OOIR: Observatory of International Research

Papers

(The median citation count of Current Gene Therapy is 1. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-04-01 to 2025-04-01.)

Article	Citations
Effective Combination of Single-cell Analysis and Gene Therapy	61
Synergizing CRISPR-Cas9 with Advanced Artificial Intelligence and Machine Learning for Precision Drug Delivery: Technological Nexus and Regulatory Insights	35
The Antimicrobial Peptide Pipeline: A Bacteria-Centric AMP Predictor	25
Immune Modulation Strategies in Gene Therapy: Overcoming Immune Barriers and Enhancing Efficacy	22
The Role of RNA m6A Modification in Cancer Glycolytic Reprogramming	22
Gene Therapy & Cell Therapy	21
Duchenne Muscular Dystrophy Gene Therapy	20
Hutchinson-Gilford Progeria Syndrome: An Overview of the Molecular Mechanism, Pathophysiology and Therapeutic Approach	18
ZNF695, A Potential Prognostic Biomarker, Correlates with Im mune Infiltrates in Cervical Squamous Cell Carcinoma and Endoce rvical Adenocarcinoma: Bioinformatic Analysis and Experimental Verification	17
Effect of Bovine Lactoferrin Treatment on Iron Homeostasis and Gene Expression Changes in Multiple Organ Dysfunctions During Wound Healing Process in Rats	15
Riding the Wave of Progress: Examining the Current Landscape and Future Potential of MicroRNAs in Cancer Gene Therapy	15
Meet the Editorial Board Member	14
Meet the Editorial Board Member	14
Development of Oral Bio-banks Past, Present and Future; Challenges and Opportunities	14
Gene Augmentation Techniques to Stimulate Wound Healing Process: Progress and Prospects	14
Viral Vector Delivery of DREADDs for CNS Therapy	13
Gene Therapy Cargoes Based on Viral Vector Delivery	12
Reversal of Neuropsychiatric Comorbidities in an Animal Model of Temporal Lobe Epilepsy Following Systemic Administration of Dental Pulp Stem Cells and Bone Marrow Mesenchymal Stem Cells	12
Gene Therapy for Critical Limb Ischemia: Per Aspera ad Astra	12
Therapeutic Effects of Mesenchymal Stem Cells Expressing Erythropoietin on Cancer-Related Anemia in Mice Model	11
Suppression of mTOR Expression by siRNA Leads to Cell Cycle Arrest and Apoptosis Induction in MDA-MB-231 Breast Cancer Cells	11
Exosomal miRNAs as Next-generation Therapy Vehicles in Breast Cancer	11
A Hypoxia-Regulated Retinal Pigment Epithelium-Specific Gene Therapy Vector Reduces Choroidal Neovascularization in a Mouse Model	11
Inferring Cell-type-specific Genes of Lung Cancer Based on Deep Learning	10
AAV9-coGLB1 Improves Lysosomal Storage and Rescues Central Nervous System Inflammation in a Mutant Mouse Model of GM1 Gangliosidosis	10

