Nature Chemical Biology

Article	Citations
Flipping the polarity switch	290
Altering the cap	245
Sensing the air	219
A sulfate amuse-bouche	204
Cyclic signature	189
Surviving salt stress	174
Making a 6mA demethylase	173
Development of cyclic peptides that can be administered orally to inhibit disease targets	167
Chemical targeting of amyloids	141
Channeling kynurenine	140
To TnpB or not TnpB? Cas12 is the answer	140
A vicious cycle	134
Bacteria lose a pep in their step	129
Assembly-activated aggregation	120
Seeing the retention	118
Macrolones target bacterial ribosomes and DNA gyrase and can evade resistance mechanisms	116
Small-molecule dissolution of stress granules by redox modulation benefits ALS models	116
The landscape of targets and lead molecules for remyelination	115
Lysine l-lactylation is the dominant lactylation isomer induced by glycolysis	114
Artificial intelligence foundation for therapeutic science	112
A pseudoenzyme enables indole biosynthesis in eudicot plants	107
ALFA nanobody-guided endogenous labeling	107
Inter-kingdom electromechanical communication	101
E2–Ub-R74G strategy reveals E2-specific ubiquitin conjugation profiles in live cells	100
An engineered trafficking biosensor reveals a role for DNAJC13 in DOR downregulation	99

Calcium-gated potassium channel blockade via membrane-facing fenestrations	95
Determining the role of peroxidation of subcellular lipid membranes in ferroptosis	95
Engineering eukaryotic transposon-encoded Fanzor2 system for genome editing in mammals	94
Detecting features of antibody structure through their mediator-accessible redox activities	92
Chemical genomics with pyrvinium identifies C1orf115 as a regulator of drug efflux	91
Chemigenetic indicators based on synthetic chelators and green fluorescent protein	90
Facile generation of drug-like conformational antibodies specific for amyloid fibrils	88
Sterol homeostasis in yeast	87
Rationally seeded computational protein design of ɑ-helical barrels	86
Characterization of a patient-derived variant of GPX4 for precision therapy	84
Programmable living assembly of materials by bacterial adhesion	84
A class of anti-inflammatory lipids decrease with aging in the central nervous system	84
Ubiquitin-specific proximity labeling for the identification of E3 ligase substrates	84
Ribosome stalling during selenoprotein translation exposes a ferroptosis vulnerability	84
Small-molecule trapping of an RNA-binding protein blocks cancer cell growth	82
Author Correction: ML-enhanced peroxisome capacity enables compartmentalization of multienzyme pathway	82
Seismic shift	81
Controlling sulfation	80
Making transient complexes stick	79
Visualizing drug effects over time in live animals using optical pharmacodynamics	79
Oncometabolite 5-IP7 inhibits inositol 5-phosphatase to license E-cadherin endocytosis	78
Peptides hit the catalysis walk	77
Tuned out	77
Brake disposal	76
Badminton at nanoscale	76
Running through the blocks	76
Autoinducer-fluorophore conjugates enable FRET in LuxR proteins in vitro and in cells	75
Structure-based investigation of fluorogenic Pepper aptamer	74
Development of an allosteric adhesion GPCR nanobody with therapeutic potential	73
An optimized bioluminescent substrate for non-invasive imaging in the brain	73
Endogenous currents in HEK 293 cells are inhibited by memantine	73
Programmed RNA editing with an evolved bacterial adenosine deaminase	72
Site-specific encoding of photoactivity and photoreactivity into antibody fragments	72
A wrench in the motor	71
Etoposide promotes DNA loop trapping and barrier formation by topoisomerase II	71
Small molecule targeting of chromatin writers in cancer	70
Small molecule inhibits KCNQ channels with a non-blocking mechanism	70
Functional profiling of serine, threonine and tyrosine sites	70
Open-ended molecular recording of sequential cellular events into DNA	68
SNAP-tag2 for faster and brighter protein labeling	68
Discovery and molecular basis of subtype-selective cyclophilin inhibitors	68
A high-throughput screening platform for enzymes active on mucin-type O-glycoproteins	68
M24B aminopeptidase inhibitors selectively activate the CARD8 inflammasome	67
Survival of the sweetest tooth	66
Degrade the RNA	66
Engineering CAR-T cells to activate small-molecule drugs in situ	66
Medicine from modified mRNA	65
Lighting up kinase contacts in situ	63
Waking sleeping viruses	63
Protein evolution as a complex system	63

Synthesizing cellular LOGIC	62
RNA-based programmable DNA cleavage	62
The right angle	62
Rolling the RBP snowballs	62
NO signal	62
A home for orphans	61
Selective bioorthogonal probe for N-glycan hybrid structures	60
Affinity for both sides	60
Superbugs leave fingerprints	60
Direct methylation sequencing	59
All that glows is gold	59
Engineering APOBEC3A deaminase for highly accurate and efficient base editing	57
Stepwise membrane binding of extended synaptotagmins revealed by optical tweezers	56
Structure and mechanism of a neuropeptide-activated channel in the ENaC/DEG superfamily	55
