Nature Chemical Biology

Article	Citations
Making a 6mA demethylase	219
Chemical targeting of amyloids	218
To TnpB or not TnpB? Cas12 is the answer	193
Detecting features of antibody structure through their mediator-accessible redox activities	187
Channeling kynurenine	187
A sulfate amuse-bouche	181
Cyclic signature	179
Surviving salt stress	160
Development of cyclic peptides that can be administered orally to inhibit disease targets	156
A vicious cycle	155
Flipping the polarity switch	151
Sterol homeostasis in yeast	146
Altering the cap	143
Sensing the air	122
Seeing the retention	117
Publisher Correction: Accelerated RNA detection using tandem CRISPR nucleases	114
Assembly-activated aggregation	114
Facile generation of drug-like conformational antibodies specific for amyloid fibrils	107
Artificial intelligence foundation for therapeutic science	105
Bacteria lose a pep in their step	105
An engineered trafficking biosensor reveals a role for DNAJC13 in DOR downregulation	104
Determining the role of peroxidation of subcellular lipid membranes in ferroptosis	104
Author Correction: ML-enhanced peroxisome capacity enables compartmentalization of multienzyme pathway	103
Lysosome-targeting chimeras evolve	102
Engineering eukaryotic transposon-encoded Fanzor2 system for genome editing in mammals	100

Inter-kingdom electromechanical communication	94
Chemical genomics with pyrvinium identifies C1orf115 as a regulator of drug efflux	93
A pseudoenzyme enables indole biosynthesis in eudicot plants	92
Ubiquitin-specific proximity labeling for the identification of E3 ligase substrates	89
Characterization of a patient-derived variant of GPX4 for precision therapy	87
E2–Ub-R74G strategy reveals E2-specific ubiquitin conjugation profiles in live cells	87
Rationally seeded computational protein design of ɑ-helical barrels	86
Programmable living assembly of materials by bacterial adhesion	85
The landscape of targets and lead molecules for remyelination	85
Lysine l-lactylation is the dominant lactylation isomer induced by glycolysis	83
Calcium-gated potassium channel blockade via membrane-facing fenestrations	83
Ribosome stalling during selenoprotein translation exposes a ferroptosis vulnerability	82
Small-molecule dissolution of stress granules by redox modulation benefits ALS models	80
A class of anti-inflammatory lipids decrease with aging in the central nervous system	79
Chemigenetic indicators based on synthetic chelators and green fluorescent protein	78
Macrolones target bacterial ribosomes and DNA gyrase and can evade resistance mechanisms	78
Seismic shift	78
Small-molecule trapping of an RNA-binding protein blocks cancer cell growth	77
The core of the matter	76
Controlling sulfation	76
Running through the blocks	75
Brake disposal	75
Peptides hit the catalysis walk	72
Badminton at nanoscale	72
Functional profiling of serine, threonine and tyrosine sites	72
Making transient complexes stick	71
Tuned out	71
A high-throughput screening platform for enzymes active on mucin-type O-glycoproteins	70
Discovery and molecular basis of subtype-selective cyclophilin inhibitors	70
Visualizing drug effects over time in live animals using optical pharmacodynamics	70
A wrench in the motor	70
Autoinducer-fluorophore conjugates enable FRET in LuxR proteins in vitro and in cells	68
Open-ended molecular recording of sequential cellular events into DNA	67
M24B aminopeptidase inhibitors selectively activate the CARD8 inflammasome	67
Development of an allosteric adhesion GPCR nanobody with therapeutic potential	66
Endogenous currents in HEK 293 cells are inhibited by memantine	64
Small molecule targeting of chromatin writers in cancer	63
Etoposide promotes DNA loop trapping and barrier formation by topoisomerase II	62
Engineering CAR-T cells to activate small-molecule drugs in situ	62
Programmed RNA editing with an evolved bacterial adenosine deaminase	62
Small molecule inhibits KCNQ channels with a non-blocking mechanism	62
Structure-based investigation of fluorogenic Pepper aptamer	62
Site-specific encoding of photoactivity and photoreactivity into antibody fragments	61
An optimized bioluminescent substrate for non-invasive imaging in the brain	60
Escherichia coli small molecule metabolism at the host–microorganism interface	60
Survival of the sweetest tooth	58
Medicine from modified mRNA	58
Degrade the RNA	58
Molecular basis of β-arrestin coupling to the metabotropic glutamate receptor mGlu3	57
Superbugs leave fingerprints	57

Affinity for both sides	56
Stepwise membrane binding of extended synaptotagmins revealed by optical tweezers	56
NO signal	55
Direct methylation sequencing	55
Single-cell sensor analyses reveal signaling programs enabling Ras-G12C drug resistance	55
Lighting up kinase contacts in situ	55
RNA-based programmable DNA cleavage	55
Waking sleeping viruses	55
Programmable RNA base editing via targeted modifications	55
Rolling the RBP snowballs	55
Synthesizing cellular LOGIC	55
