OOIR: Observatory of International Research

Papers

(The TQCC of ACS Chemical Biology is 10. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-08-01 to 2025-08-01.)

Article	Citations
Simple Enzymatic Incorporation of 2′OMeU Nucleotide at the End of the Poly-A Tail for Enhancement of the mRNA Stability and Protein Expression	228
Introducing Our Authors	106
Introducing Our Authors	104
A Robust α-l-Fucosidase from Prevotella nigrescens for Glycoengineering Therapeutic Antibodies	94
Molecular Targeted Engagement of DPP9 in Rat Tissue Using CETSA, SP3 Processing, and Absolute Quantitation Mass Spectrometry	83
Visualization of Ectopic Serine Protease Activity by Förster Resonance Energy Transfer-Based Reporters	68
Antimicrobial Lasso Peptide Cloacaenodin Utilizes a Unique TonB-Dependent Transporter to Access Susceptible Bacteria	64
Correction to “Characterization of the Iron–Sulfur Cluster in the NCOA4 Fragment (383–522) and Its Interaction with Ferritin”	62
Spatiotemporal Proximity Labeling Tools to Track GlcNAc Sugar-Modified Functional Protein Hubs during Cellular Signaling	58
Multi-TACs: Targeting Solid Tumors with Multiple Immune Cell Co-engagers	57
Discovery of Small-Molecule Inhibitors of the PTK7/β-Catenin Interaction Targeting the Wnt Signaling Pathway in Colorectal Cancer	54
Ferroptosis Inhibitors Suppress Prostaglandin Synthesis in Lipopolysaccharide-Stimulated Macrophages	54
Targeting IRAK3 for Degradation to Enhance IL-12 Pro-inflammatory Cytokine Production	52
Structural and Biochemical Insights into Lignin-Oxidizing Activity of Bacterial Peroxidases against Soluble Substrates and Kraft Lignin	49
Target-Responsive DNA Hydrogels with Encapsulation and Release Properties Using Programmable CRISPR-Cas12a	49
In Situ Labeling of Pathogenic Tau Using Photo-Affinity Chemical Probes	47
Dynamic Regulation of 5-Formylcytidine on tRNA	45
Robust Chemoenzymatic Synthesis of Keratinimicin Aglycone Analogues Facilitated by the Structure and Selectivity of OxyB	45
Reengineering of Circularly Permuted Caspase-2 to Enhance Enzyme Stability and Enable Crystallographic Studies	44
Repurposing of the RIPK1-Selective Benzo[1,4]oxazepin-4-one Scaffold for the Development of a Type III LIMK1/2 Inhibitor	43
Dichlorophenylpyridine-Based Molecules Inhibit Furin through an Induced-Fit Mechanism	42
Chemical Synthetic Lethality Screens Identify Selective Drug Combinations against Pseudomonas aeruginosa	42
Biosynthesis of Physcion and Identification of an O-Methyltransferase with C6–OH Selectivity in Aspergillus chevalieri BYST01	41
Spontaneous Cleavage at Glu and Gln Residues in Long-Lived Proteins	40
Deposition Bias of Chromatin Proteins Inverts under DNA Replication Stress Conditions	40

Structure and Function of the β-Asp-Arg Polymerase Cyanophycin Synthetase 2	40
A Nonfunctional Halogenase Masquerades as an Aromatizing Dehydratase in Biosynthesis of Pyrrolic Polyketides by Type I Polyketide Synthases	39
Enzymatic Macrolactamization of mRNA Display Libraries for Inhibitor Selection	39
HiBiT-SpyTag: A Minimal Tag for Covalent Protein Capture and Degrader Development	39
An Inherent Difference between Serine and Threonine Phosphorylation: Phosphothreonine Strongly Prefers a Highly Ordered, Compact, Cyclic Conformation	38
Issue Publication Information	37
Enzymatic Pathway for Kupyaphore Degradation in Mycobacterium tuberculosis: Mechanism of Metal Homeostasis and Turnover	36
Discovery and Validation of a Novel Class of Necroptosis Inhibitors Targeting RIPK1	35
Issue Editorial Masthead	35
