Ageing Research Reviews

Article	Citations
Aging in COVID-19: Vulnerability, immunity and intervention	587
Biomarkers, oxidative stress and autophagy in skin aging	308
The role of metabolism in chondrocyte dysfunction and the progression of osteoarthritis	254
Markers of inflammation and their association with muscle strength and mass: A systematic review and meta-analysis	249
A research agenda for ageing in China in the 21st century (2nd edition): Focusing on basic and translational research, long-term care, policy and social networks	241
A systematic review of biological, social and environmental factors associated with epigenetic clock acceleration	211
Immunosenescence and inflammaging in the aging process: age-related diseases or longevity?	180
A multidimensional approach to frailty in older people	172
Sarcopenia – Molecular mechanisms and open questions	165
Oxidative stress and regulated cell death in Parkinson’s disease	162
Oxidative stress: The core pathogenesis and mechanism of Alzheimer’s disease	160
Synaptic basis of Alzheimer’s disease: Focus on synaptic amyloid beta, P-tau and mitochondria	156
Defective mitophagy in Alzheimer’s disease	155
Exercise benefits on Alzheimer’s disease: State-of-the-science	151
Role of mitochondrial quality surveillance in myocardial infarction: From bench to bedside	139
Combined physical and cognitive training for older adults with and without cognitive impairment: A systematic review and network meta-analysis of randomized controlled trials	135
Western diet as a trigger of Alzheimer’s disease: From metabolic syndrome and systemic inflammation to neuroinflammation and neurodegeneration	131
Past, present and future of therapeutic strategies against amyloid-β peptides in Alzheimer’s disease: a systematic review	129
Nrf2: a dark horse in Alzheimer's disease treatment	128
Stress and telomere shortening: Insights from cellular mechanisms	119
Effects of monoclonal antibodies against amyloid-β on clinical and biomarker outcomes and adverse event risks: A systematic review and meta-analysis of phase III RCTs in Alzheimer’s disease	118
The pleiotropic neuroprotective effects of resveratrol in cognitive decline and Alzheimer’s disease pathology: From antioxidant to epigenetic therapy	117
Healthful aging mediated by inhibition of oxidative stress	116
Hypoxia and brain aging: Neurodegeneration or neuroprotection?	115
ACE2 imbalance as a key player for the poor outcomes in COVID-19 patients with age-related comorbidities – Role of gut microbiota dysbiosis	111

The association of objectively measured physical activity and sedentary behavior with skeletal muscle strength and muscle power in older adults: A systematic review and meta-analysis	110
The involvement of NLRP3 inflammasome in the treatment of Alzheimer’s disease	106
Branched chain amino acids, aging and age-related health	105
Prevention of dementia in an ageing world: Evidence and biological rationale	105
Autophagy in Alzheimer’s disease pathogenesis: Therapeutic potential and future perspectives	102
Targeting microglial autophagic degradation in NLRP3 inflammasome-mediated neurodegenerative diseases	102
Biohorology and biomarkers of aging: Current state-of-the-art, challenges and opportunities	101
Biomarkers shared by frailty and sarcopenia in older adults: A systematic review and meta-analysis	99
Wnt signaling pathway in aging-related tissue fibrosis and therapies	99
miR-21 and miR-146a: The microRNAs of inflammaging and age-related diseases	99
Autophagy and the hallmarks of aging	97
Crosstalk between obesity, diabetes, and alzheimer’s disease: Introducing quercetin as an effective triple herbal medicine	97
Circadian and sleep dysfunction in Alzheimer’s disease	95
Cross-sectional and longitudinal associations between adherence to Mediterranean diet with physical performance and cognitive function in older adults: A systematic review and meta-analysis	91
Novel target for treating Alzheimer’s Diseases: Crosstalk between the Nrf2 pathway and autophagy	91
Neuronal excitation/inhibition imbalance: core element of a translational perspective on Alzheimer pathophysiology	90
Mitochondrial dysfunction, oxidative stress, neuroinflammation, and metabolic alterations in the progression of Alzheimer’s disease: A meta-analysis of in vivo magnetic resonance spectroscopy studies	88
Systematic review and analysis of human proteomics aging studies unveils a novel proteomic aging clock and identifies key processes that change with age	86
Single-cell analyses of aging, inflammation and senescence	86
Mitochondria in Ovarian Aging and Reproductive Longevity	84
Mitochondria: Their relevance during oocyte ageing	81
Autophagy in the diabetic heart: A potential pharmacotherapeutic target in diabetic cardiomyopathy	80
