OOIR: Observatory of International Research

Papers

(The median citation count of Current Gene Therapy is 2. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2022-01-01 to 2026-01-01.)

Article	Citations
Effective Combination of Single-cell Analysis and Gene Therapy	79
Synergizing CRISPR-Cas9 with Advanced Artificial Intelligence and Machine Learning for Precision Drug Delivery: Technological Nexus and Regulatory Insights	39
A Comprehensive Review of Genetic Risk Factors for Alzheimer’s Disease Development	36
Gene Augmentation Techniques to Stimulate Wound Healing Process: Progress and Prospects	30
Identifying ARRB2 as a Prognostic Biomarker and Key Player in the Tumor Microenvironment of Pancreatic Cancer through scPagwas Methodology	30
Next-Generation Whole-Exome Pattern: Advanced Methods and ClinicalSignificance	26
A Retrospective Analysis of the Lauren Classification in the Choice of XELOX or SOX as an Adjuvant Chemotherapy for Gastric Cancer	22
Identifying Key Epigenetic Modification-Related Genes for Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma and Cellular Validation	22
Acknowledgements to Reviewers	21
Applications of L-Arginine in Pregnancy and Beyond: An Emerging Pharmacogenomic Approach	20
Identification and Validation of Amino Acid Metabolism-Related Biomarkers and Investigation of their Potential Mechanisms in Lung Adenocarcinoma	19
DNA Vaccines to Improve Immunogenicity and Effectiveness in Cancer Vaccinations: Advancement and Developments	19
MDAlmc: A Novel Low-rank Matrix Completion Model for MiRNADisease Association Prediction by Integrating Similarities among MiRNAs and Diseases	19
Therapeutic Potential of POU3F3, a Novel Long Non-coding RNA, Alleviates the Pathogenesis of Osteoarthritis by Regulating the miR-29a- 3p/FOXO3 Axis	17
Comprehensive Analysis and Experimental Validation of HEPACAM2 as a Potential Prognosis Biomarker and Immunotherapy Target in Colorectal Cancer	16
The Role of Myeloid-derived Suppressor Cells and Non-tumor Cells in theGlioma Microenvironment	15
Human Virus-Like Proteins: Implications for Gene Therapy	15
Harnessing Nanotechnology and Gene Editing for Cancer Therapy: ASynergistic Approach to Precision Medicine	13
TRPM8 as a Potential Biomarker and Therapeutic Target for Gastric Cancer Identified by a Combination of Text Mining and RNA Sequencing	13
A Complete Sojourn of Gene Therapy along with its Targeting Approaches for the Treatment of the Major Depressive Disorder	12
Anesthesia and Cancer: Something More than Avoiding Stress Response	11
Significance of Ribonucleoside-diphosphate Reductase Subunit M2 in Lung Adenocarcinoma	11
From DNA Editing to RNA Regulation: The Breakthroughs of CRISPR and Mega-CRISPR	11
Role of Long Non-Coding RNA in Regulating ER Stress Response to the Progression of Diabetic Complications	10
A Hypoxia-Regulated Retinal Pigment Epithelium-Specific Gene Therapy Vector Reduces Choroidal Neovascularization in a Mouse Model	10