Analysis of the Valgamicin Biosynthetic Pathway Reveals a General Mechanism for Cyclopropanol Formation across Diverse Natural Product Scaffolds	34
Mechanistic Studies on Dehydration in Class V Lanthipeptides	34
Small-Molecule FICD Inhibitors Suppress Endogenous and Pathologic FICD-Mediated Protein AMPylation	33
Region-Specific and Age-Dependent Multitarget Effects of Acetylcholinesterase Inhibitor Tacrine on Comprehensive Neurotransmitter Systems	33
Lanmodulin’s EF 2–3 Domain: Insights from Infrared Spectroscopy and Simulations	31
Chemical Genetics in C. elegans Identifies Anticancer Mycotoxins Chaetocin and Chetomin as Potent Inducers of a Nuclear Metal Homeostasis Response	31
Development of Potent Dual BET/HDAC Inhibitors via Pharmacophore Merging and Structure-Guided Optimization	31
Split–Combine Click-SELEX Reveals Ligands Recognizing the Transplant Rejection Biomarker CXCL9	30
C₃-Symmetric Aromatic Core of Griffithsin Is Essential for Potent Anti-HIV Activity	30
Laboratory Evolution of Metalloid Reductase Substrate Recognition and Nanoparticle Product Size	29
Photoactivatable Plant Hormone-Based Chemical Inducers of Proximity for In Vivo Applications	29
2-Cyanopyrimidine-Containing Molecules for N-Terminal Selective Cyclization of Phage-Displayed Peptides	28
Labeling of CC Chemokine Receptor 2 with a Versatile Intracellular Allosteric Probe	28
Covalent Catalytic Strategies for Enzymes That Modify RNA Molecules on their Tripartite Building Blocks	28
Christopher T. Walsh: A Prolific Scientist, Effective Academic Leader, and Responsive Mentor	27
Targeted Discovery of Cryptic Enediyne Natural Products via FRET-Coupled High-Throughput Elicitor Screening	27
ACS Chemical Biology─2022 Editorial Statement	27
Phage Display Selection against a Mixture of Protein Targets	27
Repurposing the Damage Repair Protein Methyl Guanine Methyl Transferase as a Ligand Inducible Fusion Degron	27
Engineering a Low-Immunogenic Mirror-Image VHH against Vascular Endothelial Growth Factor	26
Light-Inducible Activation of TrkA for Probing Chronic Pain in Mice	26
Exploring Protein S-Palmitoylation: Mechanisms, Detection, and Strategies for Inhibitor Discovery	26
Inhibitors of the PqsR Quorum-Sensing Receptor Reveal Differential Roles for PqsE and RhlI in Control of Phenazine Production	26
Issue Publication Information	25
MYC-Targeting PROTACs Lead to Bimodal Degradation and N-Terminal Truncation	25
Issue Editorial Masthead	25
Issue Editorial Masthead	25
Issue Publication Information	25
An RNA Methylation-Sensitive AIEgen-Aptamer Reporting System for Quantitatively Evaluating m⁶A Methylase and Demethylase Activities	24
Bacterial Toxins Escape the Endosome by Inducing Vesicle Budding and Collapse	24
Design of Class I/IV Bromodomain-Targeting Degraders for Chromatin Remodeling Complexes	24
High-Speed Diagnosis of Bacterial Pathogens at the Single Cell Level by Raman Microspectroscopy with Machine Learning Filters and Denoising Autoencoders	24
A Sort-Seq Approach to the Development of Single Fluorescent Protein Biosensors	23
A Novel Lysosome Targeting Chimera for Targeted Protein Degradation via Split-and-Mix Strategy	23
Genome-Guided Discovery of the Myxobacterial Thiolactone-Containing Sorangibactins	23
Convergent Alterations of a Protein Hub Produce Divergent Effects within a Binding Site	23
Identification of Rapaglutin E as an Isoform-Specific Inhibitor of Glucose Transporter 1	23
Mechanistic Impact of Different Ligand Scaffolds on FXR Modulation Suggests Avenues to Selective Modulators	23
Insights into Substrate Recognition by the Unusual Nitrating Enzyme RufO	23