A home for orphans	55
All that glows is gold	54
The right angle	54
Structure and mechanism of a neuropeptide-activated channel in the ENaC/DEG superfamily	53
Pharmacological targeting of BMAL1 modulates circadian and immune pathways	53
ML-enhanced peroxisome capacity enables compartmentalization of multienzyme pathway	52
Functional targeting of membrane transporters and enzymes to peroxisomes	52
Engineering APOBEC3A deaminase for highly accurate and efficient base editing	51
Direct mapping of tyrosine sulfation states in native peptides by nanopore	51
Engineering a xylose fermenting yeast for lignocellulosic ethanol production	51
Hydroxytryptophan biosynthesis by a family of heme-dependent enzymes in bacteria	50
Selective bioorthogonal probe for N-glycan hybrid structures	50
Condensation of SEUSS promotes hyperosmotic stress tolerance in Arabidopsis	49
Structural basis of efficacy-driven ligand selectivity at GPCRs	49
Mucin O-glycans are natural inhibitors of Candida albicans pathogenicity	48
Cas13d knockdown of lung protease Ctsl prevents and treats SARS-CoV-2 infection	48
Deep learning-guided discovery of an antibiotic targeting Acinetobacter baumannii	48
Providing inclusivity	47
Switching off the stress response	47
Catch in nucleus	46
Sweet synthetic chaperones	46
Prospering phase separation	45
Author Correction: Phage-assisted evolution of compact Cas9 variants targeting a simple NNG PAM	45
A peptide dehydratase with core strength	45
Chemical-based epigenetic reprogramming to advance pluripotency and totipotency	44
Illuminating GPCR trafficking	44
Dissociation for living	44
A single-component, light-assisted uncaging switch for endoproteolytic release	44
A fat-fueled fatality	44
In-cell kinetic stability is an essential trait in metallo-β-lactamase evolution	43
A dimeric proteomimetic prevents SARS-CoV-2 infection by dimerizing the spike protein	43
Boric acid intercepts 80S ribosome migration from AUG-stop by stabilizing eRF1	43
Chemically inducible split protein regulators for mammalian cells	43
Inhibition of translation termination by the antimicrobial peptide Drosocin	43
The β-subunit of tryptophan synthase is a latent tyrosine synthase	41
Chemically engineered antibodies for autophagy-based receptor degradation	41
Modulation of microbial community dynamics by spatial partitioning	40
Genome mining for unknown–unknown natural products	40
Dynamic basis for dA•dGTP and dA•d8OGTP misincorporation via Hoogsteen base pairs	40
Anti-infective bile acids bind and inactivate a Salmonella virulence regulator	40
Phase in phase	39
ENO1 promotes liver carcinogenesis through YAP1-dependent arachidonic acid metabolism	39
Signal peptide mimicry primes Sec61 for client-selective inhibition	39
CUL5-ARIH2 E3-E3 ubiquitin ligase structure reveals cullin-specific NEDD8 activation	39
Structural snapshots along K48-linked ubiquitin chain formation by the HECT E3 UBR5	39
A CRISPR activation screen identifies FBXO22 supporting targeted protein degradation	39
Deep dive into a drug pump	38
Enzyme assemblies on demand	38
Nanopore glycan profiling	38
Size matters	38
Alzheimer’s disease–implicated protein tau puts the squeeze on microtubules	38
A rapid chemical reprogramming system to generate human pluripotent stem cells	38
Capturing receptor states with glue	38
Disarming the pathogen	38
Lighting up DNA	37
Expanding beyond the capability of nature	37
Under pressure	37
Author Correction: An engineered hypercompact CRISPR-Cas12f system with boosted gene-editing activity	37
Imbuing peptide libraries with drug-likeness	36
Structural basis of AcrIF24 as an anti-CRISPR protein and transcriptional suppressor	36
A modification-centric assessment tool for the performance of chemoproteomic probes	36
A PASS for protein secretion	36
Molecular basis for ubiquitin/Fubi cross-reactivity in USP16 and USP36	35
A topological switch in CFTR modulates channel activity and sensitivity to unfolding	35
Structural basis of TRPV3 inhibition by an antagonist	35
Thoughts for the future	35
Structural mechanisms of TRPV2 modulation by endogenous and exogenous ligands	35
Rapid discovery of cyclic peptide protein aggregation inhibitors by continuous selection	35
Structural basis for inhibition of the drug efflux pump NorA from Staphylococcus aureus	34

The realization of CRISPR gene therapy	34
Spontaneously established syntrophic yeast communities improve bioproduction	34
Mechanism of nucleosomal H2A K13/15 monoubiquitination and adjacent dual monoubiquitination by RNF168	34
An allosteric redox switch involved in oxygen protection in a CO2 reductase	34
CRISPR–Cas12a-mediated DNA clamping triggers target-strand cleavage	34
Dissolution of oncofusion transcription factor condensates for cancer therapy	33
Publisher Correction: Polyvalent folate receptor-targeting chimeras for degradation of membrane proteins	33
Hippo pathway regulation by phosphatidylinositol transfer protein and phosphoinositides	33
