Current Topics in Medicinal Chemistry

Article	Citations
Review on Epidermal Growth Factor Receptor (EGFR) Structure, Signaling Pathways, Interactions, and Recent Updates of EGFR Inhibitors	237
Bioactive Compounds Effective Against Type 2 Diabetes Mellitus: A Systematic Review	80
Akt Pathway Inhibitors	57
Role of Flavonoids in Neurodegenerative Diseases: Limitations and Future Perspectives	48
Biological Signatures of Alzheimer’s Disease	47
Emerging Proof of Protein Misfolding and Interactions in Multifactorial Alzheimer's Disease	41
A Review on Natural Sources Derived Protein Nanoparticles as Anticancer Agents	40
Indole Alkaloids with Potential Anticancer Activity	38
Recent Progress in 1H-1,2,3-triazoles as Potential Antifungal Agents	37
Targeting Tau Hyperphosphorylation via Kinase Inhibition: Strategy to Address Alzheimer's Disease	36
Recent Development of 1,2,4-triazole-containing Compounds as Anticancer Agents	33
The Effect of Recombinant Human Interferon Alpha Nasal Drops to Prevent COVID-19 Pneumonia for Medical Staff in an Epidemic Area	32
Novel Drugs Targeting the SARS-CoV-2/COVID-19 Machinery	32
An Update on Staphylococcus aureus NorA Efflux Pump Inhibitors	32
Coumarin-1,2,3-triazole Hybrid Molecules: An Emerging Scaffold for Combating Drug Resistance	32
1,2,4-Triazole: A Privileged Scaffold for the Development of Potent Antifungal Agents - A Brief Review	31
Nanotechnology, A Tool for Diagnostics and Treatment of Cancer	29
Glycogen Synthase Kinase 3 (GSK3): Its Role and Inhibitors	29
An Overview of Privileged Scaffold: Quinolines and Isoquinolines in Medicinal Chemistry as Anticancer Agents	29
An Updated Review on SARS-CoV-2 Main Proteinase (MPro): Protein Structure and Small-Molecule Inhibitors	28
Nociceptin/Orphanin FQ Peptide Receptor-Related Ligands as Novel Analgesics	27
Shape-based Machine Learning Models for the Potential Novel COVID-19 Protease Inhibitors Assisted by Molecular Dynamics Simulation	27
Healthy Gut, Healthy Brain: The Gut Microbiome in Neurodegenerative Disorders	26
Fungal Infections in COVID-19-Positive Patients: A Lack of Optimal Treatment Options	26
Peptide Receptor Radionuclide Therapy: Looking Back, Looking Forward	26

Rosmarinic Acid as a Potent Influenza Neuraminidase Inhibitor: In Vitro and In Silico Study	25
The Antibacterial Activity of 1,2,3-triazole- and 1,2,4-Triazole-containing Hybrids against Staphylococcus aureus: An Updated Review (2020- Present)	25
Eugenol as a Potential Drug Candidate: A Review	25
Potential Inhibitors of Protein Tyrosine Phosphatase (PTP1B) Enzyme: Promising Target for Type-II Diabetes Mellitus	25
Preclinical and Clinical Studies on Bryostatins, A Class of Marine-Derived Protein Kinase C Modulators: A Mini-Review	25
Cruzain and Rhodesain Inhibitors: Last Decade of Advances in Seeking for New Compounds Against American and African Trypanosomiases	24
Berberine: A Promising Natural Isoquinoline Alkaloid for the Development of Hypolipidemic Drugs	24
Docking Paradigm in Drug Design	23
Synergism between Host Defence Peptides and Antibiotics Against Bacterial Infections	23
1,3,5-Triazine-azole Hybrids and their Anticancer Activity	22
Natural Products as Sources of Multitarget Compounds: Advances in the Development of Ferulic Acid as Multitarget Therapeutic	22
Isoform-Selective PI3K Inhibitors for Various Diseases	21
Emerging Promise of Immunotherapy for Alzheimer’s Disease: A New Hope for the Development of Alzheimer’s Vaccine	21
Construction of a Neuro-Immune-Cognitive Pathway-Phenotype Underpinning the Phenome of Deficit Schizophrenia	21
