OOIR: Observatory of International Research

Papers

(The TQCC of Dose-Response is 6. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-04-01 to 2025-04-01.)

Article	Citations
Cefepime Dosing Requirements in Elderly Patients Attended in the Emergency Rooms	77
Paeoniflorin Inhibits Atrial Fibrosis and Atrial Fibrillation in Angiotensin II-Infused Mice Through the PI3K-Akt Pathway	66
Alumina-Hydroxyapatite-Silver Spheres With Antibacterial Activity	57
Radioactive ¹²⁵I Seed Inhibits Cell Migration and Invasion and Promotes Apoptosis by Inactivating the VEGFR2 Signaling Pathway in Cholangiocarcinoma	39
Bioinformatics-Based Approach for Exploring the Immune Cell Infiltration Patterns in Alzheimer’s Disease and Determining the Intervention Mechanism of Liuwei Dihuang Pill	37
Evaluation of Antiurolithiatic Effects of Moringa oleifera Lam. Leaves Extract: In-vitro, in-silico and in-vivo Approaches	30
Antitumor and Antibacterial Efficacy of Gallium Nanoparticles Coated by Ellagic Acid	26
Editorial: State of the Art CT and Image Quality, Radiation and Contrast Dose	25
Corilagin Alleviates Ang II-Induced Cardiac Fibrosis by Regulating the PTEN/AKT/mTOR Pathway	24
Condiment Recipes Lead to Reduced Generation of Carcinogenic Polycyclic Aromatic Hydrocarbons in Duck Variety Meat During Charcoal Grilling	23
Identification of Secondary Metabolites of Cyperus rotundus L. and Dose-dependent Effects on Antioxidant Activity and Carbohydrate Digestion Enzymes	21
Punicalagin Restricts Growth, Promotes Apoptosis, and Reduces Invasion in Human Gastric Cancer Cells	20
Feasibility of Enhancing Skin Permeability of Acyclovir through Sterile Topical Lyophilized Wafer on Self-Dissolving Microneedle-Treated Skin	18
Fabrication, Properties, and Stability of Oregano Essential Oil and Sodium Alginate-Based Wound-Healing Hydrogels	17
Dose Dependent Effects of Aqueous Extract of Garcinia cambogia Desr. Against Letrozole Induced Polycystic Ovarian Syndrome in Female Adult Rats With Possible Mechanisms Exploration	17
Influence of Age, Gender and Body Mass Index on Intravenous Pharmacokinetics of Buprenorphine in Children Undergoing Orthopedic Surgery	17
Smoke Screen to Distract From Flawed Science: A Response to Côté et al. Over Criticisms to Their Deficient ‘Rapid Review’ on Chiropractic X-Ray Utility	16
Expressivity of Interleukin-8 and Gastric Cancer Prognosis Susceptibility: A Systematic Review and Meta-Analysis	16
Stereotactic Body Radiotherapy and Conventional Radiotherapy Induce Cytoskeleton Extension and Enlargement of Cell Morphology in Non-Small Cell Lung Cancer	16
Radiography and Clinical Decision-Making in Chiropractic	16
Biochemical Stress Markers, Antioxidants, and Infectious Wound-Healing Potential of UV Irradiation and Salt Stress Effects on the Pre-Treated Seed of Bitter Melon (Momordica charantia L.)	15
Effects of Hawthorn Fruit Extract Drink in Chinese Patients With Mild Hypertension and/or Hyperlipidaemia: A Randomized, Double-Blind, Placebo-Controlled, Crossover Study	15
Phytochemical, Antioxidant, Toxicological, and Pharmaceutical Evaluation of Polyherbal Formulation: Irochel	14
Low-Dose Radiation Reduces Doxorubicin-Induced Myocardial Injury Through Mitochondrial Pathways	14
Scutellarin Inhibits Glioblastoma Growth in a Dose-dependent Manner by Suppressing the p63 Signaling Pathway	13

