Nature Chemical Biology

Article	Citations
Plasma membranes are asymmetric in lipid unsaturation, packing and protein shape	419
Metabolic determinants of cancer cell sensitivity to canonical ferroptosis inducers	361
TRUPATH, an open-source biosensor platform for interrogating the GPCR transducerome	296
LYTACs that engage the asialoglycoprotein receptor for targeted protein degradation	225
SARS-CoV-2 Mpro inhibitors and activity-based probes for patient-sample imaging	213
Rational discovery of molecular glue degraders via scalable chemical profiling	205
Targeted glycan degradation potentiates the anticancer immune response in vivo	204
m6A-binding YTHDF proteins promote stress granule formation	191
Phospholipase iPLA2β averts ferroptosis by eliminating a redox lipid death signal	181
Mechanistic dissection of increased enzymatic rate in a phase-separated compartment	158
In vitro prototyping and rapid optimization of biosynthetic enzymes for cell design	141
Sialic acid-containing glycolipids mediate binding and viral entry of SARS-CoV-2	135
Structure- and mechanism-guided design of single fluorescent protein-based biosensors	135
Deubiquitinase-targeting chimeras for targeted protein stabilization	132
Structural and mechanistic insights into 5-lipoxygenase inhibition by natural products	130
Structural and functional consequences of reversible lipid asymmetry in living membranes	129
Programmed genome editing by a miniature CRISPR-Cas12f nuclease	128
Accelerated RNA detection using tandem CRISPR nucleases	127
Electric field stimulates production of highly conductive microbial OmcZ nanowires	121
Trivalent PROTACs enhance protein degradation via combined avidity and cooperativity	114
Controlling and enhancing CRISPR systems	110
Hydrogel-based biocontainment of bacteria for continuous sensing and computation	108
Formation and functionalization of membraneless compartments in Escherichia coli	101
A small molecule G6PD inhibitor reveals immune dependence on pentose phosphate pathway	100
Acoustic biosensors for ultrasound imaging of enzyme activity	93

Pyruvate-responsive genetic circuits for dynamic control of central metabolism	93
ROS regulated reversible protein phase separation synchronizes plant flowering	92
Pharmacologic IRE1/XBP1s activation confers targeted ER proteostasis reprogramming	91
Bifunctional small molecules that mediate the degradation of extracellular proteins	91
Cholesterol access in cellular membranes controls Hedgehog signaling	91
The HaloTag as a general scaffold for far-red tunable chemigenetic indicators	88
Structure and activity of human TMPRSS2 protease implicated in SARS-CoV-2 activation	88
Living materials fabricated via gradient mineralization of light-inducible biofilms	87
Single-molecule analysis reveals agonist-specific dimer formation of µ-opioid receptors	87
Manumycin polyketides act as molecular glues between UBR7 and P53	84
Metabolic engineering strategies to enable microbial utilization of C1 feedstocks	83
Functional characterization of a PROTAC directed against BRAF mutant V600E	83
Sulfopin is a covalent inhibitor of Pin1 that blocks Myc-driven tumors in vivo	82
Hydropersulfides inhibit lipid peroxidation and ferroptosis by scavenging radicals	82
A community resource for paired genomic and metabolomic data mining	80
The developing toolkit of continuous directed evolution	80
Bariatric surgery reveals a gut-restricted TGR5 agonist with anti-diabetic effects	80
A compendium of kinetic modulatory profiles identifies ferroptosis regulators	79
Optogenetic control of the lac operon for bacterial chemical and protein production	78
Rerouting plant terpene biosynthesis enables momilactone pathway elucidation	77
Peroxisome compartmentalization of a toxic enzyme improves alkaloid production	77
Bi-paratopic and multivalent VH domains block ACE2 binding and neutralize SARS-CoV-2	76
Discovery of a first-in-class CDK2 selective degrader for AML differentiation therapy	76