Clotrimazole-Based Modulators of the TRPM3 Ion Channel Reveal Narrow Structure–Activity Relationship	23
Bifunctional Sesquiterpene/Diterpene Synthase Agr2 from Cyclocybe aegerita Gives Rise to the Novel Diterpene Cyclocybene	22

Tetrazine-Ligated CRISPR sgRNAs for Efficient Genome Editing	22
Synthesis and Properties of RNA Modified with Cationic Amine Internucleoside Linkage	22
Biosynthesis of the Azoxy Compound Azodyrecin from Streptomyces mirabilis P8-A2	22
In Silico Discovery of Group II Intron RNA Splicing Inhibitors	22
SETDB1 Triple Tudor Domain Ligand, (R,R)-59, Promotes Methylation of Akt1 in Cells	22
What Is the Crystallographic Resolution of Structural Models of Proteins Generated with AlphaFold2?	22
Introducing Our Authors	22
Optimizing Peptide-Conjugated Lipid Nanoparticles for Efficient siRNA Delivery across the Blood–Brain Barrier and Treatment of Glioblastoma Multiforme	21
A Plastic Biosynthetic Pathway for the Production of Structurally Distinct Microbial Sunscreens	21
Characterization of Endogenous and Extruded H₂S and Small Oxoacids of Sulfur (SOS) in Cell Cultures	21
Chemical Therapies for Congenital Disorders of Glycosylation	21
Issue Editorial Masthead	21
PPARγ Corepression Involves Alternate Ligand Conformation and Inflation of H12 Ensembles	21
Bioproduction of a Large-Scale Library of Tryptamine Derivatives for Neuropsychiatric Drug Screening	21
Structures of Methanomethylophilus alvus Pyrrolysine tRNA-Synthetases Support the Need for De Novo Selections When Altering the Substrate Specificity	21
Structure-Based Discovery of Negative Allosteric Modulators of the Metabotropic Glutamate Receptor 5	21
Issue Editorial Masthead	21
Comparative Analysis of Drug-like EP300/CREBBP Acetyltransferase Inhibitors	21
Native Aminoacyl-tRNA Synthetase/tRNA Pair Drives Highly Efficient Noncanonical Amino Acid Incorporation in Escherichia coli	21
Directed Evolution of PD-L1-Targeted Affibodies by mRNA Display	21
Beyond KRAS(G12C): Biochemical and Computational Characterization of Sotorasib and Adagrasib Binding Specificity and the Critical Role of H95 and Y96	21
Tryptamine Metabolism and Functionalization in Gut Commensal Bacteria Expand Human Tryptamine Signaling Responses	21
Multiparametric High-Content Cell Painting Identifies Copper Ionophores as Selective Modulators of Esophageal Cancer Phenotypes	21
Targeting Gαi/s Proteins with Peptidyl Nucleotide Exchange Modulators	20
Combined In-Solution Fragment Screening and Crystallographic Binding-Mode Analysis with a Two-Domain Hsp70 Construct	20
Genome Mining of Myxopeptins Reveals a Class of Lanthipeptide-Derived Linear Dehydroamino Acid-Containing Peptides from Myxococcus sp. MCy9171	20
Drug-Like Small Molecules That Inhibit Expression of the Oncogenic MicroRNA-21	20
Endogenous ROS-Mediated Covalent Immobilization of Gold Nanoparticles in Mitochondria: A “Sharp Sword” in Tumor Radiotherapy	20
Correction to “Analysis of the Sequence Preference of Saporin by Deep Sequencing”	20
G Protein-Biased Agonists for Intracellular Angiotensin Receptors Promote Collagen Secretion in Myofibroblasts	20
Fitness Landscape-Guided Engineering of Locally Supercharged Virus-like Particles with Enhanced Cell Uptake Properties	20
Cyclative Release Strategy to Obtain Pure Cyclic Peptides Directly from the Solid Phase	20
In Situ Assembly of Transmembrane Proteins from Expressed and Synthetic Components in Giant Unilamellar Vesicles	20
Chemical Approaches To Investigate Post-transcriptional RNA Regulation	20
Widespread, Reversible Cysteine Modification by Methylglyoxal Regulates Metabolic Enzyme Function	20
