OOIR: Observatory of International Research

Papers

(The H4-Index of Cell Metabolism is 91. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-09-01 to 2025-09-01.)

Article	Citations
Cap CASP, not SCAP, to fight steatohepatitis	904
Sex- and timing-specific effects of fasting and caloric restriction	575
The secret life of lactate: A novel cell-cycle regulatory mechanism	543
Sex and genetic background define the metabolic, physiologic, and molecular response to protein restriction	500
Lysine acetyltransferase 6A maintains CD4+ T cell response via epigenetic reprogramming of glucose metabolism in autoimmunity	496
DMHPpp1r17 neurons regulate aging and lifespan in mice through hypothalamic-adipose inter-tissue communication	478
Development of a functional beige fat cell line uncovers independent subclasses of cells expressing UCP1 and the futile creatine cycle	435
The Achilles heel of TNBCs: Ferroptosis heterogeneity	406
Dopaminylation of endothelial TPI1 suppresses ferroptotic angiocrine signals to promote lung regeneration over fibrosis	391
“Sweet death”: Fructose as a metabolic toxin that targets the gut-liver axis	381
Association of genetic risk, lifestyle, and their interaction with obesity and obesity-related morbidities	372
Time-restricted eating and exercise training improve HbA1c and body composition in women with overweight/obesity: A randomized controlled trial	337
Glucagon promotes increased hepatic mitochondrial oxidation and pyruvate carboxylase flux in humans with fatty liver disease	336
Metabolic switch regulates lineage plasticity and induces synthetic lethality in triple-negative breast cancer	320
Lactate homeostasis is maintained through regulation of glycolysis and lipolysis	297
Unveiling adipose populations linked to metabolic health in obesity	260
The Type 2 Diabetes Knowledge Portal: An open access genetic resource dedicated to type 2 diabetes and related traits	254
Microvessels enhance vascularization and function of transplanted insulin-producing cells	238
mTOR takes charge: Relaying uncharged tRNA levels by mTOR ubiquitination	229
Dynamic scRNA-seq of live human pancreatic slices reveals functional endocrine cell neogenesis through an intermediate ducto-acinar stage	227
Fructose-1,6-bisphosphatase is a nonenzymatic safety valve that curtails AKT activation to prevent insulin hyperresponsiveness	226
Mitochondrial membrane lipids in the regulation of bioenergetic flux	225
Spatial regulation of glucose and lipid metabolism by hepatic insulin signaling	213
PHGDH-mediated endothelial metabolism drives glioblastoma resistance to chimeric antigen receptor T cell immunotherapy	208
Sugar addiction: An Achilles’ heel of auto-immune diseases?	205

