OOIR: Observatory of International Research

Papers

(The TQCC of Current Molecular Medicine is 4. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-04-01 to 2025-04-01.)

Article	Citations
In Transfusion-Dependent Thalassemia Children, Increased Iron Overload is Associated with Lower Serum Alpha-Klotho, Which is Strongly Associated with Lower Total and Ionized Calcium Concentrations	95
Genetic Aspects of Glaucoma: An Updated Review	32
Insight to Combat Post COVID-19 Mortality: Complications and their Biomarkers	30
Diabetic Neuropathy: Review on Molecular Mechanisms	29
LncRNAs Roles in Chemoresistance of Cancer Cells	26
The Roles of Mitochondrial Dysfunction and Reactive Oxygen Species in Aging and Senescence	24
Transcription Factors in Deriving β Cell Regeneration: A Potential Novel Therapeutic Target	21
Reversal of Mucin 1 Reduction-Induced Enterocyte Apoptosis by Retinoic Acid through the PI3K/AKT Signaling Pathway in an In vitro Model of Necrotizing Enterocolitis	19
Role of Immune Cells in Mediating the Causal Effect of Gut Microbiota on Type 2 Diabetes	19
Interferon Epsilon: Properties and Functions	19
ORLNC1 Suppresses Cell Growth in HER2-Positive Breast Cancer via miRNA-296 Sponging	16
An Insight into the Role of E2F1 in Breast Cancer Progression, Drug Resistance, and Metastasis	16
Ubiquitin Mediated Degradation of EGFR by 17 β-estradiol in Triple Negative MDA-MB-231 (TNBC) Breast Cancer Cells Line	15
Therapeutic Role of Desmodium Species on its Isolated Flavonoids	15
Artemisia Species as a New Candidate for Diabetes Therapy: A Comprehensive Review	14
Altered Expression of microRNAs in Serum Extracellular Vesicles in Rats with Severe Burns during Shock Stage	14
Bioactive Loaded Lipid-based Nanostructures: A Novel Insight for Age-related Neurodegeneration	13
Toosendanin Restrains Idiopathic Pulmonary Fibrosis by Inhibiting ZEB1/CTBP1 Interaction	12
The Relation of the Viral Structure of SARS-CoV-2, High-Risk Condition, and Plasma Levels of IL-4, IL-10, and IL-15 in COVID-19 Patients Compared to SARS and MERS Infections	12
Molecular and Epigenetic Basis of Extracellular Vesicles Cell Repair Phenotypes in Targeted Organ-specific Regeneration	12
The Role of Skin and Gut Microbiome and Epigenetic Modifications in Skin-Autoimmune Disorders	12
Resveratrol-Exemestane Beneficial Regimen to Overcome the Complications over Existing Therapies for the Management of Breast Cancer	12
Preface	12
An Inventory of Diagnostic Tools for Detection of COVID-19	11
Adipose Tissue-Mesenchymal Stem Cells Caused to Change the Methylation Status of hTERT Gene Promoter CpG Islands of Molt-4 Leukemia Cells as Cell-based Therapy	11

JAK2-mediated Intracellular Signaling	11
Cytokine Analysis in Patients with Different Stages of Thromboangiitis Obliterans	11
An Overview of Invasive Ductal Carcinoma (IDC) in Women’s Breast Cancer	11
HGF, HNRPD, and sFLT1 Interfere with the Induction of VEGF in Patients with Severe Psoriasis	11
Macrophages and Pulmonary Fibrosis	11
Deeper Insight in Metastatic Cancer Progression; Epithelial-to- Mesenchymal Transition and Genomic Instability: Implications on Treatment Resistance	10
Pharmacodynamic Stance of Phytoconstituents as a Gastric Ulcer Protective Mechanism: An Overview	10
Brain MRI in Monogenic Cerebral Small Vessel Diseases: A Practical Handbook	10
Ocimum sanctum [Tulsi] as a Potential Immunomodulator for the Treatment of Ischemic Injury in the Brain	10
The Diverse Roles of Long Non-Coding RNA HOTTIP in Breast and Gynecological Cancer Progression	10
Recent Accomplishments in Exhaled Breath Condensate Analysis - Molecular Aspects	10
