Physiology

Article	Citations
Pathophysiology of COVID-19: Mechanisms Underlying Disease Severity and Progression	142
The SLC25 Carrier Family: Important Transport Proteins in Mitochondrial Physiology and Pathology	76
Force Steadiness: From Motor Units to Voluntary Actions	66
Sex Differences in Human Thermoregulation: Relevance for 2020 and Beyond	64
Gut Microbial Metabolites and Blood Pressure Regulation: Focus on SCFAs and TMAO	39
Titin: A Tunable Spring in Active Muscle	32
Bile Acids, Their Receptors, and the Gut Microbiota	30
Polyamines in Gut Epithelial Renewal and Barrier Function	29
Intermittent Fasting: Physiological Implications on Outcomes in Mice and Men	27
Physiological Mechanisms of Acute Upper Thermal Tolerance in Fish	26
Adiponectin Synthesis, Secretion and Extravasation from Circulation to Interstitial Space	26
The Pathophysiology of Rett Syndrome With a Focus on Breathing Dysfunctions	25
Intratumoral Hypoxia and Mechanisms of Immune Evasion Mediated by Hypoxia-Inducible Factors	24
Gut Microbiota in Liver Disease: What Do We Know and What Do We Not Know?	22
Cellular Pathways Promoting Pulmonary Vascular Remodeling by Hypoxia	20
Multi-Level Regulation of Opioid-Induced Respiratory Depression	20
Immune Response to the Enteric ParasiteEntamoeba histolytica	19
Mechanisms of Lung Injury Induced by SARS-CoV-2 Infection	19
Time of Day and Muscle Strength: A Circadian Output?	18
Vascular Endothelial Protein Tyrosine Phosphatase Regulates Endothelial Function	18
High-Altitude Erythrocytosis: Mechanisms of Adaptive and Maladaptive Responses	17
From “Hunger Hormone” to “It’s Complicated”: Ghrelin Beyond Feeding Control	17
COVID-19 and Inborn Errors of Immunity	16
Differences and Similarities: The Richness of Comparative Sperm Physiology	16
Physiology of Glymphatic Solute Transport and Waste Clearance from the Brain	15

Physiological Impact of Hypothermia: The Good, the Bad, and the Ugly	15
Is It Good to Have a Stiff Aorta with Aging? Causes and Consequences	15
Precision Nutrition: Recent Advances in Obesity	15
Optogenetics: The Art of Illuminating Complex Signaling Pathways	14
What Can an Organ-on-a-Chip Teach Us About Human Lung Pathophysiology?	14
Insulin, Muscle Glucose Uptake, and Hexokinase: Revisiting the Road Not Taken	14
Carotid Body Inflammation: Role in Hypoxia and in the Anti-inflammatory Reflex	14
Parental Care, Destabilizing Selection, and the Evolution of Tetrapod Endothermy	13
More than Breathing Air: Evolutionary Drivers and Physiological Implications of an Amphibious Lifestyle in Fishes	12
Surviving in a Frozen Forest: the Physiology of Eastern Spruce Budworm Overwintering	12
Exercise-Pharmacology Interactions: Metformin, Statins, and Healthspan	12
Physics and Physiology of Cell Spreading in Two and Three Dimensions	12
Halogen-Induced Chemical Injury to the Mammalian Cardiopulmonary Systems	11
Phenotypic Frailty Assessment in Mice: Development, Discoveries, and Experimental Considerations	11
Air Pollution-Induced Autonomic Modulation	11
Deglutition and the Regulation of the Swallow Motor Pattern	11
Novel Protein Therapeutics Created Using the Elastin-Like Polypeptide Platform	11
Cannabinoid Receptors in Metabolic Regulation and Diabetes	10
Uterine Fibroids: Hiding in Plain Sight	10
Ion Transporter Gene Families as Physiological Targets of Natural Selection During Salinity Transitions in a Copepod	10
Multiple Facets and Roles of Na+-K+-Cl−Cotransport: Mechanisms and Therapeutic Implications	10
Sympathetic Innervation of White Adipose Tissue: to Beige or Not to Beige?	10
Angiotensin Receptor Blockers Are Not Just for Hypertension Anymore	10
Essential Role of Hemoglobin βCys93 in Cardiovascular Physiology	10
CatSper Calcium Channels: 20 Years On	9
Interplay of the Circadian Clock and Endothelin System	9
