Nature Chemical Biology

Article	Citations
Flipping the polarity switch	352
Altering the cap	273
Sensing the air	211
Cyclic signature	187
To TnpB or not TnpB? Cas12 is the answer	175
Development of cyclic peptides that can be administered orally to inhibit disease targets	175
Channeling kynurenine	171
Bacteria lose a pep in their step	159
Seeing the retention	152
Facile generation of drug-like conformational antibodies specific for amyloid fibrils	147
Inter-kingdom electromechanical communication	146
Ribosome stalling during selenoprotein translation exposes a ferroptosis vulnerability	144
Calcium-gated potassium channel blockade via membrane-facing fenestrations	143
Rapid evolution of a highly efficient RNA polymerase by homologous recombination	142
Chemical targeting of amyloids	141
Development of the fluorescent probe CenSpark for labeling centrioles and cilia	137
Making a 6mA demethylase	126
Complexoform-specific ligands that modulate the pleiotropic methyltransferase adaptor TRMT112	126
Author Correction: ML-enhanced peroxisome capacity enables compartmentalization of multienzyme pathway	119
Ubiquitin-specific proximity labeling for the identification of E3 ligase substrates	118
Chemical genomics with pyrvinium identifies C1orf115 as a regulator of drug efflux	117
A pseudoenzyme enables indole biosynthesis in eudicot plants	117
Rationally seeded computational protein design of ɑ-helical barrels	116
Lysine l-lactylation is the dominant lactylation isomer induced by glycolysis	114
E2–Ub-R74G strategy reveals E2-specific ubiquitin conjugation profiles in live cells	111

Small-molecule dissolution of stress granules by redox modulation benefits ALS models	107
Determining the role of peroxidation of subcellular lipid membranes in ferroptosis	106
Detecting features of antibody structure through their mediator-accessible redox activities	106
Artificial intelligence foundation for therapeutic science	106
The landscape of targets and lead molecules for remyelination	105
Sterol homeostasis in yeast	105
An engineered trafficking biosensor reveals a role for DNAJC13 in DOR downregulation	102
Engineering eukaryotic transposon-encoded Fanzor2 system for genome editing in mammals	99
ALFA nanobody-guided endogenous labeling	99
A class of anti-inflammatory lipids decrease with aging in the central nervous system	98
Macrolones target bacterial ribosomes and DNA gyrase and can evade resistance mechanisms	98
Surviving salt stress	97
Chemigenetic indicators based on synthetic chelators and green fluorescent protein	96
Seismic shift	93
Small-molecule trapping of an RNA-binding protein blocks cancer cell growth	93
Assembly-activated aggregation	93
Controlling sulfation	92
Making transient complexes stick	91
Small molecule inhibits KCNQ channels with a non-blocking mechanism	91
Peptides hit the catalysis walk	90
Tuned out	86
Brake disposal	85
Badminton at nanoscale	85
Running through the blocks	84
Open-ended molecular recording of sequential cellular events into DNA	83
Advances in BRET probes for intracellular target engagement studies	82
Endogenous currents in HEK 293 cells are inhibited by memantine	81
A super protein evolution engine	80
Visualizing drug effects over time in live animals using optical pharmacodynamics	79
Autoinducer-fluorophore conjugates enable FRET in LuxR proteins in vitro and in cells	78
Development of an allosteric adhesion GPCR nanobody with therapeutic potential	78
Etoposide promotes DNA loop trapping and barrier formation by topoisomerase II	77
Discovery and molecular basis of subtype-selective cyclophilin inhibitors	75
Functional profiling of serine, threonine and tyrosine sites	75
An evolution-conserved allosteric network in human tubulin governs paclitaxel efficacy	74
Programmed RNA editing with an evolved bacterial adenosine deaminase	74
Condensation-independent intramodular translocation mechanism of the trans-AT polyketide synthase assembly line	74
An optimized bioluminescent substrate for non-invasive imaging in the brain	73
Oncometabolite 5-IP7 inhibits inositol 5-phosphatase to license E-cadherin endocytosis	73
Site-specific encoding of photoactivity and photoreactivity into antibody fragments	72
SNAP-tag2 for faster and brighter protein labeling	71
A high-throughput screening platform for enzymes active on mucin-type O-glycoproteins	69
Survival of the sweetest tooth	69
Lighting up kinase contacts in situ	68
The right angle	67
Synthesizing cellular LOGIC	66
RNA-based programmable DNA cleavage	63
NO signal	63
Superbugs leave fingerprints	62
A home for orphans	62

Direct mapping of tyrosine sulfation states in native peptides by nanopore	61
Degrade the RNA	61
Affinity for both sides	61
Selective bioorthogonal probe for N-glycan hybrid structures	60
Lighting up hydrogen peroxide	60
All that glows is gold	60
Direct methylation sequencing	60
Improving phenotypic screening	58
Protein evolution as a complex system	57
Cas13d knockdown of lung protease Ctsl prevents and treats SARS-CoV-2 infection	57
Engineering APOBEC3A deaminase for highly accurate and efficient base editing	57
