Ageing Research Reviews

Papers
(The H4-Index of Ageing Research Reviews is 75. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-11-01 to 2025-11-01.)
ArticleCitations
Start the engine of neuroregeneration: A mechanistic and strategic overview of direct astrocyte-to-neuron reprogramming542
Editorial Board407
Adenosine metabolism and receptors in aging of the skin, musculoskeletal, immune and cardiovascular systems273
Roles of hypoxia-inducible factor-prolyl hydroxylases in aging and disease267
Microglia and gut microbiota: A double-edged sword in Alzheimer's disease262
Efficacy of technology-based cognitive and exercise interventions for mild cognitive impairment: A systematic review, network meta-analysis, and meta-regression of randomized controlled trials242
Advances in clinical application of lipidomics in healthy ageing and healthy longevity medicine232
Prevalence and health outcomes of polypharmacy and hyperpolypharmacy in older adults with frailty: A systematic review and meta-analysis224
Effectiveness of virtual reality interventions on quality of life, cognitive function and physical function in older people with Alzheimer's disease: A systematic review222
Can dementia risk be reduced by following the American Heart Association's Life's Simple 7? A systematic review and dose-response meta-analysis218
Artificial intelligence in brain MRI analysis of Alzheimer’s disease over the past 12 years: A systematic review211
Editorial Board194
Unravelling the brain resilience following stroke: From injury to rewiring of the brain through pathway activation, drug targets, and therapeutic interventions173
Unraveling the protein post-translational modification landscape: Neuroinflammation and neuronal death after stroke172
CC chemokines family in fibrosis and aging: From mechanisms to therapy168
Vascular cognitive impairment – Past, present, and future challenges167
The unique neuropathological vulnerability of the human brain to aging166
Dysfunction of norepinephrine and its metabolites in Alzheimer's dementia – A review with meta-analysis151
Discovery of a new hereditary RECQ helicase disorder RECON syndrome positions the replication stress response and genome homeostasis as centrally important processes in aging and age-related disease142
The functions of IRE1α in neurodegenerative diseases: Beyond ER stress142
Repetitive transcranial magnetic stimulation combined with cognitive training for cognitive function and activities of daily living in patients with post-stroke cognitive impairment: A systematic revi140
Thioredoxin-1 inhibits the activation of IRE1 by targeting Hsp90/p-Cdc37 chaperone complex in Parkinson disease132
Rethinking IRPs/IRE system in neurodegenerative disorders: Looking beyond iron metabolism131
Editorial Board128
Histopathological and ultrastructural changes in different cell types during ischemic and hemorrhagic stroke123
Advances in Alzheimer's therapy: Exploring neuropathological mechanisms to revolutionize the future therapeutic landscape121
Medication reviews in hospitalised patients for reduced hospital readmission and mortality. Systematic review, meta-analysis and meta-regression of RCTs119
Sarcobesity: New paradigms for healthy aging related to taurine supplementation, gut microbiota and exercise119
Type 2 diabetes mellitus augments Parkinson’s disease risk or the other way around: Facts, challenges and future possibilities118
DNA methylation in genes associated with the evolution of ageing and disease: A critical review118
Optimal dose and type of exercise to improve cognitive function in older adults: A systematic review and bayesian model-based network meta-analysis of RCTs117
How good is the evidence that cellular senescence causes skin ageing?116
Global, regional, and national burden of spinal cord injury from 1990 to 2021 and projections for 2050: A systematic analysis for the Global Burden of Disease 2021 study116
Does drug repurposing bridge the gaps in management of Parkinson’s disease? Unravelling the facts and fallacies115
Involvement of regulated cell deaths in aging and age-related pathologies111
Biomarkers associated with cognitive impairment in post-traumatic stress disorder: A systematic review of current evidence109
Transcranial direct current stimulation combined with motor training for motor symptoms in Parkinson's disease: A systematic review and meta-analysis108