Histone Deacetylase 2 Stabilizes SPARC-related Modular Calcium Binding 2 to Promote Metastasis and Stemness in Gallbladder Cancer	9
Efferocytosis and Metabolic Syndrome: A Narrative Review	9
Epigenetic Reprogramming and Landscape of Transcriptomic Interactions: Impending Therapeutic Interference of Triple-Negative Breast Cancer in Molecular Medicine	9
Lavender Plant: Farming and Health Benefits	9
The Association between Cadmium Exposure and Thyroid Function in Animals: A Systematic Review	9
Investigation of the Anti-Cancer Effects of Free and PLGA-PAA Encapsulated Hydroxytyrosol on the MCF-7 Breast Cancer Cell Line	9
WITHDRAWN: Piezo1 Mediates Inflammation in Balloon-inflated Rat Brain and its Bidirectional Mechanosensitivity	9
Attenuation of NLRP3 Inflammasome by Cigarette Smoke is Correlated with Decreased Defense Response of Oral Epithelial Cells to Candida albicans	9
Aberrant β-catenin Activity in Hepatoid Adenocarcinoma of the Stomach	9
Intracellular Ellagic Acid Derived from Goat Urine DMSO Fraction (GUDF) Predicted as an Inhibitor of c-Raf Kinase	9
Associations between Gut Microbiota and Microbial Metabolites in Adjuvant- induced Arthritis Rats with Moist Heat Arthralgia Spasm Syndrome	8
The Key Roles of Makorin RING Finger Protein 3 (MKRN3) During the Development of Pubertal Initiation and Central Precocious Puberty (CPP)	8
Expression of Transcriptional Factors of T Helper Differentiation (T-bet, GATA-3, RORγt, and FOXP3), MIF Receptors (CD44, CD74, CXCR2, 4, 7), and Th1, Th2, and Th17 Cytokines in PBMC from Control Subj	8
Potentiation of Tumor Hallmarks by the Loss of GULO, a Vitamin C Biosynthesis Gene in Humans	8
Pre-clinical Efficacy and Safety Pharmacology of PEGylated Recombinant Human Endostatin	8
NEDD4 Knockdown Suppresses Human Endometrial Stromal Cell Growth and Invasion by Regulating PTGS2-Mediated Ferroptosis in Endometriosis	8
A New Strategy for Obesity Treatment: Revealing the Frontiers of Anti-obesity Medications	8
Stem Cell-Based or Cell-Free Gene Therapy in Chondrocyte Regeneration: Synovial Fluid-Derived Mesenchymal Stem Cell Exosomes	8
Circulating miRNA in Atherosclerosis: A Clinical Biomarker and Early Diagnostic Tool	7
Transcriptome Profiling of Cisplatin Resistance in Triple-negative Breast Cancer: New Insight into the Role of PI3k/Akt Pathway	7
Experimental and Computational Study of Hyaluronidase Interactions with Glycosaminoglycans and their Ligands	7
The Molecular Mechanism of a Complex1-Induced Apoptosis in Cancer Cells of the Esophagus	7
Autophagy-related Prognostic Signature in HER2 Positive Gastric Carcinomas	7
NF-κB1 Intronic Region Polymorphisms as Risk Factor for Head and Neck Cancer in HPV-Infected Population from Pakistan	7
Neferine Targeted the NLRC5/NLRP3 Pathway to Inhibit M1-type Polarization and Pyroptosis of Macrophages to Improve Hyperuricemic Nephropathy	7
Does the Interaction of KIR and HLA Affect the Development of Non-Infectious Uveitis?	7
The Role of Platelet in Severe and Fatal Forms of COVID-19	7
Crocetin Suppresses Uterine Ischemia/Reperfusion-induced Inflammation and Apoptosis through the Nrf-2/HO-1 Pathway	7
USP3 inhibition is Active Against Chemo-resistant Hepatocellular Carcinoma Anchorage-independent Growth via Suppressing Wnt/β-catenin	7
Emerging Treatment Approaches for COVID-19 Infection: A Critical Review	7
The Emerging Role of LncRNA AWPPH in Multiple Cancers: A Review Study	6
Breviscapine Combined with BMSCs Reduces Aβ Deposition in Rat with Alzheimer's Disease by Regulating Circular RNA ciRS-7	6
