Ageing Research Reviews

Article	Citations
Editorial Board	382
Does drug repurposing bridge the gaps in management of Parkinson’s disease? Unravelling the facts and fallacies	366
Comparison between frail and non-frail older adults’ gut microbiota: A systematic review and meta-analysis	317
Targeted microbiota dysbiosis repair: An important approach to health management after spinal cord injury	273
Medication reviews in hospitalised patients for reduced hospital readmission and mortality. Systematic review, meta-analysis and meta-regression of RCTs	219
Metabolic dysfunction contributes to mood disorders after traumatic brain injury	213
Adenosine metabolism and receptors in aging of the skin, musculoskeletal, immune and cardiovascular systems	210
From text to insight: A natural language processing-based analysis of burst and research trends in HER2-low breast cancer patients	208
Curcumin-loaded polymeric nanomaterials as a novel therapeutic strategy for Alzheimer's disease: A comprehensive review	202
Exploring the conceptual framework and measurement model of intrinsic capacity defined by the World Health Organization: A scoping review	185
Curcumin nanoformulations to combat aging-related diseases	181
From biological aging to functional decline: Insights into chronic inflammation and intrinsic capacity	178
Adult-onset hearing loss and incident cognitive impairment and dementia – A systematic review and meta-analysis of cohort studies	166
Biomarkers used in Alzheimer’s disease diagnosis, treatment, and prevention	164
The roles of the Hippo-YAP signalling pathway in Cartilage and Osteoarthritis	163
Modulation of cholesterol metabolism with Phytoremedies in Alzheimer’s disease: A comprehensive review	141
Neuroenergetic alterations in neurodegenerative diseases: A systematic review and meta-analysis of in vivo 31P-MRS studies	141
Lactylation modification in cardio-cerebral diseases: A state-of-the-art review	139
Precision neurology	134
Inflammatory signaling pathways in Alzheimer's disease: Mechanistic insights and possible therapeutic interventions	133
Type 2 diabetes mellitus augments Parkinson’s disease risk or the other way around: Facts, challenges and future possibilities	133
Bridging geriatric medicine, clinical pharmacology and ageing biology to understand and improve outcomes of medicines in old age and frailty	129
DNA methylation in genes associated with the evolution of ageing and disease: A critical review	127
Psychometric characteristics of comprehensive geriatric assessments (CGAs) for long-term care facilities and community care: A systematic review	126
Editorial Board	126

Editorial Board	126
Editorial Board	124
Editorial Board	120
Pyroptosis: Mechanisms and links with diabetic cardiomyopathy	118
Editorial Board	118
Association of F2-isoprostane levels with Alzheimer’s disease in observational studies: A systematic review and meta-analysis	117
Editorial Board	116
Editorial Board	110
Reply to “Caution in underrepresentation of older adults in clinical trials on COVID-19 vaccines”	108
Determining the cortical, spinal and muscular adaptations to strength-training in older adults: A systematic review and meta-analysis	107
COVID-19 mortality as a fingerprint of biological age	105
The protein inputs of an ultra-predictive aging clock represent viable anti-aging drug targets	104
Sex difference, proteostasis and mitochondrial function impact stroke-related sarcopenia—A systematic review and meta-analysis	103
Pangenomics: A new era in the field of neurodegenerative diseases	97
Lifestyle strategies to promote proteostasis and reduce the risk of Alzheimer’s disease and other proteinopathies	96
Sarcopenia defined by the psoas muscle mass or quality is associated with poor survival in patients with aortic aneurysm undergoing surgery: A meta-analysis	95
Reelin links Apolipoprotein E4, Tau, and Amyloid‐β in Alzheimer’s disease	95
Restoring the oxidative balance in age-related diseases – An approach in glaucoma	94
Constituent isoflavones of Puerariae radix as a potential neuroprotector in cognitive impairment: Evidence from preclinical studies	94
Research progress on the effects of novel hypoglycemic drugs in diabetes combined with myocardial ischemia/reperfusion injury	93
