Current Topics in Medicinal Chemistry

Article	Citations
Withdrawal Notice: Roles of Aryl-hydrocarbon Receptor in Metabolism and Proliferative Behaviors Of Bone Marrow Mscs: Implications For Targeted Therapy	108
Employing “Red Flags” to Fight the Most Neglected Diseases: Nitroaromatic as Still Suitable Tools to Treat Human and Veterinary Parasitosis	59
Osseointegration Process Improving via Functionalization of Titanium Dioxide Nanotubes: A Bibliometric Analysis and Systematic Review	57
Advances in the Study of Halogenated Natural Products	55
Synthesis and Evaluation of Coumarin Clubbed Sulfanilamide and 2-Aminobenzothiazole Hybrids for Antibacterial Applications	42
Development and Advances of Drugs for Cancer Theranostics – PART-IV	40
Genistein as a Chemo-modulatory Agent: Exploring its Potential in Chemosensitization and Combinatorial Therapeutic Strategies for Cancer Treatment	39
Green Synthetic and Pharmacological Developments in the Hybrid Quinazolinone Moiety: An Updated Review	37
Eco-friendly Approaches to Chromene Derivatives: A Comprehensive Review of Green Synthesis Strategies	37
Heterocyclic Phytochemicals as Anticancer Agents	35
Recent Advances in the Development of Greener Methodologies for the Synthesis of Benzothiazoles	35
The Role of Herbal Medicine in Modulating Bone Homeostasis	33
A Review on Natural Sources Derived Protein Nanoparticles as Anticancer Agents	32
Exploring the Therapeutic Potential of Glycyrrhiza Compounds in Alzheimer's Disease: A Comprehensive Review	31
Navigating the Alzheimer's Treatment Landscape: Unraveling Amyloid-beta Complexities and Pioneering Precision Medicine Approaches	31
Phytochemicals for Human Health: The Emerging Trends and Prospects, Part-2	29
Bioassay Guided Isolation and α-Glucosidase Inhibition Studies of a New Sesquiterpene from Ochradenus aucheri	29
Valeriana jatamansi: Bioactive Compounds and their Medicinal Uses	28
Cruzain and Rhodesain Inhibitors: Last Decade of Advances in Seeking for New Compounds Against American and African Trypanosomiases	27
Ciprofloxacin and Norfloxacin Hybrid Compounds: Potential Anticancer Agents	27
Privileged Scaffold for Drug Design and Activity Improvement - Part IV	23
Biosensors in Diagnostics and Medicinal Applications	23
Natural Products: What can Nature Offer for the Promotion of Health?	23
Data Mining of Differentially Expressed Genes in Ovarian Epithelial Carcinoma: Implications in Precise Medicine	23
Recent Developments in the Therapeutics for Endocrine Diseases	23

Recent Advances in Drug Discovery for Parasitic Diseases	23
Ternary System of Bacogenins with Fulvic Acid and Hydrogenated Soy Lecithin: Preparation, Characterization and,In vivoStudies	22
Phytochemistry and Polypharmacological Potential of Colebrookea oppositifolia Smith	22
Design of Novel Phosphopantetheine Adenylyltransferase Inhibitors: A Potential New Approach to Tackle Mycobacterium tuberculosis	22
Advances in Nanomaterial-based Biosensors for Determination of Glycated Hemoglobin	22
Tetrandrine for Targeting Therapy Resistance in Cancer	22
Insight of Engineered Nano-based Biologics Approaches used to Combat Autoimmune Disease using TNF-α & IL Inhibitors	22
New Approaches and Advancements in Drug Development from Phenolic P-coumaric Acid	21
Synthesis of Isatin-derived Heterocycles with Promising Anticancer Activities	21
Non-vesicular Lipid Transport Machinery in Trichomonas vaginalis: Novel Drug Targets against Trichomoniasis	21