The Relationship between Substrate Structure and Selectivity of Ketoreduction in Multimodular Polyketide Synthases: A Comparative Study of A-Type Ketoreductases from Late Modules Using Complex Precurs	19
Functional Characterization of Structural Genomics Proteins in the Crotonase Superfamily	19
Development of Comprehensive Screening and Assessment Assays for Small-Molecule Ligands of MALAT1 lncRNA	19
Characterization of Chemical Interactions between Clinical Drugs and the Oral Bacterium, Corynebacterium matruchotii, via Bioactivity-HiTES	19
Advances in Optogenetics and Thermogenetics for Control of Non-Neuronal Cells and Tissues in Biomedical Research	19
Structure and Function of a Dual Reductase–Dehydratase Enzyme System Involved in p-Terphenyl Biosynthesis	19
Blinking Fluorescent Probes for Tubulin Nanoscopy in Living and Fixed Cells	19
Site-Specific Introduction of Alanines for the Nuclear Magnetic Resonance Investigation of Low-Complexity Regions and Large Biomolecular Assemblies	19
Screen for Modulation of Nucleocapsid Protein Condensation Identifies Small Molecules with Anti-Coronavirus Activity	19
Insights into Free Drug Release from Efficacious N-Acyl O-Aminophenol Duocarmycin Prodrugs	19
Mapping snoRNA Targets Transcriptome-Wide with snoKARR-seq	19
Stable Isotope-Guided Metabolomics Reveals Polar-Functionalized Fatty-Acylated RiPPs from Streptomyces	19
Pathogenic SNPs Affect Both RNA and DNA G-Quadruplexes’ Responses to Ligands	19
Chemoenzymatic Probes Reveal Peptidoglycan Recognition and Uptake Mechanisms in Candida albicans	18
Multimodal Blood-Based Biomarker Panel Reveals Altered Lysosomal Ionic Content in Alzheimer’s Disease	18
Issue Publication Information	18
Discovery of a Compound That Inhibits IRE1α S-Nitrosylation and Preserves the Endoplasmic Reticulum Stress Response under Nitrosative Stress	18
Structural, Biochemical, and Bioinformatic Basis for Identifying Radical SAM Cyclopropyl Synthases	18
Selective Neutral pH Inhibitor of Cathepsin B Designed Based on Cleavage Preferences at Cytosolic and Lysosomal pH Conditions	18
Issue Editorial Masthead	18
Issue Publication Information	18
Metabolic Glycan Labeling in Primary Neurons Enabled by Unnatural Sugars with No S-Glyco-Modification	18
Activity-Based Diagnostics: Recent Advances in the Development of Probes for Use with Diverse Detection Modalities	18
Modulation of Specialized Metabolite Production in Genetically Engineered Streptomyces pactum	18
Biphasic Cellular Response Triggered by Tetrandrine-Mediated Dysfunction and Lysophagic Clearance of Lysosomes	18
Issue Publication Information	17
Correction to “A cAMP Sensor Based on Ligand-Dependent Protein Stabilization”	17
Targeted Protein Degradation through Recruitment of the CUL4 Complex Adaptor Protein DDB1	17
Development of a Benzothiazole Scaffold-Based Androgen Receptor N-Terminal Inhibitor for Treating Androgen-Responsive Prostate Cancer	17
Real-Time Cellular Thermal Shift Assay to Monitor Target Engagement	17
Writing and Erasing O-GlcNAc on Casein Kinase 2 Alpha Alters the Phosphoproteome	17
Synthetic ERRα/β/γ Agonist Induces an ERRα-Dependent Acute Aerobic Exercise Response and Enhances Exercise Capacity	17
Fluorinated Phosphoadenosine 5′-Phosphosulfate Analogues for Continuous Sulfotransferase Activity Monitoring and Inhibitor Screening by ¹⁹F NMR Spectroscopy	17
Adenylation Domain-Guided Recruitment of Trans-Acting Nonheme Monooxygenases in Nonribosomal Peptide Biosynthesis	17
Omniligase-1-Mediated Phage-Peptide Library Modification and Insulin Engineering	17
Issue Publication Information	17
