Ageing Research Reviews

Article	Citations
Editorial Board	477
Medication reviews in hospitalised patients for reduced hospital readmission and mortality. Systematic review, meta-analysis and meta-regression of RCTs	427
Does drug repurposing bridge the gaps in management of Parkinson’s disease? Unravelling the facts and fallacies	368
Editorial Board	244
Roles of hypoxia-inducible factor-prolyl hydroxylases in aging and disease	244
Discovery of a new hereditary RECQ helicase disorder RECON syndrome positions the replication stress response and genome homeostasis as centrally important processes in aging and age-related disease	241
The unique neuropathological vulnerability of the human brain to aging	238
miR-21 and miR-146a: The microRNAs of inflammaging and age-related diseases	226
Sarcobesity: New paradigms for healthy aging related to taurine supplementation, gut microbiota and exercise	211
Start the engine of neuroregeneration: A mechanistic and strategic overview of direct astrocyte-to-neuron reprogramming	207
Rethinking IRPs/IRE system in neurodegenerative disorders: Looking beyond iron metabolism	180
Editorial Board	172
The functions of IRE1α in neurodegenerative diseases: Beyond ER stress	169
Editor’s Note to “Biological constraint, evolutionary spandrels and antagonistic pleiotropy”	167
Type 2 diabetes mellitus augments Parkinson’s disease risk or the other way around: Facts, challenges and future possibilities	166
DNA methylation in genes associated with the evolution of ageing and disease: A critical review	157
Thioredoxin-1 inhibits the activation of IRE1 by targeting Hsp90/p-Cdc37 chaperone complex in Parkinson disease	155
Advances in clinical application of lipidomics in healthy ageing and healthy longevity medicine	152
CC chemokines family in fibrosis and aging: From mechanisms to therapy	151
Microglia and gut microbiota: A double-edged sword in Alzheimer's disease	149
Artificial intelligence in brain MRI analysis of Alzheimer’s disease over the past 12 years: A systematic review	148
How good is the evidence that cellular senescence causes skin ageing?	140
Adenosine metabolism and receptors in aging of the skin, musculoskeletal, immune and cardiovascular systems	140
Optimal dose and type of exercise to improve cognitive function in older adults: A systematic review and bayesian model-based network meta-analysis of RCTs	138
Advances in Alzheimer's therapy: Exploring neuropathological mechanisms to revolutionize the future therapeutic landscape	135

Effectiveness of virtual reality interventions on quality of life, cognitive function and physical function in older people with Alzheimer's disease: A systematic review	134
Repetitive transcranial magnetic stimulation combined with cognitive training for cognitive function and activities of daily living in patients with post-stroke cognitive impairment: A systematic revi	127
Unraveling the protein post-translational modification landscape: Neuroinflammation and neuronal death after stroke	123
Global, regional, and national burden of spinal cord injury from 1990 to 2021 and projections for 2050: A systematic analysis for the Global Burden of Disease 2021 study	119
Vascular cognitive impairment – Past, present, and future challenges	118
Updated systematic review and meta-analysis on diagnostic issues and the prognostic impact of myosteatosis: A new paradigm beyond sarcopenia	116
Prevalence and health outcomes of polypharmacy and hyperpolypharmacy in older adults with frailty: A systematic review and meta-analysis	115
Can dementia risk be reduced by following the American Heart Association's Life's Simple 7? A systematic review and dose-response meta-analysis	111
Unravelling the brain resilience following stroke: From injury to rewiring of the brain through pathway activation, drug targets, and therapeutic interventions	110
Efficacy of technology-based cognitive and exercise interventions for mild cognitive impairment: A systematic review, network meta-analysis, and meta-regression of randomized controlled trials	110
The protein inputs of an ultra-predictive aging clock represent viable anti-aging drug targets	109
Dysfunction of norepinephrine and its metabolites in Alzheimer's dementia – A review with meta-analysis	108
Biomarkers associated with cognitive impairment in post-traumatic stress disorder: A systematic review of current evidence	107