Genetic aberration analysis of mitochondrial respiratory complex I implications in the development of neurological disorders and their clinical significance	92
Gut microbiome and Alzheimer’s disease: What we know and what remains to be explored	92
The functions of IRE1α in neurodegenerative diseases: Beyond ER stress	91
Neolignans in Magnolia officinalis as natural anti-Alzheimer’s disease agents: A systematic review	90
To breathe or not to breathe: Understanding how oxygen sensing contributes to age-related phenotypes	90
Beyond cardiovascular risk: Implications of Familial hypercholesterolemia on cognition and brain function	88
Risk of seizures and subclinical epileptiform activity in patients with dementia: A systematic review and meta-analysis	87
The retina: A window in which to view the pathogenesis of Alzheimer’s disease	87
Emerging therapeutics agents and recent advances in drug repurposing for Alzheimer’s disease	85
Immunity orchestrates a bridge in gut-brain axis of neurodegenerative diseases	82
Mechanism and therapeutic targets of the involvement of a novel lysosomal proton channel TMEM175 in Parkinson's disease	82
Frailty in rodents: Models, underlying mechanisms, and management	82
Frailty and pain, human studies and animal models	82
Energy metabolism and frailty: The potential role of exercise-induced myokines – A narrative review	81
Therapeutic potential of lipid nanosystems for the treatment of Parkinson’s disease	80
The unique neuropathological vulnerability of the human brain to aging	80
Bio-enhanced fraction from Clitoria ternatea root extract ameliorates cognitive functions and in vivo hippocampal neuroplasticity in chronic cerebral hypoperfusion rat model	80
Universal masking during COVID-19 outbreaks in aged care settings: A systematic review and meta-analysis	79
Psychedelics for alzheimer's disease-related dementia: Unveiling therapeutic possibilities and pathways	79
Calprotectin in Parkinsonian disease: Anticipation and dedication	78
Development of nanomedicines for the treatment of Alzheimer’s disease: Raison d’être, strategies, challenges and regulatory aspects	76
Spatial omics: An innovative frontier in aging research	76
Is it time to revise the fighting strategy toward type 2 diabetes? Sex and pollution as new risk factors	75
The underlying roles and neurobiological mechanisms of music-based intervention in Alzheimer's disease: A comprehensive review	74
Prevalence of radicular neuropathic pain in idiopathic Parkinson’s disease: A systematic review and meta-analysis	73
Advances in clinical application of lipidomics in healthy ageing and healthy longevity medicine	71
Target modulation of glycolytic pathways as a new strategy for the treatment of neuroinflammatory diseases	69
Advancing the understanding of diabetic encephalopathy through unravelling pathogenesis and exploring future treatment perspectives	68
The impact of aging on HIV-1-related neurocognitive impairment	68
Breaking new ground on human health and well-being with epigenetic clocks: A systematic review and meta-analysis of epigenetic age acceleration associations	68

Sarcobesity: New paradigms for healthy aging related to taurine supplementation, gut microbiota and exercise	68
Exercise-induced adaptive response of different immune organs during ageing	68
Does personality affect the cognitive decline in aging? A systematic review	68
Regulation of DNA damage response by RNA/DNA-binding proteins: Implications for neurological disorders and aging	68
Obesity-induced neuronal senescence: Unraveling the pathophysiological links	67
The emerging role of exercise in Alzheimer’s disease: Focus on mitochondrial function	67
Semaglutide as a possible therapy for healthy aging: Targeting the hallmarks of aging	67
The functions and regulation of Otubains in protein homeostasis and diseases	66
Effects of interventions on cerebral perfusion in the Alzheimer's disease spectrum: A systematic review	66
Sarcopenia in trauma patients: A systematic review and meta-analysis	66
MicroRNAs in the regulation of autophagy and their possible use in age-related macular degeneration therapy	66
Improving geriatric outcomes through nutritional and immunonutritional strategies: Focus on surgical setting by a comprehensive evidence review	65
