Current Cancer Drug Targets

Papers
(The TQCC of Current Cancer Drug Targets is 4. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-11-01 to 2025-11-01.)
ArticleCitations
The Expression of Glutaminases and their Association with Clinicopathological Parameters in the Head and Neck Cancers86
Micro-fragmented Fat Inhibits the Progression of Human Mesothelioma Xenografts in Mice45
FHOD3 Promotes the Progression of Lung Cancer by Regulating the Caspase-3-Mediated Signaling Pathway41
A Review on Patient-derived 3D Micro Cancer Approach for Drug Screen in Personalized Cancer Medicine37
Progress in Metabolic Studies of Gastric Cancer and Therapeutic Implications34
Etiology-based Molecular Characterization of Hepatocellular Carcinoma Reveals SQLE's Contribution to Immunosuppressive Microenvironment27
A Pilot Study of Anlotinib as a Combination Treatment in Advanced Nasopharyngeal Carcinoma26
Knockdown of PRKD2 Enhances Chemotherapy Sensitivity in Cervical Cancer via the TP53/CDKN1A Pathway26
TBOPP, a DOCK1 Inhibitor, Potentiates Cisplatin Efficacy in Breast Cancer by Regulating Twist-mediated EMT26
Expression, Prognostic Value, and Immune Infiltration of MTHFD Family in Bladder Cancer25
Silencing HEATR1 Rescues Cisplatin Resistance of Non-small Cell Lung Cancer by Inducing Ferroptosis via the p53/SAT1/ALOX15 Axis23
LMNB1/CDKN1A Signaling Regulates the Cell Cycle and Promotes Hepatocellular Carcinoma Progression18
Unveiling Novel Therapeutic Drug Targets and Prognostic Markers of Triple Negative Breast Cancer16
Efficacy and Safety of Immunotherapy Combined with Anlotinib as First-Line Treatment in Older NSCLC Patients with PD-L1 Expression<50%16
Immune Checkpoint Inhibitors for Advanced Biliary Tract Cancer14
Development of Chromatin Regulator-related Molecular Subtypes and a Signature to Predict Prognosis and Immunotherapeutic Response in Head and Neck Squamous Cell Carcinoma14
Spinal KCC2 Mediates the Modulation Effect of HDAC2 on Bone Cancer Pain in Rats14
Combined RNAi of CTTN and FGF2 Modulates Cell Migration, Invasion and G1/S Transition of Hepatocellular Carcinoma through Ras/ERK Signaling Pathway14
Bioinformatics and Experimental Study Revealed LINC00982/ miR-183-5p/ABCA8 Axis Suppresses LUAD Progression14
The Therapeutic Potential of Urolithin A for Cancer Treatment and Prevention14
Identification of ATM Mutation as a Potential Prognostic Biomarker for Immune Checkpoint Inhibitors Therapy14
Inorganic Phosphate (Pi) in the Breast Cancer Microenvironment: Production, Transport and Signal Transduction as Potential Targets for Anticancer Strategies13
PLCG2, A Regulator of Lung Adenocarcinoma Proliferation and Migration Associated with Immune Infiltration13
Review Deciphering the Potential of Nanotherapeutics in Lung Cancer Management13
High Expression of PKMYT1 Predicts Poor Prognosis and Aggravates the Progression of Osteosarcoma via the NF-κB Pathway in MG63 Cells13
MMP7, Regulated by c-Jun, is Involved in Oral Squamous Cell Carcinoma and Associated with Cancer-Related Fibroblasts Infiltration13
LINC00461 Knockdown Enhances the Effect of Ixazomib in Multiple Myeloma Cells13
Role of Natural Nuclear Factor Erythroid-2-related Factor 2 (Nrf2) Activators in Oral and Head and Neck Cancer Treatment13
Downregulation of CCKBR Expression Inhibits the Proliferation of Gastric Cancer Cells, Revealing a Potential Target for Immunotoxin Therapy12
A Molecular Link Between Diabetes and Breast Cancer: Therapeutic Potential of Repurposing Incretin-based Therapies for Breast Cancer12
Low Expression of SCN4B Predicts Poor Prognosis in Non-small Cell Lung Cancer12
WITHDRAWN: Use of Tumor-Infiltrating Lymphocyte (TIL) Cell Therapy for Spindle Cell Carcinoma of the Breast: A Case Report12
Targeting the HIF-1α/Cav-1 Pathway with a Chicory Extract/Daidzein Combination Plays a Potential Role in Retarding Hepatocellular Carcinoma11
Epigallocatechin-3-gallate Induced HepG2 Cells Apoptosis through ROSmediated AKT /JNK and p53 Signaling Pathway11
EGF/EGFR Promotes Salivary Adenoid Cystic Carcinoma Cell Malignant Neural Invasion via Activation of PI3K/AKT and MEK/ERK Signaling11
