Current Topics in Medicinal Chemistry

Article	Citations
The Role of Herbal Medicine in Modulating Bone Homeostasis	57
Privileged Scaffold for Drug Design and Activity Improvement - Part IV	54
Recent Developments in the Therapeutics for Endocrine Diseases	53
Recent Advances in the Use of Multitarget Therapeutics	49
Qi Yin San Liang San Decoction Relieves Gefitinib-Induced Diarrhea via the Modulation of Chemokines and Innate Immune Responses	47
Discovery of MMP1 Inhibitors from Dandelion using Molecular Simulation and Bioactivity Test	45
Valeriana jatamansi: Bioactive Compounds and their Medicinal Uses	43
Computer-aided Drug Discovery of Epigenetic Modulators in Dual-target Therapy of Multifactorial Diseases	43
Eco-friendly Approaches to Chromene Derivatives: A Comprehensive Review of Green Synthesis Strategies	43
Next-generation Bruton’s Tyrosine Kinase (BTK) Inhibitors Potentially Targeting BTK C481S Mutation- Recent Developments and Perspectives	36
Tackling Nontuberculous Mycobacteria by Repurposable Drugs and Potential Leads from Natural Products	34
Ethyl Acetate Extract from Wenxia Formula (WFEA) Attenuates Immunosuppression in Lung Cancer by Inhibiting Treg Differentiation via Blockade of TGF-Β/Smad Signaling	34
Application of Virtual Sample Generation and Screening in Process Parameter Optimization of Botanical Medicinal Materials	32
Green Synthesis of Biorelevant Scaffolds through Organocatalytic/ Enzymatic Dynamic Kinetic Resolution	32
Synthesis of Isatin-derived Heterocycles with Promising Anticancer Activities	31
From Nature to Drug: Overview and CADD Approach of Anacardic Acidto Propose their Biological Potential	31
Fighting Antimicrobial Resistance with Natural Products - Current Developments and Future Prospects	31
The Gut Microbiota-Brain Axis: Potential Mechanism of Drug Addiction	31
Optimization, Preparation, and Cytotoxic Potential of Pyrus communisExtract Loaded Ethosomes on Skin Cancer Cell Lines	30
Modern Approaches to Diabetes: The Role of Phytochemicals inTargeting Molecular Receptors	30
Bioanalysis, Analysis, Chemistry, and Pharmacological Aspects of Hypoxia-Inducible Factor Prolyl Hydroxylase Inhibitors	29
Natural Multi-targets: Advances and Applications	29
The Multitarget Action of Vitamins in the Ischemic Stroke	28
Current Organoid Culture Systems in Pancreatic Cancer	27
Recent Advances in the Design and Synthesis of Small Molecule Carbonic Anhydrase IX Inhibitors	26

Probing into the Flap-dimer Dynamics of the Mycobacterium tuberculosis Kasa Enzyme Binding Landscape Provides the Underlying Inhibitory Mechanisms of JSF-3285 and 5G	26
Effect of Withaferin-A, Withanone, and Caffeic Acid Phenethyl Ester on DNA Methyltransferases: Potential in Epigenetic Cancer Therapy	26
Hydrogen-producing Photocatalyst at Sunscreen for Athletes in Preventing and Healing Muscle-nerve-skin Injuries	26
Insight into the Recent Developments of Nanoparticles in Treatment of Cancer and Neuro-Degenerative Disease: A Review	25
Cinchonine: A Versatile Pharmacological Agent Derived from Natural Cinchona Alkaloids	25
Unlocking the Multifunctional Therapeutic Potential of Manassantin: A Lignan-Derived Scaffold	25
Wnt/β-catenin Signaling Inhibitors	25
Nutritional Value, Therapeutic Effects, Phytochemistry, and Toxicology of Lepisanthes fruticosa: A Review	25
Recent Advances in Metallic Nanostructures-assisted Biosensors for Medical Diagnosis and Therapy	25
Repurposing some of the Well-known Non-steroid Anti-inflammatory Drugs (NSAIDs) for Cancer Treatment	25
