OOIR: Observatory of International Research

Papers

(The TQCC of Epigenetics is 8. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-07-01 to 2025-07-01.)

Article	Citations
Leukocyte DNA methylation in Alzheimer´s disease associated genes: replication of findings from neuronal cells	82
Disentangling tumorigenesis-associated DNA methylation changes in colorectal tissues from those associated with ageing	64
Epigenetic landscape of 5-hydroxymethylcytosine and associations with gene expression in placenta	42
Identification and functional characterisation of DNA methylation differences between East- and West-originating Finns	32
Role of N6-methyladenosine-related lncRnas in pseudoexfoliation glaucoma	30
GGNBP2 regulates histone ubiquitination and methylation in spermatogenesis	26
Placental DNA methylation in pregnancies complicated by maternal diabetes and/or obesity: State of the art and research gaps	25
Transcriptional signature of cardiac myocyte recovery in mice and human reveals persistent upregulation of epigenetic factors	24
Differential methylation patterns in cord blood associated with prenatal exposure to neighborhood crime: an epigenome-wide association study and regional analysis	23
Using methylation data to improve transcription factor binding prediction	23
Co-occurrence of injection drug use and hepatitis C increases epigenetic age acceleration that contributes to all-cause mortality among people living with HIV	22
N6-methyladenosine methylation analysis of long noncoding RNAs and mRNAs in 5-FU-resistant colon cancer cells	21
Digital methylation assessments of alcohol and cigarette consumption account for common variance in accelerated epigenetic ageing	21
Detailed immune profiling in pediatric Crohn’s disease using methylation cytometry	20
Placental malaria induces a unique methylation profile associated with fetal growth restriction	19
A novel lncRNA, Lnc21q22.11, suppresses gastric cancer growth by inhibiting MEK/ERK pathway	18
Proposal of a bioinformatics approach to predict molecular mechanisms involved in inflammatory response: case of ATRA and 1,25(OH) ₂ D in adipocytes	18
CircRNF111 Contributes to Adipocyte Differentiation by Elevating PPARγ Expression via miR-27a-3p	17
Differential methylation pattern in pubertal girls associated with biochemical premature adrenarche	17
Multiomics analysis of adaptation to repeated DNA damage in prostate cancer cells	17
Roles of adenine methylation and genetic mutations in adaptation to different temperatures in Serratia marcescens	17
The influence of intergenerational trauma on epigenetics and obesity in Indigenous populations - a scoping review	17
Generational stability of epigenetic transgenerational inheritance facilitates adaptation and evolution	16
Acetaldehyde-driven mRNA methylation and expression changes in ethanol-metabolizing enzyme genes	16
Identification cloning and functional analysis of novel natural antisense lncRNA CFL1-AS1 in cattle	16