Inflammatory pathways in Alzheimer’s disease mediated by gut microbiota	80
Updated systematic review and meta-analysis on diagnostic issues and the prognostic impact of myosteatosis: A new paradigm beyond sarcopenia	79
Omics sciences for systems biology in Alzheimer’s disease: State-of-the-art of the evidence	77
Targeting immune dysfunction in aging	77
Biological and environmental predictors of heterogeneity in neurocognitive ageing	76
The road ahead for health and lifespan interventions	73
Inter and Intracellular mitochondrial trafficking in health and disease	69
Prevalence of multidimensional frailty and pre-frailty in older people in different settings: A systematic review and meta-analysis	69
COVID-19: risk accumulation among biologically and socially vulnerable older populations	69
The role of Nrf2 in neural stem/progenitors cells: From maintaining stemness and self-renewal to promoting differentiation capability and facilitating therapeutic application in neurodegenerative dise	69
Benefits and harms of exercise therapy in people with multimorbidity: A systematic review and meta-analysis of randomised controlled trials	69
Modifiable lifestyle factors and cognitive reserve: A systematic review of current evidence	69
Home-based exercise programmes improve physical fitness of healthy older adults: A PRISMA-compliant systematic review and meta-analysis with relevance for COVID-19	68
The emerging role of exosomes in Alzheimer’s disease	67
The hoverfly and the wasp: A critique of the hallmarks of aging as a paradigm	66
The role of nutrition in inflammaging	66
The ageing kidney: Molecular mechanisms and clinical implications	65
Mitophagy Receptors and Mediators: Therapeutic Targets in the Management of Cardiovascular Ageing	64
Obesity and aging: Molecular mechanisms and therapeutic approaches	64
Optimal dose and type of exercise to improve cognitive function in older adults: A systematic review and bayesian model-based network meta-analysis of RCTs	64
Ageing of the gut microbiome: Potential influences on immune senescence and inflammageing	63
Inflammaging, hormesis and the rationale for anti-aging strategies	63
Re-emphasizing early Alzheimer’s disease pathology starting in select entorhinal neurons, with a special focus on mitophagy	62
Cellular senescence in knee osteoarthritis: molecular mechanisms and therapeutic implications	62
DNA methylation-based age clocks: From age prediction to age reversion	61
Mesenchymal stem cell-derived extracellular vesicle-based therapies protect against coupled degeneration of the central nervous and vascular systems in stroke	61
Towards an understanding of the physical activity-BDNF-cognition triumvirate: A review of associations and dosage	60
Is personality associated with dementia risk? A meta-analytic investigation	60

Biomarkers used in Alzheimer’s disease diagnosis, treatment, and prevention	59
Reactive astrocytes: The nexus of pathological and clinical hallmarks of Alzheimer’s disease	58
Short-chain fatty acid metabolism and multiple effects on cardiovascular diseases	58
Olfactory dysfunction in aging and neurodegenerative diseases	57
Epigenetic regulation of melanogenesis	57
Elastic fibers during aging and disease	57
Dysbiosis, malnutrition and enhanced gut-lung axis contribute to age-related respiratory diseases	57
From DNA damage to mutations: All roads lead to aging	56
The accelerated aging phenotype: The role of race and social determinants of health on aging	56
Promising biomarkers of human aging: In search of a multi-omics panel to understand the aging process from a multidimensional perspective	54
Effects of exercise interventions on the functional status of acutely hospitalised older adults: A systematic review and meta-analysis	54
The geroscience agenda: Toxic stress, hormetic stress, and the rate of aging	54
Nutrition and the ageing brain: Moving towards clinical applications	53
Ozone: a natural bioactive molecule with antioxidant property as potential new strategy in aging and in neurodegenerative disorders	53
Calorie restriction for enhanced longevity: The role of novel dietary strategies in the present obesogenic environment	53
A common signature of cellular senescence; does it exist?	53
The role of the immune system in Alzheimer’s disease	53
Deregulated mitochondrial microRNAs in Alzheimer's disease: Focus on synapse and mitochondria	53
Deterioration of nuclear morphology and architecture: A hallmark of senescence and aging	52
Center of pressure displacement characteristics differentiate fall risk in older people: A systematic review with meta-analysis	52
The hyperfunction theory: An emerging paradigm for the biology of aging	51
Is living alone a risk factor of frailty? A systematic review and meta-analysis	51
