Cell Metabolism

Article	Citations
Cap CASP, not SCAP, to fight steatohepatitis	879
Dopaminylation of endothelial TPI1 suppresses ferroptotic angiocrine signals to promote lung regeneration over fibrosis	553
Sex- and timing-specific effects of fasting and caloric restriction	526
Development of a functional beige fat cell line uncovers independent subclasses of cells expressing UCP1 and the futile creatine cycle	472
The secret life of lactate: A novel cell-cycle regulatory mechanism	472
Lysine acetyltransferase 6A maintains CD4+ T cell response via epigenetic reprogramming of glucose metabolism in autoimmunity	442
Association of genetic risk, lifestyle, and their interaction with obesity and obesity-related morbidities	407
Time-restricted eating and exercise training improve HbA1c and body composition in women with overweight/obesity: A randomized controlled trial	400
The Achilles heel of TNBCs: Ferroptosis heterogeneity	374
Unveiling adipose populations linked to metabolic health in obesity	365
The Type 2 Diabetes Knowledge Portal: An open access genetic resource dedicated to type 2 diabetes and related traits	360
Glucagon promotes increased hepatic mitochondrial oxidation and pyruvate carboxylase flux in humans with fatty liver disease	338
DMHPpp1r17 neurons regulate aging and lifespan in mice through hypothalamic-adipose inter-tissue communication	333
Metabolic switch regulates lineage plasticity and induces synthetic lethality in triple-negative breast cancer	331
Lactate homeostasis is maintained through regulation of glycolysis and lipolysis	324
Adipocyte iron levels impinge on a fat-gut crosstalk to regulate intestinal lipid absorption and mediate protection from obesity	318
“Sweet death”: Fructose as a metabolic toxin that targets the gut-liver axis	308
Sex and genetic background define the metabolic, physiologic, and molecular response to protein restriction	299
Microvessels enhance vascularization and function of transplanted insulin-producing cells	286
mTOR takes charge: Relaying uncharged tRNA levels by mTOR ubiquitination	251
Dynamic scRNA-seq of live human pancreatic slices reveals functional endocrine cell neogenesis through an intermediate ducto-acinar stage	246
Mitochondrial cristae-remodeling protein OPA1 in POMC neurons couples Ca2+ homeostasis with adipose tissue lipolysis	225
Spatial regulation of glucose and lipid metabolism by hepatic insulin signaling	223
Sugar addiction: An Achilles’ heel of auto-immune diseases?	220
Kir2.1 channel: Macrophage plasticity in tumor microenvironment	217

Metabolic regulation of the glioblastoma stem cell epitranscriptome by malate dehydrogenase 2	215
The integrated stress response fine-tunes stem cell fate decisions upon serine deprivation and tissue injury	209
A hierarchical hepatic de novo lipogenesis substrate supply network utilizing pyruvate, acetate, and ketones	204
The cephalic phase of insulin release is modulated by IL-1β	202
Mitochondrial membrane lipids in the regulation of bioenergetic flux	193
Fructose-1,6-bisphosphatase is a nonenzymatic safety valve that curtails AKT activation to prevent insulin hyperresponsiveness	192
PHLDA2-mediated phosphatidic acid peroxidation triggers a distinct ferroptotic response during tumor suppression	182
Supercharging cancer-fighting T cells with lithium carbonate	179
A novel protein CYTB-187AA encoded by the mitochondrial gene CYTB modulates mammalian early development	175
STING orchestrates the crosstalk between polyunsaturated fatty acid metabolism and inflammatory responses	174
PHGDH-mediated endothelial metabolism drives glioblastoma resistance to chimeric antigen receptor T cell immunotherapy	172
Metabolic adaptation supports enhanced macrophage efferocytosis in limited-oxygen environments	168
FXR activation protects against NAFLD via bile-acid-dependent reductions in lipid absorption	162
Sphingolipid metabolism controls mammalian heart regeneration	162
Isolation of extracellular fluids reveals novel secreted bioactive proteins from muscle and fat tissues	160