Mesenchymal Stromal Cells (MSCs): A Promising Tool for Cell-Based Angiogenic Therapy	10
CRISPR/Cas System: A Powerful Strategy to Improve Monogenic Human Diseases as Therapeutic Delivery; Current Applications and Challenges	9
The Role of Immunotherapy in Lung Cancer Treatment: Current Strategies, Future Directions, and Insights into Metastasis and Immune Microenvironment	9
FIGNL1 Promotes Hepatocellular Carcinoma Formation via Remodeling ECM-receptor Interaction Pathway Mediated by HMMR	8
Recent Progress of Machine Learning in Gene Therapy	8
Gene Therapy of Mucopolysaccharidosis Type I Mice: Repeated Administrations and Safety Assessment of pIDUA/Nanoemulsion Complexes	8
Human Retinal Pigment Epithelial Cells Overexpressing the Neuroprotective Proteins PEDF and GM-CSF to Treat Degeneration of the Neural Retina	8
Direct Bilirubin, but not Indirect Bilirubin, is Associated with Short-term Adverse Events in HFpEF	8
A Retrospective Analysis of the Lauren Classification in the Choice of XELOX or SOX as an Adjuvant Chemotherapy for Gastric Cancer	8
Gene Therapy in the Anterior Eye Segment	7
Reduced Immunogenicity of Intraparenchymal Delivery of Adeno-Associated Virus Serotype 2 Vectors: Brief Overview	7
Lipid-Based Nanocarriers for Targeted Gene Delivery in Lung Cancer Therapy: Exploring a Novel Therapeutic Paradigm	6
Mechanism of CAV and CAVIN Family Genes in Acute Lung Injury based on DeepGENE	6
DNA Vaccines to Improve Immunogenicity and Effectiveness in Cancer Vaccinations: Advancement and Developments	6
Theranostic Potential of Bacteriophages against Oral Squamous Cell Carcinoma	6
Effective Downregulation of BCR-ABL Tumorigenicity by RNA Targeted CRISPR-Cas13a	6
Effectiveness and Application Prospect of Microbiota-based Treatment	6
Gene Therapy for Chronic Traumatic Brain Injury: Challenges in Resolving Long-term Consequences of Brain Damage	6
Acknowledgements to Reviewers	6
Recent Advances in Predicting Protein-lncRNA Interactions Using Machine Learning Methods	6
Gene Therapy for Skin Aging	5
Teratogenic Toxicity Evaluation of Bladder Cancer-Specific Oncolytic Adenovirus on Mice	5
Applications of L-Arginine in Pregnancy and Beyond: An Emerging Pharmacogenomic Approach	5
Hemophilia Healing with AAV: Navigating the Frontier of Gene Therapy	5
Plasmalogens Activate AKT/mTOR Signaling to Attenuate Reactive Oxygen Species Production in Spinal Cord Injury	4
Splicing DNA Damage Adaptations for the Management of Cancer Cells	4
Identification and Analysis of RNA Editing Events in Ovarian Serous Cystadenoma Using RNA-seq Data	4
SFXN3 is Associated with Poor Clinical Outcomes and Sensitivity to the Hypomethylating Therapy in Non-M3 Acute Myeloid Leukemia Patients	4
Treatment of GM2 Gangliosidosis in Adult Sandhoff Mice Using an Intravenous Self-Complementary Hexosaminidase Vector	4
The Functions and Application Prospects of Hepatocyte Growth Factor in Reproduction	4
Gene Therapy Strategies for Glaucomatous Neurodegeneration	4
Proteomic Analyses Reveal Functional Pathways and Potential Targets in Pediatric Hydrocephalus	4
Amyotrophic Lateral Sclerosis Risk Genes and Suppressor	4
Cancer Treatment Evolution from Traditional Methods to Stem Cells and Gene Therapy	4
Acknowledgements to Reviewers	4
Exosomal MiR-29a in Cardiomyocytes Induced by Angiotensin II Regulates Cardiac Microvascular Endothelial Cell Proliferation, Migration and Angiogenesis by Targeting VEGFA	4
Clinical Development of Cell Therapies to Halt Lysosomal Storage Diseases: Results and Lessons Learned	4
Current Landscape of Gene Therapy for the Treatment of Cardiovascular Disorders	4
CRISPR-Cas9: Transforming Functional Genomics, Precision Medicine, and Drug Development – Opportunities, Challenges, and Future Directions	3
Segmentation of Thoracic Organs through Distributed Extraction of Visual Feature Patterns Utilizing Resio-Inception U-Net and Deep Cluster Recognition Techniques	3
Parkinson's Disease: From Bench to Bedside-Advancements in Diagnosis and Therapeutics using Pharmacogenomic Approach	3
A Quest to the Therapeutic Arsenal: Novel Strategies to Combat Multidrug- resistant Bacteria	3
Characteristics of BAY 2599023 in the Current Treatment Landscape of Hemophilia A Gene Therapy	3
Current Landscape and Emerging Opportunities of Gene Therapy with Non-viral Episomal Vectors	3
Exploring Genetic and Receptor-Based Dopaminergic Strategies for Antidepressant Drug Development	3
Target and Gene-Based Therapeutic Strategies against Pancreatic Cancer: Current and Future Prospects	3
Delivery of Superoxide Dismutase 3 Gene with Baculoviruses Inhibits TNF-α Triggers Vascular Smooth Muscle Cell Proliferation and Inflammation	3
Gene Therapy for Rare Genetic Diseases	3
Therapeutic Potential of CRISPR/Cas in Hashimoto's Thyroiditis: A Comprehensive Review	3
Optogenetics: Illuminating the Future of Hearing Restoration and Understanding Auditory Perception	3