Structural basis for diamide modulation of ryanodine receptor	75
PROTAC-mediated degradation reveals a non-catalytic function of AURORA-A kinase	74
NADP modulates RNA m6A methylation and adipogenesis via enhancing FTO activity	72
Engineering cofactor supply and recycling to drive phenolic acid biosynthesis in yeast	72
Discovery and resistance mechanism of a selective CDK12 degrader	72
Chemically informed analyses of metabolomics mass spectrometry data with Qemistree	71
Cell type-selective secretome profiling in vivo	71
Structure of Erm-modified 70S ribosome reveals the mechanism of macrolide resistance	70
Identification of essential sites of lipid peroxidation in ferroptosis	70
YY1 interacts with guanine quadruplexes to regulate DNA looping and gene expression	70
Defining new chemical space for drug penetration into Gram-negative bacteria	68
Designer protein assemblies with tunable phase diagrams in living cells	68
Water-processable, biodegradable and coatable aquaplastic from engineered biofilms	66
Hierarchical chemical determination of amyloid polymorphs in neurodegenerative disease	65
Plant terpenoid metabolism co-opts a component of the cell wall biosynthesis machinery	65
Deep learning-guided discovery of an antibiotic targeting Acinetobacter baumannii	64
Engineered ACE2 decoy mitigates lung injury and death induced by SARS-CoV-2 variants	63
Designer membraneless organelles sequester native factors for control of cell behavior	63
NMR and EPR reveal a compaction of the RNA-binding protein FUS upon droplet formation	63
Phase separation of RNA-binding protein promotes polymerase binding and transcription	62
Strategies for monitoring cell–cell interactions	62
Bottom-up de novo design of functional proteins with complex structural features	62
Snapshots and ensembles of BTK and cIAP1 protein degrader ternary complexes	62
Target protein deglycosylation in living cells by a nanobody-fused split O-GlcNAcase	62
Organelle membrane-specific chemical labeling and dynamic imaging in living cells	61
Engineering a precise adenine base editor with minimal bystander editing	61
Structural insights into probe-dependent positive allosterism of the GLP-1 receptor	61

Increasing the efficiency and precision of prime editing with guide RNA pairs	61
Learning the chemical grammar of biomolecular condensates	60
Adaptive mechanisms of plant specialized metabolism connecting chemistry to function	60
Programming cell-free biosensors with DNA strand displacement circuits	59
VCP/p97 regulates Beclin-1-dependent autophagy initiation	59
An ultrasensitive biosensor for high-resolution kinase activity imaging in awake mice	58
RNA structure probing uncovers RNA structure-dependent biological functions	58
Sterols in an intramolecular channel of Smoothened mediate Hedgehog signaling	57
Dissecting the Pol II transcription cycle and derailing cancer with CDK inhibitors	57
Ligand recognition and G-protein coupling selectivity of cholecystokinin A receptor	57
Small molecule probes for targeting autophagy	56
Chemical acylation of an acquired serine suppresses oncogenic signaling of K-Ras(G12S)	56
Acute pharmacological degradation of Helios destabilizes regulatory T cells	56
Rapid generation of potent antibodies by autonomous hypermutation in yeast	56
Biomolecular condensates amplify mRNA decapping by biasing enzyme conformation	55
Design of orthogonal regulatory systems for modulating gene expression in plants	55
Lipid metabolism in T cell signaling and function	55
Comparative tRNA sequencing and RNA mass spectrometry for surveying tRNA modifications	55
An allosteric modulator binds to a conformational hub in the β2 adrenergic receptor	54
Circularly permuted LOV2 as a modular photoswitch for optogenetic engineering	54
KRAS is vulnerable to reversible switch-II pocket engagement in cells	53
Discovery of a NAPE-PLD inhibitor that modulates emotional behavior in mice	53
PGE1 and PGA1 bind to Nurr1 and activate its transcriptional function	52
