Current Topics in Medicinal Chemistry

Article	Citations
Privileged Scaffold for Drug Design and Activity Improvement - Part IV	61
Recent Developments in the Therapeutics for Endocrine Diseases	59
Recent Advances in the Use of Multitarget Therapeutics	54
Valeriana jatamansi: Bioactive Compounds and their Medicinal Uses	52
Computer-aided Drug Discovery of Epigenetic Modulators in Dual-target Therapy of Multifactorial Diseases	50
Discovery of MMP1 Inhibitors from Dandelion using Molecular Simulation and Bioactivity Test	48
Qi Yin San Liang San Decoction Relieves Gefitinib-Induced Diarrhea via the Modulation of Chemokines and Innate Immune Responses	45
Next-generation Bruton’s Tyrosine Kinase (BTK) Inhibitors Potentially Targeting BTK C481S Mutation- Recent Developments and Perspectives	44
Ethyl Acetate Extract from Wenxia Formula (WFEA) Attenuates Immunosuppression in Lung Cancer by Inhibiting Treg Differentiation via Blockade of TGF-Β/Smad Signaling	43
The Gut Microbiota-Brain Axis: Potential Mechanism of Drug Addiction	38
Tackling Nontuberculous Mycobacteria by Repurposable Drugs and Potential Leads from Natural Products	36
Green Synthesis of Biorelevant Scaffolds through Organocatalytic/ Enzymatic Dynamic Kinetic Resolution	35
Fighting Antimicrobial Resistance with Natural Products - Current Developments and Future Prospects	34
Synthesis of Isatin-derived Heterocycles with Promising Anticancer Activities	34
Modern Approaches to Diabetes: The Role of Phytochemicals inTargeting Molecular Receptors	33
Optimization, Preparation, and Cytotoxic Potential of Pyrus communisExtract Loaded Ethosomes on Skin Cancer Cell Lines	33
From Nature to Drug: Overview and CADD Approach of Anacardic Acid to Propose their Biological Potential	32
Eco-friendly Approaches to Chromene Derivatives: A Comprehensive Review of Green Synthesis Strategies	32
The Role of Herbal Medicine in Modulating Bone Homeostasis	31
Application of Virtual Sample Generation and Screening in Process Parameter Optimization of Botanical Medicinal Materials	31
Bioanalysis, Analysis, Chemistry, and Pharmacological Aspects of Hypoxia-Inducible Factor Prolyl Hydroxylase Inhibitors	31
Effect of Withaferin-A, Withanone, and Caffeic Acid Phenethyl Ester on DNA Methyltransferases: Potential in Epigenetic Cancer Therapy	29
The Multitarget Action of Vitamins in the Ischemic Stroke	29
Recent Advances in the Design and Synthesis of Small Molecule Carbonic Anhydrase IX Inhibitors	28
Current Organoid Culture Systems in Pancreatic Cancer	27

Exploring the Carbonic Anhydrase Activation Properties of 4-arylazo-3,5- diamino-1H-pyrazoles against hCA I, II, IV, and VII isoenzymes	27
Recent Advances in Metallic Nanostructures-assisted Biosensors for Medical Diagnosis and Therapy	27
Nutritional Value, Therapeutic Effects, Phytochemistry, and Toxicology of Lepisanthes fruticosa: A Review	27
Natural Multi-targets: Advances and Applications	27
Unlocking the Multifunctional Therapeutic Potential of Manassantin: A Lignan-Derived Scaffold	27
Hydrogen-producing Photocatalyst at Sunscreen for Athletes in Preventing and Healing Muscle-nerve-skin Injuries	26
Insight into the Recent Developments of Nanoparticles in Treatment of Cancer and Neuro-Degenerative Disease: A Review	26
Repurposing some of the Well-known Non-steroid Anti-inflammatory Drugs (NSAIDs) for Cancer Treatment	26
Cinchonine: A Versatile Pharmacological Agent Derived from Natural Cinchona Alkaloids	25
Finding Integrative Medication for Neuroblastoma and Glioblastoma through Zebrafish as A Model of Organism	25