Medicine from modified mRNA	56
Programmable RNA base editing via targeted modifications	56
An unbiased proteomic platform for ATE1-based arginylation profiling	56
Structure and mechanism of a neuropeptide-activated channel in the ENaC/DEG superfamily	56
ML-enhanced peroxisome capacity enables compartmentalization of multienzyme pathway	55
Structural basis of efficacy-driven ligand selectivity at GPCRs	55
Molecular basis of β-arrestin coupling to the metabotropic glutamate receptor mGlu3	54
Mucin O-glycans are natural inhibitors of Candida albicans pathogenicity	54
Condensation of SEUSS promotes hyperosmotic stress tolerance in Arabidopsis	54
Deep learning-guided discovery of an antibiotic targeting Acinetobacter baumannii	53
Pharmacological targeting of BMAL1 modulates circadian and immune pathways	53
Engineering a xylose fermenting yeast for lignocellulosic ethanol production	53
Functional targeting of membrane transporters and enzymes to peroxisomes	52
Hydroxytryptophan biosynthesis by a family of heme-dependent enzymes in bacteria	52
Single-cell sensor analyses reveal signaling programs enabling Ras-G12C drug resistance	52
Prospering phase separation	51
Catch in nucleus	51
Dissociation for living	51
Providing inclusivity	51
Illuminating GPCR trafficking	51
Switching off the stress response	51
Chemically inducible split protein regulators for mammalian cells	50
Phase in phase	50
A peptide dehydratase with core strength	50
ALDH2-mediated GABA biosynthesis regulates hippocampal LTP and learning adaptability	49
Publisher Correction: Mutant p53 protein accumulation is selectively targetable by proximity-inducing drugs	49
Author Correction: Phage-assisted evolution of compact Cas9 variants targeting a simple NNG PAM	49
A fat-fueled fatality	48
Helping sperm keep the beat	48
A dimeric proteomimetic prevents SARS-CoV-2 infection by dimerizing the spike protein	47
Writing the CRBN degron	47
Boric acid intercepts 80S ribosome migration from AUG-stop by stabilizing eRF1	47
Anti-infective bile acids bind and inactivate a Salmonella virulence regulator	46
Chemical-based epigenetic reprogramming to advance pluripotency and totipotency	46
Dynamic basis for dA•dGTP and dA•d8OGTP misincorporation via Hoogsteen base pairs	46
Abasic CRISPR RNAs inherently harness fidelity of SpCas9 for genome editing	46
Structural snapshots along K48-linked ubiquitin chain formation by the HECT E3 UBR5	46
Interactions with tau’s microtubule-binding repeats modulate amyloid-β aggregation and toxicity	46
A rapid chemical reprogramming system to generate human pluripotent stem cells	45
Site-selective protein editing by backbone extension acyl rearrangements	45
Unfreezing structural biology for drug discovery	45
Chemically engineered antibodies for autophagy-based receptor degradation	45
The β-subunit of tryptophan synthase is a latent tyrosine synthase	44
Inhibition of translation termination by the antimicrobial peptide Drosocin	44
Signal peptide mimicry primes Sec61 for client-selective inhibition	43
A CRISPR activation screen identifies FBXO22 supporting targeted protein degradation	43
In-cell kinetic stability is an essential trait in metallo-β-lactamase evolution	43
A single-component, light-assisted uncaging switch for endoproteolytic release	43
Size matters	42
Under pressure	42
Genome mining for unknown–unknown natural products	42
Deep dive into a drug pump	42
Expanding beyond the capability of nature	42
Capturing receptor states with glue	42
ENO1 promotes liver carcinogenesis through YAP1-dependent arachidonic acid metabolism	42
Lighting up DNA	42
Chemical Decoding of Spatial Biology	41
Lipoyl deglutarylation by ABHD11 regulates mitochondrial and T cell metabolism	41
Author Correction: An engineered hypercompact CRISPR-Cas12f system with boosted gene-editing activity	41
Disarming the pathogen	41
Melting KRAS resistance	41
A PASS for protein secretion	40
Imbuing peptide libraries with drug-likeness	40
The realization of CRISPR gene therapy	40
A tungstopterin-containing enzyme has a key role in microbial ethanol biosynthesis	40
Forced rewiring of RTK signaling	39
Publisher Correction: Polyvalent folate receptor-targeting chimeras for degradation of membrane proteins	39
Bending insulin signals	39
Dissolution of oncofusion transcription factor condensates for cancer therapy	39

Thoughts for the future	39
Structural basis of TRPV3 inhibition by an antagonist	39
Alzheimer’s disease–implicated protein tau puts the squeeze on microtubules	38
An allosteric redox switch involved in oxygen protection in a CO2 reductase	38
Spontaneously established syntrophic yeast communities improve bioproduction	37
When membrane proteins prefer lipids	37
Nanopore glycan profiling	36
Structural basis of AcrIF24 as an anti-CRISPR protein and transcriptional suppressor	36
CRISPR–Cas12a-mediated DNA clamping triggers target-strand cleavage	36
Molecular basis for ubiquitin/Fubi cross-reactivity in USP16 and USP36	36
Rapid discovery of cyclic peptide protein aggregation inhibitors by continuous selection	36
Hippo pathway regulation by phosphatidylinositol transfer protein and phosphoinositides	36
