Current Topics in Medicinal Chemistry

Article	Citations
Discovery of MMP1 Inhibitors from Dandelion using Molecular Simulation and Bioactivity Test	67
Recent Developments in the Therapeutics for Endocrine Diseases	67
Fighting Antimicrobial Resistance with Natural Products - Current Developments and Future Prospects	66
Valeriana jatamansi: Bioactive Compounds and their Medicinal Uses	60
Qi Yin San Liang San Decoction Relieves Gefitinib-Induced Diarrhea via the Modulation of Chemokines and Innate Immune Responses	49
Application of Virtual Sample Generation and Screening in Process Parameter Optimization of Botanical Medicinal Materials	48
The Role of Herbal Medicine in Modulating Bone Homeostasis	47
Tackling Nontuberculous Mycobacteria by Repurposable Drugs and Potential Leads from Natural Products	43
Green Synthesis of Biorelevant Scaffolds through Organocatalytic/ Enzymatic Dynamic Kinetic Resolution	41
Eco-friendly Approaches to Chromene Derivatives: A Comprehensive Review of Green Synthesis Strategies	40
Ethyl Acetate Extract from Wenxia Formula (WFEA) Attenuates Immunosuppression in Lung Cancer by Inhibiting Treg Differentiation via Blockade of TGF-Β/Smad Signaling	40
Formononetin-Celecoxib Conjugate as Matrix Metalloproteinase 9 Inhibitor for Osteoarthritis Therapy	39
Optimization, Preparation, and Cytotoxic Potential of Pyrus communisExtract Loaded Ethosomes on Skin Cancer Cell Lines	38
Computer-aided Drug Discovery of Epigenetic Modulators in Dual-target Therapy of Multifactorial Diseases	37
From Nature to Drug: Overview and CADD Approach of Anacardic Acid to Propose their Biological Potential	35
The Gut Microbiota-Brain Axis: Potential Mechanism of Drug Addiction	34
Next-generation Bruton’s Tyrosine Kinase (BTK) Inhibitors Potentially Targeting BTK C481S Mutation- Recent Developments and Perspectives	34
Wnt Signaling in Tumorigenesis: From Molecular Mechanisms to Precision Therapeutic Targets	33
Modern Approaches to Diabetes: The Role of Phytochemicals in Targeting Molecular Receptors	32
Synthesis of Isatin-derived Heterocycles with Promising Anticancer Activities	31
Hydrogen-producing Photocatalyst at Sunscreen for Athletes in Preventing and Healing Muscle-nerve-skin Injuries	30
The Multitarget Action of Vitamins in the Ischemic Stroke	30
Cinchonine: A Versatile Pharmacological Agent Derived from Natural Cinchona Alkaloids	29
Insight into the Recent Developments of Nanoparticles in Treatment of Cancer and Neuro-Degenerative Disease: A Review	29
Repurposing some of the Well-known Non-steroid Anti-inflammatory Drugs (NSAIDs) for Cancer Treatment	28

Purpurogallin: A Multi-targeting Benzotropolone with Promising Anti-cancer and Chronic Disease Applications	27
Natural Multi-targets: Advances and Applications	27
Current Organoid Culture Systems in Pancreatic Cancer	26
Recent Advances in Metallic Nanostructures-assisted Biosensors for Medical Diagnosis and Therapy	25
Nutritional Value, Therapeutic Effects, Phytochemistry, and Toxicology of Lepisanthes fruticosa: A Review	25
Unlocking the Multifunctional Therapeutic Potential of Manassantin: A Lignan-Derived Scaffold	25
Bioanalysis, Analysis, Chemistry, and Pharmacological Aspects of Hypoxia-Inducible Factor Prolyl Hydroxylase Inhibitors	24
Effect of Withaferin-A, Withanone, and Caffeic Acid Phenethyl Ester on DNA Methyltransferases: Potential in Epigenetic Cancer Therapy	24
Finding Integrative Medication for Neuroblastoma and Glioblastoma through Zebrafish as A Model of Organism	23
Probing into the Flap-dimer Dynamics of the Mycobacterium tuberculosis Kasa Enzyme Binding Landscape Provides the Underlying Inhibitory Mechanisms of JSF-3285 and 5G	23