Probing into the Flap-dimer Dynamics of the Mycobacterium tuberculosis Kasa Enzyme Binding Landscape Provides the Underlying Inhibitory Mechanisms of JSF-3285 and 5G	25
Wnt/β-catenin Signaling Inhibitors	25
Epigenetics Mechanism and Therapeutic Potential of Approved Epi-drugs in Pulmonary Hypertension Disease	24
Novel Biomarkers in Cardiovascular Diseases: Going beyond Troponins and Natriuretic Peptides - Part 1	24
Novel Therapeutic Strategies for the Management of Neuropathology and Neuroprotection in COVID-19	23
Exploring New Vista for Alzheimer's Disease Drug Targets	23
Acknowledgements to Reviewers	23
Synthesis of Biorelevant Scaffolds under Greener Conditions (Part: 2)	22
Medicinal Chemistry and Target Identification of Synthetic Clinical and Advanced Preclinical Antimalarial Candidates (2000 - 2022)	21
Liver Cancer Bone Metastasis: Molecular Mechanisms and Therapeutic Insights	21
Effects of Flavonoids in Experimental Models of Arterial Hypertension	21
Insight into Tumor Hypoxia: Radionuclide-based Biomarker as Diagnostic Tools	21
Calotropis procera (Aiton) Dryand (Apocynaceae): State of the art of its uses and Applications	21
Chemical Composition, Acetylcholine Esterase and Anti-bacterial Activities of Essential Oils of Elaeosilenum thapsioides (Desf.) Maire from Algeria	21
Acknowledgement to Reviewers	21
Conformation Study and Design of Novel 6-Hydroxybenzothiazole-2- Carboxamides as Potentially Potent and Selective Monoamine Oxidase B Inhibitors for Neuroprotection	21
Oxidative Stress Biomarkers in Coronary Artery Disease	20
Biosensors in Diagnostics and Medicinal Applications Part (II)	19
PREFACE	19
Highlighting the Therapeutic Potential of an Underexplored Target: Human Dihydroorotate Dehydrogenase in Cancer, Rheumatoid Arthritisand Sclerosis	19
Precision Psychiatry: Machine Learning as a Tool to Find New Pharmacological Targets	19
Various Effects of the GABAergic System on Cancer: The Conditions and Specificities of its use in the Treatment of Some Cancers	19
The Nitrite-Amines Nexus in Nitrosamine Formation: Mechanisms, Mutagenic Implications, Regulations, and Root Causes in Medicines	19
Progress in Synthesis and Therapeutic Applications of Mefloquine: A Review	19
Plant-food-derived Bioactives in Managing Hypertension: From Current Findings to Upcoming Effective Pharmacotherapies	18
QSAR into the New Millennium: Structural, Topological, Quantum, Shape, Electronic and Bio Descriptors for Machine Learning & AI - Honoring Prof. Satya Prakash Gupta	18
Role of Plant Materials with Anti-inflammatory Effects in Phytotherapy of Osteoarthritis	18
To Investigate Growth Factor Receptor Targets and Generate Cancer Targeting Inhibitors	18
Recent Biochemical Advances in Antitubercular Drugs: Challenges and Future	18
Rheumatoid Arthritis: Pathogenesis, Therapeutic Strategies, Advances, and Structural Activity Relationships of Synthesized Agents	18
Drug Delivery Systems for Natural Medicines in Cancer Therapy	18
Recent Developments in Indazole Scaffold towards Prevention and Treatment of Various Health Disorders	17
Advances in Small Molecules of Flavonoids for the Regulation of Gluconeogenesis	17
Review on the Developments of Benzothiazole-containing Antimicrobial Agents	17
Medicinal Chemistry for Sustainable Development	17
Preface	17
Synthesis and Antimycobacterial Activity of Isoniazid Derivatives Tethered with Aliphatic Amines	17
Recent Insights into Osimertinib Analogues against EGFR Positive Non-small Cell Lung Cancer	16
The Potential of Secondary Metabolites from Plants as Drugs or Leads against Trypanosoma cruzi-An Update from 2012 to 2021	16