The several ways to authentically cure Alzheimer’s dementia	106
Interventions to prevent and treat delirium: An umbrella review of randomized controlled trials	106
Cognitive resilience in Alzheimer’s disease: Mechanism and potential clinical intervention	106
HMGB1, an evolving pleiotropic protein critical for cellular and tissue homeostasis: Role in aging and age-related diseases	105
Neuroprotection by agmatine: Possible involvement of the gut microbiome?	102
Advances of artificial intelligence in predicting frailty using real-world data: A scoping review	101
Targeting aging with urolithin A in humans: A systematic review	101
Overview of pro-inflammatory and pro-survival components in neuroinflammatory signalling and neurodegeneration	101
Associations of olfactory function with brain structural and functional outcomes. A systematic review	100
Involvement of regulated cell deaths in aging and age-related pathologies	99
Cytosolic DNA sensor IFI16 proteins: Potential molecular integrators of interactions among the aging hallmarks	96
Triaging between post-translational modification of cell cycle regulators and their therapeutics in neurodegenerative diseases	96
On the wake of metformin: Do anti-diabetic SGLT2 inhibitors exert anti-aging effects?	95
Role of diet and exercise in aging, Alzheimer’s disease, and other chronic diseases	95
Bridging neurotrophic factors and bioactive peptides to Alzheimer's disease	94
The mitochondrial integrated stress response: A novel approach to anti-aging and pro-longevity	92
Potential convergence of olfactory dysfunction in Parkinson’s disease and COVID-19: The role of neuroinflammation	90
Exercise training increases telomerase reverse transcriptase gene expression and telomerase activity: A systematic review and meta-analysis	87
Searching for the link between inflammaging and sarcopenia	86
Betaine and aging: A narrative review of findings, possible mechanisms, research perspectives, and practical recommendations	86
Melatonin: Potential avenue for treating iron overload disorders	85
Adherence to the Mediterranean diet and risk of frailty and pre-frailty in elderly adults: A systematic review and dose-response meta-analysis with GRADE assessment	84
Cross-sectional and longitudinal associations between adherence to Mediterranean diet with physical performance and cognitive function in older adults: A systematic review and meta-analysis	84
Sensory nerve regulation of bone homeostasis: Emerging therapeutic opportunities for bone-related diseases	84
Modifiable lifestyle factors and cognitive reserve: A systematic review of current evidence	82
The effectiveness of dance movement interventions for older adults with mild cognitive impairment, Alzheimer’s disease, and dementia: A systematic scoping review and meta-analysis	82
Characterization of the logopenic variant of Primary Progressive Aphasia: A systematic review and meta-analysis	81
Transcranial direct current stimulation combined with motor training for motor symptoms in Parkinson's disease: A systematic review and meta-analysis	80
The link between metabolic syndrome and Alzheimer disease: A mutual relationship and long rigorous investigation	80
Lipids and lipid metabolism in cellular senescence: Emerging targets for age-related diseases	78
The role of the PLA2G6 gene in neurodegenerative diseases	77
Targeting immune dysfunction in aging	77
Hallmarks of aging: A user’s guide for comparative biologists	77
Identification of exosomal biomarkers and its optimal isolation and detection method for the diagnosis of Parkinson's disease: A systematic review and meta-analysis	76
Omics sciences for systems biology in Alzheimer’s disease: State-of-the-art of the evidence	75
A Multimodal Meta-Analytical Evidence of Functional and Structural Brain Abnormalities Across Alzheimer's Disease Spectrum	75
Research progress in Alzheimer's disease and bone-brain axis	75

Genetic mechanisms of aging in plants: What can we learn from them?	74
New era of artificial intelligence and machine learning-based detection, diagnosis, and therapeutics in Parkinson’s disease	74
Latest developments of microphysiological systems (MPS) in aging-related and geriatric diseases research: A review	73
The effect of ferroptosis-related mitochondrial dysfunction in the development of temporal lobe epilepsy	73
