Nature Chemical Biology

Article	Citations
Say yes to the NOS	214
Peering into the cellular cycle	190
Preserving the barrier	183
Plasma membrane-associated ARAF condensates fuel RAS-related cancer drug resistance	180
Turning down the heat	177
Small molecules deliver big	171
An engineered trafficking biosensor reveals a role for DNAJC13 in DOR downregulation	163
Genes and crystals are not so separate	159
Avoiding arm contact	158
A versatile offense	141
Protecting with PROTAC	135
Cyclic signature	135
Seeing the retention	133
Spatiotemporally controlled generation of NTPs for single-molecule studies	130
Programming cell-surface signaling by phase-separation-controlled compartmentalization	128
Long-term super-resolution inner mitochondrial membrane imaging with a lipid probe	124
Small molecule probes for targeting autophagy	109
Converting non-neutralizing SARS-CoV-2 antibodies into broad-spectrum inhibitors	108
Linked to death	104
Metal to the pedal	102
Your gut on steroids	102
Cryptic enzymatic assembly of peptides armed with β-lactone warheads	98
Plasmodesmata mediate cell-to-cell transport of brassinosteroid hormones	97
Building light-activated synthetic cells that induce gene expression in bacteria via quorum sensing	96
Rolling toward circular solutions	95

Expanding the molecular grammar of polar residues and arginine in FUS phase separation	93
Persistent activation of TRPM4 triggers necrotic cell death characterized by sodium overload	89
Drugging viral factories	86
Go with the FLOE	86
Cutting the tail	85
A Wittig combination	85
A viscous switch	85
Identifying p53-independent apoptosis	85
A sulfate amuse-bouche	82
Development of cyclic peptides that can be administered orally to inhibit disease targets	79
Degradable living plastics programmed by engineered spores	77
The ‘Big Bang’ of the chemical universe	77
A selective small-molecule STAT5 PROTAC degrader capable of achieving tumor regression in vivo	77
Identification and mechanism of G protein-biased ligands for chemokine receptor CCR1	76
Anti-aggregate activity	75
Probiotic hat trick	75
Breaking down taurine	75
Ancient defensive terpene biosynthetic gene clusters in the soft corals	75
Catalysis under stress	75
Proximity-inducing pharmacology	74
The acyl carrier protein dance	74
Flipping the polarity switch	73
Altering the cap	72
A vicious cycle	72
Choosing the junk	71
Sensing the air	70
Bacteria lose a pep in their step	69
Accelerating enzyme evolution	68
Surviving salt stress	68
State of play	68
The first step of hypusination	67
Ub or not Ub	66
Sterol homeostasis in yeast	66
The landscape of targets and lead molecules for remyelination	66
Systematic identification of biomarker-driven drug combinations to overcome resistance	65
Monoterpene metabolism unmasked	64
Author Correction: Hypercompact adenine base editors based on a Cas12f variant guided by engineered RNA	64
Synergistic protection of nascent DNA at stalled forks by MSANTD4 and BRCA1/2–RAD51	63
Traffic control	63
Lifetime of ground conformational state determines the activity of structured RNA	62
PROTAR Vaccine 2.0 generates influenza vaccines by degrading multiple viral proteins	62
xrRNAs adopt a long-lived conformation that prevents exonuclease activity	61
E2–Ub-R74G strategy reveals E2-specific ubiquitin conjugation profiles in live cells	61
Lights on for lipid metabolism	60
Programmable solid-state condensates for spatiotemporal control of mammalian gene expression	60
A place to dock	60
An RNA aptamer that shifts the reduction potential of metabolic cofactors	59
Structure and mechanism of the methyltransferase ribozyme MTR1	58
20 years of Nature Chemical Biology	57
Structure and mechanism of a methyltransferase ribozyme	56

Target deconvolution of HDAC pharmacopoeia reveals MBLAC2 as common off-target	56
Recording calcium concentrations	55
An E. coli display method for characterization of peptide–sensor kinase interactions	53
Partitioning of a 2-bit hash function across 66 communicating cells	53
Macroscopic quorum sensing sustains differentiating embryonic stem cells	53
Cas1 mediates the interference stage in a phage-encoded CRISPR–Cas system	53
Coaching LSD1 to ignore acetylation	53
Author Correction: Balancing G protein selectivity and efficacy in the adenosine A2A receptor	52
Nonmonotone invasion landscape by noise-aware control of metastasis activator levels	52
Mining microbial metabolism	52
Evolutionary balance between foldability and functionality of a glucose transporter	51
Detecting features of antibody structure through their mediator-accessible redox activities	51
A new road to STING activation	51
In search of chemical rationales	50
Flipping the switch	50
Sinking the carrier	49