Finding Integrative Medication for Neuroblastoma and Glioblastoma through Zebrafish as A Model of Organism	23
Epigenetics Mechanism and Therapeutic Potential of Approved Epi-drugs in Pulmonary Hypertension Disease	23
Novel Biomarkers in Cardiovascular Diseases: Going beyond Troponins and Natriuretic Peptides - Part 1	23
Artificial Intelligence and Cheminformatics-Guided Modern Privileged Scaffold Research	23
Novel Therapeutic Strategies for the Management of Neuropathology and Neuroprotection in COVID-19	23
Drug Delivery Systems for Natural Medicines in Cancer Therapy	23
Exploring New Vista for Alzheimer's Disease Drug Targets	23
Acknowledgements to Reviewers	22
Role of Plant Materials with Anti-inflammatory Effects in Phytotherapy of Osteoarthritis	21
Conformation Study and Design of Novel 6-Hydroxybenzothiazole-2- Carboxamides as Potentially Potent and Selective Monoamine Oxidase B Inhibitors for Neuroprotection	21
Synthesis of Biorelevant Scaffolds under Greener Conditions (Part: 2)	21
Medicinal Chemistry and Target Identification of Synthetic Clinical and Advanced Preclinical Antimalarial Candidates (2000 - 2022)	21
Precision Psychiatry: Machine Learning as a Tool to Find New Pharmacological Targets	20
QSAR into the New Millennium: Structural, Topological, Quantum, Shape, Electronic and Bio Descriptors for Machine Learning & AI - Honoring Prof. Satya Prakash Gupta	20
Various Effects of the GABAergic System on Cancer: The Conditions and Specificities of its use in the Treatment of Some Cancers	20
Rheumatoid Arthritis: Pathogenesis, Therapeutic Strategies, Advances, and Structural Activity Relationships of Synthesized Agents	19
Review on the Developments of Benzothiazole-containing Antimicrobial Agents	19
Biosensors in Diagnostics and Medicinal Applications Part (II)	19
Effects of Flavonoids in Experimental Models of Arterial Hypertension	19
Highlighting the Therapeutic Potential of an Underexplored Target: Human Dihydroorotate Dehydrogenase in Cancer, Rheumatoid Arthritisand Sclerosis	19
Chemical Composition, Acetylcholine Esterase and Anti-bacterial Activities of Essential Oils of Elaeosilenum thapsioides (Desf.) Maire from Algeria	19
Oxidative Stress Biomarkers in Coronary Artery Disease	19
Progress in Synthesis and Therapeutic Applications of Mefloquine: A Review	19
Calotropis procera (Aiton) Dryand (Apocynaceae): State of the art of its uses and Applications	18
Plant-food-derived Bioactives in Managing Hypertension: From Current Findings to Upcoming Effective Pharmacotherapies	18
To Investigate Growth Factor Receptor Targets and Generate Cancer Targeting Inhibitors	18
Recent Biochemical Advances in Antitubercular Drugs: Challenges and Future	18
The Nitrite-Amines Nexus in Nitrosamine Formation: Mechanisms, Mutagenic Implications, Regulations, and Root Causes in Medicines	18
Insight into Tumor Hypoxia: Radionuclide-based Biomarker as Diagnostic Tools	18
Phytotherapeutics in Cancer: From Potential Drug Candidates to Clinical Translation	17
PREFACE	17
Recent Developments in Indazole Scaffold towards Prevention and Treatment of Various Health Disorders	17
Medicinal Chemistry for Sustainable Development	17
Preface	17
Recent Insights into Osimertinib Analogues against EGFR Positive Non-small Cell Lung Cancer	16
Isatin Derivatives as Emerging Promising Anti-Alzheimer Agents: Focusing on Their Chemical Structure and Biological Targets	16
Synthesis and Antimycobacterial Activity of Isoniazid Derivatives Tethered with Aliphatic Amines	16
