Cell Metabolism

Article	Citations
The secret life of lactate: A novel cell-cycle regulatory mechanism	844
Cap CASP, not SCAP, to fight steatohepatitis	526
The Achilles heel of TNBCs: Ferroptosis heterogeneity	504
The search for thermoregulatory neurons is heating up	450
Lysine acetyltransferase 6A maintains CD4+ T cell response via epigenetic reprogramming of glucose metabolism in autoimmunity	446
Sex- and timing-specific effects of fasting and caloric restriction	393
Unveiling adipose populations linked to metabolic health in obesity	392
Association of genetic risk, lifestyle, and their interaction with obesity and obesity-related morbidities	392
Development of a functional beige fat cell line uncovers independent subclasses of cells expressing UCP1 and the futile creatine cycle	363
The Type 2 Diabetes Knowledge Portal: An open access genetic resource dedicated to type 2 diabetes and related traits	343
“Sweet death”: Fructose as a metabolic toxin that targets the gut-liver axis	342
Dopaminylation of endothelial TPI1 suppresses ferroptotic angiocrine signals to promote lung regeneration over fibrosis	329
Time-restricted eating and exercise training improve HbA1c and body composition in women with overweight/obesity: A randomized controlled trial	323
DMHPpp1r17 neurons regulate aging and lifespan in mice through hypothalamic-adipose inter-tissue communication	318
Sex and genetic background define the metabolic, physiologic, and molecular response to protein restriction	306
Lactate homeostasis is maintained through regulation of glycolysis and lipolysis	295
Glucagon promotes increased hepatic mitochondrial oxidation and pyruvate carboxylase flux in humans with fatty liver disease	294
Metabolic switch regulates lineage plasticity and induces synthetic lethality in triple-negative breast cancer	294
Adipocyte iron levels impinge on a fat-gut crosstalk to regulate intestinal lipid absorption and mediate protection from obesity	278
Spatial regulation of glucose and lipid metabolism by hepatic insulin signaling	241
Microvessels enhance vascularization and function of transplanted insulin-producing cells	234
Supercharging cancer-fighting T cells with lithium carbonate	229
Sugar addiction: An Achilles’ heel of auto-immune diseases?	218
Kir2.1 channel: Macrophage plasticity in tumor microenvironment	212
Metabolic regulation of the glioblastoma stem cell epitranscriptome by malate dehydrogenase 2	207

Dynamic scRNA-seq of live human pancreatic slices reveals functional endocrine cell neogenesis through an intermediate ducto-acinar stage	206
A hierarchical hepatic de novo lipogenesis substrate supply network utilizing pyruvate, acetate, and ketones	202
The integrated stress response fine-tunes stem cell fate decisions upon serine deprivation and tissue injury	201
PHLDA2-mediated phosphatidic acid peroxidation triggers a distinct ferroptotic response during tumor suppression	198
Mitochondrial cristae-remodeling protein OPA1 in POMC neurons couples Ca2+ homeostasis with adipose tissue lipolysis	194
The cephalic phase of insulin release is modulated by IL-1β	194
Isolation of extracellular fluids reveals novel secreted bioactive proteins from muscle and fat tissues	189
PHGDH-mediated endothelial metabolism drives glioblastoma resistance to chimeric antigen receptor T cell immunotherapy	175
Metabolic adaptation supports enhanced macrophage efferocytosis in limited-oxygen environments	172
Sphingolipid metabolism controls mammalian heart regeneration	172
Adhesion-mediated mechanosignaling forces mitohormesis	169
mTOR takes charge: Relaying uncharged tRNA levels by mTOR ubiquitination	167
A novel protein CYTB-187AA encoded by the mitochondrial gene CYTB modulates mammalian early development	163
Fructose-1,6-bisphosphatase is a nonenzymatic safety valve that curtails AKT activation to prevent insulin hyperresponsiveness	160
FXR activation protects against NAFLD via bile-acid-dependent reductions in lipid absorption	158
