OOIR: Observatory of International Research

Papers

(The TQCC of Current Gene Therapy is 7. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2020-05-01 to 2024-05-01.)

Article	Citations
miRNA-146a Improves Immunomodulatory Effects of MSC-derived Exosomes in Rheumatoid Arthritis	67
The Emerging Role of Stem Cells in Regenerative Dentistry	42
Gene Therapy in the Anterior Eye Segment	40
Integrated Analysis of mRNA-seq and miRNA-seq to Identify c-MYC, YAP1 and miR-3960 as Major Players in the Anticancer Effects of Caffeic Acid Phenethyl Ester in Human Small Cell Lung Cancer Cell Line	34
Applications of Recombinant Adenovirus-p53 Gene Therapy for Cancers in the Clinic in China	32
Exosomes: Structure, Biogenesis, Types and Application in Diagnosis and Gene and Drug Delivery	25
CD24, A Review of its Role in Tumor Diagnosis, Progression and Therapy	22
Strategic Developments & Future Perspective on Gene Therapy for Breast Cancer: Role of mTOR and Brk/ PTK6 as Molecular Targets	22
Gene Therapy, A Novel Therapeutic Tool for Neurological Disorders: Current Progress, Challenges and Future Prospective	22
Recent Progress of Machine Learning in Gene Therapy	18
Inferring Cell-type-specific Genes of Lung Cancer Based on Deep Learning	18
Gene Therapy Approaches in an Autoimmune Demyelinating Disease: Multiple Sclerosis	18
Single-cell RNA Sequencing Analysis Identifies Key Genes in Brain Metastasis from Lung Adenocarcinoma	15
Recent Advances in Predicting Protein-lncRNA Interactions Using Machine Learning Methods	15
Molecular Genetics of Early- and Late-Onset Alzheimer’s Disease	14
Computational Analysis Illustrates the Mechanism of Qingfei Paidu Decoction in Blocking the Transition of COVID-19 Patients from Mild to Severe Stage	13
Hutchinson-Gilford Progeria Syndrome: An Overview of the Molecular Mechanism, Pathophysiology and Therapeutic Approach	13
Combined Analysis of Clinical Data on HGF Gene Therapy to Treat Critical Limb Ischemia in Japan	13
miR-1-3p/CELSR3 Participates in Regulating Malignant Phenotypes of Lung Adenocarcinoma Cells	12
Stem Cell Transplantation Improves Ovarian Function through Paracrine Mechanisms	11
Gene Therapy Based on Lipid Nanoparticles as Non-viral Vectors for Glioma Treatment	11
Promising Gene Therapy Using an Adenovirus Vector Carrying REIC/Dkk-3 Gene for the Treatment of Biliary Cancer	11
Mesenchymal Stem Cells Promote Caspase Expression in Molt-4 Leukemia Cells Via GSK-3α/Β and ERK1/2 Signaling Pathways as a Therapeutic Strategy	11
Artificial RNA Editing with ADAR for Gene Therapy	11
A Five-gene Signature for Predicting the Prognosis of Colorectal Cancer	11

Cancer Treatment Evolution from Traditional Methods to Stem Cells and Gene Therapy	11
Systemic Therapy for Hepatocellular Carcinoma: Advances and Hopes	10
Identification of Chronic Hypersensitivity Pneumonitis Biomarkers with Machine Learning and Differential Co-expression Analysis	10
Effect of Rat Bone Marrow Derived-Mesenchymal Stem Cells on Granulocyte Differentiation of Mononuclear Cells as Preclinical Agent in Cellbased Therapy	10
Predicting LncRNA-Disease Association Based on Generative Adversarial Network	10
Feasibility of Mesenchymal Stem Cell Therapy for COVID-19: A Mini Review	10
miR-375 Inhibits the Proliferation, Migration and Invasion of Esophageal Squamous Cell Carcinoma by Targeting XPR1	10
CAR-NK Cells for Cancer Therapy: Molecular Redesign of the Innate Antineoplastic Response	10
Current Landscape and Emerging Opportunities of Gene Therapy with Non-viral Episomal Vectors	10
MicroRNAs: A Critical Regulator and a Promising Therapeutic and Diagnostic Molecule for Diabetic Cardiomyopathy	9
Omics Data and Artificial Intelligence: New Challenges for Gene Therapy	9
Mesenchymal Stromal Cells (MSCs): A Promising Tool for Cell-Based Angiogenic Therapy	9
Potential Prognostic Predictors and Molecular Targets for Skin Melanoma Screened by Weighted Gene Co-expression Network Analysis	9
Therapeutic Potential of POU3F3, a Novel Long Non-coding RNA, Alleviates the Pathogenesis of Osteoarthritis by Regulating the miR-29a- 3p/FOXO3 Axis	9
Gene Therapy in the Management of Parkinson’s Disease: Potential of GDNF as a Promising Therapeutic Strategy	9
Exploring the Role of Gene Therapy for Neurological Disorders	9
CRISPR Systems Suitable for Single AAV Vector Delivery	8
CRISPR/Cas9 Technology as a Modern Genetic Manipulation Tool for Recapitulating of Neurodegenerative Disorders in Large Animal Models	8
NF1, Neurofibromin and Gene Therapy: Prospects of Next-Generation Therapy	8
The Effectiveness of Nanoparticles on Gene Therapy for Glioblastoma Cells Apoptosis: A Systematic Review	8
Potential Non-coding RNAs from Microorganisms and their Therapeutic Use in the Treatment of Different Human Cancers	8
Gene Therapy, A Potential Therapeutic Tool for Neurological and Neuropsychiatric Disorders: Applications, Challenges and Future Perspective	8
Popularizing Recombinant Baculovirus-derived OneBac System for Laboratory Production of all Recombinant Adeno-associated Virus Vector Serotypes	7
Gene Therapy for Hemophilia A: Where We Stand	7
Genetically-modified Stem Cell in Regenerative Medicine and Cancer Therapy; A New Era	7
Current Designs of Polymeric Platforms Towards the Delivery of Nucleic Acids Inside the Cells with Focus on Polyethylenimine	7
Therapeutic Approaches for the Management of Autoimmune Disorders via Gene Therapy: Prospects, Challenges and Opportunities	7
γ-Aminobutyric Acid Promotes Osteogenic Differentiation of Mesenchymal Stem Cells by Inducing TNFAIP3	7
Delivery Systems for RNA Interference Therapy: Current Technologies and Limitations	7
Prader-Willi Syndrome: Molecular Mechanism and Epigenetic Therapy	7
Promising Anti-stroke Signature of Voglibose: Investigation through In- Silico Molecular Docking and Virtual Screening in In-Vivo Animal Studies	7