Fetal Growth Restriction and Asthma: Is the Damage Done?	8
Cold Exposure and the Metabolism of Mice, Men, and Other Wonderful Creatures	8
Remote Work During the COVID-19 Pandemic: Making the Best of It	8
NAFLD: An Emerging Causal Factor for Cardiovascular Disease	8
The Mechanobiology of Vascular Remodeling in the Aging Lung	8
Precision Medicine Approaches to Mental Health Care	8
Kv1.3 K+Channel Physiology Assessed by Genetic and Pharmacological Modulation	8
Promoting Nerve Regeneration: Electrical Stimulation, Gene Therapy, and Beyond	8
Cryptochromes in Mammals and Birds: Clock or Magnetic Compass?	8
Mitochondrial Metabolism in Hibernation: Regulation and Implications	8
Myosin Heavy Chain as a Novel Key Modulator of Striated Muscle Resting State	7
Nondipping Blood Pressure: Predictive or Reactive Failure of Renal Sodium Handling?	7
The Opto-Respiratory Compromise: Balancing Oxygen Supply and Light Transmittance in the Retina	7
Biological Significance of the Coupling Delay in Synchronized Oscillations	7
The Guts of the Opioid Crisis	7
Minimally Invasive Ways of Determining Circadian Rhythms in Humans	7
Effects of Developmental Hypoxia on the Vertebrate Cardiovascular System	6
Pathophysiology of Hemorrhage as It Relates to the Warfighter	6
The Stress of Lung Aging: Endoplasmic Reticulum and Senescence Tête-à-Tête	6
Kv Channel Ancillary Subunits: Where Do We Go from Here?	6
Noncytotoxic Roles of Granzymes in Health and Disease	5
Systemic Reprogramming of Endothelial Cell Signaling in Metastasis and Cachexia	5
Staying Hydrated in Seawater	5
What Evolutionary Evidence Implies About the Identity of the Mechanoelectrical Couplers in Vascular Smooth Muscle Cells	5

Advanced Modeling of Peripheral Neuro-Effector Communication and -Plasticity	5
Pulsatile Basal Insulin Secretion Is Driven by Glycolytic Oscillations	5
Therapeutic Targeting of Hypoxia-A2-Adenosinergic Pathway in COVID-19 Patients	5
Role of mTOR Signaling for Tubular Function and Disease	4
COVID-19 in Early Life: Infants and Children Are Affected Too	4
Endothelium-Derived Dopamine and 6-Nitrodopamine in the Cardiovascular System	4
Getting Fit to Counteract Cognitive Aging: Evidence and Future Directions	4
Recent Advances in Senolysis for Age-Related Diseases	4
Prefrontal Cortex Metabolome Is Modified by Opioids, Anesthesia, and Sleep	4
Microglia in Central Control of Metabolism	3
Sex based differences in muscle regeneration	3
Surviving in an Acidifying Ocean: Acid-Base Physiology and Energetics of the Sea Urchin Larva	3
Signaling through Free Fatty Acid Receptor 4 Attenuates Cardiometabolic Disease	3
Targeting Parasympathetic Activity to Improve Autonomic Tone and Clinical Outcomes	3
Circulating Cell-Free Mitochondrial DNA in Pregnancy	3
Pathophysiological Roles of the cGAS-STING Inflammatory Pathway	3
Organelle Communication: Joined in Sickness and in Health	2
Oral Supplementation with the Short-Chain Fatty Acid Acetate Ameliorates Age-Related Aortic Stiffening in Mice	2
Tracers and Imaging of Fatty Acid and Energy Metabolism of Human Adipose Tissues	2
A Year of Challenge and Change	2
Targeting adrenergic receptors to activate brown fat without cardiovascular effects	2
Preimmune Recognition and Response to Microbial Metabolites	2
Physiology in Perspective: A Key Role of Physiology in Understanding COVID-19	2
Physiological Needs: Sensations and Predictions in the Insular Cortex	2
Membrane Dynamics and Cation Handling in Ferroptosis	2
How and Why Does Metabolism Scale with Body Mass?	2
Pharmacological Advances in Incretin-Based Polyagonism: What We Know and What We Don’t	2
Complementing Cell Taxonomies with a Multicellular Analysis of Tissues	2
Physiological Functions of the Ubiquitin Ligases Nedd4-1 and Nedd4-2	2
CysLT1R is essential for optimal TLR4 responses and associated macrophage polarization and sepsis in response to LPS	2