Mechanistic Analysis of Bioorthogonal Double Strain-Promoted Alkyne–Nitrone Cycloadditions Involving Dibenzocyclooctadiyne	17
Drugging the Sarcomere, a Delicate Balance: Position of N-Terminal Charge of the Inhibitor W7	17
Chemoproteomic Profiling Reveals the Mechanism of Bile Acid Tolerance in Bacteria	17
Studies Pertaining to the Emerging Cannabinoid Hexahydrocannabinol (HHC)	17
Borinic Acid-Based Fluorogenic Probes as an Alternative to the Amplex Red Assay for Real-Time H₂O₂ Monitoring in Live Cells	16
Fungal NRPS-PKS Hybrid Enzymes Biosynthesize New γ-Lactam Compounds, Taslactams A-D, Analogous to Actinomycete Proteasome Inhibitors	16
Fluorescent Ligands Targeting the Intracellular Allosteric Binding Site of the Chemokine Receptor CCR2	16
Issue Publication Information	16
Development and Efficacy of an Orally Bioavailable Selective TAK1 Inhibitor for the Treatment of Inflammatory Arthritis	16

Enhancing the Anticancer Activity of Attenuated Listeria monocytogenes by Cell Wall Functionalization with “Clickable” Doxorubicin	16
Protein-Labeling Reagents Selectively Activated by Copper(I)	16
New High-Throughput Screen Discovers Novel Ligands of Full-Length Nuclear Receptor LRH-1	16
Elucidating the Role of the Competence Regulon Quorum Sensing Circuitry in Streptococcus cristatus	15
Discovery and Mechanism of 16–19F, a Novel Synthetic Lethal Inhibitor of the PRMT5•MTA Complex in MTAP-Deleted Cancer Cells	15
A Repurposed Drug Interferes with Nucleic Acid to Inhibit the Dual Activities of Coronavirus Nsp13	15
A Fluorescence Polarization Assay for Macrodomains Facilitates the Identification of Potent Inhibitors of the SARS-CoV-2 Macrodomain	15
Clostridioides difficile TcdB Toxin Glucosylates Rho GTPase by an S_Ni Mechanism and Ion Pair Transition State	15
Uncovering the Association Mechanism between Two Intrinsically Flexible Proteins	15
In-Depth Site-Specific O-Glycosylation Analysis of Glycoproteins and Endogenous Peptides in Cerebrospinal Fluid (CSF) from Healthy Individuals, Mild Cognitive Impairment (MCI), and Alzheimer’s Disease	15
Identification of Chemical Probes Targeting MBD2	15
The HPK1 Inhibitor A-745 Verifies the Potential of Modulating T Cell Kinase Signaling for Immunotherapy	15
Decay of Piwi-Interacting RNAs in Human Cells Is Primarily Mediated by 5′ to 3′ Exoribonucleases	15
The Impact of Sugar Conformation on the Single-Stranded DNA Selectivity of APOBEC3A and APOBEC3B Enzymes	15
Phenotypic Screening for Small Molecules that Protect β-Cells from Glucolipotoxicity	15
Design, Synthesis, and Mechanistic Studies of (R)-3-Amino-5,5-difluorocyclohex-1-ene-1-carboxylic Acid as an Inactivator of Human Ornithine Aminotransferase	15
Structural Insights into Spare-Tire DNA G-Quadruplex from the Human VEGF Promoter	15
CH−π Interactions in Glycan Recognition	15
Neurotoxic Implications of Human Coronaviruses in Neurodegenerative Diseases: A Perspective from Amyloid Aggregation	15
Dual-Probe Activity-Based Protein Profiling Reveals Site-Specific Differences in Protein Binding of EGFR-Directed Drugs	15
Phage Display of Two Distinct Warheads to Inhibit Challenging Proteins	14
Development of a New DHFR-Based Destabilizing Domain with Enhanced Basal Turnover and Applicability in Mammalian Systems	14
Improved Electrophile Design for Exquisite Covalent Molecule Selectivity	14
Kinetic and Thermodynamic Insights into Agonist Interactions with the Parathyroid Hormone Receptor-1 from a New NanoBRET Assay	14
Decoding the Mechanism of Specific RNA Targeting by Ribosomal Methyltransferases	14
Identification of NQO2 As a Protein Target in Small Molecule Modulation of Hepatocellular Function	14