ABHD17 regulation of plasma membrane palmitoylation and N-Ras-dependent cancer growth	52
Covalent inhibition of NSD1 histone methyltransferase	52
Structural dissimilarity from self drives neoepitope escape from immune tolerance	52
Ribosome stalling during selenoprotein translation exposes a ferroptosis vulnerability	52
Chromatin as a key consumer in the metabolite economy	52
Robust direct digital-to-biological data storage in living cells	52
ARID2 is a pomalidomide-dependent CRL4CRBN substrate in multiple myeloma cells	52
Cuticle thickness affects dynamics of volatile emission from petunia flowers	50
Oncohistone mutations enhance chromatin remodeling and alter cell fates	50
Computation-guided optimization of split protein systems	50
Targeting androgen receptor phase separation to overcome antiandrogen resistance	49
The evolution of synthetic receptor systems	48
PRMT inhibition induces a viral mimicry response in triple-negative breast cancer	47
Orthogonal fluorescent chemogenetic reporters for multicolor imaging	47
Structural basis for RING-Cys-Relay E3 ligase activity and its role in axon integrity	46
A brief guideline for studies of phase-separated biomolecular condensates	45
Characterization of a patient-derived variant of GPX4 for precision therapy	45
Chemical strategies to overcome resistance against targeted anticancer therapeutics	44
Conformational rearrangement during activation of a metabotropic glutamate receptor	44
Selective N-glycan editing on living cell surfaces to probe glycoconjugate function	44
Chains of evidence from correlations to causal molecules in microbiome-linked diseases	44
K29-linked ubiquitin signaling regulates proteotoxic stress response and cell cycle	43
Lineage tracing and analog recording in mammalian cells by single-site DNA writing	43
G12/13 is activated by acute tethered agonist exposure in the adhesion GPCR ADGRL3	43
Systematic discovery of biomolecular condensate-specific protein phosphorylation	43
Ancient plant-like terpene biosynthesis in corals	43
Structural basis of sphingosine-1-phosphate receptor 1 activation and biased agonism	43
Dynamics of an LPS translocon induced by substrate and an antimicrobial peptide	43
Artificial intelligence foundation for therapeutic science	43
Structural basis for selectivity in a highly reducing type II polyketide synthase	42
Ion channels as lipid sensors: from structures to mechanisms	42
Molecular mechanism of allosteric modulation for the cannabinoid receptor CB1	42
Selective G protein signaling driven by substance P–neurokinin receptor dynamics	42
Identification of a potent and selective covalent Pin1 inhibitor	42
Tetracenomycin X inhibits translation by binding within the ribosomal exit tunnel	42
Structural basis for non-radical catalysis by TsrM, a radical SAM methylase	42
Insights into distinct signaling profiles of the µOR activated by diverse agonists	42
H2B Lys34 Ubiquitination Induces Nucleosome Distortion to Stimulate Dot1L Activity	42
Engineering AraC to make it responsive to light instead of arabinose	41
A chemical probe targeting the PWWP domain alters NSD2 nucleolar localization	41
Detection of cell–cell interactions via photocatalytic cell tagging	41
Repurposing an adenine riboswitch into a fluorogenic imaging and sensing tag	41
Prospecting for molecular glues	41
Programmable living assembly of materials by bacterial adhesion	41
Engineering CAR-T cells to activate small-molecule drugs in situ	40
Visualizing a protonated RNA state that modulates microRNA-21 maturation	40
Reversible lysine-targeted probes reveal residence time-based kinase selectivity	40
Using fungible biosensors to evolve improved alkaloid biosyntheses	39
Reversal of nucleobase methylation by dioxygenases	39
Why succinate? Physiological regulation by a mitochondrial coenzyme Q sentinel	39
Modeling the expansion of virtual screening libraries	39
CueR activates transcription through a DNA distortion mechanism	38