Artificial intelligence uncovers carcinogenic human metabolites	49
Toying with reductive stress	49
Chemical targeting of amyloids	49
Change can be SCARI	48
Targeting lipid–protein interaction to treat Syk-mediated acute myeloid leukemia	48
The role of G protein conformation in receptor–G protein selectivity	47
Depletion of creatine phosphagen energetics with a covalent creatine kinase inhibitor	47
CRISP(e)R drug discovery	47
Making a 6mA demethylase	46
Discovery of VH domains that allosterically inhibit ENPP1	46
Immobilized enzyme cascade for targeted glycosylation	46
Sampling the rainbow	46
Bump-hole ZDHHCs	45
Addendum: Designing microbial consortia with defined social interactions	45
Motif-dependent binding on the intervening domain regulates O-GlcNAc transferase	45
The protein universe in 3D	45
Author Correction: ML-enhanced peroxisome capacity enables compartmentalization of multienzyme pathway	45
A chemical probe targeting the PWWP domain alters NSD2 nucleolar localization	44
Rationally seeded computational protein design of ɑ-helical barrels	43
Controllable genome editing with split-engineered base editors	42
Publisher Correction: Accelerated RNA detection using tandem CRISPR nucleases	42
Rapid generation of potent antibodies by autonomous hypermutation in yeast	42
Enzymatic assembly of the salinosporamide γ-lactam-β-lactone anticancer warhead	42
Lysosome-targeting chimeras evolve	42
A roadmap to creating ferroptosis-based medicines	42
Channeling kynurenine	42
Aiming for the pocket	41
Author Correction: Making a 6mA demethylase	40
Ribosome stalling during selenoprotein translation exposes a ferroptosis vulnerability	39
Context-based sensing of orthosomycin antibiotics by the translating ribosome	39
Chemical genomics with pyrvinium identifies C1orf115 as a regulator of drug efflux	39
Author Correction: Genome-wide screens uncover KDM2B as a modifier of protein binding to heparan sulfate	39
Caught in the act	39
Discovery and biosynthesis of cyclic plant peptides via autocatalytic cyclases	39
Author Correction: Selective inhibitors of JAK1 targeting an isoform-restricted allosteric cysteine	39
Author Correction: Structure and mechanism of a methyltransferase ribozyme	39
Author Correction: O-GlcNAc forces an α-synuclein amyloid strain with notably diminished seeding and pathology	38
To TnpB or not TnpB? Cas12 is the answer	37
Antibody discovery identifies regulatory mechanisms of protein arginine deiminase 4	37
Structure and catalytic activity of the SAM-utilizing ribozyme SAMURI	36
Determining the role of peroxidation of subcellular lipid membranes in ferroptosis	36
Engineering covalent small molecule–RNA complexes in living cells	36
Design of amyloidogenic peptide traps	36
Molecular mechanisms of inverse agonism via κ-opioid receptor–G protein complexes	36
Calcium-gated potassium channel blockade via membrane-facing fenestrations	36
Paenilamicins bind to a unique site on the ribosome to inhibit protein synthesis	35
Assembly-activated aggregation	35
Balancing G protein selectivity and efficacy in the adenosine A2A receptor	35
Hydrogel-based biocontainment of bacteria for continuous sensing and computation	35
Combining CRISPRi and metabolomics for functional annotation of compound libraries	35
Protein Degradation in Focus	34
Fast and sensitive CRISPR detection by minimized interference of target amplification	34
Molecular basis of threonine ADP-ribosylation of ubiquitin by bacterial ARTs	34
Biocatalytic cyclization of small macrolactams by a penicillin-binding protein-type thioesterase	34
Velcrin-induced selective cleavage of tRNALeu(TAA) by SLFN12 causes cancer cell death	33
A brief guideline for studies of phase-separated biomolecular condensates	33
Macrolones target bacterial ribosomes and DNA gyrase and can evade resistance mechanisms	33
A class of anti-inflammatory lipids decrease with aging in the central nervous system	33
Quantitative profiling of pseudouridylation landscape in the human transcriptome	32
Adaptive mechanisms of plant specialized metabolism connecting chemistry to function	32
Characterization of a patient-derived variant of GPX4 for precision therapy	32
Programmable living assembly of materials by bacterial adhesion	32
MNK2 deficiency potentiates β-cell regeneration via translational regulation	31
Artificial intelligence foundation for therapeutic science	31

A helical fulcrum in eIF2B coordinates allosteric regulation of stress signaling	31
Capturing copper to inhibit inflammation	31
Inter-kingdom electromechanical communication	31
Endogenous cell membrane interactome mapping for the GLP-1 receptor in different cell types	31
Antibodies expand the scope of angiotensin receptor pharmacology	31
