OOIR: Observatory of International Research

Papers

(The H4-Index of Cell Metabolism is 93. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-06-01 to 2025-06-01.)

Article	Citations
The secret life of lactate: A novel cell-cycle regulatory mechanism	809
Cap CASP, not SCAP, to fight steatohepatitis	495
The Achilles heel of TNBCs: Ferroptosis heterogeneity	487
The search for thermoregulatory neurons is heating up	421
Lysine acetyltransferase 6A maintains CD4+ T cell response via epigenetic reprogramming of glucose metabolism in autoimmunity	412
Sex- and timing-specific effects of fasting and caloric restriction	371
Lactate homeostasis is maintained through regulation of glycolysis and lipolysis	371
The Type 2 Diabetes Knowledge Portal: An open access genetic resource dedicated to type 2 diabetes and related traits	366
Sex and genetic background define the metabolic, physiologic, and molecular response to protein restriction	355
Dopaminylation of endothelial TPI1 suppresses ferroptotic angiocrine signals to promote lung regeneration over fibrosis	325
Adipocyte iron levels impinge on a fat-gut crosstalk to regulate intestinal lipid absorption and mediate protection from obesity	320
Unveiling adipose populations linked to metabolic health in obesity	318
Time-restricted eating and exercise training improve HbA1c and body composition in women with overweight/obesity: A randomized controlled trial	309
DMHPpp1r17 neurons regulate aging and lifespan in mice through hypothalamic-adipose inter-tissue communication	306
“Sweet death”: Fructose as a metabolic toxin that targets the gut-liver axis	291
Metabolic switch regulates lineage plasticity and induces synthetic lethality in triple-negative breast cancer	288
Association of genetic risk, lifestyle, and their interaction with obesity and obesity-related morbidities	276
Development of a functional beige fat cell line uncovers independent subclasses of cells expressing UCP1 and the futile creatine cycle	273
Glucagon promotes increased hepatic mitochondrial oxidation and pyruvate carboxylase flux in humans with fatty liver disease	272
Mitochondrial cristae-remodeling protein OPA1 in POMC neurons couples Ca2+ homeostasis with adipose tissue lipolysis	238
Supercharging cancer-fighting T cells with lithium carbonate	232
Spatial regulation of glucose and lipid metabolism by hepatic insulin signaling	225
Microvessels enhance vascularization and function of transplanted insulin-producing cells	220
Creatine promotes metastatic dissemination	212
Sugar addiction: An Achilles’ heel of auto-immune diseases?	200

