OOIR: Observatory of International Research

Papers

(The H4-Index of Cell Metabolism is 92. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-07-01 to 2025-07-01.)

Article	Citations
The secret life of lactate: A novel cell-cycle regulatory mechanism	844
Cap CASP, not SCAP, to fight steatohepatitis	526
The Achilles heel of TNBCs: Ferroptosis heterogeneity	504
The search for thermoregulatory neurons is heating up	450
Lysine acetyltransferase 6A maintains CD4+ T cell response via epigenetic reprogramming of glucose metabolism in autoimmunity	446
Sex- and timing-specific effects of fasting and caloric restriction	393
Unveiling adipose populations linked to metabolic health in obesity	392
Association of genetic risk, lifestyle, and their interaction with obesity and obesity-related morbidities	392
Development of a functional beige fat cell line uncovers independent subclasses of cells expressing UCP1 and the futile creatine cycle	363
The Type 2 Diabetes Knowledge Portal: An open access genetic resource dedicated to type 2 diabetes and related traits	343
“Sweet death”: Fructose as a metabolic toxin that targets the gut-liver axis	342
Dopaminylation of endothelial TPI1 suppresses ferroptotic angiocrine signals to promote lung regeneration over fibrosis	329
Time-restricted eating and exercise training improve HbA1c and body composition in women with overweight/obesity: A randomized controlled trial	323
DMHPpp1r17 neurons regulate aging and lifespan in mice through hypothalamic-adipose inter-tissue communication	318
Sex and genetic background define the metabolic, physiologic, and molecular response to protein restriction	306
Lactate homeostasis is maintained through regulation of glycolysis and lipolysis	295
Glucagon promotes increased hepatic mitochondrial oxidation and pyruvate carboxylase flux in humans with fatty liver disease	294
Metabolic switch regulates lineage plasticity and induces synthetic lethality in triple-negative breast cancer	294
Adipocyte iron levels impinge on a fat-gut crosstalk to regulate intestinal lipid absorption and mediate protection from obesity	278
Spatial regulation of glucose and lipid metabolism by hepatic insulin signaling	241
Microvessels enhance vascularization and function of transplanted insulin-producing cells	234
Supercharging cancer-fighting T cells with lithium carbonate	229
Sugar addiction: An Achilles’ heel of auto-immune diseases?	218
Kir2.1 channel: Macrophage plasticity in tumor microenvironment	212
Metabolic regulation of the glioblastoma stem cell epitranscriptome by malate dehydrogenase 2	207