Green Synthesis of Biorelevant Scaffolds through Organocatalytic/ Enzymatic Dynamic Kinetic Resolution	21
Computer-Aided Drug Design for Combating Diseases (Part-IV)	20
Multi-target Polypharmacology of 4-aminoquinoline Compounds against Malaria, Tuberculosis and Cancer	20
Natural Bioactive as a Potential Therapeutic Approach for the Management of Cyclophosphamide-induced Cardiotoxicity	20
Phytochemicals from Natural Products for the Prevention and Treatment of Non-communicable Diseases	19
Study on Molecular Anti-tumor Mechanism of 2-Thiohydantoin Derivative based on Molecular Docking and Bioinformatic Analyses	19
Revolutionizing Cancer Treatment: Harnessing the Power of Mesenchymal Stem Cells for Precise Targeted Therapy in the Tumor Microenvironment	18
Phytochemicals for Cancer Treatment: An Update on Plant-Derived Anti-Cancer Compounds and their Mechanisms of Action	18
Recent Advances of α-Glucosidase Inhibitors: A Comprehensive Review	18
Review on the Discovery of Water Absorbance Spectral Pattern in Aquaphotomics based on Chemometrics Analytical Tools	18
Natural Bioactive Compounds from Medicinal Plants as Antibacterial Drugs: Mechanism Insights and Clinical Perspectives	18
Psychedelics and Hallucinogens in Psychiatry: Finding New Pharmacological Targets	18
Nano-nutraceuticals to Combat Oxidative Stress: Unlocking Newer Paradigms in Adjuvant Therapy	17
Benzimidazole as a Privileged Scaffold in Drug Design and Discovery	17
Review the Role of Metabolism Reprogramming in the Pathogenesis of Post-surgical Adhesion: A New Therapeutic Strategy	17
QSAR Studies to Predict Activity of HSP90 Inhibitors	17
Trends of Pharmaceutical Design of Endophytes as Anti-infective	17
Recent Strategies and Challenges in Immunity and Nanomaterials for Cancer Therapy	17
Advances in Drug Discovery based on Genomics, Proteomics and Bioinformatics	17
Repurposing of Plant-based Antiviral Molecules for the Treatment of COVID-19	17
Recent Progress on the Role of Fibronectin in Tumor Stromal Immunity and Immunotherapy	17
Recent Advances in Computer Aided Drug Design	16
Transition Metal-mediated Uncaging Chemistry in Prodrug Design	16
Stimulants and Depressor Drugs in the Sleep-wake Cycle Modulation: The Case of Alcohol and Cannabinoids	16
Larrea tridentata and its Biological Activities	16
Anti-breast Cancer Potential of Natural and Synthetic Coumarin Derivatives	16
Traditional uses, Phytochemistry, Pharmacology, and Toxicology of the GenusArtemisia L. (Asteraceae): A High-value Medicinal Plant	16
Harnessing Natural Resources for Advancements in Dengue Virus Treatment	16
Recent Advances in the Use of Multitarget Therapeutics	15
New Experimental and Computational Tools for Drug Discovery. Part – XII	15
4D-QSAR Models Applied to the Study of TGF- β1 Receptor Inhibitors	15
Piperidine Nucleus as a Promising Scaffold for Alzheimer’s Disease: Current Landscape and Future Perspective	15
The Role of Flavonoids in Inhibiting IL-6 and Inflammatory Arthritis	15
The Unveiling of Therapeutic Targets for Alzheimer’s Disease: An Integrative Review	15
Flavonoids as Sirtuin Modulators	14
Exploration of Computational Aids for Effective Drug Designing and Management of Viral Diseases: A Comprehensive Review	14
Adhesion Molecules as Prognostic Biomarkers in Coronary Artery Disease	14
Exploring the Role of Antioxidants to Combat Oxidative Stress in Malaria Parasites	14