Kir2.1 channel: Macrophage plasticity in tumor microenvironment	204
Supercharging cancer-fighting T cells with lithium carbonate	200
Metabolic regulation of the glioblastoma stem cell epitranscriptome by malate dehydrogenase 2	188
The integrated stress response fine-tunes stem cell fate decisions upon serine deprivation and tissue injury	185
The cephalic phase of insulin release is modulated by IL-1β	184
A hierarchical hepatic de novo lipogenesis substrate supply network utilizing pyruvate, acetate, and ketones	184
Isolation of extracellular fluids reveals novel secreted bioactive proteins from muscle and fat tissues	180
Mitochondrial cristae-remodeling protein OPA1 in POMC neurons couples Ca2+ homeostasis with adipose tissue lipolysis	177
Metabolic adaptation supports enhanced macrophage efferocytosis in limited-oxygen environments	174
Sphingolipid metabolism controls mammalian heart regeneration	163
PHLDA2-mediated phosphatidic acid peroxidation triggers a distinct ferroptotic response during tumor suppression	162
A novel protein CYTB-187AA encoded by the mitochondrial gene CYTB modulates mammalian early development	161
STING orchestrates the crosstalk between polyunsaturated fatty acid metabolism and inflammatory responses	158
A microbial metabolite inhibits the HIF-2α-ceramide pathway to mediate the beneficial effects of time-restricted feeding on MASH	157
Defend or reproduce? Muscle-derived glutamate determines an immune-reproductive energetic tradeoff	155
Focus on diet and exercise	153
Paraventricular glia drive circuit function to control metabolism	153
Excess pancreatic elastase alters acinar-β cell communication by impairing the mechano-signaling and the PAR2 pathways	152
Di-methylation of CD147-K234 Promotes the Progression of NSCLC by Enhancing Lactate Export	148
Targeting PDAC metabolism: Environment determines what has GOT2 give	144
Bone marrow immune cells respond to fluctuating nutritional stress to constrain weight regain	144
HNF1A and A1CF coordinate a beta cell transcription-splicing axis that is disrupted in type 2 diabetes	142
Understanding the metabolism of infants using whole-body metabolic models	138
Testing the carbohydrate-insulin model: Short-term metabolic responses to consumption of meals with varying glycemic index in healthy adults	137
EHBP1 suppresses liver fibrosis in metabolic dysfunction-associated steatohepatitis	136
MGAT2 inhibitor decreases liver fibrosis and inflammation in murine NASH models and reduces body weight in human adults with obesity	134
Maternal circadian rhythms during pregnancy dictate metabolic plasticity in offspring	132
Localized GLP1 receptor pre-internalization directs pancreatic alpha cell to beta cell communication	130
Early prediction of incident liver disease using conventional risk factors and gut-microbiome-augmented gradient boosting	130
The crosstalk between bone remodeling and energy metabolism: A translational perspective	130
PDIA3 defines a novel subset of adipose macrophages to exacerbate the development of obesity and metabolic disorders	130
Glutamate metabolism directs energetic trade-offs to shape host-pathogen susceptibility in Drosophila	129
Organ-specific fuel rewiring in acute and chronic hypoxia redistributes glucose and fatty acid metabolism	128
Effect of alternate day fasting combined with aerobic exercise on non-alcoholic fatty liver disease: A randomized controlled trial	128
The past, present, and future physiology and pharmacology of glucagon	126
Molecular mechanisms of snoRNA-IL-15 crosstalk in adipocyte lipolysis and NK cell rejuvenation	125
Amino acid is a major carbon source for hepatic lipogenesis	121
Evaluating human genetic support for hypothesized metabolic disease genes	121
Aerobic glycolysis promotes tumor immune evasion by hexokinase2-mediated phosphorylation of IκBα	120
Exosomal miR-302b rejuvenates aging mice by reversing the proliferative arrest of senescent cells	120
Exosomes as mediators of intercellular crosstalk in metabolism	118
Response to Paik et al. on the disease burden of NAFLD	114
Famsin and fasting adaptation: A glucagon connection	112
Biting into a union of oncology and metabolism through leukemic stem cells	112
Liver microbes controlling immunity: Facts and pitfalls	110
“Shunt-ing” down obesity with novel endogenous metabolites	110
A key role of PIEZO2 mechanosensitive ion channel in adipose sensory innervation	109
Anti-seizure effects of norepinephrine-induced free fatty acid release	108
Microbiome-derived metabolites counteract tumor-induced immunosuppression and boost immune checkpoint blockade	107
Beggars banquet: Metabolism in the tumor immune microenvironment and cancer therapy	106

Dietary-timing-induced gut microbiota diurnal oscillations modulate inflammatory rhythms in rheumatoid arthritis	105
Cardiometabolic health improvements upon dietary intervention are driven by tissue-specific insulin resistance phenotype: A precision nutrition trial	105
Effects on weight loss and glycemic control with SAR441255, a potent unimolecular peptide GLP-1/GIP/GCG receptor triagonist	104
Understanding the variation in exercise responses to guide personalized physical activity prescriptions	103
Acetate enables metabolic fitness and cognitive performance during sleep disruption	101
Obesity-associated microglial inflammatory activation paradoxically improves glucose tolerance	101
Targeting gut microbial nitrogen recycling and cellular uptake of ammonium to improve bortezomib resistance in multiple myeloma	100
Single-cell transcriptomic and spatial landscapes of the developing human pancreas	99
Cancer cells co-opt nociceptive nerves to thrive in nutrient-poor environments and upon nutrient-starvation therapies	97
Psychological stress-induced microbial metabolite indole-3-acetate disrupts intestinal cell lineage commitment	96
Tumor-associated macrophages are shaped by intratumoral high potassium via Kir2.1	96
Microglial lipid droplet accumulation in tauopathy brain is regulated by neuronal AMPK	94
Extracellular vesicles in fatty liver promote a metastatic tumor microenvironment	93
Lactobacillus plantarum-derived indole-3-lactic acid ameliorates colorectal tumorigenesis via epigenetic regulation of CD8+ T cell immunity	92
Linoleic acid potentiates CD8+ T cell metabolic fitness and antitumor immunity	92
Emerging therapies in cancer metabolism	92