Current Topics in Medicinal Chemistry

Article	Citations
Privileged Scaffold for Drug Design and Activity Improvement - Part IV	113
Recent Developments in the Therapeutics for Endocrine Diseases	67
Recent Advances in the Use of Multitarget Therapeutics	66
The Role of Herbal Medicine in Modulating Bone Homeostasis	62
Fighting Antimicrobial Resistance with Natural Products - Current Developments and Future Prospects	51
Qi Yin San Liang San Decoction Relieves Gefitinib-Induced Diarrhea via the Modulation of Chemokines and Innate Immune Responses	48
Next-generation Bruton’s Tyrosine Kinase (BTK) Inhibitors Potentially Targeting BTK C481S Mutation- Recent Developments and Perspectives	45
Synthesis of Isatin-derived Heterocycles with Promising Anticancer Activities	45
From Nature to Drug: Overview and CADD Approach of Anacardic Acid to Propose their Biological Potential	44
Green Synthesis of Biorelevant Scaffolds through Organocatalytic/ Enzymatic Dynamic Kinetic Resolution	40
Optimization, Preparation, and Cytotoxic Potential of Pyrus communis Extract Loaded Ethosomes on Skin Cancer Cell Lines	39
Tackling Nontuberculous Mycobacteria by Repurposable Drugs and Potential Leads from Natural Products	36
Valeriana jatamansi: Bioactive Compounds and their Medicinal Uses	36
Application of Virtual Sample Generation and Screening in Process Parameter Optimization of Botanical Medicinal Materials	35
Discovery of MMP1 Inhibitors from Dandelion using Molecular Simulation and Bioactivity Test	35
Computer-aided Drug Discovery of Epigenetic Modulators in Dual-target Therapy of Multifactorial Diseases	33
Modern Approaches to Diabetes: The Role of Phytochemicals in Targeting Molecular Receptors	31
Bioactivity of Natural Products as Complementary Medicine	30
Eco-friendly Approaches to Chromene Derivatives: A Comprehensive Review of Green Synthesis Strategies	30
The Gut Microbiota-Brain Axis: Potential Mechanism of Drug Addiction	30
Current Advances in Drug Design and Cancer Research	28
Natural Multi-targets: Advances and Applications	28
Hydrogen-producing Photocatalyst at Sunscreen for Athletes in Preventing and Healing Muscle-nerve-skin Injuries	27
Probing into the Flap-dimer Dynamics of the Mycobacterium tuberculosis Kasa Enzyme Binding Landscape Provides the Underlying Inhibitory Mechanisms of JSF-3285 and 5G	26
Recent Advances in the Design and Synthesis of Small Molecule Carbonic Anhydrase IX Inhibitors	26

Insight into the Recent Developments of Nanoparticles in Treatment of Cancer and Neuro-Degenerative Disease: A Review	26
Recent Medicinal Chemistry Studies against Neglected Diseases	25
The Multitarget Action of Vitamins in the Ischemic Stroke	25
Bioanalysis, Analysis, Chemistry, and Pharmacological Aspects of Hypoxia-Inducible Factor Prolyl Hydroxylase Inhibitors	25
Recent Advances in Metallic Nanostructures-assisted Biosensors for Medical Diagnosis and Therapy	25
Nutritional Value, Therapeutic Effects, Phytochemistry, and Toxicology of Lepisanthes fruticosa: A Review	24
Effect of Withaferin-A, Withanone, and Caffeic Acid Phenethyl Ester on DNA Methyltransferases: Potential in Epigenetic Cancer Therapy	24
Artificial Intelligence and Cheminformatics-Guided Modern Privileged Scaffold Research	23
Repurposing some of the Well-known Non-steroid Anti-inflammatory Drugs (NSAIDs) for Cancer Treatment	23
Current Organoid Culture Systems in Pancreatic Cancer	23
Wnt/β-catenin Signaling Inhibitors	23
Rheumatoid Arthritis: Pathogenesis, Therapeutic Strategies, Advances, and Structural Activity Relationships of Synthesized Agents	23
Cinchonine: A Versatile Pharmacological Agent Derived from Natural Cinchona Alkaloids	23
Calotropis procera (Aiton) Dryand (Apocynaceae): State of the art of its uses and Applications	22
Finding Integrative Medication for Neuroblastoma and Glioblastoma through Zebrafish as A Model of Organism	22