Guchang Zhixie Pill: A Comprehensive Review of the Cl inical Applications, Toxicological Profile, and Quality Markers	16
An Update on Pharmacological and Phytochemical Aspects of Costus pictus D. Don - A Promising Anti-diabetic Plant	16
Advances in Small Molecules of Flavonoids for the Regulation of Gluconeogenesis	16

Recent Applications of Bioinformatics in Target Identification and Drug Discovery for Alzheimer’s Disease	16
A Compressive Review on Source, Toxicity and Biological Activity of Flavonoid	15
A Comprehensive Review on Phytochemistry and Pharmacology ofRosaSpecies (Rosaceae)	15
Phytochemicals of Biologically Active Fractions from Silene conoidea Leaves and Stems	15
Carboxamide: A Privileged Pharmacophore for the Development of Anti-infectious and Anti-cancer Drugs	15
A New Advanced Approach: Design and Screening of Affinity Peptide Ligands Using Computer Simulation Techniques	15
Application of Artificial Intelligence-Based Approaches in the Discovery and Development of Protein Kinase Inhibitors (PKIs) Targeting Anticancer Activity	15
Self-assembled Nucleic Acid Nanostructures for Biomedical Applications	14
The Potential of Secondary Metabolites from Plants as Drugs or Leads against Trypanosoma cruzi-An Update from 2012 to 2021	14
Recent Advances in the Multistep Continuous Preparation of APIs and Fine Chemicals	14
Lipoprotein-associated Phospholipase A2 in Coronary Artery Disease	14
Machine Learning and Artificial Intelligence: A Paradigm Shift in Big Data-Driven Drug Design and Discovery	14
Recent Developments in Microfluidic Paper-based Analytical Devices for Pharmaceutical Analysis	14
Multimodal Activity of a Novel Compound against Prostate and Pancreatic Cancer	14
A Review on Indole-triazole Molecular Hybrids as a Leading Edge in Drug Discovery: Current Landscape and Future Perspectives	13
The Role of Cytokines in Activation of Tumour-promoting Pathways and Emergence of Cancer Drug Resistance	13
Therapeutics for the Management of Cytokine Release Syndrome in COVID-19	13
100 Years of Insulin: A Historical Perspective	13
Profiling of Polyphenolic Compounds, Antioxidant, Antidyslipidemic and Cardiac Risk Preventive Effect of Keteki Joha and Kola Joha Rice Cultivars Grown in Assam, India: A Comparative Study	13
Drug Repurposing Meets DNA Independent Pathways: Targeting Alternative Substrates for Anticancer Therapy	13
A Concise Review on the Role of Natural and Synthetically Derived Peptides in Colorectal Cancer	13
Hybrid Compounds in Polypharmacology	13
Importance of Indazole against Neurological Disorders	13
Acknowledgement to Reviewers	13
Selected Natural and Synthetic Agents Effective against Parkinson’s Disease with Diverse Mechanisms	13
A Comprehensive Review on Current Perspectives of Flavonoids as Antimicrobial Agent	13
Prodrug Strategies for Critical Drug Developability Issues: Part II	12
Identification and Verification of a Prognostic Risk Signature in OralSquamous Cell Carcinoma	12
A Comprehensive Review on the Antimicrobial Activity of the Genus Artemisia, Artemisinin, and its Derivatives	12
Development and Exploration of Organic Compounds as Aldose Reductase Inhibitors: An Overview	12
Research Progress in Chemical Synthesis and Biosynthesis of Bioactive Pyridine Alkaloids	12
Pharmacological and Therapeutic Potential of Berbamine: A Potent Alkaloid from Genus Berberis	12
The Current Landscape in the Development of Small-molecule Modulators Targeting Sphingosine-1-phosphate Receptors to Treat Neurodegenerative Diseases	11
