Ageing Research Reviews

Article	Citations
Start the engine of neuroregeneration: A mechanistic and strategic overview of direct astrocyte-to-neuron reprogramming	599
Editorial Board	286
The unique neuropathological vulnerability of the human brain to aging	278
The functions of IRE1α in neurodegenerative diseases: Beyond ER stress	250
Roles of hypoxia-inducible factor-prolyl hydroxylases in aging and disease	242
Rethinking IRPs/IRE system in neurodegenerative disorders: Looking beyond iron metabolism	239
Editorial Board	191
Advances in clinical application of lipidomics in healthy ageing and healthy longevity medicine	190
Medication reviews in hospitalised patients for reduced hospital readmission and mortality. Systematic review, meta-analysis and meta-regression of RCTs	190
HIV infection is associated with accelerated epigenetic ageing: A systematic review	185
Editor’s Note to “Biological constraint, evolutionary spandrels and antagonistic pleiotropy”	185
Type 2 diabetes mellitus augments Parkinson’s disease risk or the other way around: Facts, challenges and future possibilities	165
Histopathological and ultrastructural changes in different cell types during ischemic and hemorrhagic stroke	160
Sarcobesity: New paradigms for healthy aging related to taurine supplementation, gut microbiota and exercise	157
Thioredoxin-1 inhibits the activation of IRE1 by targeting Hsp90/p-Cdc37 chaperone complex in Parkinson disease	153
Unravelling the brain resilience following stroke: From injury to rewiring of the brain through pathway activation, drug targets, and therapeutic interventions	151
Dysfunction of norepinephrine and its metabolites in Alzheimer's dementia – A review with meta-analysis	150
Reevaluating principal component analysis in geroscience: A call for nonlinear approaches in AI-based evaluations	142
CC chemokines family in fibrosis and aging: From mechanisms to therapy	141
Microglia and gut microbiota: A double-edged sword in Alzheimer's disease	134
Ergothioneine and exercise: A match made in (cognitive) heaven?	132
Can dementia risk be reduced by following the American Heart Association's Life's Simple 7? A systematic review and dose-response meta-analysis	129
Efficacy of technology-based cognitive and exercise interventions for mild cognitive impairment: A systematic review, network meta-analysis, and meta-regression of randomized controlled trials	127
cGAS-STING-driven inflammaging cascade in aging-related retinal diseases: From pathological mechanism to therapeutic potentials	127
Cerebral glymphatic system: Structure, regulation, ageing, and mechanisms of encephalopathy	126

The past, present, and future of adipose tissue browning and aging: A review combined with bibliometrics and bioinformatics of 2527 documents published over the past four decades	125
Artificial intelligence in brain MRI analysis of Alzheimer’s disease over the past 12 years: A systematic review	124
Discovery of a new hereditary RECQ helicase disorder RECON syndrome positions the replication stress response and genome homeostasis as centrally important processes in aging and age-related disease	122
Does drug repurposing bridge the gaps in management of Parkinson’s disease? Unravelling the facts and fallacies	120
Global, regional, and national burden of spinal cord injury from 1990 to 2021 and projections for 2050: A systematic analysis for the Global Burden of Disease 2021 study	119
Glymphatic dysfunction in Parkinson's disease: Aging-associated impairments, imaging biomarkers, and therapeutic strategies	119
Prevalence and health outcomes of polypharmacy and hyperpolypharmacy in older adults with frailty: A systematic review and meta-analysis	116
Guardians of homeostasis: Natural products target metabolic reprogramming in Alzheimer’s disease	116
Optimal dose and type of exercise to improve cognitive function in older adults: A systematic review and bayesian model-based network meta-analysis of RCTs	112
Repetitive transcranial magnetic stimulation combined with cognitive training for cognitive function and activities of daily living in patients with post-stroke cognitive impairment: A systematic revi	112
Adenosine metabolism and receptors in aging of the skin, musculoskeletal, immune and cardiovascular systems	111
Unraveling the protein post-translational modification landscape: Neuroinflammation and neuronal death after stroke	110
