ACS Chemical Biology

Article	Citations
A Useful Guide to Lectin Binding: Machine-Learning Directed Annotation of 57 Unique Lectin Specificities	107
m6A-RNA Demethylase FTO Inhibitors Impair Self-Renewal in Glioblastoma Stem Cells	98
A Clinical-Stage Cysteine Protease Inhibitor blocks SARS-CoV-2 Infection of Human and Monkey Cells	72
A Nimbolide-Based Kinase Degrader Preferentially Degrades Oncogenic BCR-ABL	68
Deorphanizing Caspase-3 and Caspase-9 Substrates In and Out of Apoptosis with Deep Substrate Profiling	61
Structural Insights into PROTAC-Mediated Degradation of Bcl-xL	60
LPCAT3 Inhibitors Remodel the Polyunsaturated Phospholipid Content of Human Cells and Protect from Ferroptosis	58
SARS-CoV-2 RBD-Tetanus Toxoid Conjugate Vaccine Induces a Strong Neutralizing Immunity in Preclinical Studies	57
Cell-Penetrating Peptides Escape the Endosome by Inducing Vesicle Budding and Collapse	55
Selective Degradation of GSPT1 by Cereblon Modulators Identified via a Focused Combinatorial Library	54
Modulation of Phosphoprotein Activity by Phosphorylation Targeting Chimeras (PhosTACs)	53
Biosynthesis of Cittilins, Unusual Ribosomally Synthesized and Post-translationally Modified Peptides from Myxococcus xanthus	47
Brightening up Biology: Advances in Luciferase Systems for in Vivo Imaging	45
Near-Infrared Fluorescent Probes for the Detection of Cancer-Associated Proteases	43
The SARS-CoV-2 Programmed −1 Ribosomal Frameshifting Element Crystal Structure Solved to 2.09 Å Using Chaperone-Assisted RNA Crystallography	41
Coibamide A Targets Sec61 to Prevent Biogenesis of Secretory and Membrane Proteins	40
Genetic Encoding of Three Distinct Noncanonical Amino Acids Using Reprogrammed Initiator and Nonsense Codons	39
Unveiling of Swainsonine Biosynthesis via a Multibranched Pathway in Fungi	38
Chalcogen Bonds Involving Selenium in Protein Structures	38
CH−π Interactions in Glycan Recognition	38
NanoClick: A High Throughput, Target-Agnostic Peptide Cell Permeability Assay	38
Light-Driven Activation of RNA-Guided Nucleic Acid Cleavage	37
Roadmap for Optimizing and Broadening Antibody-Based PROTACs for Degradation of Cell Surface Proteins	36
Nitrogen–Nitrogen Bond Formation Reactions Involved in Natural Product Biosynthesis	36
Plasmalogen Biosynthesis by Anaerobic Bacteria: Identification of a Two-Gene Operon Responsible for Plasmalogen Production in Clostridium perfringens	36

Attenuation of NLRP3 Inflammasome Activation by Indirubin-Derived PROTAC Targeting HDAC6	34
Carbohydrate Sulfation As a Mechanism for Fine-Tuning Siglec Ligands	33
Structural Characterization of Degrader-Induced Ternary Complexes Using Hydrogen–Deuterium Exchange Mass Spectrometry and Computational Modeling: Implications for Structure-Based Design	33
Bioinformatics-Guided Expansion and Discovery of Graspetides	33
Selective Transformations of Carbohydrates Inspired by Radical-Based Enzymatic Mechanisms	33
Machine Learning Classifies Ferroptosis and Apoptosis Cell Death Modalities with TfR1 Immunostaining	33
l-Threonine Transaldolase Activity Is Enabled by a Persistent Catalytic Intermediate	32
Spatiotemporal Control of Biology: Synthetic Photochemistry Toolbox with Far-Red and Near-Infrared Light	30
Chemical Screen for Vancomycin Antagonism Uncovers Probes of the Gram-Negative Outer Membrane	30
Structural Analysis of Class I Lanthipeptides from Pedobacter lusitanus NL19 Reveals an Unusual Ring Pattern	29
Ketosynthase Domain Constrains the Design of Polyketide Synthases	29
Chemical Diversification of Simple Synthetic Antibodies	29
High-Throughput Activity Assay for Screening Inhibitors of the SARS-CoV-2 Mac1 Macrodomain	29
