OOIR: Observatory of International Research

Papers

(The H4-Index of Cell Metabolism is 95. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-04-01 to 2025-04-01.)

Article	Citations
Metabolic set points of mammalian neurodevelopment	740
Metabolic elasticity: A new measure of age	590
Early downmodulation of tumor glycolysis predicts response to fasting-mimicking diet in triple-negative breast cancer patients	443
Disrupted methionine cycle triggers muscle atrophy in cancer cachexia through epigenetic regulation of REDD1	442
MARIGOLD and MitoCIAO, two searchable compendia to visualize and functionalize protein complexes during mitochondrial remodeling	417
Formation of I2+III2 supercomplex rescues respiratory chain defects	382
Itaconate boosts malaria via induction of PD-L1	366
The Achilles heel of TNBCs: Ferroptosis heterogeneity	346
Secreted phospholipase A2 modifies extracellular vesicles and accelerates B cell lymphoma	338
Erythrocyte-derived mitochondria take to the lupus stage	327
Walking the high wire: How neurons maintain stability in the crossline of neurodegeneration	316
Transient Receptor Potential V Channels Are Essential for Glucose Sensing by Aldolase and AMPK	303
Development of a functional beige fat cell line uncovers independent subclasses of cells expressing UCP1 and the futile creatine cycle	303
GDF15 is a major determinant of ketogenic diet-induced weight loss	289
PKD1 mutant clones within cirrhotic livers inhibit steatohepatitis without promoting cancer	285
A hypometabolic defense strategy against malaria	279
Diabesity? No worries, FKBP11 to the rescue	279
Insulin: A GOAT of medical discovery	274
CoAching CD8+ T cells for tumor immunotherapy—the pantothenate way	270
SARS-CoV-2 pirates the kidneys: A scar(y) story	260
Tirzepatide modulates the regulation of adipocyte nutrient metabolism through long-acting activation of the GIP receptor	256
Nourishing the mind: Fasting for brain health	243
Ketogenesis promotes tolerance to Pseudomonas aeruginosa pulmonary infection	241
Microbial-host isozyme: A novel target in “drug the bug” strategies for diabetes	227
A dietary source of antibiotic tolerance	210