Effectiveness of virtual reality interventions on quality of life, cognitive function and physical function in older people with Alzheimer's disease: A systematic review	109
Advances in Alzheimer's therapy: Exploring neuropathological mechanisms to revolutionize the future therapeutic landscape	108
Vascular cognitive impairment – Past, present, and future challenges	106
The mitochondrial integrated stress response: A novel approach to anti-aging and pro-longevity	105
Bridging neurotrophic factors and bioactive peptides to Alzheimer's disease	104
Hallmarks of aging: A user’s guide for comparative biologists	99
The role of the PLA2G6 gene in neurodegenerative diseases	99
The several ways to authentically cure Alzheimer’s dementia	98
Insulin resistance as a mediator of physical activity's effects on beta-amyloid accumulation and tau phosphorylation: A scoping review	98
The role of the gut microbiota in neuropsychiatric disorders and therapy	98
Potential convergence of olfactory dysfunction in Parkinson’s disease and COVID-19: The role of neuroinflammation	97
Neuroprotection by agmatine: Possible involvement of the gut microbiome?	96
Overview of pro-inflammatory and pro-survival components in neuroinflammatory signalling and neurodegeneration	94
Protein and peptide based nanotherapeutics for the management of Alzheimer’s disease: Current insights and future directions	94
Triaging between post-translational modification of cell cycle regulators and their therapeutics in neurodegenerative diseases	93
Role of diet and exercise in aging, Alzheimer’s disease, and other chronic diseases	91
Betaine and aging: A narrative review of findings, possible mechanisms, research perspectives, and practical recommendations	89
Identification of exosomal biomarkers and its optimal isolation and detection method for the diagnosis of Parkinson's disease: A systematic review and meta-analysis	88
Biomarkers associated with cognitive impairment in post-traumatic stress disorder: A systematic review of current evidence	88
Interventions to prevent and treat delirium: An umbrella review of randomized controlled trials	88
Advances of artificial intelligence in predicting frailty using real-world data: A scoping review	87
Cytosolic DNA sensor IFI16 proteins: Potential molecular integrators of interactions among the aging hallmarks	86
Unravelling the miscellaneous effects of exercise interventions on activities of daily living in frail older adults: A systematic review and meta-analysis	86
The effectiveness of dance movement interventions for older adults with mild cognitive impairment, Alzheimer’s disease, and dementia: A systematic scoping review and meta-analysis	84
Three-dimensional human brain organoids: A next-generation model to decode Alzheimer’s disease	84
Artificial intelligence for fall detection in older adults: A comprehensive survey of machine learning, deep learning approaches, and future directions	84
Involvement of regulated cell deaths in aging and age-related pathologies	83
On the wake of metformin: Do anti-diabetic SGLT2 inhibitors exert anti-aging effects?	82
Cognitive resilience in Alzheimer’s disease: Mechanism and potential clinical intervention	82
Adherence to the Mediterranean diet and risk of frailty and pre-frailty in elderly adults: A systematic review and dose-response meta-analysis with GRADE assessment	82
Melatonin: Potential avenue for treating iron overload disorders	81
HMGB1, an evolving pleiotropic protein critical for cellular and tissue homeostasis: Role in aging and age-related diseases	81
Characterization of the logopenic variant of Primary Progressive Aphasia: A systematic review and meta-analysis	81
Searching for the link between inflammaging and sarcopenia	80
Modifiable lifestyle factors and cognitive reserve: A systematic review of current evidence	80
Transcranial direct current stimulation combined with motor training for motor symptoms in Parkinson's disease: A systematic review and meta-analysis	80
New era of artificial intelligence and machine learning-based detection, diagnosis, and therapeutics in Parkinson’s disease	79
Sensory nerve regulation of bone homeostasis: Emerging therapeutic opportunities for bone-related diseases	79

Research progress in Alzheimer's disease and bone-brain axis	78
Associations of olfactory function with brain structural and functional outcomes. A systematic review	77
