OOIR: Observatory of International Research

Papers

(The TQCC of Current Molecular Medicine is 4. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2020-05-01 to 2024-05-01.)

Article	Citations
Circular RNA and Diabetes: Epigenetic Regulator with Diagnostic Role	51
Free Radicals and Oxidative Stress: Signaling Mechanisms, Redox Basis for Human Diseases, and Cell Cycle Regulation	43
Alzheimer’s Disease: A Contextual Link with Nitric Oxide Synthase	24
Rapid Determination of Full and Empty Adeno-Associated Virus Capsid Ratio by Capillary Isoelectric Focusing	24
The Role of the PI3K/AKT/mTOR Signalling Pathway in Male Reproduction	23
An Overview of Available Antimalarials: Discovery, Mode of Action and Drug Resistance	22
The Roles of Mitochondrial Dysfunction and Reactive Oxygen Species in Aging and Senescence	19
Circulating miRNA in Atherosclerosis: A Clinical Biomarker and Early Diagnostic Tool	19
Hepatocyte Growth Factor Secreted from Human Adipose-Derived Stem Cells Inhibits Fibrosis in Hypertrophic Scar Fibroblasts	18
The Antihypertensive, Antimicrobial and Anticancer Peptides from Arthrospira with Therapeutic Potential: A Mini Review	18
The Role of Retinoblastoma Protein in Cell Cycle Regulation: An Updated Review	17
Studying Adsorption and Cellular Toxicity of Boron Nitride Nanostructure versus Melphalan Anti-ovarian Cancer Drug	17
The Functional Role of Long Non-coding RNA UCA1 in Human Multiple Cancers: a Review Study	17
JAK2-mediated Intracellular Signaling	16
The Role of Pro-fibrotic Myofibroblasts in Systemic Sclerosis: From Origin to Therapeutic Targeting	14
Quercetin: A Potential Candidate for the Treatment of Arthritis	14
Quercetin and its Relative Therapeutic Potential Against COVID-19: A Retrospective Review and Prospective Overview	13
Resveratrol Induces Apoptosis and Attenuates Proliferation of MCF-7 Cells in Combination with Radiation and Hyperthermia	13
Recent Advances in the Analysis Full/Empty Capsid Ratio and Genome Integrity of Adeno-associated Virus (AAV) Gene Delivery Vectors	13
Triazavirin - Potential Inhibitor for 2019-nCoV Coronavirus M Protease: A DFT Study	12
Lavender plant: Farming and Health benefits	12
Molecular Regulatory Roles of Long Non-coding RNA HOTTIP: An Overview in Gastrointestinal Cancers	12
Targeting Abnormal Nrf2/HO-1 Signaling in Amyotrophic Lateral Sclerosis: Current Insights on Drug Targets and Influences on Neurological Disorders	11
Role of Oxidative Stress and Antioxidant Supplementation in Male Fertility	11
NPC1 as a Modulator of Disease Severity and Viral Entry of SARSCoV- 2	11