Chemical and Biological Evaluation of Thiosemicarbazone-Bearing Heterocyclic Metal Complexes	21
Garlic (Allium sativum L.): Its Chemistry, Nutritional Composition, Toxicity, and Anticancer Properties	21
Small Molecule CDK Inhibitors for the Therapeutic Management of Cancer	21
A Multi-layered Variable Selection Strategy for QSAR Modeling of Butyrylcholinesterase Inhibitors	20
“Big Three” Infectious Diseases: Tuberculosis, Malaria and HIV/AIDS	20
Moxifloxacin-isatin Hybrids Tethered by 1,2,3-triazole and their Anticancer Activities	20
The Antibacterial Activity of Natural-derived Flavonoids	20
Resveratrol in Cancer Therapy: From Stimulation of Genomic Stability to Adjuvant Cancer Therapy: A Comprehensive Review	19
Resveratrol and Colorectal Cancer: A Molecular Approach to Clinical Researches	18
PTML Modeling for Alzheimer’s Disease: Design and Prediction of Virtual Multi-Target Inhibitors of GSK3B, HDAC1, and HDAC6	18
Exploring the Potential Inhibition of Candidate Drug Molecules for Clinical Investigation Based on their Docking or Crystallographic Analyses against M. tuberculosis Enzyme Targets	18
Recent Efforts in the Discovery of Urease Inhibitor Identifications	18
Quinoline-based Compounds with Potential Activity against Drugresistant Cancers	18
Investigation of the Relationship among Cortisol, Pro-inflammatory Cytokines, and the Degradation of Tryptophan into Kynurenine in Patients with Major Depression and Suicidal Behavior	18
Evidence Linking Protein Misfolding to Quality Control in Progressive Neurodegenerative Diseases	18
Trends of Pharmaceutical Design of Endophytes as Anti-infective	18
The Tryptophan Catabolite or Kynurenine Pathway’s Role in Major Depression	18
Interleukin-1 in Coronary Artery Disease	18
Indole Alkaloids, Synthetic Dimers and Hybrids with Potential In Vivo Anticancer Activity	18
Bergenin - A Biologically Active Scaffold: Nanotechnological Perspectives	17
Recent Advances of α-Glucosidase Inhibitors: A Comprehensive Review	17
Current Scenario of 1,3-oxazole Derivatives for Anticancer Activity	17
Thiazole-based Chalcone Derivatives as Potential Anti-inflammatory Agents: Biological Evaluation and Molecular Modelling	17
Computational and Experimental Approaches to Investigate Lipid Nanoparticles as Drug and Gene Delivery Systems	17
New Pharmacological Targets for the Treatment of Schizophrenia: A Literature Review	16
Self-Assembling, Ultrashort Peptide Gels as Antimicrobial Biomaterials	16
Tuberculosis: An Update on Pathophysiology, Molecular Mechanisms of Drug Resistance, Newer Anti-TB Drugs, Treatment Regimens and Host- Directed Therapies	16
Research Progress in Flavonoids as Potential Anticancer Drug Including Synergy with Other Approaches	16
Potential Therapeutic Strategies of Phytochemicals in Neurodegenerative Disorders	15
Therapeutic Targets and Computational Approaches on Drug Development for COVID-19	15
Experimental and Computational Approaches to Improve Binding Affinity in Chemical Biology and Drug Discovery	15
Tumor-associated Macrophages (TAMs) in Cancer Resistance; Modulation by Natural Products	15
An Overview of Ovarian Cancer: Molecular Processes Involved and Development of Target-based Chemotherapeutics	15
1,3,4-thiadiazole: A Privileged Scaffold for Drug Design and Development	14
Chalcone Derivatives and their Activities against Drug-resistant Cancers: An Overview	14
Traditional Uses, Pharmacological, and Phytochemical Studies of Euphorbia: A Review	14

The Anticancer Activity of Indazole Compounds: A Mini Review	14
Computer-Aided Drug Design Applied to Secondary Metabolites as Anticancer Agents	14
