Cell Metabolism

Article	Citations
The secret life of lactate: A novel cell-cycle regulatory mechanism	1002
Cap CASP, not SCAP, to fight steatohepatitis	668
Sex- and timing-specific effects of fasting and caloric restriction	605
Development of a functional beige fat cell line uncovers independent subclasses of cells expressing UCP1 and the futile creatine cycle	571
Adipocyte-derived extracellular vesicles are key regulators of central leptin sensitivity and energy homeostasis	567
Dopaminylation of endothelial TPI1 suppresses ferroptotic angiocrine signals to promote lung regeneration over fibrosis	519
Lysine acetyltransferase 6A maintains CD4+ T cell response via epigenetic reprogramming of glucose metabolism in autoimmunity	448
Unveiling adipose populations linked to metabolic health in obesity	430
Metabolic switch regulates lineage plasticity and induces synthetic lethality in triple-negative breast cancer	408
DMHPpp1r17 neurons regulate aging and lifespan in mice through hypothalamic-adipose inter-tissue communication	397
The Achilles heel of TNBCs: Ferroptosis heterogeneity	362
Time-restricted eating and exercise training improve HbA1c and body composition in women with overweight/obesity: A randomized controlled trial	293
“Sweet death”: Fructose as a metabolic toxin that targets the gut-liver axis	283
The Type 2 Diabetes Knowledge Portal: An open access genetic resource dedicated to type 2 diabetes and related traits	278
Association of genetic risk, lifestyle, and their interaction with obesity and obesity-related morbidities	260
Lactate homeostasis is maintained through regulation of glycolysis and lipolysis	258
Sex and genetic background define the metabolic, physiologic, and molecular response to protein restriction	246
Glucagon promotes increased hepatic mitochondrial oxidation and pyruvate carboxylase flux in humans with fatty liver disease	236
mTOR takes charge: Relaying uncharged tRNA levels by mTOR ubiquitination	232
Sugar addiction: An Achilles’ heel of auto-immune diseases?	227
Supercharging cancer-fighting T cells with lithium carbonate	226
The integrated stress response fine-tunes stem cell fate decisions upon serine deprivation and tissue injury	219
A hierarchical hepatic de novo lipogenesis substrate supply network utilizing pyruvate, acetate, and ketones	218
Spatial regulation of glucose and lipid metabolism by hepatic insulin signaling	213
Fructose-1,6-bisphosphatase is a nonenzymatic safety valve that curtails AKT activation to prevent insulin hyperresponsiveness	206

Sphingolipid metabolism controls mammalian heart regeneration	201
Metabolic regulation of the glioblastoma stem cell epitranscriptome by malate dehydrogenase 2	199
Metabolic adaptation supports enhanced macrophage efferocytosis in limited-oxygen environments	199
PHGDH-mediated endothelial metabolism drives glioblastoma resistance to chimeric antigen receptor T cell immunotherapy	182
Kir2.1 channel: Macrophage plasticity in tumor microenvironment	177
PHLDA2-mediated phosphatidic acid peroxidation triggers a distinct ferroptotic response during tumor suppression	177
The cephalic phase of insulin release is modulated by IL-1β	173
A novel protein CYTB-187AA encoded by the mitochondrial gene CYTB modulates mammalian early development	173
Dynamic scRNA-seq of live human pancreatic slices reveals functional endocrine cell neogenesis through an intermediate ducto-acinar stage	170
Isolation of extracellular fluids reveals novel secreted bioactive proteins from muscle and fat tissues	169
Mitochondrial membrane lipids in the regulation of bioenergetic flux	168
STING orchestrates the crosstalk between polyunsaturated fatty acid metabolism and inflammatory responses	167
A microbial metabolite inhibits the HIF-2α-ceramide pathway to mediate the beneficial effects of time-restricted feeding on MASH	166
Nutrient allocation fuels T cell-mediated immunity	166
Defend or reproduce? Muscle-derived glutamate determines an immune-reproductive energetic tradeoff	163
Focus on diet and exercise	161
Paraventricular glia drive circuit function to control metabolism	158
Targeting PDAC metabolism: Environment determines what has GOT2 give	149
Di-methylation of CD147-K234 Promotes the Progression of NSCLC by Enhancing Lactate Export	149
Understanding the metabolism of infants using whole-body metabolic models	145
Testing the carbohydrate-insulin model: Short-term metabolic responses to consumption of meals with varying glycemic index in healthy adults	143
Early prediction of incident liver disease using conventional risk factors and gut-microbiome-augmented gradient boosting	142
HNF1A and A1CF coordinate a beta cell transcription-splicing axis that is disrupted in type 2 diabetes	139
Molecular mechanisms of snoRNA-IL-15 crosstalk in adipocyte lipolysis and NK cell rejuvenation	139