Identification of AHSA1 as a Potential Therapeutic Target for Breast Cancer: Bioinformatics Analysis and in vitro Studies10
Nanodiamond Mediated Molecular Targeting in Pancreatic Ductal Adenocarcinoma: Disrupting the Tumor-stromal Cross-talk, Next Hope on the Horizon?10
An Updated Review on Molecular Biomarkers in Diagnosis and Therapy of Colorectal Cancer10
Transcription Factor MAZ Potentiates the Upregulated NEIL3-mediated Aerobic Glycolysis, thereby Promoting Angiogenesis in Hepatocellular Carcinoma10
Real-world Study on the Effect of PARPi as Maintenance Therapy on Platinum Sensitivity after First- and Second-line Chemotherapy in Patients with Recurrent High-grade Serous Epithelial Ovarian Cancer9
Angiotensin-converting Enzyme Inhibitors and Angiotensin Receptor Blockers as Potential Therapeutic Options for Pancreatic Cancer9
Utilization of DNA Replication factor MCM2 by Cancer9
Anti-breast Cancer Potential of Prosopis cineraria L. Phytocompounds: A Network Pharmacology and in vitro Analysisbased Approach9
Comprehensive Pan-cancer Analysis of CMPK2 as Biomarker and Prognostic Indicator for Immunotherapy9
Withaferin A Inhibits Liver Cancer Tumorigenesis by Suppressing Aerobic Glycolysis through the p53/IDH1/HIF-1α Signaling Axis9
Preventive and Therapeutic effects of Metformin in Cancer: A Meta-Analysis of RCT and Cohort Studies9
Elucidating the Potential of E-cadherin Re-expression along with Trichostatin A and Zebularine in Enhancing Tumour Necrosis Factor-Related Apoptosis-Inducing Ligand (TRAIL)-Induced Apoptosis in Human 9
Solid CaCO3 Formation in Glioblastoma Multiforme and its Treatment with Ultra-Nanoparticulated NPt-Bionanocatalysts9
Protein Tyrosine Phosphatase 1B (PTP1B): Insights into its New Implications in Tumorigenesis9
WITHDRAWN: Hidrosmin Attenuates Inflammatory Response Induced by IL1β by Suppressing the Activation of NF-κB Involving Nrf2/HO1Pathway in Human Osteoarthritis Chondrocytes9
Stabilizing Scaffold for Short Peptides Based on Knottins8
Twenty-four-month Progression-free Survival in HER2-amplified Advanced Gastric Cancer with Brain Metastases after Trastuzumab Deruxtecan Treatment: A Case Report and Literature Review8
Screening miRNAs to Hinder the Tumorigenesis of Renal Clear Cell Carcinoma Associated with KDR Expression8
CEA-regulated Oncolytic Virus Anticancer Therapy: A Promising Strategy for Rare Solid Tumors8
Curcumin Inhibits Vasculogenic Mimicry via Regulating ETS-1 in Renal Cell Carcinoma8
Cancer Vaccine in Cold Tumors: Clinical Landscape, Challenges, and Opportunities8
Gender Matters. Sex-related Differences in Immunotherapy Outcome in Patients with Non-small Cell Lung Cancer8
A Saffron-based Polyherbal Formulation DuK Prevents Hepatocellular Carcinoma in Male Wistar Rats8
FA-HA-Amygdalin@Fe2O3 and/or γ-Rays Affecting SIRT1 Regulation of YAP/TAZ-p53 Signaling and Modulates Tumorigenicity of MDA-MB231 or MCF-7 Cancer Cells8
Long Non-Coding RNA HCP5 Affects Ferroptosis in Lung Adenocarcinoma through miR-17-5p/HOXA7 Axis8
Promotion of Cervical Cancer Cell Proliferation by miR-130b Expression Level Changes and Inhibition of its Apoptosis by Targeting CDKN1A Gene8
HIF-1α/Malat1/miR-141 Axis Activates Autophagy to Increase Proliferation, Migration, and Invasion in Triple-negative Breast Cancer7
Efficacy and Safety of Phosphatidylinositol 3-kinase Inhibitors for Patients with Breast Cancer: A Systematic Review and Meta-analysis of Randomized Controlled Trials7
Advances and Future Prospects of Lipid-Based Nanocarriers in Targeted Cancer Therapy: A Comprehensive Review7
Autophagy in Cancer Cell Transformation: A Potential Novel Therapeutic Strategy7
CDK8 as a therapeutic target for overall survival prediction in cervical squamous cell carcinoma (CESC)7
Precision Medicine in Colorectal Cancer: Targeted Therapies and Biomarker Insights7
Neuronatin Promotes the Progression of Non-small Cell Lung Cancer by Activating the NF-κB Signaling7
Recent Advancements in Drug Targeting for Ferroptosis as an Antitumor Therapy: Development of Novel therapeutics7