Review on the Developments of Benzothiazole-containing Antimicrobial Agents	22
Oxidative Stress Biomarkers in Coronary Artery Disease	22
QSAR into the New Millennium: Structural, Topological, Quantum, Shape, Electronic and Bio Descriptors for Machine Learning & AI - Honoring Prof. Satya Prakash Gupta	21
Epigenetics Mechanism and Therapeutic Potential of Approved Epi-drugs in Pulmonary Hypertension Disease	21
Drug Delivery Systems for Natural Medicines in Cancer Therapy	21
To Investigate Growth Factor Receptor Targets and Generate Cancer Targeting Inhibitors	21
Novel Therapeutic Strategies for the Management of Neuropathology and Neuroprotection in COVID-19	20
Novel Biomarkers in Cardiovascular Diseases: Going beyond Troponins and Natriuretic Peptides - Part 1	20
Acknowledgements to Reviewers	20
Biosensors in Diagnostics and Medicinal Applications Part (II)	19
Role of Plant Materials with Anti-inflammatory Effects in Phytotherapy of Osteoarthritis	19
Various Effects of the GABAergic System on Cancer: The Conditions and Specificities of its use in the Treatment of Some Cancers	19
Insight into Tumor Hypoxia: Radionuclide-based Biomarker as Diagnostic Tools	19
Exploring New Vista for Alzheimer's Disease Drug Targets	19
Highlighting the Therapeutic Potential of an Underexplored Target: Human Dihydroorotate Dehydrogenase in Cancer, Rheumatoid Arthritis and Sclerosis	18
Synthesis of Biorelevant Scaffolds under Greener Conditions (Part: 2)	18
Medicinal Chemistry and Target Identification of Synthetic Clinical and Advanced Preclinical Antimalarial Candidates (2000 - 2022)	18
Precision Psychiatry: Machine Learning as a Tool to Find New Pharmacological Targets	18
Recent Studies on Neglected Drug Design	18
Effects of Flavonoids in Experimental Models of Arterial Hypertension	18
Conformation Study and Design of Novel 6-Hydroxybenzothiazole-2- Carboxamides as Potentially Potent and Selective Monoamine Oxidase B Inhibitors for Neuroprotection	18
Guchang Zhixie Pill: A Comprehensive Review of the Clinical Applications, Toxicological Profile, and Quality Markers	17
Recent Developments in Indazole Scaffold towards Prevention and Treatment of Various Health Disorders	17
Recent Biochemical Advances in Antitubercular Drugs: Challenges and Future	17
Lipoprotein-associated Phospholipase A2 in Coronary Artery Disease	17
Preface	17
Chemical Composition, Acetylcholine Esterase and Anti-bacterial Activities of Essential Oils of Elaeosilenum thapsioides (Desf.) Maire from Algeria	17
Multimodal Activity of a Novel Compound against Prostate and Pancreatic Cancer	17
Advances in Small Molecules of Flavonoids for the Regulation of Gluconeogenesis	17
Plant-food-derived Bioactives in Managing Hypertension: From Current Findings to Upcoming Effective Pharmacotherapies	17
Phytotherapeutics in Cancer: From Potential Drug Candidates to Clinical Translation	16
A New Advanced Approach: Design and Screening of Affinity Peptide Ligands Using Computer Simulation Techniques	16
Medicinal Chemistry for Sustainable Development	16
Recent Developments in Microfluidic Paper-based Analytical Devices for Pharmaceutical Analysis	16
Phytochemicals of Biologically Active Fractions from Silene conoidea Leaves and Stems	16

Recent Applications of Bioinformatics in Target Identification and Drug Discovery for Alzheimer’s Disease	16
Application of Artificial Intelligence-Based Approaches in the Discovery and Development of Protein Kinase Inhibitors (PKIs) Targeting Anticancer Activity	16
The Potential of Secondary Metabolites from Plants as Drugs or Leads against Trypanosoma cruzi-An Update from 2012 to 2021	15
Profiling of Polyphenolic Compounds, Antioxidant, Antidyslipidemic and Cardiac Risk Preventive Effect of Keteki Joha and Kola Joha Rice Cultivars Grown in Assam, India: A Comparative Study	15
