OOIR: Observatory of International Research

Papers

(The TQCC of Current Alzheimer Research is 5. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2020-05-01 to 2024-05-01.)

Article	Citations
MRI Radiomics Classification and Prediction in Alzheimer’s Disease and Mild Cognitive Impairment: A Review	47
CREB: A Multifaceted Target for Alzheimer’s Disease	46
Association Between Oxidative Stress and Altered Cholesterol Metabolism in Alzheimer’s Disease Patients	29
Exploring Shared Pathogenesis of Alzheimer’s Disease and Type 2 Diabetes Mellitus via Co-expression Networks Analysis	26
The Association between TNF-alpha, IL-1 alpha and IL-10 with Alzheimer's Disease	23
LncRNA Xist, X-chromosome Instability and Alzheimer’s Disease	23
Genetic Variants and Oxidative Stress in Alzheimer’s Disease	23
Mechanisms of Anticholinesterase Interference with Tau Aggregation Inhibitor Activity in a Tau-Transgenic Mouse Model	21
Accelerated Epigenetic Aging in Peripheral Blood does not Predict Dementia Risk	20
Neuroprotective Effect of Fucoxanthin against Intracerebroventricular Streptozotocin (ICV-STZ) Induced Cognitive Impairment in Experimental Rats	20
Effect of High Cholesterol Regulation of LRP1 and RAGE on Aβ Transport Across the Blood-Brain Barrier in Alzheimer’s Disease	19
Diagnosis of Mild Cognitive Impairment Using Cognitive Tasks: A Functional Near-Infrared Spectroscopy Study	18
Reversal of Calcium Dysregulation as Potential Approach for Treating Alzheimer's Disease	18
Multi-Target Directed Ligands (MTDLs): Promising Coumarin Hybrids for Alzheimer’s Disease	18
Current Challenges and Limitations in the Studies of Intrinsically Disordered Proteins in Neurodegenerative Diseases by Computer Simulations	17
Self-defining Memories and their Contribution to the Sense of Self in Alzheimer’s Disease	15
Cerebrospinal Fluid and Blood CX3CL1 as a Potential Biomarker in Early Diagnosis and Prognosis of Dementia	15
Accuracy of Telephone-Based Cognitive Screening Tests: Systematic Review and Meta-Analysis	15
Research Progress on circRNA in Nervous System Diseases	15
An Effective Brain Imaging Biomarker for AD and aMCI: ALFF in Slow-5 Frequency Band	15
Alterations in Mitochondrial Dynamic-related Genes in the Peripheral Blood of Alzheimer’s Disease Patients	15
Non-steroidal Anti-inflammatory Drugs as Candidates for the Prevention or Treatment of Alzheimer’s Disease: Do they Still Have a Role?	14
Investigation of Low Dose Cabazitaxel Potential as Microtubule Stabilizer in Experimental Model of Alzheimer's Disease: Restoring Neuronal Cytoskeleton	14
Risk Reduction and Prevention of Alzheimer's Disease: Biological Mechanisms of Diet	13
Curcumin Prevents Neuroinflammation by Inducing Microglia to Transform into the M2-phenotype via CaMKKβ-dependent Activation of the AMP-Activated Protein Kinase Signal Pathway	13