STING orchestrates the crosstalk between polyunsaturated fatty acid metabolism and inflammatory responses	155
A microbial metabolite inhibits the HIF-2α-ceramide pathway to mediate the beneficial effects of time-restricted feeding on MASH	154
Mitochondrial membrane lipids in the regulation of bioenergetic flux	154
Excess pancreatic elastase alters acinar-β cell communication by impairing the mechano-signaling and the PAR2 pathways	150
EHBP1 suppresses liver fibrosis in metabolic dysfunction-associated steatohepatitis	147
Testing the carbohydrate-insulin model: Short-term metabolic responses to consumption of meals with varying glycemic index in healthy adults	147
Di-methylation of CD147-K234 Promotes the Progression of NSCLC by Enhancing Lactate Export	146
Understanding the metabolism of infants using whole-body metabolic models	145
Defend or reproduce? Muscle-derived glutamate determines an immune-reproductive energetic tradeoff	144
Paraventricular glia drive circuit function to control metabolism	140
Focus on diet and exercise	139
Targeting PDAC metabolism: Environment determines what has GOT2 give	139
The crosstalk between bone remodeling and energy metabolism: A translational perspective	139
MGAT2 inhibitor decreases liver fibrosis and inflammation in murine NASH models and reduces body weight in human adults with obesity	136
Maternal circadian rhythms during pregnancy dictate metabolic plasticity in offspring	132
Organ-specific fuel rewiring in acute and chronic hypoxia redistributes glucose and fatty acid metabolism	130
Glutamate metabolism directs energetic trade-offs to shape host-pathogen susceptibility in Drosophila	129
The past, present, and future physiology and pharmacology of glucagon	128
Early prediction of incident liver disease using conventional risk factors and gut-microbiome-augmented gradient boosting	126
Evaluating human genetic support for hypothesized metabolic disease genes	125
PDIA3 defines a novel subset of adipose macrophages to exacerbate the development of obesity and metabolic disorders	124
Effect of alternate day fasting combined with aerobic exercise on non-alcoholic fatty liver disease: A randomized controlled trial	123
Molecular mechanisms of snoRNA-IL-15 crosstalk in adipocyte lipolysis and NK cell rejuvenation	122
Exosomes as mediators of intercellular crosstalk in metabolism	119
Amino acid is a major carbon source for hepatic lipogenesis	119
Exosomal miR-302b rejuvenates aging mice by reversing the proliferative arrest of senescent cells	118
Aerobic glycolysis promotes tumor immune evasion by hexokinase2-mediated phosphorylation of IκBα	118
Response to Paik et al. on the disease burden of NAFLD	117
Bone marrow immune cells respond to fluctuating nutritional stress to constrain weight regain	117
Biting into a union of oncology and metabolism through leukemic stem cells	116
Famsin and fasting adaptation: A glucagon connection	116
Liver microbes controlling immunity: Facts and pitfalls	114
“Shunt-ing” down obesity with novel endogenous metabolites	114
Dietary-timing-induced gut microbiota diurnal oscillations modulate inflammatory rhythms in rheumatoid arthritis	114
Anti-seizure effects of norepinephrine-induced free fatty acid release	113

A key role of PIEZO2 mechanosensitive ion channel in adipose sensory innervation	113
Microglial lipid droplet accumulation in tauopathy brain is regulated by neuronal AMPK	110
Microbiome-derived metabolites counteract tumor-induced immunosuppression and boost immune checkpoint blockade	109
Obesity-associated microglial inflammatory activation paradoxically improves glucose tolerance	104
Effects on weight loss and glycemic control with SAR441255, a potent unimolecular peptide GLP-1/GIP/GCG receptor triagonist	102
Cancer cells co-opt nociceptive nerves to thrive in nutrient-poor environments and upon nutrient-starvation therapies	102
Single-cell transcriptomic and spatial landscapes of the developing human pancreas	99