Elucidation of the Role of the Epigenetic Regulatory Mechanisms of PI3K/Akt/mTOR Signaling Pathway in Human Malignancies7
COL10A1 as a Prognostic Biomarker in Association with Immune Infiltration in Prostate Cancer7
RON Receptor Tyrosine Kinase in Tumorigenic Stemness as a Therapeutic Target of Antibody-drug Conjugates for Eradication of Triple-negative Breast Cancer Stem Cells7
Progressive Dynamics of Cancer Stem Cells in Oral Squamous Cell Carcinoma7
Spleen Glucose Metabolism on [18F]-FDG PET/CT for Cancer Drug Discovery and Development cannot be Overlooked7
TROP2 Down-regulated DSG2 to Promote Gastric Cancer Cell Invasion and Migration by EGFR/AKT and DSG2/PG/β-Catenin Pathways7
Pathological Implications of Mucin Signaling in Metastasis7
Combinatorial Application of Papain and CD66B for Isolating Glioma- Associated Neutrophils7
Silencing TRIM29 Sensitizes Non-small Cell Lung Cancer Cells to Anlotinib by Promoting Apoptosis via Binding RAD507
Targeting Glutamine Metabolic Reprogramming in Pancreatic Cancer: Current Insights and Future Directions7
Combination Therapy with Androgen Receptor Pathway Inhibitors for Prostate Cancer6
Current Challenges in Targeting Tumor Desmoplasia to Improve the Efficacy of Immunotherapy6
Repurposing of Antidiarrheal Loperamide for Treating Melanoma by Inducing Cell Apoptosis and Cell Metastasis Suppression In vitro and In vivo6
mirna-383-5p Functions as an Anti-oncogene in Glioma through the Akt/mTOR Signaling Pathway by Targeting VEGFA6
Tumor-Activated Neutrophils Promote Lung Cancer Progression through the IL-8/PD-L1 Pathway6
Exploring the Role of Long Non-Coding RNAs in Mediating Cisplatin Resistance in Colorectal Cancer6
Comparison of Surgical and Colonoscopy Tissue to Establish Colorectal Patient-derived Organoids6
Chimeric Antigen Receptor (CAR) T-cell Therapy: A New Genetically Engineered Method of Immunotherapy for Cancer6
L-lysine Increases the Anticancer Effect of Doxorubicin in Breast Cancer by Inducing ROS-dependent Autophagy6
Assessing Long Non-coding RNAs in Tobacco-associated Oral Cancer6
Unveiling the Therapeutic Potential of Compounds Carrying Mono- and Bis-Thiazole Nuclei with Distinct Heterocyclic Analogues for Addressing Cancer Challenges6
WEE Family Kinase Inhibitors Combined with Sorafenib Can Selectively Inhibit HCC Cell Proliferation6
Coriandrum sativum and Aloysia triphylla can Protect the Development of Cancer: An in Vivo Study using Mouse Painting Assay6
Controversial Role of Opioids: From Pain Control to Cancer Recurrence in Breast Cancer6
Silencing of FANCI Promotes DNA Damage and Sensitizes Ovarian Cancer Cells to Carboplatin6
A Novel Oncogenic Role of Disulfidptosis-related Gene SLC7A11 in Anti-tumor Immunotherapy Response to Human Cancers6
The Imidazacridine Derivative LPSF/AC-05 Induces Apoptosis, Cell Cycle Arrest, and Topoisomerase II Inhibition in Breast Cancer, Leukemia, and Lymphoma6
Is the Use of SGLT-2 Associated with an Increased Risk of Cancer?6
Exosome-mediated Induction of Apoptosis in Cisplatin-treated GastricCancer Cells as a Strategy to Mitigate Side Effects6
Cuproptosis Related Gene DLD Associated with Poor Prognosis and Malignant Biological Characteristics in Lung Adenocarcinoma5
Nanotechnological Advancements for the Theranostic Intervention in Anaplastic Thyroid Cancer: Current Perspectives and Future Direction5
Dietary Flavonoids with Catechol Moiety Inhibit Anticancer Action of Bortezomib: What about the other Boronic Acid-based Drugs?5
Antibody-drug Conjugate Targets, Drugs, and Linkers5
Research Progress of Neural Invasion in Pancreatic Cancer5
Advances in Radiation Therapy Enhancement and Radio-Protection By Nano-Curcumins: A Systematic Review5
RAD50 Deficient in a Breast Cancer Model Predicts Sensitivity to PARP Inhibitors5
Angiogenesis and Pancreatic Cancer: Novel Approaches to Overcome Treatment Resistance5
Targeting the Tumor Epigenetic Regulator SETDB1 for Tumor Therapy5
IR-780 Dye-based Targeting of Cancer-associated Fibroblasts Improves Cancer Immunotherapy by Increasing Intra-tumoral T Lymphocytes Infiltration5