Darolutamide as a Second-Generation Androgen Receptor Inhibitor in the Treatment of Prostate Cancer	6
Correlation Between Dexamethasone and miRNAs in the Regulation of Apoptosis, Drug-resistance, and Metastasis of Cancer Cell	6
Altered Expression of TRIM Proteins - Inimical Outcome and Inimitable Oncogenic Function in Breast Cancer with Diverse Carcinogenic Hallmarks	6
Critical Role of NFκB in the Pathogenesis of Non-alcoholic Fatty Liver Disease: A Widespread Key Regulator	6
LncRNA-DANCR: A Key Player in Colorectal Cancer Development and Progression	6
Piwi-interacting RNAs (piRNAs) and Colorectal Carcinoma: Emerging Non-invasive diagnostic Biomarkers with Potential Therapeutic Target Based Clinical Implications	6
Free Radicals and Oxidative Stress: Signaling Mechanisms, Redox Basis for Human Diseases, and Cell Cycle Regulation	6

Chemotherapeutics for Acute Erythroid Leukemia: Research, Present and Future	6
Albiflorin Alleviates Sepsis-induced Acute Liver Injury through mTOR/p70S6K Pathway	6
Preclinical Evidence-based Review on Therapeutic Potential of Eugenol for the Treatment of Brain Disorders	6
MiR-148b Caused Liver Injury in Rats with Traumatic Hemorrhagic Shock by Inhibiting SIRT6 Expression	6
The Expression and Molecular Mechanisms of Matrix Metalloproteinase- 9 and Vascular Endothelial Growth Factor in Renal Interstitial Fibrosis in Rats	6
Targeting tumor hypoxia and hypoxia-inducible factors (HIFs) for the treatment of cancer- A story of transcription factors with novel approach in molecular medicine	6
The Importance of mir-491-5p in Various Cancers	6
Role of Innate Immune and Inflammatory Responses in the Development of Secondary Diabetic Complications	6
Tumor Mutational Burden as a Biomarker of Immunotherapy Response: An Immunogram Approach in Onco-immunology	6
Helicobacter pylori Biofilm and New Strategies to Combat it	6
Sema3A Alleviates the Malignant Behaviors of Gastric Cancer Cells by Inhibiting NRP-1	6
Role of Extracellular Vesicles in Alzheimer’s Disease: Current Advances	5
The Regulatory Role of Pivotal MicroRNAs in the AKT Signaling Pathway in Breast Cancer	5
Therapeutic Measures for the Novel Coronavirus: A Review of Current Status and Future Perspective	5
Autophagy as an Anti-senescent in Aging Neurocytes	5
High TLX1 Expression Correlates with Poor Prognosis and Immune Infiltrates in Patients with Lung Adenocarcinoma	5
Pharmacological Potential of Bioactive Peptides for the Treatment of Diseases Associated with Alzheimer's and Brain Disorders	5
MicroRNAs in the Pathogenesis of Ankylosing Spondylitis and their Clinical Implication	5
Diagnostic, Prognostic, and Therapeutic Value of miR-148b in Human Cancers	5
A Review of DNA and Histone Methylation Alterations in the New Era of Diagnosis and Treatment of Retinal Diseases	5
The Protective Effect of Curcumin Against Cardiotoxic Effects Induced by Chronic Exposure to Chlorpyrifos	5
Pharmacological Profile of Novel Anti-cancer Drugs Approved by USFDA in 2022: A Review	5
The Marine Factor 3,5-dihydroxy-4-methoxybenzyl Alcohol Suppresses Cell Growth, Inflammatory Cytokine Production, and NF-κB Signaling-enhanced Osteoclastogenesis in In vitro Mouse Macrophages RAW264.7	5
Molecular Pathways, Targeted Therapies, and Proteomic Investigations of Colorectal Cancer	5
The Role of Pro-fibrotic Myofibroblasts in Systemic Sclerosis: From Origin to Therapeutic Targeting	5
WITHDRAWN: LncRNA-PVT1 Inhibition Protects Neuron Injury During Cerebral Ischemia Injury through Targeting the miRNA-187-3p- MyD88 Signaling Pathway	5
The Impact of Cell-free Plasma DNA on Metastatic and Nonmetastatic Prostate Cancer	5
