OOIR: Observatory of International Research

Papers

(The H4-Index of Cell Metabolism is 91. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-11-01 to 2025-11-01.)

Article	Citations
Development of a functional beige fat cell line uncovers independent subclasses of cells expressing UCP1 and the futile creatine cycle	966
Time-restricted eating and exercise training improve HbA1c and body composition in women with overweight/obesity: A randomized controlled trial	633
Dopaminylation of endothelial TPI1 suppresses ferroptotic angiocrine signals to promote lung regeneration over fibrosis	559
The secret life of lactate: A novel cell-cycle regulatory mechanism	542
Association of genetic risk, lifestyle, and their interaction with obesity and obesity-related morbidities	541
Glucagon promotes increased hepatic mitochondrial oxidation and pyruvate carboxylase flux in humans with fatty liver disease	497
Lactate homeostasis is maintained through regulation of glycolysis and lipolysis	430
Sex- and timing-specific effects of fasting and caloric restriction	408
The Achilles heel of TNBCs: Ferroptosis heterogeneity	401
Lysine acetyltransferase 6A maintains CD4+ T cell response via epigenetic reprogramming of glucose metabolism in autoimmunity	375
Cap CASP, not SCAP, to fight steatohepatitis	356
Metabolic switch regulates lineage plasticity and induces synthetic lethality in triple-negative breast cancer	348
DMHPpp1r17 neurons regulate aging and lifespan in mice through hypothalamic-adipose inter-tissue communication	279
Sex and genetic background define the metabolic, physiologic, and molecular response to protein restriction	273
“Sweet death”: Fructose as a metabolic toxin that targets the gut-liver axis	265
Unveiling adipose populations linked to metabolic health in obesity	251
The Type 2 Diabetes Knowledge Portal: An open access genetic resource dedicated to type 2 diabetes and related traits	250
A hierarchical hepatic de novo lipogenesis substrate supply network utilizing pyruvate, acetate, and ketones	243
Dynamic scRNA-seq of live human pancreatic slices reveals functional endocrine cell neogenesis through an intermediate ducto-acinar stage	225
Kir2.1 channel: Macrophage plasticity in tumor microenvironment	224
Sugar addiction: An Achilles’ heel of auto-immune diseases?	219
Microvessels enhance vascularization and function of transplanted insulin-producing cells	212
mTOR takes charge: Relaying uncharged tRNA levels by mTOR ubiquitination	212
Fructose-1,6-bisphosphatase is a nonenzymatic safety valve that curtails AKT activation to prevent insulin hyperresponsiveness	205
Supercharging cancer-fighting T cells with lithium carbonate	201

