OOIR: Observatory of International Research

Papers

(The median citation count of Current Gene Therapy is 1. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-06-01 to 2025-06-01.)

Article	Citations
A Retrospective Analysis of the Lauren Classification in the Choice of XELOX or SOX as an Adjuvant Chemotherapy for Gastric Cancer	64
Effective Combination of Single-cell Analysis and Gene Therapy	36
Gene Augmentation Techniques to Stimulate Wound Healing Process: Progress and Prospects	30
Synergizing CRISPR-Cas9 with Advanced Artificial Intelligence and Machine Learning for Precision Drug Delivery: Technological Nexus and Regulatory Insights	25
Mesenchymal Stromal Cells (MSCs): A Promising Tool for Cell-Based Angiogenic Therapy	23
Next-Generation Whole-Exome Pattern: Advanced Methods and Clinical Significance	23
DNA Vaccines to Improve Immunogenicity and Effectiveness in Cancer Vaccinations: Advancement and Developments	21
Applications of L-Arginine in Pregnancy and Beyond: An Emerging Pharmacogenomic Approach	20
Acknowledgements to Reviewers	20
Identification and Validation of Amino Acid Metabolism-Related Biomarkers and Investigation of their Potential Mechanisms in Lung Adenocarcinoma	19
MDAlmc: A Novel Low-rank Matrix Completion Model for MiRNADisease Association Prediction by Integrating Similarities among MiRNAs and Diseases	18
Therapeutic Potential of POU3F3, a Novel Long Non-coding RNA, Alleviates the Pathogenesis of Osteoarthritis by Regulating the miR-29a- 3p/FOXO3 Axis	16
Comprehensive Analysis and Experimental Validation of HEPACAM2 as a Potential Prognosis Biomarker and Immunotherapy Target in Colorectal Cancer	16
In Situ Gene Therapy	16
TRPM8 as a Potential Biomarker and Therapeutic Target for Gastric Cancer Identified by a Combination of Text Mining and RNA Sequencing	15
The Role of Myeloid-derived Suppressor Cells and Non-tumor Cells in the Glioma Microenvironment	14
Gene Therapy Based on Lipid Nanoparticles as Non-viral Vectors for Glioma Treatment	14
Single-cell RNA Sequencing Analysis Identifies Key Genes in Brain Metastasis from Lung Adenocarcinoma	14
Human Virus-Like Proteins: Implications for Gene Therapy	13
Significance of Ribonucleoside-diphosphate Reductase Subunit M2 in Lung Adenocarcinoma	12
A Complete Sojourn of Gene Therapy along with its Targeting Approaches for the Treatment of the Major Depressive Disorder	12
Anesthesia and Cancer: Something More than Avoiding Stress Response	12
From DNA Editing to RNA Regulation: The Breakthroughs of CRISPR and Mega-CRISPR	12
Probing the Depths of Molecular Complexity: STAT3 as a Key Architect in Colorectal Cancer Pathogenesis	11
Role of Long Non-Coding RNA in Regulating ER Stress Response to the Progression of Diabetic Complications	11