A microbial metabolite inhibits the HIF-2α-ceramide pathway to mediate the beneficial effects of time-restricted feeding on MASH	158
Testing the carbohydrate-insulin model: Short-term metabolic responses to consumption of meals with varying glycemic index in healthy adults	153
The crosstalk between bone remodeling and energy metabolism: A translational perspective	152
Evaluating human genetic support for hypothesized metabolic disease genes	152
PDIA3 defines a novel subset of adipose macrophages to exacerbate the development of obesity and metabolic disorders	151
MGAT2 inhibitor decreases liver fibrosis and inflammation in murine NASH models and reduces body weight in human adults with obesity	151
EHBP1 suppresses liver fibrosis in metabolic dysfunction-associated steatohepatitis	150
Understanding the metabolism of infants using whole-body metabolic models	149
Defend or reproduce? Muscle-derived glutamate determines an immune-reproductive energetic tradeoff	147
Paraventricular glia drive circuit function to control metabolism	142
Targeting PDAC metabolism: Environment determines what has GOT2 give	138
Focus on diet and exercise	138
Molecular mechanisms of snoRNA-IL-15 crosstalk in adipocyte lipolysis and NK cell rejuvenation	136
Glutamate metabolism directs energetic trade-offs to shape host-pathogen susceptibility in Drosophila	136
Excess pancreatic elastase alters acinar-β cell communication by impairing the mechano-signaling and the PAR2 pathways	132
Localized GLP1 receptor pre-internalization directs pancreatic alpha cell to beta cell communication	130
Early prediction of incident liver disease using conventional risk factors and gut-microbiome-augmented gradient boosting	129
Organ-specific fuel rewiring in acute and chronic hypoxia redistributes glucose and fatty acid metabolism	128
Maternal circadian rhythms during pregnancy dictate metabolic plasticity in offspring	128
Aerobic glycolysis promotes tumor immune evasion by hexokinase2-mediated phosphorylation of IκBα	127
Di-methylation of CD147-K234 Promotes the Progression of NSCLC by Enhancing Lactate Export	126
Effect of alternate day fasting combined with aerobic exercise on non-alcoholic fatty liver disease: A randomized controlled trial	125
Exosomal miR-302b rejuvenates aging mice by reversing the proliferative arrest of senescent cells	124
Amino acid is a major carbon source for hepatic lipogenesis	123
The past, present, and future physiology and pharmacology of glucagon	121
Bone marrow immune cells respond to fluctuating nutritional stress to constrain weight regain	121
Exosomes as mediators of intercellular crosstalk in metabolism	120
Response to Paik et al. on the disease burden of NAFLD	119
Famsin and fasting adaptation: A glucagon connection	117
Biting into a union of oncology and metabolism through leukemic stem cells	117
“Shunt-ing” down obesity with novel endogenous metabolites	116
Liver microbes controlling immunity: Facts and pitfalls	115
Dietary-timing-induced gut microbiota diurnal oscillations modulate inflammatory rhythms in rheumatoid arthritis	112
A key role of PIEZO2 mechanosensitive ion channel in adipose sensory innervation	111
Anti-seizure effects of norepinephrine-induced free fatty acid release	108

Microbiome-derived metabolites counteract tumor-induced immunosuppression and boost immune checkpoint blockade	107
Obesity-associated microglial inflammatory activation paradoxically improves glucose tolerance	104
Acetate enables metabolic fitness and cognitive performance during sleep disruption	104
Deciphering the metabolic heterogeneity of hematopoietic stem cells with single-cell resolution	103
Tumor-associated macrophages are shaped by intratumoral high potassium via Kir2.1	103
Targeting gut microbial nitrogen recycling and cellular uptake of ammonium to improve bortezomib resistance in multiple myeloma	103
Beggars banquet: Metabolism in the tumor immune microenvironment and cancer therapy	102