MGAT2 inhibitor decreases liver fibrosis and inflammation in murine NASH models and reduces body weight in human adults with obesity	138
PDIA3 defines a novel subset of adipose macrophages to exacerbate the development of obesity and metabolic disorders	137
Amino acid is a major carbon source for hepatic lipogenesis	136
Localized GLP1 receptor pre-internalization directs pancreatic alpha cell to beta cell communication	133
Bone marrow immune cells respond to fluctuating nutritional stress to constrain weight regain	133
Glutamate metabolism directs energetic trade-offs to shape host-pathogen susceptibility in Drosophila	132
Organ-specific fuel rewiring in acute and chronic hypoxia redistributes glucose and fatty acid metabolism	131
Exosomal miR-302b rejuvenates aging mice by reversing the proliferative arrest of senescent cells	131
Evaluating human genetic support for hypothesized metabolic disease genes	130
Effect of alternate day fasting combined with aerobic exercise on non-alcoholic fatty liver disease: A randomized controlled trial	130
Maternal circadian rhythms during pregnancy dictate metabolic plasticity in offspring	130
Excess pancreatic elastase alters acinar-β cell communication by impairing the mechano-signaling and the PAR2 pathways	126
The crosstalk between bone remodeling and energy metabolism: A translational perspective	126
The past, present, and future physiology and pharmacology of glucagon	125
EHBP1 suppresses liver fibrosis in metabolic dysfunction-associated steatohepatitis	123
Digital twins for in vivo metabolic flux estimations in patients with brain cancer	121
Aerobic glycolysis promotes tumor immune evasion by hexokinase2-mediated phosphorylation of IκBα	121
Famsin and fasting adaptation: A glucagon connection	119
Psychological stress-induced microbial metabolite indole-3-acetate disrupts intestinal cell lineage commitment	118
Beggars banquet: Metabolism in the tumor immune microenvironment and cancer therapy	117
Deciphering the metabolic heterogeneity of hematopoietic stem cells with single-cell resolution	113
Obesity-associated microglial inflammatory activation paradoxically improves glucose tolerance	111
Cardiometabolic health improvements upon dietary intervention are driven by tissue-specific insulin resistance phenotype: A precision nutrition trial	109
Extracellular vesicles in fatty liver promote a metastatic tumor microenvironment	109
Lactobacillus plantarum-derived indole-3-lactic acid ameliorates colorectal tumorigenesis via epigenetic regulation of CD8+ T cell immunity	109
Targeting gut microbial nitrogen recycling and cellular uptake of ammonium to improve bortezomib resistance in multiple myeloma	108

Defects in a liver-bone axis contribute to hepatic osteodystrophy disease progression	107
Dietary-timing-induced gut microbiota diurnal oscillations modulate inflammatory rhythms in rheumatoid arthritis	104
Microbiome-derived metabolites counteract tumor-induced immunosuppression and boost immune checkpoint blockade	103
Response to Paik et al. on the disease burden of NAFLD	103
Biting into a union of oncology and metabolism through leukemic stem cells	103
“Shunt-ing” down obesity with novel endogenous metabolites	101
Liver microbes controlling immunity: Facts and pitfalls	99
Anti-seizure effects of norepinephrine-induced free fatty acid release	99
A key role of PIEZO2 mechanosensitive ion channel in adipose sensory innervation	97
Glycometabolic reprogramming-induced XRCC1 lactylation confers therapeutic resistance in ALDH1A3-overexpressing glioblastoma	97
Selenium mediates exercise-induced adult neurogenesis and reverses learning deficits induced by hippocampal injury and aging	96
Microglial lipid droplet accumulation in tauopathy brain is regulated by neuronal AMPK	95
Understanding the variation in exercise responses to guide personalized physical activity prescriptions	95
Effects on weight loss and glycemic control with SAR441255, a potent unimolecular peptide GLP-1/GIP/GCG receptor triagonist	94
Tumor-associated macrophages are shaped by intratumoral high potassium via Kir2.1	93
Single-cell transcriptomic and spatial landscapes of the developing human pancreas	92
Acetate enables metabolic fitness and cognitive performance during sleep disruption	92
Linoleic acid potentiates CD8+ T cell metabolic fitness and antitumor immunity	91
Emerging therapies in cancer metabolism	91
Cancer cells co-opt nociceptive nerves to thrive in nutrient-poor environments and upon nutrient-starvation therapies	91
Lighting up arginine metabolism reveals its functional diversity in physiology and pathology	90
Human genetics identify convergent signals in mitochondrial LACTB-mediated lipid metabolism in cardiovascular-kidney-metabolic syndrome	90