Development of a Red-Light-Controllable Nitric Oxide Releaser to Control Smooth Muscle Relaxation in Vivo	29
Aptamer-T Cell Targeted Therapy for Tumor Treatment Using Sugar Metabolism and Click Chemistry	28
Inhibitor Mimetic Mutations in the Pseudomonas aeruginosa PqsE Enzyme Reveal a Protein–Protein Interaction with the Quorum-Sensing Receptor RhlR That Is Vital for Virulence Factor Production	28
Genetic Incorporation of Two Mutually Orthogonal Bioorthogonal Amino Acids That Enable Efficient Protein Dual-Labeling in Cells	28
Unraveling the Mechanism of a LOV Domain Optogenetic Sensor: A Glutamine Lever Induces Unfolding of the Jα Helix	28
The Promise and Peril of Chemical Probe Negative Controls	28
Identifying the Target of an Antiparasitic Compound in Toxoplasma Using Thermal Proteome Profiling	28
Fluorescence Probes Exhibit Photoinduced Structural Planarization: Sensing In Vitro and In Vivo Microscopic Dynamics of Viscosity Free from Polarity Interference	28
Uptake, Stability, and Activity of Antisense Anti-acpP PNA-Peptide Conjugates in Escherichia coli and the Role of SbmA	28
Fluorescence Anisotropy-Based Tethering for Discovery of Protein–Protein Interaction Stabilizers	27
Improving Membrane Permeation in the Beyond Rule-of-Five Space by Using Prodrugs to Mask Hydrogen Bond Donors	27
Identification of a Small Molecule That Enhances Ferroptosis via Inhibition of Ferroptosis Suppressor Protein 1 (FSP1)	27
A Probe for NLRP3 Inflammasome Inhibitor MCC950 Identifies Carbonic Anhydrase 2 as a Novel Target	27
Selective Neutral pH Inhibitor of Cathepsin B Designed Based on Cleavage Preferences at Cytosolic and Lysosomal pH Conditions	27
Optimization of Metabolic Oligosaccharide Engineering with Ac4GalNAlk and Ac4GlcNAlk by an Engineered Pyrophosphorylase	27
PEARL-seq: A Photoaffinity Platform for the Analysis of Small Molecule-RNA Interactions	27
Genetic and Biochemical Reconstitution of Bromoform Biosynthesis in Asparagopsis Lends Insights into Seaweed Reactive Oxygen Species Enzymology	27
A Review of Chemical Tools for Studying Small Molecule Persulfides: Detection and Delivery	26
Bioinformatic and Reactivity-Based Discovery of Linaridins	26
A Universal CAR-NK Cell Targeting Various Epitopes of HIV-1 gp160	26
Discovery and Characterization of a Class IV Lanthipeptide with a Nonoverlapping Ring Pattern	26
CRISPR Screen Reveals BRD2/4 Molecular Glue-like Degrader via Recruitment of DCAF16	26
Protein Folding Stability Changes Across the Proteome Reveal Targets of Cu Toxicity in E. coli	26
Non-Histone Protein Methylation: Biological Significance and Bioengineering Potential	26
A Gut-Restricted Lithocholic Acid Analog as an Inhibitor of Gut Bacterial Bile Salt Hydrolases	25
General and Robust Chemoenzymatic Method for Glycan-Mediated Site-Specific Labeling and Conjugation of Antibodies: Facile Synthesis of Homogeneous Antibody–Drug Conjugates	25
Improvement of Phycocyanobilin Synthesis for Genetically Encoded Phytochrome-Based Optogenetics	25
Profiling Sulfur(VI) Fluorides as Reactive Functionalities for Chemical Biology Tools and Expansion of the Ligandable Proteome	25
Nocardamine-Dependent Iron Uptake in Pseudomonas aeruginosa: Exclusive Involvement of the FoxA Outer Membrane Transporter	25
Mucinomics as the Next Frontier of Mass Spectrometry	25
First Small-Molecule Inhibitors Targeting the RNA-Binding Protein IGF2BP2/IMP2 for Cancer Therapy	25
Genome Mining Reveals the Phosphonoalamide Natural Products and a New Route in Phosphonic Acid Biosynthesis	25
The Angiopoietin-Like Protein 3 and 8 Complex Interacts with Lipoprotein Lipase and Induces LPL Cleavage	24
Allosteric Inhibition of Parkinson’s-Linked LRRK2 by Constrained Peptides	24
Multiplexed Photoactivation of mRNA with Single-Cell Resolution	24