Interaction of Platinum-based Drugs with Proteins: An Overview of Representative Crystallographic Studies	14
Relevance of Aromatase Inhibitors in Breast Cancer Treatment	14
Multi-target Drug Discovery via PTML Modeling: Applications to the Design of Virtual Dual Inhibitors of CDK4 and HER2	14
Recent Developments of Flavonoids with Various Activities	14
Perspectives on Fragment-based Drug Discovery: A Strategy Applicable to Diverse Targets	14
Natural Bioactive as a Potential Therapeutic Approach for the Management of Cyclophosphamide-induced Cardiotoxicity	14
Nanoscale Drug Delivery Systems for Glaucoma: Experimental and In Silico Advances	13
Host Defence Cryptides from Human Apolipoproteins: Applications in Medicinal Chemistry	13
Decoding Protein-protein Interactions: An Overview	13
Recent Advances in β-lactam Derivatives as Potential Anticancer Agents	13
Breast Cancer Transcriptional Regulatory Network Reprogramming by using the CRISPR/Cas9 System: An Oncogenetics Perspective	13
An Updated Review on Betacoronavirus Viral Entry Inhibitors: Learning from Past Discoveries to Advance COVID-19 Drug Discovery	13
Recent Trends in Drug Design and Discovery	13
The Anti-Breast Cancer Potential of Bis-Isatin Scaffolds	13
Nanomedicine and Early Cancer Diagnosis: Molecular Imaging using Fluorescence Nanoparticles	13
The Effects on Angiogenesis of Relevant Inorganic Chemotherapeutics	13
Membrane Derived Vesicles as Biomimetic Carriers for Targeted Drug Delivery System	13
Hyaluronan-based Multifunctional Nano-carriers for Combination Cancer Therapy	13
Therapeutic Potential of Indole Derivatives as Anti-HIV Agents: A Mini-review	13
Stem Cell Therapy in Combination with Naturopathy: Current Progressive Management of Diabetes and Associated Complications	12
A Comprehensive Review on the Medicinal Importance; Biological and Therapeutic Efficacy of Lagenaria siceraria (Mol.) (Bottle Gourd) Standley Fruit	12
Electrochemical Cell-based Biosensors for Biomedical Applications	12
A Mini Review on Pharmacological Significance of Isatin-1,2,3-Triazole Hybrids	12
Exploring the Potential of Neuroproteomics in Alzheimer's Disease	12
Structure and Functions of Bacterial Outer Membrane Protein A, A Potential Therapeutic Target for Bacterial Infection	12
Ligand and Structure-based Virtual Screening of Lamiaceae Diterpenes with Potential Activity against a Novel Coronavirus (2019-nCoV)	12
Coumarins as Potential Anti-drug Resistant Cancer Agents: A Mini Review	12
Computer-Aided Structure Prediction of Bluetongue Virus Coat Protein VP2 Assisted by Optimized Potential for Liquid Simulations (OPLS)	12
Recent Developments of Coumarin-based Hybrids in Drug Discovery	12
A Comprehensive Review on Current Perspectives of Flavonoids as Antimicrobial Agent	12
Plant-food-derived Bioactives in Managing Hypertension: From Current Findings to Upcoming Effective Pharmacotherapies	12
Roles of Medicinal Plants and Constituents in Gynecological Cancer Therapy: Current Literature and Future Directions	12
Current Status of Novel Pyridine Fused Derivatives as Anticancer Agents: An Insight into Future Perspectives and Structure Activity Relationship (SAR)	12
Natural and Synthetic Naphthoquinones as Potential Anti-Infective Agents	11
The Role of Peroxisome Proliferator-Activated Receptor in Addiction: A Novel Drug Target	11
Juglone: A Versatile Natural Platform for Obtaining New Bioactive Compounds	11
Periodontal Pathogens and Neuropsychiatric Health	11
Role of Phytomolecules in the Treatment of Obesity: Targets, Mechanisms and Limitations	11