COVID-19 mortality as a fingerprint of biological age	49
The neurobiology of non-coding RNAs and Alzheimer’s disease pathogenesis: Pathways, mechanisms and translational opportunities	49
Frailty prevalence and impact on outcomes in patients with atrial fibrillation: A systematic review and meta-analysis of 1,187,000 patients	49
Targeting autophagy in osteoporosis: From pathophysiology to potential therapy	48
Epigenetic clock: A promising biomarker and practical tool in aging	48
The protective role of exercise against age-related neurodegeneration	48
The dialogue between the ubiquitin-proteasome system and autophagy: Implications in ageing	47
Exercise interventions in Alzheimer’s disease: A systematic review and meta-analysis of randomized controlled trials	47
Perivascular adipose tissue in age-related vascular disease	47
Post-translational modifications: Regulators of neurodegenerative proteinopathies	46
Retinal biomarkers in Alzheimer’s disease and mild cognitive impairment: A systematic review and meta-analysis	46
Iron homeostasis and organismal aging	46
New insights into the interplay between miRNAs and autophagy in the aging of intervertebral discs	46
Monoamine oxidases in age-associated diseases: New perspectives for old enzymes	45
GDF15, an emerging key player in human aging	44
Brain lipid peroxidation and alzheimer disease: Synergy between the Butterfield and Mattson laboratories	44
Attenuation of 7-ketocholesterol- and 7β-hydroxycholesterol-induced oxiapoptophagy by nutrients, synthetic molecules and oils: Potential for the prevention of age-related diseases	44
Telomere transcription in ageing	44
Social hallmarks of aging: Suggestions for geroscience research	43
Living alone and risk of dementia: A systematic review and meta-analysis	43
Hormesis and Ginkgo biloba (GB): Numerous biological effects of GB are mediated via hormesis	43
Diabetes mellitus and hearing loss: A review	43
The role of serotonin within the microbiota-gut-brain axis in the development of Alzheimer’s disease: A narrative review	42
Lamin A involvement in ageing processes	42
Pleiotropic effects of alpha-ketoglutarate as a potential anti-ageing agent	42
Osteocytes in bone aging: Advances, challenges, and future perspectives	42
Nutritional domains in frailty tools: Working towards an operational definition of nutritional frailty	42
Exploring ER stress response in cellular aging and neuroinflammation in Alzheimer's disease	42
Associations between nutrition and the incidence of depression in middle-aged and older adults: A systematic review and meta-analysis of prospective observational population-based studies	42
Fibroageing: An ageing pathological feature driven by dysregulated extracellular matrix-cell mechanobiology	42
Efficacy of lifestyle and psychosocial interventions in reducing cognitive decline in older people: Systematic review	42
Potential roles of gut microbiota and microbial metabolites in Parkinson’s disease	42
Lipocalin 2 as a link between ageing, risk factor conditions and age-related brain diseases	41
Time-restricted feeding (TRF) for prevention of age-related vascular cognitive impairment and dementia	41
Role of indoleamine 2,3-dioxygenase 1 (IDO1) and kynurenine pathway in the regulation of the aging process	41
The complex associations between late life depression, fear of falling and risk of falls. A systematic review and meta-analysis	41
Neurogenesis in aging and age-related neurodegenerative diseases	41
Curcumin nanoformulations to combat aging-related diseases	41
Targeting senescent cells to attenuate cardiovascular disease progression	40
Cerebral blood flow in mild cognitive impairment and Alzheimer’s disease: A systematic review and meta-analysis	40
Mechanosensing dysregulation in the fibroblast: A hallmark of the aging heart	40
Effects of exergames and cognitive-motor dual-task training on cognitive, physical and dual-task functions in cognitively healthy older adults: An overview	40
Glial cells in Alzheimer’s disease: From neuropathological changes to therapeutic implications	39
Frailty is highly prevalent in specific cardiovascular diseases and females, but significantly worsens prognosis in all affected patients: A systematic review	39
The Role of Rapamycin in Healthspan Extension via the Delay of Organ Aging	38
Exosome: A novel neurotransmission modulator or non-canonical neurotransmitter?	38
Oxidized nicotinamide adenine dinucleotide-dependent mitochondrial deacetylase sirtuin-3 as a potential therapeutic target of Parkinson’s disease	38
Toward noninvasive brain stimulation 2.0 in Alzheimer’s disease	37
Unsupervised home-based resistance training for community-dwelling older adults: A systematic review and meta-analysis of randomized controlled trials	37