An unbiased proteomic platform for ATE1-based arginylation profiling	55
Lighting up hydrogen peroxide	55
Molecular basis of β-arrestin coupling to the metabotropic glutamate receptor mGlu3	53
Structural basis of efficacy-driven ligand selectivity at GPCRs	53
Direct mapping of tyrosine sulfation states in native peptides by nanopore	53
Single-cell sensor analyses reveal signaling programs enabling Ras-G12C drug resistance	52
Pharmacological targeting of BMAL1 modulates circadian and immune pathways	52
Cas13d knockdown of lung protease Ctsl prevents and treats SARS-CoV-2 infection	51
Condensation of SEUSS promotes hyperosmotic stress tolerance in Arabidopsis	51
Hydroxytryptophan biosynthesis by a family of heme-dependent enzymes in bacteria	51
Mucin O-glycans are natural inhibitors of Candida albicans pathogenicity	51
Deep learning-guided discovery of an antibiotic targeting Acinetobacter baumannii	50
Programmable RNA base editing via targeted modifications	50
Engineering a xylose fermenting yeast for lignocellulosic ethanol production	49
ML-enhanced peroxisome capacity enables compartmentalization of multienzyme pathway	49
Functional targeting of membrane transporters and enzymes to peroxisomes	49
Providing inclusivity	48
Switching off the stress response	48
Sweet synthetic chaperones	48
Catch in nucleus	48
Prospering phase separation	47
A fat-fueled fatality	47
Illuminating GPCR trafficking	47
Dissociation for living	46
A peptide dehydratase with core strength	46
Author Correction: Phage-assisted evolution of compact Cas9 variants targeting a simple NNG PAM	46
Dynamic basis for dA•dGTP and dA•d8OGTP misincorporation via Hoogsteen base pairs	45
A dimeric proteomimetic prevents SARS-CoV-2 infection by dimerizing the spike protein	45
Phase in phase	45
Signal peptide mimicry primes Sec61 for client-selective inhibition	45
Boric acid intercepts 80S ribosome migration from AUG-stop by stabilizing eRF1	45
Chemically engineered antibodies for autophagy-based receptor degradation	44
A CRISPR activation screen identifies FBXO22 supporting targeted protein degradation	44
Chemical-based epigenetic reprogramming to advance pluripotency and totipotency	44
Inhibition of translation termination by the antimicrobial peptide Drosocin	44
Site-selective protein editing by backbone extension acyl rearrangements	44
A single-component, light-assisted uncaging switch for endoproteolytic release	43
Anti-infective bile acids bind and inactivate a Salmonella virulence regulator	43
Interactions with tau’s microtubule-binding repeats modulate amyloid-β aggregation and toxicity	42
Genome mining for unknown–unknown natural products	42
ENO1 promotes liver carcinogenesis through YAP1-dependent arachidonic acid metabolism	42
A rapid chemical reprogramming system to generate human pluripotent stem cells	42
Structural snapshots along K48-linked ubiquitin chain formation by the HECT E3 UBR5	41
In-cell kinetic stability is an essential trait in metallo-β-lactamase evolution	40
Enzyme assemblies on demand	40
ALDH2-mediated GABA biosynthesis regulates hippocampal LTP and learning adaptability	40
Chemically inducible split protein regulators for mammalian cells	40
Alzheimer’s disease–implicated protein tau puts the squeeze on microtubules	40
The β-subunit of tryptophan synthase is a latent tyrosine synthase	40
Modulation of microbial community dynamics by spatial partitioning	40
Author Correction: An engineered hypercompact CRISPR-Cas12f system with boosted gene-editing activity	40
Nanopore glycan profiling	40
Lighting up DNA	39
Disarming the pathogen	39
Size matters	39
Capturing receptor states with glue	39
Under pressure	39
Deep dive into a drug pump	39
Expanding beyond the capability of nature	39
Chemical Decoding of Spatial Biology	38
Structural basis of AcrIF24 as an anti-CRISPR protein and transcriptional suppressor	38
Rapid discovery of cyclic peptide protein aggregation inhibitors by continuous selection	38
Structural basis of TRPV3 inhibition by an antagonist	38
Hippo pathway regulation by phosphatidylinositol transfer protein and phosphoinositides	37
Sialic acid-containing glycolipids mediate binding and viral entry of SARS-CoV-2	37
Mechanism of nucleosomal H2A K13/15 monoubiquitination and adjacent dual monoubiquitination by RNF168	37

A modification-centric assessment tool for the performance of chemoproteomic probes	37
Thoughts for the future	37
Structural basis for inhibition of the drug efflux pump NorA from Staphylococcus aureus	36
Spontaneously established syntrophic yeast communities improve bioproduction	36
Convergent evolution of bacterial ceramide synthesis	35
Melting KRAS resistance	35
Imbuing peptide libraries with drug-likeness	35
Lipoyl deglutarylation by ABHD11 regulates mitochondrial and T cell metabolism	35
An allosteric redox switch involved in oxygen protection in a CO2 reductase	35
A PASS for protein secretion	35
Molecular basis for ubiquitin/Fubi cross-reactivity in USP16 and USP36	35