Targeting aging with urolithin A in humans: A systematic review	77
The link between metabolic syndrome and Alzheimer disease: A mutual relationship and long rigorous investigation	76
Lipids and lipid metabolism in cellular senescence: Emerging targets for age-related diseases	76
A Multimodal Meta-Analytical Evidence of Functional and Structural Brain Abnormalities Across Alzheimer's Disease Spectrum	76
Latest developments of microphysiological systems (MPS) in aging-related and geriatric diseases research: A review	76
The role of exercise in the prevention and treatment of Alzheimer’s disease and mild cognitive impairments	72
A novel regulator in Alzheimer's disease progression: The astrocyte-derived extracellular vesicles	71
Turquoise killifish: A natural model of age-dependent brain degeneration	71
Oral health indicators and bone mineral density disorders in older age: A systematic review	71
Molecular hydrogen therapy: A “democratic” emerging strategy against aging and age-related diseases	70
ADP-ribosylation, a multifaceted modification: Functions and mechanisms in aging and aging-related diseases	70
The cross-talk between the cGAS-STING signaling pathway and chronic inflammation in the development of musculoskeletal disorders	70
Advances in eye-brain axis: Anatomy, immunity, and association with visual dysfunction	69
The future of stem cell therapies of Alzheimer’s disease	69
Healthy brain aging and delayed dementia in Texas rural elderly	69
Long-term human spaceflight and inflammaging: Does it promote aging?	69
Expanding evolutionary theories of ageing to better account for symbioses and interactions throughout the Web of Life	69
Serotonin-mediated regulation of mitophagy in Alzheimer's disease: Mechanistic insights and therapeutic potential	68
The role of in silico and in vitro models in Parkinson’s disease: Drug discovery and therapy applications	68
Intracellular effects of lithium in aging neurons	67
Unravelling of molecular biomarkers in synaptic plasticity of Alzheimer’s disease: Critical role of the restoration of neuronal circuits	67
Beyond the Hayflick limit: How microbes influence cellular aging	67
Drug repositioning for Parkinson’s disease: An emphasis on artificial intelligence approaches	67
Association between pulse wave velocity and white matter hyperintensities among older adults: A meta-analysis of cross-sectional and longitudinal studies	67
A critical appraisal of blood-based biomarkers for Alzheimer’s disease	65
Aryl hydrocarbon receptor: From pathogenesis to therapeutic targets in aging-related tissue fibrosis	64
Frailty and the brain: A narrative review of functional and pathological correlates	64
Targeting the gut microbiota-related metabolites for osteoporosis: The inextricable connection of gut-bone axis	64
Suicide and dementia: A systematic review and meta-analysis of prevalence and risk factors	64
Under the umbrella of depression and Alzheimer’s disease physiopathology: Can cannabinoids be a dual-pleiotropic therapy?	64
The plasticity of fibroblasts: A forgotten player in the aging process	64
Modifiable risk factors for mild cognitive impairment among cognitively normal community-dwelling older adults: A systematic review and meta-analysis	63
Association of frailty and pre-frailty with all-cause and cardiovascular mortality in diabetes: Three prospective cohorts and a meta-analysis	62
Role of Nrf2 in aging, Alzheimer’s and other neurodegenerative diseases	62
Regulated cell death in acute myocardial infarction: Molecular mechanisms and therapeutic implications	62
Computerized cognitive training in Parkinson’s disease: A systematic review and meta-analysis	62
Targeting brain Renin-Angiotensin System for the prevention and treatment of Alzheimer’s disease: Past, present and future	61
Biological constraint, evolutionary spandrels and antagonistic pleiotropy	61
Modulators of ASIC1a and its potential as a therapeutic target for age-related diseases	61
Genetic mechanisms of aging in plants: What can we learn from them?	61
A tale of two systems: Lessons learned from female mid-life aging with implications for Alzheimer’s prevention & treatment	60
cGAS-STING targeting offers novel therapeutic opportunities in neurological diseases	60
The effect of ferroptosis-related mitochondrial dysfunction in the development of temporal lobe epilepsy	60
