OOIR: Observatory of International Research

Papers

(The H4-Index of Cell Metabolism is 97. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2020-05-01 to 2024-05-01.)

Article	Citations
Association of Blood Glucose Control and Outcomes in Patients with COVID-19 and Pre-existing Type 2 Diabetes	1115
The Metabolic Underpinnings of Ferroptosis	609
Elevated Glucose Levels Favor SARS-CoV-2 Infection and Monocyte Response through a HIF-1α/Glycolysis-Dependent Axis	467
The hallmarks of cancer metabolism: Still emerging	412
Benefits of Metformin in Attenuating the Hallmarks of Aging	391
Omics-Driven Systems Interrogation of Metabolic Dysregulation in COVID-19 Pathogenesis	376
In-Hospital Use of Statins Is Associated with a Reduced Risk of Mortality among Individuals with COVID-19	375
CD36-mediated ferroptosis dampens intratumoral CD8+ T cell effector function and impairs their antitumor ability	366
Mitochondrial Metabolism as a Target for Cancer Therapy	334
Metformin Enhances Autophagy and Normalizes Mitochondrial Function to Alleviate Aging-Associated Inflammation	324
The Role of HIF in Immunity and Inflammation	317
The Immunomodulatory Metabolite Itaconate Modifies NLRP3 and Inhibits Inflammasome Activation	296
Effects of 4- and 6-h Time-Restricted Feeding on Weight and Cardiometabolic Health: A Randomized Controlled Trial in Adults with Obesity	283
Gut microbial metabolites facilitate anticancer therapy efficacy by modulating cytotoxic CD8+ T cell immunity	276
Exosomes as mediators of intercellular crosstalk in metabolism	265
Amino Assets: How Amino Acids Support Immunity	262
The Gut Microbiota in Prediabetes and Diabetes: A Population-Based Cross-Sectional Study	236
Defined p16High Senescent Cell Types Are Indispensable for Mouse Healthspan	234
Endothelial Lactate Controls Muscle Regeneration from Ischemia by Inducing M2-like Macrophage Polarization	227
SARS-CoV-2 infects human pancreatic β cells and elicits β cell impairment	226
Metabolic-Pathway-Based Subtyping of Triple-Negative Breast Cancer Reveals Potential Therapeutic Targets	223
Why does obesity cause diabetes?	213
Tumor-derived exosomes drive immunosuppressive macrophages in a pre-metastatic niche through glycolytic dominant metabolic reprogramming	206
SCENITH: A Flow Cytometry-Based Method to Functionally Profile Energy Metabolism with Single-Cell Resolution	203
Alpha-Ketoglutarate, an Endogenous Metabolite, Extends Lifespan and Compresses Morbidity in Aging Mice	202

