Cell Metabolism

Papers
(The median citation count of Cell Metabolism is 16. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2020-05-01 to 2024-05-01.)
ArticleCitations
Association of Blood Glucose Control and Outcomes in Patients with COVID-19 and Pre-existing Type 2 Diabetes1115
The Metabolic Underpinnings of Ferroptosis609
Elevated Glucose Levels Favor SARS-CoV-2 Infection and Monocyte Response through a HIF-1α/Glycolysis-Dependent Axis467
The hallmarks of cancer metabolism: Still emerging412
Benefits of Metformin in Attenuating the Hallmarks of Aging391
Omics-Driven Systems Interrogation of Metabolic Dysregulation in COVID-19 Pathogenesis376
In-Hospital Use of Statins Is Associated with a Reduced Risk of Mortality among Individuals with COVID-19375
CD36-mediated ferroptosis dampens intratumoral CD8+ T cell effector function and impairs their antitumor ability366
Mitochondrial Metabolism as a Target for Cancer Therapy334
Metformin Enhances Autophagy and Normalizes Mitochondrial Function to Alleviate Aging-Associated Inflammation324
The Role of HIF in Immunity and Inflammation317
The Immunomodulatory Metabolite Itaconate Modifies NLRP3 and Inhibits Inflammasome Activation296
Effects of 4- and 6-h Time-Restricted Feeding on Weight and Cardiometabolic Health: A Randomized Controlled Trial in Adults with Obesity283
Gut microbial metabolites facilitate anticancer therapy efficacy by modulating cytotoxic CD8+ T cell immunity276
Exosomes as mediators of intercellular crosstalk in metabolism265
Amino Assets: How Amino Acids Support Immunity262
The Gut Microbiota in Prediabetes and Diabetes: A Population-Based Cross-Sectional Study236
Defined p16High Senescent Cell Types Are Indispensable for Mouse Healthspan234
Endothelial Lactate Controls Muscle Regeneration from Ischemia by Inducing M2-like Macrophage Polarization227
SARS-CoV-2 infects human pancreatic β cells and elicits β cell impairment226
Metabolic-Pathway-Based Subtyping of Triple-Negative Breast Cancer Reveals Potential Therapeutic Targets223
Why does obesity cause diabetes?213
Tumor-derived exosomes drive immunosuppressive macrophages in a pre-metastatic niche through glycolytic dominant metabolic reprogramming206
SCENITH: A Flow Cytometry-Based Method to Functionally Profile Energy Metabolism with Single-Cell Resolution203
Alpha-Ketoglutarate, an Endogenous Metabolite, Extends Lifespan and Compresses Morbidity in Aging Mice202
Peroxidation of n-3 and n-6 polyunsaturated fatty acids in the acidic tumor environment leads to ferroptosis-mediated anticancer effects200
SGLT2 Inhibition Mediates Protection from Diabetic Kidney Disease by Promoting Ketone Body-Induced mTORC1 Inhibition198
Hyocholic acid species improve glucose homeostasis through a distinct TGR5 and FXR signaling mechanism193
The adverse metabolic effects of branched-chain amino acids are mediated by isoleucine and valine188
Human Brown Adipocyte Thermogenesis Is Driven by β2-AR Stimulation187
Patch-Seq Links Single-Cell Transcriptomes to Human Islet Dysfunction in Diabetes180
Microbiota-derived acetate enables the metabolic fitness of the brain innate immune system during health and disease180
The Power of Plasticity—Metabolic Regulation of Hepatic Stellate Cells178
Diabetes, obesity, metabolism, and SARS-CoV-2 infection: the end of the beginning178
FXR activation protects against NAFLD via bile-acid-dependent reductions in lipid absorption177
Changing global epidemiology of liver cancer from 2010 to 2019: NASH is the fastest growing cause of liver cancer177
Extracellular vesicle-based interorgan transport of mitochondria from energetically stressed adipocytes172
Plasticity of Epididymal Adipose Tissue in Response to Diet-Induced Obesity at Single-Nucleus Resolution170
Targeting DGAT1 Ameliorates Glioblastoma by Increasing Fat Catabolism and Oxidative Stress167
Positive feedback regulation of microglial glucose metabolism by histone H4 lysine 12 lactylation in Alzheimer’s disease165
Intercellular Mitochondria Transfer to Macrophages Regulates White Adipose Tissue Homeostasis and Is Impaired in Obesity164