Fluorescent Probes with Unnatural Amino Acids to Monitor Proteasome Activity in Real-Time	24
Blinking Fluorescent Probes for Tubulin Nanoscopy in Living and Fixed Cells	24

Local Stabilization of Subunit–Subunit Contacts Causes Global Destabilization of Hepatitis B Virus Capsids	23
Role of Iron in the Molecular Pathogenesis of Diseases and Therapeutic Opportunities	23
Short Photoswitchable Ceramides Enable Optical Control of Apoptosis	23
Intracellular Binding/Unbinding Kinetics of Approved Drugs to Carbonic Anhydrase II Observed by in-Cell NMR	23
Potent Inhibition of Necroptosis by Simultaneously Targeting Multiple Effectors of the Pathway	23
Cereblon Modulators Target ZBTB16 and Its Oncogenic Fusion Partners for Degradation via Distinct Structural Degrons	23
Comparison of N-Acetyl-Glucosamine to Other Monosaccharides Reveals Structural Differences for the Inhibition of α-Synuclein Aggregation	23
Cell Morphological Profiling Enables High-Throughput Screening for PROteolysis TArgeting Chimera (PROTAC) Phenotypic Signature	23
Configured for the Human Gut Microbiota: Molecular Mechanisms of Dietary β-Glucan Utilization	22
Enzymatic Formation of an Artificial Base Pair Using a Modified Purine Nucleoside Triphosphate	22
Impact of the Endosomal Escape Activity of Cell-Penetrating Peptides on the Endocytic Pathway	22
Development of an Acrylamide-Based Inhibitor of Protein S-Acylation	22
Site-Specific Chemoenzymatic Conjugation of High-Affinity M6P Glycan Ligands to Antibodies for Targeted Protein Degradation	22
Identification of SUMO Binding Proteins Enriched after Covalent Photo-Cross-Linking	22
Prenylation and Dehydrogenation of a C2-Reversely Prenylated Diketopiperazine as a Branching Point in the Biosynthesis of Echinulin Family Alkaloids in Aspergillus ruber	22
Site-Specific Lipidation Enhances IFITM3 Membrane Interactions and Antiviral Activity	21
R-BIND 2.0: An Updated Database of Bioactive RNA-Targeting Small Molecules and Associated RNA Secondary Structures	21
Genome Mining Discovery of Protegenins A–D, Bacterial Polyynes Involved in the Antioomycete and Biocontrol Activities of Pseudomonas protegens	21
Chemical Phosphoproteomics Sheds New Light on the Targets and Modes of Action of AKT Inhibitors	21
Facile Synthesis and Metabolic Incorporation of m-DAP Bioisosteres Into Cell Walls of Live Bacteria	20
Quorum Sensing Inhibition Attenuates the Virulence of the Plant Pathogen Ralstonia solanacearum Species Complex	20
The Nobel Prize in Chemistry 2022: Fulfilling Demanding Applications with Simple Reactions	20
Ribosomal Synthesis of Macrocyclic Peptides with β2- and β2,3-Homo-Amino Acids for the Development of Natural Product-Like Combinatorial Libraries	20
Strategies and Tactics for the Development of Selective Glycan-Binding Proteins	20
Bringing Vibrational Imaging to Chemical Biology with Molecular Probes	20
A DNA Aptamer for Theophylline with Ultrahigh Selectivity Reminiscent of the Classic RNA Aptamer	20
Dynamics of Hepatitis B Virus Capsid Protein Dimer Regulate Assembly through an Allosteric Network	20
YTHDF3 Facilitates eIF2AK2 and eIF3A Recruitment on mRNAs to Regulate Translational Processes in Oxaliplatin-Resistant Colorectal Cancer	20
Covalent Targeting of Ras G12C by Rationally Designed Peptidomimetics	20
Ribosomal Synthesis of Macrocyclic Peptides with Linear γ4- and β-Hydroxy-γ4-amino Acids	19
Mass Spectrometric Method for the Unambiguous Profiling of Cellular Dynamic Glycosylation	19
Reversible O-Acetyl Migration within the Sialic Acid Side Chain and Its Influence on Protein Recognition	19
High-Speed Diagnosis of Bacterial Pathogens at the Single Cell Level by Raman Microspectroscopy with Machine Learning Filters and Denoising Autoencoders	19
