OOIR: Observatory of International Research

Papers

(The TQCC of Current Molecular Medicine is 5. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-08-01 to 2025-08-01.)

Article	Citations
NF-κB1 Intronic Region Polymorphisms as Risk Factor for Head and Neck Cancer in HPV-Infected Population from Pakistan	121
Pre-clinical Efficacy and Safety Pharmacology of PEGylated Recombinant Human Endostatin	38
USP3 inhibition is Active Against Chemo-resistant Hepatocellular Carcinoma Anchorage-independent Growth via Suppressing Wnt/β-catenin	38
Intracellular Ellagic Acid Derived from Goat Urine DMSO Fraction (GUDF) Predicted as an Inhibitor of c-Raf Kinase	32
Aberrant β-catenin Activity in Hepatoid Adenocarcinoma of the Stomach	29
Transcription Factors in Deriving β Cell Regeneration: A Potential Novel Therapeutic Target	29
Attenuation of NLRP3 Inflammasome by Cigarette Smoke is Correlated with Decreased Defense Response of Oral Epithelial Cells to Candida albicans	27
In Transfusion-Dependent Thalassemia Children, Increased Iron Overload is Associated with Lower Serum Alpha-Klotho, Which is Strongly Associated with Lower Total and Ionized Calcium Concentrations	26
Altered Expression of TRIM Proteins - Inimical Outcome and Inimitable Oncogenic Function in Breast Cancer with Diverse Carcinogenic Hallmarks	24
Free Radicals and Oxidative Stress: Signaling Mechanisms, Redox Basis for Human Diseases, and Cell Cycle Regulation	23
Epigenetic Mechanisms of Antibiotic Resistance	21
Sodium Butyrate Pre-Treatment Enhance Differentiation of Bone Marrow Mesenchymal Stem Cells (BM-MSCs) into Hepatocytes and Improve Liver Injury	21
Human Recombinant Relaxin (Serelaxin) as Anti-fibrotic Agent: Pharmacology, Limitations and Actual Perspectives	18
Diet-induced Obesity Differentially Modulates Cardiac Inflammatory Status in the C57 and FVB Mouse Strains	17
CRISPR-Cas9: A Potent Gene-editing Tool for the Treatment of Cancer	17
Ferroptosis and Cancer Immunotherapy	17
A Mini-Review on Elisa-Based Diagnosis of Schistosomiasis	16
COL12A1 Promotes Osteosarcoma Progression via the FAK/PI3K/AKT/mTOR Pathway	15
NLRP3 Inflammasome Triggers Inflammation of Obstructive Sleep Apnea	15
The Importance of mir-491-5p in Various Cancers	14
Anlotinib Inhibiting Mantle Cell Lymphoma Proliferation and Inducing Apoptosis through PI3K/AKT/mTOR Pathway	14
CD4⁺ T-cell Subsets and Cytokine Signature in Pemphigus Foliaceus Clinical Stratification beyond the th1/Th2 Paradigm	14
Targeting ADAM10 in Renal Diseases	13
Reduction of ACE2 Serum Concentrations by Telbivudine in Chronic Hepatitis B Patients	13
The Role of the TRIM Family in Lung Cancer Development: An Emerging Player with Therapeutic Potential	13

An Insight into Novel Sperm Cell Proteins as Bio-markers for Male Infertility: A Review	13
MicroRNA-Based Biomarkers in Lung Cancer: Recent Advances and Potential Applications	13
An Updated Review of the Pre-Clinical Role of microRNAs and their Contribution to Colorectal Cancer	13
High Glycolysis and Lipid Metabolism Status Predicts Poor Prognosis in Colorectal Cancer Patients	12
Potential Roles of 5-HT₃ Receptor Antagonists in Reducing Chemotherapy-induced Peripheral Neuropathy (CIPN)	12
SMAC/DIABLO: A Guardian Angel in Boosting Anticancer Drug-Induced Apoptosis	12
Follicular Helper T Cells in Peyer's Patches and Galactose- Deficient Iga1 Contribute to Iga Nephropathy	12
Structural and Pharmacological Network Focused on MiRNAs Involved in Rheumatoid Arthritis: A Systematic Review	12
Study on the Mechanism of Notch Pathway Mediates the Role of Lenvatinib-resistant Hepatocellular Carcinoma Based on Organoids	12
Ribosomal DNA and Neurological Disorders	12
ERK/MAPK Signalling Pathway Regulates MMP2 through ETS1 in Renal Clear Cell Carcinoma	12
Recombinant Unique Cartilage Matrix-associated Protein Potentiates Osteogenic Differentiation and Mineralization of MC3T3-E1 Cells	11