Cardiometabolic health improvements upon dietary intervention are driven by tissue-specific insulin resistance phenotype: A precision nutrition trial	102
Single-cell transcriptomic and spatial landscapes of the developing human pancreas	101
Cardiovascular disease in diabetes, beyond glucose	101
Extracellular vesicles in fatty liver promote a metastatic tumor microenvironment	100
Effects on weight loss and glycemic control with SAR441255, a potent unimolecular peptide GLP-1/GIP/GCG receptor triagonist	98
Glycometabolic reprogramming-induced XRCC1 lactylation confers therapeutic resistance in ALDH1A3-overexpressing glioblastoma	96
Cancer cells co-opt nociceptive nerves to thrive in nutrient-poor environments and upon nutrient-starvation therapies	96
Understanding the variation in exercise responses to guide personalized physical activity prescriptions	95
Psychological stress-induced microbial metabolite indole-3-acetate disrupts intestinal cell lineage commitment	94
Lactobacillus plantarum-derived indole-3-lactic acid ameliorates colorectal tumorigenesis via epigenetic regulation of CD8+ T cell immunity	93
Selenium mediates exercise-induced adult neurogenesis and reverses learning deficits induced by hippocampal injury and aging	91
Emerging therapies in cancer metabolism	90
Linoleic acid potentiates CD8+ T cell metabolic fitness and antitumor immunity	89
Microglial lipid droplet accumulation in tauopathy brain is regulated by neuronal AMPK	89
Defects in a liver-bone axis contribute to hepatic osteodystrophy disease progression	88
Defying “IL-11ness” by inhibiting inflammation: Strategy for health and longevity	87
FGF21 suppresses alcohol consumption through an amygdalo-striatal circuit	86
Urea cycle activation triggered by host-microbiota maladaptation driving colorectal tumorigenesis	86
Multi-organ transcriptome atlas of a mouse model of relative energy deficiency in sport	85
Combined glucocorticoid resistance and hyperlactatemia contributes to lethal shock in sepsis	85
GDF15 enhances body weight and adiposity reduction in obese mice by leveraging the leptin pathway	85
A nutrigeroscience approach: Dietary macronutrients and cellular senescence	84
Vps37a regulates hepatic glucose production by controlling glucagon receptor localization to endosomes	83
Fueling metabolic disruption via FMD to boost chemotherapy in TNBC	83
Glycerate from intestinal fructose metabolism induces islet cell damage and glucose intolerance	83
The Gro3p factor: Restoring NAD+/NADH homeostasis to ameliorate mitochondrial disease	82
Diabetic retinopathy is a ceramidopathy reversible by anti-ceramide immunotherapy	81
Human genetics identify convergent signals in mitochondrial LACTB-mediated lipid metabolism in cardiovascular-kidney-metabolic syndrome	80
The intersection of frailty and metabolism	79
Hierarchical tricarboxylic acid cycle regulation by hepatocyte arginase 2 links the urea cycle to oxidative metabolism	78
Does sweet turn sour? How aspartame aggravates atherosclerosis in a preclinical model	78
Integrative genetic analysis identifies FLVCR1 as a plasma-membrane choline transporter in mammals	77
Intracellular infection and immune system cues rewire adipocytes to acquire immune function	77
Hepatic malonyl-CoA synthesis restrains gluconeogenesis by suppressing fat oxidation, pyruvate carboxylation, and amino acid availability	76
The tRNA-GCN2-FBXO22-axis-mediated mTOR ubiquitination senses amino acid insufficiency	76
Dietary timing enhances exercise by modulating fat-muscle crosstalk via adipocyte AMPKα2 signaling	75
Adipocyte-derived glutathione promotes obesity-related breast cancer by regulating the SCARB2-ARF1-mTORC1 complex	75
OMA1-mediated integrated stress response protects against ferroptosis in mitochondrial cardiomyopathy	75
Timed feeding aligns the adipocyte clock to optimize thermogenesis when eating a high-fat diet	74
Molecular aspects of fructose metabolism and metabolic disease	74
Preventing metabolic disease: Part I	74
SLC25A48 controls mitochondrial choline import and metabolism	74
