Ageing Research Reviews

Article	Citations
Start the engine of neuroregeneration: A mechanistic and strategic overview of direct astrocyte-to-neuron reprogramming	320
Editorial Board	289
The functions of IRE1α in neurodegenerative diseases: Beyond ER stress	288
Editorial Board	271
Roles of hypoxia-inducible factor-prolyl hydroxylases in aging and disease	252
cGAS-STING-driven inflammaging cascade in aging-related retinal diseases: From pathological mechanism to therapeutic potentials	246
Type 2 diabetes mellitus augments Parkinson’s disease risk or the other way around: Facts, challenges and future possibilities	226
The m⁶A epitranscriptome: A regulatory nexus linking cellular senescence and oncogenesis	197
Dysfunction of norepinephrine and its metabolites in Alzheimer's dementia – A review with meta-analysis	196
Adenosine metabolism and receptors in aging of the skin, musculoskeletal, immune and cardiovascular systems	188
Thioredoxin-1 inhibits the activation of IRE1 by targeting Hsp90/p-Cdc37 chaperone complex in Parkinson disease	184
Effectiveness of virtual reality interventions on quality of life, cognitive function and physical function in older people with Alzheimer's disease: A systematic review	178
Advances in clinical application of lipidomics in healthy ageing and healthy longevity medicine	177
Ergothioneine and exercise: A match made in (cognitive) heaven?	171
Discovery of a new hereditary RECQ helicase disorder RECON syndrome positions the replication stress response and genome homeostasis as centrally important processes in aging and age-related disease	170
HIV infection is associated with accelerated epigenetic ageing: A systematic review	158
Editor’s Note to “Biological constraint, evolutionary spandrels and antagonistic pleiotropy”	156
The unique neuropathological vulnerability of the human brain to aging	152
Reevaluating principal component analysis in geroscience: A call for nonlinear approaches in AI-based evaluations	152
CC chemokines family in fibrosis and aging: From mechanisms to therapy	145
Medication reviews in hospitalised patients for reduced hospital readmission and mortality. Systematic review, meta-analysis and meta-regression of RCTs	144
The past, present, and future of adipose tissue browning and aging: A review combined with bibliometrics and bioinformatics of 2527 documents published over the past four decades	144
Can dementia risk be reduced by following the American Heart Association's Life's Simple 7? A systematic review and dose-response meta-analysis	138
From ageing clocks to organ networks: Biological age-driven organ asynchrony and inter-organ interactions shaping mortality risk	137
Unravelling the brain resilience following stroke: From injury to rewiring of the brain through pathway activation, drug targets, and therapeutic interventions	135

Guardians of homeostasis: Natural products target metabolic reprogramming in Alzheimer’s disease	135
Sarcobesity: New paradigms for healthy aging related to taurine supplementation, gut microbiota and exercise	134
Microglia and gut microbiota: A double-edged sword in Alzheimer's disease	131
Organelle interactome disruption: The systemic pathological mechanisms and therapeutic prospects of mitochondria-lysosome-ER crosstalk in Alzheimer's disease	127
Does drug repurposing bridge the gaps in management of Parkinson’s disease? Unravelling the facts and fallacies	125
Advances in Alzheimer's therapy: Exploring neuropathological mechanisms to revolutionize the future therapeutic landscape	123
Repetitive transcranial magnetic stimulation combined with cognitive training for cognitive function and activities of daily living in patients with post-stroke cognitive impairment: A systematic revi	123
Efficacy of technology-based cognitive and exercise interventions for mild cognitive impairment: A systematic review, network meta-analysis, and meta-regression of randomized controlled trials	120
Histopathological and ultrastructural changes in different cell types during ischemic and hemorrhagic stroke	119
Prevalence and health outcomes of polypharmacy and hyperpolypharmacy in older adults with frailty: A systematic review and meta-analysis	119
Vascular cognitive impairment – Past, present, and future challenges	117
Global, regional, and national burden of spinal cord injury from 1990 to 2021 and projections for 2050: A systematic analysis for the Global Burden of Disease 2021 study	116
Unraveling the protein post-translational modification landscape: Neuroinflammation and neuronal death after stroke	116
Glymphatic dysfunction in Parkinson's disease: Aging-associated impairments, imaging biomarkers, and therapeutic strategies	116
Cerebral glymphatic system: Structure, regulation, ageing, and mechanisms of encephalopathy	115
Quality and recommendations of guidelines for multimorbidity and polypharmacy in older adults: A systematic review	112
HMGB1, an evolving pleiotropic protein critical for cellular and tissue homeostasis: Role in aging and age-related diseases	111
Betaine and aging: A narrative review of findings, possible mechanisms, research perspectives, and practical recommendations	110
The several ways to authentically cure Alzheimer’s dementia	109
Biomarkers associated with cognitive impairment in post-traumatic stress disorder: A systematic review of current evidence	106