Helicobacter pylori Biofilm and New Strategies to Combat it	10
Obesity and Insulin Resistance: A Review of Molecular Interactions	10
Hydroxycitric Acid Inhibits Renal Calcium Oxalate Deposition by Reducing Oxidative Stress and Inflammation	10
Human Recombinant Relaxin (Serelaxin) as Anti-fibrotic Agent: Pharmacology, Limitations and Actual Perspectives	10
Transcriptomic Signatures in Colorectal Cancer Progression	10
Metabolic Ink Lactate Modulates Epigenomic Landscape: A Concerted Role of Pro-tumor Microenvironment and Macroenvironment During Carcinogenesis	9
Regenerative Potential of Mesenchymal Stem Cell-Derived Extracellular Vesicles	9
Vitamin D and Non-coding RNAs: New Insights into the Regulation of Breast Cancer	9
The Role of Skin and Gut Microbiome and Epigenetic Modifications in Skin-Autoimmune Disorders	9
Metaxalone Suppresses Production of Inflammatory Cytokines Associated with Painful Conditions in Mouse Macrophages RAW264.7 Cells in Vitro: Synergistic Effect with β-caryophyllene	9
Targeting Tumor-derived Exosomes Expressing CD73: New Opportunities in the Pathogenesis and Treatment of Cancer	8
Hyaluronic Acid and Regenerative Medicine: New Insights into the Stroke Therapy	8
The Therapeutic Effect of Stem Cells on Chemotherapy-Induced Premature Ovarian Failure	8
OSI-027 Alleviates Oxaliplatin Chemoresistance in Gastric Cancer Cells by Suppressing P-gp Induction	8
ALK7 Inhibition Protects Osteoblast Cells Against High Glucoseinduced ROS Production via Nrf2/HO-1 Signaling Pathway	8
The Antitumor Effects of Icaritin Against Breast Cancer is Related to Estrogen Receptors	8
Wound Healing Properties of Exosomes — A Review and Modelling of Combinatorial Analysis Strategies	8
Ketogenic Diet: A Promising Neuroprotective Composition for Managing Alzheimer’s Diseases and its Pathological Mechanisms	8
Diabetic Neuropathy: Review on Molecular Mechanisms	8
Transcription Factors – the Essence of Heart Regeneration: A Potential Novel Therapeutic Strategy	7
Genome Editing with CRISPR-Cas9: A Budding Biological Contrivance for Colorectal Carcinoma Research and its Perspective in Molecular Medicine	7
The Emerging Role of LncRNA FENDRR in Multiple Cancers: A Review	7
An In vivo Immunohistochemical Study on MacroH2A.1 in Lung and Lymph-Node Tissues Exposed to an Asbestiform Fiber	7
The Prognostic Value of Cytokeratin and Extracellular Collagen Expression in Urinary Bladder Cancer	7
CD155: A Key Receptor Playing Diversified Roles	7
Chromosome 9 Inversion: Pathogenic or Benign? A Comprehensive Systematic Review of all Clinical Reports	7
Darolutamide as a Second-Generation Androgen Receptor Inhibitor in the Treatment of Prostate Cancer	7
Transcription Factors in Deriving β Cell Regeneration: A Potential Novel Therapeutic Target	7
SARS-CoV-2 Proteins: Are They Useful as Targets for COVID-19 Drugs and Vaccines?	7
Exosomes Harnessed as Nanocarriers for Cancer Therapy - Current Status and Potential for Future Clinical Applications	7
Cancer Immunology and CAR-T Cells: A Turning Point Therapeutic Approach in Colorectal Carcinoma with Clinical Insight	7
Cartilage Tissue and Therapeutic Strategies for Cartilage Repair	7
LncRNAs Roles in Chemoresistance of Cancer Cells	7
Targeting tumor hypoxia and hypoxia-inducible factors (HIFs) for the treatment of cancer- A story of transcription factors with novel approach in molecular medicine	6
Proteomics Profiling of Plasma Exosomes in VKH Patients	6
MicroRNAs Implications in the Onset, Diagnosis, and Prognosis of Osteosarcoma	6
Role of DACH1 on Proliferation, Invasion, and Apoptosis in Human Lung Adenocarcinoma Cells	6
The Regulatory Role of Pivotal MicroRNAs in the AKT Signaling Pathway in Breast Cancer	6
Vaccine Plasmid Topology Monitoring by Capillary Gel Electrophoresis	6
Intraocular Exosomes in Eye Diseases	6
Metabolomics Work Flow and Analytics in Systems Biology	6
Altered Expression of TRIM Proteins - Inimical Outcome and Inimitable Oncogenic Function in Breast Cancer with Diverse Carcinogenic Hallmarks	6
Heat Shock Proteins Regulating Toll-like Receptors and the Immune System could be a Novel Therapeutic Target for Melanoma	6
An Overview of the Latest Applications of Platelet-Derived Microparticles and Nanoparticles in Medical Technology 2010-2020	6
Combating the Progression of Novel Coronavirus SARS-CoV-2 Infectious Disease: Current State and Future Prospects in Molecular Diagnostics and Drug Discovery	6
The Roles of microRNAs in Multidrug-Resistance Mechanisms in Gastric Cancer	6
The Ineluctable Role of ACE-2 Receptors in SARS COV-2 Infection and Drug Repurposing as a Plausible SARS COV-2 Therapy: A Concise Treatise	5
Association of High-Mobility Group Box-1 with Inflammationrelated Cytokines in the Aqueous Humor with Acute Primary Angle-Closure Eyes	5
Current Progress on Neuroinflammation-mediated Postoperative Cognitive Dysfunction: An Update	5
A Review of DNA and Histone Methylation Alterations in the New Era of Diagnosis and Treatment of Retinal Diseases	5