A Hypoxia-Regulated Retinal Pigment Epithelium-Specific Gene Therapy Vector Reduces Choroidal Neovascularization in a Mouse Model	10
Corrigendum to: Neuroprotection by Human Dental Pulp Mesenchymal Stem Cells: From Billions to Nano	10
Lentiviral Micro-dystrophin Gene Treatment into Late-stage mdx Mice for Duchenne Muscular Dystrophy Disease	10
Therapeutic Effects of Mesenchymal Stem Cells Expressing Erythropoietin on Cancer-Related Anemia in Mice Model	9
Gene Therapy & Cell Therapy	9
HCST Expression Distinguishes Immune-hot and Immune-cold Subtypes in Pancreatic Ductal Adenocarcinoma	8
Hemophilia Healing with AAV: Navigating the Frontier of Gene Therapy	8
Splicing DNA Damage Adaptations for the Management of Cancer Cells	8
Biogenesis and Function of circRNAs in Pulmonary Fibrosis	8
Gene Therapy for Chronic Traumatic Brain Injury: Challenges in Resolving Long-term Consequences of Brain Damage	8
Effect of Bovine Lactoferrin Treatment on Iron Homeostasis and Gene Expression Changes in Multiple Organ Dysfunctions During Wound Healing Process in Rats	8
Reduced Immunogenicity of Intraparenchymal Delivery of Adeno-Associated Virus Serotype 2 Vectors: Brief Overview	8
Mechanism of CAV and CAVIN Family Genes in Acute Lung Injury based on DeepGENE	8
Gene Therapy for Rare Genetic Diseases	7
Prediction of SARS-CoV-2 Infection Phosphorylation Sites and Associations of these Modifications with Lung Cancer Development	7
Non-coding RNAs in Regulation of Protein Aggregation and Clearance Pathways: Current Perspectives Towards Alzheimer's Research and Therapy	7
CRISPR/Cas9 Technology for Modifying Immune Checkpoint in CAR-T Cell Therapy for Hematopoietic Malignancies	6
Efficacy of Gene Therapy to Restore Cognition in Alzheimer’s Disease: A Systematic Review	6
Computational Analysis Illustrates the Mechanism of Qingfei Paidu Decoction in Blocking the Transition of COVID-19 Patients from Mild to Severe Stage	6
Untangling the Genetic Threads of Alzheimer's: Insights into Risk Factors and Biomarkers	6
Pan-Cancer Single-Cell Analysis Revealing the Heterogeneity of Cancer-Associated Fibroblasts in Skin Tumors	6
Segmentation of Thoracic Organs through Distributed Extraction of Visual Feature Patterns Utilizing Resio-Inception U-Net and Deep Cluster Recognition Techniques	6
Dissecting the Mechanisms of Intestinal Immune Homeostasis by Analyzing T-Cell Immune Response in Crohn's Disease and Colorectal Cancer	6
Single-cell and Bulk Transcriptomic Analyses Reveal a Stemness and Circadian Rhythm Disturbance-related Signature Predicting Clinical Outcome and Immunotherapy Response in Hepatocellular Carcinoma	6
Current Updates on the Role of MicroRNA in the Diagnosis and Treatment of Neurodegenerative Diseases	5
Targeting of Ykl-40 as a Protumor in Personalized Medicine: A New Dimension in Disease Understanding	5
Hereditary Patterns and Genetic Associations in Obsessive-Compulsive Disorder (OCD): Neuropsychiatric Insights, Genetic Influences, and Treatment Perspectives	5
Efficacy and Safety of Pembrolizumab Monotherapy or Combined Therapy in Patients with Metastatic Triple-negative Breast Cancer: A Systematic Review and Meta-Analysis of Randomized Controlled Trials	5
Knockdown of hsa_circ_0102231 Impedes the Progression of Liver Cancer through the miR-873–SOX4 Axis	5
Targeting Extrachromosomal DNA (ecDNA) in Cancer: A New Era of CHK1 Inhibition and Personalized Treatments	5
AEG-1 as a Novel Therapeutic Target in Colon Cancer: A Study from Silencing AEG-1 in BALB/c Mice to Large Data Analysis	5
Acknowledgements to Reviewers	4
Reversal of Neuropsychiatric Comorbidities in an Animal Model of Temporal Lobe Epilepsy Following Systemic Administration of Dental Pulp Stem Cells and Bone Marrow Mesenchymal Stem Cells	4
The Role of Immunotherapy in Lung Cancer Treatment: Current Strategies, Future Directions, and Insights into Metastasis and Immune Microenvironment	4
MicroRNAs: A Critical Regulator and a Promising Therapeutic and Diagnostic Molecule for Diabetic Cardiomyopathy	4
FIGNL1 Promotes Hepatocellular Carcinoma Formation via Remodeling ECM-receptor Interaction Pathway Mediated by HMMR	4
Immune Modulation Strategies in Gene Therapy: Overcoming Immune Barriers and Enhancing Efficacy	4
Single Injection AAV2-FGF18 Gene Therapy Reduces Cartilage Loss and Subchondral Bone Damage in a Mechanically Induced Model of Osteoarthritis	4
CRISPR-Cas9: Transforming Functional Genomics, Precision Medicine, and Drug Development – Opportunities, Challenges, and Future Directions	4
The Role of RNA m6A Modification in Cancer Glycolytic Reprogramming	4
CRISPR/Cas System: A Powerful Strategy to Improve Monogenic Human Diseases as Therapeutic Delivery; Current Applications and Challenges	4
A Quest to the Therapeutic Arsenal: Novel Strategies to Combat Multidrug- resistant Bacteria	3
Neurotrophins as Potential Gene Therapy Targets for Huntington's Disease	3
Recent Advances in CRISPR/Cas9 Directed Base Editing	3
Effective Downregulation of BCR-ABL Tumorigenicity by RNA Targeted CRISPR-Cas13a	3
Current Landscape and Emerging Opportunities of Gene Therapy with Non-viral Episomal Vectors	3
Target and Gene-Based Therapeutic Strategies against Pancreatic Cancer: Current and Future Prospects	3
Mammalian Stable Cell Platforms for Recombinant Adeno-associated Virus (rAAV) Production: Development Strategies and their Impact on Viral Productivity	3
Gene Therapy for Skin Aging	3
Identification of Chronic Hypersensitivity Pneumonitis Biomarkers with Machine Learning and Differential Co-expression Analysis	3