Chemical Labeling and Enrichment of Histone Glyoxal Adducts	19
Tolerogenic Nanoparticles Impacting B and T Lymphocyte Responses Delay Autoimmune Arthritis in K/BxN Mice	19
Reactivity-Based Screening for Citrulline-Containing Natural Products Reveals a Family of Bacterial Peptidyl Arginine Deiminases	19
Quantitative and Site-Specific Chemoproteomic Profiling of Protein O-GlcNAcylation in the Cell Cycle	19
Imaginary Ribozymes	19
How ATP-Competitive Inhibitors Allosterically Modulate Tyrosine Kinases That Contain a Src-like Regulatory Architecture	19
N-Myristoyltransferase as a Glycine and Lysine Myristoyltransferase in Cancer, Immunity, and Infections	19
YEATS Domains as Novel Epigenetic Readers: Structures, Functions, and Inhibitor Development	19
The Integrity of the Intradimer Interface of the Hepatitis B Virus Capsid Protein Dimer Regulates Capsid Self-Assembly	19
Synthetic Fluorinated l-Fucose Analogs Inhibit Proliferation of Cancer Cells and Primary Endothelial Cells	18
Cell-Specific Delivery Using an Engineered Protein Nanocage	18
S-Palmitoylation and Sterol Interactions Mediate Antiviral Specificity of IFITMs	18
An Allosteric Modulator of RNA Binding Targeting the N-Terminal Domain of TDP-43 Yields Neuroprotective Properties	18
Cysteine Hydropersulfide Inactivates β-Lactam Antibiotics with Formation of Ring-Opened Carbothioic S-Acids in Bacteria	18
Quantifying Intramolecular Halogen Bonds in Nucleic Acids: A Combined Protein Data Bank and Theoretical Study	18
Identifying Receptors for Neuropeptides and Peptide Hormones: Challenges and Recent Progress	18
Outer Membrane Vesicle-Mediated Codelivery of the Antifungal HSAF Metabolites and Lytic Polysaccharide Monooxygenase in the Predatory Lysobacter enzymogenes	18
Garcinol Is an HDAC11 Inhibitor	18
Unlocking Cryptic Metabolites with Mass Spectrometry-Guided Transposon Mutant Selection	18
Clinical Antiviral Drug Arbidol Inhibits Infection by SARS-CoV-2 and Variants through Direct Binding to the Spike Protein	18
Protected N-Acetyl Muramic Acid Probes Improve Bacterial Peptidoglycan Incorporation via Metabolic Labeling	18
Base Pairing and Functional Insights into N3-Methylcytidine (m3C) in RNA	18
Mechanistic Studies on Dehydration in Class V Lanthipeptides	18
A Bifunctional NAD+ for Profiling Poly-ADP-Ribosylation-Dependent Interacting Proteins	17
Release Factor Inhibiting Antimicrobial Peptides Improve Nonstandard Amino Acid Incorporation in Wild-type Bacterial Cells	17
Asparaginyl Ligase-Catalyzed One-Step Cell Surface Modification of Red Blood Cells	17
Discovery of Potent Small-Molecule Inhibitors of WDR5-MYC Interaction	17
Structural Characterization of Complex of Adenylation Domain and Carrier Protein by Using Pantetheine Cross-Linking Probe	17
Potential G-Quadruplex Forming Sequences and N6-Methyladenosine Colocalize at Human Pre-mRNA Intron Splice Sites	17
Bioactive Compounds of Arthrospira spp. (Spirulina) with Potential Anticancer Activities: A Systematic Review	17
Mass Spectrometry-Based Technology and Workflows for Studying the Chemistry of Fungal Endophyte Derived Bioactive Compounds	17
The Structural and Biochemical Basis of Apocarotenoid Processing by β-Carotene Oxygenase-2	17
Structural Basis for the Selective Inhibition of HDAC10, the Cytosolic Polyamine Deacetylase	17
Direct Binding of Salicylic Acid to Pectobacterium N-Acyl-Homoserine Lactone Synthase	17
Importance of the Cyclic Cystine Knot Structural Motif for Immunosuppressive Effects of Cyclotides	17
Metabolically Activated Proteostasis Regulators Protect against Glutamate Toxicity by Activating NRF2	17