Potential Effects of Boldine on Oxidative Stress, Apoptosis, and Inflammatory Changes Induced by the Methylprednisolone Hepatotoxicity in Male Wistar Rats	13
Salidroside Protects Against Influenza A Virus-Induced Acute Lung Injury in Mice	13
Tunisian Horehound (Marrubium vulgare) Aqueous Extract Improves Treatment of Bleomycin-Induced Lung Fibrosis in Rat	13
Investigating Dual-Energy CT Post-Contrast Phases for Liver Iron Quantification: A Preliminary Study	13
Evaluation of Renessans (Iodine Complex Molecule) Safety in Human Beings: An Open-Labeled Clinical Study	13
Dose-dependent Spasmolytic, Bronchodilator, and Hypotensive Activities of Panicum miliaceum L.	13
Building Blocks Towards a Proportionate Chemicals Policy With a Focus on the Netherlands	12
Hepatoprotective Effects ofHeracleum candicansAgainst Carbon Tetrachloride-Induced Acute Liver Injury in Rats	12
Anti-Obesity Actions of Two Separated Aqueous Extracts From Arbutus (Arbutus unedo) and Hawthorn (Crataegus monogyna) Fruits Against High-Fat Diet in Rats via Potent Antioxidant Target	12
INWORKS and Hiroshima/Nagasaki Leukaemia Results	12
Green Lead Nanoparticles Induced Apoptosis and Cytotoxicity in MDA-MB-231 Cells by Inducing Reactive Oxygen Species and Caspase 3/7 Enzymes	12
Retraction Notice: “Human Brain–Derived Neurotrophic Factor Gene-Modified Bone Marrow Mesenchymal Stem Cells Combined With Erythropoietin Can Improve Acute Spinal Cord Injury”	12
The Potential Protective Effect of Curcumin and α-Lipoic Acid on N-(4-Hydroxyphenyl) Acetamide-induced Hepatotoxicity Through Downregulation of α-SMA and Collagen III Expression	12
Highly Diluted Antibodies to eNOS Restore Endothelium Function in Aortic Rings From Hypertensive Rats	11
Nano-Curcumin Protects Against Sodium Nitrite–Induced Lung Hypoxia Through Modulation of Mitogen-Activated Protein Kinases/c-Jun NH2-Terminal Kinase Signaling Pathway	11
Identification of Ascorbic Acid and Gallic Acid as Novel Inhibitors of Secreted Frizzled-Related Protein for the Treatment of Obesity-Induced Type 2 Diabetes	10
SR-5, the specific ratio of Korean multi-herbal formula: An evaluation of antiulcerogenic effects on experimentally induced gastric ulcers in mice	10
Removal of Amoxicillin From Wastewater Onto Activated Carbon: Optimization of Analytical Parameters by Response Surface Methodology	10
The Competitive Absorption by the Gut Microbiome Suggests the First-Order Absorption Kinetics of Caffeine	9
Evaluation of Cyto - and Genotoxic Influence of Lanthanum Dioxide Nanoparticles on Human Liver Cells	9
Radiation Response of Human Leukemia/Lymphoma Cells was Improved by 7-Geranyloxycoumarin	9
Pharmacological Evaluation of Mentha piperita Against Urolithiasis: An In Vitro and In Vivo Study	9
Open Letter to the President of the National Academy of Sciences	9
J-Shaped Association Between Respiratory Rate and In-Hospital Mortality in Acute Myocardial Infarction Patients Complicated by Congestive Heart Failure in Intensive Care Unit	9
Phytochemicals That Interfere With Drug Metabolism and Transport, Modifying Plasma Concentration in Humans and Animals	9
A Universal Delayed Difference Model Fitting Dose-response Curves	9
Baricitinib is Effective in Treating Progressing Vitiligo in vivo and in vitro	9
Diallyl Disulfide Attenuates Ionizing Radiation-Induced Migration and Invasion by Suppressing Nrf2 Signaling in Non–small-Cell Lung Cancer	9
Hematological Changes Following Low Dose Radiation Therapy and Comparison to Current Standard of Care Cancer Treatments	9
Antiproliferative Activities of Acetone Extract From Canarium Odontophyllum (Dabai) Stem Bark Against Human Colorectal Cancer Cells	8
Protective Effects of Polydatin on Reproductive Injury Induced by Ionizing Radiation	8
Evaluation of Brown Micro-Algae Synergies With Low Doseγ-Radiation Against Chronic Hepatitis Induced by D-Galactosamine in Rats	8
Anticancer L-Asparaginase and Phytoactive Compounds From Plant Solanum nigrum Against MDR (Methicillindrug resistant) Staphylococcus aureus and Fungal Isolates	8
Poly Lactic-Co-Glycolic Acid Nano-Carriers for Encapsulation and Controlled Release of Hydrophobic Drug to Enhance the Bioavailability and Antimicrobial Properties	8
Green Synthesis of Silver Nanoparticles (AgNPs), Structural Characterization, and their Antibacterial Potential	8
Decrease of Prolylcarboxypeptidase Dose of Aqueous Humor is Involved in the Pathogenesis of Primary Open-Angle Glaucoma via Finetuning of the Local Ocular Renin-Angiotensin System	8
Are Assigned Low-Dose-Radiation Cancer Risks Based on Some Epidemiologic Studies Unreliable?	8
The Effect of α-lipoic Acid on C-Reactive Protein Level: A Meta-analysis of Randomized, Double-Blind, and Placebo-Controlled Studies	8
Biosorptive Potential of Pseudomonas species RY12 Toward Zinc Heavy Metal in Agriculture Soil Irrigated with Contaminated Waste Water	8
Poor Uncorrected Visual Acuity and Association With Sleep Duration and Screen Time: A Dose–Response Relationship Study	8
Hormesis Research in China Is More Prevalent than Previously Thought	7
Preliminary Study on the Effect of 4DCT-Ventilation-Weighted Dose on the Radiation Induced Pneumonia Probability (RIPP)	7
Hyperbaric Oxygen Therapy-Induced Molecular and Pathway Changes in a Rat Model of Spinal Cord Injury: A Proteomic Analysis	7
Biochemical Toxic Response of Phosphine on Human Health Estimated From Enzymatic Variance in Trogoderma granarium	7
Recovery of E. coli From Liver and Spleen of Broiler Birds and the Effects of Induced High Ammonia Level on Haematobiochemical Parameters and Its Amelioration by Different Modifiers	6
Extraction and Optimization of Active Metabolites From Cluster Bean: An In Vitro Biological and Phytochemical Investigation	6
Integrative Analysis for the Roles of lncRNAs in the Immune Responses of Mouse Peripheral Blood Mononuclear Cell Exposed to Low-Dose Ionizing Radiation-Reply	6
The Hepatoprotective and Anti-Nephrotoxic Potential of Methanolic Extract of a Polyherbal Preparation in CCl₄-Induced Liver Injury Model of Wistar Rats	6
Protective Effect of Trillium tschonoskii Maxim Components Against Glutamate-Induced SH-SY5Y Cells Damage Through Regulating Apoptosis	6
Development and Evaluation of pH-Responsive Pluronic F 127 Co-Poly- (Acrylic Acid) Biodegradable Nanogels for Topical Delivery of Terbinafine HCL	6