Editorial Board	60
The mechanisms of mitochondrial abnormalities that contribute to sleep disorders and related neurodegenerative diseases	60
Biomarkers of female reproductive aging in gerotherapeutic clinical trials	60
A review on neurodegeneration in the fast-ageing killifish, the first animal model to study the natural occurrence of neuronal cell loss	59
BACE1-dependent metabolism of neuregulin 1: Bridging the gap in explaining the occurrence of schizophrenia-like symptoms in Alzheimer's disease with psychosis?	58
The metabolic and endocrine impact of diet-derived gut microbiota metabolites on ageing and longevity	58
Is COVID-19 really a geriatric syndrome?	58
From onset to advancement: the temporal spectrum of α-synuclein in synucleinopathies	58
Resolution of inflammation, an active process to restore the immune microenvironment balance: A novel drug target for treating arterial hypertension	57
Telomere length and brain aging: A systematic review and meta-analysis	57
Underserved groups in dysphagia intervention trials in Parkinson’s disease: A scoping review	57
Association between lipocalin-2 and mild cognitive impairment or dementia: A systematic review and meta-analysis of population-based evidence	57
Restoration of epigenetic impairment in the skeletal muscle and chronic inflammation resolution as a therapeutic approach in sarcopenia	56
Hormesis defines the limits of lifespan	56
Recent advancement in understanding of Alzheimer's disease: Risk factors, subtypes, and drug targets and potential therapeutics	56
Unlocking the potential of histone deacetylase inhibitors in combatting age-related retinal degenerative diseases	56
Aryl hydrocarbon receptor (AhR) impairs circadian regulation: Impact on the aging process	56
Transposable elements and their role in aging	56
Mortality prediction models for community-dwelling older adults: A systematic review	56
Brain drug delivery and neurodegenerative diseases: Polymeric PLGA-based nanoparticles as a forefront platform	55
Alzheimer's disease and Alzheimer’s disease-related dementias in Hispanics: Identifying influential factors and supporting caregivers	55
Small molecule modulators of alpha-synuclein aggregation and toxicity: Pioneering an emerging arsenal against Parkinson’s disease	55
Neurobiology of depression in Parkinson’s disease: Insights into epidemiology, molecular mechanisms and treatment strategies	54
Editorial Board	54
The memory- and cognition-facilitating effects of spermidine in aging and aging-related disorders	54
Consolidating multiple evolutionary theories of ageing suggests a need for new approaches to study genetic contributions to ageing decline	54
Global burden, risk factors, and projections of early-onset dementia: Insights from the Global Burden of Disease Study 2021	54
Sirtuins in Parkinson's disease: Molecular mechanisms and pathophysiological roles	54
Antioxidants in anti‐Alzheimer's disease drug discovery	54
The mechanism of cuproptosis in Parkinson’s disease	54
Prevalence of psychotic symptoms in mild cognitive impairment: A systematic review and meta-analysis	54
Understanding age-related pathologic changes in TDP-43 functions and the consequence on RNA splicing and signalling in health and disease	53
Effect of ketogenic diets on insulin-like growth factor (IGF)-1 in humans: A systematic review and meta-analysis	53
Cerebellar pathology in forensic and clinical neuroscience	53
Epigenetic biomarkers in Alzheimer's disease: Diagnostic and prognostic relevance	52

Cerebral small vessel disease pathology in COVID-19 patients: A systematic review	52
Single-cell sequencing insights into the transcriptional landscape of Parkinson's disease	52
Associations between vision impairment and eye diseases with dementia, dementia subtypes and cognitive impairment: An umbrella review	52
The senotherapeutic potential of phytochemicals for age-related intestinal disease	52
FAM19A5 in vascular aging and osteoporosis: Mechanisms and the “calcification paradox”	51
Impact of exercise intervention-based changes on physical function biomarkers in older adults after hospital discharge: A systematic review with meta-analysis of randomized clinical trials	51
Blood pressure variability: A potential marker of aging	51
Impact of frailty on all-cause mortality or major amputation in patients with lower extremity peripheral artery disease: A meta-analysis	51
