OOIR: Observatory of International Research

Papers

(The H4-Index of Cell Metabolism is 92. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-08-01 to 2025-08-01.)

Article	Citations
Cap CASP, not SCAP, to fight steatohepatitis	879
Dopaminylation of endothelial TPI1 suppresses ferroptotic angiocrine signals to promote lung regeneration over fibrosis	553
Sex- and timing-specific effects of fasting and caloric restriction	526
The secret life of lactate: A novel cell-cycle regulatory mechanism	472
Development of a functional beige fat cell line uncovers independent subclasses of cells expressing UCP1 and the futile creatine cycle	472
Lysine acetyltransferase 6A maintains CD4+ T cell response via epigenetic reprogramming of glucose metabolism in autoimmunity	442
Association of genetic risk, lifestyle, and their interaction with obesity and obesity-related morbidities	407
Time-restricted eating and exercise training improve HbA1c and body composition in women with overweight/obesity: A randomized controlled trial	400
The Achilles heel of TNBCs: Ferroptosis heterogeneity	374
Unveiling adipose populations linked to metabolic health in obesity	365
The Type 2 Diabetes Knowledge Portal: An open access genetic resource dedicated to type 2 diabetes and related traits	360
Glucagon promotes increased hepatic mitochondrial oxidation and pyruvate carboxylase flux in humans with fatty liver disease	338
DMHPpp1r17 neurons regulate aging and lifespan in mice through hypothalamic-adipose inter-tissue communication	333
Metabolic switch regulates lineage plasticity and induces synthetic lethality in triple-negative breast cancer	331
Lactate homeostasis is maintained through regulation of glycolysis and lipolysis	324
Adipocyte iron levels impinge on a fat-gut crosstalk to regulate intestinal lipid absorption and mediate protection from obesity	318
“Sweet death”: Fructose as a metabolic toxin that targets the gut-liver axis	308
Sex and genetic background define the metabolic, physiologic, and molecular response to protein restriction	299
Microvessels enhance vascularization and function of transplanted insulin-producing cells	286
mTOR takes charge: Relaying uncharged tRNA levels by mTOR ubiquitination	251
Dynamic scRNA-seq of live human pancreatic slices reveals functional endocrine cell neogenesis through an intermediate ducto-acinar stage	246
Mitochondrial cristae-remodeling protein OPA1 in POMC neurons couples Ca2+ homeostasis with adipose tissue lipolysis	225
Spatial regulation of glucose and lipid metabolism by hepatic insulin signaling	223
Sugar addiction: An Achilles’ heel of auto-immune diseases?	220
Kir2.1 channel: Macrophage plasticity in tumor microenvironment	217