Tissue Specificity of DNA Damage and Repair	2
Kidney Development: Recent Insights from Technological Advances	2
The nigro-vagal modulation of the proximal colon is compromised in a model of environmental Parkinson's Disease	2
Bifidobacterium bifidum prevents the IL-1B induced increase in intestinal permeability by a novel mechanism: TLR-2 dependent activation of PPAR-gamma and inhibition of NF-kB signaling pathway	2
RANKL and RANK in Cancer Therapy	2
The Elusive Hypertrophy of the Python Heart	2
Inflammatory Mechanisms in Heart Failure with Preserved Ejection Fraction	2
Physiological responses of adults with coronary artery disease during extreme heat exposure	2
Looking Forward to a Bright Future at APS	1
Physiological Societies Across the Globe Unite in an Effort to Handle the COVID-19 Pandemic	1
Homocysteine-induced Barrier Dysfunction and Hyperpermeability in the Blood-Brain and Blood-Retinal Barrier: Role of NLRP3 Inflammasome Pathway	1
Adiponectin receptor activation with AdipoRon prevents Truvada-induced microvascular oxidative stress and dysfunction in mice	1
Sex differences in swallowing response to Gaussian stochastic surface electrical stimulation	1
The Emerging Concept of Transportome: State of the Art	1
Tau Hyperphosphorylation in Brain Microvasculature: Relevance to Vascular Cognitive Impairment & Dementia (VCID)	1
From Beats to Metabolism: the Heart at the Core of Interorgan Metabolic Cross Talk	1
Glucocorticoid Receptor-beta (GRb) is a driver of adiposity via PPARgamma in adipose tissue: Lessons learned from the first CRISPR GRb KO animals	1
Effects of an exoskeleton-assisted walking program on bone strength in wheelchair individuals with spinal cord injury: A preliminary study using imaging and serum biomarkers	1
The role of Cola nitida on gastric acid secretion and its mechanism of action in male Wistar rats	1
Nutrition as Fuel for Human Spaceflight	1
Neonatal Alveolar Type 1 Cells Produce a Pro-inflammatory Response to LPS and TNF-alpha	1
Erythropoiesis-related RNAs biomarkers are sensitive and specific to low-dose erythropoietin treatment at sea level and altitude	1
Lysine acetylation regulates mitochondrial pyruvate carrier activity and cardiac pyruvate oxidation	1
TRPV4 functional status in cystic cells regulates cystogenesis in autosomal recessive polycystic kidney disease (ARPKD) during variations in dietary potassium	1
Emerging Pathophysiological Roles of Ketone Bodies	1
Pathophysiology of Acute Kidney Frailty	1
Salt-dependent Role of Human Gut Commensal Coprococcus comes in Blood Pressure and Inflammation	1
The impact of skipping a meal on perceived stress and mental distress	1
25-Hydroxycholesterol reduces aortic cellular senescence and stiffness in old mice	1
A reduction in Homeodomain Interacting Protein Kinase-2 in lung fibroblasts ameliorates lung fibrosis	1
4-octyl itaconate ameliorate cognitive impairment in 3xTg mouse model of Alzheimer's Disease	1
Immune Sexual Dimorphism: Connecting the Dots	1
Circadian Rhythm Regulation by Pacemaker Neuron Chloride Oscillation in Flies	1
Anticholinesterase and Antioxidant Potential of Aqueous Leave Extract of Phyllantus Amarus in Aluminium Chloride-Induced Alzheimer's Disease in Drosophila Melanogaster	1
Physiology in Perspective: Eat, Sleep, Survive—Natural Cycle of Life	1
Adhering to occupational heat stress recommendations attenuates kidney injury risk	1
Perivascular adipose and perivascular nerve dysfunction in inflammatory bowel disease is reversed after macrophage depletion	1
Dietary intake of macro and micronutrients correspond with sleep behaviors in collegiate female soccer players	1
Optogenetic therapy on cardiac vagal dysfunction-related ventricular arrhythmia in type 2 diabetes	1