Gut-Resident Lactobacilli Activate Hepatic Nrf2 and Protect Against Oxidative Liver Injury161
Quantitative Fluxomics of Circulating Metabolites157
The Gut Microbiota at the Service of Immunometabolism156
A Universal Gut-Microbiome-Derived Signature Predicts Cirrhosis153
Non-canonical Glutamate-Cysteine Ligase Activity Protects against Ferroptosis153
Astrocyte-neuron metabolic cooperation shapes brain activity150
Niacin Cures Systemic NAD+ Deficiency and Improves Muscle Performance in Adult-Onset Mitochondrial Myopathy146
Tumors exploit FTO-mediated regulation of glycolytic metabolism to evade immune surveillance143
MiR-690, an exosomal-derived miRNA from M2-polarized macrophages, improves insulin sensitivity in obese mice142
NAD+ Metabolism Maintains Inducible PD-L1 Expression to Drive Tumor Immune Evasion139
The pyruvate-lactate axis modulates cardiac hypertrophy and heart failure136
Gut-liver axis: Pathophysiological concepts and clinical implications135
SARS-CoV-2 Cell Entry Factors ACE2 and TMPRSS2 Are Expressed in the Microvasculature and Ducts of Human Pancreas but Are Not Enriched in β Cells135
The glucose-dependent insulinotropic polypeptide (GIP) regulates body weight and food intake via CNS-GIPR signaling134
The many actions of insulin in skeletal muscle, the paramount tissue determining glycemia132
Expression of SARS-CoV-2 Entry Factors in the Pancreas of Normal Organ Donors and Individuals with COVID-19131
Mitochondrial signal transduction129
Mechanoresponsive metabolism in cancer cell migration and metastasis128
The global burden of metabolic disease: Data from 2000 to 2019128
Hyperglycemia in acute COVID-19 is characterized by insulin resistance and adipose tissue infectivity by SARS-CoV-2127
Asparagine couples mitochondrial respiration to ATF4 activity and tumor growth125
The NADPARK study: A randomized phase I trial of nicotinamide riboside supplementation in Parkinson’s disease124
Bone Marrow Mesenchymal Stem Cells Support Acute Myeloid Leukemia Bioenergetics and Enhance Antioxidant Defense and Escape from Chemotherapy123
A High-Density Human Mitochondrial Proximity Interaction Network123
Quantitative high-confidence human mitochondrial proteome and its dynamics in cellular context122
Immunometabolism in the Single-Cell Era121
SARS-CoV-2 infection induces beta cell transdifferentiation119
Elevated Glucose Levels Favor SARS-CoV-2 Infection and Monocyte Response through a HIF-1α/Glycolysis-Dependent Axis118
Sphingolipids in metabolic disease: The good, the bad, and the unknown118
Excessive exercise training causes mitochondrial functional impairment and decreases glucose tolerance in healthy volunteers118
Cholesterol Stabilizes TAZ in Hepatocytes to Promote Experimental Non-alcoholic Steatohepatitis117
High-fiber diet mitigates maternal obesity-induced cognitive and social dysfunction in the offspring via gut-brain axis116
Ferroptosis heterogeneity in triple-negative breast cancer reveals an innovative immunotherapy combination strategy115
Glutathione Restricts Serine Metabolism to Preserve Regulatory T Cell Function114
Itaconate and itaconate derivatives target JAK1 to suppress alternative activation of macrophages114
Polycystic ovary syndrome is transmitted via a transgenerational epigenetic process113
Evolving concepts in NAD+ metabolism112
Metabolic flexibility determines human NK cell functional fate in the tumor microenvironment111
Metformin Is Associated with Higher Incidence of Acidosis, but Not Mortality, in Individuals with COVID-19 and Pre-existing Type 2 Diabetes111
Molecular aspects of fructose metabolism and metabolic disease110
Pseudomonas aeruginosa Utilizes Host-Derived Itaconate to Redirect Its Metabolism to Promote Biofilm Formation110
Small Extracellular Vesicles Have GST Activity and Ameliorate Senescence-Related Tissue Damage109
The microbial metabolite trimethylamine N-oxide promotes antitumor immunity in triple-negative breast cancer108
Insulin Treatment Is Associated with Increased Mortality in Patients with COVID-19 and Type 2 Diabetes108