The potential roles of deubiquitinating enzymes in brain diseases	37
Sarcopenia definition: Does it really matter? Implications for resistance training	37
Astrocyte mitochondria: Central players and potential therapeutic targets for neurodegenerative diseases and injury	37
Interactions between glial cells and the blood-brain barrier and their role in Alzheimer's disease	37
Recent advances in the field of caloric restriction mimetics and anti-aging molecules	37
Stochastic non-enzymatic modification of long-lived macromolecules - A missing hallmark of aging	36
Age-related changes in muscle architecture and metabolism in humans: The likely contribution of physical inactivity to age-related functional decline	36
Iron homeostasis in arthropathies: From pathogenesis to therapeutic potential	36
Artificial intelligence in brain MRI analysis of Alzheimer’s disease over the past 12 years: A systematic review	36

Fatigue and the prediction of negative health outcomes: A systematic review with meta-analysis	36
Heart rate variability in relation to cognition and behavior in neurodegenerative diseases: A systematic review and meta-analysis	36
Efficacy of non-invasive brain stimulation on global cognition and neuropsychiatric symptoms in Alzheimer’s disease and mild cognitive impairment: A meta-analysis and systematic review	35
Identification of altered exosomal microRNAs and mRNAs in Alzheimer's disease	35
DNA damage repair response in mesenchymal stromal cells: From cellular senescence and aging to apoptosis and differentiation ability	35
Aging adipose: Depot location dictates age-associated expansion and dysfunction	34
Does eNOS derived nitric oxide protect the young from severe COVID-19 complications?	34
Feed-forward regulation between cellular senescence and immunosuppression promotes the aging process and age-related diseases	34
Blood fatty acids in Alzheimer’s disease and mild cognitive impairment: A meta-analysis and systematic review	34
Fostering healthy aging: The interdependency of infections, immunity and frailty	34
Cortisol hypersecretion and the risk of Alzheimer’s disease: A systematic review and meta-analysis	34
Prevalence of unwillingness and uncertainty to vaccinate against COVID-19 in older people: A systematic review and meta-analysis	33
The emerging role of the sympathetic nervous system in skeletal muscle motor innervation and sarcopenia	33
Senescence in tissue samples of humans with age-related diseases: A systematic review	33
The emerging role of T follicular helper (TFH) cells in aging: Influence on the immune frailty	33
Role of Nrf2 in aging, Alzheimer’s and other neurodegenerative diseases	33
Noncoding RNAs in age-related cardiovascular diseases	33
Risk factors for falls in older people with cognitive impairment living in the community: Systematic review and meta-analysis	33
Targeting metabolic pathways for extension of lifespan and healthspan across multiple species	32
An elusive consensus definition of sarcopenia impedes research and clinical treatment: A narrative review	32
Therapy for Alzheimer’s disease: Missing targets and functional markers?	32
Emerging pathogenic role of peripheral blood factors following BBB disruption in neurodegenerative disease	32
Structure-functional implications of longevity protein p66Shc in health and disease	32
The potential role of melatonin in retarding intervertebral disc ageing and degeneration: A systematic review	32
Reducing neuroinflammation via therapeutic compounds and lifestyle to prevent or delay progression of Parkinson’s disease	32
Transcranial magnetic stimulation (TMS) for geriatric depression	32
Does oxidative stress shorten telomeres in vivo? A meta-analysis	32
Defining and assessing intrinsic capacity in older people: A systematic review and a proposed scoring system	32
Thymus involution sets the clock of the aging T-cell landscape: Implications for declined immunity and tissue repair	31
Fight to the bitter end: DNA repair and aging	31
Diagnostic performance of digital cognitive tests for the identification of MCI and dementia: A systematic review	31
Formaldehyde toxicity in age-related neurological dementia	31
A systematic review of the impacts of intergenerational engagement on older adults’ cognitive, social, and health outcomes	31
From beta amyloid to altered proteostasis in Alzheimer’s disease	31
Functional roles of circular RNAs in Alzheimer’s disease	31
PINK1/Parkin-mediated mitophagy in neurodegenerative diseases	31
How good is the evidence that cellular senescence causes skin ageing?	31
Pleiotropic effects of polyphenols on glucose and lipid metabolism: Focus on clinical trials	30
Hippuric acid: Could became a barometer for frailty and geriatric syndromes?	30