Targeting Pathological Amyloid Aggregates with Conformation-Sensitive Antibodies	13
Association of Circulating Cholesterol Level with Cognitive Function and Mild Cognitive Impairment in the Elderly: A Community-based Population Study	13
Volumetric MRI Demonstrates Atrophy of the Olfactory Cortex in AD	13
Comparative Efficacy and Acceptability of Cholinesterase Inhibitors and Memantine Based on Dosage in Patients with Vascular Cognitive Impairment: A Network Meta-analysis	13
Mitochondrial Calcium Signaling as a Therapeutic Target for Alzheimer’s Disease	12
Dangerous Liaisons: Tau Interaction with Muscarinic Receptors	12
Cerebral Microbleeds and White Matter Hyperintensities are Associated with Cognitive Decline in an Asian Memory Clinic Study	12
A Conceptual Framework for Research on Cognitive Impairment with no Dementia in Memory Clinic	12
Anti-Neurodegenerative Benefits of Acetylcholinesterase Inhibitors in Alzheimer’s Disease: Nexus of Cholinergic and Nerve Growth Factor Dysfunction	12
Low Intensity Electromagnetic Fields Act via Voltage-Gated Calcium Channel (VGCC) Activation to Cause Very Early Onset Alzheimer’s Disease: 18 Distinct Types of Evidence	12
Microglia and its Genetics in Alzheimer's Disease	11
Cytokine Storm and Neuropathological Alterations in Patients with Neurological Manifestations of COVID-19	11
The Alzheimer’s Disease Amyloid Precursor Protein and its Neuritogenic Actions	11
Effects of Spices (Saffron, Rosemary, Cinnamon, Turmeric and Ginger) in Alzheimer's Disease	11
Impaired Cognitive Function is Associated with Motor Function and Activities of Daily Living in Mild to Moderate Alzheimer's Dementia	11
Weight Loss and the Risk of Dementia: A Meta-analysis of Cohort Studies	10
Unfolded p53 as a Marker of Oxidative Stress in Mild Cognitive Impairment, Alzheimer’s and Parkinson’s Disease	10
Metabolic Syndrome, Alzheimer’s Disease, and Covid 19: A Possible Correlation	10
Relationship of Neurofilament Light (NfL) and Cognitive Performance in a Sample of Mexican Americans with Normal Cognition, Mild Cognitive Impairment and Dementia	9
Carotid Arterial Stiffness and Cerebral Blood Flow in Amnestic Mild Cognitive Impairment	9
Amyloid-beta Induced Neurotoxicity Impairs Cognition and Adult Hippocampal Neurogenesis in a Mouse Model for Alzheimer’s Disease	9
Association of Dietary Prebiotic Consumption with Reduced Risk of Alzheimer’s Disease in a Multiethnic Population	9
The Relationship of Anxiety with Alzheimer’s Disease: A Narrative Review	9
Degradation Products of Amyloid Protein: Are They The Culprits?	8
Neuroprotector Effect of Daily 8-Minutes of High-Intensity Interval Training in Rat Aβ1-42 Alzheimer Disease Model	8
IL-8 and MCP-1 Impact on Tau Phosphorylation and Phosphatase Activity	8
Anticholinesterase and Antioxidant Activities of Natural Abietane Diterpenoids with Molecular Docking Studies	8
The Contribution of Cerebral Vascular Neuropathology to Mild Stage of Alzheimer’s Dementia Using the NACC Database	8
Serine Racemase Expression Differentiates Aging from Alzheimer’s Brain	8
Mitochondrial Dysfunction as a Causative Factor in Alzheimer’s Disease-Spectrum Disorders: Lymphocytes as a Window to the Brain	8
Approaches to Optimizing Dantrolene Neuroprotection for the Treatment of Alzheimer's Disease	8
Non-Ceruloplasmin Copper as a Stratification Biomarker of Alzheimer’s Disease Patients: How to Measure and Use It	8
Electromagnetic Field in Alzheimer’s Disease: A Literature Review of Recent Preclinical and Clinical Studies	8
Inflammation in Alzheimer’s Disease	8
Alzheimer’s Disease and its Related Dementia Types: A Review on Their Management Via Nanotechnology Based Therapeutic Strategies	8
Huntingtin Levels are Elevated in Hippocampal Post-Mortem Samples of Alzheimer’s Disease Brain	8
RAGE Isoforms, its Ligands and their Role in Pathophysiology of Alzheimer’s Disease	8
The Relationship between Social Cognition and Executive Functions in Alzheimer’s Disease: A Systematic Review	8
Mitochondrially-Targeted Therapeutic Strategies for Alzheimer’s Disease	8
Robust Discovery of Mild Cognitive Impairment Subtypes and Their Risk of Alzheimer's Disease Conversion Using Unsupervised Machine Learning and Gaussian Mixture Modeling	8
Neuroimaging Outcomes in Studies of Cognitive Training in Mild Cognitive Impairment and Early Alzheimer’s Disease: A Systematic Review	8
Identification of Somatic Mutations in Dementia-related Genes in Cancer Patients	7
β-Amyloid is an Immunopeptide and Alzheimer’s is an Autoimmune Disease	7
Polymorphism Rs2421943 of the Insulin-Degrading Enzyme Gene and the Risk of Late-Onset Alzheimer’s Disease	7
Dihydroartemisinin Ameliorates Decreased Neuroplasticity-Associated Proteins and Excessive Neuronal Apoptosis in APP/PS1 Mice	7
Codonopsis pilosula Polysaccharides Alleviate Aβ1-40-Induced PC12 Cells Energy Dysmetabolism via CD38/NAD+ Signaling Pathway	7
Astrocyte Reactivity in Alzheimer’s Disease: Therapeutic Opportunities to Promote Repair	7
Neutrophil Granule Proteins Inhibit Amyloid Beta Aggregation and Neurotoxicity	7
Mild Behavioral Impairment: An Early Sign and Predictor of Alzheimer's Disease Dementia	7
High Fat Diet Aggravates AD-Related Pathogenic Processes in APP/PS1 Mice	6