Exploring the Carbonic Anhydrase Activation Properties of 4-arylazo-3,5- diamino-1H-pyrazoles against hCA I, II, IV, and VII isoenzymes	23
Wnt/β-catenin Signaling Inhibitors	23
Exploring New Vista for Alzheimer's Disease Drug Targets	22
Oxidative Stress Biomarkers in Coronary Artery Disease	22
Precision Psychiatry: Machine Learning as a Tool to Find New Pharmacological Targets	22
Synthesis of Biorelevant Scaffolds under Greener Conditions (Part: 2)	22
Novel Biomarkers in Cardiovascular Diseases: Going beyond Troponins and Natriuretic Peptides - Part 1	22
Drug Delivery Systems for Natural Medicines in Cancer Therapy	22
Novel Therapeutic Strategies for the Management of Neuropathology and Neuroprotection in COVID-19	22
Preface	22
QSAR into the New Millennium: Structural, Topological, Quantum, Shape, Electronic and Bio Descriptors for Machine Learning & AI - Honoring Prof. Satya Prakash Gupta	22
Progress in Synthesis and Therapeutic Applications of Mefloquine: A Review	22
Biosensors in Diagnostics and Medicinal Applications Part (II)	21
Various Effects of the GABAergic System on Cancer: The Conditions and Specificities of its use in the Treatment of Some Cancers	21
Acknowledgement to Reviewers	21
Insight into Tumor Hypoxia: Radionuclide-based Biomarker as Diagnostic Tools	20
Calotropis procera (Aiton) Dryand (Apocynaceae): State of the art of its uses and Applications	20
Conformation Study and Design of Novel 6-Hydroxybenzothiazole-2- Carboxamides as Potentially Potent and Selective Monoamine Oxidase B Inhibitors for Neuroprotection	20
Recent Biochemical Advances in Antitubercular Drugs: Challenges and Future	20
Epigenetics Mechanism and Therapeutic Potential of Approved Epi-drugs in Pulmonary Hypertension Disease	19
Role of Plant Materials with Anti-inflammatory Effects in Phytotherapy of Osteoarthritis	19
Research Progress on the Synergistic Role of Gut Microbiota and Exosomal miRNAs in the Treatment of Androgenetic Alopecia	19
The Underlying Mechanism of Shanxian Granule in the Treatment of Glioma Based on Network Pharmacological and Bioinformatics Analysis	19
Rheumatoid Arthritis: Pathogenesis, Therapeutic Strategies, Advances, and Structural Activity Relationships of Synthesized Agents	19
Medicinal Chemistry and Target Identification of Synthetic Clinical and Advanced Preclinical Antimalarial Candidates (2000 - 2022)	18
Liver Cancer Bone Metastasis: Molecular Mechanisms and Therapeutic Insights	18
Small Molecule Inhibitors Targeting Pathogenic Protein Aggregation in Neurodegenerative Diseases: Medicinal Chemistry and Mechanistic Insights	18
Review on the Developments of Benzothiazole-containing Antimicrobial Agents	18
Plant-food-derived Bioactives in Managing Hypertension: From Current Findings to Upcoming Effective Pharmacotherapies	17
The Nitrite-Amines Nexus in Nitrosamine Formation: Mechanisms, Mutagenic Implications, Regulations, and Root Causes in Medicines	17
To Investigate Growth Factor Receptor Targets and Generate Cancer Targeting Inhibitors	17
Medicinal Chemistry for Sustainable Development	16
Highlighting the Therapeutic Potential of an Underexplored Target: Human Dihydroorotate Dehydrogenase in Cancer, Rheumatoid Arthritisand Sclerosis	16
An Update on Pharmacological and Phytochemical Aspects of Costus pictus D. Don - A Promising Anti-diabetic Plant	16
Recent Developments in Indazole Scaffold towards Prevention and Treatment of Various Health Disorders	16
Synthesis and Antimycobacterial Activity of Isoniazid Derivatives Tethered with Aliphatic Amines	16