Autophagy as an Anti-senescent in Aging Neurocytes	5
Sperm Mitochondria, the Driving Force Behind Human Spermatozoa Activities: Its Functions and Dysfunctions - A Narrative Review	5
N-glycomic Analysis of Z(IgA1) Partitioned Serum and Salivary Immunoglobulin A by Capillary Electrophoresis	5
Current Status of Alzheimer’s Disease and Pathological Mechanisms Investigating the Therapeutic Molecular Targets	5
COVID-19 and ARDS: Update on Preventive and Therapeutic Venues	5
High Plasmatic Levels of Advanced Glycation End Products are Associated with Metabolic Alterations and Insulin Resistance in Preeclamptic Women	5
CTLA-4: As an Immunosuppressive Immune Checkpoint in Breast Cancer	5
Ferroptosis and Cancer Immunotherapy	5
Cholesterol: A Prelate in Cell Nucleus and its Serendipity	5
Role of Innate Immune and Inflammatory Responses in the Development of Secondary Diabetic Complications	5
Cosmetic Fat Transplantation: A Review	5
Silencing of Long Non-coding RNA H19 Alleviates Lipopolysaccharide (LPS)-induced Apoptosis and Inflammation Injury by Regulating miR-140-5p/TLR4 Axis in Cell Models of Pneumonia	5
Critical Role of NFκB in the Pathogenesis of Non-alcoholic Fatty Liver Disease: A Widespread Key Regulator	5
Research Update on the Pathophysiological Mechanisms of Heart Failure with Preserved Ejection Fraction	5
Potential Involvement of Extracellular Citrate in Brain Tumor Progression	5
Aminooxy-Acetic Acid Inhibits Experimental Autoimmune Uveitis by Modulating the Balance between Effector and Regulatory Lymphocyte Subsets	5
SHMT2 is Associated with Tumor Purity, CD8+ T Immune Cells Infiltration, and a Novel Therapeutic Target in Four Different Human Cancers	5
Therapeutic Measures for the Novel Coronavirus: A Review of Current Status and Future Perspective	5
The Key Role of Akt Protein Kinase in Metabolic-Inflammatory Pathways Cross-Talk: TNF-α Down-Regulation and Improving of Insulin Resistance in HepG2 Cell Line	5
Combinatorial Chemosensitive Nanomedicine Approach for the Treatment of Breast Cancer	5
Cell-adhesion Molecules as Key Mechanisms of Tumor Invasion: The Case of Breast Cancer	5
Circular RNAs: Emerging Modulators in the Pathophysiology of Polycystic Ovary Syndrome and their Clinical Implications	5
MicroRNAs and their Implications in CD4+ T-cells, Oligodendrocytes and Dendritic Cells in Multiple Sclerosis Pathogenesis	4
Circular RNAs and Glioma: Small Molecule with Big Actions	4
MicroRNAs in Helminth Parasites: A Systematic Review	4
Peptide and Small Molecule Inhibitors Targeting Myeloid Cell Leukemia 1 (Mcl-1) as Novel Antitumor Agents	4
Cytokine Analysis in Patients with Different Stages of Thromboangiitis Obliterans	4
Epigenetic Reprogramming and Landscape of Transcriptomic Interactions: Impending Therapeutic Interference of Triple-Negative Breast Cancer in Molecular Medicine	4
Natural Products with Analgesic Effect from Herbs and Nutraceuticals Used in Traditional Chinese Medicines	4
Harnessing Drug Repurposing for Exploration of New Diseases: An Insight to Strategies and Case Studies	4
The Effect of Bacterial Composition Shifts in the Oral Microbiota on Alzheimer's Disease	4
Current Progress and Perspectives of CDC20 in Female Reproductive Cancers	4
Effects of MCU-mediated Ca2+ Homeostasis on Ovarian Cancer Cell SKOV3 Proliferation, Migration and Transformation	4
Role of Extracellular Vesicles in Alzheimer’s Disease: Current Advances	4
High Concentration of Dezocine Induces Immune Escape of Lung Cancer and Promotes Glucose Metabolism through Up-Regulating PD-L1 and Activating the NF-κB Pathway	4
Artemisia Species as a New Candidate for Diabetes Therapy: A Comprehensive Review	4
Cellular Functions of Small Heat Shock Proteins (HSPB) in Hepatocellular Carcinoma	4
Parathyroid Hormone-regulation of Runx2 by MiR-290 for Matrix Metalloproteinase-13 Expression in Rat Osteoblastic Cells	4
Extracellular Vesicles in Tumor Diagnosis: A Mini-Review	4
A Systematic Review of Potential Immunotherapies Targeting PRAME in Retinoid Resistant Oral Potentially Malignant Disorders and Oral Cancer	4
miR-141-3p Promotes the Cisplatin Sensitivity of Osteosarcoma Cell through Targeting the Glutaminase [GLS]-Mediated Glutamine Metabolism	4
A Comprehensive Review on Cross-talk of Human Papilloma Virus Oncoproteins and Developmental/Self-Renewal Pathways During the Pathogenesis of Uterine Cervical Cancer	4
Correlation Between Dexamethasone and miRNAs in the Regulation of Apoptosis, Drug-resistance, and Metastasis of Cancer Cell	4
Piwi-interacting RNAs (piRNAs) and Colorectal Carcinoma: Emerging Non-invasive diagnostic Biomarkers with Potential Therapeutic Target Based Clinical Implications	4
The Key Roles of Makorin RING Finger Protein 3 (MKRN3) During the Development of Pubertal Initiation and Central Precocious Puberty (CPP)	4
Melanocyte Adhesion and Apoptosis in Vitiligo: Linking Puzzle Blocks	4
Psoralidin Induced Differentiation from Adipose-derived Stem Cells to Nucleus Pulposus-like Cells by TGF-β/Smad Signaling	4
Gene Selection for the Discrimination of Colorectal Cancer	4