Recent Advances in CRISPR/Cas9 Directed Base Editing	3
DeepLCRmiRNA: A Hybrid Neural Network Approach for Identifying Lung Cancer-Associated miRNAs	3
Mammalian Stable Cell Platforms for Recombinant Adeno-associated Virus (rAAV) Production: Development Strategies and their Impact on Viral Productivity	2
Single-cell and Bulk Transcriptomic Analyses Reveal a Stemness and Circadian Rhythm Disturbance-related Signature Predicting Clinical Outcome and Immunotherapy Response in Hepatocellular Carcinoma	2
CAR-NK Cells for Cancer Therapy: Molecular Redesign of the Innate Antineoplastic Response	2
In Situ Gene Therapy	2
Therapeutic Potential of POU3F3, a Novel Long Non-coding RNA, Alleviates the Pathogenesis of Osteoarthritis by Regulating the miR-29a- 3p/FOXO3 Axis	2
Biogenesis and Function of circRNAs in Pulmonary Fibrosis	2
Dysregulation of Transfer RNA-derived Small RNAs that Regulate Cell Activity and its Related Signaling Pathways in Human Cancers	2
SHR6390 Combined with Cabozantinib Inhibits Tumor Progression in the Hepatocellular Carcinoma Mouse Model	2
Identification of HnRNP Family as Prognostic Biomarkers in Five Major Types of Gastrointestinal Cancer	2
Isoliquiritin Ameliorates Ulcerative Colitis in Rats through Caspase 3/HMGB1/TLR4 Dependent Signaling Pathway	2
Prediction of SARS-CoV-2 Infection Phosphorylation Sites and Associations of these Modifications with Lung Cancer Development	2
Role of Non-coding RNAs on the Radiotherapy Sensitivity and Resistance in Cancer Cells	1
Gene Therapy, A Potential Therapeutic Tool for Neurological and Neuropsychiatric Disorders: Applications, Challenges and Future Perspective	1
Identification of the Metabolic Characteristic of Organ Fibrosis Using Microbial Analysis on RNA-seq Data	1
Pan-Cancer Single-Cell Analysis Revealing the Heterogeneity of Cancer-Associated Fibroblasts in Skin Tumors	1
Efficacy of Gene Therapy to Restore Cognition in Alzheimer’s Disease: A Systematic Review	1
The Effectiveness of Nanoparticles on Gene Therapy for Glioblastoma Cells Apoptosis: A Systematic Review	1
High-Throughput Sequencing Reveals N6-Methyladenosine-modified LncRNAs as Potential Biomarkers in Mice with Liver Fibrosis	1
HCST Expression Distinguishes Immune-hot and Immune-cold Subtypes in Pancreatic Ductal Adenocarcinoma	1
Identification of Chronic Hypersensitivity Pneumonitis Biomarkers with Machine Learning and Differential Co-expression Analysis	1
Unraveling Glioblastoma: TME Implication and Gene Therapy Advances	1
CRISPR/Cas9-based Gene Therapies for Fighting Drug Resistance Mediated by Cancer Stem Cells	1
Proteogenomic Identification and Analysis of KIF5B as a Prognostic Signature for Hepatocellular Carcinoma	1
Targeting Undruggable Proteins: The siRNA Revolution Beyond Small Molecules - Advances, Challenges, and Future Prospects in Therapeutic Innovation	1
Computational Analysis Illustrates the Mechanism of Qingfei Paidu Decoction in Blocking the Transition of COVID-19 Patients from Mild to Severe Stage	1
Comprehensive Analysis and Experimental Validation of HEPACAM2 as a Potential Prognosis Biomarker and Immunotherapy Target in Colorectal Cancer	1
Neurotrophins as Potential Gene Therapy Targets for Huntington's Disease	1
CRISPR/Cas9 Technology as a Modern Genetic Manipulation Tool for Recapitulating of Neurodegenerative Disorders in Large Animal Models	1
Exosome miR-30a-5p Regulates Glomerular Endothelial Cells' EndMT and Angiogenesis by Modulating Notch1/VEGF Signaling Pathway	1
Non-coding RNAs in Regulation of Protein Aggregation and Clearance Pathways: Current Perspectives Towards Alzheimer's Research and Therapy	1
MDAlmc: A Novel Low-rank Matrix Completion Model for MiRNADisease Association Prediction by Integrating Similarities among MiRNAs and Diseases	1