Nature Chemical Biology

Papers
(The H4-Index of Nature Chemical Biology is 63. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-04-01 to 2025-04-01.)
ArticleCitations
Say yes to the NOS214
Peering into the cellular cycle190
Preserving the barrier183
Plasma membrane-associated ARAF condensates fuel RAS-related cancer drug resistance180
Turning down the heat177
Small molecules deliver big171
An engineered trafficking biosensor reveals a role for DNAJC13 in DOR downregulation163
Genes and crystals are not so separate159
Avoiding arm contact158
A versatile offense141
Protecting with PROTAC135
Cyclic signature135
Seeing the retention133
Spatiotemporally controlled generation of NTPs for single-molecule studies130
Programming cell-surface signaling by phase-separation-controlled compartmentalization128
Long-term super-resolution inner mitochondrial membrane imaging with a lipid probe124
Small molecule probes for targeting autophagy109
Converting non-neutralizing SARS-CoV-2 antibodies into broad-spectrum inhibitors108
Linked to death104
Metal to the pedal102
Your gut on steroids102
Cryptic enzymatic assembly of peptides armed with β-lactone warheads98
Plasmodesmata mediate cell-to-cell transport of brassinosteroid hormones97
Building light-activated synthetic cells that induce gene expression in bacteria via quorum sensing96
Rolling toward circular solutions95
Expanding the molecular grammar of polar residues and arginine in FUS phase separation93
Persistent activation of TRPM4 triggers necrotic cell death characterized by sodium overload89
Drugging viral factories86
Go with the FLOE86
A viscous switch85
Identifying p53-independent apoptosis85
Cutting the tail85
A Wittig combination85
A sulfate amuse-bouche82
Development of cyclic peptides that can be administered orally to inhibit disease targets79
A selective small-molecule STAT5 PROTAC degrader capable of achieving tumor regression in vivo77
Degradable living plastics programmed by engineered spores77
The ‘Big Bang’ of the chemical universe77
Identification and mechanism of G protein-biased ligands for chemokine receptor CCR176
Anti-aggregate activity75
Probiotic hat trick75
Breaking down taurine75
Ancient defensive terpene biosynthetic gene clusters in the soft corals75
Catalysis under stress75
Proximity-inducing pharmacology74
The acyl carrier protein dance74
Flipping the polarity switch73
Altering the cap72
A vicious cycle72
Choosing the junk71
Sensing the air70
Bacteria lose a pep in their step69
Accelerating enzyme evolution68
Surviving salt stress68
State of play68
The first step of hypusination67
The landscape of targets and lead molecules for remyelination66
Ub or not Ub66
Sterol homeostasis in yeast66
Systematic identification of biomarker-driven drug combinations to overcome resistance65
Author Correction: Hypercompact adenine base editors based on a Cas12f variant guided by engineered RNA64
Monoterpene metabolism unmasked64
Synergistic protection of nascent DNA at stalled forks by MSANTD4 and BRCA1/2–RAD5163
Traffic control63
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