Peroxidation of n-3 and n-6 polyunsaturated fatty acids in the acidic tumor environment leads to ferroptosis-mediated anticancer effects	200
SGLT2 Inhibition Mediates Protection from Diabetic Kidney Disease by Promoting Ketone Body-Induced mTORC1 Inhibition	198
Hyocholic acid species improve glucose homeostasis through a distinct TGR5 and FXR signaling mechanism	193
The adverse metabolic effects of branched-chain amino acids are mediated by isoleucine and valine	188
Human Brown Adipocyte Thermogenesis Is Driven by β2-AR Stimulation	187
Patch-Seq Links Single-Cell Transcriptomes to Human Islet Dysfunction in Diabetes	180
Microbiota-derived acetate enables the metabolic fitness of the brain innate immune system during health and disease	180
The Power of Plasticity—Metabolic Regulation of Hepatic Stellate Cells	178
Diabetes, obesity, metabolism, and SARS-CoV-2 infection: the end of the beginning	178
FXR activation protects against NAFLD via bile-acid-dependent reductions in lipid absorption	177
Changing global epidemiology of liver cancer from 2010 to 2019: NASH is the fastest growing cause of liver cancer	177
Extracellular vesicle-based interorgan transport of mitochondria from energetically stressed adipocytes	172
Plasticity of Epididymal Adipose Tissue in Response to Diet-Induced Obesity at Single-Nucleus Resolution	170
Targeting DGAT1 Ameliorates Glioblastoma by Increasing Fat Catabolism and Oxidative Stress	167
Positive feedback regulation of microglial glucose metabolism by histone H4 lysine 12 lactylation in Alzheimer’s disease	165
Intercellular Mitochondria Transfer to Macrophages Regulates White Adipose Tissue Homeostasis and Is Impaired in Obesity	164
Gut-Resident Lactobacilli Activate Hepatic Nrf2 and Protect Against Oxidative Liver Injury	161
Quantitative Fluxomics of Circulating Metabolites	157
The Gut Microbiota at the Service of Immunometabolism	156
A Universal Gut-Microbiome-Derived Signature Predicts Cirrhosis	153
Non-canonical Glutamate-Cysteine Ligase Activity Protects against Ferroptosis	153
Astrocyte-neuron metabolic cooperation shapes brain activity	150
Niacin Cures Systemic NAD+ Deficiency and Improves Muscle Performance in Adult-Onset Mitochondrial Myopathy	146
Tumors exploit FTO-mediated regulation of glycolytic metabolism to evade immune surveillance	143
MiR-690, an exosomal-derived miRNA from M2-polarized macrophages, improves insulin sensitivity in obese mice	142
NAD+ Metabolism Maintains Inducible PD-L1 Expression to Drive Tumor Immune Evasion	139
The pyruvate-lactate axis modulates cardiac hypertrophy and heart failure	136
SARS-CoV-2 Cell Entry Factors ACE2 and TMPRSS2 Are Expressed in the Microvasculature and Ducts of Human Pancreas but Are Not Enriched in β Cells	135
Gut-liver axis: Pathophysiological concepts and clinical implications	135
The glucose-dependent insulinotropic polypeptide (GIP) regulates body weight and food intake via CNS-GIPR signaling	134
The many actions of insulin in skeletal muscle, the paramount tissue determining glycemia	132
Expression of SARS-CoV-2 Entry Factors in the Pancreas of Normal Organ Donors and Individuals with COVID-19	131
Mitochondrial signal transduction	129
The global burden of metabolic disease: Data from 2000 to 2019	128
Mechanoresponsive metabolism in cancer cell migration and metastasis	128
Hyperglycemia in acute COVID-19 is characterized by insulin resistance and adipose tissue infectivity by SARS-CoV-2	127
Asparagine couples mitochondrial respiration to ATF4 activity and tumor growth	125
The NADPARK study: A randomized phase I trial of nicotinamide riboside supplementation in Parkinson’s disease	124
Bone Marrow Mesenchymal Stem Cells Support Acute Myeloid Leukemia Bioenergetics and Enhance Antioxidant Defense and Escape from Chemotherapy	123
A High-Density Human Mitochondrial Proximity Interaction Network	123
Quantitative high-confidence human mitochondrial proteome and its dynamics in cellular context	122
Immunometabolism in the Single-Cell Era	121
SARS-CoV-2 infection induces beta cell transdifferentiation	119
Sphingolipids in metabolic disease: The good, the bad, and the unknown	118
Excessive exercise training causes mitochondrial functional impairment and decreases glucose tolerance in healthy volunteers	118
Elevated Glucose Levels Favor SARS-CoV-2 Infection and Monocyte Response through a HIF-1α/Glycolysis-Dependent Axis	118
Cholesterol Stabilizes TAZ in Hepatocytes to Promote Experimental Non-alcoholic Steatohepatitis	117
High-fiber diet mitigates maternal obesity-induced cognitive and social dysfunction in the offspring via gut-brain axis	116
Ferroptosis heterogeneity in triple-negative breast cancer reveals an innovative immunotherapy combination strategy	115
Itaconate and itaconate derivatives target JAK1 to suppress alternative activation of macrophages	114

Glutathione Restricts Serine Metabolism to Preserve Regulatory T Cell Function	114
Polycystic ovary syndrome is transmitted via a transgenerational epigenetic process	113
Evolving concepts in NAD+ metabolism	112
Metformin Is Associated with Higher Incidence of Acidosis, but Not Mortality, in Individuals with COVID-19 and Pre-existing Type 2 Diabetes	111
Metabolic flexibility determines human NK cell functional fate in the tumor microenvironment	111
Pseudomonas aeruginosa Utilizes Host-Derived Itaconate to Redirect Its Metabolism to Promote Biofilm Formation	110
Molecular aspects of fructose metabolism and metabolic disease	110
Small Extracellular Vesicles Have GST Activity and Ameliorate Senescence-Related Tissue Damage	109
Insulin Treatment Is Associated with Increased Mortality in Patients with COVID-19 and Type 2 Diabetes	108
KIM-1 mediates fatty acid uptake by renal tubular cells to promote progressive diabetic kidney disease	108
The microbial metabolite trimethylamine N-oxide promotes antitumor immunity in triple-negative breast cancer	108
Metabolic orchestration of the wound healing response	104
Efferocytosis induces macrophage proliferation to help resolve tissue injury	104
Aerobic glycolysis promotes tumor immune evasion by hexokinase2-mediated phosphorylation of IκBα	103
Developmental and Tumor Angiogenesis Requires the Mitochondria-Shaping Protein Opa1	102
Hypothalamic detection of macronutrients via multiple gut-brain pathways	102
Oligodendrocytes Provide Antioxidant Defense Function for Neurons by Secreting Ferritin Heavy Chain	100
Cholesterol-induced toxicity: An integrated view of the role of cholesterol in multiple diseases	99
Current Concepts, Opportunities, and Challenges of Gut Microbiome-Based Personalized Medicine in Nonalcoholic Fatty Liver Disease	99
The Nuclear Receptor ESRRA Protects from Kidney Disease by Coupling Metabolism and Differentiation	98
Generation of a p16 Reporter Mouse and Its Use to Characterize and Target p16high Cells In Vivo	98
Meta-hallmarks of aging and cancer	97