The realization of CRISPR gene therapy	35
Dissolution of oncofusion transcription factor condensates for cancer therapy	35
Forced rewiring of RTK signaling	35
Click, release, destroy	34
CRISPR–Cas12a-mediated DNA clamping triggers target-strand cleavage	34
Genetically engineered synthetic cells activate cargo release upon temperature shift	34
Cross-kingdom warfare	34
Structural mechanisms of TRPV2 modulation by endogenous and exogenous ligands	34
Redefining the off switch	34
Shackled ribosomes unleashed	34
Publisher Correction: Polyvalent folate receptor-targeting chimeras for degradation of membrane proteins	34
Engineering from evolution	33
Author Correction: Combining CRISPRi and metabolomics for functional annotation of compound libraries	33
Bringing chemistry to medicine to redefine the undruggable	33
Moonlighting in the membrane	33
Basket of sweets	32
Evading resistance at the double	32
An alternative mechanism for recruiting Cas2/3 in a phage-encoded CRISPR–Cas system	32
Engineered bacterial swarm patterns as spatial records of environmental inputs	31
A new class of macrocyclic peptides	31
Studying ATP synthesis in situ	31
Enhancing RNA base editing on mammalian transcripts with small nuclear RNAs	31
Auxin branches out	30
De novo development of small cyclic peptides that are orally bioavailable	30
Enzymatic synthesis of peptide therapeutics	30
A single sensor controls large variations in zinc quotas in a marine cyanobacterium	30
Author Correction: A cell-free biosensor signal amplification circuit with polymerase strand recycling	30
Chemical editing of proteoglycan architecture	30
Click biology highlights the opportunities from reliable biological reactions	29
Receptors from an ADAR trick	29
Selective targeting of oncogenic hotspot mutations of the HER2 extracellular domain	29
Shifting redox reaction equilibria on demand using an orthogonal redox cofactor	29
Small-molecule inhibition of the archetypal UbiB protein COQ8	29
Drug addiction unveils a repressive methylation ceiling in EZH2-mutant lymphoma	29
Dynamic eIF3a O-GlcNAcylation controls translation reinitiation during nutrient stress	29
A Ψ–Ψ codon–anticodon pairing in nonsense suppression and translational recoding	29
Structural basis of a small monomeric Clivia fluorogenic RNA with a large Stokes shift	29
TMEM164 is an acyltransferase that forms ferroptotic C20:4 ether phospholipids	28
Cutting the tail	28
Programming biological communication between distinct membraneless compartments	28
In search of chemical rationales	28
Unbalanced response to growth variations reshapes the cell fate decision landscape	28
State of play	28
Identifying p53-independent apoptosis	27
Design principles imprinted by evolution	27
Learning from CoQ10 history	27
Context-based sensing of orthosomycin antibiotics by the translating ribosome	27
In silico prohormone processing	27
Proximity-inducing pharmacology	27
Depletion of creatine phosphagen energetics with a covalent creatine kinase inhibitor	27
Traffic control	27
Recording calcium concentrations	27
Aiming for the pocket	27
Site-resolved energetic information from HX–MS experiments	27
Programmable solid-state condensates for spatiotemporal control of mammalian gene expression	27
Building light-activated synthetic cells that induce gene expression in bacteria via quorum sensing	27
Catalysis under stress	27
Mechanism of capsaicin entry into buried vanilloid sites in TRPV1	27
Long-term super-resolution inner mitochondrial membrane imaging with a lipid probe	26
Insights into G-protein coupling preference from cryo-EM structures of Gq-bound PTH1R	26
Combining CRISPRi and metabolomics for functional annotation of compound libraries	26
PRMT inhibition induces a viral mimicry response in triple-negative breast cancer	26
Artificial intelligence uncovers carcinogenic human metabolites	26
Velcrin-induced selective cleavage of tRNALeu(TAA) by SLFN12 causes cancer cell death	26
Capturing copper to inhibit inflammation	26
GA-independent DELLA regulation by inositol pyrophosphate in a nonvascular land plant	26
Antibodies expand the scope of angiotensin receptor pharmacology	26
Expanding the molecular grammar of polar residues and arginine in FUS phase separation	26
Partitioning of a 2-bit hash function across 66 communicating cells	26
Discovery and biosynthesis of cyclic plant peptides via autocatalytic cyclases	26
Cryptic enzymatic assembly of peptides armed with β-lactone warheads	26
The protein universe in 3D	26
Non-heme iron enzymes step into the spotlight	26
A gut feeling	25
Stress it up	25
A complex struggle for direction	25
Drivers of intrinsic resistance	25
One-carbon footprint in B cells	25
A new twist to increase ion flow	25
Auto-inhibition and activation of a short Argonaute-associated TIR-APAZ defense system	25
It’s in the blood	25
A new RNA performs old chemistry	25
Serine ADPr on histones and PARP1 is a cellular target of ester-linked ubiquitylation	24
Horizontal gene transfer enables programmable gene stability in synthetic microbiota	24