1,3,4-Oxadiazoles as Potential Pharmacophore for Cytotoxic Potentiality: A Comprehensive Review	14
Imidazole Scaffold Based Compounds in the Development of Therapeutic Drugs	14

The Functional Mechanism and Structure-Activity Relationship of Antibacterial Peptides	13
SARS-CoV-2 Omicron Variant in Medicinal Chemistry Research	13
Recent Advances in Diosmetin: Pharmacological, Pharmacokinetic, and Toxicological Profile	13
A Pharmacological Update of Oxadiazole Derivatives: A Review	13
Flavonoid: A Natural Scaffold with Modulatory Activities on Diverse Cellular Signaling Pathways Related to Complex Diseases	13
“Big Three” Infectious Diseases: Tuberculosis, Malaria and HIV/AIDS	12
Tackling Nontuberculous Mycobacteria by Repurposable Drugs and Potential Leads from Natural Products	12
The Role of METTL3 in the Progression of Cardiac Fibrosis	12
From Nature to Drug: Overview and CADD Approach of Anacardic Acid to Propose their Biological Potential	12
The Influence of Thyroid Hormone on Ca 2+ Signaling Pathways During Embryonal Development	12
Fighting Antimicrobial Resistance with Natural Products - Current Developments and Future Prospects	12
The Medicinal Chemistry of 3-nitro-1,2,4-triazoles: Focus on Infectious Diseases	12
Sterol 14α-Demethylase from Trypanosomatidae Parasites as a Promising Target for Designing New Antiparasitic Agents	12
Nanogel-based Transdermal Drug Delivery System: A Therapeutic Strategy with Under Discussed Potential	12
Current Scenario of Acridine Hybrids with Anticancer Potential	12
Naphthoquinone Derivatives Targeting Melanoma	12
Computational Approaches in the Discovery and Development of Therapeutic and Prophylactic Agents for Viral Diseases	12
Ligand-Based Approach for Multi-Target Drug Discovery: PTML Modeling of Triple-Target Inhibitors	11
Triazole scaffold-based DPP-IV Inhibitors for the management of Type-II Diabetes Mellitus: Insight into Molecular Docking and SAR	11
Neurochemistry of Psychosis	11
The Gut Microbiota-Brain Axis: Potential Mechanism of Drug Addiction	11
Computer-aided Drug Discovery of Epigenetic Modulators in Dual-target Therapy of Multifactorial Diseases	11
Antiproliferative Activity and Mechanisms of Action of Plant-derived Flavonoids on Breast Cancer	11
Thiazole-based Chalcone Derivatives as Potential Anti-inflammatory Agents: Biological Evaluation and Molecular Modelling	11
Cellular Bioenergetic and Metabolic Changes in Patients with Autism Spectrum Disorder	11
An Overview on Antifilarial Efficacy of Heterocyclic Motifs Encompassing Synthetic Strategies, SAR, and Commercialized Medications	11
Envelope Protein in Differential Serodiagnosis of Dengue, Zika, and Chikungunya Viruses: A Systematic Review	11
Therapeutic Potential of Indole Derivatives as Anti-HIV Agents: A Mini-review	11
Platinum-based Anticancer Drugs: Unveiling Novel Mechanisms of Action of Conventional Metallodrugs for Improved Therapies	10
Current Knowledge Regarding Pharmacological Profile and Chemical Constituents of Gynura procumbens	10
Stimuli-induced NOergic Molecules and Neuropeptides Mediated Axon Reflexes Contribute to Tracers along Meridian Pathways	10
Immunomodulatory Effects of Allium sativum L. and its Constituents against Viral Infections and Metabolic Diseases	10
Protease Inhibitors as Promising Weapons against COVID-19: Focus on Repurposing of Drugs used to Treat HIV and HCV Infections	10
The Bioactive Potential of Culturable Fungal Endophytes Isolated From the Leaf of Catharanthus roseus (L.) G. Don	10