Quantitative Measurement of Cytosolic and Nuclear Penetration of Oligonucleotide Therapeutics	17
Genomic-Led Discovery of a Novel Glycopeptide Antibiotic by Nonomuraea coxensis DSM 45129	17
Advancements in Assay Technologies and Strategies to Enable Drug Discovery	17
A Highly Efficacious Carfentanil Vaccine That Blunts Opioid-Induced Antinociception and Respiratory Depression	17
m7G-quant-seq: Quantitative Detection of RNA Internal N7-Methylguanosine	16
Systematic Assessment of Accessibility to the Surface of Staphylococcus aureus	16
Stabilization of Protein–Protein Interactions between CaMKK2 and 14–3–3 by Fusicoccins	16
Phenotype-Guided Comparative Genomics Identifies the Complete Transport Pathway of the Antimicrobial Lasso Peptide Ubonodin in Burkholderia	16
Gini Coefficients as a Single Value Metric to Define Chemical Probe Selectivity	16
Subsite Ligand Recognition and Cooperativity in the TPP Riboswitch: Implications for Fragment-Linking in RNA Ligand Discovery	16
Live-Cell Fluorescence Lifetime Multiplexing Using Synthetic Fluorescent Probes	16

Chemical Probes for Blocking of Influenza A M2 Wild-type and S31N Channels	15
A Comparison of Two Stability Proteomics Methods for Drug Target Identification in OnePot 2D Format	15
Engineering Cell-Permeable Proteins through Insertion of Cell-Penetrating Motifs into Surface Loops	15
Direct Sequencing of tRNA by 2D-HELS-AA MS Seq Reveals Its Different Isoforms and Dynamic Base Modifications	15
In Vitro Reconstitution of a Five-Step Pathway for Bacterial Ergothioneine Catabolism	15
Host Kinase CSNK2 is a Target for Inhibition of Pathogenic SARS-like β-Coronaviruses	15
Structure-Guided Optimization of Inhibitors of Acetyltransferase Eis from Mycobacterium tuberculosis	15
Targeted Protein Degradation through E2 Recruitment	15
Protein Proximity Observed Using Fluorogen Activating Protein and Dye Activated by Proximal Anchoring (FAP–DAPA) System	15
Tunable Heteroassembly of a Plant Pseudoenzyme–Enzyme Complex	15
Structural Insights into the Interaction of Clinically Relevant Phosphorothioate mRNA Cap Analogs with Translation Initiation Factor 4E Reveal Stabilization via Electrostatic Thio-Effect	15
Generation of a Large Peptide Phage Display Library by Self-Ligation of Whole-Plasmid PCR Product	15
Substrate Plasticity of a Fungal Peptide α-N-Methyltransferase	15
Biosynthesis of the Nuclear Factor of Activated T Cells Inhibitor NFAT-133 in Streptomyces pactum	15
The Progesterone 5β-Reductase/Iridoid Synthase Family: A Catalytic Reservoir for Specialized Metabolism across Land Plants	15
Addicting Escherichia coli to New-to-Nature Reactions	15
A Silent Biosynthetic Gene Cluster from a Methanotrophic Bacterium Potentiates Discovery of a Substrate Promiscuous Proteusin Cyclodehydratase	15
Affinity Mass Spectrometry-Based Fragment Screening Identified a New Negative Allosteric Modulator of the Adenosine A2A Receptor Targeting the Sodium Ion Pocket	15
Unraveling the Photoactivation Mechanism of a Light-Activated Adenylyl Cyclase Using Ultrafast Spectroscopy Coupled with Unnatural Amino Acid Mutagenesis	15
Complementary Genomic, Bioinformatics, and Chemical Approaches Facilitate the Absolute Structure Assignment of Ionostatin, a Linear Polyketide from a Rare Marine-Derived Actinomycete	15
Orthosteric and Allosteric Dual Targeting of the Nuclear Receptor RORγt with a Bitopic Ligand	15
ATE1-Mediated Post-Translational Arginylation Is an Essential Regulator of Eukaryotic Cellular Homeostasis	15
Exploring Methods of Targeting Histone Methyltransferases and Their Applications in Cancer Therapeutics	14
Chemical Inhibitors of a Selective SWI/SNF Function Synergize with ATR Inhibition in Cancer Cell Killing	14