Guchang Zhixie Pill: A Comprehensive Review of the Clinical Applications, Toxicological Profile, and Quality Markers	15
Recent Advances in the Multistep Continuous Preparation of APIs and Fine Chemicals	15
Advances in Small Molecules of Flavonoids for the Regulation of Gluconeogenesis	15
Lipoprotein-associated Phospholipase A2 in Coronary Artery Disease	15

The Potential of Secondary Metabolites from Plants as Drugs or Leads against Trypanosoma cruzi-An Update from 2012 to 2021	15
Isatin Derivatives as Emerging Promising Anti-Alzheimer Agents: Focusing on Their Chemical Structure and Biological Targets	15
Recent Developments in Microfluidic Paper-based Analytical Devices for Pharmaceutical Analysis	14
Recent Insights into Osimertinib Analogues against EGFR Positive Non-small Cell Lung Cancer	14
A Comprehensive Review on Phytochemistry and Pharmacology ofRosaSpecies (Rosaceae)	14
Phytochemicals of Biologically Active Fractions from Silene conoidea Leaves and Stems	14
Profiling of Polyphenolic Compounds, Antioxidant, Antidyslipidemic and Cardiac Risk Preventive Effect of Keteki Joha and Kola Joha Rice Cultivars Grown in Assam, India: A Comparative Study	14
Phytotherapeutics in Cancer: From Potential Drug Candidates to Clinical Translation	13
Multimodal Activity of a Novel Compound against Prostate and Pancreatic Cancer	13
Importance of Indazole against Neurological Disorders	13
Recent Applications of Bioinformatics in Target Identification and Drug Discovery for Alzheimer’s Disease	13
A New Advanced Approach: Design and Screening of Affinity Peptide Ligands Using Computer Simulation Techniques	13
Machine Learning and Artificial Intelligence: A Paradigm Shift in Big Data-Driven Drug Design and Discovery	13
Application of Artificial Intelligence-Based Approaches in the Discovery and Development of Protein Kinase Inhibitors (PKIs) Targeting Anticancer Activity	13
Carboxamide: A Privileged Pharmacophore for the Development of Anti-infectious and Anti-cancer Drugs	13
A Review of The Place of Adipose-Derived Stem Cells among Stem Cell Applications in Neurodegenerative Diseases	12
Acknowledgement to Reviewers	12
Advances in Anticancer Potential of Evodiamine: Insights into Structural Alteration and Nanotechnological Delivery	12
Betanin: A Natural Phytomolecule for the Intervention of Neurological Disorders	12
A Review on Indole-triazole Molecular Hybrids as a Leading Edge in Drug Discovery: Current Landscape and Future Perspectives	12
Therapeutics for the Management of Cytokine Release Syndrome in COVID-19	12
Research Progress on Membranous Nephropathy-Related Antigens and Immune-Targeted Therapy	12
A Compressive Review on Source, Toxicity and Biological Activity of Flavonoid	12
Research Progress in Chemical Synthesis and Biosynthesis of Bioactive Pyridine Alkaloids	12
Identification and Verification of a Prognostic Risk Signature in Oral Squamous Cell Carcinoma	12
LINC-PINT: A Distinctive Long Non-Coding RNA Functioning as a Potential Suppressor in Tumorigenesis	11
Development and Exploration of Organic Compounds as Aldose Reductase Inhibitors: An Overview	11
A Concise Review on the Role of Natural and Synthetically Derived Peptides in Colorectal Cancer	11
The Role of Cytokines in Activation of Tumour-promoting Pathways and Emergence of Cancer Drug Resistance	11
Medicinal Chemistry Advancement in Life-Threatening Diseases	11
A Bioengineered Wasp Venom Peptide with Antimicrobial and Anti-Inflammatory Functions	11
Hybrid Compounds in Polypharmacology	11
Pharmacological and Therapeutic Potential of Berbamine: A Potent Alkaloid from Genus Berberis	11