Loss of ARHGAP40 in Breast Cancer by Hypermethylation and its Clinical Significance	11
Novel Insights of ANGPTL-3 on Modulating Cholesterol Efflux Capacity Induced by HDL Particle	11
Physicochemical Stimulus-Responsive Systems Targeted with Antibody Derivatives	11
The Mechanosensitive Ion Channel Piezo1 Promotes Obliterative Bronchiolitis through YAP-Dependent Epithelial-to-Mesenchymal Transition	11
A Mechanism Study on the Antioxidant Pathway of Keap1-Nrf2- ARE Inhibiting Ferroptosis in Dopaminergic Neurons	11
Update on Mesenchymal Stem Cells: A Crucial Player in Cancer Immunotherapy	11
LKB1 Mutations Enhance Radiosensitivity in Non-Small Cell Lung Cancer Cells by Inducing G2/M Cell Cycle Phase Arrest	10
CD155: A Key Receptor Playing Diversified Roles	10
DFT Study of Interaction between Teriflunomide and β-cyclodextrin	10
Detailed Review of Melatonin and its Role in Managing the Symptoms of Depression	10
Combating the Progression of Novel Coronavirus SARS-CoV-2 Infectious Disease: Current State and Future Prospects in Molecular Diagnostics and Drug Discovery	10
The Emerging Role of Long Non-Coding RNA 01296 in Human Malignancies	10
CsHscB Derived from a Liver Fluke Clonorchis sinensis Ameliorates Cholestatic Hepatic Fibrosis in a Mouse Model of Sclerosing Cholangitis	10
Enhancement of Platinum-Based Drug Sensitivity in Ovarian Cancer Cells Through Hyperthermia-Induced Activation of the TGF-β1/β-Catenin Signaling Pathway	10
Clock-Sleep Communication	9
Triazavirin - Potential Inhibitor for 2019-nCoV Coronavirus M Protease: A DFT Study	9
Role of MicroRNA in Hypoxic Tumours and their Potential as Biomarkers for Early Detection of Cancer	9
Glaucoma: Biological Mechanism and its Clinical Translation	9
HMGB1/RAGE Signaling Regulates Th17/IL-17 and Its Role in Bronchial Epithelial-Mesenchymal Transformation	9
The Role of Hypoxia-inducible Factor-1 in Bladder Cancer	9
The Diagnostic and Prognostic Value of Plasma Circulating CircNUP98 for Nasopharyngeal Carcinoma	9
Dexmedetomidine Attenuates Spinal Cord Ischemia-reperfusion Injury in Rabbits by Decreasing Oxidation and Apoptosis	9
LINC00665: A Promising Biomarker in Gastrointestinal Tumors	9
Exploring the Gut Microbiota as a Promising Target for Breast Cancer Treatment	9
Pharmacological Activation of AMPK Prevents Drp1-mediated Mitochondrial Fission and Alleviates Hepatic Steatosis In vitro	8
Natural Compounds as Integrative Therapy for Liver Protection against Inflammatory and Carcinogenic Mechanisms: From Induction to Molecular Biology Advancement	8
Time- and Concentration-Dependent Stimulation of Oxidative Stress in Chondrocytes by Intracellular Soluble Urate	8
Association between Sputum Culture Conversion and Body Mass Index among Multidrug-Resistant Tuberculosis Patients in Punjab, Pakistan: A Multicenter Retrospective Study	8
Immunohistochemical Analysis of CYP11B2 (Aldosterone Synthase) and Evaluation of the HISTALDO Classification in Patients with Primary Aldosteronism	8
Neuroprotective Potential of Hesperidin as Therapeutic Agent in the Treatment of Brain Disorders: Preclinical Evidence-based Review	8
Astragaloside IV Protects Against IL-1β-Induced Chondrocyte Damage via Activating Autophagy	8
Interferon Signature’s Members, a Novel Altered Correlation upon Interferon-β Treatment in Multiple Sclerosis Patients	8
Inducing Tumor Cell Apoptosis: Mediated Survivin miRNA by Ultrasound and Cationic Lipid Contrast Agent	8
Hydroxysafflor Yellow A-Induced Osteoblast Differentiation and Proliferation of BM-MSCs by Up-Regulating Nuclear Vitamin D Receptor	8
Stem Cells as a Novel Source for Regenerative Medicinal Applications in Alzheimer's Disease: An Update	8
Hypoxia Affects Mitochondrial Stress and Facilitates Tumor Metastasis of Colorectal Cancer Through Slug SUMOylation	8
Targeting Abnormal Nrf2/HO-1 Signaling in Amyotrophic Lateral Sclerosis: Current Insights on Drug Targets and Influences on Neurological Disorders	8
