OOIR: Observatory of International Research

Papers

(The TQCC of Mitochondrion is 10. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-04-01 to 2025-04-01.)

Article	Citations
Yeast Dnm1G178R causes altered organelle dynamics and sheds light on the human DRP1G149R disease mechanism	133
Mitochondrial DNA (mtDNA) accelerates oxygen-glucose deprivation-induced injury of proximal tubule epithelia cell via inhibiting NLRC5	127
SIRT6 suppresses colon cancer growth by inducing apoptosis and autophagy through transcriptionally down-regulating Survivin	124
Editorial Board	85
Development of a sensitive double TaqMan Probe-based qPCR Angle-Degree method to detect mutation frequencies	51
Hemispheric analysis of mitochondrial Complex I and II activity in the mouse model of ischemia-reperfusion-induced injury	49
Mitochondrial bioenergetics and cytometric characterization of a synaptosomal preparation from mouse brain cortex	48
The biology of mitochondrial carrier homolog 2	46
Mitochondrial DNA mutations do not impact early human embryonic development	45
Deciphering the role of MitomiRs in cancer: A comprehensive review	44
Molecular docking and simulation studies of phytocompounds derived from Centella asiatica and Andrographis paniculata against hexokinase II as mitocan agents	44
Mitochondrial and metabolic features of salugenesis and the healing cycle	40
β-Hydroxybutyrate preferentially enhances neuron over astrocyte respiration while signaling cellular quiescence	40
Differential role of prolyl hydroxylases on mitochondrial function of HL-1 cells in a model of iron deficiency	37
Mitochondrial dysfunction and inflammasome activation in neurodegenerative diseases: Mechanisms and therapeutic implications	35
Editorial Board	35
The tissue-specific nature of physiological zebrafish mitochondrial bioenergetics	34
Augmented Parkin-dependent mitophagy underlies the hepatoprotective effect of remote ischemic conditioning used prior to hemorrhagic shock	34
Decoding mitochondrial quality control mechanisms: Identifying treatment targets for enhanced cellular health	31
Dysregulation of mitochondrial complexes and dynamics by chronic cigarette smoke exposure Utilizing MitoQC reporter mice	30
Pharmacologic enrichment of exosome yields and mitochondrial cargo	30
Placental mitochondrial DNA mutational load and perinatal outcomes: Findings from a multi-ethnic pregnancy cohort	30
Phenotypes and genotypes of mitochondrial diseases with mtDNA variations in Chinese children: A multi-center study	29
Partial inhibition of mitochondrial-linked pyrimidine synthesis increases tumorigenic potential and lysosome accumulation	29
Cell-free mtDNA level and its biomarker potency for ART outcome are different in follicular fluid of PCOS and non-PCOS women	27

