Ageing Research Reviews

Papers
(The H4-Index of Ageing Research Reviews is 77. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2022-01-01 to 2026-01-01.)
ArticleCitations
Start the engine of neuroregeneration: A mechanistic and strategic overview of direct astrocyte-to-neuron reprogramming599
Editorial Board286
The unique neuropathological vulnerability of the human brain to aging278
The functions of IRE1α in neurodegenerative diseases: Beyond ER stress250
Roles of hypoxia-inducible factor-prolyl hydroxylases in aging and disease242
Rethinking IRPs/IRE system in neurodegenerative disorders: Looking beyond iron metabolism239
Editorial Board191
Medication reviews in hospitalised patients for reduced hospital readmission and mortality. Systematic review, meta-analysis and meta-regression of RCTs190
Advances in clinical application of lipidomics in healthy ageing and healthy longevity medicine190
HIV infection is associated with accelerated epigenetic ageing: A systematic review185
Editor’s Note to “Biological constraint, evolutionary spandrels and antagonistic pleiotropy”185
Type 2 diabetes mellitus augments Parkinson’s disease risk or the other way around: Facts, challenges and future possibilities165
Histopathological and ultrastructural changes in different cell types during ischemic and hemorrhagic stroke160
Sarcobesity: New paradigms for healthy aging related to taurine supplementation, gut microbiota and exercise157
Thioredoxin-1 inhibits the activation of IRE1 by targeting Hsp90/p-Cdc37 chaperone complex in Parkinson disease153
Unravelling the brain resilience following stroke: From injury to rewiring of the brain through pathway activation, drug targets, and therapeutic interventions151
Dysfunction of norepinephrine and its metabolites in Alzheimer's dementia – A review with meta-analysis150
Reevaluating principal component analysis in geroscience: A call for nonlinear approaches in AI-based evaluations142
CC chemokines family in fibrosis and aging: From mechanisms to therapy141
Microglia and gut microbiota: A double-edged sword in Alzheimer's disease134
Ergothioneine and exercise: A match made in (cognitive) heaven?132
Can dementia risk be reduced by following the American Heart Association's Life's Simple 7? A systematic review and dose-response meta-analysis129
cGAS-STING-driven inflammaging cascade in aging-related retinal diseases: From pathological mechanism to therapeutic potentials127
Efficacy of technology-based cognitive and exercise interventions for mild cognitive impairment: A systematic review, network meta-analysis, and meta-regression of randomized controlled trials127
Cerebral glymphatic system: Structure, regulation, ageing, and mechanisms of encephalopathy126
The past, present, and future of adipose tissue browning and aging: A review combined with bibliometrics and bioinformatics of 2527 documents published over the past four decades125
Artificial intelligence in brain MRI analysis of Alzheimer’s disease over the past 12 years: A systematic review124
Discovery of a new hereditary RECQ helicase disorder RECON syndrome positions the replication stress response and genome homeostasis as centrally important processes in aging and age-related disease122
Does drug repurposing bridge the gaps in management of Parkinson’s disease? Unravelling the facts and fallacies120
Global, regional, and national burden of spinal cord injury from 1990 to 2021 and projections for 2050: A systematic analysis for the Global Burden of Disease 2021 study119
Glymphatic dysfunction in Parkinson's disease: Aging-associated impairments, imaging biomarkers, and therapeutic strategies119
Guardians of homeostasis: Natural products target metabolic reprogramming in Alzheimer’s disease116
Prevalence and health outcomes of polypharmacy and hyperpolypharmacy in older adults with frailty: A systematic review and meta-analysis116
Repetitive transcranial magnetic stimulation combined with cognitive training for cognitive function and activities of daily living in patients with post-stroke cognitive impairment: A systematic revi112
Optimal dose and type of exercise to improve cognitive function in older adults: A systematic review and bayesian model-based network meta-analysis of RCTs112
Adenosine metabolism and receptors in aging of the skin, musculoskeletal, immune and cardiovascular systems111
Unraveling the protein post-translational modification landscape: Neuroinflammation and neuronal death after stroke110
