OOIR: Observatory of International Research

Papers

(The TQCC of Current Alzheimer Research is 5. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-04-01 to 2025-04-01.)

Article	Citations
β-Amyloid is an Immunopeptide and Alzheimer’s is an Autoimmune Disease	29
A Cross-Sectional Study on the Association between Physical Activity and Cognitive Function Among Community-Dwelling Older Adults in Tianjin	27
Multimodal Gamma Stimulation Improves Activity but not Memory in Aged Tgf344-AD Rats	26
Multi-Target Directed Ligands (MTDLs): Promising Coumarin Hybrids for Alzheimer’s Disease	20
Toxic Advanced Glycation End-Products-Dependent Alzheimer’s Disease- Like Alternation in the Microtubule System	19
Blink Rate Study in Patients with Alzheimer's Disease, Mild Cognitive Impairment and Subjective Cognitive Decline	19
Real-world Utilisation of the Rivastigmine Transdermal Patches Accompanying the Use of Risk Minimisation Tools in Patients with Dementia	19
Acknowledgements to Reviewers	19
Research Progress of Eye Movement Analyses and its Detection Algorithms in Alzheimer’s Disease	18
Functional Roles of Neuronal Nitric Oxide Synthase in Neurodegenerative Diseases and Mood Disorders	17
Recent Updates on Alzheimer’s Disease: Pathogenesis, Pathophysiology, Molecular Approaches and Natural Bioactive Compounds Used in Contemporary Time to Alleviate Disease	16
A Timeline of Ca2+/cAMP Signalling: From Basic Research to Potential Therapeutics for Dementia	15
The Postoperative Effects of Anesthesia Exposure on Cognitive Decline in Older Adults: A Narrative Review	15
Acetyl-L-Carnitine Aids in Preservation of Cholinergic Neurons and Memory in the Drosophila melanogaster Model of Alzheimer's Disease	15
Molecular Mechanisms of GFAP and PTPRC in Alzheimer's Disease: An Analysis of Neuroinflammatory Response and Progression	13
Associations between Physical Performance Tests with Cognitive Changes: The Moderating Effect of Cognitive Status	13
Retinal Changes in Transgenic Mouse Models of Alzheimer’s Disease	12
The Need for a Break	12
Cognitive Versus Hemorrhagic Onset in Cerebral Amyloid Angiopathy: Neuroimaging Features	12
Visualization Analysis of Tau Protein in the Brain of Alzheimer’s Disease: A Scoping Literature Review	12
Poststroke Cognitive Impairment: A Longitudinal Follow-Up and Pre/Poststroke Mini-Mental State Examination Comparison	11
In vitro Aggregation Ability of Five Commercially Available Aβ42 peptide	11
Neurodegeneration and Glial Activation Related CSF Biomarker as the Diagnosis of Alzheimer’s Disease: A Systematic Review and an Updated Meta- analysis	11
Uncovering the Impact of Aggrephagy in the Development of Alzheimer's Disease: Insights Into Diagnostic and Therapeutic Approaches from Machine Learning Analysis	10
MicroRNA-125a-3p Modulate Amyloid β-Protein through the MAPK Pathway in Alzheimer’s Disease	10

