Nature Chemical Biology

Papers
(The TQCC of Nature Chemical Biology is 19. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-07-01 to 2025-07-01.)
ArticleCitations
Making a 6mA demethylase219
Chemical targeting of amyloids218
To TnpB or not TnpB? Cas12 is the answer193
Detecting features of antibody structure through their mediator-accessible redox activities187
Channeling kynurenine187
A sulfate amuse-bouche181
Cyclic signature179
Surviving salt stress160
Development of cyclic peptides that can be administered orally to inhibit disease targets156
A vicious cycle155
Flipping the polarity switch151
Sterol homeostasis in yeast146
Altering the cap143
Sensing the air122
Seeing the retention117
Publisher Correction: Accelerated RNA detection using tandem CRISPR nucleases114
Assembly-activated aggregation114
Facile generation of drug-like conformational antibodies specific for amyloid fibrils107
Artificial intelligence foundation for therapeutic science105
Bacteria lose a pep in their step105
An engineered trafficking biosensor reveals a role for DNAJC13 in DOR downregulation104
Determining the role of peroxidation of subcellular lipid membranes in ferroptosis104
Author Correction: ML-enhanced peroxisome capacity enables compartmentalization of multienzyme pathway103
Lysosome-targeting chimeras evolve102
Engineering eukaryotic transposon-encoded Fanzor2 system for genome editing in mammals100
Inter-kingdom electromechanical communication94
Chemical genomics with pyrvinium identifies C1orf115 as a regulator of drug efflux93
A pseudoenzyme enables indole biosynthesis in eudicot plants92
Ubiquitin-specific proximity labeling for the identification of E3 ligase substrates89
Characterization of a patient-derived variant of GPX4 for precision therapy87
E2–Ub-R74G strategy reveals E2-specific ubiquitin conjugation profiles in live cells87
Rationally seeded computational protein design of ɑ-helical barrels86
Programmable living assembly of materials by bacterial adhesion85
The landscape of targets and lead molecules for remyelination85
Lysine l-lactylation is the dominant lactylation isomer induced by glycolysis83
Calcium-gated potassium channel blockade via membrane-facing fenestrations83
Ribosome stalling during selenoprotein translation exposes a ferroptosis vulnerability82
Small-molecule dissolution of stress granules by redox modulation benefits ALS models80
A class of anti-inflammatory lipids decrease with aging in the central nervous system79
Chemigenetic indicators based on synthetic chelators and green fluorescent protein78
Macrolones target bacterial ribosomes and DNA gyrase and can evade resistance mechanisms78
Seismic shift78
Small-molecule trapping of an RNA-binding protein blocks cancer cell growth77
The core of the matter76
Controlling sulfation76
Running through the blocks75
Brake disposal75
Peptides hit the catalysis walk72
Badminton at nanoscale72
Functional profiling of serine, threonine and tyrosine sites72
Making transient complexes stick71
Tuned out71
A high-throughput screening platform for enzymes active on mucin-type O-glycoproteins70
Discovery and molecular basis of subtype-selective cyclophilin inhibitors70
Visualizing drug effects over time in live animals using optical pharmacodynamics70
A wrench in the motor70
Autoinducer-fluorophore conjugates enable FRET in LuxR proteins in vitro and in cells68
Open-ended molecular recording of sequential cellular events into DNA67
M24B aminopeptidase inhibitors selectively activate the CARD8 inflammasome67
Development of an allosteric adhesion GPCR nanobody with therapeutic potential66
Endogenous currents in HEK 293 cells are inhibited by memantine64
Small molecule targeting of chromatin writers in cancer63
Etoposide promotes DNA loop trapping and barrier formation by topoisomerase II62
Engineering CAR-T cells to activate small-molecule drugs in situ62
Programmed RNA editing with an evolved bacterial adenosine deaminase62
Small molecule inhibits KCNQ channels with a non-blocking mechanism62
Structure-based investigation of fluorogenic Pepper aptamer62
Site-specific encoding of photoactivity and photoreactivity into antibody fragments61
An optimized bioluminescent substrate for non-invasive imaging in the brain60
Escherichia coli small molecule metabolism at the host–microorganism interface60
Survival of the sweetest tooth58
Medicine from modified mRNA58
Degrade the RNA58
Molecular basis of β-arrestin coupling to the metabotropic glutamate receptor mGlu357
Superbugs leave fingerprints57
Affinity for both sides56
Stepwise membrane binding of extended synaptotagmins revealed by optical tweezers56
NO signal55
Direct methylation sequencing55
Single-cell sensor analyses reveal signaling programs enabling Ras-G12C drug resistance55
Lighting up kinase contacts in situ55
RNA-based programmable DNA cleavage55
Waking sleeping viruses55
Programmable RNA base editing via targeted modifications55