Defying “IL-11ness” by inhibiting inflammation: Strategy for health and longevity	89
Does sweet turn sour? How aspartame aggravates atherosclerosis in a preclinical model	89
Missed signals: How PET imaging may fail to capture the addictive potential of ultra-processed foods	88
SLC25A48 controls mitochondrial choline import and metabolism	87
FGF21 suppresses alcohol consumption through an amygdalo-striatal circuit	87
Glycerate from intestinal fructose metabolism induces islet cell damage and glucose intolerance	87
Molecular aspects of fructose metabolism and metabolic disease	86
A nutrigeroscience approach: Dietary macronutrients and cellular senescence	86
Integrative genetic analysis identifies FLVCR1 as a plasma-membrane choline transporter in mammals	86
OMA1-mediated integrated stress response protects against ferroptosis in mitochondrial cardiomyopathy	85
Multi-organ transcriptome atlas of a mouse model of relative energy deficiency in sport	84
Vps37a regulates hepatic glucose production by controlling glucagon receptor localization to endosomes	83
Adipocyte-derived glutathione promotes obesity-related breast cancer by regulating the SCARB2-ARF1-mTORC1 complex	83
Urea cycle activation triggered by host-microbiota maladaptation driving colorectal tumorigenesis	82
The tRNA-GCN2-FBXO22-axis-mediated mTOR ubiquitination senses amino acid insufficiency	82
GDF15 enhances body weight and adiposity reduction in obese mice by leveraging the leptin pathway	82
Fueling metabolic disruption via FMD to boost chemotherapy in TNBC	81
Dietary timing enhances exercise by modulating fat-muscle crosstalk via adipocyte AMPKα2 signaling	81
Intracellular infection and immune system cues rewire adipocytes to acquire immune function	81
Hepatic malonyl-CoA synthesis restrains gluconeogenesis by suppressing fat oxidation, pyruvate carboxylation, and amino acid availability	80
The intersection of frailty and metabolism	80
Hierarchical tricarboxylic acid cycle regulation by hepatocyte arginase 2 links the urea cycle to oxidative metabolism	79
Timed feeding aligns the adipocyte clock to optimize thermogenesis when eating a high-fat diet	79
Intermittent fasting boosts sexual behavior by limiting the central availability of tryptophan and serotonin	79
Diabetic retinopathy is a ceramidopathy reversible by anti-ceramide immunotherapy	79
Preventing metabolic disease: Part I	79
The NARly side of whole-body NAD homeostasis	79
Branching out beyond canonical brown adipocyte function	79
Vive la resistant starch: A potential treatment for metabolic dysfunction-associated steatohepatitis	79
Not so neutral lipids: Metabolic regulation of the pre-metastatic niche	78
FGF21 reverses MASH through coordinated actions on the CNS and liver	77
Targeting p21Cip1 highly expressing cells in adipose tissue alleviates insulin resistance in obesity	77
Liver mitochondrial cristae organizing protein MIC19 promotes energy expenditure and pedestrian locomotion by altering nucleotide metabolism	77
Unlocking the power of postbiotics: A revolutionary approach to nutrition for humans and animals	77
Pyruvate kinase M2 activation reprograms mitochondria in CD8 T cells, enhancing effector functions and efficacy of anti-PD1 therapy	76
Age-related ciliopathy: Obesogenic shortening of melanocortin-4 receptor-bearing neuronal primary cilia	76
NRF2 activation induces NADH-reductive stress, providing a metabolic vulnerability in lung cancer	75
Realigned transsulfuration drives BRAF-V600E-targeted therapy resistance in melanoma	74
Cytosolic pH is a direct nexus in linking environmental cues with insulin processing and secretion in pancreatic β cells	74
Extracellular vesicles mediate the communication of adipose tissue with brain and promote cognitive impairment associated with insulin resistance	73
Microbiota-gut-brain axis drives overeating disorders	73
Metabolic programs tailor T cell immunity in viral infection, cancer, and aging	72
Downregulation of the kidney glucagon receptor, essential for renal function and systemic homeostasis, contributes to chronic kidney disease	72
Integrating multiplex immunofluorescent and mass spectrometry imaging to map myeloid heterogeneity in its metabolic and cellular context	72
LY3437943, a novel triple glucagon, GIP, and GLP-1 receptor agonist for glycemic control and weight loss: From discovery to clinical proof of concept	72
Hepatocyte CHRNA4 mediates the MASH-promotive effects of immune cell-produced acetylcholine and smoking exposure in mice and humans	71
NAD depletion in skeletal muscle does not compromise muscle function or accelerate aging	70
Two independent respiratory chains adapt OXPHOS performance to glycolytic switch	70
Paternal exercise confers endurance capacity to offspring through sperm microRNAs	70
Scale-spanning crosstalk between metabolism and information processing	70
