OOIR: Observatory of International Research

Papers

(The TQCC of Current Gene Therapy is 7. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2022-05-01 to 2026-05-01.)

Article	Citations
Effective Combination of Single-cell Analysis and Gene Therapy	47
A Comprehensive Review of Genetic Risk Factors for Alzheimer’s Disease Development	32
A Retrospective Analysis of the Lauren Classification in the Choice of XELOX or SOX as an Adjuvant Chemotherapy for Gastric Cancer	32
Gene Augmentation Techniques to Stimulate Wound Healing Process: Progress and Prospects	32
Identifying Key Epigenetic Modification-Related Genes for Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma and Cellular Validation	28
Synergizing CRISPR-Cas9 with Advanced Artificial Intelligence and Machine Learning for Precision Drug Delivery: Technological Nexus and Regulatory Insights	26
Evaluation of the Cellular Effects of miR-30d-3p in A549 Cells Under Normoxic and Hypoxic Conditions	25
Next-Generation Whole-Exome Pattern: Advanced Methods and Clinical Significance	24
Identifying ARRB2 as a Prognostic Biomarker and Key Player in the Tumor Microenvironment of Pancreatic Cancer through scPagwas Methodology	23
DNA Vaccines to Improve Immunogenicity and Effectiveness in Cancer Vaccinations: Advancement and Developments	22
Acknowledgements to Reviewers	22
Applications of L-Arginine in Pregnancy and Beyond: An Emerging Pharmacogenomic Approach	21
Therapeutic Potential of POU3F3, a Novel Long Non-coding RNA, Alleviates the Pathogenesis of Osteoarthritis by Regulating the miR-29a- 3p/FOXO3 Axis	21
MDAlmc: A Novel Low-rank Matrix Completion Model for MiRNADisease Association Prediction by Integrating Similarities among MiRNAs and Diseases	21
Identification and Validation of Amino Acid Metabolism-Related Biomarkers and Investigation of their Potential Mechanisms in Lung Adenocarcinoma	20
Comprehensive Analysis and Experimental Validation of HEPACAM2 as a Potential Prognosis Biomarker and Immunotherapy Target in Colorectal Cancer	20
Human Virus-Like Proteins: Implications for Gene Therapy	19
The Role of Myeloid-derived Suppressor Cells and Non-tumor Cells in theGlioma Microenvironment	18
Discovery of Genes Related to Cuproptosis and Mitophagy to Improve Myocardial Infarction Diagnosis and Treatment	17
Harnessing Nanotechnology and Gene Editing for Cancer Therapy: ASynergistic Approach to Precision Medicine	15
TRPM8 as a Potential Biomarker and Therapeutic Target for Gastric Cancer Identified by a Combination of Text Mining and RNA Sequencing	15
Anesthesia and Cancer: Something More than Avoiding Stress Response	14
Advancements in CAR-T Cell Therapy for Ovarian Cancer: Current Strategies and Future Directions	14
A Complete Sojourn of Gene Therapy along with its Targeting Approaches for the Treatment of the Major Depressive Disorder	14
From DNA Editing to RNA Regulation: The Breakthroughs of CRISPR and Mega-CRISPR	14