Phytochemicals of Biologically Active Fractions from Silene conoidea Leaves and Stems	16

Carboxamide: A Privileged Pharmacophore for the Development of Anti-infectious and Anti-cancer Drugs	16
Lipoprotein-associated Phospholipase A2 in Coronary Artery Disease	16
An Update on Pharmacological and Phytochemical Aspects of Costus pictus D. Don - A Promising Anti-diabetic Plant	16
Isatin Derivatives as Emerging Promising Anti-Alzheimer Agents: Focusing on Their Chemical Structure and Biological Targets	16
Self-assembled Nucleic Acid Nanostructures for Biomedical Applications	16
A Review on Indole-triazole Molecular Hybrids as a Leading Edge in Drug Discovery: Current Landscape and Future Perspectives	15
Guchang Zhixie Pill: A Comprehensive Review of the Clinical Applications, Toxicological Profile, and Quality Markers	15
Recent Developments in Microfluidic Paper-based Analytical Devices for Pharmaceutical Analysis	15
Profiling of Polyphenolic Compounds, Antioxidant, Antidyslipidemic and Cardiac Risk Preventive Effect of Keteki Joha and Kola Joha Rice Cultivars Grown in Assam, India: A Comparative Study	15
Application of Artificial Intelligence-Based Approaches in the Discovery and Development of Protein Kinase Inhibitors (PKIs) Targeting Anticancer Activity	15
Multimodal Activity of a Novel Compound against Prostate and Pancreatic Cancer	15
Recent Applications of Bioinformatics in Target Identification and Drug Discovery for Alzheimer’s Disease	15
A Compressive Review on Source, Toxicity and Biological Activity of Flavonoid	15
Machine Learning and Artificial Intelligence: A Paradigm Shift in Big Data-Driven Drug Design and Discovery	14
A New Advanced Approach: Design and Screening of Affinity Peptide Ligands Using Computer Simulation Techniques	14
Importance of Indazole against Neurological Disorders	14
Phytotherapeutics in Cancer: From Potential Drug Candidates to Clinical Translation	14
Recent Advances in the Multistep Continuous Preparation of APIs and Fine Chemicals	14
A Comprehensive Review on Phytochemistry and Pharmacology ofRosaSpecies (Rosaceae)	14
Acknowledgement to Reviewers	13
A Comprehensive Review on the Antimicrobial Activity of the Genus Artemisia, Artemisinin, and its Derivatives	13
Therapeutics for the Management of Cytokine Release Syndrome in COVID-19	13
The Role of Cytokines in Activation of Tumour-promoting Pathways and Emergence of Cancer Drug Resistance	13
A Review of The Place of Adipose-Derived Stem Cells among Stem Cell Applications in Neurodegenerative Diseases	13
A Concise Review on the Role of Natural and Synthetically Derived Peptides in Colorectal Cancer	13
100 Years of Insulin: A Historical Perspective	13
Drug Repurposing Meets DNA Independent Pathways: Targeting Alternative Substrates for Anticancer Therapy	13
Identification and Verification of a Prognostic Risk Signature in Oral Squamous Cell Carcinoma	13
Selected Natural and Synthetic Agents Effective against Parkinson’s Disease with Diverse Mechanisms	13
Pharmacological and Therapeutic Potential of Berbamine: A Potent Alkaloid from Genus Berberis	12
Development and Exploration of Organic Compounds as Aldose Reductase Inhibitors: An Overview	12
Hybrid Compounds in Polypharmacology	12
A Comprehensive Review on Current Perspectives of Flavonoids as Antimicrobial Agent	12
Research Progress in Chemical Synthesis and Biosynthesis of Bioactive Pyridine Alkaloids	12
Medicinal Chemistry Advancement in Life-Threatening Diseases	11
The Current Landscape in the Development of Small-molecule Modulators Targeting Sphingosine-1-phosphate Receptors to Treat Neurodegenerative Diseases	11