ZIP14 Affects the Proliferation, Apoptosis, and Migration of Cervical Cancer Cells by Regulating the P38 MAPK Pathway5
Resistance of Lenvatinib in Hepatocellular Carcinoma5
The Effects of Mesenchymal Stem Cells Loaded with Oncolytic Coxsackievirus A21 on Mouse Models of Colorectal Cancer5
UCA1 Inhibits NKG2D-mediated Cytotoxicity of NK Cells to Breast Cancer5
Research Advances of Clinical Application of Oncolytic Viruses in Treatment of Gynecologic Cancers5
YM155 Restores the Effect of Imatinib in Imatinib-Resistant Chronic Myeloid Leukemia Cell Lines5
Forkhead Box Protein M1 (FOXM1): Prospective Prognostic Biomarker and Therapeutic Targets in Oral Cancer5
ADH1B Gene Promotes Gastric Cancer Tumorigenesis and its Cisplatin Resistance through the EMT Pathway5
Preface4
Disulfiram-Copper Potentiates Anticancer Efficacy of Standard Chemotherapy Drugs in Bladder Cancer Animal Model through ROS-Autophagy-Ferroptosis Signalling Cascade4
Sildenafil Inhibits the Growth and Epithelial-to-mesenchymal Transition of Cervical Cancer via the TGF-β1/Smad2/3 Pathway4
Efficacy and Safety of Nimotuzumab in Combination with Radiotherapy or Chemoradiotherapy for Local Advanced Head and Neck Cancer: A Systematic Review and Meta-analysis4
Polyphyllin VII is a Potential Drug Targeting CD44 Positive Colon Cancer Cells4
Up-regulation of Core 1 Beta 1, 3-Galactosyltransferase Suppresses Osteosarcoma Growth with Induction of IFN-γ Secretion and Proliferation of CD8+ T Cells4
GPX4 Inhibition Enhances the Antitumor Effect of PARP Inhibitor on Homologous Recombination Proficient Ovarian Cancer Cells4
GAPVD1 Promotes the Proliferation of Triple-negative Breast Cancer Cells by Regulating the ERK/MAPK Signaling Pathway4
Smart Nanobiomaterials for Gene Delivery in Localized Cancer Therapy: An Overview from Emerging Materials and Devices to Clinical Applications4
Εmerging Biomarkers in the Diagnosis and Treatment of Testicular Tumors4
Preface4
AHNAK2 Promotes the Progression of Differentiated Thyroid Cancer through PI3K/AKT Signaling Pathway4
Unravelling the Mechanism of Methylophiopogonanone A Against Esophageal Squamous Cell Carcinoma Based on Network Pharmacology and Molecular Docking4
VX-765 has a Protective Effect on Mice with Ovarian Injury Caused by Chemotherapy4
Durable Disease-free Survival in a Patient with Metastatic Triple-negative Breast Cancer Treated with Olaparib Monotherapy4
The Association between NADPH Oxidase 2 (NOX2) and Drug Resistance in Cancer4
Metastatic Breast Cancer, Organotropism and Therapeutics: A Review4
Comprehensive Pan-cancer Analysis and Experimental Verification of EGLN Family: Potential Biomarkers in Cervical Cancer4
Insights into the Emerging Therapeutic Targets of Triple-negative Breast Cancer4
Mitochondrial Calcium Uniporter (MCU) that Modulates Mitochondrial Calcium Uptake and Facilitates Endometrial Cancer Progression through Interaction with VDAC14
Combined Immunotherapy and Targeted Therapies for Cancer Treatment: Recent Advances and Future Perspectives4
Present and Future Prospects of the Anti-cancer Activities of Saikosaponins4
The Influence of KIR Gene Polymorphisms and KIR-ligand Binding on Outcomes in Hematologic Malignancies following Haploidentical Stem Cell Transplantation: A Comprehensive Review4
The Role of Local Angiotensin II/Angiotensin Type 1-receptor Mechanisms in Adipose Tissue Dysfunction to Promote Pancreatic Cancer4
Dihydrotanshinone I Inhibits Pancreatic Cancer Progression via Hedgehog/ Gli Signal Pathway4
Study on Cellular Localization of Bin Toxin and its Apoptosis-inducing Effect on Human Nasopharyngeal Carcinoma Cells4
Modifications of Ribonucleases in Order to Enhance Cytotoxicity in Anticancer Therapy4
The Prognostic Value and Clinical Significance of lncRNA SNHG5 Expression in Patients with Multiple Malignancies: A Bioinformatic and Meta-analysis4
Recent Progress in the Application of Exosome Analysis in Ovarian Cancer Management4
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