Pharmacological Advantage of SIRT2-Selective versus pan-SIRT1–3 Inhibitors	14
Identification and Biosynthesis of Pro-Inflammatory Sulfonolipids from an Opportunistic Pathogen Chryseobacterium gleum	14
Photostable and Orthogonal Solvatochromic Fluorophores for Simultaneous In Situ Quantification of Multiple Cellular Signaling Molecules	14
“Clickable” ZIF-8 for Cell-Type-Specific Delivery of Functional Proteins	14
Precipitate-Supported Thermal Proteome Profiling Coupled with Deep Learning for Comprehensive Screening of Drug Target Proteins	14
Highly Sensitive Labeling Reagents for Scarce Natural Products	14
Short Peptides and Their Mimetics as Potent Antibacterial Agents and Antibiotic Adjuvants	14
Inhibition of the GDP-d-Mannose Dehydrogenase from Pseudomonas aeruginosa Using Targeted Sugar Nucleotide Probes	14
MetEx, a Metabolomics Explorer Application for Natural Product Discovery	14
Amyloid Fibril Formation of Arctic Amyloid-β 1–42 Peptide is Efficiently Inhibited by the BRICHOS Domain	14
Covalent and Noncovalent Targeting of the Tcf4/β-Catenin Strand Interface with β-Hairpin Mimics	14
Dark Dynamic Therapy: Photosensitization without Light Excitation Using Chemiluminescence Resonance Energy Transfer in a Dioxetane–Erythrosin B Conjugate	14
Pyridazine Nucleobase in Triplex-Forming PNA Improves Recognition of Cytosine Interruptions of Polypurine Tracts in RNA	14
Inhibition and Crystal Structure of the Human DHTKD1-Thiamin Diphosphate Complex	14
The HPK1 Inhibitor A-745 Verifies the Potential of Modulating T Cell Kinase Signaling for Immunotherapy	14
Angler Peptides: Macrocyclic Conjugates Inhibit p53:MDM2/X Interactions and Activate Apoptosis in Cancer Cells	14
Proteome-Wide Profiling of Cellular Targets Modified by Dopamine Metabolites Using a Bio-Orthogonally Functionalized Catecholamine	13
Detection of SARS-CoV-2 RNA Using a DNA Aptamer Mimic of Green Fluorescent Protein	13
Triple-Helical Binding of Peptide Nucleic Acid Inhibits Maturation of Endogenous MicroRNA-197	13
Multiparametric High-Content Cell Painting Identifies Copper Ionophores as Selective Modulators of Esophageal Cancer Phenotypes	13
Mediated Electrochemical Probing: A Systems-Level Tool for Redox Biology	13
Structure–Activity Relationship of Metabolic Sialic Acid Inhibitors and Labeling Reagents	13
Nucleosome Dynamics during Transcription Elongation	13
A Single Amino Acid Determines the Selectivity and Efficacy of Selective Negative Allosteric Modulators of CaV1.3 L-Type Calcium Channels	13
Galectin-9 Signaling Drives Breast Cancer Invasion through Extracellular Matrix	13
Proximity Tagging Identifies the Glycan-Mediated Glycoprotein Interactors of Galectin-1 in Muscle Stem Cells	13
Making the Enterobacterial Common Antigen Glycan and Measuring Its Substrate Sequestration	13
Activity-Based Diagnostics: Recent Advances in the Development of Probes for Use with Diverse Detection Modalities	13
Rescue of Glycosylphosphatidylinositol-Anchored Protein Biosynthesis Using Synthetic Glycosylphosphatidylinositol Oligosaccharides	13
Kinase Photoaffinity Labeling Reveals Low Selectivity Profile of the IRE1 Targeting Imidazopyrazine-Based KIRA6 Inhibitor	13
Ratiometric Bioluminescent Zinc Sensor Proteins to Quantify Serum and Intracellular Free Zn2+	13
The Shape of Nanostructures Encodes Immunomodulation of Carbohydrate Antigen and Vaccine Development	13
Validating Signal Transducer and Activator of Transcription (STAT) Protein–Inhibitor Interactions Using Biochemical and Cellular Thermal Shift Assays	13
Rational Redesign of Monoamine Oxidase A into a Dehydrogenase to Probe ROS in Cardiac Aging	13
An Optimized Isotopic Photocleavable Tagging Strategy for Site-Specific and Quantitative Profiling of Protein O-GlcNAcylation in Colorectal Cancer Metastasis	13