The Socioeconomic Gradient in Epigenetic Ageing Clocks: Evidence from the Multi-Ethnic Study of Atherosclerosis and the Health and Retirement Study	16
Accelerated epigenetic age at birth and child emotional and behavioural development in early childhood: a meta-analysis of four prospective cohort studies in ECHO	16
Epigenome-wide association study of loneliness in a sample of U.S. middle-aged twins	15
Repurposing epigenetic inhibitors to target the Clostridioides difficile-specific DNA adenine methyltransferase and sporulation regulator CamA	15
MYCN and HIF-1 directly regulate TET1 expression to control 5-hmC gains and enhance neuroblastoma cell migration in hypoxia	15
The UHRF1 protein is a key regulator of retrotransposable elements and innate immune response to viral RNA in human cells	14
Direction-aware functional class scoring enrichment analysis of infinium DNA methylation data	14
Identification and characterization of extrachromosomal circular DNA in patients with high myopia and cataract	14
DNA methylome in visceral adipose tissue can discriminate patients with and without colorectal cancer	14
Genomic context determines the effect of DNA methylation on gene expression in the gut epithelium of Atlantic salmon ( Salmo salar )	14
Selenium-associated differentially expressed microRNAs and their targeted mRNAs across the placental genome in two U.S. birth cohorts	14
Blood DNA methylation signatures are associated with social determinants of health among survivors of childhood cancer	13
ELOVL2-AS1 suppresses tamoxifen resistance by sponging miR-1233-3p in breast cancer	13
Polymethylation scores for prenatal maternal smoke exposure persist until age 15 and are detected in saliva in the Fragile Families and Child Wellbeing cohort	13
Integration of miRNA expression analysis of purified leukocytes and whole blood reveals blood-borne candidate biomarkers for lung cancer	13
Validation of the new EPIC DNA methylation microarray (900K EPIC v2) for high-throughput profiling of the human DNA methylome	13
Placental and immune cell DNA methylation reference panel for bulk tissue cell composition estimation in epidemiological studies	13
Regulatory networks of circRNA- centred ceRNAs in sepsis-induced acute kidney injury	13
PIK3R1 and G0S2 are human placenta-specific imprinted genes associated with germline-inherited maternal DNA methylation	13
Pan-precancer and cancer DNA methylation profiles revealed significant tissue specificity of interrupted biological processes in tumorigenesis	13
Cut&tag: a powerful epigenetic tool for chromatin profiling	12
The one-carbon metabolism as an underlying pathway for placental DNA methylation – a systematic review	12
Chemotherapy-induced acceleration of DNA methylation-based biological age in breast cancer	12
Large-scale integration of DNA methylation and gene expression array platforms identifies both cis and trans relationships	12
Long non-coding RNA Gm10561 promotes myogenesis by sponging miR-432	12
Cumulative stress, PTSD, and emotion dysregulation during pregnancy and epigenetic age acceleration in Hispanic mothers and their newborn infants	12
Timing of dietary effects on the epigenome and their potential protective effects against toxins	12
Upregulation of KHDC1L promotes the proliferation and inhibits apoptosis in head and neck squamous cell carcinoma	12
CircRIMKLB promotes myoblast proliferation and inhibits differentiation by sponging miR-29c to release KCNJ12	12
Comprehensive analysis of m ⁶ A methylomes in idiopathic pulmonary arterial hypertension	11
Hypomethylation at H19DMR in penile squamous cell carcinoma is not related to HPV infection	11
Analysis of global DNA methylation and epigenetic modifiers (DNMTs and HDACs) in human foetal endothelium exposed to gestational and type 2 diabetes	11
DNA methylation at birth and fine motor ability in childhood: an epigenome-wide association study with replication	11
The role of DNA methylation on gene expression in the vertebrae of ancestrally benzo[a]pyrene exposed F1 and F3 male medaka	11
Associations between infant sex and DNA methylation across umbilical cord blood, artery, and placenta samples	11
Study on chromatin regulation patterns of expression vectors in the PhiC31 integration site	11
ΔNp63α-mediated epigenetic regulation in keratinocyte senescence	11
Direct bisulphite conversion of cervical samples for DNA methylation analysis	11
mir152hypomethylation as a mechanism for non-syndromic cleft lip and palate	11
DNA-based cell typing in menstrual effluent identifies cell type variation by sample collection method: toward noninvasive biomarker development for women’s health	11
DNA methylation changes in glial cells of the normal-appearing white matter in Multiple Sclerosis patients	11
Assessment of aberrant DNA methylation two years after paediatric critical illness: a pre-planned secondary analysis of the international PEPaNIC trial	10
Biological stability of DNA methylation measurements over varying intervals of time and in the presence of acute stress	10
Alterations in DNA methylation associate with fatty liver and metabolic abnormalities in a multi-ethnic cohort of pre-teenage children	10
Gaps in current methods to detect polymorphic CpGs from Illumina Infinium human methylation microarrays and exploring their potential impact in multi-EWAS analyses	10
Research progress on the mechanism of tumor cell ferroptosis regulation by epigenetics	10
Upregulation of GPR133 expression impaired the phagocytosis of macrophages in recurrent spontaneous miscarriage	10
RNA modification m ⁶ Am: the role in cardiac biology	10
DNA methylation profiles in bovine sperm are associated with daughter fertility	10
Dietary and supplemental intake of vitamins C and E is associated with altered DNA methylation in an epigenome-wide association study meta-analysis	10