A Comprehensive Review on Phytochemistry and Pharmacology ofRosaSpecies (Rosaceae)	15
An Update on Pharmacological and Phytochemical Aspects of Costus pictus D. Don - A Promising Anti-diabetic Plant	15
Recent Advances in the Multistep Continuous Preparation of APIs and Fine Chemicals	15
Recent Insights into Osimertinib Analogues against EGFR Positive Non-small Cell Lung Cancer	15
Importance of Indazole against Neurological Disorders	14
Synthesis and Antimycobacterial Activity of Isoniazid Derivatives Tethered with Aliphatic Amines	14
A Review on Indole-triazole Molecular Hybrids as a Leading Edge in Drug Discovery: Current Landscape and Future Perspectives	13
Carboxamide: A Privileged Pharmacophore for the Development of Anti-infectious and Anti-cancer Drugs	13
Bioactivity of Natural Products as Complementary Medicine-Part II	13
Inhibitory Potential of Dietary Nutraceuticals on Cellular PI3K/Akt Signaling: Implications in Cancer Prevention and Therapy	13
Machine Learning and Artificial Intelligence: A Paradigm Shift in Big Data-Driven Drug Design and Discovery	13
Drug Repurposing Meets DNA Independent Pathways: Targeting Alternative Substrates for Anticancer Therapy	13
Identification and Verification of a Prognostic Risk Signature in Oral Squamous Cell Carcinoma	13
A Compressive Review on Source, Toxicity and Biological Activity of Flavonoid	13
The Role of Cytokines in Activation of Tumour-promoting Pathways and Emergence of Cancer Drug Resistance	13
Self-assembled Nucleic Acid Nanostructures for Biomedical Applications	13
A Comprehensive Review on the Antimicrobial Activity of the Genus Artemisia, Artemisinin, and its Derivatives	12
Flavonoid Derivatives Targeting BCR-ABL Kinase: Semisynthesis, Molecular Dynamic Simulations and Enzymatic Inhibition	12
A Concise Review on the Role of Natural and Synthetically Derived Peptides in Colorectal Cancer	12
Recent Progress in 1H-1,2,3-triazoles as Potential Antifungal Agents	12
100 Years of Insulin: A Historical Perspective	12
Selected Natural and Synthetic Agents Effective against Parkinson’s Disease with Diverse Mechanisms	12
Acknowledgement to Reviewers	12
Hybrid Compounds in Polypharmacology	12
A Comprehensive Review on Current Perspectives of Flavonoids as Antimicrobial Agent	12
Pharmacological and Therapeutic Potential of Berbamine: A Potent Alkaloid from Genus Berberis	12
Therapeutics for the Management of Cytokine Release Syndrome in COVID-19	11
Antiviral Effects and Mechanisms of Green Tea Catechins on Influenza: A Perception on Combating Symptoms from COVID-19	11
Reviewing the Synthesis and Clinical Application of FDA-approved Anticancer Medications	11
Prodrug Strategies for Critical Drug Developability Issues: Part II	11
Physicochemical Significance of Topological Indices: Importance in Drug Discovery Research	11
Impact of TRP Channels in Oral Pathology and Therapeutic Targeting Options: A Narrative Review	11
Thermally-Induced Self-Agglomeration: Method and First Approaches to the Structural, Mechanical and Biological Characterization of Nanofiber Scaffolds	11
Molecular Modeling Techniques Applied to the Design of Multitarget Drugs: Methods and Applications	11
Roles of C/EBPβ/AEP in Neurodegenerative Diseases	11
Medicinal Chemistry Advancement in Life-Threatening Diseases	11
The Current Landscape in the Development of Small-molecule Modulators Targeting Sphingosine-1-phosphate Receptors to Treat Neurodegenerative Diseases	11
LINC-PINT: A Distinctive Long Non-Coding RNA Functioning as a Potential Suppressor in Tumorigenesis	10
HDAC Inhibition as Neuroprotection in COVID-19 Infection	10
Recent Advances in Drug Discovery for Parasitic Diseases	10
Bioassay Guided Isolation and α-Glucosidase Inhibition Studies of a New Sesquiterpene from Ochradenus aucheri	10
Neuroprotective Role of Phytoconstituents-based Nanoemulsion for the Treatment of Alzheimer’s Disease	10