Co-administration of Pterocarpus marsupium Extract and Glibenclamide Exhibits Better Effects in Regulating Hyperglycemia and Associated Changes in Alloxan-induced Diabetic Mice	10
Brevifoliol and its Analogs: A New Class of Anti-tubercular Agents	10
HDAC Inhibition as Neuroprotection in COVID-19 Infection	10
Moxifloxacin Derivatives with Potential Antibacterial Activity against Methicillin- Resistant Staphylococcus Aureus (MRSA)	10
Bibliometric Analysis: Nanotechnology and COVID-19	10
Use of Immunoglobulin Y Antibodies: Biosensor-based Diagnostic Systems and Prophylactic and Therapeutic Drug Delivery Systems for Viral Respiratory Diseases	10
The Insights and Perspectives of Nitric Oxide-mediated Biofilm Eradication	10
Application of Virtual Sample Generation and Screening in Process Parameter Optimization of Botanical Medicinal Materials	10
Flavonoids: The Innocuous Agents Offering Protection against Alzheimer’s Disease Through Modulation of Proinflammatory and Apoptotic Pathways	9
Cordia Dichotoma: A Comprehensive Review of its Phytoconstituents and Endophytic Fungal Metabolites and their Potential Anticancer Effects	9
Surface Functionalization of Extracellular Vesicles with Nucleic Acids towards Biomedical Applications	9
A Review on Medicinal Approaches of Novel Imatinib Derivatives	9
In silico Strategy: A Promising Implement in the Development of Multitarget Drugs against Neurodegenerative Diseases	9
Privileged Scaffolds Targeting Bromodomain-containing Protein 4	9
Application and SARs of Pyrazolo[1,5-a]pyrimidine as Antitumor Agents Scaffold	9
A Mini Review on Pharmacological Significance of Isatin-1,2,3-Triazole Hybrids	9
A Comprehensive Review on the Development of Titanium Complexes as Cytotoxic Agents	9
Noncoding RNAs in Alzheimer’s Disease: Overview of Functional and Therapeutic Significance	9
Benzimidazole Derivatives in Breast Cancer: Target-Specific Therapeutic Breakthroughs	9
Understanding the Phytoestrogen Genistein Actions on Breast Cancer: Insights on Estrogen Receptor Equivalence, Pleiotropic Essence and Emerging Paradigms in Bioavailability Modulation	9
Neuroactive Phytoconstituents of Glycyrrhiza glabra for the Treatment of Alzheimer’s Disease	9
Naturally Occurring Steroidal Saponins as Potential Anticancer Agents: Current Developments and Mechanisms of Action	8
Resveratrol and Colorectal Cancer: A Molecular Approach to Clinical Researches	8
Multicomponent Reactions Applied to Total Synthesis of Biologically Active Molecules: A Short Review	8
Quinolone Derivatives as Anticancer Agents: Importance in Medicinal Chemistry	8
Thymol-Loaded Zinc Ferrite Nanoparticles: A Novel Carrier for Enhanced Antimicrobial and Antibiofilm Activity against M. smegmatis through ROS-Mediated Mechanism	8
A Review of Computational Approaches Targeting SARS-CoV-2 Main Protease to the Discovery of New Potential Antiviral Compounds	8
Natural Molecules as Talented Inhibitors of Nucleotide Pyrophosphatases/ Phosphodiesterases (PDEs)	8
An Overview of Ovarian Cancer: Molecular Processes Involved and Development of Target-based Chemotherapeutics	8
Potential Anti-tumor Effects and Apoptosis-inducing Mechanisms of Saponins: A Review	8
Current Status of Novel Pyridine Fused Derivatives as Anticancer Agents: An Insight into Future Perspectives and Structure Activity Relationship (SAR)	8
The Antibacterial Activity of Quinazoline and Quinazolinone Hybrids	8