Visualizing Intracellular Localization of Natural-Product-Based Chemical Probes Using Click-Correlative Light and Electron Microscopy	14
Combined Effect of Anti-SSEA4 and Anti-Globo H Antibodies on Breast Cancer Cells	14
Introducing Our Authors	14
Acarbose May Function as a Competitive Exclusion Agent for the Producing Bacteria	14
Biosynthesis of Bacillus Phosphonoalamides Reveals Highly Specific Amino Acid Ligation	14
Biotin as a Reactive Handle to Selectively Label Proteins and DNA with Small Molecules	14
Correction to “Suppression of DNA Polymerase β Activity is Synthetically Lethal in BRCA1-Deficient Cells”	14
Regulatory and Catalytic Domains of Poly(ADP-ribose) Polymerases Cross-Complement for DNA-Break-Dependent Allosteric Stimulation of Catalytic Activity	14
Discovery of Cyclic Lipopeptides Ralstopeptins A and B from Ralstonia solanacearum Species Complex and Analysis of Biosynthetic Gene Evolution	14
Structural Insights and Reaction Profile of a New Unspecific Peroxygenase from Marasmius wettsteinii Produced in a Tandem-Yeast Expression System	14
A Tandem-Affinity Purification Method for Identification of Primary Intracellular Drug-Binding Proteins	14
Targeting Protein Interaction Hotspots Using Structured and Disordered Chimeric Peptide Inhibitors	14
Leveraging Covalency to Stabilize Ternary Complex Formation For Cell–Cell “Induced Proximity”	14
Dual-Mechanism Confers Self-Resistance to the Antituberculosis Antibiotic Capreomycin	14
Treatment of Respiratory Distress Syndrome with Single Recombinant Polypeptides that Combine Features of SP-B and SP-C	14
A Capture Strategy for the Identification of Thio-Templated Metabolites	14
Novel Substrate Prediction for the TAM Family of RTKs Using Phosphoproteomics and Structure-Based Modeling	14
DNA-Encoded Library Technology─A Catalyst for Covalent Ligand Discovery	13
Cooperative Membrane Damage as a Mechanism for Pentamidine–Antibiotic Mutual Sensitization	13
The Base-Editing Enzyme APOBEC3A Catalyzes Cytosine Deamination in RNA with Low Proficiency and High Selectivity	13
Localized Light-Triggered CO Delivery: Comparing the Amount of CO Delivered and Cellular Toxicity	13
Unraveling the Photoactivation Mechanism of a Light-Activated Adenylyl Cyclase Using Ultrafast Spectroscopy Coupled with Unnatural Amino Acid Mutagenesis	13
Metabolic Investigation and Auxiliary Enzyme Modelization of the Pyrrocidine Pathway Allow Rationalization of Paracyclophane-Decahydrofluorene Formation	13
Identification of DDX5 as a Potential Therapeutic Target of Osteosarcoma Using Thiazolone Probes	13
Rapid Evaluation of Staple Placement in Stabilized α Helices Using Bacterial Surface Display	13
Engineered SH2 Domains for Targeted Phosphoproteomics	13
A Scavenger Hunt for a DyP-Peroxidase from a Metagenome: Curated Peroxidase Database-Assisted Primer Design and Protein Structure Elucidation	13
Chemical Interrogation of Nuclear Size Identifies Compounds with Cancer Cell Line-Specific Effects on Migration and Invasion	13
Switching Prenyl Donor Specificities in Squalene Synthase-Like Aromatic Prenyltransferases from Bacterial Carbazole Alkaloid Biosynthesis	13
Cytochrome P450 Mining for Bufadienolide Diversification	13
Identification of a Selective Pharmacologic IRE1/XBP1s Activator with Enhanced Tissue Exposure	13
Time-Dependent Studies of Oxaliplatin and Other Nucleolar Stress-Inducing Pt(II) Derivatives	13
Extrapolating Lessons from Targeted Protein Degradation to Other Proximity-Inducing Drugs	13
Charge Assisted S/Se Chalcogen Bonds in SAM Riboswitches: A Combined PDB and ab Initio Study	13