Not so neutral lipids: Metabolic regulation of the pre-metastatic niche	73
T cells critically depend on pyruvate oxidation	73
Realigned transsulfuration drives BRAF-V600E-targeted therapy resistance in melanoma	72
Branching out beyond canonical brown adipocyte function	72
Pyruvate kinase M2 activation reprograms mitochondria in CD8 T cells, enhancing effector functions and efficacy of anti-PD1 therapy	71
NAD depletion in skeletal muscle does not compromise muscle function or accelerate aging	71
The NARly side of whole-body NAD homeostasis	71
Intermittent fasting boosts sexual behavior by limiting the central availability of tryptophan and serotonin	70
Vive la resistant starch: A potential treatment for metabolic dysfunction-associated steatohepatitis	70
Age-related ciliopathy: Obesogenic shortening of melanocortin-4 receptor-bearing neuronal primary cilia	70
Microbiota-gut-brain axis drives overeating disorders	69
Liver mitochondrial cristae organizing protein MIC19 promotes energy expenditure and pedestrian locomotion by altering nucleotide metabolism	69
Metabolic programs tailor T cell immunity in viral infection, cancer, and aging	69
FGF21 reverses MASH through coordinated actions on the CNS and liver	69
Cytosolic pH is a direct nexus in linking environmental cues with insulin processing and secretion in pancreatic β cells	68
Targeting p21Cip1 highly expressing cells in adipose tissue alleviates insulin resistance in obesity	68
The thermogenic activity of adjacent adipocytes fuels the progression of ccRCC and compromises anti-tumor therapeutic efficacy	68
SARS-CoV-2 infects human pancreatic β cells and elicits β cell impairment	68
Integrating multiplex immunofluorescent and mass spectrometry imaging to map myeloid heterogeneity in its metabolic and cellular context	68
Two independent respiratory chains adapt OXPHOS performance to glycolytic switch	66
Unlocking the power of postbiotics: A revolutionary approach to nutrition for humans and animals	66
NRF2 activation induces NADH-reductive stress, providing a metabolic vulnerability in lung cancer	66
Extracellular vesicles mediate the communication of adipose tissue with brain and promote cognitive impairment associated with insulin resistance	66
Isthmin-1 is an adipokine that promotes glucose uptake and improves glucose tolerance and hepatic steatosis	65
Deoxyhypusine synthase promotes a pro-inflammatory macrophage phenotype	64
Hepatocyte CHRNA4 mediates the MASH-promotive effects of immune cell-produced acetylcholine and smoking exposure in mice and humans	64
Downregulation of the kidney glucagon receptor, essential for renal function and systemic homeostasis, contributes to chronic kidney disease	64
Fight, flight, and freeze!	63
A dietary source of antibiotic tolerance	63
LY3437943, a novel triple glucagon, GIP, and GLP-1 receptor agonist for glycemic control and weight loss: From discovery to clinical proof of concept	63
Diabesity? No worries, FKBP11 to the rescue	63

A pattern emerges in chromatin aging: AP-1 steals the show	63
The NADPARK study: A randomized phase I trial of nicotinamide riboside supplementation in Parkinson’s disease	62
Ergothioneine improves healthspan of aged animals by enhancing cGPDH activity through CSE-dependent persulfidation	62
Bempedoic acid suppresses diet-induced hepatic steatosis independently of ATP-citrate lyase	62
Outrunning obesity with Lac-Phe?	61
Krebs takes a turn at cell differentiation	61
Neutrophils resist ferroptosis and promote breast cancer metastasis through aconitate decarboxylase 1	60
Tumor-derived exosomes drive immunosuppressive macrophages in a pre-metastatic niche through glycolytic dominant metabolic reprogramming	60
A mechanosensitive lipolytic factor in the bone marrow promotes osteogenesis and lymphopoiesis	60
Gut microbial alterations in arginine metabolism determine bone mechanical adaptation	60
Thymidine kinase 1 drives hepatocellular carcinoma in enzyme-dependent and -independent manners	60
Targeting metabolic circuitry to supercharge CD8+ T cell antitumor responses	59