Multiplex PCR System for the Diagnosis of Plague	8

Elucidating the Causal Dynamics between Inflammatory Proteins and Atrial Fibrillation Risk Through Bidirectional Mendelian Randomization	8
MicroRNAs Implications in the Onset, Diagnosis, and Prognosis of Osteosarcoma	8
2-DG Promotes the Proliferation, Differentiation, Migration, and Resistance to Oxidative Stress of Mesenchymal Stem Cells through Hippo Signaling	8
Asiaticoside Prevents Oxidative Stress and Apoptosis in Endothelial Cells by Activating ROS-dependent p53/Bcl-2/Caspase-3 Signaling Pathway	7
Molecular Targeting and Novel Therapeutic Approaches against Fungal Infections	7
Bioprinting: From Technique to Application in Tissue Engineering and Regenerative Medicine	7
Reversal of Mucin 1 Reduction-Induced Enterocyte Apoptosis by Retinoic Acid through the PI3K/AKT Signaling Pathway in an In vitro Model of Necrotizing Enterocolitis	7
An Overview of Invasive Ductal Carcinoma (IDC) in Women’s Breast Cancer	7
Analysis of Cytokine mRNA Expression During Zika Virus Infection In Mesocricetus auratus	7
ORLNC1 Suppresses Cell Growth in HER2-Positive Breast Cancer via miRNA-296 Sponging	7
Apolipoprotein A1 Inhibits Adipogenesis Progression of Human Adipose-Derived Mesenchymal Stem Cells	7
Altered Expression of microRNAs in Serum Extracellular Vesicles in Rats with Severe Burns during Shock Stage	7
LncRNA-DANCR: A Key Player in Colorectal Cancer Development and Progression	7
Leukaemia Infection Diagnosis and Intestinal Flora Disorder	7
Proteomics Profiling of Plasma Exosomes in VKH Patients	7
Mesenchymal Stem Cell-derived Exosomes Affect Macrophage Phenotype: A Cell-free Strategy for the Treatment of Skeletal Muscle Disorders	7
Neuroprotective Role of MiRNA-9 in Neurological Diseases: A Mini Review	7
The Diverse Roles of Long Non-Coding RNA HOTTIP in Breast and Gynecological Cancer Progression	7
Genetic Association Between Sleep Traits and Vertigo Risk: A Two-Sample Bidirectional Mendelian Randomization Study	7
Investigation of the Anti-Cancer Effects of Free and PLGA-PAA Encapsulated Hydroxytyrosol on the MCF-7 Breast Cancer Cell Line	6
Nuclear Imaging Modalities in the Diagnosis and Management of Thyroid Cancer	6
Targeting Ubiquitin-specific Protease 5 Overcomes Chemoresistance via Negatively Regulating p53 in Gastric Cancer	6
Iron Overload-induced Ferroptosis as a Target for Protection against Obliterative Bronchiolitis after Orthotopic Tracheal Transplantation in Mice	6
Current Progress on Neuroinflammation-mediated Postoperative Cognitive Dysfunction: An Update	6
WITHDRAWN: LncRNA-PVT1 Inhibition Protects Neuron Injury During Cerebral Ischemia Injury through Targeting the miRNA-187-3p- MyD88 Signaling Pathway	6
Emerging Treatment Approaches for COVID-19 Infection: A Critical Review	6
CXCL13-neutralizing Antibody Alleviate Chronic Skeletal Muscle Degeneration in a Mouse Model	6
Aptamers for Brain Tumors: A Therapeutic Agent for Effectively Crossing the Blood-Brain Barrier	6
Protein PDK4 Interacts with HMGCS2 to Facilitate High Glucoseinduced Myocardial Injuries	6
Advances in Exosomal microRNAs and Proteins in Ovarian Cancer Diagnosis, Prognosis, and Treatment	6
Role of Mitophagy in Cigarette Smoke-induced Lung Epithelial Cell Injury In Vitro	6
The Marine Factor 3,5-dihydroxy-4-methoxybenzyl Alcohol Suppresses Cell Growth, Inflammatory Cytokine Production, and NF-κB Signaling-enhanced Osteoclastogenesis in In vitro Mouse Macrophages RAW264.7	6
Peptide and Small Molecule Inhibitors Targeting Myeloid Cell Leukemia 1 (Mcl-1) as Novel Antitumor Agents	6
MicroRNAs in the Pathogenesis of Ankylosing Spondylitis and their Clinical Implication	6
The Association between Cadmium Exposure and Thyroid Function in Animals: A Systematic Review	6
miR-34 as a Critical Regulator in Ovarian Cancer	6