Exploring Genetic and Receptor-Based Dopaminergic Strategies for Antidepressant Drug Development	3
Targeting Undruggable Proteins: The siRNA Revolution Beyond Small Molecules - Advances, Challenges, and Future Prospects in Therapeutic Innovation	3
Unraveling Glioblastoma: TME Implication and Gene Therapy Advances	3
Recent Advances in Predicting Protein-lncRNA Interactions Using Machine Learning Methods	3
Clinical Development of Cell Therapies to Halt Lysosomal Storage Diseases: Results and Lessons Learned	3
Predicting LncRNA-Disease Association Based on Generative Adversarial Network	2
siRNA Knocking Down in HepG2 Cells Identifies PFKFB4 and HNF4α as Key Genes Important for Cancer Cell Survival	2
Meet the Editorial Board Member	2
Development of Cell and Gene Therapies for Clinical Use in the US and EU: Summary of Regulatory Guidelines	2
Implications of EBV-Encoded and EBV-Related miRNAs in Tumors	2
miRNA-1260b Promotes Breast Cancer Cell Migration and Invasion by Downregulating CCDC134	2
Prospects of Non-Coding Elements in Genomic DNA Based Gene Therapy	2
Catechin Protects against Lipopolysaccharide-induced Depressive-like Behaviour in Mice by Regulating Neuronal and Inflammatory Genes	2
Polysaccharide-Based Delivery Systems for CRISPR/Cas Gene Therapy: Overcoming Challenges and Advancing Pharmaceutical Solutions	2
Development of Lentiviral Packaging Cells and Scale Up of Production to Meet the Growing Demand in Cell and Gene Therapy	2
Duchenne Muscular Dystrophy Gene Therapy	1
Inferring Cell-type-specific Genes of Lung Cancer Based on Deep Learning	1
Acknowledgements to Reviewers	1
Hutchinson-Gilford Progeria Syndrome: An Overview of the Molecular Mechanism, Pathophysiology and Therapeutic Approach	1
Identification and Analysis of RNA Editing Events in Ovarian Serous Cystadenoma Using RNA-seq Data	1
Cancer Treatment Evolution from Traditional Methods to Stem Cells and Gene Therapy	1
High-Throughput Sequencing Reveals N6-Methyladenosine-modified LncRNAs as Potential Biomarkers in Mice with Liver Fibrosis	1
The Effectiveness of Nanoparticles on Gene Therapy for Glioblastoma Cells Apoptosis: A Systematic Review	1
Transforming RNA-Based Gene Therapy with Innovative Nanocarriers for siRNA and miRNA Delivery	1
Characteristics of Oxidative Phosphorylation-Related Subtypes and Construction of a Prognostic Signature in Ovarian Cancer	1
Advancements in CRISPR-Based Therapies for Genetic Modulation in Neurodegenerative Disorders	1
miRNA-Targeted Vaccines: A Promising Approach for Viral Attenuation and Immunogenicity Enhancement	1
Gene Therapy Cargoes Based on Viral Vector Delivery	1
Proteomic Analyses Reveal Functional Pathways and Potential Targets in Pediatric Hydrocephalus	1
Next-Generation Nucleic Acid Delivery: A Review of Nanobiosystem Design and Applications	1
Therapeutic Potential of CRISPR/Cas in Hashimoto's Thyroiditis: A Comprehensive Review	1
ZNF695, A Potential Prognostic Biomarker, Correlates with Im mune Infiltrates in Cervical Squamous Cell Carcinoma and Endoce rvical Adenocarcinoma: Bioinformatic Analysis and Experimental Verification	1
Meet the Editorial Board Member	1
Poly(rC) Binding Protein 1 Represses the Translation of STAT3 through 5' UTR	1
Gene Therapy of Mucopolysaccharidosis Type I Mice: Repeated Administrations and Safety Assessment of pIDUA/Nanoemulsion Complexes	1
Plasmalogens Activate AKT/mTOR Signaling to Attenuate Reactive Oxygen Species Production in Spinal Cord Injury	1
Expression of miR-92a in Green Tea EGCG Preconditioned Adiposederived Stem Cells Ameliorates Inflammatory Response and Increases Cartilage Regeneration in RA Rats through KLF4/IL-17/MMP-2 Axis Modulat	1
SHR6390 Combined with Cabozantinib Inhibits Tumor Progression in the Hepatocellular Carcinoma Mouse Model	1
Identification of the Metabolic Characteristic of Organ Fibrosis Using Microbial Analysis on RNA-seq Data	1