Effectiveness of virtual reality interventions on quality of life, cognitive function and physical function in older people with Alzheimer's disease: A systematic review109
Advances in Alzheimer's therapy: Exploring neuropathological mechanisms to revolutionize the future therapeutic landscape108
Vascular cognitive impairment – Past, present, and future challenges106
The mitochondrial integrated stress response: A novel approach to anti-aging and pro-longevity105
Bridging neurotrophic factors and bioactive peptides to Alzheimer's disease104
Hallmarks of aging: A user’s guide for comparative biologists99
The role of the PLA2G6 gene in neurodegenerative diseases99
The several ways to authentically cure Alzheimer’s dementia98
Insulin resistance as a mediator of physical activity's effects on beta-amyloid accumulation and tau phosphorylation: A scoping review98
The role of the gut microbiota in neuropsychiatric disorders and therapy98
Potential convergence of olfactory dysfunction in Parkinson’s disease and COVID-19: The role of neuroinflammation97
Neuroprotection by agmatine: Possible involvement of the gut microbiome?96
Overview of pro-inflammatory and pro-survival components in neuroinflammatory signalling and neurodegeneration94
Protein and peptide based nanotherapeutics for the management of Alzheimer’s disease: Current insights and future directions94
Triaging between post-translational modification of cell cycle regulators and their therapeutics in neurodegenerative diseases93
Role of diet and exercise in aging, Alzheimer’s disease, and other chronic diseases91
Betaine and aging: A narrative review of findings, possible mechanisms, research perspectives, and practical recommendations89
Biomarkers associated with cognitive impairment in post-traumatic stress disorder: A systematic review of current evidence88
Interventions to prevent and treat delirium: An umbrella review of randomized controlled trials88
Identification of exosomal biomarkers and its optimal isolation and detection method for the diagnosis of Parkinson's disease: A systematic review and meta-analysis88
Advances of artificial intelligence in predicting frailty using real-world data: A scoping review87
Cytosolic DNA sensor IFI16 proteins: Potential molecular integrators of interactions among the aging hallmarks86
Unravelling the miscellaneous effects of exercise interventions on activities of daily living in frail older adults: A systematic review and meta-analysis86
Three-dimensional human brain organoids: A next-generation model to decode Alzheimer’s disease84
Artificial intelligence for fall detection in older adults: A comprehensive survey of machine learning, deep learning approaches, and future directions84
The effectiveness of dance movement interventions for older adults with mild cognitive impairment, Alzheimer’s disease, and dementia: A systematic scoping review and meta-analysis84
Involvement of regulated cell deaths in aging and age-related pathologies83
Cognitive resilience in Alzheimer’s disease: Mechanism and potential clinical intervention82
Adherence to the Mediterranean diet and risk of frailty and pre-frailty in elderly adults: A systematic review and dose-response meta-analysis with GRADE assessment82
On the wake of metformin: Do anti-diabetic SGLT2 inhibitors exert anti-aging effects?82
HMGB1, an evolving pleiotropic protein critical for cellular and tissue homeostasis: Role in aging and age-related diseases81
Characterization of the logopenic variant of Primary Progressive Aphasia: A systematic review and meta-analysis81
Melatonin: Potential avenue for treating iron overload disorders81
Modifiable lifestyle factors and cognitive reserve: A systematic review of current evidence80
Transcranial direct current stimulation combined with motor training for motor symptoms in Parkinson's disease: A systematic review and meta-analysis80
Searching for the link between inflammaging and sarcopenia80
New era of artificial intelligence and machine learning-based detection, diagnosis, and therapeutics in Parkinson’s disease79
Sensory nerve regulation of bone homeostasis: Emerging therapeutic opportunities for bone-related diseases79
Research progress in Alzheimer's disease and bone-brain axis78
Associations of olfactory function with brain structural and functional outcomes. A systematic review77
Targeting aging with urolithin A in humans: A systematic review77
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