Genome-wide CRISPR Screening to Identify Drivers of TGF-β-Induced Liver Fibrosis in Human Hepatic Stellate Cells	13
Sustainable B₁₂-Dependent Dehalogenation of Organohalides in E. coli	13
MicroED as a Powerful Tool for Structure Determination of Macrocyclic Drug Compounds Directly from Their Powder Formulations	13
Machine Learning Uncovers Natural Product Modulators of the 5-Lipoxygenase Pathway and Facilitates the Elucidation of Their Biological Mechanisms	13
Selection of Optimal Cell Lines for High-Content Phenotypic Screening	13
Class IIb Microcin MccM Interferes with Oxidative Phosphorylation in Escherichia coli	13
Issue Publication Information	13
Tandem Chemoimmunotherapy by a Cascade-Responsive Molecular Prodrug	13
Forward Genetic Screens Identify Mechanisms of Resistance to Small-Molecule Lactate Dehydrogenase Inhibitors	13
Brominated Carbazole with Antibiotic Adjuvant Activity Displays Pleiotropic Effects in MRSA’s Transcriptome	13
Structure and Biosynthesis of Hectoramide B, a Linear Depsipeptide from Marine Cyanobacterium Moorena producens JHB Discovered via Coculture with Candida albicans	13
Synthesis of Differentially Halogenated Lissoclimide Analogues To Probe Ribosome E-Site Binding	13
Galectin-9 Signaling Drives Breast Cancer Invasion through Extracellular Matrix	13
Screening a Molecular Fragment Library to Modulate the PED/PEA15-Phospholipase D1 Interaction in Cellular Lysate Environments	13
General Approach to Identify, Assess, and Characterize Inhibitors of Lipid Peroxidation and Associated Cell Death	13
Issue Editorial Masthead	13
Inhibition of Mycobacterium tuberculosis Dethiobiotin Synthase (MtDTBS): Toward Next-Generation Antituberculosis Agents	13
Structure and Energetics of GTP- and GDP-Tubulin Isodesmic Self-Association	12
Bright Red Bioluminescence from Semisynthetic NanoLuc (sNLuc)	12
Analogs of NIH Molecular Probe ML283 Are Potent SARS-CoV-2 Helicase Inhibitors	12
Engineered Branaplam Aptamers Exploit Structural Elements from Natural Riboswitches	12
Introducing Our Authors	12
Proximity Labeling Reveals Spatial Regulation of the Anaphase-Promoting Complex/Cyclosome by a Microtubule Adaptor	12
Chemical Scaffolds for the Clinical Development of Mutant-Selective and Reversible Fourth-Generation EGFR-TKIs in NSCLC	12
European Robin Cryptochrome-4a Associates with Lipid Bilayers in an Ordered Manner, Fulfilling a Molecular-Level Condition for Magnetoreception	12
Targeted Manipulation of Cellular RNA m⁶A Methylation at the Single-Base Level	12
Chemical Proteomics with Novel Fully Functionalized Fragments and Stringent Target Prioritization Identifies the Glutathione-Dependent Isomerase GSTZ1 as a Lung Cancer Target	12
High-Throughput Screening for Extracellular Inhibitors of the FLT3 Receptor Tyrosine Kinase Reveals Chemically Diverse and Druggable Negative Allosteric Modulators	12
Origin of the Different Binding Affinities of (9R)- and (9S)-Hexahydrocannabinol (HHC) for the CB₁ and CB₂ Cannabinoid Receptors	12
A C-Degron Structure-Based Approach for the Development of Ligands Targeting the E3 Ligase TRIM7	12
N-Arylpyrazole NOD2 Agonists Promote Immune Checkpoint Inhibitor Therapy	12
Characterization of RufT Thioesterase Domain Reveals Insights into Rufomycin Cyclization and the Biosynthetic Origin of Rufomyazine	12
Selective and Potent PROTAC Degraders of c-Src Kinase	12
A “Goldilocks Zone” for Recruiting BET Proteins with Bromodomain-1-Selective Ligands	12
Mechanistic Insights into Harmine-Mediated Inhibition of Human DNA Methyltransferases and Prostate Cancer Cell Growth	12