Fluorescence Lifetime Imaging of pH along the Secretory Pathway	13
Entropic Inhibition: How the Activity of a AAA+ Machine Is Modulated by Its Substrate-Binding Domain	13
Reconstitution and Structural Analysis of a HECT Ligase-Ubiquitin Complex via an Activity-Based Probe	13
Adenosine Triggers Larval Settlement and Metamorphosis in the Mussel Mytilopsis sallei through the ADK-AMPK-FoxO Pathway	13
Development of a Broadly Applicable Cas12a-Linked Beam Unlocking Reaction for Sensitive and Specific Detection of Respiratory Pathogens Including SARS-CoV-2	13
Controlling the Production of Pseudomonas Phenazines by Modulating the Genetic Repertoire	13
Biocatalytic in Vitro and in Vivo FMN Prenylation and (De)carboxylase Activation	13
Proof-Reading Thioesterase Boosts Activity of Engineered Nonribosomal Peptide Synthetase	13
Identification of Ubiquitin Variants That Inhibit the E2 Ubiquitin Conjugating Enzyme, Ube2k	13
Charge Assisted S/Se Chalcogen Bonds in SAM Riboswitches: A Combined PDB and ab Initio Study	13
Ferulic Acid Decarboxylase Controls Oxidative Maturation of the Prenylated Flavin Mononucleotide Cofactor	13
Single-Base Resolution Mapping Reveals Distinct 5-Formylcytidine in Saccharomyces cerevisiae mRNAs	13
Chemical and Biochemical Reactivity of the Reduced Forms of Nicotinamide Riboside	12
Potent Inhibitor of Human Trypsins from the Aeruginosin Family of Natural Products	12
Glycosylation Regulates N-Terminal Proteolysis and Activity of the Chemokine CCL14	12
Substrate Recognition by the Peptidyl-(S)-2-mercaptoglycine Synthase TglHI during 3-Thiaglutamate Biosynthesis	12
New Malonate-Derived Tetraglucoside Detergents for Membrane Protein Stability	12
Structure-Based De Novo Design of Mycobacterium Tuberculosis VapC-Activating Stapled Peptides	12
Structural Features of Small Molecules Targeting the RNA Repeat Expansion That Causes Genetically Defined ALS/FTD	12
Cell-surface Labeling via Bioorthogonal Host–Guest Chemistry	12
Targeted Discovery of Cryptic Metabolites with Antiproliferative Activity	12
Antibacterial Discovery via Phenotypic DNA-Encoded Library Screening	12
Enzymatic Plasticity Inspired by the Diterpene Cyclase CotB2	12
An Integrated Molecular Grafting Approach for the Design of Keap1-Targeted Peptide Inhibitors	12
Inhibiting HTLV-1 Protease: A Viable Antiviral Target	12
Nile Red-Based GPCR Ligands as Ultrasensitive Probes of the Local Lipid Microenvironment of the Receptor	12
Synergetic Roles of Formyl Peptide Receptor 1 Oligomerization in Ligand-Induced Signal Transduction	12
Genetically Encoded Benzoyllysines Serve as Versatile Probes for Interrogating Histone Benzoylation and Interactions in Living Cells	12
Novel Tetrafunctional Probes Identify Target Receptors and Binding Sites of Small-Molecule Drugs from Living Systems	12
A Molecular Logic Gate Enables Single-Molecule Imaging and Tracking of Lipids in Intracellular Domains	12
Optimization of PROTAC Ternary Complex Using DNA Encoded Library Approach	12
Capturing Differences in the Regulation of LRRK2 Dynamics and Conformational States by Small Molecule Kinase Inhibitors	12
Complete Chemical Synthesis of Minimal Messenger RNA by Efficient Chemical Capping Reaction	12
Synthesis of Asymmetric N-Glycans as Common Core Substrates for Structural Diversification through Selective Enzymatic Glycosylation	12
Spatiotemporal Proximity Labeling Tools to Track GlcNAc Sugar-Modified Functional Protein Hubs during Cellular Signaling	12
Sequential Linkage of Carbohydrate Antigens to Mimic Capsular Polysaccharides: Toward Semisynthetic Glycoconjugate Vaccine Candidates against Streptococcus pneumoniae Serotype 14	12