OOIR: Observatory of International Research

Papers

(The median citation count of Current Gene Therapy is 1. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-11-01 to 2025-11-01.)

Article	Citations
Effective Combination of Single-cell Analysis and Gene Therapy	75
A Retrospective Analysis of the Lauren Classification in the Choice of XELOX or SOX as an Adjuvant Chemotherapy for Gastric Cancer	39
Synergizing CRISPR-Cas9 with Advanced Artificial Intelligence and Machine Learning for Precision Drug Delivery: Technological Nexus and Regulatory Insights	32
A Comprehensive Review of Genetic Risk Factors for Alzheimer’s Disease Development	30
Identifying ARRB2 as a Prognostic Biomarker and Key Player in the Tumor Microenvironment of Pancreatic Cancer through scPagwas Methodology	27
Gene Augmentation Techniques to Stimulate Wound Healing Process: Progress and Prospects	25
Next-Generation Whole-Exome Pattern: Advanced Methods and ClinicalSignificance	23
Acknowledgements to Reviewers	20
DNA Vaccines to Improve Immunogenicity and Effectiveness in Cancer Vaccinations: Advancement and Developments	20
Mesenchymal Stromal Cells (MSCs): A Promising Tool for Cell-Based Angiogenic Therapy	20
Therapeutic Potential of POU3F3, a Novel Long Non-coding RNA, Alleviates the Pathogenesis of Osteoarthritis by Regulating the miR-29a- 3p/FOXO3 Axis	18
MDAlmc: A Novel Low-rank Matrix Completion Model for MiRNADisease Association Prediction by Integrating Similarities among MiRNAs and Diseases	18
Applications of L-Arginine in Pregnancy and Beyond: An Emerging Pharmacogenomic Approach	18
Comprehensive Analysis and Experimental Validation of HEPACAM2 as a Potential Prognosis Biomarker and Immunotherapy Target in Colorectal Cancer	16
In Situ Gene Therapy	16
Identification and Validation of Amino Acid Metabolism-Related Biomarkers and Investigation of their Potential Mechanisms in Lung Adenocarcinoma	13
Harnessing Nanotechnology and Gene Editing for Cancer Therapy: ASynergistic Approach to Precision Medicine	12
Human Virus-Like Proteins: Implications for Gene Therapy	12
The Role of Myeloid-derived Suppressor Cells and Non-tumor Cells in theGlioma Microenvironment	12
A Complete Sojourn of Gene Therapy along with its Targeting Approaches for the Treatment of the Major Depressive Disorder	11
TRPM8 as a Potential Biomarker and Therapeutic Target for Gastric Cancer Identified by a Combination of Text Mining and RNA Sequencing	11
Gene Therapy Based on Lipid Nanoparticles as Non-viral Vectors for Glioma Treatment	11
Anesthesia and Cancer: Something More than Avoiding Stress Response	10
Probing the Depths of Molecular Complexity: STAT3 as a Key Architect in Colorectal Cancer Pathogenesis	10
From DNA Editing to RNA Regulation: The Breakthroughs of CRISPR and Mega-CRISPR	10