Pasteurized non-fermented cow’s milk but not fermented milk is a promoter of mTORC1-driven aging and increased mortality	64
Interspecific interactions that affect ageing: Age-distorters manipulate host ageing to their own evolutionary benefits	64
Relationship between obesity and structural brain abnormality: Accumulated evidence from observational studies	63
p62 works as a hub modulation in the ageing process	63
Repetitive transcranial magnetic stimulation combined with cognitive training for cognitive function and activities of daily living in patients with post-stroke cognitive impairment: A systematic revi	62
Can extracellular vesicles be considered as a potential frontier in the treatment of intervertebral disc disease?	62
Interlinked role of ASN, TDP-43 and Miro1 with parkinopathy: Focus on targeted approach against neuropathy in parkinsonism	62
Discovery of a new hereditary RECQ helicase disorder RECON syndrome positions the replication stress response and genome homeostasis as centrally important processes in aging and age-related disease	62
Global, regional, and national burden of spinal cord injury from 1990 to 2021 and projections for 2050: A systematic analysis for the Global Burden of Disease 2021 study	61
Innovative approaches to Alzheimer's therapy: Harnessing the power of heterocycles, oxidative stress management, and nanomaterial drug delivery system	60
Thioredoxin-1 inhibits the activation of IRE1 by targeting Hsp90/p-Cdc37 chaperone complex in Parkinson disease	60
Rebalancing the unbalanced aged immune system – A special focus on zinc	60
Principles of brain aging: Status and challenges of modeling human molecular changes in mice	59
The hallmarks of aging in Ataxia-Telangiectasia	58
The classical and non-classical axes of renin-angiotensin system in Parkinson disease: The bright and dark side of the moon	57
Mitochondria break free: Mitochondria-derived vesicles in aging and associated conditions	56
Priorities in tackling noncommunicable diseases among the population aged 60 years and older in China, 1990–2021: A population-based study	55
Editorial Board	55
Mesencephalic astrocyte-derived neurotrophic factor (MANF): Structure, functions and therapeutic potential	55
Progress in the mechanisms of pain associated with neurodegenerative diseases	55
Unknown roles of tau pathology in neurological disorders. Challenges and new perspectives	55
Roles of hypoxia-inducible factor-prolyl hydroxylases in aging and disease	55
Editorial Board	55
Vascular dementia: A microglia's perspective	54
Harnessing two-dimensional nanomaterials for diagnosis and therapy in neurodegenerative diseases: Advances, challenges and prospects	54
Apathy in Alzheimer’s disease: A neurocircuitry based perspective	54
Associations between social health factors, cognitive activity and neurostructural markers for brain health – A systematic literature review and meta-analysis	54
Redox imbalance in age-related ovarian dysfunction and perspectives for its prevention	54
Unveiling the role of astrocytes in postoperative cognitive dysfunction	54
Transcranial magnetic stimulation (TMS) for geriatric depression	54
A review of dementia, focusing on the distinct roles of viral protein corona and MMP9 in dementia: Potential pharmacotherapeutic priorities	53
Balance-based exercise programs on balance in older adults with mild to moderate dementia: A critically appraised topic	53
Beta-adrenergic drugs and risk of Parkinson’s disease: A systematic review and meta-analysis	53
Macrophage membrane-camouflaged biomimetic nanovesicles for targeted treatment of arthritis	53
Passive Alzheimer’s immunotherapy: A promising or uncertain option?	52
Poly (ADP-ribose) polymerase 1 and neurodegenerative diseases: Past, present, and future	52
Immunometabolism and immune response regulate macrophage function in atherosclerosis	52
Evolving therapeutic interventions for the management and treatment of Alzheimer’s disease	51
Efficacy of technology-based cognitive and exercise interventions for mild cognitive impairment: A systematic review, network meta-analysis, and meta-regression of randomized controlled trials	51