4-Nerolidylcatechol (4-NC) and Docetaxel Synergize in Controlling Androgen- independent Prostate Cancer Cells	8
The Design of Multi-target Drugs to Treat Cardiovascular Diseases: Two (or more) Birds on One Stone	8
Juglone: A Versatile Natural Platform for Obtaining New Bioactive Compounds	8
Privileged Scaffold for Drug Design and Activity Improvement - Part III	8
Targeted Cancer Stem Cell Therapeutics: An Update	8
Benzothiazole as a Promising Scaffold for the Development of Antifungal Agents	8
Quinoline as a Privileged Structure: A Recent Update on Synthesis and Biological Activities	8
Coptis Chinensis Franch: Substance Basis, Mechanism of Action and Quality Control Standard Revealed Based on the Q-marker Concept and New Strategy of Systemic Pharmacology and Biosynthesis Rese	8
PROTAC Beyond Cancer- Exploring the New Therapeutic Potential of Proteolysis Targeting Chimeras	8
Eugenol as a Potential Drug Candidate: A Review	8
Improving ADMET Prediction Accuracy for Candidate Drugs: Factors to Consider in QSPR Modeling Approaches	8
Anxiolytic and Antidepressant-like Effects of Monoterpene Tetrahydrolinalool andIn silicoApproach of new Potential Targets	8
Next-generation Bruton’s Tyrosine Kinase (BTK) Inhibitors Potentially Targeting BTK C481S Mutation- Recent Developments and Perspectives	8
Phytochemicals-based Therapeutics against Alzheimer's Disease: An Update	8

Role of Ubiquitin-specific Proteases in Hepatocellular Carcinoma Pathogenesis	8
Tumor-associated Macrophages (TAMs) in Cancer Resistance; Modulation by Natural Products	8
Ziziphi Spinosae Semen: A Natural Herb Resource for Treating Neurological Disorders	8
Aminoglycosides with Anti-MRSA Activity: A Concise Review	8
Deciphering Tuberculous Meningitis: From Clinical Challenges to Novel Models and Pathogenic Pathways	7
Advancement in Nanoparticle-based Biosensors for Point-of-care In vitro Diagnostics	7
Chemotherapeutics against Infectious Diseases: Syntheses and Biological Targets - Part 1	7
Multilevel Pharmacological Effects of Antipsychotics in Potential Glioblastoma Treatment	7
Recent Molecular Targets and their Ligands for the Treatment of Alzheimer Disease	7
Design and Synthesis of 1-(4-Bromo-2-(Pyrrolidine-1-Yl) Benzyl) Piperidine-Based Derivatives as Anti-Tubulin Agents	7
Bioactivity of Natural Products as Complementary Medicine	7
Phytochemical Profile and Antioxidant and Protective Activities of Various Types of Extracts from Hyssopus officinalis L. and Grindelia robusta Nutt. Herb Grown in Poland	7
Recent Medicinal Chemistry Studies against Neglected Diseases	7
Review on Structural Trends and Chemotaxonomical Aspects of Pharmacologically Evaluated Flavonoids	7
Recent Advances in the Design and Synthesis of Small Molecule Carbonic Anhydrase IX Inhibitors	7
Biological Cargo: Exosomes and their Role in Cancer Progression and Metastasis	7
Recent Advances in Drug Discovery and Treatment of Neglected Diseases	7
Updates on Intrinsic Medicinal Chemistry of 1,4-dihydropyridines, Perspectives on Synthesis and Pharmacokinetics of Novel 1,4-dihydropyrimidines as Calcium Channel Blockers: Clinical Pharmacology	7
Current Trends in the Development of Electrochemical Sensors and Biosensors for Biomolecule Analysis (Part II)	7
Impact of Cannabinoid Receptors in the Design of Therapeutic Agents against Human Ailments	7
Current Advances in Drug Design and Cancer Research	7
Current Trends in Enzyme Inhibition and Docking Analysis in Drug Design-Part -III	7