Ziziphi Spinosae Semen: A Natural Herb Resource for Treating Neurological Disorders	11
Learning the Edit Costs of Graph Edit Distance Applied to Ligand-Based Virtual Screening	11
The Recent Development of Tetrahydro-Quinoline/Isoquinoline Based Compounds as Anticancer Agents	11
Phenolic Acids - Versatile Natural Moiety with Numerous Biological Applications	11
Antibacterial Assessment of Zinc Sulfide Nanoparticles againstStreptococcus pyogenesandAcinetobacter baumannii	11
Plant Extracts and their Secondary Metabolites as Modulators of Kinases	11
Advances in Computational Methods to Discover New NS2B-NS3 Inhibitors Useful Against Dengue and Zika Viruses	10
Advances in the Design and Development of PROTAC-mediated HDAC Degradation	10
The Reification of the Clinical Diagnosis of Myalgic Encephalomyelitis/ Chronic Fatigue Syndrome (ME/CFS) as an Immune and Oxidative Stress Disorder: Construction of a Data-driven Nomothethic Network	10
Recent Studies on Design and Development of Drugs Against Alzheimer’s Disease (AD) Based on Inhibition of BACE-1 and Other AD-causative Agents	10
MiR-509-3-5p-NONHSAT112228.2 Axis Regulates p21 and Suppresses Proliferation and Migration of Lung Cancer Cells	10
The G Protein Signal-Biased Compound TRV130; Structures, Its Site of Action and Clinical Studies	10
Euglena Species: Bioactive Compounds and their Varied Applications	10
Recent Advances in the Development of 1,2,3-Triazole-containing Derivatives as Potential Antifungal Agents and Inhibitors of Lanoster ol 14α-Demethylase	10
Role of Extracellular Vesicles in Glioma Progression: Deciphering Cellular Biological Processes to Clinical Applications	10
Predicting Metabolic Reaction Networks with Perturbation-Theory Machine Learning (PTML) Models	10
Advances in Studies on Stroke-Induced Secondary Neurodegeneration (SND) and Its Treatment	10
Antidiabetic Potential of Naturally Occurring Sesquiterpenes: A Review	10
Recent Updates on Pyrazoline Derivatives as Promising Candidates for Neuropsychiatric and Neurodegenerative Disorders	10
Chimeric Virus-like Particles of Universal Antigen Epitopes of Coronavirus and Phage Qβ Coat Protein Trigger the Production of Neutralizing Antibodies	10
GPRASP/ARMCX Protein Family: Potential Involvement in Health and Diseases Revealed by their Novel Interacting Partners	10
Organic Polymer and Metal Nano-particle Based Composites for Improvement of the Analytical Performance of Electrochemical Biosensors	10
Therapeutic Potential of Naturally Occurring Benzofuran Derivatives and Hybrids of Benzofurans with other Pharmacophores as Antibacterial Agents	9
Nanophytomedicine Based Novel Therapeutic Strategies in Liver Cancer	9
Nutraceuticals and Bio-inspired Materials from Microalgae and their Future Perspectives	9
Flavonoids as Sirtuin Modulators	9
Coronavirus Disease (COVID-19) Pandemic: A Race Against Time	9
Novel Iodinated Hydrazide-hydrazones and their Analogues as Acetyl- and Butyrylcholinesterase Inhibitors	9
1,2,3-Triazole Derivatives with Anti-breast Cancer Potential	9
Advancement of Prodrug Approaches for Nucleotide Antiviral Agents	9
Cedrus deodara (Bark) Essential Oil Induces Apoptosis in Human Colon Cancer Cells by Inhibiting Nuclear Factor kappa B	9
Phytochemicals-based Therapeutics against Alzheimer's Disease: An Update	9
Imidazole Scaffold Based Compounds in the Development of Therapeutic Drugs	9
Promising Essential Oils/Plant Extracts in the Prevention and Treatment of Dandruff Pathogenesis	9
Pyrimidine-fused Dinitrogenous Penta-heterocycles as a Privileged Scaffold for Anti-Cancer Drug Discovery	9