Conserved Biological Processes in Partial Cellular Reprogramming: Relevance to Aging and Rejuvenation	51
Role of enteric glia and microbiota-gut-brain axis in parkinson disease pathogenesis	51
Sex biology in amyotrophic lateral sclerosis	51
CXCL12/CXCR4: An amazing challenge and opportunity in the fight against fibrosis	50
Evolving landscape of colorectal cancer: Global and regional burden, risk factor dynamics, and future scenarios (the Global Burden of Disease 1990–2050)	50
Risk factors for multimorbidity in adulthood: A systematic review	50
Prevalence and health outcomes of polypharmacy and hyperpolypharmacy in older adults with frailty: A systematic review and meta-analysis	50
Sirtuins, resveratrol and the intertwining cellular pathways connecting them	50
Modulating the polarization phenotype of microglia – A valuable strategy for central nervous system diseases	49
Passive immunotherapy for Alzheimer's disease	49
Tau internalization: A complex step in tau propagation	48
The oral organ: A new vision of the mouth as a whole for a gerophysiological approach to healthy aging	48
The accelerated aging phenotype: The role of race and social determinants of health on aging	47
Prediction models for depression risk among older adults: systematic review and critical appraisal	47
A new face of old cells: An overview about the role of senescence and telomeres in inflammatory bowel diseases	47
Structural and physiological changes of the kidney with age and its impact on chronic conditions and COVID-19	47
Microglia and gut microbiota: A double-edged sword in Alzheimer's disease	47
The association of living alone and social isolation with sarcopenia: A systematic review and meta-analysis	46
Exploring cytokines dynamics: Uncovering therapeutic concepts for metabolic disorders in postmenopausal women- diabetes, metabolic bone diseases, and non-alcohol fatty liver disease	46
Types of exercise and training duration on depressive symptoms among older adults in long-term care facilities	46
Pharmaceutical and nutraceutical activation of FOXO3 for healthy longevity	46
Is personality associated with dementia risk? A meta-analytic investigation	46
Quercetin-functionalized nanomaterials: Innovative therapeutic avenues for Alzheimer's disease management	45
Motoric cognitive risk syndrome as a predictive factor of cognitive impairment and dementia – A systematic review and meta-analysis	45
Short-chain fatty acid metabolism and multiple effects on cardiovascular diseases	45
Autophagy in aging-related diseases and cancer: Principles, regulatory mechanisms and therapeutic potential	45
Updated systematic review and meta-analysis on diagnostic issues and the prognostic impact of myosteatosis: A new paradigm beyond sarcopenia	45
Oxidative stress and antioxidant defenses in mild cognitive impairment: A systematic review and meta-analysis	44
Determinants of approved acetylcholinesterase inhibitor response outcomes in Alzheimer’s disease: relevance for precision medicine in neurodegenerative diseases	44

Deregulated mitochondrial microRNAs in Alzheimer's disease: Focus on synapse and mitochondria	44
Unraveling the protein post-translational modification landscape: Neuroinflammation and neuronal death after stroke	44
CC chemokines family in fibrosis and aging: From mechanisms to therapy	44
Socially assistive robots for people with dementia: Systematic review and meta-analysis of feasibility, acceptability and the effect on cognition, neuropsychiatric symptoms and quality of life	43
Role of UCHL1 in the pathogenesis of neurodegenerative diseases and brain injury	43
Research progress in the molecular mechanism of ferroptosis in Parkinson's disease and regulation by natural plant products	43
Novel fluid biomarkers for mild cognitive impairment: A systematic review and meta-analysis	43
Multiomics insights into the female reproductive aging	42
How good is the evidence that cellular senescence causes skin ageing?	42
Ageing, proteostasis, and the gut: Insights into neurological health and disease	42
Inflammatory pathways in Alzheimer’s disease mediated by gut microbiota	42
Artificial intelligence in brain MRI analysis of Alzheimer’s disease over the past 12 years: A systematic review	42