Mechanism of nucleosomal H2A K13/15 monoubiquitination and adjacent dual monoubiquitination by RNF168	36
Structural mechanisms of TRPV2 modulation by endogenous and exogenous ligands	36
Shackled ribosomes unleashed	35
A modification-centric assessment tool for the performance of chemoproteomic probes	35
Genetically engineered synthetic cells activate cargo release upon temperature shift	34
Engineering from evolution	34
Redefining the off switch	34
Moonlighting in the membrane	34
Click, release, destroy	34
Studying ATP synthesis in situ	33
An alternative mechanism for recruiting Cas2/3 in a phage-encoded CRISPR–Cas system	33
A single sensor controls large variations in zinc quotas in a marine cyanobacterium	33
Basket of sweets	33
Drug addiction unveils a repressive methylation ceiling in EZH2-mutant lymphoma	32
Receptors from an ADAR trick	32
Programmable translation	32
A new class of macrocyclic peptides	32
Auxin branches out	32
Enhancing RNA base editing on mammalian transcripts with small nuclear RNAs	32
Engineered bacterial swarm patterns as spatial records of environmental inputs	32
Exchange coupling	32
Enzymatic synthesis of peptide therapeutics	32
Bringing chemistry to medicine to redefine the undruggable	32
Evading resistance at the double	31
Click biology highlights the opportunities from reliable biological reactions	31
Unbalanced response to growth variations reshapes the cell fate decision landscape	31
Chemical editing of proteoglycan architecture	31
De novo development of small cyclic peptides that are orally bioavailable	31
Programming biological communication between distinct membraneless compartments	31
A Ψ–Ψ codon–anticodon pairing in nonsense suppression and translational recoding	31
Structures of ALG3/9/12 reveal the assembly logic of the N-glycan oligomannose core	31
Empowering drug innovation through fundamental RNA research in China	31
Author Correction: A cell-free biosensor signal amplification circuit with polymerase strand recycling	31
Shifting redox reaction equilibria on demand using an orthogonal redox cofactor	31
Small-molecule inhibition of the archetypal UbiB protein COQ8	31
Structural basis of a small monomeric Clivia fluorogenic RNA with a large Stokes shift	31
Selective targeting of oncogenic hotspot mutations of the HER2 extracellular domain	31
In search of chemical rationales	30
TMEM164 is an acyltransferase that forms ferroptotic C20:4 ether phospholipids	30
Building light-activated synthetic cells that induce gene expression in bacteria via quorum sensing	30
State of play	30
Recording calcium concentrations	30
Traffic control	30
Aiming for the pocket	30
Identifying p53-independent apoptosis	29
GA-independent DELLA regulation by inositol pyrophosphate in a nonvascular land plant	29
The protein universe in 3D	29
Non-heme iron enzymes step into the spotlight	29
Context-based sensing of orthosomycin antibiotics by the translating ribosome	29
Artificial intelligence uncovers carcinogenic human metabolites	29
Learning from CoQ10 history	29
Friends, foes and signals	29
Proximity-inducing pharmacology	29
In silico prohormone processing	29
Partitioning of a 2-bit hash function across 66 communicating cells	29
Complex-specific inhibitors for interrogating ATAC histone acetyltransferase complex	29
Design principles imprinted by evolution	29
Depletion of creatine phosphagen energetics with a covalent creatine kinase inhibitor	29
Capturing copper to inhibit inflammation	29
Cryptic enzymatic assembly of peptides armed with β-lactone warheads	29
Antibodies expand the scope of angiotensin receptor pharmacology	29
Programmable solid-state condensates for spatiotemporal control of mammalian gene expression	29
Microtubule depolymerization at kinetochores restricts anaphase spindle elongation	28
Site-resolved energetic information from HX–MS experiments	28
A familiar newcomer to the thermogenetic toolset	28
Expanding the molecular grammar of polar residues and arginine in FUS phase separation	28
MESH1 functions as a metazoan PAPS phosphatase to regulate sulfation	28
A cold semi-swap	28
Long-term super-resolution inner mitochondrial membrane imaging with a lipid probe	27
A new twist to increase ion flow	27
Insights into G-protein coupling preference from cryo-EM structures of Gq-bound PTH1R	27
Velcrin-induced selective cleavage of tRNALeu(TAA) by SLFN12 causes cancer cell death	27
A gut feeling	27
Mechanism of capsaicin entry into buried vanilloid sites in TRPV1	27
PRMT inhibition induces a viral mimicry response in triple-negative breast cancer	27
Small molecule agonist of mitochondrial fusion repairs mitochondrial dysfunction	26
Transcriptional regulation of living materials via extracellular electron transfer	26
Old path, new frontier	26
Chemical screening by time-resolved X-ray scattering to discover allosteric probes	26
The chemical language of protein glycation	26
cIAP1-based degraders induce degradation via branched ubiquitin architectures	26
Pharmacological inhibition of Kir4.1 evokes rapid-onset antidepressant responses	26
RAS signaling gets granular	26