Hallmarks of aging: A user’s guide for comparative biologists	106
Exercise and the hallmarks of cardiovascular aging	105
Involvement of regulated cell deaths in aging and age-related pathologies	104
Potential convergence of olfactory dysfunction in Parkinson’s disease and COVID-19: The role of neuroinflammation	103
Interventions to prevent and treat delirium: An umbrella review of randomized controlled trials	102
Triaging between post-translational modification of cell cycle regulators and their therapeutics in neurodegenerative diseases	100
The link between metabolic syndrome and Alzheimer disease: A mutual relationship and long rigorous investigation	99
Advances of artificial intelligence in predicting frailty using real-world data: A scoping review	98
Cytosolic DNA sensor IFI16 proteins: Potential molecular integrators of interactions among the aging hallmarks	98
Research progress in Alzheimer's disease and bone-brain axis	96
A Multimodal Meta-Analytical Evidence of Functional and Structural Brain Abnormalities Across Alzheimer's Disease Spectrum	96
The role of the PLA2G6 gene in neurodegenerative diseases	95
Multifaceted cell death in atherosclerosis: Mechanisms, pathological impact, and therapeutic targeting	95
Sensory nerve regulation of bone homeostasis: Emerging therapeutic opportunities for bone-related diseases	94
Protein and peptide based nanotherapeutics for the management of Alzheimer’s disease: Current insights and future directions	94
Targeting aging with urolithin A in humans: A systematic review	93
On the wake of metformin: Do anti-diabetic SGLT2 inhibitors exert anti-aging effects?	92
Adherence to the Mediterranean diet and risk of frailty and pre-frailty in elderly adults: A systematic review and dose-response meta-analysis with GRADE assessment	92
Three-dimensional human brain organoids: A next-generation model to decode Alzheimer’s disease	92
Insulin resistance as a mediator of physical activity's effects on beta-amyloid accumulation and tau phosphorylation: A scoping review	89
Artificial intelligence for fall detection in older adults: A comprehensive survey of machine learning, deep learning approaches, and future directions	86
Overview of pro-inflammatory and pro-survival components in neuroinflammatory signalling and neurodegeneration	86
Role of diet and exercise in aging, Alzheimer’s disease, and other chronic diseases	86
Cognitive resilience in Alzheimer’s disease: Mechanism and potential clinical intervention	86
Bridging neurotrophic factors and bioactive peptides to Alzheimer's disease	86
Associations of olfactory function with brain structural and functional outcomes. A systematic review	84
Identification of exosomal biomarkers and its optimal isolation and detection method for the diagnosis of Parkinson's disease: A systematic review and meta-analysis	84
Mitochondria-associated endoplasmic reticulum membranes as aging-sensitive signaling hubs in degenerative musculoskeletal diseases	84
New era of artificial intelligence and machine learning-based detection, diagnosis, and therapeutics in Parkinson’s disease	82
Blood-based biomarkers for Alzheimer's disease: Advances in early detection and monitoring of age-related neurodegeneration	81

Neuroprotection by agmatine: Possible involvement of the gut microbiome?	81
The mitochondrial integrated stress response: A novel approach to anti-aging and pro-longevity	81
Transcranial direct current stimulation combined with motor training for motor symptoms in Parkinson's disease: A systematic review and meta-analysis	80
Characterization of the logopenic variant of Primary Progressive Aphasia: A systematic review and meta-analysis	80
The role of the gut microbiota in neuropsychiatric disorders and therapy	79
Unravelling the miscellaneous effects of exercise interventions on activities of daily living in frail older adults: A systematic review and meta-analysis	79
Melatonin: Potential avenue for treating iron overload disorders	78
Lipids and lipid metabolism in cellular senescence: Emerging targets for age-related diseases	78
The effectiveness of dance movement interventions for older adults with mild cognitive impairment, Alzheimer’s disease, and dementia: A systematic scoping review and meta-analysis	78
Under the umbrella of depression and Alzheimer’s disease physiopathology: Can cannabinoids be a dual-pleiotropic therapy?	77
The role of exercise in the prevention and treatment of Alzheimer’s disease and mild cognitive impairments	77
Suicide and dementia: A systematic review and meta-analysis of prevalence and risk factors	77
Turquoise killifish: A natural model of age-dependent brain degeneration	75
Association of frailty and pre-frailty with all-cause and cardiovascular mortality in diabetes: Three prospective cohorts and a meta-analysis	74
A novel regulator in Alzheimer's disease progression: The astrocyte-derived extracellular vesicles	74
The role of in silico and in vitro models in Parkinson’s disease: Drug discovery and therapy applications	74
Oral health indicators and bone mineral density disorders in older age: A systematic review	74
ADP-ribosylation, a multifaceted modification: Functions and mechanisms in aging and aging-related diseases	73
Unravelling of molecular biomarkers in synaptic plasticity of Alzheimer’s disease: Critical role of the restoration of neuronal circuits	73