KIM-1 mediates fatty acid uptake by renal tubular cells to promote progressive diabetic kidney disease108
Efferocytosis induces macrophage proliferation to help resolve tissue injury104
Metabolic orchestration of the wound healing response104
Aerobic glycolysis promotes tumor immune evasion by hexokinase2-mediated phosphorylation of IκBα103
Hypothalamic detection of macronutrients via multiple gut-brain pathways102
Developmental and Tumor Angiogenesis Requires the Mitochondria-Shaping Protein Opa1102
Oligodendrocytes Provide Antioxidant Defense Function for Neurons by Secreting Ferritin Heavy Chain100
Current Concepts, Opportunities, and Challenges of Gut Microbiome-Based Personalized Medicine in Nonalcoholic Fatty Liver Disease99
Cholesterol-induced toxicity: An integrated view of the role of cholesterol in multiple diseases99
Generation of a p16 Reporter Mouse and Its Use to Characterize and Target p16high Cells In Vivo98
The Nuclear Receptor ESRRA Protects from Kidney Disease by Coupling Metabolism and Differentiation98
Meta-hallmarks of aging and cancer97
Effects on weight loss and glycemic control with SAR441255, a potent unimolecular peptide GLP-1/GIP/GCG receptor triagonist96
The Evolving Landscape of Noncanonical Functions of Metabolic Enzymes in Cancer and Other Pathologies95
Ejection of damaged mitochondria and their removal by macrophages ensure efficient thermogenesis in brown adipose tissue95
The role of lipids in cancer progression and metastasis95
The probiotic L. casei Zhang slows the progression of acute and chronic kidney disease95
Cardiovascular disease in diabetes, beyond glucose94
Platelets Facilitate the Wound-Healing Capability of Mesenchymal Stem Cells by Mitochondrial Transfer and Metabolic Reprogramming94
Pyruvate Kinase Controls Signal Strength in the Insulin Secretory Pathway92
Spatial mapping reveals human adipocyte subpopulations with distinct sensitivities to insulin92
Atlas of exercise metabolism reveals time-dependent signatures of metabolic homeostasis92
Fecal microbiota transplantation in human metabolic diseases: From a murky past to a bright future?92
Mitochondria Define Intestinal Stem Cell Differentiation Downstream of a FOXO/Notch Axis90
The World Goes Bats: Living Longer and Tolerating Viruses89
Mitochondrial metabolism coordinates stage-specific repair processes in macrophages during wound healing88
Hypothalamic bile acid-TGR5 signaling protects from obesity88
Untangling Determinants of Enhanced Health and Lifespan through a Multi-omics Approach in Mice87
Warmth Prevents Bone Loss Through the Gut Microbiota87
Low-Dose Sorafenib Acts as a Mitochondrial Uncoupler and Ameliorates Nonalcoholic Steatohepatitis87
A Nutrient-Sensing Transition at Birth Triggers Glucose-Responsive Insulin Secretion87
A Membrane-Bound Diacylglycerol Species Induces PKCϵ-Mediated Hepatic Insulin Resistance86
Obesity Impairs Short-Term and Working Memory through Gut Microbial Metabolism of Aromatic Amino Acids85
Tumor cells dictate anti-tumor immune responses by altering pyruvate utilization and succinate signaling in CD8+ T cells85
Mapping the single-cell transcriptomic response of murine diabetic kidney disease to therapies85
FGF21 Signals to Glutamatergic Neurons in the Ventromedial Hypothalamus to Suppress Carbohydrate Intake84
Microbiota alterations in proline metabolism impact depression83
Gut-brain communication by distinct sensory neurons differently controls feeding and glucose metabolism82
Reductive TCA cycle metabolism fuels glutamine- and glucose-stimulated insulin secretion82
Oxylipin biosynthesis reinforces cellular senescence and allows detection of senolysis82
The phytochemical hyperforin triggers thermogenesis in adipose tissue via a Dlat-AMPK signaling axis to curb obesity82
LY3437943, a novel triple glucagon, GIP, and GLP-1 receptor agonist for glycemic control and weight loss: From discovery to clinical proof of concept82
Intestinal hypoxia-inducible factor 2α regulates lactate levels to shape the gut microbiome and alter thermogenesis82
