Cell Metabolism

Article	Citations
The secret life of lactate: A novel cell-cycle regulatory mechanism	796
Association of genetic risk, lifestyle, and their interaction with obesity and obesity-related morbidities	693
The Achilles heel of TNBCs: Ferroptosis heterogeneity	657
DGAT-driven futile lipid cycling has a pronounced, yet concealed, thermogenic function	539
Development of a functional beige fat cell line uncovers independent subclasses of cells expressing UCP1 and the futile creatine cycle	509
Unveiling adipose populations linked to metabolic health in obesity	497
Breath volatilome as a non-invasive reflection of gut microbiota-driven health and disease	471
The Type 2 Diabetes Knowledge Portal: An open access genetic resource dedicated to type 2 diabetes and related traits	441
DMHPpp1r17 neurons regulate aging and lifespan in mice through hypothalamic-adipose inter-tissue communication	369
Dopaminylation of endothelial TPI1 suppresses ferroptotic angiocrine signals to promote lung regeneration over fibrosis	353
Lysine acetyltransferase 6A maintains CD4+ T cell response via epigenetic reprogramming of glucose metabolism in autoimmunity	318
Lactate homeostasis is maintained through regulation of glycolysis and lipolysis	293
Time-restricted eating and exercise training improve HbA1c and body composition in women with overweight/obesity: A randomized controlled trial	280
Glucagon promotes increased hepatic mitochondrial oxidation and pyruvate carboxylase flux in humans with fatty liver disease	272
Cap CASP, not SCAP, to fight steatohepatitis	264
Sex- and timing-specific effects of fasting and caloric restriction	257
Adipocyte-derived extracellular vesicles are key regulators of central leptin sensitivity and energy homeostasis	241
Metabolic switch regulates lineage plasticity and induces synthetic lethality in triple-negative breast cancer	237
Sphingolipid metabolism controls mammalian heart regeneration	228
Supercharging cancer-fighting T cells with lithium carbonate	227
The integrated stress response fine-tunes stem cell fate decisions upon serine deprivation and tissue injury	220
Nutrient allocation fuels T cell-mediated immunity	205
mTOR takes charge: Relaying uncharged tRNA levels by mTOR ubiquitination	205
The cephalic phase of insulin release is modulated by IL-1β	200
Fructose-1,6-bisphosphatase is a nonenzymatic safety valve that curtails AKT activation to prevent insulin hyperresponsiveness	199

Isolation of extracellular fluids reveals novel secreted bioactive proteins from muscle and fat tissues	199
Metabolic regulation of the glioblastoma stem cell epitranscriptome by malate dehydrogenase 2	197
Illuminating the influence of natural daylight on human metabolism	193
Spatial regulation of glucose and lipid metabolism by hepatic insulin signaling	193
Polyunsaturated lipids kill senescent cells by ferroptosis	189
Plasma proteomic signature of frailty in 50,506 adults	188
PHLDA2-mediated phosphatidic acid peroxidation triggers a distinct ferroptotic response during tumor suppression	177
Deletion of Mfn2 in endothelial cells triggers a mitohormetic response that improves systemic metabolism and healthspan in mice	176
Dynamic scRNA-seq of live human pancreatic slices reveals functional endocrine cell neogenesis through an intermediate ducto-acinar stage	173
PHGDH-mediated endothelial metabolism drives glioblastoma resistance to chimeric antigen receptor T cell immunotherapy	172
Kir2.1 channel: Macrophage plasticity in tumor microenvironment	170
A novel protein CYTB-187AA encoded by the mitochondrial gene CYTB modulates mammalian early development	168
Metabolic adaptation supports enhanced macrophage efferocytosis in limited-oxygen environments	167
A hierarchical hepatic de novo lipogenesis substrate supply network utilizing pyruvate, acetate, and ketones	166
Mitochondrial membrane lipids in the regulation of bioenergetic flux	164
Excess pancreatic elastase alters acinar-β cell communication by impairing the mechano-signaling and the PAR2 pathways	163