Early Chronic Stress Induced Changes within the Locus Coeruleus in Sporadic Alzheimer’s Disease	10
White Matter Damage in Alzheimer’s Disease: Contribution of Oligodendrocytes	9
Comparative Bioavailability Study of a Novel Multi-Day Patch Formulation of Rivastigmine (Twice Weekly) with Exelon® Transdermal Patch (Daily)- A Randomized Clinical Trial	9
Disrupted White Matter Networks from Subjective Memory Impairment to Amnestic Mild Cognitive Impairment	9
Drug Design for Alzheimer’s Disease: Biologics vs. Small Molecules	9
Effects of Metformin on Modulating the Expression of Brain-related Genes of APP/PS1 Transgenic Mice based on Single Cell Sequencing	8
Functional Connectivity Alterations Based on the Weighted Phase Lag Index: An Exploratory Electroencephalography Study on Alzheimer’s Disease	8
Microglia PTK2B/Pyk2 in the Pathogenesis of Alzheimer’s Disease	8
Construction of lncRNA-ceRNA Networks to Reveal the Potential Role of Lfng/Notch1 Signaling Pathway in Alzheimer’s Disease	8
Human microRNA-4433 (hsa-miR-4443) Targets 18 Genes to be a Risk Factor of Neurodegenerative Diseases	8
Behavioural Variant Frontotemporal Dementia due to CCNF Gene Mutation: A Case Report	8
Risk Assessment During Longitudinal Progression of Cognition in Older Adults: A Community-based Bayesian Networks Model	8
Bloodborne Pancreatic Amylin, a Therapeutic Target for Alzheimer's Disease	8
Role of Inflammatory Cytokines in the Conversion of Mild Cognitive Impairment to Dementia: A Prospective Study	8
Codonopsis pilosula Polysaccharides Alleviate Aβ1-40-Induced PC12 Cells Energy Dysmetabolism via CD38/NAD+ Signaling Pathway	8
Early Memory Impairment is Accompanied by Changes in GluA1/ p-GluA1 in APP/PS1 Mice	8
Association of Dietary Habits with Mild Cognitive Impairment among Elderly in Rural Area of North China	8
Kappa/Lambda light-chain typing in Alzheimer’s Disease	8
Clinical Application of the Vestibular Stimulation Effect on Balance Disorders with Dementia	8
Weight Loss and the Risk of Dementia: A Meta-analysis of Cohort Studies	8
The Association between Vitamin D Deficiency and Changes in Cognitive Functions in Chinese Older Adults: A Prospective Cohort Study	7
Poloxamer-188 Exacerbates Brain Amyloidosis, Presynaptic Dystrophies, and Pathogenic Microglial Activation in 5XFAD Mice	7
Blood Biomarkers Discriminate Cerebral Amyloid Status and Cognitive Diagnosis when Collected with ACD-A Anticoagulant	7
Serine Racemase Expression Differentiates Aging from Alzheimer’s Brain	7
Trace Element Concentration and Cognitive Dysfunction in Elderly Residents in Birjand	7
Comparison of the Mini-Mental State Examination and Computerized Brief Cognitive Screening Test as Cognitive Screening Tools in Patients with Mild Cognitive Impairment	7
Effects of Supplementation with Probiotics in Experimental Models of Alzheimer's Disease: A Systematic Review of Animal Experiments	7
The Immunopathy of Alzheimer’s Disease: Innate or Adaptive?	6
Development and Validation of a Model to Identify Alzheimer’s Disease and Related Syndromes in Administrative Data	6
Effects of the Recurrent and Different Doses of Ketamine Exposure on Anxiety-like Behaviors and Locomotor Activity in Juvenile Rats	6
Familial Early-Onset Alzheimer's Caused by Novel Genetic Variant and APP Duplication: A Cross-Sectional Study	6
Assessment of apolipoprotein E genotype for β-amyloid status prediction	6
Alterations in Peripheral Metabolites as Key Actors in Alzheimer’s Disease	6
Beyond Conventional Therapies: Molecular Dynamics of Alzheimer's Treatment through CLOCK/BMAL1 Interactions	6
Low Intensity Electromagnetic Fields Act via Voltage-Gated Calcium Channel (VGCC) Activation to Cause Very Early Onset Alzheimer’s Disease: 18 Distinct Types of Evidence	6
Correlation of Neuropsychiatric Symptoms in Dementia with Brain Perfusion: A 99mTc-SPECT-HMPAO Study with Brodmann Areas Analysis	6
Assessing the Stability of Clusters of Neuropsychiatric Symptoms in Alzheimer’s Disease and Mild Cognitive Impairment	6
Association Between Cannabis Use and Subjective Cognitive Decline: Findings from the Behavioral Risk Factor Surveillance System (BRFSS)	6
The Impact of Uremic Toxins on Alzheimer's Disease	6
Dietary Components and Nutritional Strategies for Dementia Prevention in the Elderly	6
Development and Psychometric Validation of the 27 Item Zarit Caregiver Interview for Alzheimer’s Disease (ZCI-AD-27)	6
Caffeine Improve Memory and Cognition via Modulating Neural Progenitor Cell Survival and Decreasing Oxidative Stress in Alzheimer's Rat Model	6
Handwriting Markers for the Onset of Alzheimer’s Disease	6
Comparative Efficacy and Acceptability of Cholinesterase Inhibitors and Memantine Based on Dosage in Patients with Vascular Cognitive Impairment: A Network Meta-analysis	6
Age- and Genotype-Dependent Effects of Chronic Nicotine on Presenilin1/2 Double Knockout Mice: From Behavior to Molecular Pathways	6
The Relationship between Alzheimer's Disease and Ferroptosis: A Bibliometric Study Based on Citespace	6
Control of β-Site Amyloid Precursor Protein-Cleaving Enzyme-1 Expression by Protein Kinase C-λ/ι and Nuclear Factor κ-B	5
Application of Diffusion Tensor Imaging Based on Automatic Fiber Quantification in Alzheimer's Disease	5
Machine-Based Learning Shifting to Prediction Model of Deteriorative MCI Due to Alzheimer’s Disease - A Two-Year Follow-Up Investigation	5
Disrupted Balance of Gray Matter Volume and Directed Functional Connectivity in Mild Cognitive Impairment and Alzheimer’s Disease	5

Sixteen Weeks of Aerobic Exercise does not Alter Resting-state Connectivity of the Precuneus in Patients with Alzheimer’s Disease	5
Classification of Patients with Alzheimer’s Disease and Dementia with Lewy Bodies using Resting EEG Selected Features at Sensor and Source Levels: A Proof-of-Concept Study	5
Assessing the Influence of Salvia triloba on Memory Deficit Caused by Sleep Deprivation in the Context of Oxidative Stress	5
GIRK2 Channels in Down Syndrome and Alzheimer’s Disease	5
Systematic Characterization of Heterogeneity Caused by Neuroinflammation in Alzheimer’s Disease Based on Integrative Network Analysis	5
Cogstim: A Shared Decision-making Model to Support Older Adults’ Brain Health	5
RNA Hypomethylation and Unchanged DNA Methylation Levels in the Cortex of ApoE4 Carriers and Alzheimer’s Disease Subjects	5
ceRNA Network Analysis Reveals AP-1 Transcription Factor Components as Potential Biomarkers for Alzheimer’s Disease	5
Comprehensive Analysis of Differential Expression Profiles of Long Noncoding RNAs with Associated Co-expression and Competing Endogenous RNA Networks in the Hippocampus of Patients with Alzheimer's Di	5
Palmitoylated Prolactin-releasing Peptide Reduced Aβ Plaques and Microgliosis in the Cerebellum: APP/PS1 Mice Study	5
Temporal Speech Parameters Detect Mild Cognitive Impairment in Different Languages: Validation and Comparison of the Speech-GAP Test® in English and Hungarian	5
Gastrointestinal Changes and Alzheimer's Disease	5
Development and Optimization of a Target Engagement Model of Brain IDO Inhibition for Alzheimer’s Disease	5
Multiomics Investigation of Hypertension and White Matter Hyperintensity as a Source of Vascular Dementia or a Comorbidity to Alzheimer’s Disease	5