Antiviral Effects and Mechanisms of Green Tea Catechins on Influenza: A Perception on Combating Symptoms from COVID-19	11
Impact of TRP Channels in Oral Pathology and Therapeutic Targeting Options: A Narrative Review	11
Reviewing the Synthesis and Clinical Application of FDA-approved Anticancer Medications	11
Roles of C/EBPβ/AEP in Neurodegenerative Diseases	11
Thermally-Induced Self-Agglomeration: Method and First Approaches to the Structural, Mechanical and Biological Characterization of Nanofiber Scaffolds	11
Medicinal Chemistry Advancement in Life-Threatening Diseases	11
Advances in Nanomaterial-based Biosensors for Determination of Glycated Hemoglobin	10
Exploration of Computational Aids for Effective Drug Designing and Management of Viral Diseases: A Comprehensive Review	10
4-Nerolidylcatechol (4-NC) and Docetaxel Synergize in Controlling Androgen- independent Prostate Cancer Cells	10
Physicochemical Significance of Topological Indices: Importance in Drug Discovery Research	10
Molecular Modeling Techniques Applied to the Design of Multitarget Drugs: Methods and Applications	10
Bioassay Guided Isolation and α-Glucosidase Inhibition Studies of a New Sesquiterpene from Ochradenus aucheri	10
Adhesion Molecules as Prognostic Biomarkers in Coronary Artery Disease	10
Flavonoid: A Natural Scaffold with Modulatory Activities on Diverse Cellular Signaling Pathways Related to Complex Diseases	10
Coptis Chinensis Franch: Substance Basis, Mechanism of Action and Quality Control Standard Revealed Based on the Q-marker Concept and New Strategy of Systemic Pharmacology and Biosynthesis Rese	10
The Functional Mechanism and Structure-Activity Relationship of Antibacterial Peptides	10
Non-vesicular Lipid Transport Machinery in Trichomonas vaginalis: Novel Drug Targets against Trichomoniasis	10
Recent Advances in Drug Discovery for Parasitic Diseases	10
LINC-PINT: A Distinctive Long Non-Coding RNA Functioning as a Potential Suppressor in Tumorigenesis	10
A Review of the Biological Activities of Heterocyclic Compounds Comprising Oxadiazole Moieties	10
Psychedelics and Hallucinogens in Psychiatry: Finding New Pharmacological Targets	10
An Overview on Antifilarial Efficacy of Heterocyclic Motifs Encompassing Synthetic Strategies, SAR and Commercialized Medications	10
Antiproliferative Activity and Mechanisms of Action of Plant-derived Flavonoids on Breast Cancer	10
Review the Role of Metabolism Reprogramming in the Pathogenesis of Post-surgical Adhesion: A New Therapeutic Strategy	10
Use of Immunoglobulin Y Antibodies: Biosensor-based Diagnostic Systems and Prophylactic and Therapeutic Drug Delivery Systems for Viral Respiratory Diseases	10
Neuroprotective Role of Phytoconstituents-based Nanoemulsion for the Treatment of Alzheimer’s Disease	10
Phytochemicals for Human Health: The Emerging Trends and Prospects, Part-2	10
Decoding Dementia Mechanisms: Identification of Key Oligodendrocyte Associated Genes through Integrative Bioinformatics and MachineLearning	10
Recent Strategies and Challenges in Immunity and Nanomaterials for Cancer Therapy	10
Heterocyclic Phytochemicals as Anticancer Agents	10
Current Updates on Recent Developments in Artificial Intelligence in QSAR Modelling for Drug Discovery against Lung Cancer	9
A Mini Review on Pharmacological Significance of Isatin-1,2,3-Triazole Hybrids	9
Advances in the Study of Halogenated Natural Products	9
HDAC Inhibition as Neuroprotection in COVID-19 Infection	9