NAD depletion in skeletal muscle does not compromise muscle function or accelerate aging	69
Diabesity? No worries, FKBP11 to the rescue	69
Extracellular vesicles from obese visceral adipose promote pancreatic cancer development and resistance to immune checkpoint blockade therapy	69
Body-wide multi-omic counteraction of aging with GLP-1R agonism	69
Fight, flight, and freeze!	68
A pattern emerges in chromatin aging: AP-1 steals the show	67
Krebs takes a turn at cell differentiation	67
Outrunning obesity with Lac-Phe?	66

Neutrophils resist ferroptosis and promote breast cancer metastasis through aconitate decarboxylase 1	66
Ergothioneine improves healthspan of aged animals by enhancing cGPDH activity through CSE-dependent persulfidation	66
A mechanosensitive lipolytic factor in the bone marrow promotes osteogenesis and lymphopoiesis	66
Genetics-nutrition interactions control diurnal enhancer-promoter dynamics and liver lipid metabolism	66
Gut microbial alterations in arginine metabolism determine bone mechanical adaptation	66
GLP-1/GIP/glucagon receptor triagonism gets its try in humans	65
Thymidine kinase 1 drives hepatocellular carcinoma in enzyme-dependent and -independent manners	65
The NADPARK study: A randomized phase I trial of nicotinamide riboside supplementation in Parkinson’s disease	65
T-bet B or not T-bet B, is that the question in obesity-related metabolic disease?	65
Bempedoic acid suppresses diet-induced hepatic steatosis independently of ATP-citrate lyase	65
Inflammation and cholesterol at the crossroads of vascular risk	64
TOX4, an insulin receptor-independent regulator of hepatic glucose production, is activated in diabetic liver	64
A human omentum-specific mesothelial-like stromal population inhibits adipogenesis through IGFBP2 secretion	64
m6A mRNA methylation in brown fat regulates systemic insulin sensitivity via an inter-organ prostaglandin signaling axis independent of UCP1	64
Itaconate transporter SLC13A3 confers immunotherapy resistance via alkylation-mediated stabilization of PD-L1	64
Synergistic role of gut-microbial L-ornithine in enhancing ustekinumab efficacy for Crohn’s disease	64
The neurocircuitry of fasting-induced glucocorticoid release	63
Warburg-like metabolic transformation underlies neuronal degeneration in sporadic Alzheimer’s disease	63
Comparative transcriptomics reveals circadian and pluripotency networks as two pillars of longevity regulation	63
Heterogenous impairment of α cell function in type 2 diabetes is linked to cell maturation state	62
Immunoediting instructs tumor metabolic reprogramming to support immune evasion	62
Leptin enhances the intracellular thyroid hormone activation in skeletal muscle to boost energy balance	62
Region-specific transcriptomic responses to obesity and diabetes in macaque hypothalamus	62
Carbon source availability drives nutrient utilization in CD8+ T cells	62
Identification of a molecular resistor that controls UCP1-independent Ca2+ cycling thermogenesis in adipose tissue	62
Intermittent clearance of p21-highly-expressing cells extends lifespan and confers sustained benefits to health and physical function	62
Mitochondrial isocitrate dehydrogenase impedes CAR T cell function by restraining antioxidant metabolism and histone acetylation	61
TM7SF3 controls TEAD1 splicing to prevent MASH-induced liver fibrosis	61
Mitochondrial metabolism coordinates stage-specific repair processes in macrophages during wound healing	61
Targeting metabolic circuitry to supercharge CD8+ T cell antitumor responses	60
Hepatic FXR-FGF4 is required for bile acid homeostasis via an FGFR4-LRH-1 signal node under cholestatic stress	60
Short-term cold exposure induces persistent epigenomic memory in brown fat	60
Ketogenic diet promotes tumor ferroptosis but induces relative corticosterone deficiency that accelerates cachexia	60
The mitochondrial multi-omic response to exercise training across rat tissues	60
A microbial metabolite inhibits the HIF-2α-ceramide pathway to mediate the beneficial effects of time-restricted feeding on MASH	59
Toward the next 20 years of Cell Metabolism	59
Reassessment of antibody-based detection of the murine T cell GLP-1 receptor	59
Making a sPLAsh: The expanding repertoire of EV signaling	58
GDF15 analogs as obesity therapeutics	58
Peter J. Roach (1948–2022)	58
Circulating glycerate predicts resilience to fructose-induced hepatic steatosis	58
Non-invasive lipid panel of MASLD fibrosis transition underscores the role of lipoprotein sulfatides in hepatic immunomodulation	58
Acetate controls endothelial-to-mesenchymal transition	57
Stress-induced β cell early senescence confers protection against type 1 diabetes	57
Ergothioneine controls mitochondrial function and exercise performance via direct activation of MPST	57