Potential mechanisms underlying the accelerated cognitive decline in people with chronic low back pain: A scoping review	41
Rethinking IRPs/IRE system in neurodegenerative disorders: Looking beyond iron metabolism	41
Developing transcriptomic signatures as a biomarker of cellular senescence	41
Caenorhabditis elegans: A transgenic model for studying age-associated neurodegenerative diseases	41
Systematic analysis of nutrigenomic effects of polyphenols related to cardiometabolic health in humans – Evidence from untargeted mRNA and miRNA studies	41
Machine learning in Alzheimer’s disease drug discovery and target identification	41
Can dementia risk be reduced by following the American Heart Association's Life's Simple 7? A systematic review and dose-response meta-analysis	41
Vascular cognitive impairment – Past, present, and future challenges	40
Advances in human cellular mechanistic understanding and drug discovery of brain organoids for neurodegenerative diseases	40
Dysfunction of norepinephrine and its metabolites in Alzheimer's dementia – A review with meta-analysis	40
Fungi as a source of bioactive molecules for the development of longevity medicines	39
Senescence in tissue samples of humans with age-related diseases: A systematic review	39
The emerging role of exosomes in Alzheimer’s disease	39
Advancements in computer-assisted diagnosis of Alzheimer's disease: A comprehensive survey of neuroimaging methods and AI techniques for early detection	38
Prevalence of multidimensional frailty and pre-frailty in older people in different settings: A systematic review and meta-analysis	38
Hypoxia and hemorheological properties in older individuals	38
Past, present and future of therapeutic strategies against amyloid-β peptides in Alzheimer’s disease: a systematic review	38
Disease-modifying therapies for Alzheimer’s disease: Clinical trial progress and opportunity	37
Optimal dose and type of exercise to improve cognitive function in older adults: A systematic review and bayesian model-based network meta-analysis of RCTs	37
miR-21 and miR-146a: The microRNAs of inflammaging and age-related diseases	37
Mitochondrial dysfunction in aging	37
Endogenous retroviruses in multiple sclerosis: A network-based etiopathogenic model	37
Stress, diet, exercise: Common environmental factors and their impact on epigenetic age	37
On the wake of metformin: Do anti-diabetic SGLT2 inhibitors exert anti-aging effects?	36
Treatment avenues for age-related macular degeneration: Breakthroughs and bottlenecks	36
Strides towards healthy longevity: Harnessing the power of sports and elements of Kathak, an Indian classical dance form through social participation to combat cognitive frailty among older adults	36
Fading memories in aging and neurodegeneration: Is p75 neurotrophin receptor a culprit?	36
Ferroptosis: Mechanisms and role in diabetes mellitus and its complications	36
Editorial Board	36
Age differences in pedestrian navigational skills and performance: A systemic review and meta-analysis	35
Effects of digital-based interventions on the outcomes of the eligibility criteria for sarcopenia in healthy older adults: A systematic review and meta-analysis	35
Alcohol consumption in relation to cognitive dysfunction and dementia: A systematic review and dose-response meta-analysis of comparative longitudinal studies	35
Diagnostic accuracy of blood biomarkers for Alzheimer’s disease and amnestic mild cognitive impairment: A meta-analysis	35
Untangle the mystery behind DS-associated AD – Is APP the main protagonist?	35
Biomarkers of synaptic degeneration in Alzheimer’s disease	35
The mitochondrial integrated stress response: A novel approach to anti-aging and pro-longevity	35
Recent advancement in therapeutic strategies for Alzheimer’s disease: Insights from clinical trials	34
Alzheimer’s dementia or Alzheimer’s disease – What’s the difference and why should we care?	34
Virtual reality and cognitive rehabilitation for older adults with mild cognitive impairment: A systematic review	34
Adipose tissue spexin in physical exercise and age-associated diseases	34
HMGB1, an evolving pleiotropic protein critical for cellular and tissue homeostasis: Role in aging and age-related diseases	34