Widespread occurrence of covalent lysine–cysteine redox switches in proteins	38
Laboratory evolution of a sortase enzyme that modifies amyloid-β protein	38
Characterizing the portability of phage-encoded homologous recombination proteins	38
Discovery and biosynthesis of cyclic plant peptides via autocatalytic cyclases	38
Membrane phase separation drives responsive assembly of receptor signaling domains	37

Identification and mechanism of G protein-biased ligands for chemokine receptor CCR1	37
Allosteric interactions in the parathyroid hormone GPCR–arrestin complex formation	37
Selective inhibitors of JAK1 targeting an isoform-restricted allosteric cysteine	37
Target deconvolution of HDAC pharmacopoeia reveals MBLAC2 as common off-target	37
Activity-based RNA-modifying enzyme probing reveals DUS3L-mediated dihydrouridylation	36
A bioluminescent probe for longitudinal monitoring of mitochondrial membrane potential	36
Spectroscopic coherent Raman imaging of Caenorhabditis elegans reveals lipid particle diversity	36
Targeted degradation via direct 26S proteasome recruitment	36
Functional E3 ligase hotspots and resistance mechanisms to small-molecule degraders	36
Convergent evolution of bacterial ceramide synthesis	36
Functional spectrum and specificity of mitochondrial ferredoxins FDX1 and FDX2	36
Ancient defensive terpene biosynthetic gene clusters in the soft corals	35
A bio-inspired cell-free system for cannabinoid production from inexpensive inputs	35
A nucleotide-switch mechanism mediates opposing catalytic activities of Rel enzymes	35
Production of Tyrian purple indigoid dye from tryptophan in Escherichia coli	35
Molecular basis for arginine C-terminal degron recognition by Cul2FEM1 E3 ligase	35
Palmitoylated acyl protein thioesterase APT2 deforms membranes to extract substrate acyl chains	35
A new dawn beyond lysine ubiquitination	35
Synthetic protein condensates for cellular and metabolic engineering	35
Biosynthesis of triacsin featuring an N-hydroxytriazene pharmacophore	34
Structural insight into the formation of lipoprotein-β-barrel complexes	34
Programmable synthetic biomolecular condensates for cellular control	34
YAP-dependent proliferation by a small molecule targeting annexin A2	34
Small-molecule inhibitors targeting Polycomb repressive complex 1 RING domain	34
The conformational cycle of a prototypical voltage-gated sodium channel	33
Genetically encoded multivalent liquid glycan array displayed on M13 bacteriophage	33
Molecular and environmental determinants of biomolecular condensate formation	33
Engineered LwaCas13a with enhanced collateral activity for nucleic acid detection	33
Condensation of SEUSS promotes hyperosmotic stress tolerance in Arabidopsis	33
Controllable genome editing with split-engineered base editors	33
Discovery of small-molecule enzyme activators by activity-based protein profiling	32
Use of paramagnetic 19F NMR to monitor domain movement in a glutamate transporter homolog	32
Structure-based investigation of fluorogenic Pepper aptamer	32
Glucosylation prevents plant defense activation in phloem-feeding insects	32
Permissive epigenomes endow reprogramming competence to transcriptional regulators	32
Cryo-EM structure of the RNA-guided ribonuclease Cas12g	32
Combining CRISPRi and metabolomics for functional annotation of compound libraries	32
A proteome-wide map of 20(S)-hydroxycholesterol interactors in cell membranes	32
CUL5-ARIH2 E3-E3 ubiquitin ligase structure reveals cullin-specific NEDD8 activation	32
Bright and stable luminescent probes for target engagement profiling in live cells	32
Selective inhibitors of mTORC1 activate 4EBP1 and suppress tumor growth	31
Dynamic crotonylation of EB1 by TIP60 ensures accurate spindle positioning in mitosis	31
A mass spectrometry-based proteome map of drug action in lung cancer cell lines	31
O-GlcNAcylation promotes pancreatic tumor growth by regulating malate dehydrogenase 1	31
Identifying cell receptors for the nanoparticle protein corona using genome screens	31