Benzothiazole as a Promising Scaffold for the Development of Antifungal Agents	9
1,3,4-Thiadiazole as a Structural Motif: Advances in SAR, and Drug Discovery Applications	9
In Silico and In Vivo Hepatorenal Protective Effect of Chitosan-Loaded Chrysin Nanoparticles in Obese Rats	9
A Comprehensive Review on the Application of Marketed Drugs as Ligands through Metallopharmaceutics	9
Naturally Occurring Steroidal Saponins as Potential Anticancer Agents: Current Developments and Mechanisms of Action	9
Noncoding RNAs in Alzheimer’s Disease: Overview of Functional and Therapeutic Significance	9
Ziziphi Spinosae Semen: A Natural Herb Resource for Treating Neurological Disorders	9
Multi-target Polypharmacology of 4-aminoquinoline Compounds against Malaria, Tuberculosis and Cancer	9
Navigating the Alzheimer's Treatment Landscape: Unraveling Amyloid-beta Complexities and Pioneering Precision Medicine Approaches	9
Neuroactive Phytoconstituents of Glycyrrhiza glabra for the Treatment of Alzheimer’s Disease	9
Employing “Red Flags” to Fight the Most Neglected Diseases: Nitroaromatic as Still Suitable Tools to Treat Human and Veterinary Parasitosis	9
Imidazole Scaffold Based Compounds in the Development of Therapeutic Drugs	9
Aminoglycosides with Anti-MRSA Activity: A Concise Review	9

The Design of Multi-target Drugs to Treat Cardiovascular Diseases: Two (or more) Birds on One Stone	9
Discovery of Diphenylsilane Compounds as Potential Inhibitors ofZn-Metalloproteinase Thermolysin Using Artificial Neural Networks	9
Biofunctionalized Nano-antimicrobials - Progress, Prospects and Challenges	8
Targeting c-Met in Cancer Therapy: Unravelling Structure-activity Relationships and Docking Insights for Enhanced Anticancer Drug Design	8
FDA-Approved Fluorine-Containing Molecules in 2024: Significance, Synthesis, and Therapeutic Applications	8
Recent Efforts in the Discovery of Urease Inhibitor Identifications	8
Probing the Interaction of Selonsertib with Human Serum Albumin: In silico and In vitro Approaches	8
A Comprehensive Review of mRNA-based Vaccines for COVID-19, A New Era in Pharmaceuticals: Unspecified and Unknown Aspects, Effects and Challenges	8
Hybrid Molecules with Potential Activity Against Methicillin-resistance Staphylococcus aureus Part I	8
Recent Development of Heterocyclic Compounds with Indazole Moiety as Potential Antiparasitic Agents	8
Quantitative Structure Activity/Toxicity Relationship through Neural Networks for Drug Discovery or Regulatory Use	8
Oxyprenylated Secondary Metabolites as Modulators of Lipid and Sugar Metabolism	8
Unveiling Anti-Cancer Potential through ADMET Prediction, MolecularDocking, Molecular Dynamics, and In vitro Analysis: Approach toEstablish Alpha-Terpineol as a Potential Drug Candidate against Glioma	8
Thiazolidine Derivatives: An Up-to-Date Review of Synthesis and Biological Activity	8
A Review on Aptamers Selection and Application in Heart Diseases Diagnosis	8
Stimuli-sensitive Chitosan-based Nanosystems-immobilized Nucleic Acids for Gene Therapy in Breast Cancer and Hepatocellular Carcinoma	8
Nanomaterial-based Electrochemical Sensors for Multiplex Medicinal Applications	8
Green Synthetic and Pharmacological Developments in the Hybrid Quinazolinone Moiety: An Updated Review	8
Neurobiology of Dream Activity and Effects of Stimulants on Dream	8
A Review of Computational Approaches Targeting SARS-CoV-2 Main Protease to the Discovery of New Potential Antiviral Compounds	8
Molecular Characterization of Primary and Metastatic Colon Cancer Cells to Identify Therapeutic Targets with Natural Compounds	8
