Nature Chemical Biology

Article	Citations
Flipping the polarity switch	274
Altering the cap	242
Sensing the air	206
Sterol homeostasis in yeast	202
A sulfate amuse-bouche	189
Cyclic signature	185
Surviving salt stress	169
Making a 6mA demethylase	169
Development of cyclic peptides that can be administered orally to inhibit disease targets	164
Chemical targeting of amyloids	139
To TnpB or not TnpB? Cas12 is the answer	134
Channeling kynurenine	132
A vicious cycle	127
Bacteria lose a pep in their step	118
Assembly-activated aggregation	117
Seeing the retention	113
Lysine l-lactylation is the dominant lactylation isomer induced by glycolysis	112
A pseudoenzyme enables indole biosynthesis in eudicot plants	112
Engineering eukaryotic transposon-encoded Fanzor2 system for genome editing in mammals	111
ALFA nanobody-guided endogenous labeling	110
The landscape of targets and lead molecules for remyelination	106
Inter-kingdom electromechanical communication	103
Calcium-gated potassium channel blockade via membrane-facing fenestrations	103
Detecting features of antibody structure through their mediator-accessible redox activities	100
E2–Ub-R74G strategy reveals E2-specific ubiquitin conjugation profiles in live cells	95

Rationally seeded computational protein design of ɑ-helical barrels	93
Ubiquitin-specific proximity labeling for the identification of E3 ligase substrates	92
Small-molecule dissolution of stress granules by redox modulation benefits ALS models	90
Artificial intelligence foundation for therapeutic science	90
Chemigenetic indicators based on synthetic chelators and green fluorescent protein	90
Macrolones target bacterial ribosomes and DNA gyrase and can evade resistance mechanisms	89
Publisher Correction: Accelerated RNA detection using tandem CRISPR nucleases	87
Determining the role of peroxidation of subcellular lipid membranes in ferroptosis	86
Programmable living assembly of materials by bacterial adhesion	86
An engineered trafficking biosensor reveals a role for DNAJC13 in DOR downregulation	84
Author Correction: ML-enhanced peroxisome capacity enables compartmentalization of multienzyme pathway	82
Facile generation of drug-like conformational antibodies specific for amyloid fibrils	81
A class of anti-inflammatory lipids decrease with aging in the central nervous system	81
Chemical genomics with pyrvinium identifies C1orf115 as a regulator of drug efflux	81
Ribosome stalling during selenoprotein translation exposes a ferroptosis vulnerability	81
Small-molecule trapping of an RNA-binding protein blocks cancer cell growth	80
Controlling sulfation	80
Characterization of a patient-derived variant of GPX4 for precision therapy	80
Seismic shift	80
Open-ended molecular recording of sequential cellular events into DNA	79
Endogenous currents in HEK 293 cells are inhibited by memantine	78
A wrench in the motor	78
Making transient complexes stick	78
Small molecule inhibits KCNQ channels with a non-blocking mechanism	77
SNAP-tag2 for faster and brighter protein labeling	76
Visualizing drug effects over time in live animals using optical pharmacodynamics	75
Functional profiling of serine, threonine and tyrosine sites	75
Oncometabolite 5-IP7 inhibits inositol 5-phosphatase to license E-cadherin endocytosis	75
Peptides hit the catalysis walk	73
Badminton at nanoscale	72
Tuned out	72
M24B aminopeptidase inhibitors selectively activate the CARD8 inflammasome	71
Autoinducer-fluorophore conjugates enable FRET in LuxR proteins in vitro and in cells	70
Running through the blocks	70
Brake disposal	70
Discovery and molecular basis of subtype-selective cyclophilin inhibitors	68
Programmed RNA editing with an evolved bacterial adenosine deaminase	67
A high-throughput screening platform for enzymes active on mucin-type O-glycoproteins	67
Small molecule targeting of chromatin writers in cancer	66
An optimized bioluminescent substrate for non-invasive imaging in the brain	66
Structure-based investigation of fluorogenic Pepper aptamer	66
Site-specific encoding of photoactivity and photoreactivity into antibody fragments	66
Development of an allosteric adhesion GPCR nanobody with therapeutic potential	66
Etoposide promotes DNA loop trapping and barrier formation by topoisomerase II	65
Affinity for both sides	64
Engineering CAR-T cells to activate small-molecule drugs in situ	64
Degrade the RNA	63
Superbugs leave fingerprints	63
Survival of the sweetest tooth	62
Medicine from modified mRNA	62

Direct methylation sequencing	61
Engineering APOBEC3A deaminase for highly accurate and efficient base editing	60
Protein evolution as a complex system	60
The right angle	59
An unbiased proteomic platform for ATE1-based arginylation profiling	59
Lighting up kinase contacts in situ	59
Waking sleeping viruses	59
Rolling the RBP snowballs	58
RNA-based programmable DNA cleavage	58
Synthesizing cellular LOGIC	58
NO signal	57
Stepwise membrane binding of extended synaptotagmins revealed by optical tweezers	57
All that glows is gold	57
A home for orphans	57