Recent Development of Heterocyclic Compounds with Indazole Moiety as Potential Antiparasitic Agents	7
The Multitarget Action of Vitamins in the Ischemic Stroke	7
Effect of Withaferin-A, Withanone, and Caffeic Acid Phenethyl Ester on DNA Methyltransferases: Potential in Epigenetic Cancer Therapy	7
In silico Methods for Drug Design	7
The Anti-Leukemic Activities of Campesterol and Α-Tocopherol Against BCL-2 Target through Computational Drug Design Approaches	7
Computational Analysis of Gastric Canceromics Data to Identify Putative Biomarkers	6
Neurobiochemical Disturbances in Psychosis and their Implications for Therapeutic Intervention	6
Actinomycetes - The Repertoire of Diverse Bioactive Chemical Molecules: From Structures to Antibiotics	6
Contribution of Transcriptome to Elucidate the Biology of Plasmodium spp	6
Natural Multi-targets: Advances and Applications	6
The Applications of 2D Materials for Electrochemical Biosensing, Drug Delivery, and Environmental Monitoring	6
Update on Modulators of Quorum Sensing Pathways in Pseudomonas aeruginosa	6
Alleviating Neurodegenerative Diseases Associated with Mitochondrial Defects by Therapeutic Biomolecules	6
Immunomodulatory Effect of Phytoactive Compounds on Human Health: A Narrative Review Integrated with Bioinformatics Approach	6
Nutritional Value, Therapeutic Effects, Phytochemistry, and Toxicology of Lepisanthes fruticosa: A Review	6
Bioanalysis, Analysis, Chemistry, and Pharmacological Aspects of Hypoxia-Inducible Factor Prolyl Hydroxylase Inhibitors	6
Hydrogen-producing Photocatalyst at Sunscreen for Athletes in Preventing and Healing Muscle-nerve-skin Injuries	6
New Experimental and Computational Tools for Drug Discovery: Part - XI	6
Recent Advances on Small Molecule Medicinal Chemistry to Treat Human Diseases - Part IV	6
Promising Marine Natural Products for Tackling Viral Outbreaks: A Focus on Possible Targets and Structure-activity Relationship	6
Recent Advances in Metallic Nanostructures-assisted Biosensors for Medical Diagnosis and Therapy	6
Neurobiology of Dream Activity and Effects of Stimulants on Dream	6
Nitrosamine Impurities in Pharmaceuticals: An Empirical Review of their Detection, Mechanisms, and Regulatory Approaches	6
Advancements in Computational Approaches for Antidiabetic Drug Discovery: A Review	6
Traditional Chinese Medicine for Liver Cancer Treatment: Network Pharmacology Research	6
Phenolic Acids - Versatile Natural Moiety with Numerous Biological Applications	6
Corrigendum to: Computational Modeling of Environmental Co-exposure on Oil-Derived Hydrocarbon Overload by Using Substrate-Specific Transport Protein (TodX) with Graphene Nanostructures	6
Natural Products: Reasons for not Underestimating Them- Part II	6
Oxyprenylated Secondary Metabolites as Modulators of Lipid and Sugar Metabolism	6
Recent Development of Hydrogen Sulfide Therapeutics in the Treatment of Cardiovascular Diseases	6
Recent Trends in Cancer Management	6
A New Approach to Melanoma Treatment: microRNAs	6
Computer-aided Drug Design against Emerging Viruses: Part II	6
Relevance of Aromatase Inhibitors in Breast Cancer Treatment	6
A Comprehensive Review of mRNA-based Vaccines for COVID-19, A New Era in Pharmaceuticals: Unspecified and Unknown Aspects, Effects and Challenges	6
Navigating Molecular Pathways: An Update on Drugs in Colorectal Cancer Treatment	6
Antimalarials Targeting the Malaria Parasite Cation ATPase P. falciparum ATP4 (PfATP4)	6