Chemical Decoding of Spatial Biology	33
Forced rewiring of RTK signaling	33
Convergent evolution of bacterial ceramide synthesis	33
Redefining the off switch	32
Shackled ribosomes unleashed	32
Genetically engineered synthetic cells activate cargo release upon temperature shift	32
Cross-kingdom warfare	32
Click, release, destroy	32
Sialic acid-containing glycolipids mediate binding and viral entry of SARS-CoV-2	32
Evading resistance at the double	31
Basket of sweets	31
Engineered bacterial swarm patterns as spatial records of environmental inputs	31
A new class of macrocyclic peptides	31
Moonlighting in the membrane	31
Author Correction: Combining CRISPRi and metabolomics for functional annotation of compound libraries	31
Bringing chemistry to medicine to redefine the undruggable	31
An alternative mechanism for recruiting Cas2/3 in a phage-encoded CRISPR–Cas system	30
Author Correction: A cell-free biosensor signal amplification circuit with polymerase strand recycling	30
TMEM164 is an acyltransferase that forms ferroptotic C20:4 ether phospholipids	30
Engineering from evolution	30
Selective targeting of oncogenic hotspot mutations of the HER2 extracellular domain	30
Studying ATP synthesis in situ	30
Receptors from an ADAR trick	30
Shifting redox reaction equilibria on demand using an orthogonal redox cofactor	30
Enzymatic synthesis of peptide therapeutics	29
Drug addiction unveils a repressive methylation ceiling in EZH2-mutant lymphoma	29
Programming biological communication between distinct membraneless compartments	29
A single sensor controls large variations in zinc quotas in a marine cyanobacterium	29
Unbalanced response to growth variations reshapes the cell fate decision landscape	29
Chemical editing of proteoglycan architecture	29
Click biology highlights the opportunities from reliable biological reactions	29
Dynamic eIF3a O-GlcNAcylation controls translation reinitiation during nutrient stress	29
Structural basis of a small monomeric Clivia fluorogenic RNA with a large Stokes shift	29
Ligand recognition and G-protein coupling selectivity of cholecystokinin A receptor	29
Small-molecule inhibition of the archetypal UbiB protein COQ8	29
Context-based sensing of orthosomycin antibiotics by the translating ribosome	28
Recording calcium concentrations	28
Aiming for the pocket	28
Cutting the tail	28
Catalysis under stress	28
Building light-activated synthetic cells that induce gene expression in bacteria via quorum sensing	28
State of play	28
De novo development of small cyclic peptides that are orally bioavailable	28
In search of chemical rationales	28
Traffic control	28
Programmable solid-state condensates for spatiotemporal control of mammalian gene expression	27
Design principles imprinted by evolution	27
The protein universe in 3D	27
In silico prohormone processing	27
Learning from CoQ10 history	27
Partitioning of a 2-bit hash function across 66 communicating cells	27
Identifying p53-independent apoptosis	27
Combining CRISPRi and metabolomics for functional annotation of compound libraries	26
Capturing copper to inhibit inflammation	26
Antibodies expand the scope of angiotensin receptor pharmacology	26
Discovery and biosynthesis of cyclic plant peptides via autocatalytic cyclases	26
Cryptic enzymatic assembly of peptides armed with β-lactone warheads	26
A new RNA performs old chemistry	25
Proximity-inducing pharmacology	25
Depletion of creatine phosphagen energetics with a covalent creatine kinase inhibitor	25
Put another ring on it	25
Expanding the molecular grammar of polar residues and arginine in FUS phase separation	25
Insights into G-protein coupling preference from cryo-EM structures of Gq-bound PTH1R	25
Velcrin-induced selective cleavage of tRNALeu(TAA) by SLFN12 causes cancer cell death	25
RAS signaling gets granular	25
Long-term super-resolution inner mitochondrial membrane imaging with a lipid probe	25
Artificial intelligence uncovers carcinogenic human metabolites	25
PRMT inhibition induces a viral mimicry response in triple-negative breast cancer	25
Amyloid conformation-dependent disaggregation in a reconstituted yeast prion system	24
A new twist to increase ion flow	24
Molecular conversations	24
It’s in the blood	24
Drivers of intrinsic resistance	24
A gut feeling	24
A complex struggle for direction	24
Brassinosteroids en route	24
Stress it up	24
Galectin-13 reduces membrane localization of SLC7A11 for ferroptosis propagation	23
Chemical screening by time-resolved X-ray scattering to discover allosteric probes	23
Auto-inhibition and activation of a short Argonaute-associated TIR-APAZ defense system	23
Molecular glue modulates mitochondria	23
The chemical language of protein glycation	23
Transcriptional regulation of living materials via extracellular electron transfer	23
One-carbon footprint in B cells	23
Protein-based bandpass filters for controlling cellular signaling with chemical inputs	23
How nature ties peptide knots	23
Old path, new frontier	22