4-Nerolidylcatechol (4-NC) and Docetaxel Synergize in Controlling Androgen- independent Prostate Cancer Cells	10
Use of Immunoglobulin Y Antibodies: Biosensor-based Diagnostic Systems and Prophylactic and Therapeutic Drug Delivery Systems for Viral Respiratory Diseases	10
Non-vesicular Lipid Transport Machinery in Trichomonas vaginalis: Novel Drug Targets against Trichomoniasis	10
Flavonoid: A Natural Scaffold with Modulatory Activities on Diverse Cellular Signaling Pathways Related to Complex Diseases	10
A Review of the Biological Activities of Heterocyclic Compounds Comprising Oxadiazole Moieties	10
Noncoding RNAs in Alzheimer’s Disease: Overview of Functional and Therapeutic Significance	10
Review the Role of Metabolism Reprogramming in the Pathogenesis of Post-surgical Adhesion: A New Therapeutic Strategy	10
Phytochemicals for Human Health: The Emerging Trends and Prospects, Part-2	10
Recent Strategies and Challenges in Immunity and Nanomaterials for Cancer Therapy	9
Psychedelics and Hallucinogens in Psychiatry: Finding New Pharmacological Targets	9
Multi-target Polypharmacology of 4-aminoquinoline Compounds against Malaria, Tuberculosis and Cancer	9
Advances in Nanomaterial-based Biosensors for Determination of Glycated Hemoglobin	9
A Mini Review on Pharmacological Significance of Isatin-1,2,3-Triazole Hybrids	9
Navigating the Alzheimer's Treatment Landscape: Unraveling Amyloid-beta Complexities and Pioneering Precision Medicine Approaches	9
Exploration of Computational Aids for Effective Drug Designing and Management of Viral Diseases: A Comprehensive Review	9
Adhesion Molecules as Prognostic Biomarkers in Coronary Artery Disease	9
Green Synthetic and Pharmacological Developments in the Hybrid Quinazolinone Moiety: An Updated Review	9
Discovery of Diphenylsilane Compounds as Potential Inhibitors of Zn-Metalloproteinase Thermolysin Using Artificial Neural Networks	9
Antiproliferative Activity and Mechanisms of Action of Plant-derived Flavonoids on Breast Cancer	9
The Design of Multi-target Drugs to Treat Cardiovascular Diseases: Two (or more) Birds on One Stone	9
Naturally Occurring Steroidal Saponins as Potential Anticancer Agents: Current Developments and Mechanisms of Action	9
Heterocyclic Phytochemicals as Anticancer Agents	9
1,3,4-Oxadiazoles as Potential Pharmacophore for Cytotoxic Potentiality: A Comprehensive Review	9
A Comprehensive Review on the Application of Marketed Drugs as Ligands through Metallopharmaceutics	9
Coptis Chinensis Franch: Substance Basis, Mechanism of Action and Quality Control Standard Revealed Based on the Q-marker Concept and New Strategy of Systemic Pharmacology and Biosynthesis Rese	9
Employing “Red Flags” to Fight the Most Neglected Diseases: Nitroaromatic as Still Suitable Tools to Treat Human and Veterinary Parasitosis	9
An Overview on Antifilarial Efficacy of Heterocyclic Motifs Encompassing Synthetic Strategies, SAR and Commercialized Medications	9
The Functional Mechanism and Structure-Activity Relationship of Antibacterial Peptides	9
Targeting c-Met in Cancer Therapy: Unravelling Structure-activity Relationships and Docking Insights for Enhanced Anticancer Drug Design	8
Neurobiology of Dream Activity and Effects of Stimulants on Dream	8
Juglone: A Versatile Natural Platform for Obtaining New Bioactive Compounds	8
Neuroactive Phytoconstituents of Glycyrrhiza glabra for the Treatment of Alzheimer’s Disease	8
Unveiling Anti-Cancer Potential through ADMET Prediction, Molecular Docking, Molecular Dynamics, and In vitro Analysis: Approach to Establish Alpha-Terpineol as a Potential Drug Candidate against Glio	8
Quantitative Structure Activity/Toxicity Relationship through Neural Networks for Drug Discovery or Regulatory Use	8

A Comprehensive Review of mRNA-based Vaccines for COVID-19, A New Era in Pharmaceuticals: Unspecified and Unknown Aspects, Effects and Challenges	8