Bacillus subtilis 67989 improves endothelial-mediated dilation in male mice fed a western diet	1
Logic of the Temporal Compartmentalization of the Hepatic Metabolic Cycle	1
Altered colonocyte differentiation may lead to decreased electrolyte and fluid absorption in the ileocolon of IBD patients by affecting the expression pattern of the responsible ion transporters	1
All Light, Everywhere? Photoreceptors at Nonconventional Sites	1
Two distinct calcium signaling behaviors are present in interstitial cells of Cajal of the gastroesophageal junction	1
A Population Health Approach to Promote Significant Learning in an Undergraduate Pathophysiology Course	1
MMP-13 Regulates Matrix Binding and Internalization of NG2/CSGP4 in Mandibular Fibrochondrocytes	1
Dendritic cell-specific SMAD3, downstream of JAK2, contributes to inflammation and salt-sensitivity of blood pressure in humans and mice	1
Senolytics reduce endothelial cell DNA damage and telomere dysfunction in old age	1
Promotion of hair growth by Lactobacillus and fermented traditional Korean berry in C57BL/6 mice	1
Bifidobacterium bifidum causes an enhancement of the intestinal epithelial tight junction barrier is mediated by TLR-2 dependent increases of Toll-interacting protein (TOLLIP) expression in a MYD88 in	1

Genetic inhibition of KV7/M-channels increases the excitability of bronchopulmonary vagal nociceptive nerves	1
Role of the Circadian Clock System in Trans-sulfuration Pathway and Tissue Remodeling	1
Fibroadipogenic progenitor-derived Gdf10 regulates neuromuscular junction and fat content in tongue muscles	1
Unraveling the role of estrogen signaling in the breast cancer-bone connection	1
The short-chain fatty acid acetate improves age-associated vascular endothelial dysfunction	1
Brief Smell Identification Test-1, An odor impairment Test in Patients of Depression	1
Early life stress in mice leads to impaired colonic corticosterone production and prolonged inflammation following induction of colitis	1
Electrophysiological characteristics of Panx1 channel and its purinergic regulation by P2X7 receptor	1
Physiology in Perspective: The New Normal—Life in a Pandemic	1
Mitochondria and renal microvascular dysfunction following ischemia-reperfusion in rats	1
Elucidating the role of Acinetobacter calcoaceticus in promoting intestinal inflammation	1
Cardiorespiratory Capacity and Body Composition are Improved with Concomitant Moderate Intensity or High-intensity Interval Training During Doxorubicin Treatment	1
Acute and reversible modulation of kidney proximal tubule endocytic capacity by fluid shear stress	1
Selective Breeding for High Intrinsic Exercise Capacity Slows Pan-Tissue Epigenetic Aging in Rats	1
Premenopausal women with PTSD display blunted vagal control of the heart and elevated central hemodynamics	1
IUPS: Physiology on a Global Scale	1
The Gut Microbiota and Metabolome and Brown Adipose Tissue Regulate the Enhanced Exercise Capacity in Mice with Disruption of the Regulator of G protein Signaling 14 (RGS14)	1
Identification of HMOX2 promoter variants linked to adaptation in Tibetans	1
Mosaic Loss of Y Chromosome in White Blood Cells: Its Impact on Men’s Health	1
Xanthine oxidase mediates stress-induced Alzheimer's Disease progression in triple transgenic mice	1
Mixed Matrix Thermoset Casting with Thermoplastic Fused Filament Fabrication 3D Printing	1
Succinate dehydrogenase inhibition decreases mitochondrial respiratory capacity in human airway smooth muscle cells	0
Exertional heart stroke causes long-term obesity and cardiac hypertrophy in mice	0
Impact of total parenteral nutrition and antibiotics on hepatic and intestinal homeostasis in pediatric murine model	0
Topographical Distribution and Morphology of Calcitonin Gene-Related Peptide (CGRP) Nociceptive Afferent Axons in the Flat-Mounts of the Whole Stomach in Male and Female Mice: Tracing, Digitization, a	0