Microtubule lattice spacing governs cohesive envelope formation of tau family proteins	31
Imaging and targeting LOX-mediated tissue remodeling with a reactive collagen peptide	31
Prospecting for natural products by genome mining and microcrystal electron diffraction	31
Engineering orthogonal human O-linked glycoprotein biosynthesis in bacteria	30
p63 uses a switch-like mechanism to set the threshold for induction of apoptosis	30
Precise genome editing across kingdoms of life using retron-derived DNA	30
Reaction pathway engineering converts a radical hydroxylase into a halogenase	29
Site-specific ubiquitination affects protein energetics and proteasomal degradation	29
Active turnover of genomic methylcytosine in pluripotent cells	29
Spatial decoding of endosomal cAMP signals by a metastable cytoplasmic PKA network	29
Enzymatic C–H activation of aromatic compounds through CO2 fixation	29
Mechanical strength of RNA knot in Zika virus protects against cellular defenses	29
Tools, tactics and objectives to interrogate cellular roles of O-GlcNAc in disease	29
Quantitative profiling of pseudouridylation landscape in the human transcriptome	28
Structures of the human cholecystokinin receptors bound to agonists and antagonists	28
Mucin O-glycans are natural inhibitors of Candida albicans pathogenicity	28
Mutanofactin promotes adhesion and biofilm formation of cariogenic Streptococcus mutans	27
Modulation of microbial community dynamics by spatial partitioning	27
HUWE1 employs a giant substrate-binding ring to feed and regulate its HECT E3 domain	27
A quantitative method for proteome reallocation using minimal regulatory interventions	27
Single-cell multi-omics in the medicinal plant Catharanthus roseus	27
Molecular basis for ubiquitin ligase CRL2FEM1C-mediated recognition of C-degron	26
Cas13d knockdown of lung protease Ctsl prevents and treats SARS-CoV-2 infection	26
CRISPR–dCas12a-mediated genetic circuit cascades for multiplexed pathway optimization	26
Genome mining for unknown–unknown natural products	26
A roadmap to creating ferroptosis-based medicines	26
Structural basis for persulfide-sensing specificity in a transcriptional regulator	26
Hovlinc is a recently evolved class of ribozyme found in human lncRNA	26
Peroxisomal-derived ether phospholipids link nucleotides to respirasome assembly	26
Structural and functional diversity among agonist-bound states of the GLP-1 receptor	25
The importance of the membrane for biophysical measurements	25
An optimized bioluminescent substrate for non-invasive imaging in the brain	25
Linkage-specific ubiquitin chain formation depends on a lysine hydrocarbon ruler	25
Engineering site-selective incorporation of fluorine into polyketides	25
Harnessing nanotechnology to expand the toolbox of chemical biology	25
Host and microbiota metabolic signals in aging and longevity	25
Structures and function of the amino acid polymerase cyanophycin synthetase	25
Peroxiredoxins couple metabolism and cell division in an ultradian cycle	24
Organoid screening reveals epigenetic vulnerabilities in human colorectal cancer	24
Temperature-responsive optogenetic probes of cell signaling	24
Multiplexed GTPase and GEF biosensor imaging enables network connectivity analysis	24
Pyridoxal-5′-phosphate-dependent alkyl transfer in nucleoside antibiotic biosynthesis	24
Selective regulation of human TRAAK channels by biologically active phospholipids	23
Structural basis for inhibition of the drug efflux pump NorA from Staphylococcus aureus	23
Sulfated glycans engage the Ang–Tie pathway to regulate vascular development	22
A general strategy to red-shift green fluorescent protein-based biosensors	22
Interhelical interactions within the STIM1 CC1 domain modulate CRAC channel activation	22
Biosynthesis of saponin defensive compounds in sea cucumbers	21
A structural basis for prion strain diversity	21
Stepwise membrane binding of extended synaptotagmins revealed by optical tweezers	21