Exercise interventions in Alzheimer’s disease: A systematic review and meta-analysis of randomized controlled trials	72
Affective symptoms and risk of progression to mild cognitive impairment or dementia in subjective cognitive decline: A systematic review and meta-analysis	72
Long-term human spaceflight and inflammaging: Does it promote aging?	72
Interactions between glial cells and the blood-brain barrier and their role in Alzheimer's disease	71
The cross-talk between the cGAS-STING signaling pathway and chronic inflammation in the development of musculoskeletal disorders	70
Intracellular effects of lithium in aging neurons	70
Beyond the Hayflick limit: How microbes influence cellular aging	70
A critical appraisal of blood-based biomarkers for Alzheimer’s disease	69
Unravelling of molecular biomarkers in synaptic plasticity of Alzheimer’s disease: Critical role of the restoration of neuronal circuits	67
The role of exercise in the prevention and treatment of Alzheimer’s disease and mild cognitive impairments	67
A novel regulator in Alzheimer's disease progression: The astrocyte-derived extracellular vesicles	67
Under the umbrella of depression and Alzheimer’s disease physiopathology: Can cannabinoids be a dual-pleiotropic therapy?	66
Biological constraint, evolutionary spandrels and antagonistic pleiotropy	66
Modifiable risk factors for mild cognitive impairment among cognitively normal community-dwelling older adults: A systematic review and meta-analysis	66
Oral health indicators and bone mineral density disorders in older age: A systematic review	66
The plasticity of fibroblasts: A forgotten player in the aging process	66
cGAS-STING targeting offers novel therapeutic opportunities in neurological diseases	65
Suicide and dementia: A systematic review and meta-analysis of prevalence and risk factors	65
ADP-ribosylation, a multifaceted modification: Functions and mechanisms in aging and aging-related diseases	65
Association of frailty and pre-frailty with all-cause and cardiovascular mortality in diabetes: Three prospective cohorts and a meta-analysis	64
Molecular hydrogen therapy: A “democratic” emerging strategy against aging and age-related diseases	64
Healthy brain aging and delayed dementia in Texas rural elderly	64
Modulators of ASIC1a and its potential as a therapeutic target for age-related diseases	63
Drug repositioning for Parkinson’s disease: An emphasis on artificial intelligence approaches	63
Expanding evolutionary theories of ageing to better account for symbioses and interactions throughout the Web of Life	63
Turquoise killifish: A natural model of age-dependent brain degeneration	63
Aryl hydrocarbon receptor: From pathogenesis to therapeutic targets in aging-related tissue fibrosis	62
Regulated cell death in acute myocardial infarction: Molecular mechanisms and therapeutic implications	62
Dissecting primary and secondary senescence to enable new senotherapeutic strategies	61
Unsupervised home-based resistance training for community-dwelling older adults: A systematic review and meta-analysis of randomized controlled trials	61
Targeting brain Renin-Angiotensin System for the prevention and treatment of Alzheimer’s disease: Past, present and future	61
Targeting the gut microbiota-related metabolites for osteoporosis: The inextricable connection of gut-bone axis	61
Computerized cognitive training in Parkinson’s disease: A systematic review and meta-analysis	60
Role of Nrf2 in aging, Alzheimer’s and other neurodegenerative diseases	60
Association between pulse wave velocity and white matter hyperintensities among older adults: A meta-analysis of cross-sectional and longitudinal studies	60
Editorial Board	59
The future of stem cell therapies of Alzheimer’s disease	59
Is COVID-19 really a geriatric syndrome?	59
Current research status of blood biomarkers in Alzheimer’s disease: Diagnosis and prognosis	59
Consolidating multiple evolutionary theories of ageing suggests a need for new approaches to study genetic contributions to ageing decline	59
Antioxidants in anti‐Alzheimer's disease drug discovery	58
Alzheimer's disease and Alzheimer’s disease-related dementias in Hispanics: Identifying influential factors and supporting caregivers	58
Underserved groups in dysphagia intervention trials in Parkinson’s disease: A scoping review	58