Outbred, UM-HET3 mice have greater metabolic and arterial function than inbred, C57BL/6J mice	0
Impact of high fat diet and krill oil supplementation on spatial memory, microglia migration and neurogenesis in aged rats	0
Road to the 39th IUPS Congress Amid COVID-19 Pandemic: Every Cloud Has a Silver Lining	0
Analysis of distal convoluted tubule (DCT) cell de-differentiation due to COP9 signalosome (CSN) dysfunction via enriched DCT single-nucleus RNA-sequencing	0
Environmental enrichment reverses proulcerogenic action of social isolation on the gastric mucosa and increases resilience to pain stimuli and working capacity in a treadmill	0
Physiology in Perspective	0
Altered macrophage population and phenotype in mesenteric artery adventitia during inflammatory bowel disease pathogenesis	0
Setmelanotide, a melanocortin-4-receptor agonist, increases the hypercapnic ventilatory response and relieves hypoventilation in obese mice	0
Altered autonomic control or coronary artery blood flow by the aortic body chemoreceptors in conscious normotensive and hypertensive sheep	0
The effect of inhaled 7% CO2 on salivary cortisol and amylase in Behaviorally Inhibited and Non-Behaviorally Inhibited Humans	0
Mitochondrial Respiratory Function in Human Platelets: Influence of Sample Preparation, Assay Buffer and Instrumental Platform	0
Ventilatory Limitation in Patients with HFpEF and Obesity: The Balance Between Increased Ventilatory Demand vs. Reduced Ventilatory Capacity	0
Studies on the Mechanism of Lactate-Induced Increase in Ca2+ Oscillations in Carotid Body Type 1 Cells	0
The myocardial inflammasome and heart failure with reduced ejection fraction	0
Physiological limits in the world's extreme divers: how marine mammals manage CO2 accumulation and its effects on dive recovery	0
T-cell mitochondria exhibit a functional decline with obesity that is aggravated with weight loss	0
Plasma exosome derived MiR221 as a driver of long term hypoxia induced aberrations in pulmonary arterial phenotype in fetal sheep	0
An animal physiology Pressbook (OER) creation process, a synergistic collaboration with undergraduates and faculty	0
LIM kinase inhibition reduces endothelial cell cortical stiffness in diabetic arteries	0
Swallowing disrupts tongue-jaw coordination during chewing in a rat model of Parkinson's disease	0
Targeting LRP1 in a rodent cervical injury model to promote functional recovery	0
Thyroid hormone maintains cardiac dyadic structures by regulating junctophilin-2 localization to ryanodine clusters	0
Improving White Blood Cell Morphology Education Through Standardized Questions	0
Angiotensin II type 2 receptor-mediated dilation is greater in the cutaneous microvasculature of premenopausal women compared to men	0
Mediators of steatosis in HepG2 cells	0
Enteral protease inhibition mitigates impaired Windkessel function in experimental trauma/hemorrhagic shock	0
The Nuclear Receptor Corepressor in the Adrenal Gland Controls the Cell Fate of Aged Adrenocortical Cells	0
High-mobility group box 1 impairs renal microvascular autoregulatory responses in male and female rats	0
Caloric Restriction and Cardiovascular Health: the Good, the Bad, and the Renin-Angiotensin System	0
Impact of cannabidiol and lamotrigine on parameters of action potentials in sciatic nerves of frogs	0
TNF alpha induces mitophagy in human airway smooth muscle cells	0
Corrigendum for Lee CE, Volume 36, 2021, p. 335–349	0
TNFa-TNFRI interaction impairs endothelial calcium signaling and elevates blood pressure in obesity	0
Aortic baroreceptor afferent activity during systemic inflammation	0
Impairment of endothelial Pannexin1-TRPV4 signaling and flow-induced vasodilation in obesity-induced pulmonary hypertension	0
