OOIR: Observatory of International Research

Papers

(The H4-Index of Nature Chemical Biology is 63. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-06-01 to 2025-06-01.)

Article	Citations
Making a 6mA demethylase	212
Chemical targeting of amyloids	208
To TnpB or not TnpB? Cas12 is the answer	185
Channeling kynurenine	183
Detecting features of antibody structure through their mediator-accessible redox activities	177
Cyclic signature	175
A sulfate amuse-bouche	175
Surviving salt stress	156
A vicious cycle	151
Development of cyclic peptides that can be administered orally to inhibit disease targets	151
Flipping the polarity switch	150
Sterol homeostasis in yeast	140
Altering the cap	136
Sensing the air	115
Seeing the retention	113
Assembly-activated aggregation	112
Publisher Correction: Accelerated RNA detection using tandem CRISPR nucleases	107
E2–Ub-R74G strategy reveals E2-specific ubiquitin conjugation profiles in live cells	106
Bacteria lose a pep in their step	103
Macrolones target bacterial ribosomes and DNA gyrase and can evade resistance mechanisms	102
Determining the role of peroxidation of subcellular lipid membranes in ferroptosis	102
Programmable living assembly of materials by bacterial adhesion	99
Author Correction: ML-enhanced peroxisome capacity enables compartmentalization of multienzyme pathway	98
Lysosome-targeting chimeras evolve	97
The landscape of targets and lead molecules for remyelination	97

Small-molecule dissolution of stress granules by redox modulation benefits ALS models	92
Rationally seeded computational protein design of ɑ-helical barrels	90
Characterization of a patient-derived variant of GPX4 for precision therapy	87
Inter-kingdom electromechanical communication	86
Engineering eukaryotic transposon-encoded Fanzor2 system for genome editing in mammals	85
Artificial intelligence foundation for therapeutic science	84
Lysine l-lactylation is the dominant lactylation isomer induced by glycolysis	83
Chemigenetic indicators based on synthetic chelators and green fluorescent protein	82
Calcium-gated potassium channel blockade via membrane-facing fenestrations	82
Facile generation of drug-like conformational antibodies specific for amyloid fibrils	82
An engineered trafficking biosensor reveals a role for DNAJC13 in DOR downregulation	81
Ribosome stalling during selenoprotein translation exposes a ferroptosis vulnerability	81
Ubiquitin-specific proximity labeling for the identification of E3 ligase substrates	80
Chemical genomics with pyrvinium identifies C1orf115 as a regulator of drug efflux	77
A class of anti-inflammatory lipids decrease with aging in the central nervous system	77
Small-molecule trapping of an RNA-binding protein blocks cancer cell growth	76
Seismic shift	76
Brake disposal	75
Controlling sulfation	75
Running through the blocks	75
The core of the matter	75
Small molecule targeting of chromatin writers in cancer	73
Badminton at nanoscale	72
Peptides hit the catalysis walk	71
Programmed RNA editing with an evolved bacterial adenosine deaminase	70
Tuned out	70
Making transient complexes stick	70
Visualizing drug effects over time in live animals using optical pharmacodynamics	69
A wrench in the motor	69
Small molecule inhibits KCNQ channels with a non-blocking mechanism	68
Discovery and molecular basis of subtype-selective cyclophilin inhibitors	68
Development of an allosteric adhesion GPCR nanobody with therapeutic potential	67
Engineering CAR-T cells to activate small-molecule drugs in situ	66
Endogenous currents in HEK 293 cells are inhibited by memantine	66
Autoinducer-fluorophore conjugates enable FRET in LuxR proteins in vitro and in cells	64
A high-throughput screening platform for enzymes active on mucin-type O-glycoproteins	64
M24B aminopeptidase inhibitors selectively activate the CARD8 inflammasome	63
Etoposide promotes DNA loop trapping and barrier formation by topoisomerase II	63