Impact of TRP Channels in Oral Pathology and Therapeutic Targeting Options: A Narrative Review	11
A Comprehensive Review on the Antimicrobial Activity of the Genus Artemisia, Artemisinin, and its Derivatives	11
100 Years of Insulin: A Historical Perspective	11
Alstonia boonei Promising Source of Anti-inflammatory, Antimalarial, and Ulcer Protective Agents-A Review	11
Decoding Dementia Mechanisms: Identification of Key Oligodendrocyte Associated Genes through Integrative Bioinformatics and MachineLearning	11
The Current Landscape in the Development of Small-molecule Modulators Targeting Sphingosine-1-phosphate Receptors to Treat Neurodegenerative Diseases	10
The Role of Coumarins in Drug Discovery: Pharmacological Insights and Structural Innovations	10
Antiviral Effects and Mechanisms of Green Tea Catechins on Influenza: A Perception on Combating Symptoms from COVID-19	10
Recent Advances in Drug Discovery for Parasitic Diseases	10
Navigating the Alzheimer's Treatment Landscape: Unraveling Amyloid-beta Complexities and Pioneering Precision Medicine Approaches	10
Use of Immunoglobulin Y Antibodies: Biosensor-based Diagnostic Systems and Prophylactic and Therapeutic Drug Delivery Systems for Viral Respiratory Diseases	10
Current Updates on Recent Developments in Artificial Intelligence in QSAR Modelling for Drug Discovery against Lung Cancer	10
Phytochemicals for Human Health: The Emerging Trends and Prospects, Part-2	10
Non-vesicular Lipid Transport Machinery in Trichomonas vaginalis: Novel Drug Targets against Trichomoniasis	10
Thermally-Induced Self-Agglomeration: Method and First Approaches to the Structural, Mechanical and Biological Characterization of Nanofiber Scaffolds	10
An Overview on Antifilarial Efficacy of Heterocyclic Motifs Encompassing Synthetic Strategies, SAR and Commercialized Medications	10
Roles of C/EBPβ/AEP in Neurodegenerative Diseases	10
Neuroactive Phytoconstituents of Glycyrrhiza glabra for the Treatment of Alzheimer’s Disease	10
4-Nerolidylcatechol (4-NC) and Docetaxel Synergize in Controlling Androgen- independent Prostate Cancer Cells	10
Antiproliferative Activity and Mechanisms of Action of Plant-derived Flavonoids on Breast Cancer	10
Employing “Red Flags” to Fight the Most Neglected Diseases: Nitroaromatic as Still Suitable Tools to Treat Human and Veterinary Parasitosis	10
Recent Strategies and Challenges in Immunity and Nanomaterials for Cancer Therapy	10
Physicochemical Significance of Topological Indices: Importance in Drug Discovery Research	10
Neuroprotective Role of Phytoconstituents-based Nanoemulsion for the Treatment of Alzheimer’s Disease	10
Reviewing the Synthesis and Clinical Application of FDA-approved Anticancer Medications	10
Adhesion Molecules as Prognostic Biomarkers in Coronary Artery Disease	10
Multi-target Polypharmacology of 4-aminoquinoline Compounds against Malaria, Tuberculosis and Cancer	10
Noncoding RNAs in Alzheimer’s Disease: Overview of Functional and Therapeutic Significance	10
HDAC Inhibition as Neuroprotection in COVID-19 Infection	10
Heterocyclic Phytochemicals as Anticancer Agents	10
Bioassay Guided Isolation and α-Glucosidase Inhibition Studies of a New Sesquiterpene from Ochradenus aucheri	10
Advances in the Study of Halogenated Natural Products	9
Review the Role of Metabolism Reprogramming in the Pathogenesis of Post-surgical Adhesion: A New Therapeutic Strategy	9
Benzothiazole as a Promising Scaffold for the Development of Antifungal Agents	9
1,3,4-Thiadiazole as a Structural Motif: Advances in SAR, and Drug Discovery Applications	9
