Current Cancer Drug Targets

Papers
(The TQCC of Current Cancer Drug Targets is 5. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2022-05-01 to 2026-05-01.)
ArticleCitations
Immune Checkpoint Inhibitors for Advanced Biliary Tract Cancer96
Development of Chromatin Regulator-related Molecular Subtypes and a Signature to Predict Prognosis and Immunotherapeutic Response in Head and Neck Squamous Cell Carcinoma43
Spinal KCC2 Mediates the Modulation Effect of HDAC2 on Bone Cancer Pain in Rats38
Knockdown of PRKD2 Enhances Chemotherapy Sensitivity in Cervical Cancer via the TP53/CDKN1A Pathway37
Artesunate overcomes lenvatinib resistance by inhibiting the STAT3/SLC25A27 pathway and promoting ferroptosis in hepatocellular carcinoma33
The Therapeutic Potential of Urolithin A for Cancer Treatment and Prevention31
MiR-124-3p Suppresses Glioma Cells Progression by Targeting STAT3/NAMPT and Inhibiting AKT/ERK Signaling30
Identification of ATM Mutation as a Potential Prognostic Biomarker for Immune Checkpoint Inhibitors Therapy29
LMNB1/CDKN1A Signaling Regulates the Cell Cycle and Promotes Hepatocellular Carcinoma Progression29
Silencing HEATR1 Rescues Cisplatin Resistance of Non-small Cell Lung Cancer by Inducing Ferroptosis via the p53/SAT1/ALOX15 Axis27
Bioinformatics and Experimental Study Revealed LINC00982/ miR-183-5p/ABCA8 Axis Suppresses LUAD Progression20
Efficacy and Safety of Immunotherapy Combined with Anlotinib as First-Line Treatment in Older NSCLC Patients with PD-L1 Expression<50%19
Expression, Prognostic Value, and Immune Infiltration of MTHFD Family in Bladder Cancer18
FHOD3 Promotes the Progression of Lung Cancer by Regulating the Caspase-3-Mediated Signaling Pathway18
TBOPP, a DOCK1 Inhibitor, Potentiates Cisplatin Efficacy in Breast Cancer by Regulating Twist-mediated EMT17
Etiology-based Molecular Characterization of Hepatocellular Carcinoma Reveals SQLE's Contribution to Immunosuppressive Microenvironment17
DDX18 as a Prognostic Biomarker Associated with Pan-Cancer Immune Infiltration and Drug Sensitivity17
A Review on Patient-derived 3D Micro Cancer Approach for Drug Screen in Personalized Cancer Medicine17
Progress in Metabolic Studies of Gastric Cancer and Therapeutic Implications16
A Pilot Study of Anlotinib as a Combination Treatment in Advanced Nasopharyngeal Carcinoma16
Combined RNAi of CTTN and FGF2 Modulates Cell Migration, Invasion and G1/S Transition of Hepatocellular Carcinoma through Ras/ERK Signaling Pathway16
Micro-fragmented Fat Inhibits the Progression of Human Mesothelioma Xenografts in Mice16
High Expression of PKMYT1 Predicts Poor Prognosis and Aggravates the Progression of Osteosarcoma via the NF-κB Pathway in MG63 Cells15
Role of Natural Nuclear Factor Erythroid-2-related Factor 2 (Nrf2) Activators in Oral and Head and Neck Cancer Treatment15
LINC00461 Knockdown Enhances the Effect of Ixazomib in Multiple Myeloma Cells14
MMP7, Regulated by c-Jun, is Involved in Oral Squamous Cell Carcinoma and Associated with Cancer-Related Fibroblasts Infiltration13
Inorganic Phosphate (Pi) in the Breast Cancer Microenvironment: Production, Transport and Signal Transduction as Potential Targets for Anticancer Strategies13
Review Deciphering the Potential of Nanotherapeutics in Lung Cancer Management13
PLCG2, A Regulator of Lung Adenocarcinoma Proliferation and Migration Associated with Immune Infiltration13
Low Expression of SCN4B Predicts Poor Prognosis in Non-small Cell Lung Cancer13