Engineering a xylose fermenting yeast for lignocellulosic ethanol production	55
Single-cell sensor analyses reveal signaling programs enabling Ras-G12C drug resistance	55
Pharmacological targeting of BMAL1 modulates circadian and immune pathways	55
Structure and mechanism of a neuropeptide-activated channel in the ENaC/DEG superfamily	55
Molecular basis of β-arrestin coupling to the metabotropic glutamate receptor mGlu3	55
Functional targeting of membrane transporters and enzymes to peroxisomes	53
ML-enhanced peroxisome capacity enables compartmentalization of multienzyme pathway	53
Programmable RNA base editing via targeted modifications	52
Hydroxytryptophan biosynthesis by a family of heme-dependent enzymes in bacteria	52
Mucin O-glycans are natural inhibitors of Candida albicans pathogenicity	51
Selective bioorthogonal probe for N-glycan hybrid structures	51
Deep learning-guided discovery of an antibiotic targeting Acinetobacter baumannii	51
Condensation of SEUSS promotes hyperosmotic stress tolerance in Arabidopsis	50
Structural basis of efficacy-driven ligand selectivity at GPCRs	50
Direct mapping of tyrosine sulfation states in native peptides by nanopore	49
Cas13d knockdown of lung protease Ctsl prevents and treats SARS-CoV-2 infection	49
Providing inclusivity	48
Catch in nucleus	48
Sweet synthetic chaperones	48
Switching off the stress response	48
ALDH2-mediated GABA biosynthesis regulates hippocampal LTP and learning adaptability	47
Prospering phase separation	46
Chemical-based epigenetic reprogramming to advance pluripotency and totipotency	46
Illuminating GPCR trafficking	46
Interactions with tau’s microtubule-binding repeats modulate amyloid-β aggregation and toxicity	46
A fat-fueled fatality	45
Dissociation for living	45
Chemically engineered antibodies for autophagy-based receptor degradation	45
A single-component, light-assisted uncaging switch for endoproteolytic release	44
Author Correction: Phage-assisted evolution of compact Cas9 variants targeting a simple NNG PAM	44
Boric acid intercepts 80S ribosome migration from AUG-stop by stabilizing eRF1	44
A rapid chemical reprogramming system to generate human pluripotent stem cells	44
Genome mining for unknown–unknown natural products	44
A peptide dehydratase with core strength	44
ENO1 promotes liver carcinogenesis through YAP1-dependent arachidonic acid metabolism	43
Modulation of microbial community dynamics by spatial partitioning	43
Phase in phase	43
Signal peptide mimicry primes Sec61 for client-selective inhibition	43
Dynamic basis for dA•dGTP and dA•d8OGTP misincorporation via Hoogsteen base pairs	43
Inhibition of translation termination by the antimicrobial peptide Drosocin	41
A CRISPR activation screen identifies FBXO22 supporting targeted protein degradation	40
In-cell kinetic stability is an essential trait in metallo-β-lactamase evolution	40
Site-selective protein editing by backbone extension acyl rearrangements	40
The β-subunit of tryptophan synthase is a latent tyrosine synthase	40
A dimeric proteomimetic prevents SARS-CoV-2 infection by dimerizing the spike protein	40
Structural snapshots along K48-linked ubiquitin chain formation by the HECT E3 UBR5	40
Chemically inducible split protein regulators for mammalian cells	40
Anti-infective bile acids bind and inactivate a Salmonella virulence regulator	40
Capturing receptor states with glue	39
Alzheimer’s disease–implicated protein tau puts the squeeze on microtubules	39
Author Correction: An engineered hypercompact CRISPR-Cas12f system with boosted gene-editing activity	39
Nanopore glycan profiling	39
Size matters	39
Enzyme assemblies on demand	39
Lighting up DNA	38
Chemical Decoding of Spatial Biology	38
Under pressure	38
Expanding beyond the capability of nature	38
Disarming the pathogen	38
Deep dive into a drug pump	38
Publisher Correction: Polyvalent folate receptor-targeting chimeras for degradation of membrane proteins	38
Spontaneously established syntrophic yeast communities improve bioproduction	37
Molecular basis for ubiquitin/Fubi cross-reactivity in USP16 and USP36	37
Structural basis of TRPV3 inhibition by an antagonist	37
Imbuing peptide libraries with drug-likeness	36
Hippo pathway regulation by phosphatidylinositol transfer protein and phosphoinositides	36

Thoughts for the future	36
Mechanism of nucleosomal H2A K13/15 monoubiquitination and adjacent dual monoubiquitination by RNF168	36
Structural basis of AcrIF24 as an anti-CRISPR protein and transcriptional suppressor	36
Rapid discovery of cyclic peptide protein aggregation inhibitors by continuous selection	36
An allosteric redox switch involved in oxygen protection in a CO2 reductase	36
A modification-centric assessment tool for the performance of chemoproteomic probes	35
Melting KRAS resistance	35
Dissolution of oncofusion transcription factor condensates for cancer therapy	35
The realization of CRISPR gene therapy	35
A PASS for protein secretion	35
Convergent evolution of bacterial ceramide synthesis	35
Forced rewiring of RTK signaling	35
Lipoyl deglutarylation by ABHD11 regulates mitochondrial and T cell metabolism	35