Defects in a liver-bone axis contribute to hepatic osteodystrophy disease progression	99
Psychological stress-induced microbial metabolite indole-3-acetate disrupts intestinal cell lineage commitment	98
Linoleic acid potentiates CD8+ T cell metabolic fitness and antitumor immunity	98
Selenium mediates exercise-induced adult neurogenesis and reverses learning deficits induced by hippocampal injury and aging	98
Cardiometabolic health improvements upon dietary intervention are driven by tissue-specific insulin resistance phenotype: A precision nutrition trial	98
Cardiovascular disease in diabetes, beyond glucose	97
Tumor-associated macrophages are shaped by intratumoral high potassium via Kir2.1	96
Emerging therapies in cancer metabolism	93
Glycometabolic reprogramming-induced XRCC1 lactylation confers therapeutic resistance in ALDH1A3-overexpressing glioblastoma	93
Understanding the variation in exercise responses to guide personalized physical activity prescriptions	93
Lactobacillus plantarum-derived indole-3-lactic acid ameliorates colorectal tumorigenesis via epigenetic regulation of CD8+ T cell immunity	92
Extracellular vesicles in fatty liver promote a metastatic tumor microenvironment	92
Targeting gut microbial nitrogen recycling and cellular uptake of ammonium to improve bortezomib resistance in multiple myeloma	91
Acetate enables metabolic fitness and cognitive performance during sleep disruption	91
Deciphering the metabolic heterogeneity of hematopoietic stem cells with single-cell resolution	88
Defying “IL-11ness” by inhibiting inflammation: Strategy for health and longevity	88
Beggars banquet: Metabolism in the tumor immune microenvironment and cancer therapy	88
Fueling metabolic disruption via FMD to boost chemotherapy in TNBC	87
The Gro3p factor: Restoring NAD+/NADH homeostasis to ameliorate mitochondrial disease	86
Human genetics identify convergent signals in mitochondrial LACTB-mediated lipid metabolism in cardiovascular-kidney-metabolic syndrome	85
SLC25A48 controls mitochondrial choline import and metabolism	85
Diabetic retinopathy is a ceramidopathy reversible by anti-ceramide immunotherapy	85
Does sweet turn sour? How aspartame aggravates atherosclerosis in a preclinical model	84
The tRNA-GCN2-FBXO22-axis-mediated mTOR ubiquitination senses amino acid insufficiency	82
Integrative genetic analysis identifies FLVCR1 as a plasma-membrane choline transporter in mammals	82
Intracellular infection and immune system cues rewire adipocytes to acquire immune function	81
Vps37a regulates hepatic glucose production by controlling glucagon receptor localization to endosomes	80
Top-down control of conditioned overconsumption is mediated by insular cortex Nos1 neurons	78
Molecular aspects of fructose metabolism and metabolic disease	78
GDF15 enhances body weight and adiposity reduction in obese mice by leveraging the leptin pathway	78
Adipocyte-derived glutathione promotes obesity-related breast cancer by regulating the SCARB2-ARF1-mTORC1 complex	78
Glycerate from intestinal fructose metabolism induces islet cell damage and glucose intolerance	78
Dietary timing enhances exercise by modulating fat-muscle crosstalk via adipocyte AMPKα2 signaling	76
FGF21 suppresses alcohol consumption through an amygdalo-striatal circuit	76
Multi-organ transcriptome atlas of a mouse model of relative energy deficiency in sport	76
Hierarchical tricarboxylic acid cycle regulation by hepatocyte arginase 2 links the urea cycle to oxidative metabolism	76
Combined glucocorticoid resistance and hyperlactatemia contributes to lethal shock in sepsis	75
A nutrigeroscience approach: Dietary macronutrients and cellular senescence	74
Urea cycle activation triggered by host-microbiota maladaptation driving colorectal tumorigenesis	74
Hepatic malonyl-CoA synthesis restrains gluconeogenesis by suppressing fat oxidation, pyruvate carboxylation, and amino acid availability	73
The intersection of frailty and metabolism	73
