OOIR: Observatory of International Research

Papers

(The H4-Index of Nature Chemical Biology is 66. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2022-01-01 to 2026-01-01.)

Article	Citations
Flipping the polarity switch	307
Altering the cap	262
Sensing the air	238
Cyclic signature	207
Making a 6mA demethylase	184
Development of cyclic peptides that can be administered orally to inhibit disease targets	182
Chemical targeting of amyloids	173
To TnpB or not TnpB? Cas12 is the answer	152
Channeling kynurenine	151
Bacteria lose a pep in their step	144
A vicious cycle	144
Assembly-activated aggregation	142
Seeing the retention	129
Detecting features of antibody structure through their mediator-accessible redox activities	128
Facile generation of drug-like conformational antibodies specific for amyloid fibrils	126
Inter-kingdom electromechanical communication	125
E2–Ub-R74G strategy reveals E2-specific ubiquitin conjugation profiles in live cells	124
An engineered trafficking biosensor reveals a role for DNAJC13 in DOR downregulation	123
The landscape of targets and lead molecules for remyelination	122
Author Correction: ML-enhanced peroxisome capacity enables compartmentalization of multienzyme pathway	115
Calcium-gated potassium channel blockade via membrane-facing fenestrations	115
Chemigenetic indicators based on synthetic chelators and green fluorescent protein	110
Determining the role of peroxidation of subcellular lipid membranes in ferroptosis	107
Sterol homeostasis in yeast	106
Ubiquitin-specific proximity labeling for the identification of E3 ligase substrates	103

Small-molecule dissolution of stress granules by redox modulation benefits ALS models	100
Rationally seeded computational protein design of ɑ-helical barrels	99
Macrolones target bacterial ribosomes and DNA gyrase and can evade resistance mechanisms	95
Surviving salt stress	94
Engineering eukaryotic transposon-encoded Fanzor2 system for genome editing in mammals	93
A pseudoenzyme enables indole biosynthesis in eudicot plants	91
Ribosome stalling during selenoprotein translation exposes a ferroptosis vulnerability	90
Lysine l-lactylation is the dominant lactylation isomer induced by glycolysis	90
Chemical genomics with pyrvinium identifies C1orf115 as a regulator of drug efflux	88
A class of anti-inflammatory lipids decrease with aging in the central nervous system	88
Artificial intelligence foundation for therapeutic science	87
Small-molecule trapping of an RNA-binding protein blocks cancer cell growth	87
ALFA nanobody-guided endogenous labeling	87
Controlling sulfation	86
Seismic shift	86
Making transient complexes stick	85
Peptides hit the catalysis walk	84
Visualizing drug effects over time in live animals using optical pharmacodynamics	84
Tuned out	84
Brake disposal	82
Badminton at nanoscale	82
Running through the blocks	81
Endogenous currents in HEK 293 cells are inhibited by memantine	79
Site-specific encoding of photoactivity and photoreactivity into antibody fragments	78
Autoinducer-fluorophore conjugates enable FRET in LuxR proteins in vitro and in cells	78
Open-ended molecular recording of sequential cellular events into DNA	78
A super protein evolution engine	78
Discovery and molecular basis of subtype-selective cyclophilin inhibitors	77
Functional profiling of serine, threonine and tyrosine sites	76
Programmed RNA editing with an evolved bacterial adenosine deaminase	75
A high-throughput screening platform for enzymes active on mucin-type O-glycoproteins	74
Etoposide promotes DNA loop trapping and barrier formation by topoisomerase II	72
Development of an allosteric adhesion GPCR nanobody with therapeutic potential	71
Small molecule inhibits KCNQ channels with a non-blocking mechanism	71
An optimized bioluminescent substrate for non-invasive imaging in the brain	71
M24B aminopeptidase inhibitors selectively activate the CARD8 inflammasome	70
Oncometabolite 5-IP7 inhibits inositol 5-phosphatase to license E-cadherin endocytosis	70
SNAP-tag2 for faster and brighter protein labeling	70
Survival of the sweetest tooth	67
Degrade the RNA	67
Medicine from modified mRNA	66