Role of Long Non-Coding RNA in Regulating ER Stress Response to the Progression of Diabetic Complications	10
Significance of Ribonucleoside-diphosphate Reductase Subunit M2 in Lung Adenocarcinoma	10
Lentiviral Micro-dystrophin Gene Treatment into Late-stage mdx Mice for Duchenne Muscular Dystrophy Disease	9
Corrigendum to: Neuroprotection by Human Dental Pulp Mesenchymal Stem Cells: From Billions to Nano	9
Gene Therapy & Cell Therapy	8
Therapeutic Effects of Mesenchymal Stem Cells Expressing Erythropoietin on Cancer-Related Anemia in Mice Model	8
Therapeutic Effects of Mesenchymal Stem Cells Carrying Echovirus inMouse Models of Breast Cancer	8
Effect of Bovine Lactoferrin Treatment on Iron Homeostasis and Gene Expression Changes in Multiple Organ Dysfunctions During Wound Healing Process in Rats	8
Mechanism of CAV and CAVIN Family Genes in Acute Lung Injury based on DeepGENE	8
A Hypoxia-Regulated Retinal Pigment Epithelium-Specific Gene Therapy Vector Reduces Choroidal Neovascularization in a Mouse Model	8
Gene Therapy for Chronic Traumatic Brain Injury: Challenges in Resolving Long-term Consequences of Brain Damage	8
Reduced Immunogenicity of Intraparenchymal Delivery of Adeno-Associated Virus Serotype 2 Vectors: Brief Overview	7
Hemophilia Healing with AAV: Navigating the Frontier of Gene Therapy	7
The Mitochondrial Deoxyribonucleic Acid Puzzle: Controversies, Challenges, and Critical Perspectives A Narrative Review	7
Splicing DNA Damage Adaptations for the Management of Cancer Cells	7
HCST Expression Distinguishes Immune-hot and Immune-cold Subtypes in Pancreatic Ductal Adenocarcinoma	6
Synergistic Antiproliferative Effects of EGCG and Myricetin on Cervical Cancer Biomarkers in ME180 and SiHa Cell Lines	6
Biogenesis and Function of circRNAs in Pulmonary Fibrosis	6
Revolution of Traditional Chinese Medicine in Anticancer Therapy, Applications and Future Perspective	6
Gene Therapy for Rare Genetic Diseases	6
Non-coding RNAs in Regulation of Protein Aggregation and Clearance Pathways: Current Perspectives Towards Alzheimer's Research and Therapy	5
Single-cell and Bulk Transcriptomic Analyses Reveal a Stemness and Circadian Rhythm Disturbance-related Signature Predicting Clinical Outcome and Immunotherapy Response in Hepatocellular Carcinoma	5
Role of Exosomal miRNAs and Epigenetic Modifications in Diabetic Nephropathy: Insights into Novel Diagnostic and Therapeutic Strategies	5
Prediction of SARS-CoV-2 Infection Phosphorylation Sites and Associations of these Modifications with Lung Cancer Development	5
A Paradigm Shift in Hemophilia Care: The Promise of Gene Therapy	5
Untangling the Genetic Threads of Alzheimer's: Insights into Risk Factors and Biomarkers	5
Computational Analysis Illustrates the Mechanism of Qingfei Paidu Decoction in Blocking the Transition of COVID-19 Patients from Mild to Severe Stage	5
Pan-Cancer Single-Cell Analysis Revealing the Heterogeneity of Cancer- Associated Fibroblasts in Skin Tumors	5
Segmentation of Thoracic Organs through Distributed Extraction of Visual Feature Patterns Utilizing Resio-Inception U-Net and Deep Cluster Recognition Techniques	5
Novel Perspective of Regulating P53/Bcl2/Caspase-3 via In vitro Targeted AFP Gene Knocks Out in HepG2 Cells Using CRISPR/Cas9 Editing Tool	5
Reversal of Neuropsychiatric Comorbidities in an Animal Model of Temporal Lobe Epilepsy Following Systemic Administration of Dental Pulp Stem Cells and Bone Marrow Mesenchymal Stem Cells	4
Immunoinformatic Based Designing of Immune Boosting and Nonallergenic Multi-epitope Subunit Vaccine Against the Enterovirus D68	4
Precision Medicine: Design of Immune Inert Exosomes for Targeted Gene Delivery	4
Hereditary Patterns and Genetic Associations in Obsessive-Compulsive Disorder (OCD): Neuropsychiatric Insights, Genetic Influences, and Treatment Perspectives	4
Efficacy and Safety of Pembrolizumab Monotherapy or Combined Therapy in Patients with Metastatic Triple-negative Breast Cancer: A Systematic Review and Meta-Analysis of Randomized Controlled Trials	4
Immune Modulation Strategies in Gene Therapy: Overcoming Immune Barriers and Enhancing Efficacy	4
Targeted Therapies and Computational Approaches in the Management of Crohn's Disease	4
Current Updates on the Role of MicroRNA in the Diagnosis and Treatment of Neurodegenerative Diseases	4
Knockdown of hsa_circ_0102231 Impedes the Progression of Liver Cancer through the miR-873–SOX4 Axis	4
Transcriptomic Signatures in TP53 Positive and Negative Tumor Samplesin NSCLC	4
Unraveling Etiological Indications and Therapeutic Implications of Familial Cerebral Cavernous Malformations in the Dawn of Gene Therapy for Monogenic Conditions	4
Single Injection AAV2-FGF18 Gene Therapy Reduces Cartilage Loss and Subchondral Bone Damage in a Mechanically Induced Model of Osteoarthritis	4
The Role of RNA m6A Modification in Cancer Glycolytic Reprogramming	4
Dissecting the Mechanisms of Intestinal Immune Homeostasis by Analyzing T-Cell Immune Response in Crohn's Disease and Colorectal Cancer	4
Targeting Extrachromosomal DNA (ecDNA) in Cancer: A New Era ofCHK1 Inhibition and Personalized Treatments	4
CRISPR/Cas9 Technology for Modifying Immune Checkpoint in CAR-T Cell Therapy for Hematopoietic Malignancies	4
Targeting of Ykl-40 as a Protumor in Personalized Medicine: A New Dimension in Disease Understanding	4
AEG-1 as a Novel Therapeutic Target in Colon Cancer: A Study from Silencing AEG-1 in BALB/c Mice to Large Data Analysis	4
The Role of Immunotherapy in Lung Cancer Treatment: Current Strategies, Future Directions, and Insights into Metastasis and Immune Microenvironment	3
Review Deciphering the Anticancer Efficacy of Oroxylin A Targeting Dysregulated Oncogenes	3