Thermally-Induced Self-Agglomeration: Method and First Approaches to the Structural, Mechanical and Biological Characterization of Nanofiber Scaffolds	11
Decoding Dementia Mechanisms: Identification of Key Oligodendrocyte Associated Genes through Integrative Bioinformatics and MachineLearning	11
Antiviral Effects and Mechanisms of Green Tea Catechins on Influenza: A Perception on Combating Symptoms from COVID-19	11
Neuroprotective Role of Phytoconstituents-based Nanoemulsion for the Treatment of Alzheimer’s Disease	11
Physicochemical Significance of Topological Indices: Importance in Drug Discovery Research	11
Prodrug Strategies for Critical Drug Developability Issues: Part II	11
Impact of TRP Channels in Oral Pathology and Therapeutic Targeting Options: A Narrative Review	11
Reviewing the Synthesis and Clinical Application of FDA-approved Anticancer Medications	11
Molecular Modeling Techniques Applied to the Design of Multitarget Drugs: Methods and Applications	11
LINC-PINT: A Distinctive Long Non-Coding RNA Functioning as a Potential Suppressor in Tumorigenesis	11
Exploration of Computational Aids for Effective Drug Designing and Management of Viral Diseases: A Comprehensive Review	10
4-Nerolidylcatechol (4-NC) and Docetaxel Synergize in Controlling Androgen- independent Prostate Cancer Cells	10
Roles of C/EBPβ/AEP in Neurodegenerative Diseases	10
Psychedelics and Hallucinogens in Psychiatry: Finding New Pharmacological Targets	10
Coptis Chinensis Franch: Substance Basis, Mechanism of Action and Quality Control Standard Revealed Based on the Q-marker Concept and New Strategy of Systemic Pharmacology and Biosynthesis Rese	10
Multi-target Polypharmacology of 4-aminoquinoline Compounds against Malaria, Tuberculosis and Cancer	10
Naturally Occurring Steroidal Saponins as Potential Anticancer Agents: Current Developments and Mechanisms of Action	10
Adhesion Molecules as Prognostic Biomarkers in Coronary Artery Disease	10
Bioassay Guided Isolation and α-Glucosidase Inhibition Studies of a New Sesquiterpene from Ochradenus aucheri	10
Recent Advances in Drug Discovery for Parasitic Diseases	10
Non-vesicular Lipid Transport Machinery in Trichomonas vaginalis: Novel Drug Targets against Trichomoniasis	10
Aminoglycosides with Anti-MRSA Activity: A Concise Review	10
Review the Role of Metabolism Reprogramming in the Pathogenesis of Post-surgical Adhesion: A New Therapeutic Strategy	10
The Functional Mechanism and Structure-Activity Relationship of Antibacterial Peptides	10
Recent Strategies and Challenges in Immunity and Nanomaterials for Cancer Therapy	10
A Review of the Biological Activities of Heterocyclic Compounds Comprising Oxadiazole Moieties	10
An Overview on Antifilarial Efficacy of Heterocyclic Motifs Encompassing Synthetic Strategies, SAR and Commercialized Medications	10
Heterocyclic Phytochemicals as Anticancer Agents	10
Advances in Nanomaterial-based Biosensors for Determination of Glycated Hemoglobin	10
1,3,4-Thiadiazole as a Structural Motif: Advances in SAR, and Drug Discovery Applications	10
Neuroactive Phytoconstituents of Glycyrrhiza glabra for the Treatment of Alzheimer’s Disease	10
A Mini Review on Pharmacological Significance of Isatin-1,2,3-Triazole Hybrids	9
Neurobiology of Dream Activity and Effects of Stimulants on Dream	9
Green Synthetic and Pharmacological Developments in the Hybrid Quinazolinone Moiety: An Updated Review	9
The Design of Multi-target Drugs to Treat Cardiovascular Diseases: Two (or more) Birds on One Stone	9
Phytochemicals for Human Health: The Emerging Trends and Prospects, Part-2	9