Kir2.1 channel: Macrophage plasticity in tumor microenvironment	198
Metabolic adaptation supports enhanced macrophage efferocytosis in limited-oxygen environments	198
Sphingolipid metabolism controls mammalian heart regeneration	193
A hierarchical hepatic de novo lipogenesis substrate supply network utilizing pyruvate, acetate, and ketones	191
PHLDA2-mediated phosphatidic acid peroxidation triggers a distinct ferroptotic response during tumor suppression	189
mTOR takes charge: Relaying uncharged tRNA levels by mTOR ubiquitination	189
Metabolic regulation of the glioblastoma stem cell epitranscriptome by malate dehydrogenase 2	185
Dynamic scRNA-seq of live human pancreatic slices reveals functional endocrine cell neogenesis through an intermediate ducto-acinar stage	182
Mitochondrial membrane lipids in the regulation of bioenergetic flux	177
The cephalic phase of insulin release is modulated by IL-1β	171
Isolation of extracellular fluids reveals novel secreted bioactive proteins from muscle and fat tissues	170
A novel protein CYTB-187AA encoded by the mitochondrial gene CYTB modulates mammalian early development	169
Fructose-1,6-bisphosphatase is a nonenzymatic safety valve that curtails AKT activation to prevent insulin hyperresponsiveness	163
STING orchestrates the crosstalk between polyunsaturated fatty acid metabolism and inflammatory responses	160
PHGDH-mediated endothelial metabolism drives glioblastoma resistance to chimeric antigen receptor T cell immunotherapy	160
Adhesion-mediated mechanosignaling forces mitohormesis	160
FXR activation protects against NAFLD via bile-acid-dependent reductions in lipid absorption	157
MGAT2 inhibitor decreases liver fibrosis and inflammation in murine NASH models and reduces body weight in human adults with obesity	155
A microbial metabolite inhibits the HIF-2α-ceramide pathway to mediate the beneficial effects of time-restricted feeding on MASH	154
Maternal circadian rhythms during pregnancy dictate metabolic plasticity in offspring	149
Bone marrow immune cells respond to fluctuating nutritional stress to constrain weight regain	146
Di-methylation of CD147-K234 Promotes the Progression of NSCLC by Enhancing Lactate Export	144
Understanding the metabolism of infants using whole-body metabolic models	142
Defend or reproduce? Muscle-derived glutamate determines an immune-reproductive energetic tradeoff	139
Focus on diet and exercise	139
Paraventricular glia drive circuit function to control metabolism	139
The crosstalk between bone remodeling and energy metabolism: A translational perspective	137
Targeting PDAC metabolism: Environment determines what has GOT2 give	137
EHBP1 suppresses liver fibrosis in metabolic dysfunction-associated steatohepatitis	136
Early prediction of incident liver disease using conventional risk factors and gut-microbiome-augmented gradient boosting	136
Molecular mechanisms of snoRNA-IL-15 crosstalk in adipocyte lipolysis and NK cell rejuvenation	134
Glutamate metabolism directs energetic trade-offs to shape host-pathogen susceptibility in Drosophila	133
Exosomal miR-302b rejuvenates aging mice by reversing the proliferative arrest of senescent cells	128
Effect of alternate day fasting combined with aerobic exercise on non-alcoholic fatty liver disease: A randomized controlled trial	127
Excess pancreatic elastase alters acinar-β cell communication by impairing the mechano-signaling and the PAR2 pathways	125
Amino acid is a major carbon source for hepatic lipogenesis	123
Organ-specific fuel rewiring in acute and chronic hypoxia redistributes glucose and fatty acid metabolism	122
Aerobic glycolysis promotes tumor immune evasion by hexokinase2-mediated phosphorylation of IκBα	122
PDIA3 defines a novel subset of adipose macrophages to exacerbate the development of obesity and metabolic disorders	121
Exosomes as mediators of intercellular crosstalk in metabolism	121
Testing the carbohydrate-insulin model: Short-term metabolic responses to consumption of meals with varying glycemic index in healthy adults	120
The past, present, and future physiology and pharmacology of glucagon	119
Evaluating human genetic support for hypothesized metabolic disease genes	115
Response to Paik et al. on the disease burden of NAFLD	114
Biting into a union of oncology and metabolism through leukemic stem cells	114
Anti-seizure effects of norepinephrine-induced free fatty acid release	113
Can tumor cells take it all away?	111
Famsin and fasting adaptation: A glucagon connection	111
Beggars banquet: Metabolism in the tumor immune microenvironment and cancer therapy	110
Liver microbes controlling immunity: Facts and pitfalls	110

Cardiovascular disease in diabetes, beyond glucose	110
“Shunt-ing” down obesity with novel endogenous metabolites	110
A key role of PIEZO2 mechanosensitive ion channel in adipose sensory innervation	109
Cancer cells co-opt nociceptive nerves to thrive in nutrient-poor environments and upon nutrient-starvation therapies	109
Tumor-associated macrophages are shaped by intratumoral high potassium via Kir2.1	108
Selenium mediates exercise-induced adult neurogenesis and reverses learning deficits induced by hippocampal injury and aging	106
Microbiome-derived metabolites counteract tumor-induced immunosuppression and boost immune checkpoint blockade	106
Deciphering the metabolic heterogeneity of hematopoietic stem cells with single-cell resolution	103
Understanding the variation in exercise responses to guide personalized physical activity prescriptions	103
Glycometabolic reprogramming-induced XRCC1 lactylation confers therapeutic resistance in ALDH1A3-overexpressing glioblastoma	101
Single-cell transcriptomic and spatial landscapes of the developing human pancreas	98
Obesity-associated microglial inflammatory activation paradoxically improves glucose tolerance	97
Defects in a liver-bone axis contribute to hepatic osteodystrophy disease progression	96
Cardiometabolic health improvements upon dietary intervention are driven by tissue-specific insulin resistance phenotype: A precision nutrition trial	96
Linoleic acid potentiates CD8+ T cell metabolic fitness and antitumor immunity	96
Effects on weight loss and glycemic control with SAR441255, a potent unimolecular peptide GLP-1/GIP/GCG receptor triagonist	95
Targeting gut microbial nitrogen recycling and cellular uptake of ammonium to improve bortezomib resistance in multiple myeloma	95
Dietary-timing-induced gut microbiota diurnal oscillations modulate inflammatory rhythms in rheumatoid arthritis	94
Emerging therapies in cancer metabolism	93