OMA1-mediated integrated stress response protects against ferroptosis in mitochondrial cardiomyopathy	73
Preventing metabolic disease: Part I	72
T cells critically depend on pyruvate oxidation	71
Intermittent fasting boosts sexual behavior by limiting the central availability of tryptophan and serotonin	71
Pyruvate kinase M2 activation reprograms mitochondria in CD8 T cells, enhancing effector functions and efficacy of anti-PD1 therapy	71
Timed feeding aligns the adipocyte clock to optimize thermogenesis when eating a high-fat diet	71
Downregulation of the kidney glucagon receptor, essential for renal function and systemic homeostasis, contributes to chronic kidney disease	71
The therapeutic promises of NAD+ boosters	70
Hepatocyte CHRNA4 mediates the MASH-promotive effects of immune cell-produced acetylcholine and smoking exposure in mice and humans	69
Not so neutral lipids: Metabolic regulation of the pre-metastatic niche	69
Vive la resistant starch: A potential treatment for metabolic dysfunction-associated steatohepatitis	69
Integrating multiplex immunofluorescent and mass spectrometry imaging to map myeloid heterogeneity in its metabolic and cellular context	69
Branching out beyond canonical brown adipocyte function	69
Two independent respiratory chains adapt OXPHOS performance to glycolytic switch	68
Deoxyhypusine synthase promotes a pro-inflammatory macrophage phenotype	68
Liver mitochondrial cristae organizing protein MIC19 promotes energy expenditure and pedestrian locomotion by altering nucleotide metabolism	68
Cytosolic pH is a direct nexus in linking environmental cues with insulin processing and secretion in pancreatic β cells	67
FGF21 reverses MASH through coordinated actions on the CNS and liver	67
The thermogenic activity of adjacent adipocytes fuels the progression of ccRCC and compromises anti-tumor therapeutic efficacy	66
LY3437943, a novel triple glucagon, GIP, and GLP-1 receptor agonist for glycemic control and weight loss: From discovery to clinical proof of concept	66
Metabolic programs tailor T cell immunity in viral infection, cancer, and aging	66
Extracellular vesicles mediate the communication of adipose tissue with brain and promote cognitive impairment associated with insulin resistance	65
Isthmin-1 is an adipokine that promotes glucose uptake and improves glucose tolerance and hepatic steatosis	65
SARS-CoV-2 infects human pancreatic β cells and elicits β cell impairment	65
Age-related ciliopathy: Obesogenic shortening of melanocortin-4 receptor-bearing neuronal primary cilia	65
Microbiota-gut-brain axis drives overeating disorders	65
Realigned transsulfuration drives BRAF-V600E-targeted therapy resistance in melanoma	65
NRF2 activation induces NADH-reductive stress, providing a metabolic vulnerability in lung cancer	64
Unlocking the power of postbiotics: A revolutionary approach to nutrition for humans and animals	64
NAD depletion in skeletal muscle does not compromise muscle function or accelerate aging	64
Fight, flight, and freeze!	64
Targeting p21Cip1 highly expressing cells in adipose tissue alleviates insulin resistance in obesity	64

Bempedoic acid suppresses diet-induced hepatic steatosis independently of ATP-citrate lyase	63
A dietary source of antibiotic tolerance	63
A pattern emerges in chromatin aging: AP-1 steals the show	63
Diabesity? No worries, FKBP11 to the rescue	63
Thymidine kinase 1 drives hepatocellular carcinoma in enzyme-dependent and -independent manners	62
Outrunning obesity with Lac-Phe?	62
Krebs takes a turn at cell differentiation	62
Ergothioneine improves healthspan of aged animals by enhancing cGPDH activity through CSE-dependent persulfidation	61
Gut microbial alterations in arginine metabolism determine bone mechanical adaptation	61
The NADPARK study: A randomized phase I trial of nicotinamide riboside supplementation in Parkinson’s disease	59
Neutrophils resist ferroptosis and promote breast cancer metastasis through aconitate decarboxylase 1	59