The neurocircuitry of fasting-induced glucocorticoid release	59
Synergistic role of gut-microbial L-ornithine in enhancing ustekinumab efficacy for Crohn’s disease	59
Carbon source availability drives nutrient utilization in CD8+ T cells	59
TOX4, an insulin receptor-independent regulator of hepatic glucose production, is activated in diabetic liver	59
m6A mRNA methylation in brown fat regulates systemic insulin sensitivity via an inter-organ prostaglandin signaling axis independent of UCP1	59
Inflammation and cholesterol at the crossroads of vascular risk	58
Leptin enhances the intracellular thyroid hormone activation in skeletal muscle to boost energy balance	58
First we eat, then we do everything else: The dynamic metabolic regulation of efferocytosis	58
A human omentum-specific mesothelial-like stromal population inhibits adipogenesis through IGFBP2 secretion	57
Identification of a molecular resistor that controls UCP1-independent Ca2+ cycling thermogenesis in adipose tissue	57
Intermittent clearance of p21-highly-expressing cells extends lifespan and confers sustained benefits to health and physical function	57
Comparative transcriptomics reveals circadian and pluripotency networks as two pillars of longevity regulation	57
T-bet B or not T-bet B, is that the question in obesity-related metabolic disease?	57
Short-term cold exposure induces persistent epigenomic memory in brown fat	57
TM7SF3 controls TEAD1 splicing to prevent MASH-induced liver fibrosis	56
Itaconate transporter SLC13A3 confers immunotherapy resistance via alkylation-mediated stabilization of PD-L1	56
Mitochondrial metabolism coordinates stage-specific repair processes in macrophages during wound healing	55
GLP-1/GIP/glucagon receptor triagonism gets its try in humans	55
Hepatic FXR-FGF4 is required for bile acid homeostasis via an FGFR4-LRH-1 signal node under cholestatic stress	55
Warburg-like metabolic transformation underlies neuronal degeneration in sporadic Alzheimer’s disease	54
Heterogenous impairment of α cell function in type 2 diabetes is linked to cell maturation state	54
The mitochondrial multi-omic response to exercise training across rat tissues	54
Mitochondrial isocitrate dehydrogenase impedes CAR T cell function by restraining antioxidant metabolism and histone acetylation	53
Region-specific transcriptomic responses to obesity and diabetes in macaque hypothalamus	53
Ketogenic diet promotes tumor ferroptosis but induces relative corticosterone deficiency that accelerates cachexia	53
Peter J. Roach (1948–2022)	52
Circulating glycerate predicts resilience to fructose-induced hepatic steatosis	52
Elevated Hypothalamic TCPTP in Obesity Contributes to Cellular Leptin Resistance	52
GDF15 analogs as obesity therapeutics	52
Immunoediting instructs tumor metabolic reprogramming to support immune evasion	52
Making a sPLAsh: The expanding repertoire of EV signaling	52
Stress-induced β cell early senescence confers protection against type 1 diabetes	50
Transcriptomic, epigenomic, and spatial metabolomic cell profiling redefines regional human kidney anatomy	50
Acetate controls endothelial-to-mesenchymal transition	50
Non-invasive lipid panel of MASLD fibrosis transition underscores the role of lipoprotein sulfatides in hepatic immunomodulation	50
A microbial metabolite inhibits the HIF-2α-ceramide pathway to mediate the beneficial effects of time-restricted feeding on MASH	50
Ergothioneine controls mitochondrial function and exercise performance via direct activation of MPST	50
Glucocorticoid resistance and hyperlactatemia: A tag team to worsen sepsis	49
She didn’t start the fire: Mammary duct epithelial cells suppress adipocyte thermogenesis	49
Protection from alcohol intoxication: Must be FGF21 to enter	49
Exercise induces tissue-specific adaptations to enhance cardiometabolic health	49
Deoxyribonucleoside triphosphate pools in mammalian cells are expandable upon DNA damage	49
