Author Correction: In vivo tracking of functionally tagged Rad51 unveils a robust strategy of homology search	19
DNA methylation restricts coordinated germline and neural fates in embryonic stem cell differentiation	19
Intra-promoter switch of transcription initiation sites in proliferation signaling-dependent RNA metabolism	19
Pioneers conquer core histones at the chromatin frontier	19
The molecular basis of drug selectivity for α5 subunit-containing GABAA receptors	19
Future opportunities in solute carrier structural biology	18
The risky business of ADP-ribosylating telomeric DNA	18
Complete set of the Atg8–E1–E2–E3 conjugation machinery forms an interaction web that mediates membrane shaping	18
Structure of adenylyl cyclase 5 in complex with Gβγ offers insights into ADCY5-related dyskinesia	18
Author Correction: RNA polymerase II pausing regulates chromatin organization in erythrocytes	18
THEMIS is a substrate and allosteric activator of SHP1, playing dual roles during T cell development	18
Autoinhibition of a clamp-loader ATPase revealed by deep mutagenesis and cryo-EM	18
Illuminating the role of chaperones in spliceosome biogenesis and recycling	18
Activation of CBASS Cap5 endonuclease immune effector by cyclic nucleotides	18
A personal perspective of the voltage-gated potassium channel studies	18