Diagnosis of primary mitochondrial disorders -Emphasis on myopathological aspects	27
Mitochondrial calcium signaling in the brain and its modulation by neurotropic viruses	27
Primary ovarian insufficiency in RMND1 mitochondrial disease	26
Clinical heterogeneity in patients with m.4412G > A MT-TM mutation and different heteroplasmy levels	26
Long read mitochondrial genome sequencing using Cas9-guided adaptor ligation	26
The maternal genetic origin and diversity of the extant populations of the Ladakh region in India	25
Leber’s hereditary optic neuropathy: Current approaches and future perspectives on Mesenchymal stem cell-mediated rescue	25
Mitochondrial DNA haplogroups J and T increase the risk of glioma	25
Mitochondrial functioning in Rheumatoid arthritis modulated by estrogen: Evidence-based insight into the sex-based influence on mitochondria and disease	24
Human clinical mutations in mitochondrially encoded subunits of Complex I can be successfully modeled in E. coli	23
Sequencing errors in Native American mitogenomes: Impact on clade definitions, haplogroup assignation, and beyond	22
Disturbance in communication between mitochondrial redox processes and the AMPK/PGC-1α/SIRT-1 axis influences diverse organ symptoms in lupus-affected mice	22
An integrated multi-omics approach allowed ultra-rapid diagnosis of a deep intronic pathogenic variant in PDHX and precision treatment in a neonate critically ill with lactic acidosis	21
The multifaceted modulation of mitochondrial metabolism in tumorigenesis	21
Corrigendum to “Comparison of whole genome sequencing and targeted sequencing for mitochondrial DNA” [Mitochondrion 58 (2021) 303–310]	20
The role of mtDNA haplogroups on metabolic features in narcolepsy type 1	20
Repeated mild traumatic brain injuries perturb the mitochondrial biogenesis via DNA methylation in the hippocampus of rat	20
Global view of dynamic expression and precise mapping of mitochondrial tRNAs-derived fragments during stressed conditions in S. pombe	19
Megamitochondria plasticity: Function transition from adaption to disease	19
Screening clusters of charged residues in plants’ mitochondrial proteins and biological significance	18
Identification of a novel MT-ND3 variant and restoring mitochondrial function by allotopic expression of MT-ND3 gene	18
Effects of chronic hydrogen peroxide exposure on mitochondrial oxidative stress genes, ROS production and lipid peroxidation in HL60 cells	18
Genetic heterogeneity and respiratory chain enzyme analysis in pediatric Indian patients with mitochondrial disorder: Report of novel variants in POLG1 gene and their functional implication using mole	18
Escherichia coli infection induces ferroptosis in bovine mammary epithelial cells by activating the Wnt/β-catenin pathway-mediated mitophagy	17
Cell-penetrating peptides with nanoparticles hybrid delivery vectors and their uptake pathways	17
Mitochondrial miRNAs (MitomiRs): Their potential roles in breast and other cancers	17
Mitochondrial transfer from mesenchymal stem cells: Mechanisms and functions	17
Molecular basis of sepsis: A New insight into the role of mitochondrial DNA as a damage-associated molecular pattern	17
Application research of novel peptide mitochondrial-targeted antioxidant SS-31 in mitigating mitochondrial dysfunction	16
CMT2A-linked MFN2 mutation, T206I promotes mitochondrial hyperfusion and predisposes cells towards mitophagy	16
The molecular role of Sigmar1 in regulating mitochondrial function through mitochondrial localization in cardiomyocytes	16
Cardiac-specific β-catenin deletion dysregulates energetic metabolism and mitochondrial function in perinatal cardiomyocytes	15
Mitochondrial acyl carrier protein, Acp1, required for iron-sulfur cluster assembly in mitochondria and cytoplasm in Saccharomyces cerevisiae	15
Serum fibroblast growth factor 21 and growth differentiation factor 15: Two sensitive biomarkers in the diagnosis of mitochondrial disorders	15
Mitochondrial respiration is controlled by Allostery, Subunit Composition and Phosphorylation Sites of Cytochrome c Oxidase: A trailblazer’s tale – Bernhard Kadenbach	15
Hsp90 and its mitochondrial homologue TRAP-1 independently regulate hypoxia adaptations in Caenorhabditis elegans	15
Metabolic abnormality in acute stroke-like lesion and its relationship with focal cerebral blood flow in patients with MELAS: Evidence from proton MR spectroscopy and arterial spin labeling	15
Endoplasmic reticulum & mitochondrial calcium homeostasis: The interplay with viruses	14
Neuroprotective compounds alter the expression of genes coding for proteins related to mitochondrial function in activated microglia	14
Altered insulin pathway compromises mitochondrial function and quality control both in in vitro and in vivo model systems	14
Micronutrients/miRs/ATP networking in mitochondria: Clinical intervention with ferroptosis, cuproptosis, and calcium burden	14
Mitophagy pathways and Alzheimer's disease: From pathogenesis to treatment	14
Substitution of leucine by glutamate perturbs VopE localization to mitochondria: Lessons from yeast model system	14
Precise annotation of Drosophila mitochondrial genomes leads to insights into AT-rich regions	14
The Interplay of Mitochondrial Dysfunction in Oral Diseases: Recent Updates in Pathogenesis and Therapeutic Implications	14
Extracellular vesicles as carriers for mitochondria: Biological functions and clinical applications	14
Chelating mitochondrial iron and copper: Recipes, pitfalls and promise	14
The role of mitochondrial DNA variants and dysfunction in the pathogenesis and progression of multiple sclerosis	13
Editorial Board	13
Stressed mitochondria: A target to intrude alzheimer’s disease	13