Rolling the RBP snowballs55
Synthesizing cellular LOGIC55
A home for orphans55
All that glows is gold54
The right angle54
Structure and mechanism of a neuropeptide-activated channel in the ENaC/DEG superfamily53
Pharmacological targeting of BMAL1 modulates circadian and immune pathways53
ML-enhanced peroxisome capacity enables compartmentalization of multienzyme pathway52
Functional targeting of membrane transporters and enzymes to peroxisomes52
Engineering APOBEC3A deaminase for highly accurate and efficient base editing51
Direct mapping of tyrosine sulfation states in native peptides by nanopore51
Engineering a xylose fermenting yeast for lignocellulosic ethanol production51
Hydroxytryptophan biosynthesis by a family of heme-dependent enzymes in bacteria50
Selective bioorthogonal probe for N-glycan hybrid structures50
Condensation of SEUSS promotes hyperosmotic stress tolerance in Arabidopsis49
Structural basis of efficacy-driven ligand selectivity at GPCRs49
Mucin O-glycans are natural inhibitors of Candida albicans pathogenicity48
Cas13d knockdown of lung protease Ctsl prevents and treats SARS-CoV-2 infection48
Deep learning-guided discovery of an antibiotic targeting Acinetobacter baumannii48
Providing inclusivity47
Switching off the stress response47
Catch in nucleus46
Sweet synthetic chaperones46
Prospering phase separation45
Author Correction: Phage-assisted evolution of compact Cas9 variants targeting a simple NNG PAM45
A peptide dehydratase with core strength45
Chemical-based epigenetic reprogramming to advance pluripotency and totipotency44
Illuminating GPCR trafficking44
Dissociation for living44
A single-component, light-assisted uncaging switch for endoproteolytic release44
A fat-fueled fatality44
In-cell kinetic stability is an essential trait in metallo-β-lactamase evolution43
A dimeric proteomimetic prevents SARS-CoV-2 infection by dimerizing the spike protein43
Boric acid intercepts 80S ribosome migration from AUG-stop by stabilizing eRF143
Chemically inducible split protein regulators for mammalian cells43
Inhibition of translation termination by the antimicrobial peptide Drosocin43
The β-subunit of tryptophan synthase is a latent tyrosine synthase41
Chemically engineered antibodies for autophagy-based receptor degradation41
Modulation of microbial community dynamics by spatial partitioning40
Genome mining for unknown–unknown natural products40
Dynamic basis for dA•dGTP and dA•d8OGTP misincorporation via Hoogsteen base pairs40
Anti-infective bile acids bind and inactivate a Salmonella virulence regulator40
Phase in phase39
ENO1 promotes liver carcinogenesis through YAP1-dependent arachidonic acid metabolism39
Signal peptide mimicry primes Sec61 for client-selective inhibition39
CUL5-ARIH2 E3-E3 ubiquitin ligase structure reveals cullin-specific NEDD8 activation39
Structural snapshots along K48-linked ubiquitin chain formation by the HECT E3 UBR539
A CRISPR activation screen identifies FBXO22 supporting targeted protein degradation39
Deep dive into a drug pump38
Enzyme assemblies on demand38
Nanopore glycan profiling38
Size matters38
Alzheimer’s disease–implicated protein tau puts the squeeze on microtubules38
A rapid chemical reprogramming system to generate human pluripotent stem cells38
Capturing receptor states with glue38
Disarming the pathogen38
Lighting up DNA37
Expanding beyond the capability of nature37
Under pressure37
Author Correction: An engineered hypercompact CRISPR-Cas12f system with boosted gene-editing activity37
Imbuing peptide libraries with drug-likeness36
Structural basis of AcrIF24 as an anti-CRISPR protein and transcriptional suppressor36
A modification-centric assessment tool for the performance of chemoproteomic probes36
A PASS for protein secretion36
Molecular basis for ubiquitin/Fubi cross-reactivity in USP16 and USP3635
A topological switch in CFTR modulates channel activity and sensitivity to unfolding35
Structural basis of TRPV3 inhibition by an antagonist35
Thoughts for the future35
Structural mechanisms of TRPV2 modulation by endogenous and exogenous ligands35
Rapid discovery of cyclic peptide protein aggregation inhibitors by continuous selection35
Structural basis for inhibition of the drug efflux pump NorA from Staphylococcus aureus34
The realization of CRISPR gene therapy34
Spontaneously established syntrophic yeast communities improve bioproduction34
Mechanism of nucleosomal H2A K13/15 monoubiquitination and adjacent dual monoubiquitination by RNF16834
An allosteric redox switch involved in oxygen protection in a CO2 reductase34
CRISPR–Cas12a-mediated DNA clamping triggers target-strand cleavage34
Dissolution of oncofusion transcription factor condensates for cancer therapy33
Publisher Correction: Polyvalent folate receptor-targeting chimeras for degradation of membrane proteins33
Hippo pathway regulation by phosphatidylinositol transfer protein and phosphoinositides33