Effects of three kinds of anti-amyloid-β drugs on clinical, biomarker, neuroimaging outcomes and safety indexes: A systematic review and meta-analysis of phase II/III clinical trials in Alzheimer’s di	34
Diagnostic performance of digital cognitive tests for the identification of MCI and dementia: A systematic review	34
14–3-3 protein and its isoforms: A common diagnostic marker for Alzheimer’s disease, Parkinson’s disease and glaucomatous neurodegeneration	33
Triaging between post-translational modification of cell cycle regulators and their therapeutics in neurodegenerative diseases	33
Targeting aging with urolithin A in humans: A systematic review	33
Loss of neuromuscular junction integrity and muscle atrophy in skeletal muscle disuse	33
Overview of a novel osmotin abolishes abnormal metabolic-associated adiponectin mechanism in Alzheimer’s disease: Peripheral and CNS insights	33
Exploring cellular senescence in the musculoskeletal system: Any insights for biomarkers discovery?	33
Mechanisms, consequences and role of interventions for sleep deprivation: Focus on mild cognitive impairment and Alzheimer’s disease in elderly	33
PARP1 at the crossroad of cellular senescence and nucleolar processes	33
ChatGPT's dance with neuropsychological data: A case study in Alzheimer’s disease	33
Epithelial-mesenchymal transition in age-associated thymic involution: Mechanisms and therapeutic implications	33
The role of sirtuin 1 in ageing and neurodegenerative disease: A molecular perspective	33
Cognitive resilience in Alzheimer’s disease: Mechanism and potential clinical intervention	33
The emerging roles of tRNAs and tRNA-derived fragments during aging: Lessons from studies on model organisms	32
Cross-sectional associations of tau protein biomarkers with semantic and episodic memory in older adults without dementia: A systematic review and meta-analysis	32
Neuropsychiatric disturbances in mild cognitive impairment: A scientometric analysis	32
Interventions to prevent and treat delirium: An umbrella review of randomized controlled trials	32
Physiological functions of podosomes: From structure and function to therapy implications in osteoclast biology of bone resorption	32
Editorial Board	31
Editorial Board	31
Editorial Board	31
Editorial Board	31
Editorial Board	31
Protein intake and physical function in older adults: A systematic review and meta-analysis	30
Sestrin2 and mitochondrial quality control: Potential impact in myogenic differentiation	30
Associations of environmental factors with neurodegeneration: An exposome-wide Mendelian randomization investigation	30
Effectiveness and safety of Governor vessel acupuncture therapy for post-stroke cognitive impairment: A meta-analysis of randomized controlled trials	30
The neuromicrobiology of Parkinson’s disease: A unifying theory	30
Cosmic chronometers: Is spaceflight a catalyst for biological ageing?	30
Biomarkers associated with cognitive impairment in post-traumatic stress disorder: A systematic review of current evidence	30
Blood brain barrier dysfunction in healthy aging and dementia: Why, how, what for?	30
Unlocking the therapeutic potential of natural stilbene: Exploring pterostilbene as a powerful ally against aging and cognitive decline	30
Epigenetic enzymes: A role in aging and prospects for pharmacological targeting	30
Involvement of regulated cell deaths in aging and age-related pathologies	29
Overview of pro-inflammatory and pro-survival components in neuroinflammatory signalling and neurodegeneration	29
Lactoferrin/lactoferrin receptor: Neurodegenerative or neuroprotective in Parkinson’s disease?	29
Comparative efficacy of non-invasive brain stimulation on cognition function in patients with mild cognitive impairment: A systematic review and network meta-analysis	29
Neuroimaging and biofluid biomarkers across race and ethnicity in older adults across the spectrum of cognition	29
Mitochondrial dysfunction as a therapeutic strategy for neurodegenerative diseases: Current insights and future directions	29
Detection and management of suspected infections in people with dementia – A scoping review of current practices	29
Emerging microglial biology highlights potential therapeutic targets for Alzheimer's disease	29