Neutrophils Fuel Effective Immune Responses through Gluconeogenesis and Glycogenesis81
Mitochondrial Oxidative Damage Underlies Regulatory T Cell Defects in Autoimmunity81
NEAT1 is essential for metabolic changes that promote breast cancer growth and metastasis81
Pathological angiogenesis in retinopathy engages cellular senescence and is amenable to therapeutic elimination via BCL-xL inhibition80
Apaf-1 Pyroptosome Senses Mitochondrial Permeability Transition80
The Neutrophil-to-Lymphocyte Ratio Determines Clinical Efficacy of Corticosteroid Therapy in Patients with COVID-1979
The glucose transporter GLUT3 controls T helper 17 cell responses through glycolytic-epigenetic reprogramming79
GLP-1 Receptor Signaling in Astrocytes Regulates Fatty Acid Oxidation, Mitochondrial Integrity, and Function78
Toll-Like Receptors Induce Signal-Specific Reprogramming of the Macrophage Lipidome78
The Source of Glycolytic Intermediates in Mammalian Tissues78
Liver-fibrosis-activated transcriptional networks govern hepatocyte reprogramming and intra-hepatic communication77
C9orf72 regulates energy homeostasis by stabilizing mitochondrial complex I assembly77
CRISPR screens in physiologic medium reveal conditionally essential genes in human cells76
TMEM41B acts as an ER scramblase required for lipoprotein biogenesis and lipid homeostasis76
A genome-scale gain-of-function CRISPR screen in CD8 T cells identifies proline metabolism as a means to enhance CAR-T therapy76
Elevation of JAML Promotes Diabetic Kidney Disease by Modulating Podocyte Lipid Metabolism75
GDF-15 Neutralization Alleviates Platinum-Based Chemotherapy-Induced Emesis, Anorexia, and Weight Loss in Mice and Nonhuman Primates75
Adenosine/A2B Receptor Signaling Ameliorates the Effects of Aging and Counteracts Obesity75
Microbial Imidazole Propionate Affects Responses to Metformin through p38γ-Dependent Inhibitory AMPK Phosphorylation75
Sirt2 Inhibition Enhances Metabolic Fitness and Effector Functions of Tumor-Reactive T Cells75
Induction of a Timed Metabolic Collapse to Overcome Cancer Chemoresistance75
A kidney perspective on the mechanism of action of sodium glucose co-transporter 2 inhibitors73
NAD+ Regeneration Rescues Lifespan, but Not Ataxia, in a Mouse Model of Brain Mitochondrial Complex I Dysfunction73
Targeting p21Cip1 highly expressing cells in adipose tissue alleviates insulin resistance in obesity72
Senescent immune cells release grancalcin to promote skeletal aging71
Deletion of Fructokinase in the Liver or in the Intestine Reveals Differential Effects on Sugar-Induced Metabolic Dysfunction70
Obesity-associated hyperleptinemia alters the gliovascular interface of the hypothalamus to promote hypertension70
Adhesion-mediated mechanosignaling forces mitohormesis70
“Sweet death”: Fructose as a metabolic toxin that targets the gut-liver axis70
The mitochondrial pyruvate carrier regulates memory T cell differentiation and antitumor function70
A Cell-Autonomous Signature of Dysregulated Protein Phosphorylation Underlies Muscle Insulin Resistance in Type 2 Diabetes70
Receptor-Mediated ER Export of Lipoproteins Controls Lipid Homeostasis in Mice and Humans70
Fasting-mimicking diet blocks triple-negative breast cancer and cancer stem cell escape69
A Metabolic Roadmap for Somatic Stem Cell Fate68
Mechano-induced cell metabolism promotes microtubule glutamylation to force metastasis68
Increased fidelity of protein synthesis extends lifespan68
Functional Genomics In Vivo Reveal Metabolic Dependencies of Pancreatic Cancer Cells67
Glial Metabolic Rewiring Promotes Axon Regeneration and Functional Recovery in the Central Nervous System66
Global Burden of Disease Study 2019 suggests that metabolic risk factors are the leading drivers of the burden of ischemic heart disease66
Selenium mediates exercise-induced adult neurogenesis and reverses learning deficits induced by hippocampal injury and aging65
Inhibition of ATP-citrate lyase improves NASH, liver fibrosis, and dyslipidemia63
The role of hepatokines in NAFLD63