Acknowledgements to Reviewers	3
CRISPR-Cas9: Transforming Functional Genomics, Precision Medicine,and Drug Development Opportunities, Challenges, and Future Directions	3
Clinical Development of Cell Therapies to Halt Lysosomal Storage Diseases: Results and Lessons Learned	3
CRISPR/Cas System: A Powerful Strategy to Improve Monogenic Human Diseases as Therapeutic Delivery; Current Applications and Challenges	3
Gene Therapy for Skin Aging	3
Current Landscape and Emerging Opportunities of Gene Therapy with Non-viral Episomal Vectors	3
Machine Learning-Driven PCDI Classifier for Invasive PitNETs	3
FIGNL1 Promotes Hepatocellular Carcinoma Formation via Remodeling ECM-receptor Interaction Pathway Mediated by HMMR	3
Exploring Genetic and Receptor-Based Dopaminergic Strategies for Antidepressant Drug Development	3
Recent Advances in Predicting Protein-lncRNA Interactions Using Machine Learning Methods	3
Target and Gene-Based Therapeutic Strategies against Pancreatic Cancer: Current and Future Prospects	3
Neurotrophins as Potential Gene Therapy Targets for Huntington's Disease	2
Predicting LncRNA-Disease Association Based on Generative Adversarial Network	2
Development of Lentiviral Packaging Cells and Scale Up of Production to Meet the Growing Demand in Cell and Gene Therapy	2
miRNA-Targeted Vaccines: A Promising Approach for Viral Attenuation and Immunogenicity Enhancement	2
Targeting Undruggable Proteins: The siRNA Revolution Beyond SmallMolecules - Advances, Challenges, and Future Prospects in TherapeuticInnovation	2
Mammalian Stable Cell Platforms for Recombinant Adeno-associated Virus (rAAV) Production: Development Strategies and their Impact on Viral Productivity	2
A Quest to the Therapeutic Arsenal: Novel Strategies to Combat Multidrug- resistant Bacteria	2
Development of Cell and Gene Therapies for Clinical Use in the US and EU: Summary of Regulatory Guidelines	2
miRNA-1260b Promotes Breast Cancer Cell Migration and Invasion by Downregulating CCDC134	2
Unraveling Glioblastoma: TME Implication and Gene Therapy Advances	2
Tailored Therapies for Hereditary Diabetes: Unraveling the Genetic Underpinnings of MODY and Neonatal Diabetes	2
Prospects of Non-Coding Elements in Genomic DNA Based Gene Therapy	2
Meet the Editorial Board Member	1
Next-Generation Nucleic Acid Delivery: A Review of Nanobiosystem Design and Applications	1
Attenuated Salmonella Carrying IL-21-siRNA-CCR2 Co-expression Plasmid Enhances Anti-tumor Immune Response in Lung Cancer-bearing Mice	1
Gene Therapy Cargoes Based on Viral Vector Delivery	1
Proteomic Analyses Reveal Functional Pathways and Potential Targets in Pediatric Hydrocephalus	1
Advancements in CRISPR-Based Therapies for Genetic Modulation in Neurodegenerative Disorders	1
Catechin Protects against Lipopolysaccharide-induced Depressive-like Behaviour in Mice by Regulating Neuronal and Inflammatory Genes	1
siRNA Knocking Down in HepG2 Cells Identifies PFKFB4 and HNF4α as Key Genes Important for Cancer Cell Survival	1
Polysaccharide-Based Delivery Systems for CRISPR/Cas Gene Therapy:Overcoming Challenges and Advancing Pharmaceutical Solutions	1
Inferring Cell-type-specific Genes of Lung Cancer Based on Deep Learning	1
Identification of Novel Biomarkers of Bacterial Lipopolysaccharides in Diabetic Nephropathy via Transcriptomics and Mendelian Randomization	1
Plasmalogens Activate AKT/mTOR Signaling to Attenuate Reactive Oxygen Species Production in Spinal Cord Injury	1
Gene Therapy of Mucopolysaccharidosis Type I Mice: Repeated Administrations and Safety Assessment of pIDUA/Nanoemulsion Complexes	1
Characteristics of Oxidative Phosphorylation-Related Subtypes and Construction of a Prognostic Signature in Ovarian Cancer	1
Poly(rC) Binding Protein 1 Represses the Translation of STAT3 through 5' UTR	1
Implications of EBV-Encoded and EBV-Related miRNAs in Tumors	1
Meet the Editorial Board Member	1
Duchenne Muscular Dystrophy Gene Therapy	1
Cancer Treatment Evolution from Traditional Methods to Stem Cells and Gene Therapy	1
Expression of miR-92a in Green Tea EGCG Preconditioned Adiposederived Stem Cells Ameliorates Inflammatory Response and Increases Cartilage Regeneration in RA Rats through KLF4/IL-17/MMP-2 Axis Modulat	1
Advancing Antibacterial Strategies: CRISPR-Phage-Mediated Gene Therapy Targeting Bacterial Resistance Genes	1
Transforming RNA-Based Gene Therapy with Innovative Nanocarriersfor siRNA and miRNA Delivery	1
5-Alpha Reductase Deficiency - An Uncommon Disorder of Sexual Development: A Case Study of Four Turkish Patients within a Family	1
Acknowledgements to Reviewers	1
Preface-2026	1
ZNF695, A Potential Prognostic Biomarker, Correlates with Im mune Infiltrates in Cervical Squamous Cell Carcinoma and Endoce rvical Adenocarcinoma: Bioinformatic Analysis and Experimental Verification	1