Heavy alcohol consumption but not smoking predicts mortality in patients with acute coronary syndrome	10
Detecting aberrant DNA methylation in Illumina DNA methylation arrays: a toolbox and recommendations for its use	10
DNMT1 expression partially dictates 5-Azacytidine sensitivity and correlates with RAS/MEK/ERK activity in gastric cancer cells	10
Epigenetic age acceleration, neonatal morbidities, and neurobehavioral profiles in infants born very preterm	9
A novel principal component based method for identifying differentially methylated regions in Illumina Infinium MethylationEPIC BeadChip data	9
Prenatal Socioeconomic Disadvantage and Epigenetic Alterations at Birth Among Children Born to White British and Pakistani Mothers in the Born in Bradford Study	9
Dynamics of methylated cell-free DNA in the urine of non-small cell lung cancer patients	9
Epigenome wide association study in peripheral blood of pregnant women identifies potential metabolic pathways related to gestational diabetes	9
Comparative genomic analyses reveal evidence for adaptive A-to-I RNA editing in insect Adar gene	9
Oleic acid-related anti-inflammatory effects in force-stressed PdL fibroblasts are mediated by H3 lysine acetylation associated with altered IL10 expression	9
m6A reader YTHDC2 mediates NCOA4 mRNA stability affecting ferritinophagy to alleviate secondary injury after intracerebral haemorrhage	9
Methylome profile of medaka eggs and sperm	9
Novel DNA methylation loci and genes showing pleiotropic association with Alzheimer’s dementia: a network Mendelian randomization analysis	9
NSUN2-mediated RNA m⁵C modification modulates uveal melanoma cell proliferation and migration	9
Catalytic domain-dependent and -independent transcriptional activities of the tumour suppressor histone H3K27 demethylase UTX/KDM6A in specific cancer types	8
Epigenome-wide meta-analysis of prenatal vitamin D insufficiency and cord blood DNA methylation	8
Memory B-cell like chronic lymphocytic leukaemia is associated with specific methylation profile of WNT5A promoter and undetectable expression of WNT5A gene	8
Detection of DNA methylation from buccal swabs using nanopore sequencing to study stunting	8
DNA methylation and bronchiectasis: a Mendelian randomization analysis to investigate causal link and therapeutic target	8
Genetic and epigenetic analysis of the serotonin 2A receptor in the context of cocaine abuse	8
Methylation of FKBP5 is associated with accelerated DNA methylation ageing and cardiometabolic risk: replication in young-adult and middle-aged Black Americans	8
Genome-wide methylation analysis in patients with proximal hypospadias – a pilot study and review of the literature	8
Anthropometric, biochemical, and haematological indicators associated with hyperhomocysteinemia and their relation to global DNA methylation in a young adult population	8
Precise epigenomic editing with a SunTag-based modular epigenetic toolkit	8
DNA methylation biomarkers to identify epigenetically abnormal spermatozoa in male partners from couples experiencing recurrent pregnancy loss	8
Sirtuin1 in vascular endothelial function, an overview	8
History of exposure to copper influences transgenerational gene expression responses in Daphnia magna	8
Sex-based differences in placental DNA methylation profiles related to gestational age: an NIH ECHO meta-analysis	8
Stress-induced epigenetic effects driven by maternal lactation in dairy cattle: a comethylation network approach	8
Comparison of EM-seq and PBAT methylome library methods for low-input DNA	8
Higher sperm H3K4me3 levels are associated with idiopathic recurrent pregnancy loss	8
Time-course full profiling of circulating miRNAs in neurologically deceased organ donors: a proof of concept study to understand the onset of the cytokine storm	8
Uncertainty quantification of reference-based cellular deconvolution algorithms	8
Domain architecture and protein–protein interactions regulate KDM5A recruitment to the chromatin	8
Circ_0003747 promotes thyroid cancer progression by sponging miR-338-3p to upregulate PLCD3 expression	8
Comprehensive analysis of transcriptome‐wide M ⁶ A methylation for hepatic ischaemia reperfusion injury in mice	8