Metabolic adaptation supports enhanced macrophage efferocytosis in limited-oxygen environments	197
Sphingolipid metabolism controls mammalian heart regeneration	194
The integrated stress response fine-tunes stem cell fate decisions upon serine deprivation and tissue injury	191
Nutrient allocation fuels T cell-mediated immunity	189
Spatial regulation of glucose and lipid metabolism by hepatic insulin signaling	170
A novel protein CYTB-187AA encoded by the mitochondrial gene CYTB modulates mammalian early development	169
Metabolic regulation of the glioblastoma stem cell epitranscriptome by malate dehydrogenase 2	167
Mitochondrial membrane lipids in the regulation of bioenergetic flux	166
The cephalic phase of insulin release is modulated by IL-1β	164
Isolation of extracellular fluids reveals novel secreted bioactive proteins from muscle and fat tissues	164
PHGDH-mediated endothelial metabolism drives glioblastoma resistance to chimeric antigen receptor T cell immunotherapy	162
PHLDA2-mediated phosphatidic acid peroxidation triggers a distinct ferroptotic response during tumor suppression	161
STING orchestrates the crosstalk between polyunsaturated fatty acid metabolism and inflammatory responses	161
A microbial metabolite inhibits the HIF-2α-ceramide pathway to mediate the beneficial effects of time-restricted feeding on MASH	160
Testing the carbohydrate-insulin model: Short-term metabolic responses to consumption of meals with varying glycemic index in healthy adults	155
Understanding the metabolism of infants using whole-body metabolic models	155
HNF1A and A1CF coordinate a beta cell transcription-splicing axis that is disrupted in type 2 diabetes	154
Localized GLP1 receptor pre-internalization directs pancreatic alpha cell to beta cell communication	153
Bone marrow immune cells respond to fluctuating nutritional stress to constrain weight regain	153
MGAT2 inhibitor decreases liver fibrosis and inflammation in murine NASH models and reduces body weight in human adults with obesity	143
Maternal circadian rhythms during pregnancy dictate metabolic plasticity in offspring	142
PDIA3 defines a novel subset of adipose macrophages to exacerbate the development of obesity and metabolic disorders	141
Evaluating human genetic support for hypothesized metabolic disease genes	140
Amino acid is a major carbon source for hepatic lipogenesis	138
Di-methylation of CD147-K234 Promotes the Progression of NSCLC by Enhancing Lactate Export	136
Defend or reproduce? Muscle-derived glutamate determines an immune-reproductive energetic tradeoff	133
Paraventricular glia drive circuit function to control metabolism	132
Focus on diet and exercise	131
Targeting PDAC metabolism: Environment determines what has GOT2 give	128
Excess pancreatic elastase alters acinar-β cell communication by impairing the mechano-signaling and the PAR2 pathways	127
Organ-specific fuel rewiring in acute and chronic hypoxia redistributes glucose and fatty acid metabolism	127
The crosstalk between bone remodeling and energy metabolism: A translational perspective	126
Molecular mechanisms of snoRNA-IL-15 crosstalk in adipocyte lipolysis and NK cell rejuvenation	125
The past, present, and future physiology and pharmacology of glucagon	124
EHBP1 suppresses liver fibrosis in metabolic dysfunction-associated steatohepatitis	124
Early prediction of incident liver disease using conventional risk factors and gut-microbiome-augmented gradient boosting	123
Aerobic glycolysis promotes tumor immune evasion by hexokinase2-mediated phosphorylation of IκBα	122
Glutamate metabolism directs energetic trade-offs to shape host-pathogen susceptibility in Drosophila	120
Effect of alternate day fasting combined with aerobic exercise on non-alcoholic fatty liver disease: A randomized controlled trial	118
Famsin and fasting adaptation: A glucagon connection	117
Exosomal miR-302b rejuvenates aging mice by reversing the proliferative arrest of senescent cells	117
“Shunt-ing” down obesity with novel endogenous metabolites	116
Dietary-timing-induced gut microbiota diurnal oscillations modulate inflammatory rhythms in rheumatoid arthritis	115
Biting into a union of oncology and metabolism through leukemic stem cells	112
Response to Paik et al. on the disease burden of NAFLD	110
Microbiome-derived metabolites counteract tumor-induced immunosuppression and boost immune checkpoint blockade	110
Obesity-associated microglial inflammatory activation paradoxically improves glucose tolerance	109
Targeting gut microbial nitrogen recycling and cellular uptake of ammonium to improve bortezomib resistance in multiple myeloma	108
Liver microbes controlling immunity: Facts and pitfalls	107
A key role of PIEZO2 mechanosensitive ion channel in adipose sensory innervation	105

Anti-seizure effects of norepinephrine-induced free fatty acid release	105
Psychological stress-induced microbial metabolite indole-3-acetate disrupts intestinal cell lineage commitment	103
Understanding the variation in exercise responses to guide personalized physical activity prescriptions	102
Beggars banquet: Metabolism in the tumor immune microenvironment and cancer therapy	102
Tumor-associated macrophages are shaped by intratumoral high potassium via Kir2.1	101
Linoleic acid potentiates CD8+ T cell metabolic fitness and antitumor immunity	98
Defects in a liver-bone axis contribute to hepatic osteodystrophy disease progression	97
Single-cell transcriptomic and spatial landscapes of the developing human pancreas	97
Cancer cells co-opt nociceptive nerves to thrive in nutrient-poor environments and upon nutrient-starvation therapies	97
Deciphering the metabolic heterogeneity of hematopoietic stem cells with single-cell resolution	97
Cardiometabolic health improvements upon dietary intervention are driven by tissue-specific insulin resistance phenotype: A precision nutrition trial	96
Selenium mediates exercise-induced adult neurogenesis and reverses learning deficits induced by hippocampal injury and aging	96
Effects on weight loss and glycemic control with SAR441255, a potent unimolecular peptide GLP-1/GIP/GCG receptor triagonist	93
Glycometabolic reprogramming-induced XRCC1 lactylation confers therapeutic resistance in ALDH1A3-overexpressing glioblastoma	92
Microglial lipid droplet accumulation in tauopathy brain is regulated by neuronal AMPK	91
Emerging therapies in cancer metabolism	91