Paraventricular glia drive circuit function to control metabolism	159
Focus on diet and exercise	158
Understanding the metabolism of infants using whole-body metabolic models	157
Targeting PDAC metabolism: Environment determines what has GOT2 give	155
A microbial metabolite inhibits the HIF-2α-ceramide pathway to mediate the beneficial effects of time-restricted feeding on MASH	152
HNF1A and A1CF coordinate a beta cell transcription-splicing axis that is disrupted in type 2 diabetes	152
Testing the carbohydrate-insulin model: Short-term metabolic responses to consumption of meals with varying glycemic index in healthy adults	149
Digital twins for in vivo metabolic flux estimations in patients with brain cancer	148
Di-methylation of CD147-K234 Promotes the Progression of NSCLC by Enhancing Lactate Export	146
The crosstalk between bone remodeling and energy metabolism: A translational perspective	144
Evaluating human genetic support for hypothesized metabolic disease genes	144
Lipid droplet-induced T cell death sustains autoimmune tissue inflammation	142
Early prediction of incident liver disease using conventional risk factors and gut-microbiome-augmented gradient boosting	141
Exercise as a therapeutic intervention for long-lasting and chronic diseases	129
Localized GLP1 receptor pre-internalization directs pancreatic alpha cell to beta cell communication	126
Molecular mechanisms of snoRNA-IL-15 crosstalk in adipocyte lipolysis and NK cell rejuvenation	126
The gut microbiota alleviates depression by remodeling gut-brain energy metabolism	124
Effect of alternate day fasting combined with aerobic exercise on non-alcoholic fatty liver disease: A randomized controlled trial	123
EHBP1 suppresses liver fibrosis in metabolic dysfunction-associated steatohepatitis	122
PDIA3 defines a novel subset of adipose macrophages to exacerbate the development of obesity and metabolic disorders	122
Organ-specific fuel rewiring in acute and chronic hypoxia redistributes glucose and fatty acid metabolism	121
MGAT2 inhibitor decreases liver fibrosis and inflammation in murine NASH models and reduces body weight in human adults with obesity	121
Bone marrow immune cells respond to fluctuating nutritional stress to constrain weight regain	119
Red blood cells serve as a primary glucose sink to improve glucose tolerance at altitude	119
Exosomal miR-302b rejuvenates aging mice by reversing the proliferative arrest of senescent cells	118
Maternal circadian rhythms during pregnancy dictate metabolic plasticity in offspring	117
Amino acid is a major carbon source for hepatic lipogenesis	116
Aerobic glycolysis promotes tumor immune evasion by hexokinase2-mediated phosphorylation of IκBα	116
The past, present, and future physiology and pharmacology of glucagon	116
Response to Paik et al. on the disease burden of NAFLD	115
Biting into a union of oncology and metabolism through leukemic stem cells	115
Lighting up arginine metabolism reveals its functional diversity in physiology and pathology	115
Dietary methionine mitigates immune-mediated damage by enhancing renal clearance of cytokines	114
Obesity-associated microglial inflammatory activation paradoxically improves glucose tolerance	114

“Shunt-ing” down obesity with novel endogenous metabolites	113
Famsin and fasting adaptation: A glucagon connection	111
Dietary-timing-induced gut microbiota diurnal oscillations modulate inflammatory rhythms in rheumatoid arthritis	110
Microbiome-derived metabolites counteract tumor-induced immunosuppression and boost immune checkpoint blockade	110
DGAT-driven futile lipid cycling has a pronounced, yet concealed, thermogenic function	109
Emerging therapies in cancer metabolism	109
Extracellular vesicles in fatty liver promote a metastatic tumor microenvironment	109
Psychological stress-induced microbial metabolite indole-3-acetate disrupts intestinal cell lineage commitment	107