Drug-lead Anti-tuberculosis Phytochemicals: A Systematic Review	9
A Medicinal Chemist’s Perspective Towards Structure Activity Relationship of Heterocycle Based Anticancer Agents	9
Wnt/β-catenin Signaling Inhibitors	9
Glycyrrhetinic Acid and TAT Peptide Modified Dual-functional Liposomes for Treatment of Hepatocellular Cancer	9
Anti-breast Cancer Potential of Natural and Synthetic Coumarin Derivatives	9

Detection of Natural Inhibitors against Human Liver Cancer Cell Lines through QSAR, Molecular Docking and ADMET Studies	9
Application of Polymeric Nano-Materials in Management of Inflammatory Bowel Disease	9
Potential Therapeutic Relevance of CRISPR/Cas9 Guided Epigenetic Regulations for Neuropsychiatric Disorders	9
Efficiency of Homology Modeling Assisted Molecular Docking in G-protein Coupled Receptors	8
Epidermal Growth Factor Receptor and its Trafficking Regulation by Acetylation: Implication in Resistance and Exploring the Newer Therapeutic Avenues in Cancer	8
Developing a Multi-target Model to Predict the Activity of Monoamine Oxidase A and B Drugs	8
Unleashing the Potential of Microbial Natural Products in Drug Discovery: Focusing on Streptomyces as Antimicrobials Goldmine	8
Machine Learning and Artificial Intelligence: A Paradigm Shift in Big Data-Driven Drug Design and Discovery	8
Phosphodiesterase as a Target for Cognition Enhancement in Schizophrenia	8
OMICs Technologies for Natural Compounds-based Drug Development	8
Host Cell Proteases Mediating SARS-CoV-2 Entry: An Overview	8
COVID-19: Small-Molecule Clinical Trials Landscape	8
PTML Multi-Label Algorithms: Models, Software, and Applications	8
1,3,4-Oxadiazoles as Potential Pharmacophore for Cytotoxic Potentiality: A Comprehensive Review	8
4-Aryl-1,4-Dihydropyridines as Potential Enoyl-Acyl Carrier Protein Reductase Inhibitors: Antitubercular Activity and Molecular Docking Study	8
Recent Advances in the Application of Podophyllotoxin Derivatives to Fight Against Multidrug-Resistant Cancer Cells	8
MicroRNAs as Potential Biomarkers in Coronary Artery Disease	8
2,4,5-Trisubstituted Thiazole: A Privileged Scaffold in Drug Design and Activity Improvement	8
Nitrogen-containing Heterocycle: A Privileged Scaffold for Marketed Drugs	8
Vascular Endothelial Growth Factor Receptors [VEGFR] as Target in Breast Cancer Treatment: Current Status in Preclinical and Clinical Studies and Future Directions	8
Natural Flavonoids as Potential Therapeutics in the Management of Diabetic Wound: A Review	8
An Emerging Therapeutic Approach by Targeting Myoferlin (MYOF) for Malignant Tumors	8
High-resolution MD Simulation Studies to Get Mechanistic Insights into the Urea-induced Denaturation of Human Sphingosine Kinase 1	8
The Antibacterial Activity of Isatin Hybrids	8
Interactions between Personality, Depression, Anxiety and Cognition to Understand Early Stage of Alzheimer’s Disease	8
Production of Effective Phyto-antimicrobials via Metabolic Engineering Strategies	8
Carbon Monoxide as a Therapeutic for Airway Diseases: Contrast and Comparison of Various CO Delivery Modalities	8
Exploring Multiple Sclerosis (MS) and Amyotrophic Lateral Scler osis (ALS) as Neurodegenerative Diseases and their Treatments: A Review Study	8
Solubility Enhancement of Methotrexate by Solid Nanodispersion Approach for the Improved Treatment of Small Cell Lung Carcinoma	8
Amino Acid Derived Prodrugs: An Approach to Improve the Bioavailability of Clinically Approved Drugs	8
A Natural Membrane Vesicle Exosome-based Sinomenine Delivery Platform for Hepatic Carcinoma Therapy	8
A Quinquennial Review on Recent Advancements and Developments in Search of Anti-malarial Agents	8