Current Updates on Recent Developments in Artificial Intelligence in QSAR Modelling for Drug Discovery against Lung Cancer	9
A Comprehensive Review on the Application of Marketed Drugs as Ligands through Metallopharmaceutics	9
Flavonoid: A Natural Scaffold with Modulatory Activities on Diverse Cellular Signaling Pathways Related to Complex Diseases	9
Advances in the Study of Halogenated Natural Products	9
Thiazolidine Derivatives: An Up-to-Date Review of Synthesis and Biological Activity	9
Antiproliferative Activity and Mechanisms of Action of Plant-derived Flavonoids on Breast Cancer	9
Benzothiazole as a Promising Scaffold for the Development of Antifungal Agents	9
Noncoding RNAs in Alzheimer’s Disease: Overview of Functional and Therapeutic Significance	9

Discovery of Diphenylsilane Compounds as Potential Inhibitors ofZn-Metalloproteinase Thermolysin Using Artificial Neural Networks	9
Ziziphi Spinosae Semen: A Natural Herb Resource for Treating Neurological Disorders	9
Employing “Red Flags” to Fight the Most Neglected Diseases: Nitroaromatic as Still Suitable Tools to Treat Human and Veterinary Parasitosis	9
Molecular Characterization of Primary and Metastatic Colon Cancer Cells to Identify Therapeutic Targets with Natural Compounds	9
Use of Immunoglobulin Y Antibodies: Biosensor-based Diagnostic Systems and Prophylactic and Therapeutic Drug Delivery Systems for Viral Respiratory Diseases	9
In Silico and In Vivo Hepatorenal Protective Effect of Chitosan-Loaded Chrysin Nanoparticles in Obese Rats	9
HDAC Inhibition as Neuroprotection in COVID-19 Infection	9
Navigating the Alzheimer's Treatment Landscape: Unraveling Amyloid-beta Complexities and Pioneering Precision Medicine Approaches	9
Biofunctionalized Nano-antimicrobials - Progress, Prospects and Challenges	8
Unveiling Anti-Cancer Potential through ADMET Prediction, MolecularDocking, Molecular Dynamics, and In vitro Analysis: Approach toEstablish Alpha-Terpineol as a Potential Drug Candidate against Glioma	8
Recent Efforts in the Discovery of Urease Inhibitor Identifications	8
A Review on Aptamers Selection and Application in Heart Diseases Diagnosis	8
Mining of Targeted Therapeutic Drugs for Hepatocellular Carcinoma based on Programmed Cell Death-related Features and Construction of an Imaging Histology Diagnostic Model	8
A Review of Computational Approaches Targeting SARS-CoV-2 Main Protease to the Discovery of New Potential Antiviral Compounds	8
FDA-Approved Fluorine-Containing Molecules in 2024: Significance, Synthesis, and Therapeutic Applications	8
A Comprehensive Review of Pharmacokinetics and Pharmacodynamics in Animals: Exploration of Interaction with Antibiotics of Shuang-Huang- Lian Preparations	8
Hybrid Molecules with Potential Activity Against Methicillin-resistance Staphylococcus aureus Part I	8
Probing the Interaction of Selonsertib with Human Serum Albumin: In silico and In vitro Approaches	8
An Updated Overview of Synthetic α-glucosidase Inhibitors: Chemistry and Bioactivities	8
Stimuli-sensitive Chitosan-based Nanosystems-immobilized Nucleic Acids for Gene Therapy in Breast Cancer and Hepatocellular Carcinoma	8
A Comprehensive Review of mRNA-based Vaccines for COVID-19, A New Era in Pharmaceuticals: Unspecified and Unknown Aspects, Effects and Challenges	8
Quantitative Structure Activity/Toxicity Relationship through Neural Networks for Drug Discovery or Regulatory Use	8
Targeting c-Met in Cancer Therapy: Unravelling Structure-activity Relationships and Docking Insights for Enhanced Anticancer Drug Design	8
Recent Development of Heterocyclic Compounds with Indazole Moiety as Potential Antiparasitic Agents	8