Association between lipocalin-2 and mild cognitive impairment or dementia: A systematic review and meta-analysis of population-based evidence	58
Telomere length and brain aging: A systematic review and meta-analysis	58
From corpora amylacea to wasteosomes: History and perspectives	57
Resolution of inflammation, an active process to restore the immune microenvironment balance: A novel drug target for treating arterial hypertension	56
BACE1-dependent metabolism of neuregulin 1: Bridging the gap in explaining the occurrence of schizophrenia-like symptoms in Alzheimer's disease with psychosis?	56
The metabolic and endocrine impact of diet-derived gut microbiota metabolites on ageing and longevity	56
Mortality prediction models for community-dwelling older adults: A systematic review	56
Unlocking the potential of histone deacetylase inhibitors in combatting age-related retinal degenerative diseases	55
From onset to advancement: the temporal spectrum of α-synuclein in synucleinopathies	55
Small molecule modulators of alpha-synuclein aggregation and toxicity: Pioneering an emerging arsenal against Parkinson’s disease	55
A review on neurodegeneration in the fast-ageing killifish, the first animal model to study the natural occurrence of neuronal cell loss	55
Global burden, risk factors, and projections of early-onset dementia: Insights from the Global Burden of Disease Study 2021	54
A tale of two systems: Lessons learned from female mid-life aging with implications for Alzheimer’s prevention & treatment	54
Aryl hydrocarbon receptor (AhR) impairs circadian regulation: Impact on the aging process	54
The memory- and cognition-facilitating effects of spermidine in aging and aging-related disorders	54
The mechanism of cuproptosis in Parkinson’s disease	53
Neurobiology of depression in Parkinson’s disease: Insights into epidemiology, molecular mechanisms and treatment strategies	53
Brain drug delivery and neurodegenerative diseases: Polymeric PLGA-based nanoparticles as a forefront platform	53
Recent advancement in understanding of Alzheimer's disease: Risk factors, subtypes, and drug targets and potential therapeutics	53
Restoration of epigenetic impairment in the skeletal muscle and chronic inflammation resolution as a therapeutic approach in sarcopenia	53
Transposable elements and their role in aging	53
The mechanisms of mitochondrial abnormalities that contribute to sleep disorders and related neurodegenerative diseases	53
Editorial Board	52
Hormesis defines the limits of lifespan	52
Epigenetic biomarkers in Alzheimer's disease: Diagnostic and prognostic relevance	51
Fractal dimension of the brain in neurodegenerative disease and dementia: A systematic review	51
Heat stroke: Pathogenesis, diagnosis, and current treatment	50
Single-cell sequencing insights into the transcriptional landscape of Parkinson's disease	50
Understanding age-related pathologic changes in TDP-43 functions and the consequence on RNA splicing and signalling in health and disease	50
Cerebellar pathology in forensic and clinical neuroscience	50
Modulating α-synuclein propagation and decomposition: Implications in Parkinson's disease therapy	49
Effect of ketogenic diets on insulin-like growth factor (IGF)-1 in humans: A systematic review and meta-analysis	49
RNA binding proteins in senescence: A potential common linker for age-related diseases?	49

Impact of exercise intervention-based changes on physical function biomarkers in older adults after hospital discharge: A systematic review with meta-analysis of randomized clinical trials	49
Cerebral small vessel disease pathology in COVID-19 patients: A systematic review	49
FAM19A5 in vascular aging and osteoporosis: Mechanisms and the “calcification paradox”	49
Breakdown of specific functional brain networks in clinical variants of Alzheimer’s disease	49
Exploring Parkinson-associated kinases for CRISPR/Cas9-based gene editing: beyond alpha-synuclein	49
Efficacy of rehabilitation robot-assisted gait training on lower extremity dyskinesia in patients with Parkinson's disease: A systematic review and meta-analysis	49
Impact of frailty on all-cause mortality or major amputation in patients with lower extremity peripheral artery disease: A meta-analysis	49
Long-term fasting and its influence on inflammatory biomarkers: A comprehensive scoping review	49