Significance of Ribonucleoside-diphosphate Reductase Subunit M2 in Lung Adenocarcinoma	14
Corrigendum to: Neuroprotection by Human Dental Pulp Mesenchymal Stem Cells: From Billions to Nano	12
Lentiviral Micro-dystrophin Gene Treatment into Late-stage mdx Mice for Duchenne Muscular Dystrophy Disease	12
Role of Long Non-Coding RNA in Regulating ER Stress Response to the Progression of Diabetic Complications	12
Probing the Depths of Molecular Complexity: STAT3 as a Key Architect in Colorectal Cancer Pathogenesis	12
A Hypoxia-Regulated Retinal Pigment Epithelium-Specific Gene Therapy Vector Reduces Choroidal Neovascularization in a Mouse Model	11
Revolutionizing Drug and Gene Delivery: Cutting-Edge Smart Polymers for Precision Release	11
Therapeutic Effects of Mesenchymal Stem Cells Expressing Erythropoietin on Cancer-Related Anemia in Mice Model	11
Selecting Candidates for Genetic Therapy: A Patient-Centered Framework	11
Therapeutic Effects of Mesenchymal Stem Cells Carrying Echovirus inMouse Models of Breast Cancer	11
Effect of Bovine Lactoferrin Treatment on Iron Homeostasis and Gene Expression Changes in Multiple Organ Dysfunctions During Wound Healing Process in Rats	11
The Mitochondrial Deoxyribonucleic Acid Puzzle: Controversies, Challenges, and Critical Perspectives A Narrative Review	10
Splicing DNA Damage Adaptations for the Management of Cancer Cells	10
CRISPR-Cas9: A Paradigm Shift in Gene Editing Addressing Antimicrobial Resistance	10
Mechanism of CAV and CAVIN Family Genes in Acute Lung Injury based on DeepGENE	10
Gene Therapy for Chronic Traumatic Brain Injury: Challenges in Resolving Long-term Consequences of Brain Damage	10
Gene Therapy for Rare Genetic Diseases	9
Padlock Assay in Transthyretin Amyloidosis: A Feasibility Study	9
Reduced Immunogenicity of Intraparenchymal Delivery of Adeno-Associated Virus Serotype 2 Vectors: Brief Overview	9
Hemophilia Healing with AAV: Navigating the Frontier of Gene Therapy	9
Revolution of Traditional Chinese Medicine in Anticancer Therapy, Applications and Future Perspective	9
Non-coding RNAs in Regulation of Protein Aggregation and Clearance Pathways: Current Perspectives Towards Alzheimer's Research and Therapy	9
Synergistic Antiproliferative Effects of EGCG and Myricetin on Cervical Cancer Biomarkers in ME180 and SiHa Cell Lines	9
Role of Exosomal miRNAs and Epigenetic Modifications in Diabetic Nephropathy: Insights into Novel Diagnostic and Therapeutic Strategies	8
Segmentation of Thoracic Organs through Distributed Extraction of Visual Feature Patterns Utilizing Resio-Inception U-Net and Deep Cluster Recognition Techniques	8
HCST Expression Distinguishes Immune-hot and Immune-cold Subtypes in Pancreatic Ductal Adenocarcinoma	8
Biogenesis and Function of circRNAs in Pulmonary Fibrosis	8
Transcription Factor EB Drives Thrombospondin-1 Expression to Dampen Focal-adhesion Signaling and Limit Post-infarction Cardiac Fibrosis	7
A Paradigm Shift in Hemophilia Care: The Promise of Gene Therapy	7
A Comprehensive Review on Human Metapneumovirus	7
Unraveling Etiological Indications and Therapeutic Implications of Familial Cerebral Cavernous Malformations in the Dawn of Gene Therapy for Monogenic Conditions	7
Pan-Cancer Single-Cell Analysis Revealing the Heterogeneity of Cancer- Associated Fibroblasts in Skin Tumors	7
Prediction of SARS-CoV-2 Infection Phosphorylation Sites and Associations of these Modifications with Lung Cancer Development	7
Computational Analysis Illustrates the Mechanism of Qingfei Paidu Decoction in Blocking the Transition of COVID-19 Patients from Mild to Severe Stage	7
Novel Perspective of Regulating P53/Bcl2/Caspase-3 via In vitro Targeted AFP Gene Knocks Out in HepG2 Cells Using CRISPR/Cas9 Editing Tool	7
Dissecting the Mechanisms of Intestinal Immune Homeostasis by Analyzing T-Cell Immune Response in Crohn's Disease and Colorectal Cancer	7
Immunoinformatic Based Designing of Immune Boosting and Nonallergenic Multi-epitope Subunit Vaccine Against the Enterovirus D68	7
Folic Acid-Conjugated Nanocarriers for Targeted Cancer Therapy: Recent Patents and Future Prospects	7
Single-cell and Bulk Transcriptomic Analyses Reveal a Stemness and Circadian Rhythm Disturbance-related Signature Predicting Clinical Outcome and Immunotherapy Response in Hepatocellular Carcinoma	7
Untangling the Genetic Threads of Alzheimer's: Insights into Risk Factors and Biomarkers	7