A mechanosensitive lipolytic factor in the bone marrow promotes osteogenesis and lymphopoiesis	58
Tumor-derived exosomes drive immunosuppressive macrophages in a pre-metastatic niche through glycolytic dominant metabolic reprogramming	58
Itaconate transporter SLC13A3 confers immunotherapy resistance via alkylation-mediated stabilization of PD-L1	58
GLP-1/GIP/glucagon receptor triagonism gets its try in humans	58
Comparative transcriptomics reveals circadian and pluripotency networks as two pillars of longevity regulation	57
The neurocircuitry of fasting-induced glucocorticoid release	57
Identification of a molecular resistor that controls UCP1-independent Ca2+ cycling thermogenesis in adipose tissue	57
Synergistic role of gut-microbial L-ornithine in enhancing ustekinumab efficacy for Crohn’s disease	57
Heterogenous impairment of α cell function in type 2 diabetes is linked to cell maturation state	56
Inflammation and cholesterol at the crossroads of vascular risk	56
Targeting metabolic circuitry to supercharge CD8+ T cell antitumor responses	56
Leptin enhances the intracellular thyroid hormone activation in skeletal muscle to boost energy balance	55
T-bet B or not T-bet B, is that the question in obesity-related metabolic disease?	55
TOX4, an insulin receptor-independent regulator of hepatic glucose production, is activated in diabetic liver	55
TM7SF3 controls TEAD1 splicing to prevent MASH-induced liver fibrosis	54
Immunoediting instructs tumor metabolic reprogramming to support immune evasion	54
A human omentum-specific mesothelial-like stromal population inhibits adipogenesis through IGFBP2 secretion	54
Intermittent clearance of p21-highly-expressing cells extends lifespan and confers sustained benefits to health and physical function	54
Short-term cold exposure induces persistent epigenomic memory in brown fat	53
Region-specific transcriptomic responses to obesity and diabetes in macaque hypothalamus	53
The mitochondrial multi-omic response to exercise training across rat tissues	53
Carbon source availability drives nutrient utilization in CD8+ T cells	53
First we eat, then we do everything else: The dynamic metabolic regulation of efferocytosis	53
Mitochondrial isocitrate dehydrogenase impedes CAR T cell function by restraining antioxidant metabolism and histone acetylation	53
Ketogenic diet promotes tumor ferroptosis but induces relative corticosterone deficiency that accelerates cachexia	52
Mitochondrial metabolism coordinates stage-specific repair processes in macrophages during wound healing	52
m6A mRNA methylation in brown fat regulates systemic insulin sensitivity via an inter-organ prostaglandin signaling axis independent of UCP1	52
Peter J. Roach (1948–2022)	51
GDF15 analogs as obesity therapeutics	51
Warburg-like metabolic transformation underlies neuronal degeneration in sporadic Alzheimer’s disease	51
Elevated Hypothalamic TCPTP in Obesity Contributes to Cellular Leptin Resistance	51
Hepatic FXR-FGF4 is required for bile acid homeostasis via an FGFR4-LRH-1 signal node under cholestatic stress	51
Making a sPLAsh: The expanding repertoire of EV signaling	50
A microbial metabolite inhibits the HIF-2α-ceramide pathway to mediate the beneficial effects of time-restricted feeding on MASH	50
Exercise induces tissue-specific adaptations to enhance cardiometabolic health	49
Non-invasive lipid panel of MASLD fibrosis transition underscores the role of lipoprotein sulfatides in hepatic immunomodulation	49
Circulating glycerate predicts resilience to fructose-induced hepatic steatosis	49
Transcriptomic, epigenomic, and spatial metabolomic cell profiling redefines regional human kidney anatomy	49
Stress-induced β cell early senescence confers protection against type 1 diabetes	49
Ergothioneine controls mitochondrial function and exercise performance via direct activation of MPST	49
Eliminate or reformulate ultra-processed foods? Biological mechanisms matter	49