The senotherapeutic potential of phytochemicals for age-related intestinal disease	48
Glial cells in Alzheimer’s disease: From neuropathological changes to therapeutic implications	48
Retinal biomarkers in Alzheimer’s disease and mild cognitive impairment: A systematic review and meta-analysis	48
Blood pressure variability: A potential marker of aging	48
The role of nutrition in inflammaging	47
Associations between vision impairment and eye diseases with dementia, dementia subtypes and cognitive impairment: An umbrella review	47
Prevalence of psychotic symptoms in mild cognitive impairment: A systematic review and meta-analysis	47
Oxidative stress: The core pathogenesis and mechanism of Alzheimer’s disease	47
Widowhood and cognitive decline in adults aged 50 and over: A systematic review and meta-analysis	46
Mitochondrial transfer between cell crosstalk – An emerging role in mitochondrial quality control	46
Biological resilience and aging: Activation of stress response pathways contributes to lifespan extension	46
The interplay of NAD and hypoxic stress and its relevance for ageing	45
Editorial Board	45
Editorial Board	45
Resolving the current controversy of use and reuse of housekeeping proteins in ageing research: Focus on saving people’s tax dollars	45
Editorial Board	45
The prognostic impacts of frailty on clinical and patient-reported outcomes in patients undergoing coronary artery or valvular surgeries/procedures: A systematic review and meta-analysis	44
Prevalence of alcohol use among U.S. older adults with pain: A scoping review	44
The role of serotonin within the microbiota-gut-brain axis in the development of Alzheimer’s disease: A narrative review	44
Cannabidiol and neurodegeneration: From molecular mechanisms to clinical benefits	44
Deciphering the mechanistic impact of acupuncture on the neurovascular unit in acute ischemic stroke: Insights from basic research in a narrative review	44
Pregnancy, preeclampsia and maternal aging: From epidemiology to functional genomics	44
Is cognitive reserve associated with the prevention of cognitive decline after stroke? A Systematic review and meta-analysis	43
Targeting impaired nutrient sensing via the sirtuin pathway with novel compounds to prevent or treat dementia: A systematic review	43
Towards a comprehensive framework for complex walking tasks: Characterization, behavioral adaptations, and clinical implications in ageing and neurological populations	43
Osteosarcopenic adiposity (OSA) phenotype and its connection with cardiometabolic disorders: Is there a cause-and-effect?	43
Adipose tissue and ovarian aging: Potential mechanism and protective strategies	43
The conceivable role of prolactin hormone in Parkinson disease: The same goal but with different ways	42
Neurobiological role and therapeutic potential of exercise-induced irisin in Alzheimer's disease management	42
Mechanosensitive Piezo1 channel in physiology and pathophysiology of the central nervous system	42
The Role of Rapamycin in Healthspan Extension via the Delay of Organ Aging	42
Multi-omics research strategies in ischemic stroke: A multidimensional perspective	42
Osteoporosis and Alzheimer´s disease (or Alzheimer´s disease and Osteoporosis)	42
A cross-talk between sestrins, chronic inflammation and cellular senescence governs the development of age-associated sarcopenia and obesity	42
Epigenetic clock: A promising biomarker and practical tool in aging	42
Updates on brain regions and neuronal circuits of movement disorders in Parkinson’s disease	42
Reply to “Caution in underrepresentation of older adults in clinical trials on COVID-19 vaccines”	41
Precision neurology	41
Effects of exercise interventions on cognitive functions in healthy populations: A systematic review and meta-analysis	41
The role of oxidative stress in intervertebral disc degeneration: Mechanisms and therapeutic implications	41
Dementia, osteoporosis and fragility fractures: Intricate epidemiological relationships, plausible biological connections, and twisted clinical practices	41
MSC-EVs alleviate osteoarthritis by regulating microenvironmental cells in the articular cavity and maintaining cartilage matrix homeostasis	41
Editorial Board	41
Therapeutic potential of lipid nanosystems for the treatment of Parkinson’s disease	40
Is it time to revise the fighting strategy toward type 2 diabetes? Sex and pollution as new risk factors	40