Beggars banquet: Metabolism in the tumor immune microenvironment and cancer therapy	107
Microglial lipid droplet accumulation in tauopathy brain is regulated by neuronal AMPK	106
Anti-seizure effects of norepinephrine-induced free fatty acid release	106
A key role of PIEZO2 mechanosensitive ion channel in adipose sensory innervation	105
Targeting gut microbial nitrogen recycling and cellular uptake of ammonium to improve bortezomib resistance in multiple myeloma	105
Deciphering the metabolic heterogeneity of hematopoietic stem cells with single-cell resolution	105
Tumor-associated macrophages are shaped by intratumoral high potassium via Kir2.1	104
Lactobacillus plantarum-derived indole-3-lactic acid ameliorates colorectal tumorigenesis via epigenetic regulation of CD8+ T cell immunity	103
Single-cell transcriptomic and spatial landscapes of the developing human pancreas	99
Linoleic acid potentiates CD8+ T cell metabolic fitness and antitumor immunity	99
Cardiometabolic health improvements upon dietary intervention are driven by tissue-specific insulin resistance phenotype: A precision nutrition trial	98
Cancer cells co-opt nociceptive nerves to thrive in nutrient-poor environments and upon nutrient-starvation therapies	98
Glycometabolic reprogramming-induced XRCC1 lactylation confers therapeutic resistance in ALDH1A3-overexpressing glioblastoma	98
Mitochondrial lactate venting limits oxidative stress	98
Acetate enables metabolic fitness and cognitive performance during sleep disruption	97
Defying “IL-11ness” by inhibiting inflammation: Strategy for health and longevity	96
Dual targeting of SLC25A51 and succinate dehydrogenase selectively depletes mitochondrial NAD+ to eradicate KRAS-driven AML	96
Understanding the variation in exercise responses to guide personalized physical activity prescriptions	96
Glycerate from intestinal fructose metabolism induces islet cell damage and glucose intolerance	95
GDF15 enhances body weight and adiposity reduction in obese mice by leveraging the leptin pathway	94
Multi-organ transcriptome atlas of a mouse model of relative energy deficiency in sport	94
SLC25A48 controls mitochondrial choline import and metabolism	93
Hepatic malonyl-CoA synthesis restrains gluconeogenesis by suppressing fat oxidation, pyruvate carboxylation, and amino acid availability	93
A nutrigeroscience approach: Dietary macronutrients and cellular senescence	93
Regulatory T cells thrive in ammonia-rich tumors	93
Missed signals: How PET imaging may fail to capture the addictive potential of ultra-processed foods	93
Vitamin C slows primate aging by targeting iron-driven lipid peroxidation	93
Intracellular infection and immune system cues rewire adipocytes to acquire immune function	92
Fueling metabolic disruption via FMD to boost chemotherapy in TNBC	92
Vps37a regulates hepatic glucose production by controlling glucagon receptor localization to endosomes	92
Does sweet turn sour? How aspartame aggravates atherosclerosis in a preclinical model	92
Adipocyte-derived glutathione promotes obesity-related breast cancer by regulating the SCARB2-ARF1-mTORC1 complex	91
The tRNA-GCN2-FBXO22-axis-mediated mTOR ubiquitination senses amino acid insufficiency	91
The gut microbiota shapes the human and murine breath volatilome	90
Urea cycle activation triggered by host-microbiota maladaptation driving colorectal tumorigenesis	89
Hierarchical tricarboxylic acid cycle regulation by hepatocyte arginase 2 links the urea cycle to oxidative metabolism	89
Human genetics identify convergent signals in mitochondrial LACTB-mediated lipid metabolism in cardiovascular-kidney-metabolic syndrome	89
Diabetic retinopathy is a ceramidopathy reversible by anti-ceramide immunotherapy	88
Integrative genetic analysis identifies FLVCR1 as a plasma-membrane choline transporter in mammals	88
OMA1-mediated integrated stress response protects against ferroptosis in mitochondrial cardiomyopathy	88
The intersection of frailty and metabolism	87