Multi-omics strategies to decode the molecular landscape of cellular senescence	51
Mitochondrial transfer between cell crosstalk – An emerging role in mitochondrial quality control	51
Liver X receptors and the hallmarks of aging: From molecular mechanisms to therapeutic opportunities	51
Biological resilience and aging: Activation of stress response pathways contributes to lifespan extension	50
Long-term fasting and its influence on inflammatory biomarkers: A comprehensive scoping review	50
The role of DEAD-box helicases in cardiovascular diseases	50
RNA binding proteins in senescence: A potential common linker for age-related diseases?	50
Modulating α-synuclein propagation and decomposition: Implications in Parkinson's disease therapy	49
Fractal dimension of the brain in neurodegenerative disease and dementia: A systematic review	49
Exploring Parkinson-associated kinases for CRISPR/Cas9-based gene editing: beyond alpha-synuclein	49
Efficacy of rehabilitation robot-assisted gait training on lower extremity dyskinesia in patients with Parkinson's disease: A systematic review and meta-analysis	48
Oxidative stress: The core pathogenesis and mechanism of Alzheimer’s disease	48
The role of nutrition in inflammaging	48
Heat stroke: Pathogenesis, diagnosis, and current treatment	48
Glial cells in Alzheimer’s disease: From neuropathological changes to therapeutic implications	48
Next-generation biosensor technologies for Alzheimer’s disease: Innovations in diagnosis, monitoring, and treatment	48
Prevalence of alcohol use among U.S. older adults with pain: A scoping review	47
Editorial Board	47
Editorial Board	47
Editorial Board	47
Resolving the current controversy of use and reuse of housekeeping proteins in ageing research: Focus on saving people’s tax dollars	46
The interplay of NAD and hypoxic stress and its relevance for ageing	46
Markers of biological age in dogs	46
Cannabidiol and neurodegeneration: From molecular mechanisms to clinical benefits	45
MSC-EVs alleviate osteoarthritis by regulating microenvironmental cells in the articular cavity and maintaining cartilage matrix homeostasis	45
The conceivable role of prolactin hormone in Parkinson disease: The same goal but with different ways	45
The prognostic impacts of frailty on clinical and patient-reported outcomes in patients undergoing coronary artery or valvular surgeries/procedures: A systematic review and meta-analysis	45
Adipose tissue and ovarian aging: Potential mechanism and protective strategies	45
Osteoporosis and Alzheimer´s disease (or Alzheimer´s disease and Osteoporosis)	45
A cross-talk between sestrins, chronic inflammation and cellular senescence governs the development of age-associated sarcopenia and obesity	44
Targeting impaired nutrient sensing via the sirtuin pathway with novel compounds to prevent or treat dementia: A systematic review	44
Is cognitive reserve associated with the prevention of cognitive decline after stroke? A Systematic review and meta-analysis	44
Neurobiological role and therapeutic potential of exercise-induced irisin in Alzheimer's disease management	44
Updates on brain regions and neuronal circuits of movement disorders in Parkinson’s disease	43
Effects of exercise interventions on cognitive functions in healthy populations: A systematic review and meta-analysis	43
Dementia, osteoporosis and fragility fractures: Intricate epidemiological relationships, plausible biological connections, and twisted clinical practices	43
Towards a comprehensive framework for complex walking tasks: Characterization, behavioral adaptations, and clinical implications in ageing and neurological populations	43
Deciphering the mechanistic impact of acupuncture on the neurovascular unit in acute ischemic stroke: Insights from basic research in a narrative review	42
Multi-omics research strategies in ischemic stroke: A multidimensional perspective	42
The role of oxidative stress in intervertebral disc degeneration: Mechanisms and therapeutic implications	42
Mechanosensitive Piezo1 channel in physiology and pathophysiology of the central nervous system	42
Pregnancy, preeclampsia and maternal aging: From epidemiology to functional genomics	41
Epigenetic clock: A promising biomarker and practical tool in aging	41
Osteosarcopenic adiposity (OSA) phenotype and its connection with cardiometabolic disorders: Is there a cause-and-effect?	41