Harnessing the Therapeutic Potential of Antimicrobial Peptides for Cancers: State of the Art	8
Synthesis, X-Ray Structure, Characterization, Antifungal Activity, DFT, and Molecular Simulation of a Novel Pyrazole Carboxylic Acid	8
Nanomaterial-based Electrochemical Sensors for Multiplex Medicinal Applications	8
Oxyprenylated Secondary Metabolites as Modulators of Lipid and Sugar Metabolism	8
The Vital Role of Long Non-Coding RNA SUMO1P3 in the Regulation of Human Cancer: Current Perspectives and Future Challenges	7
Zingerone Induces Apoptosis and Ferroptosis in Prostate Cancer DU145 Cells	7
Recent Advances in the Development of Nitrogen-containing Heterocyclic Anti-alzheimer’s Agents	7
The Impact and Role of Artificial Intelligence (AI) in Healthcare: Systematic Review	7
Recent Advances in Nanocatalyzed One-Pot Sustainable Synthesis of Bioactive N, N-Heterocycles with Anticancer Activities: An Outlook of Medicinal Chemistry	7
Pharmacodynamic Interactions: Mechanisms, Clinical Trial Insights, and Patent Perspectives	7
The Computational Tools to Identify DNA Repeats and Motifs: A Systematic Review	7
Non-fused Pyrimidine Derivatives as Potential Pharmacological Entities: A Review	7
5-Membered Heterocyclic Compounds as Antiviral Agents	7
Synthesis and In vitro and In silico Anti-inflammatory Activity of New Thiazolidinedione-quinoline Derivatives	7
Pharmacological Chemistry and Biomedical Implications of Chemical Ingredients from Parthenium hysterophorus	7
Viral Vertical Transmission through the Placenta: The Potential ofNatural Products as Therapeutic and Prophylactic Antiviral Agents	7
Nano-cocrystals as Nanotechnology-based Approach to Modulate Solubility and Bioavailability of Poorly Soluble Drugs	7
Therapeutic Potential of Quercetin in Diabetic Neuropathy and Retinopathy: Exploring Molecular Mechanisms	7
Advancements and Scientific Partnerships in the Application of Polysaccharides in Oral Formulations: A Bibliometric Analysis and Review	7
Natural Products as Sources of Multitarget Compounds: Advances in the Development of Ferulic Acid as Multitarget Therapeutic	7
Natural-Derived Products and Nanomaterials for the Treatment of Cancer and Chronic Disorders (Part 1)	7
Electrochemical Protein-based Bioanalytical Devices for Drug Analysis	7
Ethnobotanical Study of Knowledge and Herbal Recipes of Medicinal Plants in Ancient Izki, Al Dakhliya Region, Sultanate of Oman	7
Recent Advances in Di-, Tri-Substituted Mono-Thiazoles, and Bis-Thiazoles: Factors Affecting Biological Activities, Future Aspects, and Challenges	7
Transforming Breast Cancer Therapy: The Pivotal Role of Nanoparticles	7
Recent Advances in Chemical Composition and Transdermal Delivery Systems for Topical Bio-actives in Skin Cancer	7
Exploring the Structure-Activity Relationship of COX Inhibitors with Anticancer Effects: A Comprehensive Review	7
Targeting Various Pathogenic Pathways for the Development of Anti-alzheimer’s Drugs: An Update	7
Mechanisms of Metallic Nanomaterials to Induce an Antibacterial Effect	7
Melanin Synthesized by the Endophytic Aureobasidium Pullulans AKW: A Multifaceted Biomolecule with Antioxidant, Wound Healing, and Selective Anti-Cancer Activity	7
Coumarin as a Privileged and Medicinally Important Scaffold in the Treatment of Tuberculosis	7
SRT1720 Treatments Hepatic Ischemia Reperfusion Injury by Regulation of NF-κB Signaling Pathways and Reduce Cell Apoptosis: From Network Pharmacology to Experimental Validation	7
Clinical Research Progress of BTK Inhibitors in the Treatment of Autoimmune Diseases	7
Ameliorative Effects of Essential Oils on Diabetes Mellitus: A Review	7