Structural basis for inhibition of the drug efflux pump NorA from Staphylococcus aureus	35
Shackled ribosomes unleashed	34
Redefining the off switch	34
Structural mechanisms of TRPV2 modulation by endogenous and exogenous ligands	34
CRISPR–Cas12a-mediated DNA clamping triggers target-strand cleavage	34
Cross-kingdom warfare	34
Genetically engineered synthetic cells activate cargo release upon temperature shift	34
Sialic acid-containing glycolipids mediate binding and viral entry of SARS-CoV-2	34
Click, release, destroy	34
Author Correction: Combining CRISPRi and metabolomics for functional annotation of compound libraries	33
Bringing chemistry to medicine to redefine the undruggable	33
Moonlighting in the membrane	33
Engineering from evolution	33
Basket of sweets	32
Studying ATP synthesis in situ	32
Evading resistance at the double	32
Engineered bacterial swarm patterns as spatial records of environmental inputs	32
An alternative mechanism for recruiting Cas2/3 in a phage-encoded CRISPR–Cas system	32
Unbalanced response to growth variations reshapes the cell fate decision landscape	31
A new class of macrocyclic peptides	31
Enhancing RNA base editing on mammalian transcripts with small nuclear RNAs	31
Chemical editing of proteoglycan architecture	30
Author Correction: A cell-free biosensor signal amplification circuit with polymerase strand recycling	30
A Ψ–Ψ codon–anticodon pairing in nonsense suppression and translational recoding	30
Enzymatic synthesis of peptide therapeutics	30
Structural basis of a small monomeric Clivia fluorogenic RNA with a large Stokes shift	30
Auxin branches out	30
A single sensor controls large variations in zinc quotas in a marine cyanobacterium	30
Programming biological communication between distinct membraneless compartments	29
Selective targeting of oncogenic hotspot mutations of the HER2 extracellular domain	29
Small-molecule inhibition of the archetypal UbiB protein COQ8	29
De novo development of small cyclic peptides that are orally bioavailable	29
Receptors from an ADAR trick	29
Drug addiction unveils a repressive methylation ceiling in EZH2-mutant lymphoma	29
Dynamic eIF3a O-GlcNAcylation controls translation reinitiation during nutrient stress	29
Click biology highlights the opportunities from reliable biological reactions	29
Shifting redox reaction equilibria on demand using an orthogonal redox cofactor	28
In search of chemical rationales	28
TMEM164 is an acyltransferase that forms ferroptotic C20:4 ether phospholipids	28
Cutting the tail	28
Building light-activated synthetic cells that induce gene expression in bacteria via quorum sensing	27
Aiming for the pocket	27
Insights into G-protein coupling preference from cryo-EM structures of Gq-bound PTH1R	27
State of play	27
Recording calcium concentrations	27
The protein universe in 3D	27
Traffic control	27
Context-based sensing of orthosomycin antibiotics by the translating ribosome	27
Catalysis under stress	27
Learning from CoQ10 history	26
GA-independent DELLA regulation by inositol pyrophosphate in a nonvascular land plant	26
Non-heme iron enzymes step into the spotlight	26
Depletion of creatine phosphagen energetics with a covalent creatine kinase inhibitor	26
In silico prohormone processing	26
Design principles imprinted by evolution	26
Cryptic enzymatic assembly of peptides armed with β-lactone warheads	26
Programmable solid-state condensates for spatiotemporal control of mammalian gene expression	26
Discovery and biosynthesis of cyclic plant peptides via autocatalytic cyclases	26
Mechanism of capsaicin entry into buried vanilloid sites in TRPV1	26
Proximity-inducing pharmacology	26
Expanding the molecular grammar of polar residues and arginine in FUS phase separation	25
Identifying p53-independent apoptosis	25
Partitioning of a 2-bit hash function across 66 communicating cells	25
Capturing copper to inhibit inflammation	25
Artificial intelligence uncovers carcinogenic human metabolites	25
PRMT inhibition induces a viral mimicry response in triple-negative breast cancer	25
Antibodies expand the scope of angiotensin receptor pharmacology	25
Long-term super-resolution inner mitochondrial membrane imaging with a lipid probe	25
Combining CRISPRi and metabolomics for functional annotation of compound libraries	25
Velcrin-induced selective cleavage of tRNALeu(TAA) by SLFN12 causes cancer cell death	25
It’s in the blood	24
One-carbon footprint in B cells	24
H2B Lys34 Ubiquitination Induces Nucleosome Distortion to Stimulate Dot1L Activity	24
Protein-based bandpass filters for controlling cellular signaling with chemical inputs	24
Auto-inhibition and activation of a short Argonaute-associated TIR-APAZ defense system	24
A complex struggle for direction	24
Small molecule agonist of mitochondrial fusion repairs mitochondrial dysfunction	24
Molecular glue modulates mitochondria	24
Stress it up	24
Transcriptional regulation of living materials via extracellular electron transfer	24
Brassinosteroids en route	24
The chemical language of protein glycation	24