Recent Efforts in the Discovery of Urease Inhibitor Identifications	8
Molecular Characterization of Primary and Metastatic Colon Cancer Cells to Identify Therapeutic Targets with Natural Compounds	8
Update on Modulators of Quorum Sensing Pathways in Pseudomonas aeruginosa	8
Aminoglycosides with Anti-MRSA Activity: A Concise Review	8
Imidazole Scaffold Based Compounds in the Development of Therapeutic Drugs	8
Nutraceuticals and Bio-inspired Materials from Microalgae and their Future Perspectives	8
Recent Development of Heterocyclic Compounds with Indazole Moiety as Potential Antiparasitic Agents	8
Nanomaterial-based Electrochemical Sensors for Multiplex Medicinal Applications	8
Relevance of Aromatase Inhibitors in Breast Cancer Treatment	8
A Review of Computational Approaches Targeting SARS-CoV-2 Main Protease to the Discovery of New Potential Antiviral Compounds	8
A Comprehensive Review of Pharmacokinetics and Pharmacodynamics in Animals: Exploration of Interaction with Antibiotics of Shuang-Huang- Lian Preparations	8
Ziziphi Spinosae Semen: A Natural Herb Resource for Treating Neurological Disorders	8
Advances in the Study of Halogenated Natural Products	8
Benzothiazole as a Promising Scaffold for the Development of Antifungal Agents	8
Biofunctionalized Nano-antimicrobials - Progress, Prospects and Challenges	8
Stimuli-sensitive Chitosan-based Nanosystems-immobilized Nucleic Acids for Gene Therapy in Breast Cancer and Hepatocellular Carcinoma	8
Hybrid Molecules with Potential Activity Against Methicillin-resistance Staphylococcus aureus Part I	8
Oxyprenylated Secondary Metabolites as Modulators of Lipid and Sugar Metabolism	8
An Updated Overview of Synthetic α-glucosidase Inhibitors: Chemistry and Bioactivities	7
Recent Advances in Di-, Tri-Substituted Mono-Thiazoles, and Bis-Thiazoles: Factors Affecting Biological Activities, Future Aspects, and Challenges	7
Recent Advances in Chemical Composition and Transdermal Delivery Systems for Topical Bio-actives in Skin Cancer	7
Natural Products as Sources of Multitarget Compounds: Advances in the Development of Ferulic Acid as Multitarget Therapeutic	7
Mining of Targeted Therapeutic Drugs for Hepatocellular Carcinoma based on Programmed Death-related Features and Construction of an Imaging Histology Diagnostic Model	7
Pharmacological Chemistry and Biomedical Implications of Chemical Ingredients from Parthenium hysterophorus	7
SRT1720 Treatments Hepatic Ischemia Reperfusion Injury by Regulation of NF-κB Signaling Pathways and Reduce Cell Apoptosis: From Network Pharmacology to Experimental Validation	7
Polymer Conjugate as the New Promising Drug Delivery System for Combination Therapy against Cancer	7
In vivo PET Imaging of EGFR Expression: An Overview of Radiolabeled EGFR TKIs	7
The Impact and Role of Artificial Intelligence (AI) in Healthcare: Systematic Review	7
Advancements and Scientific Partnerships in the Application of Polysaccharides in Oral Formulations: A Bibliometric Analysis and Review	7
Mechanisms of Metallic Nanomaterials to Induce an Antibacterial Effect	7
Targeting Various Pathogenic Pathways for the Development of Anti-alzheimer’s Drugs: An Update	7
A Review on Aptamers Selection and Application in Heart Diseases Diagnosis	7
Recent Advances in the Development of Nitrogen-containing Heterocyclic Anti-alzheimer’s Agents	7
Harnessing the Therapeutic Potential of Antimicrobial Peptides for Cancers: State of the Art	7
Melanin Synthesized by the Endophytic Aureobasidium Pullulans AKW: A Multifaceted Biomolecule with Antioxidant, Wound Healing, and Selective Anti-Cancer Activity	7
Microfluidics-mediated Liposomal Nanoparticles for Cancer Therapy: Recent Developments on Advanced Devices and Technologies	7
5-Membered Heterocyclic Compounds as Antiviral Agents	7