Timed feeding aligns the adipocyte clock to optimize thermogenesis when eating a high-fat diet	87
Dietary timing enhances exercise by modulating fat-muscle crosstalk via adipocyte AMPKα2 signaling	87
Branching out beyond canonical brown adipocyte function	87
Not so neutral lipids: Metabolic regulation of the pre-metastatic niche	86
Intermittent fasting boosts sexual behavior by limiting the central availability of tryptophan and serotonin	85
Vive la resistant starch: A potential treatment for metabolic dysfunction-associated steatohepatitis	85
NAD depletion in skeletal muscle does not compromise muscle function or accelerate aging	84
Scale-spanning crosstalk between metabolism and information processing	84
The NARly side of whole-body NAD homeostasis	84
Extracellular vesicles from obese visceral adipose promote pancreatic cancer development and resistance to immune checkpoint blockade therapy	83
Liver mitochondrial cristae organizing protein MIC19 promotes energy expenditure and pedestrian locomotion by altering nucleotide metabolism	83
Back to basics: Bile acids in fat absorption	83
Preventing metabolic disease: Part I	82
Downregulation of the kidney glucagon receptor, essential for renal function and systemic homeostasis, contributes to chronic kidney disease	82
Pyruvate kinase M2 activation reprograms mitochondria in CD8 T cells, enhancing effector functions and efficacy of anti-PD1 therapy	81
Sensing steroid hormone 17α-hydroxypregnenolone by GPR56 enables protection from ferroptosis-induced liver injury	81
Age-related ciliopathy: Obesogenic shortening of melanocortin-4 receptor-bearing neuronal primary cilia	81
Cytosolic pH is a direct nexus in linking environmental cues with insulin processing and secretion in pancreatic β cells	81
Integrating multiplex immunofluorescent and mass spectrometry imaging to map myeloid heterogeneity in its metabolic and cellular context	80
Realigned transsulfuration drives BRAF-V600E-targeted therapy resistance in melanoma	80
NAD depletion in skeletal muscle does not compromise muscle function or accelerate aging	80
Body-wide multi-omic counteraction of aging with GLP-1R agonism	80
FGF21 reverses MASH through coordinated actions on the CNS and liver	80
Microbiota-gut-brain axis drives overeating disorders	80
Macrophage PD-1 regulates energy expenditure and metabolic dysfunction under immune checkpoint blockade	78
Hepatocyte CHRNA4 mediates the MASH-promotive effects of immune cell-produced acetylcholine and smoking exposure in mice and humans	77
Extracellular vesicles mediate the communication of adipose tissue with brain and promote cognitive impairment associated with insulin resistance	77
Two independent respiratory chains adapt OXPHOS performance to glycolytic switch	77
Unlocking the power of postbiotics: A revolutionary approach to nutrition for humans and animals	77
Maltol induces diabetic fragility fractures by disrupting the balance of bone remodeling	76
Paternal exercise confers endurance capacity to offspring through sperm microRNAs	76

Krebs takes a turn at cell differentiation	76
LY3437943, a novel triple glucagon, GIP, and GLP-1 receptor agonist for glycemic control and weight loss: From discovery to clinical proof of concept	76
Fight, flight, and freeze!	76
NRF2 activation induces NADH-reductive stress, providing a metabolic vulnerability in lung cancer	76
Outrunning obesity with Lac-Phe?	75
How to train your rodent: Recommendations for the preclinical study of exercise-induced benefits in metabolic research	75
A mechanosensitive lipolytic factor in the bone marrow promotes osteogenesis and lymphopoiesis	75
Genetics-nutrition interactions control diurnal enhancer-promoter dynamics and liver lipid metabolism	74
Diabesity? No worries, FKBP11 to the rescue	74
A pattern emerges in chromatin aging: AP-1 steals the show	74
Neutrophils resist ferroptosis and promote breast cancer metastasis through aconitate decarboxylase 1	73