Approximate entropy showed greater tidal volume and breathing frequency variability during steady state exercise in healthy adolescents compared to adults	0
Potential roles of BNIP3 mediated placental mitophagy in the development of gestational diabetes mellitus	0
Hypothalamic PVN astrocytes fail to properly set glutamate tone in obese mice contributing to impaired glucose metabolism in this condition	0
The 5-HT1A agonist 8-OH-DPAT reverses the suppression of breathing but not swallowing caused by opioid administration in female rats	0
The potential role of matrix metalloproteinases on reducing small artery stiffness and improving vasodilation in old spontaneously hypertensive rats	0
The effect of acute oral pyridoxine supplementation on peripheral chemoreflex sensitivity in human hypertension	0
In utero Morphine Exposure Increases Blood Pressure in Association with Increased Markers of Sympathetic Activation in the Adult Offspring	0
Glucocorticoid excess and insulin resistance in aged spontaneously hypertensive rats/stroke-prone	0
Drosophila Clc-c as a model of human CLC-5 and Dent Disease type 1	0
The effect of Akt-induced skeletal muscle hypertrophy on the UBR family of E3 ubiquitin ligases	0
Prenatal Dexamethasone Programs Female-Biased Autonomic Dysregulation	0
Human skeletal muscle possesses an epigenetic memory of high intensity interval training affecting mitochondrial function	0
[18F-FDG] PET/CT monitoring of tissue-specific changes in cancer patients at risk for cachexia	0
The pedunculopontine tegmental nucleus is not important for breathing impairments observed in a Parkinson's disease model	0
Nicotine-mediated signaling in glomerular podocytes	0
Chronic Intermittent Hypoxia Facilitates Action Potential Firing in PVN-projecting MnPO Neurons	0
Bronchial thermoplasty attenuates bronchodilator responsiveness	0
Measurement of Maximum Velocity of the Succinate Dehydrogenase Reaction in Isolated Cardiomyocytes	0
High antioxidant load impairs cutaneous microvascular function in healthy women	0
Renal denervation modulates neurohormonal activity and inflammation in heart failure with preserved ejection fraction	0
Acute elevation of plasma β-hydroxybutyrate restores myocardial perfusion in aged mice	0
Fibroblast growth factor-21 attenuates olanzapine induced hyperglycemia	0
Impact of increasing insulin resistance on cerebral perfusion in adolescents	0
Treatment and healing of simple skin wounds with the use of medicinal plants	0
Input from afferent renal nerves is involved in progression of hypertensive heart failure through central vasopressin-mediated sympathoexcitation	0
Endothelial mesenchymal transition with air pollution mediated atherosclerosis: insights from single cell RNA sequencing and trajectory inference analysis	0
Oxaloacetate regulates mitochondrial complex II respiration in brown fat: dependence on UCP1 expression	0
Interleukin-1 beta Increases Glycolysis Through AKT and HIF-1 alpha in Colorectal Cancer Cells	0
Effects of sex and uninephrectomy on glomerular capillary morphology in rats	0
Motor neuron loss and neuromuscular transmission failure following chemogenetic inhibition of BDNF/TrkB signaling in adult rats	0
A novel RSK3/mAKAPß signalosome-focused gene therapy inhibits developing heart failure in aortic-banded, Western diet-fed female Ossabaw swine	0
Gastric Bypass reprograms hepatic clock machinery and improves glucose flux independent of weight	0
Chronic intermittent hypoxia induces remodeling of sympathetic innervation in mouse heart (atria and ventricles)	0
Assessment of Mitochondrial Function and Vascular Permeability in Lungs of Rats Susceptible to Hyperoxia-induced Acute Respiratory Distress Syndrome (ARDS)	0
The urothelium drives changes to urinary bladder smooth muscle contractility that mimic neurogenic inflammatory signaling	0