Biological age is increased by stress and restored upon recovery63
Direct and indirect control of hepatic glucose production by insulin63
Creatine promotes cancer metastasis through activation of Smad2/362
Creatine-mediated crosstalk between adipocytes and cancer cells regulates obesity-driven breast cancer62
Tryptophan metabolism in health and disease62
PKM2-dependent metabolic skewing of hepatic Th17 cells regulates pathogenesis of non-alcoholic fatty liver disease61
OMA1-mediated integrated stress response protects against ferroptosis in mitochondrial cardiomyopathy60
Feasibility of time-restricted eating and impacts on cardiometabolic health in 24-h shift workers: The Healthy Heroes randomized control trial60
Acetyl-CoA Synthetase 2: A Critical Linkage in Obesity-Induced Tumorigenesis in Myeloma60
Isthmin-1 is an adipokine that promotes glucose uptake and improves glucose tolerance and hepatic steatosis59
Distinct properties of adipose stem cell subpopulations determine fat depot-specific characteristics59
Glutamine Metabolism Controls Stem Cell Fate Reversibility and Long-Term Maintenance in the Hair Follicle59
Identification of an Anti-diabetic, Orally Available Small Molecule that Regulates TXNIP Expression and Glucagon Action58
TANK-Binding Kinase 1 Regulates the Localization of Acyl-CoA Synthetase ACSL1 to Control Hepatic Fatty Acid Oxidation58
Glutaminase inhibition impairs CD8 T cell activation in STK11-/Lkb1-deficient lung cancer58
Aberrant iron distribution via hepatocyte-stellate cell axis drives liver lipogenesis and fibrosis58
Warburg-like metabolic transformation underlies neuronal degeneration in sporadic Alzheimer’s disease57
Eliminate or reformulate ultra-processed foods? Biological mechanisms matter56
Circadian rhythms and the gut microbiome synchronize the host’s metabolic response to diet56
Glycerol-3-phosphate biosynthesis regenerates cytosolic NAD+ to alleviate mitochondrial disease55
Insulin action in adipocytes, adipose remodeling, and systemic effects55
Metabolic stress drives sympathetic neuropathy within the liver55
Extracellular vesicles mediate the communication of adipose tissue with brain and promote cognitive impairment associated with insulin resistance55
Ablation of Fat Cells in Adult Mice Induces Massive Bone Gain55
The Major Pre- and Postmenopausal Estrogens Play Opposing Roles in Obesity-Driven Mammary Inflammation and Breast Cancer Development55
Human skeletal muscle CD90+ fibro-adipogenic progenitors are associated with muscle degeneration in type 2 diabetic patients55
STING orchestrates the crosstalk between polyunsaturated fatty acid metabolism and inflammatory responses55
Obesity-Linked PPARγ S273 Phosphorylation Promotes Insulin Resistance through Growth Differentiation Factor 354
Carbon source availability drives nutrient utilization in CD8+ T cells53
Distinct iNKT Cell Populations Use IFNγ or ER Stress-Induced IL-10 to Control Adipose Tissue Homeostasis52
Mitohormesis in Hypothalamic POMC Neurons Mediates Regular Exercise-Induced High-Turnover Metabolism52
A cold-stress-inducible PERK/OGT axis controls TOM70-assisted mitochondrial protein import and cristae formation52
Metabolic cycles and signals for insulin secretion52
FBW7 Mediates Senescence and Pulmonary Fibrosis through Telomere Uncapping52
A methionine-Mettl3-N-methyladenosine axis promotes polycystic kidney disease52
Comprehensive single-cell transcriptional profiling defines shared and unique epithelial injury responses during kidney fibrosis52
Proteasome stress in skeletal muscle mounts a long-range protective response that delays retinal and brain aging52
Exposure to Static Magnetic and Electric Fields Treats Type 2 Diabetes51
Food colorants metabolized by commensal bacteria promote colitis in mice with dysregulated expression of interleukin-2351
Adipocyte iron levels impinge on a fat-gut crosstalk to regulate intestinal lipid absorption and mediate protection from obesity51
Serine metabolism antagonizes antiviral innate immunity by preventing ATP6V0d2-mediated YAP lysosomal degradation51