WITHDRAWN: Use of Tumor-Infiltrating Lymphocyte (TIL) Cell Therapy for Spindle Cell Carcinoma of the Breast: A Case Report13
EGF/EGFR Promotes Salivary Adenoid Cystic Carcinoma Cell Malignant Neural Invasion via Activation of PI3K/AKT and MEK/ERK Signaling13
Epigallocatechin-3-gallate Induced HepG2 Cells Apoptosis through ROSmediated AKT /JNK and p53 Signaling Pathway12
Aurora Kinases as Potential Therapeutic Targets for Tumors with pRB and/or MYCN Dysregulation12
Nanodiamond Mediated Molecular Targeting in Pancreatic Ductal Adenocarcinoma: Disrupting the Tumor-stromal Cross-talk, Next Hope on the Horizon?12
Comparative Analysis of Homologous Recombination Repair Status Across Gynecologic and Breast Cancers in Chinese Populations11
Angiotensin-converting Enzyme Inhibitors and Angiotensin Receptor Blockers as Potential Therapeutic Options for Pancreatic Cancer11
Solid CaCO3 Formation in Glioblastoma Multiforme and its Treatment with Ultra-Nanoparticulated NPt-Bionanocatalysts11
Comprehensive Pan-cancer Analysis of CMPK2 as Biomarker and Prognostic Indicator for Immunotherapy11
A Novel Oncogene and Therapeutic Target, Germ Cell-Specific Gene 2 (GSG2), Plays Complex Roles in Promoting Malignant Progression of Glioma11
Withaferin A Inhibits Liver Cancer Tumorigenesis by Suppressing Aerobic Glycolysis through the p53/IDH1/HIF-1α Signaling Axis11
WITHDRAWN: Hidrosmin Attenuates Inflammatory Response Induced by IL1β by Suppressing the Activation of NF-κB Involving Nrf2/HO1Pathway in Human Osteoarthritis Chondrocytes10
An Updated Review on Molecular Biomarkers in Diagnosis and Therapy of Colorectal Cancer10
Real-world Study on the Effect of PARPi as Maintenance Therapy on Platinum Sensitivity after First- and Second-line Chemotherapy in Patients with Recurrent High-grade Serous Epithelial Ovarian Cancer10
Elucidating the Potential of E-cadherin Re-expression along with Trichostatin A and Zebularine in Enhancing Tumour Necrosis Factor-Related Apoptosis-Inducing Ligand (TRAIL)-Induced Apoptosis in Human 10
Anti-breast Cancer Potential of Prosopis cineraria L. Phytocompounds: A Network Pharmacology and in vitro Analysisbased Approach10
Transcription Factor MAZ Potentiates the Upregulated NEIL3-mediated Aerobic Glycolysis, thereby Promoting Angiogenesis in Hepatocellular Carcinoma10
Preventive and Therapeutic effects of Metformin in Cancer: A Meta-Analysis of RCT and Cohort Studies10
Utilization of DNA Replication factor MCM2 by Cancer10
Twenty-four-month Progression-free Survival in HER2-amplified Advanced Gastric Cancer with Brain Metastases after Trastuzumab Deruxtecan Treatment: A Case Report and Literature Review10
Long Non-Coding RNA HCP5 Affects Ferroptosis in Lung Adenocarcinoma through miR-17-5p/HOXA7 Axis9
Stabilizing Scaffold for Short Peptides Based on Knottins9
Patterns and Predictors of Carboplatin-Induced Myelotoxicity in Breast Cancer Patients: A Six-Year Retrospective Analysis9
Recent Advancements in Drug Targeting for Ferroptosis as an Antitumor Therapy: Development of Novel therapeutics9
Neuronatin Promotes the Progression of Non-small Cell Lung Cancer by Activating the NF-κB Signaling9
Curcumin Inhibits Vasculogenic Mimicry via Regulating ETS-1 in Renal Cell Carcinoma9
A Saffron-based Polyherbal Formulation DuK Prevents Hepatocellular Carcinoma in Male Wistar Rats9
Targeting Glutamine Metabolic Reprogramming in Pancreatic Cancer: Current Insights and Future Directions9
Cancer Vaccine in Cold Tumors: Clinical Landscape, Challenges, and Opportunities9
Precision Medicine in Colorectal Cancer: Targeted Therapies and Biomarker Insights9