What we talk about when we talk about spinal cord aging	204
Judith Campisi (1948–2024)	203
Nutrients in the fate of pluripotent stem cells	200
Meet the author: Professor Zhijian Cai	197
Methionine restriction forces Epstein-Barr virus out of latency	196
The search for thermoregulatory neurons is heating up	187
Krebs takes a turn at cell differentiation	184
Glycolysis-derived L-serine levels versus PHGDH expression in Alzheimer’s disease	183
Outrunning obesity with Lac-Phe?	182
Central inhibition of HDAC6 re-sensitizes leptin signaling during obesity to induce profound weight loss	182
Glucagon promotes increased hepatic mitochondrial oxidation and pyruvate carboxylase flux in humans with fatty liver disease	179
Bempedoic acid suppresses diet-induced hepatic steatosis independently of ATP-citrate lyase	178
Bone marrow immune cells stop weight regain	178
Gene-metabolite linkage marks stored red blood cell quality	175
Dietary-timing-induced gut microbiota diurnal oscillations modulate inflammatory rhythms in rheumatoid arthritis	169
Prevention of cardiorenal complications in people with type 2 diabetes and obesity	168
All hands on deck: Adipocytes lept-in to drive nerve regeneration	163
DMHPpp1r17 neurons regulate aging and lifespan in mice through hypothalamic-adipose inter-tissue communication	162
Transforming the cardiometabolic disease landscape: Multimodal AI-powered approaches in prevention and management	161
The effects of pregnancy, its progression, and its cessation on human (maternal) biological aging	158
A new role for ammonia in tumorigenesis?	155
dNTP concentrations do not increase in mammalian cells in response to DNA damage	154
Immunotherapy breaches low-sugar dieting of tumor Treg cells	153
Midlobular zone 2 hepatocytes: A gatekeeper of liver homeostasis	153
Preoptic BRS3 neurons increase body temperature and heart rate via multiple pathways	150
Illuminating lactate in cells, mice, and patient samples	149
Cap CASP, not SCAP, to fight steatohepatitis	149
Fight, flight, and freeze!	141
Death-seq and ye shall find: A novel screening strategy for dying cells	139
Mitochondrial quality control: Just walk away	137
The secret life of lactate: A novel cell-cycle regulatory mechanism	136
Hunger potentiated	134
Sex- and timing-specific effects of fasting and caloric restriction	133
Spatial mapping reveals human adipocyte subpopulations with distinct sensitivities to insulin	133
Adolescent exposure to low-dose THC disrupts energy balance and adipose organ homeostasis in adulthood	133
Complementary lateral hypothalamic populations resist hunger pressure to balance nutritional and social needs	133
Dysregulated BH4 metabolism facilitates immunosuppression in pancreatic cancer	129
Lactate homeostasis is maintained through regulation of glycolysis and lipolysis	128
Direct and indirect control of hepatic glucose production by insulin	127
Unveiling adipose populations linked to metabolic health in obesity	122
Palmitoylation couples insulin hypersecretion with β cell failure in diabetes	121
Protein-metabolite association studies identify novel proteomic determinants of metabolite levels in human plasma	120
Food colorants metabolized by commensal bacteria promote colitis in mice with dysregulated expression of interleukin-23	119
Mechanoresponsive metabolism in cancer cell migration and metastasis	119
Regulatory T cells require IL6 receptor alpha signaling to control skeletal muscle function and regeneration	116
When a calorie is not just a calorie: Diet quality and timing as mediators of metabolism and healthy aging	114
A pattern emerges in chromatin aging: AP-1 steals the show	113
Gut microbial alterations in arginine metabolism determine bone mechanical adaptation	112
Integrative systems analysis identifies genetic and dietary modulators of bile acid homeostasis	112
Oxylipin-PPARγ-initiated adipocyte senescence propagates secondary senescence in the bone marrow	111

Glycine decarboxylase maintains mitochondrial protein lipoylation to support tumor growth	110
Evaluating the beneficial effects of dietary restrictions: A framework for precision nutrigeroscience	109
Exercise-induced angiogenesis is dependent on metabolically primed ATF3/4+ endothelial cells	109
Systems-level analysis of insulin action in mouse strains provides insight into tissue- and pathway-specific interactions that drive insulin resistance	109
Divergent roles for the gut intraepithelial lymphocyte GLP-1R in control of metabolism, microbiota, and T cell-induced inflammation	109
Sex and genetic background define the metabolic, physiologic, and molecular response to protein restriction	107
A mechanosensitive lipolytic factor in the bone marrow promotes osteogenesis and lymphopoiesis	105
Obesity disrupts the pituitary-hepatic UPR communication leading to NAFLD progression	105
Interferon-α-producing plasmacytoid dendritic cells drive the loss of adipose tissue regulatory T cells during obesity	105
Time-restricted eating and exercise training improve HbA1c and body composition in women with overweight/obesity: A randomized controlled trial	105
Quantitative high-confidence human mitochondrial proteome and its dynamics in cellular context	104
Electron transport chain inhibition increases cellular dependence on purine transport and salvage	103
Ketone flux through BDH1 supports metabolic remodeling of skeletal and cardiac muscles in response to intermittent time-restricted feeding	102
Single-cell dissection of the obesity-exercise axis in adipose-muscle tissues implies a critical role for mesenchymal stem cells	101
Exploratory physiological experiments are not clinical trials	100
CD36 maintains lipid homeostasis via selective uptake of monounsaturated fatty acids during matrix detachment and tumor progression	99
BefA, a microbiota-secreted membrane disrupter, disseminates to the pancreas and increases β cell mass	99
Exercise-activated hepatic autophagy via the FN1-α5β1 integrin pathway drives metabolic benefits of exercise	99
Discovering signaling mechanisms governing metabolism and metabolic diseases with Drosophila	97
Ergothioneine improves healthspan of aged animals by enhancing cGPDH activity through CSE-dependent persulfidation	97