Discovery of Diphenylsilane Compounds as Potential Inhibitors ofZn-Metalloproteinase Thermolysin Using Artificial Neural Networks	9
A Mini Review on Pharmacological Significance of Isatin-1,2,3-Triazole Hybrids	9
Ziziphi Spinosae Semen: A Natural Herb Resource for Treating Neurological Disorders	9
Coptis Chinensis Franch: Substance Basis, Mechanism of Action and Quality Control Standard Revealed Based on the Q-marker Concept and New Strategy of Systemic Pharmacology and Biosynthesis Rese	9
Bioactive Compounds from Cyanobacteria: A Mini Review	9
Green Synthetic and Pharmacological Developments in the Hybrid Quinazolinone Moiety: An Updated Review	9
Advances in Nanomaterial-based Biosensors for Determination of Glycated Hemoglobin	9
Exploration of Computational Aids for Effective Drug Designing and Management of Viral Diseases: A Comprehensive Review	9
Naturally Occurring Steroidal Saponins as Potential Anticancer Agents: Current Developments and Mechanisms of Action	9
A Comprehensive Review on the Application of Marketed Drugs as Ligands through Metallopharmaceutics	9
The Functional Mechanism and Structure-Activity Relationship of Antibacterial Peptides	9
Psychedelics and Hallucinogens in Psychiatry: Finding New Pharmacological Targets	9

Oxazole-Based Molecules: Recent Advances on Biological Activities	9
In Silico and In Vivo Hepatorenal Protective Effect of Chitosan-Loaded Chrysin Nanoparticles in Obese Rats	9
Neurobiology of Dream Activity and Effects of Stimulants on Dream	9
Harnessing the Therapeutic Potential of Antimicrobial Peptides for Cancers: State of the Art	8
Stimuli-sensitive Chitosan-based Nanosystems-immobilized Nucleic Acids for Gene Therapy in Breast Cancer and Hepatocellular Carcinoma	8
Recent Advances in Chemical Composition and Transdermal Delivery Systems for Topical Bio-actives in Skin Cancer	8
A Comprehensive Review of the Phytochemical Constituents and Diverse Pharmacological Applications of Diospyros kaki (Persimmon) Across Traditional and Modern Medicine	8
Advancements and Scientific Partnerships in the Application of Polysaccharides in Oral Formulations: A Bibliometric Analysis and Review	8
Thiazole-Based Antioxidants: Pioneering a Decade of Therapeutic Advances	8
A Comprehensive Review of mRNA-based Vaccines for COVID-19, A New Era in Pharmaceuticals: Unspecified and Unknown Aspects, Effects and Challenges	8
Molecular Characterization of Primary and Metastatic Colon Cancer Cells to Identify Therapeutic Targets with Natural Compounds	8
Targeting Various Pathogenic Pathways for the Development of Anti-alzheimer’s Drugs: An Update	8
Nano-cocrystals as Nanotechnology-based Approach to Modulate Solubility and Bioavailability of Poorly Soluble Drugs	8
Synthesis, X-Ray Structure, Characterization, Antifungal Activity, DFT, and Molecular Simulation of a Novel Pyrazole Carboxylic Acid	8
Unveiling Anti-Cancer Potential through ADMET Prediction, Molecular Docking, Molecular Dynamics, and In vitro Analysis: Approach to Establish Alpha-Terpineol as a Potential Drug Candidate against Glio	8
Transforming Breast Cancer Therapy: The Pivotal Role of Nanoparticles	8
Targeting c-Met in Cancer Therapy: Unravelling Structure-activity Relationships and Docking Insights for Enhanced Anticancer Drug Design	8
Mining of Targeted Therapeutic Drugs for Hepatocellular Carcinoma based on Programmed Cell Death-related Features and Construction of an Imaging Histology Diagnostic Model	8
Biofunctionalized Nano-antimicrobials - Progress, Prospects and Challenges	8
FDA-Approved Fluorine-Containing Molecules in 2024: Significance, Synthesis, and Therapeutic Applications	8