Corrigendum to: Neuroprotection by Human Dental Pulp Mesenchymal Stem Cells: From Billions to Nano	10
Therapeutic Effects of Mesenchymal Stem Cells Carrying Echovirus inMouse Models of Breast Cancer	10
Probing the Depths of Molecular Complexity: STAT3 as a Key Architect in Colorectal Cancer Pathogenesis	10
Lentiviral Micro-dystrophin Gene Treatment into Late-stage mdx Mice for Duchenne Muscular Dystrophy Disease	10
Therapeutic Effects of Mesenchymal Stem Cells Expressing Erythropoietin on Cancer-Related Anemia in Mice Model	10
Mechanism of CAV and CAVIN Family Genes in Acute Lung Injury based on DeepGENE	9
The Mitochondrial Deoxyribonucleic Acid Puzzle: Controversies, Challenges, and Critical Perspectives A Narrative Review	9
Effect of Bovine Lactoferrin Treatment on Iron Homeostasis and Gene Expression Changes in Multiple Organ Dysfunctions During Wound Healing Process in Rats	9
Revolution of Traditional Chinese Medicine in Anticancer Therapy, Applications and Future Perspective	9
Hemophilia Healing with AAV: Navigating the Frontier of Gene Therapy	8
Gene Therapy for Chronic Traumatic Brain Injury: Challenges in Resolving Long-term Consequences of Brain Damage	8
Reduced Immunogenicity of Intraparenchymal Delivery of Adeno-Associated Virus Serotype 2 Vectors: Brief Overview	8
Gene Therapy for Rare Genetic Diseases	8
Splicing DNA Damage Adaptations for the Management of Cancer Cells	8
Synergistic Antiproliferative Effects of EGCG and Myricetin on Cervical Cancer Biomarkers in ME180 and SiHa Cell Lines	8
Segmentation of Thoracic Organs through Distributed Extraction of Visual Feature Patterns Utilizing Resio-Inception U-Net and Deep Cluster Recognition Techniques	7
Computational Analysis Illustrates the Mechanism of Qingfei Paidu Decoction in Blocking the Transition of COVID-19 Patients from Mild to Severe Stage	7
Role of Exosomal miRNAs and Epigenetic Modifications in Diabetic Nephropathy: Insights into Novel Diagnostic and Therapeutic Strategies	7
Non-coding RNAs in Regulation of Protein Aggregation and Clearance Pathways: Current Perspectives Towards Alzheimer's Research and Therapy	7
A Paradigm Shift in Hemophilia Care: The Promise of Gene Therapy	7
HCST Expression Distinguishes Immune-hot and Immune-cold Subtypes in Pancreatic Ductal Adenocarcinoma	7
Pan-Cancer Single-Cell Analysis Revealing the Heterogeneity of Cancer- Associated Fibroblasts in Skin Tumors	7
A Comprehensive Review on Human Metapneumovirus	7
Prediction of SARS-CoV-2 Infection Phosphorylation Sites and Associations of these Modifications with Lung Cancer Development	7
Single-cell and Bulk Transcriptomic Analyses Reveal a Stemness and Circadian Rhythm Disturbance-related Signature Predicting Clinical Outcome and Immunotherapy Response in Hepatocellular Carcinoma	7
Dissecting the Mechanisms of Intestinal Immune Homeostasis by Analyzing T-Cell Immune Response in Crohn's Disease and Colorectal Cancer	6
Biogenesis and Function of circRNAs in Pulmonary Fibrosis	6
Immunoinformatic Based Designing of Immune Boosting and Nonallergenic Multi-epitope Subunit Vaccine Against the Enterovirus D68	6
Targeting Extrachromosomal DNA (ecDNA) in Cancer: A New Era ofCHK1 Inhibition and Personalized Treatments	6
Untangling the Genetic Threads of Alzheimer's: Insights into Risk Factors and Biomarkers	6
Unraveling Etiological Indications and Therapeutic Implications of Familial Cerebral Cavernous Malformations in the Dawn of Gene Therapy for Monogenic Conditions	6
Precision Medicine: Design of Immune Inert Exosomes for Targeted Gene Delivery	6
Novel Perspective of Regulating P53/Bcl2/Caspase-3 via In vitro Targeted AFP Gene Knocks Out in HepG2 Cells Using CRISPR/Cas9 Editing Tool	6
Targeted Therapies and Computational Approaches in the Management of Crohn's Disease	5
Current Updates on the Role of MicroRNA in the Diagnosis and Treatment of Neurodegenerative Diseases	5
Transcriptomic Signatures in TP53 Positive and Negative Tumor Samplesin NSCLC	5
Single Injection AAV2-FGF18 Gene Therapy Reduces Cartilage Loss and Subchondral Bone Damage in a Mechanically Induced Model of Osteoarthritis	5
CRISPR/Cas9 Technology for Modifying Immune Checkpoint in CAR-T Cell Therapy for Hematopoietic Malignancies	5
Targeting of Ykl-40 as a Protumor in Personalized Medicine: A New Dimension in Disease Understanding	5
Hereditary Patterns and Genetic Associations in Obsessive-Compulsive Disorder (OCD): Neuropsychiatric Insights, Genetic Influences, and Treatment Perspectives	5
Knockdown of hsa_circ_0102231 Impedes the Progression of Liver Cancer through the miR-873–SOX4 Axis	5
The Role of RNA m6A Modification in Cancer Glycolytic Reprogramming	4
AEG-1 as a Novel Therapeutic Target in Colon Cancer: A Study from Silencing AEG-1 in BALB/c Mice to Large Data Analysis	4
Review Deciphering the Anticancer Efficacy of Oroxylin A Targeting Dysregulated Oncogenes	4
Gene Therapy for Skin Aging	4
Current Landscape and Emerging Opportunities of Gene Therapy with Non-viral Episomal Vectors	4
Acknowledgements to Reviewers	4
The Role of Immunotherapy in Lung Cancer Treatment: Current Strategies, Future Directions, and Insights into Metastasis and Immune Microenvironment	4
CRISPR/Cas System: A Powerful Strategy to Improve Monogenic Human Diseases as Therapeutic Delivery; Current Applications and Challenges	4
Efficacy and Safety of Pembrolizumab Monotherapy or Combined Therapy in Patients with Metastatic Triple-negative Breast Cancer: A Systematic Review and Meta-Analysis of Randomized Controlled Trials	4