Synthesis, X-Ray Structure, Characterization, Antifungal Activity, DFT, and Molecular Simulation of a Novel Pyrazole Carboxylic Acid	8
Harnessing the Therapeutic Potential of Antimicrobial Peptides for Cancers: State of the Art	8
A Comprehensive Review of Pharmacokinetics and Pharmacodynamics in Animals: Exploration of Interaction with Antibiotics of Shuang-Huang- Lian Preparations	8
Polymer Conjugate as the New Promising Drug Delivery System for Combination Therapy against Cancer	7
5-Membered Heterocyclic Compounds as Antiviral Agents	7
Mechanisms of Metallic Nanomaterials to Induce an Antibacterial Effect	7
Recent Advances in Di-, Tri-Substituted Mono-Thiazoles, and Bis-Thiazoles: Factors Affecting Biological Activities, Future Aspects, and Challenges	7
Therapeutic Potential of Quercetin in Diabetic Neuropathy and Retinopathy: Exploring Molecular Mechanisms	7
Targeting Various Pathogenic Pathways for the Development of Anti-alzheimer’s Drugs: An Update	7
Zingerone Induces Apoptosis and Ferroptosis in Prostate Cancer DU145 Cells	7
Mining of Targeted Therapeutic Drugs for Hepatocellular Carcinoma based on Programmed Cell Death-related Features and Construction of an Imaging Histology Diagnostic Model	7
Viral Vertical Transmission through the Placenta: The Potential ofNatural Products as Therapeutic and Prophylactic Antiviral Agents	7
SRT1720 Treatments Hepatic Ischemia Reperfusion Injury by Regulation of NF-κB Signaling Pathways and Reduce Cell Apoptosis: From Network Pharmacology to Experimental Validation	7
Ethnobotanical Study of Knowledge and Herbal Recipes of Medicinal Plants in Ancient Izki, Al Dakhliya Region, Sultanate of Oman	7
Synthesis and In vitro and In silico Anti-inflammatory Activity of New Thiazolidinedione-quinoline Derivatives	7
Recent Advances in the Development of Nitrogen-containing Heterocyclic Anti-alzheimer’s Agents	7
Exploring the Structure-Activity Relationship of COX Inhibitors with Anticancer Effects: A Comprehensive Review	7
The Impact and Role of Artificial Intelligence (AI) in Healthcare: Systematic Review	7
Recent Advances in Chemical Composition and Transdermal Delivery Systems for Topical Bio-actives in Skin Cancer	7
An Updated Overview of Synthetic α-glucosidase Inhibitors: Chemistry and Bioactivities	7
Ameliorative Effects of Essential Oils on Diabetes Mellitus: A Review	7
Nano-cocrystals as Nanotechnology-based Approach to Modulate Solubility and Bioavailability of Poorly Soluble Drugs	7
Clinical Research Progress of BTK Inhibitors in the Treatment of Autoimmune Diseases	7
Pharmacological Chemistry and Biomedical Implications of Chemical Ingredients from Parthenium hysterophorus	7
Transforming Breast Cancer Therapy: The Pivotal Role of Nanoparticles	7
Recent Advances in Nanocatalyzed One-Pot Sustainable Synthesis of Bioactive N, N-Heterocycles with Anticancer Activities: An Outlook of Medicinal Chemistry	7
Melanin Synthesized by the Endophytic Aureobasidium Pullulans AKW: A Multifaceted Biomolecule with Antioxidant, Wound Healing, and Selective Anti-Cancer Activity	7
Advancements and Scientific Partnerships in the Application of Polysaccharides in Oral Formulations: A Bibliometric Analysis and Review	7
Natural Products as Sources of Multitarget Compounds: Advances in the Development of Ferulic Acid as Multitarget Therapeutic	7
The Vital Role of Long Non-Coding RNA SUMO1P3 in the Regulation of Human Cancer: Current Perspectives and Future Challenges	7