The impact of aging on HIV-1-related neurocognitive impairment	40
Priorities in tackling noncommunicable diseases among the population aged 60 years and older in China, 1990–2021: A population-based study	40
Unknown roles of tau pathology in neurological disorders. Challenges and new perspectives	40
Emerging therapeutics agents and recent advances in drug repurposing for Alzheimer’s disease	39
Reducing Alzheimer’s disease risk with SGLT2 inhibitors: From glycemic control to neuroprotection	39
Progress in the mechanisms of pain associated with neurodegenerative diseases	39
Editorial Board	39
Semaglutide as a possible therapy for healthy aging: Targeting the hallmarks of aging	39
Developing transcriptomic signatures as a biomarker of cellular senescence	38
Harnessing two-dimensional nanomaterials for diagnosis and therapy in neurodegenerative diseases: Advances, challenges and prospects	38
Prevention of cardiovascular disease for healthy aging and longevity: A new scoring system and related “mechanisms-hallmarks-biomarkers”	38
Exerkines: Potential regulators of diabetic cardiomyopathy	38
Advances in human cellular mechanistic understanding and drug discovery of brain organoids for neurodegenerative diseases	38
Rebalancing the unbalanced aged immune system – A special focus on zinc	38
Interlinked role of ASN, TDP-43 and Miro1 with parkinopathy: Focus on targeted approach against neuropathy in parkinsonism	38
Sarcopenia defined by the psoas muscle mass or quality is associated with poor survival in patients with aortic aneurysm undergoing surgery: A meta-analysis	38
Evolving landscape of colorectal cancer: Global and regional burden, risk factor dynamics, and future scenarios (the Global Burden of Disease 1990–2050)	37
Macrophage membrane-camouflaged biomimetic nanovesicles for targeted treatment of arthritis	37
Motoric cognitive risk syndrome as a predictive factor of cognitive impairment and dementia – A systematic review and meta-analysis	37
Role of UCHL1 in the pathogenesis of neurodegenerative diseases and brain injury	37
Gut microbiome and Alzheimer’s disease: What we know and what remains to be explored	37
Target modulation of glycolytic pathways as a new strategy for the treatment of neuroinflammatory diseases	37
The oral organ: A new vision of the mouth as a whole for a gerophysiological approach to healthy aging	37
Curcumin-loaded polymeric nanomaterials as a novel therapeutic strategy for Alzheimer's disease: A comprehensive review	37
Exploring cytokines dynamics: Uncovering therapeutic concepts for metabolic disorders in postmenopausal women- diabetes, metabolic bone diseases, and non-alcohol fatty liver disease	37
The hallmarks of aging in Ataxia-Telangiectasia	36
Modulating the polarization phenotype of microglia – A valuable strategy for central nervous system diseases	36
Immersive virtual reality for older adults: Challenges and solutions in basic research and clinical applications	36
Immunometabolism and immune response regulate macrophage function in atherosclerosis	36
The association of living alone and social isolation with sarcopenia: A systematic review and meta-analysis	36
Poly (ADP-ribose) polymerase 1 and neurodegenerative diseases: Past, present, and future	36
Risk factors for multimorbidity in adulthood: A systematic review	35
Reelin links Apolipoprotein E4, Tau, and Amyloid‐β in Alzheimer’s disease	35
Pyroptosis: Mechanisms and links with diabetic cardiomyopathy	35
Circadian regulation of microglia function: Potential targets for treatment of Parkinson’s Disease	34
Cognition on the move: Examining the role of physical exercise and neurogenesis in counteracting cognitive aging	34
Implicative role of cytokines in neuroinflammation mediated AD and associated signaling pathways: Current progress in molecular signaling and therapeutics	34
Editorial Board	34
Past, present, and future of serotonin-targeting therapeutics for Alzheimer’s disease: Perspectives from DNA methylation	34
Epithelial-mesenchymal transition in age-associated thymic involution: Mechanisms and therapeutic implications	34
Advancements in computer-assisted diagnosis of Alzheimer's disease: A comprehensive survey of neuroimaging methods and AI techniques for early detection	34
Unraveling the mystery of citrate transporters in Alzheimer’s disease: An updated review	34