Curcumin-loaded polymeric nanomaterials as a novel therapeutic strategy for Alzheimer's disease: A comprehensive review	40
Interlinked role of ASN, TDP-43 and Miro1 with parkinopathy: Focus on targeted approach against neuropathy in parkinsonism	40
Reducing Alzheimer’s disease risk with SGLT2 inhibitors: From glycemic control to neuroprotection	40
The role of serotonin within the microbiota-gut-brain axis in the development of Alzheimer’s disease: A narrative review	40
Therapeutic potential of lipid nanosystems for the treatment of Parkinson’s disease	40
Sarcopenia defined by the psoas muscle mass or quality is associated with poor survival in patients with aortic aneurysm undergoing surgery: A meta-analysis	39
Mendelian randomization analyses reveal relationships between white matter microstructure and risk of abdominal aortic aneurysm	39
Advances in human cellular mechanistic understanding and drug discovery of brain organoids for neurodegenerative diseases	39
Dose-response relationship of resistance training and the effects on circulating biomarkers of inflammation or neuroplasticity in older adults: A systematic review and meta-analysis	39
Precision neurology	39
Developing transcriptomic signatures as a biomarker of cellular senescence	39
Unknown roles of tau pathology in neurological disorders. Challenges and new perspectives	38
Emerging therapeutics agents and recent advances in drug repurposing for Alzheimer’s disease	38
Editorial Board	38
Editorial Board	38
Semaglutide as a possible therapy for healthy aging: Targeting the hallmarks of aging	38
Immersive virtual reality for older adults: Challenges and solutions in basic research and clinical applications	37
Target modulation of glycolytic pathways as a new strategy for the treatment of neuroinflammatory diseases	37
Priorities in tackling noncommunicable diseases among the population aged 60 years and older in China, 1990–2021: A population-based study	37
The hallmarks of aging in Ataxia-Telangiectasia	37
Is it time to revise the fighting strategy toward type 2 diabetes? Sex and pollution as new risk factors	37
Evolving landscape of colorectal cancer: Global and regional burden, risk factor dynamics, and future scenarios (the Global Burden of Disease 1990–2050)	37
Mapping the immune-genetic architecture of aging: A single-cell causal framework for biomarker discovery and therapeutic targeting	37
The association of living alone and social isolation with sarcopenia: A systematic review and meta-analysis	37
Definitions of healthspan: A systematic review	37
Macrophage membrane-camouflaged biomimetic nanovesicles for targeted treatment of arthritis	36
Motoric cognitive risk syndrome as a predictive factor of cognitive impairment and dementia – A systematic review and meta-analysis	36
Risk factors for multimorbidity in adulthood: A systematic review	36
Harnessing two-dimensional nanomaterials for diagnosis and therapy in neurodegenerative diseases: Advances, challenges and prospects	36
The oral organ: A new vision of the mouth as a whole for a gerophysiological approach to healthy aging	36
Immunometabolism and immune response regulate macrophage function in atherosclerosis	36
Pyroptosis: Mechanisms and links with diabetic cardiomyopathy	36
Rebalancing the unbalanced aged immune system – A special focus on zinc	36
Poly (ADP-ribose) polymerase 1 and neurodegenerative diseases: Past, present, and future	36
Progress in the mechanisms of pain associated with neurodegenerative diseases	35
Gut microbiome and Alzheimer’s disease: What we know and what remains to be explored	35
Reelin links Apolipoprotein E4, Tau, and Amyloid‐β in Alzheimer’s disease	35
Prevention of cardiovascular disease for healthy aging and longevity: A new scoring system and related “mechanisms-hallmarks-biomarkers”	35
Advancements in computer-assisted diagnosis of Alzheimer's disease: A comprehensive survey of neuroimaging methods and AI techniques for early detection	35
The social microbiome of older people	35
A systematic review of the effect and mechanism of Daoyin therapy on improving mild cognitive impairment in older adults	34
The therapeutic potential of adiponectin and extracellular vesicles for promoting improved healthspan	34
Past, present, and future of serotonin-targeting therapeutics for Alzheimer’s disease: Perspectives from DNA methylation	34