Inhibition of CD24 Expression Enhances the Anti-Melanoma Effect of Endostatin by Ameliorating Anti-Tumor Immune Responses in Melanoma-Bearing Mice9
Screening miRNAs to Hinder the Tumorigenesis of Renal Clear Cell Carcinoma Associated with KDR Expression9
FA-HA-Amygdalin@Fe2O3 and/or γ-Rays Affecting SIRT1 Regulation of YAP/TAZ-p53 Signaling and Modulates Tumorigenicity of MDA-MB231 or MCF-7 Cancer Cells9
Progressive Dynamics of Cancer Stem Cells in Oral Squamous Cell Carcinoma8
CDK8 as a therapeutic target for overall survival prediction in cervical squamous cell carcinoma (CESC)8
Autophagy in Cancer Cell Transformation: A Potential Novel Therapeutic Strategy8
The Regulation of Ferroptosis by circRNAs in Various Cancers8
Gender Matters. Sex-related Differences in Immunotherapy Outcome in Patients with Non-small Cell Lung Cancer8
Silencing TRIM29 Sensitizes Non-small Cell Lung Cancer Cells to Anlotinib by Promoting Apoptosis via Binding RAD508
Pathological Implications of Mucin Signaling in Metastasis8
TROP2 Down-regulated DSG2 to Promote Gastric Cancer Cell Invasion and Migration by EGFR/AKT and DSG2/PG/β-Catenin Pathways8
RON Receptor Tyrosine Kinase in Tumorigenic Stemness as a Therapeutic Target of Antibody-drug Conjugates for Eradication of Triple-negative Breast Cancer Stem Cells8
Advances and Future Prospects of Lipid-Based Nanocarriers in Targeted Cancer Therapy: A Comprehensive Review8
Efficacy and Safety of Phosphatidylinositol 3-kinase Inhibitors for Patients with Breast Cancer: A Systematic Review and Meta-analysis of Randomized Controlled Trials8
Combinatorial Application of Papain and CD66B for Isolating Glioma- Associated Neutrophils7
The Imidazacridine Derivative LPSF/AC-05 Induces Apoptosis, Cell Cycle Arrest, and Topoisomerase II Inhibition in Breast Cancer, Leukemia, and Lymphoma7
Exploring the Role of Long Non-Coding RNAs in Mediating Cisplatin Resistance in Colorectal Cancer7
Elucidation of the Role of the Epigenetic Regulatory Mechanisms of PI3K/Akt/mTOR Signaling Pathway in Human Malignancies7
In Silico Multi-omics Analyses of Kinesin Family Member 15 in Pan-Cancer and Validation in Tissue Microarray7
mirna-383-5p Functions as an Anti-oncogene in Glioma through the Akt/mTOR Signaling Pathway by Targeting VEGFA7
Chimeric Antigen Receptor (CAR) T-cell Therapy: A New Genetically Engineered Method of Immunotherapy for Cancer7
HIF-1α/Malat1/miR-141 Axis Activates Autophagy to Increase Proliferation, Migration, and Invasion in Triple-negative Breast Cancer7
WEE Family Kinase Inhibitors Combined with Sorafenib Can Selectively Inhibit HCC Cell Proliferation7
Coriandrum sativum and Aloysia triphylla can Protect the Development of Cancer: An in Vivo Study using Mouse Painting Assay7
Silencing of FANCI Promotes DNA Damage and Sensitizes Ovarian Cancer Cells to Carboplatin7
A Novel Platinum-Resistance-related Gene Signature in Ovarian Cancer: Identification and Patient-derived Organoids Verification6
Combination Therapy with Androgen Receptor Pathway Inhibitors for Prostate Cancer6
Unveiling the Therapeutic Potential of Compounds Carrying Mono- and Bis-Thiazole Nuclei with Distinct Heterocyclic Analogues for Addressing Cancer Challenges6
Exploration of the Synergistic Effect of Chitosan Oligosaccharide and Dacarbazine (DTIC) in the Treatment of Melanoma6
Is the Use of SGLT-2 Associated with an Increased Risk of Cancer?6
Exosome-mediated Induction of Apoptosis in Cisplatin-treated GastricCancer Cells as a Strategy to Mitigate Side Effects6