Dynamic scRNA-seq of live human pancreatic slices reveals functional endocrine cell neogenesis through an intermediate ducto-acinar stage	206
A hierarchical hepatic de novo lipogenesis substrate supply network utilizing pyruvate, acetate, and ketones	202
The integrated stress response fine-tunes stem cell fate decisions upon serine deprivation and tissue injury	201
PHLDA2-mediated phosphatidic acid peroxidation triggers a distinct ferroptotic response during tumor suppression	198
The cephalic phase of insulin release is modulated by IL-1β	194
Mitochondrial cristae-remodeling protein OPA1 in POMC neurons couples Ca2+ homeostasis with adipose tissue lipolysis	194
Isolation of extracellular fluids reveals novel secreted bioactive proteins from muscle and fat tissues	189
PHGDH-mediated endothelial metabolism drives glioblastoma resistance to chimeric antigen receptor T cell immunotherapy	175
Metabolic adaptation supports enhanced macrophage efferocytosis in limited-oxygen environments	172
Sphingolipid metabolism controls mammalian heart regeneration	172
Adhesion-mediated mechanosignaling forces mitohormesis	169
mTOR takes charge: Relaying uncharged tRNA levels by mTOR ubiquitination	167
A novel protein CYTB-187AA encoded by the mitochondrial gene CYTB modulates mammalian early development	163
Fructose-1,6-bisphosphatase is a nonenzymatic safety valve that curtails AKT activation to prevent insulin hyperresponsiveness	160
FXR activation protects against NAFLD via bile-acid-dependent reductions in lipid absorption	158
STING orchestrates the crosstalk between polyunsaturated fatty acid metabolism and inflammatory responses	155
A microbial metabolite inhibits the HIF-2α-ceramide pathway to mediate the beneficial effects of time-restricted feeding on MASH	154
Mitochondrial membrane lipids in the regulation of bioenergetic flux	154
Excess pancreatic elastase alters acinar-β cell communication by impairing the mechano-signaling and the PAR2 pathways	150
EHBP1 suppresses liver fibrosis in metabolic dysfunction-associated steatohepatitis	147
Testing the carbohydrate-insulin model: Short-term metabolic responses to consumption of meals with varying glycemic index in healthy adults	147
Di-methylation of CD147-K234 Promotes the Progression of NSCLC by Enhancing Lactate Export	146
Understanding the metabolism of infants using whole-body metabolic models	145
Defend or reproduce? Muscle-derived glutamate determines an immune-reproductive energetic tradeoff	144
Paraventricular glia drive circuit function to control metabolism	140
Focus on diet and exercise	139
Targeting PDAC metabolism: Environment determines what has GOT2 give	139
The crosstalk between bone remodeling and energy metabolism: A translational perspective	139
MGAT2 inhibitor decreases liver fibrosis and inflammation in murine NASH models and reduces body weight in human adults with obesity	136
Maternal circadian rhythms during pregnancy dictate metabolic plasticity in offspring	132
Organ-specific fuel rewiring in acute and chronic hypoxia redistributes glucose and fatty acid metabolism	130
Glutamate metabolism directs energetic trade-offs to shape host-pathogen susceptibility in Drosophila	129
The past, present, and future physiology and pharmacology of glucagon	128
Early prediction of incident liver disease using conventional risk factors and gut-microbiome-augmented gradient boosting	126
Evaluating human genetic support for hypothesized metabolic disease genes	125
PDIA3 defines a novel subset of adipose macrophages to exacerbate the development of obesity and metabolic disorders	124
Effect of alternate day fasting combined with aerobic exercise on non-alcoholic fatty liver disease: A randomized controlled trial	123
Molecular mechanisms of snoRNA-IL-15 crosstalk in adipocyte lipolysis and NK cell rejuvenation	122
Amino acid is a major carbon source for hepatic lipogenesis	119
Exosomes as mediators of intercellular crosstalk in metabolism	119
Exosomal miR-302b rejuvenates aging mice by reversing the proliferative arrest of senescent cells	118
Aerobic glycolysis promotes tumor immune evasion by hexokinase2-mediated phosphorylation of IκBα	118
Response to Paik et al. on the disease burden of NAFLD	117
Bone marrow immune cells respond to fluctuating nutritional stress to constrain weight regain	117
Biting into a union of oncology and metabolism through leukemic stem cells	116
Famsin and fasting adaptation: A glucagon connection	116
Liver microbes controlling immunity: Facts and pitfalls	114
“Shunt-ing” down obesity with novel endogenous metabolites	114
Dietary-timing-induced gut microbiota diurnal oscillations modulate inflammatory rhythms in rheumatoid arthritis	114
Anti-seizure effects of norepinephrine-induced free fatty acid release	113

A key role of PIEZO2 mechanosensitive ion channel in adipose sensory innervation	113
Microglial lipid droplet accumulation in tauopathy brain is regulated by neuronal AMPK	110
Microbiome-derived metabolites counteract tumor-induced immunosuppression and boost immune checkpoint blockade	109
Obesity-associated microglial inflammatory activation paradoxically improves glucose tolerance	104
Effects on weight loss and glycemic control with SAR441255, a potent unimolecular peptide GLP-1/GIP/GCG receptor triagonist	102
Cancer cells co-opt nociceptive nerves to thrive in nutrient-poor environments and upon nutrient-starvation therapies	102
Single-cell transcriptomic and spatial landscapes of the developing human pancreas	99
Defects in a liver-bone axis contribute to hepatic osteodystrophy disease progression	99
Psychological stress-induced microbial metabolite indole-3-acetate disrupts intestinal cell lineage commitment	98
Linoleic acid potentiates CD8+ T cell metabolic fitness and antitumor immunity	98
Selenium mediates exercise-induced adult neurogenesis and reverses learning deficits induced by hippocampal injury and aging	98
Cardiometabolic health improvements upon dietary intervention are driven by tissue-specific insulin resistance phenotype: A precision nutrition trial	98
Cardiovascular disease in diabetes, beyond glucose	97
Tumor-associated macrophages are shaped by intratumoral high potassium via Kir2.1	96
Glycometabolic reprogramming-induced XRCC1 lactylation confers therapeutic resistance in ALDH1A3-overexpressing glioblastoma	93
Understanding the variation in exercise responses to guide personalized physical activity prescriptions	93
Emerging therapies in cancer metabolism	93
Extracellular vesicles in fatty liver promote a metastatic tumor microenvironment	92
Lactobacillus plantarum-derived indole-3-lactic acid ameliorates colorectal tumorigenesis via epigenetic regulation of CD8+ T cell immunity	92