FIGNL1 Promotes Hepatocellular Carcinoma Formation via Remodeling ECM-receptor Interaction Pathway Mediated by HMMR	4
Clinical Development of Cell Therapies to Halt Lysosomal Storage Diseases: Results and Lessons Learned	4
Machine Learning-Driven PCDI Classifier for Invasive PitNETs	4
Immune Modulation Strategies in Gene Therapy: Overcoming Immune Barriers and Enhancing Efficacy	4
Recent Advances in Predicting Protein-lncRNA Interactions Using Machine Learning Methods	4
Reversal of Neuropsychiatric Comorbidities in an Animal Model of Temporal Lobe Epilepsy Following Systemic Administration of Dental Pulp Stem Cells and Bone Marrow Mesenchymal Stem Cells	4
CRISPR-Cas9: Transforming Functional Genomics, Precision Medicine,and Drug Development Opportunities, Challenges, and Future Directions	4
Exploring Genetic and Receptor-Based Dopaminergic Strategies for Antidepressant Drug Development	4
Neurotrophins as Potential Gene Therapy Targets for Huntington's Disease	4
Predicting LncRNA-Disease Association Based on Generative Adversarial Network	3
Target and Gene-Based Therapeutic Strategies against Pancreatic Cancer: Current and Future Prospects	3
Unraveling Glioblastoma: TME Implication and Gene Therapy Advances	3
miRNA-1260b Promotes Breast Cancer Cell Migration and Invasion by Downregulating CCDC134	3
Mammalian Stable Cell Platforms for Recombinant Adeno-associated Virus (rAAV) Production: Development Strategies and their Impact on Viral Productivity	3
A Quest to the Therapeutic Arsenal: Novel Strategies to Combat Multidrug- resistant Bacteria	3
Development of Lentiviral Packaging Cells and Scale Up of Production to Meet the Growing Demand in Cell and Gene Therapy	3
Targeting Undruggable Proteins: The siRNA Revolution Beyond SmallMolecules - Advances, Challenges, and Future Prospects in TherapeuticInnovation	3
Prospects of Non-Coding Elements in Genomic DNA Based Gene Therapy	3
Tailored Therapies for Hereditary Diabetes: Unraveling the Genetic Underpinnings of MODY and Neonatal Diabetes	3
Catechin Protects against Lipopolysaccharide-induced Depressive-like Behaviour in Mice by Regulating Neuronal and Inflammatory Genes	2
siRNA Knocking Down in HepG2 Cells Identifies PFKFB4 and HNF4α as Key Genes Important for Cancer Cell Survival	2
Development of Cell and Gene Therapies for Clinical Use in the US and EU: Summary of Regulatory Guidelines	2
5-Alpha Reductase Deficiency - An Uncommon Disorder of Sexual Development: A Case Study of Four Turkish Patients within a Family	2
Advancing Antibacterial Strategies: CRISPR-Phage-Mediated Gene Therapy Targeting Bacterial Resistance Genes	2
ZNF695, A Potential Prognostic Biomarker, Correlates with Im mune Infiltrates in Cervical Squamous Cell Carcinoma and Endoce rvical Adenocarcinoma: Bioinformatic Analysis and Experimental Verification	2
Plasmalogens Activate AKT/mTOR Signaling to Attenuate Reactive Oxygen Species Production in Spinal Cord Injury	2
Implications of EBV-Encoded and EBV-Related miRNAs in Tumors	2
Polysaccharide-Based Delivery Systems for CRISPR/Cas Gene Therapy:Overcoming Challenges and Advancing Pharmaceutical Solutions	2
Advancements in CRISPR-Based Therapies for Genetic Modulation in Neurodegenerative Disorders	2
Transforming RNA-Based Gene Therapy with Innovative Nanocarriersfor siRNA and miRNA Delivery	2
Inferring Cell-type-specific Genes of Lung Cancer Based on Deep Learning	2
Characteristics of Oxidative Phosphorylation-Related Subtypes and Construction of a Prognostic Signature in Ovarian Cancer	2
Identification of Novel Biomarkers of Bacterial Lipopolysaccharides in Diabetic Nephropathy via Transcriptomics and Mendelian Randomization	2
Poly(rC) Binding Protein 1 Represses the Translation of STAT3 through 5' UTR	2
miRNA-Targeted Vaccines: A Promising Approach for Viral Attenuation and Immunogenicity Enhancement	2
Preface-2026	2
Meet the Editorial Board Member	2
Duchenne Muscular Dystrophy Gene Therapy	2
Gene Therapy Cargoes Based on Viral Vector Delivery	2
Attenuated Salmonella Carrying IL-21-siRNA-CCR2 Co-expression Plasmid Enhances Anti-tumor Immune Response in Lung Cancer-bearing Mice	2
Meet the Editorial Board Member	2