Thymidine kinase 1 drives hepatocellular carcinoma in enzyme-dependent and -independent manners	73
Ergothioneine improves healthspan of aged animals by enhancing cGPDH activity through CSE-dependent persulfidation	73
Bempedoic acid suppresses diet-induced hepatic steatosis independently of ATP-citrate lyase	73
Gut microbial alterations in arginine metabolism determine bone mechanical adaptation	72
Comparative transcriptomics reveals circadian and pluripotency networks as two pillars of longevity regulation	72
Large-scale metaproteomics of human gut microbiota reveals microbial functions in metabolic diseases and aging	72
Purified diets enable experimental rigor through compositional control in animal research	71
Mitochondrial transfer from immune to tumor cells enables lymph node metastasis	71
Identification of a molecular resistor that controls UCP1-independent Ca2+ cycling thermogenesis in adipose tissue	71
Toward the next 20 years of Cell Metabolism	71
Dual inhibition of ACLY and ACSS2 by EVT0185 reduces steatosis, hepatic stellate cell activation, and fibrosis in mouse models of MASH	70
Targeting metabolic circuitry to supercharge CD8+ T cell antitumor responses	70
T-bet B or not T-bet B, is that the question in obesity-related metabolic disease?	70
m6A mRNA methylation in brown fat regulates systemic insulin sensitivity via an inter-organ prostaglandin signaling axis independent of UCP1	70
Inflammation and cholesterol at the crossroads of vascular risk	68
Hepatic FXR-FGF4 is required for bile acid homeostasis via an FGFR4-LRH-1 signal node under cholestatic stress	68
The neurocircuitry of fasting-induced glucocorticoid release	68
Short-term cold exposure induces persistent epigenomic memory in brown fat	67
A human omentum-specific mesothelial-like stromal population inhibits adipogenesis through IGFBP2 secretion	67
Warburg-like metabolic transformation underlies neuronal degeneration in sporadic Alzheimer’s disease	66
Immunoediting instructs tumor metabolic reprogramming to support immune evasion	65
Leptin enhances the intracellular thyroid hormone activation in skeletal muscle to boost energy balance	65
TM7SF3 controls TEAD1 splicing to prevent MASH-induced liver fibrosis	65
Itaconate transporter SLC13A3 confers immunotherapy resistance via alkylation-mediated stabilization of PD-L1	64
The mitochondrial multi-omic response to exercise training across rat tissues	64
Intermittent clearance of p21-highly-expressing cells extends lifespan and confers sustained benefits to health and physical function	64
Region-specific transcriptomic responses to obesity and diabetes in macaque hypothalamus	64
Mitochondrial isocitrate dehydrogenase impedes CAR T cell function by restraining antioxidant metabolism and histone acetylation	64
Elevated Hypothalamic TCPTP in Obesity Contributes to Cellular Leptin Resistance	63
Ketogenic diet promotes tumor ferroptosis but induces relative corticosterone deficiency that accelerates cachexia	63
Carbon source availability drives nutrient utilization in CD8+ T cells	63
Synergistic role of gut-microbial L-ornithine in enhancing ustekinumab efficacy for Crohn’s disease	63
Peter J. Roach (1948–2022)	62
Excessive vigorous exercise impairs cognitive function through a muscle-derived mitochondrial pretender	62
Stress-induced β cell early senescence confers protection against type 1 diabetes	62
FGF21 Prevents Angiotensin II-Induced Hypertension and Vascular Dysfunction by Activation of ACE2/Angiotensin-(1–7) Axis in Mice	62
Reassessment of antibody-based detection of the murine T cell GLP-1 receptor	62
Why timing matters in MASLD: Late-day metabolic control	62
On the mechanisms of ultra-processed diet effects	62
GDF15 analogs as obesity therapeutics	61
A microbial metabolite inhibits the HIF-2α-ceramide pathway to mediate the beneficial effects of time-restricted feeding on MASH	61
Gut enteroendocrine cell activation using a combination of GPR119 and GPR40 agonists results in synergistic hormone secretion in mice and humans	60