Genetic-code-expanded cell-based therapy for treating diabetes in mice	31
Unlocking saponin biosynthesis in soapwort	31
Ubiquitin-specific proximity labeling for the identification of E3 ligase substrates	30
De novo design of buttressed loops for sculpting protein functions	30
Sensitive fluorescent biosensor reveals differential subcellular regulation of PKC	30
Programming cell-free biosensors with DNA strand displacement circuits	30
The HaloTag as a general scaffold for far-red tunable chemigenetic indicators	29
Genome-wide screens uncover KDM2B as a modifier of protein binding to heparan sulfate	29
Chemigenetic indicators based on synthetic chelators and green fluorescent protein	29
A structural basis for prion strain diversity	29
PAFAH2 suppresses synchronized ferroptosis to ameliorate acute kidney injury	29
Learning from CoQ10 history	29
CRISPR–dCas12a-mediated genetic circuit cascades for multiplexed pathway optimization	28
An anti-biofilm cyclic peptide targets a secreted aminopeptidase from P. aeruginosa	28
PRMT inhibition induces a viral mimicry response in triple-negative breast cancer	28
Lysine l-lactylation is the dominant lactylation isomer induced by glycolysis	28
Strategies for monitoring cell–cell interactions	28
Engineered LwaCas13a with enhanced collateral activity for nucleic acid detection	28
Micropolarity governs the structural organization of biomolecular condensates	28
De novo designed peptides for cellular delivery and subcellular localisation	28
Controlling sulfation	27
Scrambling viral infection	27
Cascading conjugates	27
Cyclic nucleotides in for the kill	27
Seismic shift	27
One-site ‘-omics’	27
Shape matching	27
Put another ring on it	27
Changing plates	27
Molecular mechanism of allosteric modulation for the cannabinoid receptor CB1	27
Untying knots with force	27
Translating repair	27
Mucin tuning	26
Efficiency by location	26
Compromised autophagy	26
A chilling effect	26
A new entry point	26
TIRs on my pillow	26
Picking off persisters	26
Clearing the path	26
A molecular shape-shifter	26
Adjusting the spikes	26
An antibacterial glove	25
Molecular conversations	25
Brake disposal	25
Badminton at nanoscale	25
Discovering new biology with drug-resistance alleles	25
Running through the blocks	25
It’s in the blood	25
Small-molecule trapping of an RNA-binding protein blocks cancer cell growth	25
Proteins dance to the tune of light	24
The chemical language of protein glycation	24
Phasing out death	24
Bridging the gap in protein targeting	24
How nature ties peptide knots	24
Cobalamin in charge	24
Seeing α-synuclein fibrils	24
Molecular glue modulates mitochondria	24
The core of the matter	24
The impact of library size and scale of testing on virtual screening	24
An intramolecular macrocyclase in plant ribosomal peptide biosynthesis	23
LIS1 (Pac1) binding slows dissociation of dynein from microtubules	23
Small molecule inhibits KCNQ channels with a non-blocking mechanism	23
Putting peptides on display	23
Catalytic-independent functions of the Integrator–PP2A complex (INTAC) confer sensitivity to BET inhibition	23
Aerobic glycolysis comes with an enzyme cost but robustness gain	23
Stress it up	23
Trapping the helicase	23
A new RNA performs old chemistry	23
Time-resolved HT-SAXS discovers allosteric chemotypes for redox target AIF	23
Simultaneous multi-site editing of individual genomes using retron arrays	22
Sentinel cells programmed to respond to environmental DNA including human sequences	22
Engineering CAR-T cells to activate small-molecule drugs in situ	22
CAR-T cells SEAK help from enzymes	22
Brassinosteroids en route	22
Programmed RNA editing with an evolved bacterial adenosine deaminase	22
Site-specific encoding of photoactivity and photoreactivity into antibody fragments	22
Spatiotemporal dynamics of focal adhesion kinase	22
Monitoring lysosomal acidity	21
Protein-based bandpass filters for controlling cellular signaling with chemical inputs	21
Author Correction: Histone tyrosine sulfation by SULT1B1 regulates H4R3me2a and gene transcription	21
Molecular basis for the selective G protein signaling of somatostatin receptors	21
Structural insight into selectivity of amylin and calcitonin receptor agonists	21
The eRF1 degrader SRI-41315 acts as a molecular glue at the ribosomal decoding center	21
Tuned out	21
Endosome positioning coordinates spatially selective GPCR signaling	21
A high-throughput screening platform for enzymes active on mucin-type O-glycoproteins	21
Distinct phases of cellular signaling revealed by time-resolved protein synthesis	21
Accelerating the design of pili-enabled living materials using an integrative technological workflow	21
A new twist to increase ion flow	21