Metabolic regulation of the glioblastoma stem cell epitranscriptome by malate dehydrogenase 2	215
The integrated stress response fine-tunes stem cell fate decisions upon serine deprivation and tissue injury	209
A hierarchical hepatic de novo lipogenesis substrate supply network utilizing pyruvate, acetate, and ketones	204
The cephalic phase of insulin release is modulated by IL-1β	202
Mitochondrial membrane lipids in the regulation of bioenergetic flux	193
Fructose-1,6-bisphosphatase is a nonenzymatic safety valve that curtails AKT activation to prevent insulin hyperresponsiveness	192
PHLDA2-mediated phosphatidic acid peroxidation triggers a distinct ferroptotic response during tumor suppression	182
Supercharging cancer-fighting T cells with lithium carbonate	179
A novel protein CYTB-187AA encoded by the mitochondrial gene CYTB modulates mammalian early development	175
STING orchestrates the crosstalk between polyunsaturated fatty acid metabolism and inflammatory responses	174
PHGDH-mediated endothelial metabolism drives glioblastoma resistance to chimeric antigen receptor T cell immunotherapy	172
Metabolic adaptation supports enhanced macrophage efferocytosis in limited-oxygen environments	168
Sphingolipid metabolism controls mammalian heart regeneration	162
FXR activation protects against NAFLD via bile-acid-dependent reductions in lipid absorption	162
Isolation of extracellular fluids reveals novel secreted bioactive proteins from muscle and fat tissues	160
A microbial metabolite inhibits the HIF-2α-ceramide pathway to mediate the beneficial effects of time-restricted feeding on MASH	158
Testing the carbohydrate-insulin model: Short-term metabolic responses to consumption of meals with varying glycemic index in healthy adults	153
The crosstalk between bone remodeling and energy metabolism: A translational perspective	152
Evaluating human genetic support for hypothesized metabolic disease genes	152
MGAT2 inhibitor decreases liver fibrosis and inflammation in murine NASH models and reduces body weight in human adults with obesity	151
PDIA3 defines a novel subset of adipose macrophages to exacerbate the development of obesity and metabolic disorders	151
EHBP1 suppresses liver fibrosis in metabolic dysfunction-associated steatohepatitis	150
Understanding the metabolism of infants using whole-body metabolic models	149
Defend or reproduce? Muscle-derived glutamate determines an immune-reproductive energetic tradeoff	147
Paraventricular glia drive circuit function to control metabolism	142
Focus on diet and exercise	138
Targeting PDAC metabolism: Environment determines what has GOT2 give	138
Glutamate metabolism directs energetic trade-offs to shape host-pathogen susceptibility in Drosophila	136
Molecular mechanisms of snoRNA-IL-15 crosstalk in adipocyte lipolysis and NK cell rejuvenation	136
Excess pancreatic elastase alters acinar-β cell communication by impairing the mechano-signaling and the PAR2 pathways	132
Localized GLP1 receptor pre-internalization directs pancreatic alpha cell to beta cell communication	130
Early prediction of incident liver disease using conventional risk factors and gut-microbiome-augmented gradient boosting	129
Maternal circadian rhythms during pregnancy dictate metabolic plasticity in offspring	128
Organ-specific fuel rewiring in acute and chronic hypoxia redistributes glucose and fatty acid metabolism	128
Aerobic glycolysis promotes tumor immune evasion by hexokinase2-mediated phosphorylation of IκBα	127
Di-methylation of CD147-K234 Promotes the Progression of NSCLC by Enhancing Lactate Export	126
Effect of alternate day fasting combined with aerobic exercise on non-alcoholic fatty liver disease: A randomized controlled trial	125
Exosomal miR-302b rejuvenates aging mice by reversing the proliferative arrest of senescent cells	124
Amino acid is a major carbon source for hepatic lipogenesis	123
Bone marrow immune cells respond to fluctuating nutritional stress to constrain weight regain	121
The past, present, and future physiology and pharmacology of glucagon	121
Exosomes as mediators of intercellular crosstalk in metabolism	120
Response to Paik et al. on the disease burden of NAFLD	119
Famsin and fasting adaptation: A glucagon connection	117
Biting into a union of oncology and metabolism through leukemic stem cells	117
“Shunt-ing” down obesity with novel endogenous metabolites	116
Liver microbes controlling immunity: Facts and pitfalls	115
Dietary-timing-induced gut microbiota diurnal oscillations modulate inflammatory rhythms in rheumatoid arthritis	112
A key role of PIEZO2 mechanosensitive ion channel in adipose sensory innervation	111
Anti-seizure effects of norepinephrine-induced free fatty acid release	108

Microbiome-derived metabolites counteract tumor-induced immunosuppression and boost immune checkpoint blockade	107
Acetate enables metabolic fitness and cognitive performance during sleep disruption	104
Obesity-associated microglial inflammatory activation paradoxically improves glucose tolerance	104
Targeting gut microbial nitrogen recycling and cellular uptake of ammonium to improve bortezomib resistance in multiple myeloma	103
Deciphering the metabolic heterogeneity of hematopoietic stem cells with single-cell resolution	103
Tumor-associated macrophages are shaped by intratumoral high potassium via Kir2.1	103
Cardiometabolic health improvements upon dietary intervention are driven by tissue-specific insulin resistance phenotype: A precision nutrition trial	102
Beggars banquet: Metabolism in the tumor immune microenvironment and cancer therapy	102
Single-cell transcriptomic and spatial landscapes of the developing human pancreas	101
Cardiovascular disease in diabetes, beyond glucose	101
Extracellular vesicles in fatty liver promote a metastatic tumor microenvironment	100
Effects on weight loss and glycemic control with SAR441255, a potent unimolecular peptide GLP-1/GIP/GCG receptor triagonist	98
Cancer cells co-opt nociceptive nerves to thrive in nutrient-poor environments and upon nutrient-starvation therapies	96
Glycometabolic reprogramming-induced XRCC1 lactylation confers therapeutic resistance in ALDH1A3-overexpressing glioblastoma	96
Understanding the variation in exercise responses to guide personalized physical activity prescriptions	95
Psychological stress-induced microbial metabolite indole-3-acetate disrupts intestinal cell lineage commitment	94
Lactobacillus plantarum-derived indole-3-lactic acid ameliorates colorectal tumorigenesis via epigenetic regulation of CD8+ T cell immunity	93