Exercise and Mitochondrial Function: Importance and Inference- A Mini Review	5
Exosomal microRNAs: A Diagnostic and Therapeutic Small Bio-molecule in Esophageal Cancer	5
Anlotinib Inhibiting Mantle Cell Lymphoma Proliferation and Inducing Apoptosis through PI3K/AKT/mTOR Pathway	5
CTLA-4: As an Immunosuppressive Immune Checkpoint in Breast Cancer	5
Preface	5
siRNA Mediated Downregulation of RhoA Expression Reduces Oxidative Induced Apoptosis in Retinal Ganglion Cells	4
SHMT2 is Associated with Tumor Purity, CD8+ T Immune Cells Infiltration, and a Novel Therapeutic Target in Four Different Human Cancers	4
The Role of Resveratrol in Aging and Senescence: A Focus on Molecular Mechanisms	4
Human Colon Cancer HT29 Cell Line Treatment with High-Dose LAscorbic Acid Results to Reduced Angiogenic Proteins Expression and Elevated Pro-apoptotic Proteins Expression	4
Acknowledgements to Reviewers	4
Aptamers for Brain Tumors: A Therapeutic Agent for Effectively Crossing the Blood-Brain Barrier	4
Therapeutic Effects of Berberine against Urological Cancers: Biological Potentials Based on Cellular Mechanisms	4
Non-coding RNAs in Precursor Lesions of Colorectal Cancer: Their Role in Cancer Initiation and Formation	4
The Role of Vitamins in DNA Methylation as Dietary Supplements or Neutraceuticals: A Systematic Review	4
Regenerative Potential of Mesenchymal Stem Cell-Derived Extracellular Vesicles	4
Diet-induced Obesity Differentially Modulates Cardiac Inflammatory Status in the C57 and FVB Mouse Strains	4
Establishment and Validation of Lactate Metabolism-Related Genes as a Prognostic Model for Gastric Cancer	4
Combinatorial Chemosensitive Nanomedicine Approach for the Treatment of Breast Cancer	4
Peptide and Small Molecule Inhibitors Targeting Myeloid Cell Leukemia 1 (Mcl-1) as Novel Antitumor Agents	4
Protein PDK4 Interacts with HMGCS2 to Facilitate High Glucoseinduced Myocardial Injuries	4
Apigenin Inhibits Proliferation, Migration, and Invasion of Human Tongue Carcinoma Tca8113 Cells Through Regulating the MAPK Signaling Pathways	4
Nuclear Imaging Modalities in the Diagnosis and Management of Thyroid Cancer	4
COL12A1 Promotes Osteosarcoma Progression via the FAK/PI3K/AKT/mTOR Pathway	4
CRISPR-Cas9: A Potent Gene-editing Tool for the Treatment of Cancer	4
The Therapeutic Effect of Stem Cells on Chemotherapy-Induced Premature Ovarian Failure	4
Chronic Administration of Methamphetamine Aggravates Atherosclerotic Vulnerable Plaques in Apolipoprotein E Knockout Mice Fed with a High-cholesterol Diet	4
A Mini-Review on Elisa-Based Diagnosis of Schistosomiasis	4
Cholinergic Transporters Serve as Potential Targets in Alzheimer’s Disease	4
miR-34 as a Critical Regulator in Ovarian Cancer	4
Molecular Methods for Diagnosis of Monkeypox: A Mini-review	4
The Antidiabetic Mechanisms of Hesperidin: Hesperidin Nanocarriers as Promising Therapeutic Options for Diabetes	4
Fascin Inhibitor NP-G2-044 Decreases Cell Metastasis and Increases Overall Survival of Mice-Bearing Lung Cancers	4
Emerging Role of Ferroptosis in Breast Cancer: Characteristics, Therapy, and Translational Implications for the Present and Future	4
Tanshinone Alleviates UVA-induced Melanogenesis in Melanocytes via the Nrf2-regulated Antioxidant Defense Signaling Pathway	4
Ferroptosis and Cancer Immunotherapy	4
Several Applications of Solid Lipid Nanoparticles in Drug Delivery	4
Human Recombinant Relaxin (Serelaxin) as Anti-fibrotic Agent: Pharmacology, Limitations and Actual Perspectives	4
Using the AP1 Transcription Factor FOSL1 to Assess the Exacerbation of Psoriasis	4