Advances in Molecular Biology and Immunology of Spermatozoa and Fertilization in Domestic Animals: Implications for Infertility and Assisted Reproduction	6
Ferroptosis Inhibitor Regulates the Disease Progression of Systematic Lupus Erythematosus Mice Model Through Th1/Th2 Ratio	6
Advances in the Study of the Pathogenesis of Vogt-Koyanagi-Harada Syndrome	6
The Apoptotic, Cytotoxic, and Anti-migration Effects of Sodium Deoxycholate in a Breast Cancer Cell Line and its Modulation on PON1 as a Predictive Risk Marker	6
The Potential Therapeutic Applications of CRISPR/Cas9 in the Treatment of Gastrointestinal Cancers	6
Combinatorial Chemosensitive Nanomedicine Approach for the Treatment of Breast Cancer	6
Bioactive Loaded Lipid-based Nanostructures: A Novel Insight for Age-related Neurodegeneration	6
Crocetin Suppresses Uterine Ischemia/Reperfusion-induced Inflammation and Apoptosis through the Nrf-2/HO-1 Pathway	6
Microhomology-Mediated Break-Induced Replication: A Possible Molecular Mechanism of the Formation of a Large CNV in FBN1 Gene in a Patient with Marfan Syndrome	5
Therapeutic Challenges in COVID-19	5
The Role of Bone Morphogenetic Protein 4 in Lung Diseases	5
Research Update on the Pathophysiological Mechanisms of Heart Failure with Preserved Ejection Fraction	5
Understanding the Roles of Non-coding RNAs and Exosomal Non-Coding RNAs in Diabetic Nephropathy	5
Loperamide-induced Constipation Activates Inflammatory Signaling Pathways in the Mid Colon of SD Rats Via Complement C3 and its Receptors	5
Covid-19 Prevention and Treatment by Targeting Fc-fusion Proteins: An Experience to Fight Emerging Diseases	5
Erucic Acid: A Possible Therapeutic Agent for Neurodegenerative Diseases	5
Advances in Monoclonal Antibody Therapies for Triple-Negative Breast Cancer: Immunotherapeutic and Targeted Strategies	5
Neurodegenerative Diseases: New Hopes and Perspectives	5
Preface	5
Immune Mechanisms and Related Targets for the Treatment of Fibrosis in Various Organs	5
ATF3 Modulates the Proliferation, Migration, and Apoptosis of Synovial Fibroblasts after Arthroscopy by Promoting RGS1 Transcription	5
WITHDRAWN: Nucleic Acid-Based Vaccines Platform Against Covid-19 Pandemic	5
Molecular Mechanisms of miR-214 Involved in Cancer and Drug Resistance	5
The Determinative Role of Cytokines in Retinopathy of Prematurity	5
TPD52 is a Potential Prognostic Biomarker and Correlated with Immune Infiltration: A Pan-cancer Analysis	5
Development of Tumor Markers for Breast Cancer Immunotherapy	5
The Role of Retinoblastoma Protein in Cell Cycle Regulation: An Updated Review	5
Analysis of Alternative Splicing Events in Melanoma and their Implications for Prognosis	5
Endothelial Progenitor Cell (EPC) is a Prime Target in Diabetic Wound Healing: Mechanisms and Target Therapies	5
Exosomes Harnessed as Nanocarriers for Cancer Therapy - Current Status and Potential for Future Clinical Applications	5
M1 Macrophage-Derived TNF-α Promotes Pancreatic Cancer Ferroptosis Via p38 MAPK-ACSL4 Pathway	5
Gut Microbiota-Induced Long Non-Coding RNA Snhg9 Regulates the Development of Human Malignant Tumors	5
Quercetin: A Potential Candidate for the Treatment of Arthritis	5
An Overview of the Latest Applications of Platelet-Derived Microparticles and Nanoparticles in Medical Technology 2010-2020	5
Ionizing Radiation Combined with Gold Complex Compounds Causes Apoptosis in Colorectal Cancer Cells by Increasing the Level of Caspase-3	5
Elevation of LEM Domain Containing 1 Predicts Poor Prognosis of NSCLC Patients and Triggers Malignant Stemness and Invasion of NSCLC Cells by Stimulating PI3K/AKT Pathway	5
MicroRNAs and their Implications in CD4+ T-cells, Oligodendrocytes and Dendritic Cells in Multiple Sclerosis Pathogenesis	5
Oxidative Stress is a New Avenue for Treatment of Neuropsychiatric Disorders: Hype of Hope?	5
Evaluation of the Safety and Efficacy of Curcumin-Synthesized Silver Nanoparticles in Rats Exposed to Chlorpyrifos During Puberty Development	5