Transcriptomic, epigenomic, and spatial metabolomic cell profiling redefines regional human kidney anatomy	60
Ergothioneine controls mitochondrial function and exercise performance via direct activation of MPST	60
Non-invasive lipid panel of MASLD fibrosis transition underscores the role of lipoprotein sulfatides in hepatic immunomodulation	60
Circulating glycerate predicts resilience to fructose-induced hepatic steatosis	60
Acetate controls endothelial-to-mesenchymal transition	59
She didn’t start the fire: Mammary duct epithelial cells suppress adipocyte thermogenesis	59
Exercise induces tissue-specific adaptations to enhance cardiometabolic health	59
Time to exercise! Boosting exercise performance via AMPK signaling	58
Deoxyribonucleoside triphosphate pools in mammalian cells are expandable upon DNA damage	58
Leveraging genetic and phenotypic variation to discover metabolite-protein interactions	58
Protection from alcohol intoxication: Must be FGF21 to enter	57
Mitochondrial dysfunction reveals H2S-mediated synaptic sulfhydration as a potential mechanism for autism-associated social defects	56
Can we talk? The cryptic communications of hepatic stellate cells in lipid metabolism	56
The mitochondrial unfolded protein response regulates hippocampal neural stem cell aging	56
The DEAD Box Protein Mrh4 Functions in the Assembly of the Mitochondrial Large Ribosomal Subunit	56
Glycogen shepherd guides the hidden trail of pentose phosphate pathway	56
Comprehensive isotopomer analysis of glutamate and aspartate in small tissue samples	56
Separate gut-brain circuits for fat and sugar reinforcement combine to promote overeating	55
Klebsiella pneumoniae induces host metabolic stress that promotes tolerance to pulmonary infection	55
FKBP11 rewires UPR signaling to promote glucose homeostasis in type 2 diabetes and obesity	55
Cell Clustering Promotes a Metabolic Switch that Supports Metastatic Colonization	55
Imidazole propionate: Cause and cure in atherosclerosis?	55
SUCNR1 signaling in adipocytes controls energy metabolism by modulating circadian clock and leptin expression	55
The browning and mobilization of subcutaneous white adipose tissue supports efficient skin repair	54
Vps37a regulates hepatic glucose production by controlling glucagon receptor localization to endosomes	54
Mitohormesis	54
Molecular and metabolic heterogeneity of astrocytes and microglia	53
Physiologic disruption and metabolic reprogramming in infection and sepsis	53
Adipose whispers to mast cells for accelerating immune evasion in pancreatic cancer	53
Feasibility of time-restricted eating and impacts on cardiometabolic health in 24-h shift workers: The Healthy Heroes randomized control trial	53
Impact of biological sex and sex hormones on molecular signatures of skeletal muscle at rest and in response to distinct exercise training modes	53
NSUN2 is a glucose sensor suppressing cGAS/STING to maintain tumorigenesis and immunotherapy resistance	53
The effects of obesity and metabolic abnormalities on severe COVID-19-related outcomes after vaccination: A population-based study	52
Embracing the unknown: Proteomic insights into the human microbiome	52
Colonic macrophages eat and feed	52
Nicotinic acid riboside maintains NAD+ homeostasis and ameliorates aging-associated NAD+ decline	51
An “electric” microbial cue to control food intake behavior	51
SREBP1c-PARP1 axis tunes anti-senescence activity of adipocytes and ameliorates metabolic imbalance in obesity	51
Vitamin C inhibits ACSL4 to alleviate ferro-aging in primates	50
Hepatic lipid remodeling in cold exposure uncovers direct regulation of bis(monoacylglycero)phosphate lipids by phospholipase A2 group XV	50
Multi-omic human pancreatic islet endoplasmic reticulum and cytokine stress response mapping provides type 2 diabetes genetic insights	50
High dietary fructose promotes hepatocellular carcinoma progression by enhancing O-GlcNAcylation via microbiota-derived acetate	49