Potential convergence of olfactory dysfunction in Parkinson’s disease and COVID-19: The role of neuroinflammation108
Targeting aging with urolithin A in humans: A systematic review108
Research progress in Alzheimer's disease and bone-brain axis105
Sensory nerve regulation of bone homeostasis: Emerging therapeutic opportunities for bone-related diseases103
Advances of artificial intelligence in predicting frailty using real-world data: A scoping review103
HMGB1, an evolving pleiotropic protein critical for cellular and tissue homeostasis: Role in aging and age-related diseases103
Role of diet and exercise in aging, Alzheimer’s disease, and other chronic diseases98
Searching for the link between inflammaging and sarcopenia98
Adherence to the Mediterranean diet and risk of frailty and pre-frailty in elderly adults: A systematic review and dose-response meta-analysis with GRADE assessment97
Characterization of the logopenic variant of Primary Progressive Aphasia: A systematic review and meta-analysis97
Cytosolic DNA sensor IFI16 proteins: Potential molecular integrators of interactions among the aging hallmarks96
Bridging neurotrophic factors and bioactive peptides to Alzheimer's disease95
On the wake of metformin: Do anti-diabetic SGLT2 inhibitors exert anti-aging effects?94
The several ways to authentically cure Alzheimer’s dementia93
The role of the PLA2G6 gene in neurodegenerative diseases92
Triaging between post-translational modification of cell cycle regulators and their therapeutics in neurodegenerative diseases92
Betaine and aging: A narrative review of findings, possible mechanisms, research perspectives, and practical recommendations90
Interventions to prevent and treat delirium: An umbrella review of randomized controlled trials90
Cognitive resilience in Alzheimer’s disease: Mechanism and potential clinical intervention90
The mitochondrial integrated stress response: A novel approach to anti-aging and pro-longevity89
Overview of pro-inflammatory and pro-survival components in neuroinflammatory signalling and neurodegeneration88
Hallmarks of aging: A user’s guide for comparative biologists88
The effectiveness of dance movement interventions for older adults with mild cognitive impairment, Alzheimer’s disease, and dementia: A systematic scoping review and meta-analysis87
New era of artificial intelligence and machine learning-based detection, diagnosis, and therapeutics in Parkinson’s disease83
The link between metabolic syndrome and Alzheimer disease: A mutual relationship and long rigorous investigation83
Associations of olfactory function with brain structural and functional outcomes. A systematic review82
Melatonin: Potential avenue for treating iron overload disorders82
Lipids and lipid metabolism in cellular senescence: Emerging targets for age-related diseases80
Modifiable lifestyle factors and cognitive reserve: A systematic review of current evidence80
Neuroprotection by agmatine: Possible involvement of the gut microbiome?80
Identification of exosomal biomarkers and its optimal isolation and detection method for the diagnosis of Parkinson's disease: A systematic review and meta-analysis79
Molecular hydrogen therapy: A “democratic” emerging strategy against aging and age-related diseases79
A Multimodal Meta-Analytical Evidence of Functional and Structural Brain Abnormalities Across Alzheimer's Disease Spectrum79
Latest developments of microphysiological systems (MPS) in aging-related and geriatric diseases research: A review78
Intracellular effects of lithium in aging neurons77
ADP-ribosylation, a multifaceted modification: Functions and mechanisms in aging and aging-related diseases76
The effect of ferroptosis-related mitochondrial dysfunction in the development of temporal lobe epilepsy75
The cross-talk between the cGAS-STING signaling pathway and chronic inflammation in the development of musculoskeletal disorders75
Association of frailty and pre-frailty with all-cause and cardiovascular mortality in diabetes: Three prospective cohorts and a meta-analysis75
Regulated cell death in acute myocardial infarction: Molecular mechanisms and therapeutic implications75
Biological constraint, evolutionary spandrels and antagonistic pleiotropy75
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