Vps37a regulates hepatic glucose production by controlling glucagon receptor localization to endosomes	49
Eliminate or reformulate ultra-processed foods? Biological mechanisms matter	49
Microbiota-derived acetate enables the metabolic fitness of the brain innate immune system during health and disease	49
The DEAD Box Protein Mrh4 Functions in the Assembly of the Mitochondrial Large Ribosomal Subunit	49
Comprehensive isotopomer analysis of glutamate and aspartate in small tissue samples	48
Separate gut-brain circuits for fat and sugar reinforcement combine to promote overeating	48
Individual-specific functional epigenomics reveals genetic determinants of adverse metabolic effects of glucocorticoids	48
Klebsiella pneumoniae induces host metabolic stress that promotes tolerance to pulmonary infection	48
Can we talk? The cryptic communications of hepatic stellate cells in lipid metabolism	48
Mitohormesis	48
Time to exercise! Boosting exercise performance via AMPK signaling	48
The browning and mobilization of subcutaneous white adipose tissue supports efficient skin repair	47
Feasibility of time-restricted eating and impacts on cardiometabolic health in 24-h shift workers: The Healthy Heroes randomized control trial	47
A distinct hypothalamus-to-β cell circuit modulates insulin secretion	47
FKBP11 rewires UPR signaling to promote glucose homeostasis in type 2 diabetes and obesity	47
A purine metabolic checkpoint that prevents autoimmunity and autoinflammation	47
NSUN2 is a glucose sensor suppressing cGAS/STING to maintain tumorigenesis and immunotherapy resistance	46
The mitochondrial unfolded protein response regulates hippocampal neural stem cell aging	46
SUCNR1 signaling in adipocytes controls energy metabolism by modulating circadian clock and leptin expression	46
Physiologic disruption and metabolic reprogramming in infection and sepsis	46
Extracellular HSP90 warms up integrins for an irisin workout	45
Embracing the unknown: Proteomic insights into the human microbiome	45
Colonic macrophages eat and feed	45
Hyperglycemia in acute COVID-19 is characterized by insulin resistance and adipose tissue infectivity by SARS-CoV-2	45
Nicotinic acid riboside maintains NAD+ homeostasis and ameliorates aging-associated NAD+ decline	45
The effects of obesity and metabolic abnormalities on severe COVID-19-related outcomes after vaccination: A population-based study	45
Impact of biological sex and sex hormones on molecular signatures of skeletal muscle at rest and in response to distinct exercise training modes	44
Innate immune response orchestrates phosphoribosyl pyrophosphate synthetases to support DNA repair	44
Meta-hallmarks of aging and cancer	44
PRMT1 orchestrates with SAMTOR to govern mTORC1 methionine sensing via Arg-methylation of NPRL2	44
Multi-omic human pancreatic islet endoplasmic reticulum and cytokine stress response mapping provides type 2 diabetes genetic insights	44
SREBP1c-PARP1 axis tunes anti-senescence activity of adipocytes and ameliorates metabolic imbalance in obesity	44
Hepatic lipid remodeling in cold exposure uncovers direct regulation of bis(monoacylglycero)phosphate lipids by phospholipase A2 group XV	44
The hormesis principle of neuroplasticity and neuroprotection	43
Molecular and metabolic heterogeneity of astrocytes and microglia	43
Cancer-cell-derived fumarate suppresses the anti-tumor capacity of CD8+ T cells in the tumor microenvironment	43
High dietary fructose promotes hepatocellular carcinoma progression by enhancing O-GlcNAcylation via microbiota-derived acetate	43
Positive feedback regulation of microglial glucose metabolism by histone H4 lysine 12 lactylation in Alzheimer’s disease	43
Astrocytic LRP1 enables mitochondria transfer to neurons and mitigates brain ischemic stroke by suppressing ARF1 lactylation	42
Dysfunctional circadian clock accelerates cancer metastasis by intestinal microbiota triggering accumulation of myeloid-derived suppressor cells	42
Acetylated cellulose suppresses body mass gain through gut commensals consuming host-accessible carbohydrates	42