Roles of clock genes in the pathogenesis of Parkinson's disease	30
Research progress in the use of mesenchymal stem cells and their derived exosomes in the treatment of osteoarthritis	29
The impact of aerobic and resistance training intensity on markers of neuroplasticity in health and disease	29
Senescent cells as promising targets to tackle age-related diseases	29
Region-specific vulnerability in neurodegeneration: lessons from normal ageing	29
Stepping impairment and falls in older adults: A systematic review and meta-analysis of volitional and reactive step tests	29
Salivary biomarkers of neurodegenerative and demyelinating diseases and biosensors for their detection	28
Emerging potential of cannabidiol in reversing proteinopathies	28
Exploring the multifunctional role of melatonin in regulating autophagy and sleep to mitigate Alzheimer’s disease neuropathology	28
Melatonin: A novel candidate for the treatment of osteoarthritis	27
Ubiquitin biology in neurodegenerative disorders: From impairment to therapeutic strategies	27
Aging-suppressor Klotho: Prospects in diagnostics and therapeutics	27
Dissecting primary and secondary senescence to enable new senotherapeutic strategies	27
Estimates of malnutrition and risk of malnutrition among the elderly (≥60 years) in India: A systematic review and meta-analysis	27
Proteomics as a reliable approach for discovery of blood-based Alzheimer’s disease biomarkers: A systematic review and meta-analysis	27
Female specific risk factors for the development of Alzheimer’s disease neuropathology and cognitive impairment: Call for a precision medicine approach	26
Targeting brain Renin-Angiotensin System for the prevention and treatment of Alzheimer’s disease: Past, present and future	26
Socioeconomic position and healthy ageing: A systematic review of cross-sectional and longitudinal studies	26
Roles and mechanisms of MFG-E8 in vascular aging-related diseases	26
Anthocyanin as a therapeutic in Alzheimer’s disease: A systematic review of preclinical evidences	26
β-amyloid: The known unknowns	26
Underrepresentation of older adults in clinical trials on COVID-19 vaccines: A systematic review	26
The multi-faceted impact of methamphetamine on Alzheimer’s disease: From a triggering role to a possible therapeutic use	26
Effects of influenza vaccination on the risk of cardiovascular and respiratory diseases and all-cause mortality	25
Brain drug delivery and neurodegenerative diseases: Polymeric PLGA-based nanoparticles as a forefront platform	25
Multi-omics research in sarcopenia: Current progress and future prospects	25
Socially assistive robots for people with dementia: Systematic review and meta-analysis of feasibility, acceptability and the effect on cognition, neuropsychiatric symptoms and quality of life	25
Risk for Alzheimer’s disease: A review of long-term episodic memory encoding and retrieval fMRI studies	25
Mechanisms linking mitochondrial mechanotransduction and chondrocyte biology in the pathogenesis of osteoarthritis	25
Role of microRNAs in neurodegeneration induced by environmental neurotoxicants and aging	25
Environmental factors and risks of cognitive impairment and dementia: A systematic review and meta-analysis	25
Prepulse inhibition of the acoustic startle reflex and P50 gating in aging and alzheimer’s disease	25
Altered endocytosis in cellular senescence	25
Systemic manifestation and contribution of peripheral tissues to Huntington’s disease pathogenesis	25
MRI-based biomarkers of accelerated aging and dementia risk in midlife: how close are we?	24
Immunometabolic responses according to physical fitness status and lifelong exercise during aging: New roads for exercise immunology	24
The effect of Tai Chi in elderly individuals with sarcopenia and frailty: A systematic review and meta-analysis of randomized controlled trials	24
Vascular dementia: A microglia's perspective	24
Blood pressure variability: A potential marker of aging	24
Assessing the rate of aging to monitor aging itself	24
Protein S-sulfhydration: Unraveling the prospective of hydrogen sulfide in the brain, vasculature and neurological manifestations	24
Searching for the link between inflammaging and sarcopenia	24
Skin photo-protection with phytochemicals against photo-oxidative stress, photo-carcinogenesis, signal transduction pathways and extracellular matrix remodeling—An overview	24
Transposable elements in brain health and disease	24
Associations of dietary markers with brain volume and connectivity: A systematic review of MRI studies	24
lncRNA NEAT1: Key player in neurodegenerative diseases	24
Mitochondrial dysfunction in aging	24
Frailty biomarkers under the perspective of geroscience: A narrative review	24