Risk Factors for Alzheimer’s Disease: An Epidemiological Study	6
Automatic Assessment of Cognitive Tests for Differentiating Mild Cognitive Impairment: A Proof of Concept Study of the Digit Span Task	6
Association between Matrix Metalloproteinases, Their Tissue Inhibitor and White Matter Lesions in Mild Cognitive Impairment	6
Development and Validation of a Model to Identify Alzheimer’s Disease and Related Syndromes in Administrative Data	6
Inflammatory Biomarkers in AD: Implications for Diagnosis	6
Heterogeneity of Tau Deposition and Microvascular Involvement in MCI and AD	6
Parkinson’s Symptoms and Caregiver Affiliate Stigma: A Multinational Study	6
Impairment of Store-operated Calcium Entry: Implications in Alzheimer’s Neurodegeneration	6
Enhanced Anti-Amyloid Effect of Combined Leptin and Pioglitazone in APP/PS1 Transgenic Mice	6
Microglial Store-operated Calcium Signaling in Health and in Alzheimer’s Disease	6
Functional Connectivity Alterations Based on the Weighted Phase Lag Index: An Exploratory Electroencephalography Study on Alzheimer’s Disease	6
Melatonin Prevents Neddylation Dysfunction in Aβ42-Exposed SH-SY5Y Neuroblastoma Cells by Regulating the Amyloid Precursor Protein- Binding Protein 1 Pathway	6
Clinical, Neuropsychological, and Neuroimaging Characteristics of Amyloid- positive vs. Amyloid-negative Patients with Clinically Diagnosed Alzheimer’s Disease and Amnestic Mild Cognitive Impairment	6
Evaluation and Prediction of Early Alzheimer’s Disease Using a Machine Learning-based Optimized Combination-Feature Set on Gray Matter Volume and Quantitative Susceptibility Mapping	6
Mechanistic Modeling of Soluble Aβ Dynamics and Target Engagement in the Brain by Anti-Aβ mAbs in Alzheimer’s Disease	6
Association Serum S100B Protein in Alzheimer’s Disease: A Case Control Study from South India	6
Hippocampal and Amygdalar Morphological Abnormalities in Alzheimer’s Disease Based on Three Chinese MRI Datasets	5
Theracurmin Supplementation May be a Therapeutic Option for Older Patients with Alzheimer’s Disease: A 6-Month Retrospective Follow-Up Study	5
Rectifying Attenuated Store-Operated Calcium Entry as a Therapeutic Approach for Alzheimer’s Disease	5
A Comprehensive Investigation of Molecular Signatures and Pathways Linking Alzheimer’s Disease and Epilepsy via Bioinformatic Approaches	5
The Parietal Atrophy Score on Brain Magnetic Resonance Imaging is a Reliable Visual Scale	5
Palmitoylated Prolactin-releasing Peptide Reduced Aβ Plaques and Microgliosis in the Cerebellum: APP/PS1 Mice Study	5
Poststroke Cognitive Impairment: A Longitudinal Follow-Up and Pre/Poststroke Mini-Mental State Examination Comparison	5
Risk Assessment During Longitudinal Progression of Cognition in Older Adults: A Community-based Bayesian Networks Model	5
A Novel Probiotic Formula, BIOCG, Protects Against Alzheimer’s-Related Cognitive Deficits via Regulation of Dendritic Spine Dynamics	5
The Gut Microbiome and Alzheimer’s Disease: A Growing Relationship	5
A Comparison of Neurocognitive Decline in Older Adults in Same-Sex and Opposite-Sex Relationships	5
Digital Intervention for the Management of Alzheimer’s Disease	5
Acting Before; A Combined Strategy to Counteract the Onset and Progression of Dementia	5
A Comparison of Two Statistical Mapping Tools for Automated Brain FDG-PET Analysis in Predicting Conversion to Alzheimer’s Disease in Subjects with Mild Cognitive Impairment	5
Retinal Changes in Transgenic Mouse Models of Alzheimer’s Disease	5
Clinical Phenotype and Mutation Spectrum of Alzheimer’s Disease with Causative Genetic Mutation in a Chinese Cohort	5
Exendin-4 Improves Cognitive Function of Diabetic Mice via Increasing Brain Insulin Synthesis	5
Connectivity and Patterns of Regional Cerebral Blood Flow, Cerebral Glucose Uptake, and Aβ-Amyloid Deposition in Alzheimer's Disease (Early and Late-Onset) Compared to Normal Ageing	5
Genetic Editing and Pharmacogenetics in Current And Future Therapy Of Neurocognitive Disorders	5
From Infection to Inoculation: Expanding the Microbial Hypothesis of Alzheimer’s Disease	5
Effects of Supplementation with Probiotics in Experimental Models of Alzheimer's Disease: A Systematic Review of Animal Experiments	5