MicroRNAs as Potential Biomarkers in Coronary Artery Disease	7
Exploring the Structure-Activity Relationship of COX Inhibitors with Anticancer Effects: A Comprehensive Review	7
The Vital Role of Long Non-Coding RNA SUMO1P3 in the Regulation of Human Cancer: Current Perspectives and Future Challenges	7
Recent Advances in Nanocatalyzed One-Pot Sustainable Synthesis of Bioactive N, N-Heterocycles with Anticancer Activities: An Outlook of Medicinal Chemistry	7
Synthesis, X-Ray Structure, Characterization, Antifungal Activity, DFT, and Molecular Simulation of a Novel Pyrazole Carboxylic Acid	7
Ameliorative Effects of Essential Oils on Diabetes Mellitus: A Review	7
Therapeutic Potential of Quercetin in Diabetic Neuropathy and Retinopathy: Exploring Molecular Mechanisms	7
Transforming Breast Cancer Therapy: The Pivotal Role of Nanoparticles	7
Probing the Interaction of Selonsertib with Human Serum Albumin: In silico and In vitro Approaches	7
Electrochemical Protein-based Bioanalytical Devices for Drug Analysis	7
Clinical Research Progress of BTK Inhibitors in the Treatment of Autoimmune Diseases	7
The Translational Potential of Non-coding RNAs and Multimodal MRI Data Sets as Diagnostic and Differential Diagnostic Biomarkers for Mood Disorders	7
Current Therapeutic Strategies for the Management of Benzodiazepine (BZD) Withdrawal Syndrome: A Review	6
Clinical Indicators of Oral Frailty: A Domain-Specific Frailty Phenotype	6
Protein Dynamics Mediated by Cardiolipin in Bacteria	6
Synthesis and In vitro and In silico Anti-inflammatory Activity of New Thiazolidinedione-quinoline Derivatives	6
Ethnobotanical Study of Knowledge and Herbal Recipes of Medicinal Plants in Ancient Izki, Al Dakhliya Region, Sultanate of Oman	6
Natural Antioxidants as Additional Weapons in the Fight against Malarial Parasite	6
Nanocarriers as Administration Systems of Natural Products	6
Therapeutic Potential of Quercetin in Type 2 Diabetes Based on a Network Pharmacology Study	6
Synthetic Strategies for the Development of Ibuprofen Derivatives: A Classified Study	6
Integrative Analysis Reveals Genes Causal Relation with Ovarian Cancer and aging	6
The General Neurocognitive Decline in Patients with Methamphetamine Use and Transient Methamphetamine-induced Psychosis is Primarily Determined by Oxidative and AGE-RAGE Stress	6
2,3-Diarylindoles as COX-2 Inhibitors: Exploring the Structure-activity Relationship through Molecular Docking Simulations	6
Non-fused Pyrimidine Derivatives as Potential Pharmacological Entities: A Review	6
CADD Methods for Developing Novel Compounds Synthesized to Inhibit Tyrosine Kinase Receptors	6
Advances in Cervical Cancer Diagnostics Based on Immunosensors: Innovative Approaches and Tumor Biomarkers	6
Bergenin - A Biologically Active Scaffold: Nanotechnological Perspectives	6
Nanoscale Structures and Materials from the Self-assembly of Polypeptides and DNA	6
Natural Plant Products Mediated Prevention of Cancer Facilitated through Immune Suppression of Treg Cells	6
Facile Synthesis and Applications of Flavonoid-Heterocyclic Derivatives	6
Oxazolidinone-containing Hybrids with Antibacterial Activity against Methicillin-resistant Staphylococcus aureus (MRSA): A Mini-review	6
Anti-apoptotic and Anti-oxidative Effects of Aqueous Extract prepared from Steamed Daylily Flower in Normal Cardiac and Hepatic Cells against Ethanol.	6
Coumarin as a Privileged and Medicinally Important Scaffold in the Treatment of Tuberculosis	6
Synthesis of New Axially Coumarin Disubstituted Silicon(IV) Phthalocyanines, Investigation of their DNA-Binding Properties and Inhibitory Activities on Ache and Buche	6
The Computational Tools to Identify DNA Repeats and Motifs: A Systematic Review	6
1,2,3-Triazole Derivatives with Anti-breast Cancer Potential	6
The Future of Medicine: AI and ML Driven Drug Discovery Advancements	6