MicroRNA-146a Improved Acute Lung Injury Induced by hepatic Ischemia-reperfusion Injury by Inhibiting PRDX1	6
Apitherapy in COVID-19-Related Conjunctivitis	6
Ad Hominem Criticisms: An Old Trick to Discredit Inconvenient Research. A Response to Oakley et al. And the International Chiropractors Association Rapid Response Research Review Subcommittee	6
Antibiofilm and Quorum Sensing Inhibition (QSI) Potential of Lagerstroemia speciosa Leaves Extract	6
Probing Effect of 6 MeV Electron Beam Irradiation on Haemoglobin Protein Using Spectroscopic Techniques	6
Modeling Cell Survival Fraction and Other Dose-Response Relationships for Immunodeficient C.B-17 SCID Mice Exposed to 320-kV X Rays	6
Role of Olive Leaf Extract, Mesenchymal Stem Cells or Low Radiation Dose in Alleviating Hepatic Injury in Rats	6
Identification of the Constituents in Cnidii Fructus Active Against Trichomonas vaginalis Parasites	6
p53-Induced Autophagy Regulates Chemotherapy and Radiotherapy Resistance in Multidrug Resistance Cancer Cells	6
Radiation Protection of Polydatin Against Radon Exposure Injury of Epithelial Cells and Mice	6
Antimicrobial and Hepatoprotective Properties of Pods of Acacia nilotica (L.) Willd. ex Delile: In Vivo and In Silico Approaches	6
Potential Functions of the tRNA-Derived Fragment tRF-Gly-GCC Associated With Oxidative Stress in Radiation-Induced Lung Injury	6