Comparison of Surgical and Colonoscopy Tissue to Establish Colorectal Patient-derived Organoids6
YM155 Restores the Effect of Imatinib in Imatinib-Resistant Chronic Myeloid Leukemia Cell Lines6
L-lysine Increases the Anticancer Effect of Doxorubicin in Breast Cancer by Inducing ROS-dependent Autophagy6
COL10A1 as a Prognostic Biomarker in Association with Immune Infiltration in Prostate Cancer6
Assessing Long Non-coding RNAs in Tobacco-associated Oral Cancer6
Repurposing of Antidiarrheal Loperamide for Treating Melanoma by Inducing Cell Apoptosis and Cell Metastasis Suppression In vitro and In vivo6
Integrative Deep Learning from H&E Images Reveals Prognostically Distinct Pathology-Based Subtypes in Bladder Cancer6
Exploring the Impact of Chitosan-Based Nanoparticles in Cancer Targeted Drug Delivery: A Bibliometric Review6
A Novel Oncogenic Role of Disulfidptosis-related Gene SLC7A11 in Anti-tumor Immunotherapy Response to Human Cancers6
Resistance of Lenvatinib in Hepatocellular Carcinoma5
Research Advances of Clinical Application of Oncolytic Viruses in Treatment of Gynecologic Cancers5
The Effects of Mesenchymal Stem Cells Loaded with Oncolytic Coxsackievirus A21 on Mouse Models of Colorectal Cancer5
Cuproptosis Related Gene DLD Associated with Poor Prognosis and Malignant Biological Characteristics in Lung Adenocarcinoma5
Targeting Lactate Metabolism in Cancer Therapy: The Mechanism of Lactylation Modification and Prospects of Therapeutic Strategies5
Efficacy and Safety of Nimotuzumab in Combination with Radiotherapy or Chemoradiotherapy for Local Advanced Head and Neck Cancer: A Systematic Review and Meta-analysis5
Forkhead Box Protein M1 (FOXM1): Prospective Prognostic Biomarker and Therapeutic Targets in Oral Cancer5
Machine Vision Approaches for Cervical Cancer Screening Using Pap-Smear Images: A Systematic Review5
Molecular Targets and Nano-Technological Approaches in the Treatment of Hepatic Carcinoma5
ADH1B Gene Promotes Gastric Cancer Tumorigenesis and its Cisplatin Resistance through the EMT Pathway5
Phytochemicals as Promising Therapeutics in Cancer Prevention and Treatment: Mechanisms and Applications5
RAD50 Deficient in a Breast Cancer Model Predicts Sensitivity to PARP Inhibitors5
Controversial Role of Opioids: From Pain Control to Cancer Recurrence in Breast Cancer5
ZIP14 Affects the Proliferation, Apoptosis, and Migration of Cervical Cancer Cells by Regulating the P38 MAPK Pathway5
VX-765 has a Protective Effect on Mice with Ovarian Injury Caused by Chemotherapy5
The Clinical Role of Hypoxia Inducible Factor (HIF) Inhibition in Renal Cancer: A Focus on Belzutifan5
Antibody-drug Conjugate Targets, Drugs, and Linkers5
Angiogenesis and Pancreatic Cancer: Novel Approaches to Overcome Treatment Resistance5
Nanotechnological Advancements for the Theranostic Intervention in Anaplastic Thyroid Cancer: Current Perspectives and Future Direction5
Advances in Radiation Therapy Enhancement and Radio-Protection By Nano-Curcumins: A Systematic Review5
Tumor-Activated Neutrophils Promote Lung Cancer Progression through the IL-8/PD-L1 Pathway5
Dietary Flavonoids with Catechol Moiety Inhibit Anticancer Action of Bortezomib: What about the other Boronic Acid-based Drugs?5
UCA1 Inhibits NKG2D-mediated Cytotoxicity of NK Cells to Breast Cancer5
Preface5
Targeting the Tumor Epigenetic Regulator SETDB1 for Tumor Therapy5
Research Progress of Neural Invasion in Pancreatic Cancer5
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