Importance of Indazole against Neurological Disorders	8
Most Promising Compounds for Treating COVID-19 and Recent Trends in Antimicrobial & Antifungal Agents	8
On the Possible Relevance of Bottom-up Pathways in the Pathogenesis of Alzheimer’s Disease	8
Current Advances and Limitations of Deep Learning in Anticancer Drug Sensitivity Prediction	8
The Antibacterial Activity of Quinazoline and Quinazolinone Hybrids	7
Opuntia ficus indica (L.) Mill. An Ancient Plant Source of Nutraceuticals	7
In vivo Anticancer Potential of Hydroxamic Acid Derivatives	7
Insights into Nanotherapeutic Strategies as an Impending Approach to Liver Cancer Treatment	7
The Hybrid Compounds as Multi-target Ligands for the Treatment of Alzheimer's Disease: Considerations on Donepezil	7
Recent Progress in Oleanolic Acid: Structural Modification and Biological Activity	7
Spotlight on the Selected New Antimicrobial Innate Immune Peptides Discovered During 2015-2019	7
Recent Advancements in Macrolide Hybrids against Staphylococcus aureus	7
Recent Development in Fluorescent Probes for Copper Ion Detection	7
Epidemiological Features of the 2019 Novel Coronavirus Outbreak in China	7
The Role of Flavonoids in Inhibiting IL-6 and Inflammatory Arthritis	7
A Review of the Biological Activities of Heterocyclic Compounds Comprising Oxadiazole Moieties	7
Multi-target Polypharmacology of 4-aminoquinoline Compounds against Malaria, Tuberculosis and Cancer	7
Key Advances in MIP-based Sensors Applied for Cancer and Cardiovascular Biomarkers Detection	7
Targeting Tumor Immunosuppressive Microenvironment for the Prevention of Hepatic Cancer: Applications of Traditional Chinese Medicines in Targeted Delivery	7
Hepatocellular Carcinoma Targeting and Pharmacodynamics of Paclitaxel Nanoliposomes Modified by Glycyrrhetinic Acid and Ferric Tetroxide	7
In-silico Studies and Wet-Lab Validation of Camptothecin Derivatives for Anti-Cancer Activity Against Liver (HepG2) and Lung (A549) Cancer Cell Lines	7
Bis-triazole-containing Compounds with Anticancer Potential: A Short Review	7
ENTPDases from Pathogenic Trypanosomatids and Purinergic Signaling: Shedding Light towards Biotechnological Applications	7
Discussion on the Structural Modification and Anti-tumor Activity of Flavonoids	7
Organic Antifungal Drugs and Targets of Their Action	7
Antiangiogenic Therapy: Challenges and Future Directions	7
Advances in Nanomaterial-based Biosensors for Determination of Glycated Hemoglobin	7
A Multi-target Drug Designing for BTK, MMP9, Proteasome and TAK1 for the Clinical Treatment of Mantle Cell Lymphoma	7
Differences in Kynurenine Metabolism During Depressive, Manic, and Euthymic Phases of Bipolar Affective Disorder	7
Nanotechnology Assisted Chemotherapy for Targeted Cancer Treatment: Recent Advances and Clinical Perspectives	7
The Potential of Secondary Metabolites from Plants as Drugs or Leads against Trypanosoma cruzi-An Update from 2012 to 2021	7
Synthesis and Evaluation of Antimicrobial Activity and Molecular Docking of New N-1,3-thiazol-2-ylacetamides of Condensed Pyrido[3',2':4,5] furo(thieno)[3,2-d]pyrimidines	7
Application of a Novel Metallomics Tool to Probe the Fate of Metal-Based Anticancer Drugs in Blood Plasma: Potential, Challenges and Prospects	7
Bioinformatics Paradigms in Drug Discovery and Drug Development	7
Xanthones: A Class of Heterocyclic Compounds with Anticancer Potential	7
Impact of Indazole Scaffold as Antibacterial and Antifungal Agent	7
Cellular Bioenergetic and Metabolic Changes in Patients with Autism Spectrum Disorder	7