Chemical Decoding of Spatial Biology33
Forced rewiring of RTK signaling33
Convergent evolution of bacterial ceramide synthesis33
Redefining the off switch32
Shackled ribosomes unleashed32
Genetically engineered synthetic cells activate cargo release upon temperature shift32
Cross-kingdom warfare32
Click, release, destroy32
Sialic acid-containing glycolipids mediate binding and viral entry of SARS-CoV-232
Evading resistance at the double31
Basket of sweets31
Engineered bacterial swarm patterns as spatial records of environmental inputs31
A new class of macrocyclic peptides31
Moonlighting in the membrane31
Author Correction: Combining CRISPRi and metabolomics for functional annotation of compound libraries31
Bringing chemistry to medicine to redefine the undruggable31
An alternative mechanism for recruiting Cas2/3 in a phage-encoded CRISPR–Cas system30
Author Correction: A cell-free biosensor signal amplification circuit with polymerase strand recycling30
TMEM164 is an acyltransferase that forms ferroptotic C20:4 ether phospholipids30
Engineering from evolution30
Selective targeting of oncogenic hotspot mutations of the HER2 extracellular domain30
Studying ATP synthesis in situ30
Receptors from an ADAR trick30
Shifting redox reaction equilibria on demand using an orthogonal redox cofactor30
Enzymatic synthesis of peptide therapeutics29
Drug addiction unveils a repressive methylation ceiling in EZH2-mutant lymphoma29
Programming biological communication between distinct membraneless compartments29
A single sensor controls large variations in zinc quotas in a marine cyanobacterium29
Unbalanced response to growth variations reshapes the cell fate decision landscape29
Chemical editing of proteoglycan architecture29
Click biology highlights the opportunities from reliable biological reactions29
Dynamic eIF3a O-GlcNAcylation controls translation reinitiation during nutrient stress29
Structural basis of a small monomeric Clivia fluorogenic RNA with a large Stokes shift29
Ligand recognition and G-protein coupling selectivity of cholecystokinin A receptor29
Small-molecule inhibition of the archetypal UbiB protein COQ829
Context-based sensing of orthosomycin antibiotics by the translating ribosome28
Recording calcium concentrations28
Aiming for the pocket28
Cutting the tail28
Catalysis under stress28
Building light-activated synthetic cells that induce gene expression in bacteria via quorum sensing28
State of play28
De novo development of small cyclic peptides that are orally bioavailable28
In search of chemical rationales28
Traffic control28
Programmable solid-state condensates for spatiotemporal control of mammalian gene expression27
Design principles imprinted by evolution27
The protein universe in 3D27
In silico prohormone processing27
Learning from CoQ10 history27
Partitioning of a 2-bit hash function across 66 communicating cells27
Identifying p53-independent apoptosis27
Combining CRISPRi and metabolomics for functional annotation of compound libraries26
Capturing copper to inhibit inflammation26
Antibodies expand the scope of angiotensin receptor pharmacology26
Discovery and biosynthesis of cyclic plant peptides via autocatalytic cyclases26
Cryptic enzymatic assembly of peptides armed with β-lactone warheads26
A new RNA performs old chemistry25
Proximity-inducing pharmacology25
Depletion of creatine phosphagen energetics with a covalent creatine kinase inhibitor25
Put another ring on it25
Expanding the molecular grammar of polar residues and arginine in FUS phase separation25
Insights into G-protein coupling preference from cryo-EM structures of Gq-bound PTH1R25
Velcrin-induced selective cleavage of tRNALeu(TAA) by SLFN12 causes cancer cell death25
RAS signaling gets granular25
Long-term super-resolution inner mitochondrial membrane imaging with a lipid probe25
Artificial intelligence uncovers carcinogenic human metabolites25
PRMT inhibition induces a viral mimicry response in triple-negative breast cancer25
Amyloid conformation-dependent disaggregation in a reconstituted yeast prion system24
A new twist to increase ion flow24
Molecular conversations24
It’s in the blood24
Drivers of intrinsic resistance24
A gut feeling24
A complex struggle for direction24
Brassinosteroids en route24
Stress it up24
Galectin-13 reduces membrane localization of SLC7A11 for ferroptosis propagation23
Chemical screening by time-resolved X-ray scattering to discover allosteric probes23
Auto-inhibition and activation of a short Argonaute-associated TIR-APAZ defense system23
Molecular glue modulates mitochondria23
The chemical language of protein glycation23
Transcriptional regulation of living materials via extracellular electron transfer23
One-carbon footprint in B cells23
Protein-based bandpass filters for controlling cellular signaling with chemical inputs23
How nature ties peptide knots23
Old path, new frontier22
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