Whole genome sequencing followed by functional analysis of genomic deletion encompassing ERCC8 and NDUFAF2 genes in a non-consanguineous Indian family reveals dysfunctional mitochondrial bioenergetics	13
Editorial Board	13
Assessment of mitochondrial DNA copy number variation relative to nuclear DNA quantity between different tissues	13
Differential responses of AMD mitochondrial DNA haplogroups to PU-91, a mitochondria-targeting drug	13
The unusual suspect: A novel role for intermediate filament proteins in mitochondrial morphology	13
WITHDRAWN: Advances in mitochondrial medicine and translational research	12
Activation of multifunctional DNA repair APE1/Ref-1 enzyme by the dietary phytochemical Ferulic acid protects human neuroblastoma SH-SY5Y cells against Aβ(25–35)-induced oxidative stress and inflammat	12
Tissue imaging reveals disruption of epithelial mitochondrial networks and loss of mitochondria-associated cytochrome-C in inflamed human and murine colon	12
Prognostic value of circulating mitochondrial DNA in prostate cancer and underlying mechanism	12
Novel blood and tissue-based mitochondrial D-loop mutations detected in an Iranian NAFLD patient cohort	12
Corrigendum to “Prognostic value of circulating mitochondrial DNA in prostate cancer and underlying mechanism” [Mitochondrion 71 (2023) 40-49]	12
The diversity and coexistence of extracellular mitochondria in circulation: A friend or foe of the immune system	12
Comparison of whole genome sequencing and targeted sequencing for mitochondrial DNA	11
What can we do to optimize mitochondrial transplantation therapy for myocardial ischemia–reperfusion injury?	11
Cumulative effects of mutation accumulation on mitochondrial function and fitness	11
Mitochondrial calcium at the synapse	11
The interplay of epilepsy with impaired mitophagy and autophagy linked dementia (MAD): A review of therapeutic approaches	11
Mitochondria determine response to anti-programmed cell death protein-1 (anti-PD-1) immunotherapy: An evidence-based hypothesis	11
Mitochondrial DNA alterations in the domestic dog (Canis lupus familiaris) and their association with development of diseases: A review	11
Mitochondrial bioenergetics of breast cancer	11
Mitochondrial ribosomal protein genes connected with Alzheimer’s and tellurite toxicity	10
Involvement of mitochondria in Alzheimer’s disease pathogenesis and their potential as targets for phytotherapeutics	10
Polysulfide inhibits hypoxia-elicited hypoxia-inducible factor activation in a mitochondria-dependent manner	10
Triplication of HSA21 on alterations in structure and function of mitochondria	10
Scientific investigation of non-coding RNAs in mitochondrial epigenetic and aging disorders: Current nanoengineered approaches for their therapeutic improvement	10
Mitochondrial dysfunction, a weakest link of network of aging, relation to innate intramitochondrial immunity of DNA recognition receptors	10
Mitochondrial Mechanisms in Temozolomide Resistance: Unraveling the Complex Interplay and Therapeutic Strategies in Glioblastoma	10
Differential effects of 808-nm light on electron transport chain enzymes in isolated mitochondria: Implications for photobiomodulation initiation	10
Delivery of mitoceuticals or respiratory competent mitochondria to sites of neurotrauma	10
Blood mitochondrial DNA copy number: What are we counting?	10