Succinyl-CoA Ligase Deficiency in Pro-inflammatory and Tissue-Invasive T Cells51
Central Ceramide Signaling Mediates Obesity-Induced Precocious Puberty50
Interferon-α-producing plasmacytoid dendritic cells drive the loss of adipose tissue regulatory T cells during obesity50
Local Mitochondrial ATP Production Regulates Endothelial Fatty Acid Uptake and Transport50
The thermogenic activity of adjacent adipocytes fuels the progression of ccRCC and compromises anti-tumor therapeutic efficacy49
Placental superoxide dismutase 3 mediates benefits of maternal exercise on offspring health49
Brain glycogen serves as a critical glucosamine cache required for protein glycosylation48
Microbial regulation of hexokinase 2 links mitochondrial metabolism and cell death in colitis47
Disulfiram Treatment Normalizes Body Weight in Obese Mice47
Linoleic acid potentiates CD8+ T cell metabolic fitness and antitumor immunity46
Sex and genetic background define the metabolic, physiologic, and molecular response to protein restriction46
IL-33 causes thermogenic failure in aging by expanding dysfunctional adipose ILC245
Discovering signaling mechanisms governing metabolism and metabolic diseases with Drosophila45
Dietary lipids inhibit mitochondria transfer to macrophages to divert adipocyte-derived mitochondria into the blood45
Aging Reprograms the Hematopoietic-Vascular Niche to Impede Regeneration and Promote Fibrosis45
Functional Genomics Identifies Metabolic Vulnerabilities in Pancreatic Cancer45
GCN2 inhibition sensitizes arginine-deprived hepatocellular carcinoma cells to senolytic treatment44
A diabetic milieu increases ACE2 expression and cellular susceptibility to SARS-CoV-2 infections in human kidney organoids and patient cells44
MiR-690 treatment causes decreased fibrosis and steatosis and restores specific Kupffer cell functions in NASH44
The crosstalk between bone remodeling and energy metabolism: A translational perspective44
Positive Reinforcing Mechanisms between GPR120 and PPARγ Modulate Insulin Sensitivity43
Intercellular Transmission of Hepatic ER Stress in Obesity Disrupts Systemic Metabolism43
A newly identified protein from Akkermansia muciniphila stimulates GLP-1 secretion43
Metabolic programs tailor T cell immunity in viral infection, cancer, and aging42
Defects in a liver-bone axis contribute to hepatic osteodystrophy disease progression42
FGF1 and insulin control lipolysis by convergent pathways42
Upregulation of Antioxidant Capacity and Nucleotide Precursor Availability Suffices for Oncogenic Transformation41
Effect of alternate day fasting combined with aerobic exercise on non-alcoholic fatty liver disease: A randomized controlled trial41
Multi-Tissue Acceleration of the Mitochondrial Phosphoenolpyruvate Cycle Improves Whole-Body Metabolic Health41
Late isocaloric eating increases hunger, decreases energy expenditure, and modifies metabolic pathways in adults with overweight and obesity40
A Universal Gut-Microbiome-Derived Signature Predicts Cirrhosis40
Exome Sequencing Identifies Genes and Gene Sets Contributing to Severe Childhood Obesity, Linking PHIP Variants to Repressed POMC Transcription40
Lactobacillus plantarum-derived indole-3-lactic acid ameliorates colorectal tumorigenesis via epigenetic regulation of CD8+ T cell immunity39
Pimozide Alleviates Hyperglycemia in Diet-Induced Obesity by Inhibiting Skeletal Muscle Ketone Oxidation39
Single-cell dissection of the obesity-exercise axis in adipose-muscle tissues implies a critical role for mesenchymal stem cells39
Lysosomal lipoprotein processing in endothelial cells stimulates adipose tissue thermogenic adaptation38
Heterogenous impairment of α cell function in type 2 diabetes is linked to cell maturation state38
DRAK2 aggravates nonalcoholic fatty liver disease progression through SRSF6-associated RNA alternative splicing38
Memory CD8+ T Cells Balance Pro- and Anti-inflammatory Activity by Reprogramming Cellular Acetate Handling at Sites of Infection38
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