A Review on Aptamers Selection and Application in Heart Diseases Diagnosis	8
Exploring the Structure-Activity Relationship of COX Inhibitors with Anticancer Effects: A Comprehensive Review	8
An Updated Overview of Synthetic α-glucosidase Inhibitors: Chemistry and Bioactivities	8
Therapeutic Potential of Quercetin in Diabetic Neuropathy and Retinopathy: Exploring Molecular Mechanisms	8
Recent Development of Heterocyclic Compounds with Indazole Moiety as Potential Antiparasitic Agents	8
The Vital Role of Long Non-Coding RNA SUMO1P3 in the Regulation of Human Cancer: Current Perspectives and Future Challenges	8
Nanomaterial-based Electrochemical Sensors for Multiplex Medicinal Applications	8
Zingerone Induces Apoptosis and Ferroptosis in Prostate Cancer DU145 Cells	8
A Review of Computational Approaches Targeting SARS-CoV-2 Main Protease to the Discovery of New Potential Antiviral Compounds	8
Quantitative Structure Activity/Toxicity Relationship through Neural Networks for Drug Discovery or Regulatory Use	8
Thiazolidine Derivatives: An Up-to-Date Review of Synthesis and Biological Activity	8
Exploring the Therapeutic Potential and Underlying Mechanism of Callerya speciosa in Ankylosing Spondylitis: Network Pharmacology, Molecular Docking, and Single-Cell Sequencing	8
Recent Advances in Di-, Tri-Substituted Mono-Thiazoles, and Bis-Thiazoles: Factors Affecting Biological Activities, Future Aspects, and Challenges	8
Coumarin as a Privileged and Medicinally Important Scaffold in the Treatment of Tuberculosis	7
Pharmacological Chemistry and Biomedical Implications of Chemical Ingredients from Parthenium hysterophorus	7
Non-fused Pyrimidine Derivatives as Potential Pharmacological Entities: A Review	7
Melanin Synthesized by the Endophytic Aureobasidium Pullulans AKW: A Multifaceted Biomolecule with Antioxidant, Wound Healing, and Selective Anti-Cancer Activity	7
Ethnobotanical Study of Knowledge and Herbal Recipes of Medicinal Plants in Ancient Izki, Al Dakhliya Region, Sultanate of Oman	7
The Computational Tools to Identify DNA Repeats and Motifs: A Systematic Review	7
Pharmacodynamic Interactions: Mechanisms, Clinical Trial Insights, and Patent Perspectives	7
Natural Antioxidants as Additional Weapons in the Fight against Malarial Parasite	7
Mechanisms of Metallic Nanomaterials to Induce an Antibacterial Effect	7
Viral Vertical Transmission through the Placenta: The Potential of Natural Products as Therapeutic and Prophylactic Antiviral Agents	7
5-Membered Heterocyclic Compounds as Antiviral Agents	7
Natural-Derived Products and Nanomaterials for the Treatment of Cancer and Chronic Disorders (Part 1)	7
Electrochemical Protein-based Bioanalytical Devices for Drug Analysis	7
Research Progress on the Mechanisms of Traditional Chinese Medicine in Preventing and Treating HCC Invasion and Metastasis Based on Lipid Metabolic Reprogramming	7
Clinical Research Progress of BTK Inhibitors in the Treatment of Autoimmune Diseases	7
Recent Advances in Nanocatalyzed One-Pot Sustainable Synthesis of Bioactive N, N-Heterocycles with Anticancer Activities: An Outlook of Medicinal Chemistry	7
The Impact and Role of Artificial Intelligence (AI) in Healthcare: Systematic Review	7
Recent Advances in the Development of Nitrogen-containing Heterocyclic Anti-alzheimer’s Agents	7
Ameliorative Effects of Essential Oils on Diabetes Mellitus: A Review	7
CADD Methods for Developing Novel Compounds Synthesized to Inhibit Tyrosine Kinase Receptors	7
Polymer Conjugate as the New Promising Drug Delivery System for Combination Therapy against Cancer	7