The effect of ferroptosis-related mitochondrial dysfunction in the development of temporal lobe epilepsy	73
Drug repositioning for Parkinson’s disease: An emphasis on artificial intelligence approaches	73
Intracellular effects of lithium in aging neurons	73
Association between pulse wave velocity and white matter hyperintensities among older adults: A meta-analysis of cross-sectional and longitudinal studies	72
Latest developments of microphysiological systems (MPS) in aging-related and geriatric diseases research: A review	71
A critical appraisal of blood-based biomarkers for Alzheimer’s disease	71
Molecular hydrogen therapy: A “democratic” emerging strategy against aging and age-related diseases	71
Fanconi anaemia as a human model of accelerated epigenetic and immune ageing	71
Beyond the Hayflick limit: How microbes influence cellular aging	70
Expanding evolutionary theories of ageing to better account for symbioses and interactions throughout the Web of Life	70
Computerized cognitive training in Parkinson’s disease: A systematic review and meta-analysis	70
The future of stem cell therapies of Alzheimer’s disease	69
Biological constraint, evolutionary spandrels and antagonistic pleiotropy	69
Healthy brain aging and delayed dementia in Texas rural elderly	69
Modulators of ASIC1a and its potential as a therapeutic target for age-related diseases	69
The plasticity of fibroblasts: A forgotten player in the aging process	68
Modifiable risk factors for mild cognitive impairment among cognitively normal community-dwelling older adults: A systematic review and meta-analysis	68
Long-term human spaceflight and inflammaging: Does it promote aging?	67
HADHA in cardiovascular disease: From mitochondrial dysfunction to therapeutic targets	67
Targeting the gut microbiota-related metabolites for osteoporosis: The inextricable connection of gut-bone axis	67
The cross-talk between the cGAS-STING signaling pathway and chronic inflammation in the development of musculoskeletal disorders	67
cGAS-STING targeting offers novel therapeutic opportunities in neurological diseases	66
Role of Nrf2 in aging, Alzheimer’s and other neurodegenerative diseases	66
Serotonin-mediated regulation of mitophagy in Alzheimer's disease: Mechanistic insights and therapeutic potential	66
Is COVID-19 really a geriatric syndrome?	65
Frailty and the brain: A narrative review of functional and pathological correlates	65
Regulated cell death in acute myocardial infarction: Molecular mechanisms and therapeutic implications	65
Aryl hydrocarbon receptor: From pathogenesis to therapeutic targets in aging-related tissue fibrosis	65
Advances in eye-brain axis: Anatomy, immunity, and association with visual dysfunction	65
Restoration of epigenetic impairment in the skeletal muscle and chronic inflammation resolution as a therapeutic approach in sarcopenia	64
Evaluating senescence-targeted approaches in Alzheimer’s Disease: What we know and what lies ahead	64
BACE1-dependent metabolism of neuregulin 1: Bridging the gap in explaining the occurrence of schizophrenia-like symptoms in Alzheimer's disease with psychosis?	63
Unlocking the potential of histone deacetylase inhibitors in combatting age-related retinal degenerative diseases	63
NAD⁺ supplementation for anti-aging and wellness: A PRISMA-guided systematic review of preclinical and clinical evidence	63
Underserved groups in dysphagia intervention trials in Parkinson’s disease: A scoping review	63
Alzheimer's disease and Alzheimer’s disease-related dementias in Hispanics: Identifying influential factors and supporting caregivers	63
Transposable elements and their role in aging	63
Neurobiology of depression in Parkinson’s disease: Insights into epidemiology, molecular mechanisms and treatment strategies	62
Aryl hydrocarbon receptor (AhR) impairs circadian regulation: Impact on the aging process	62
Recent advancement in understanding of Alzheimer's disease: Risk factors, subtypes, and drug targets and potential therapeutics	62
Antioxidants in anti‐Alzheimer's disease drug discovery	62
Global burden, risk factors, and projections of early-onset dementia: Insights from the Global Burden of Disease Study 2021	61
Telomere length and brain aging: A systematic review and meta-analysis	61
Consolidating multiple evolutionary theories of ageing suggests a need for new approaches to study genetic contributions to ageing decline	61
Resolution of inflammation, an active process to restore the immune microenvironment balance: A novel drug target for treating arterial hypertension	61
Decoding synaptic imbalance in neurodegenerative diseases: From pathological analysis to targeted intervention	61
The mechanisms of mitochondrial abnormalities that contribute to sleep disorders and related neurodegenerative diseases	60
Mortality prediction models for community-dwelling older adults: A systematic review	60
A review on neurodegeneration in the fast-ageing killifish, the first animal model to study the natural occurrence of neuronal cell loss	60
The memory- and cognition-facilitating effects of spermidine in aging and aging-related disorders	59
The metabolic and endocrine impact of diet-derived gut microbiota metabolites on ageing and longevity	59
Brain drug delivery and neurodegenerative diseases: Polymeric PLGA-based nanoparticles as a forefront platform	59
Hormesis defines the limits of lifespan	59
From onset to advancement: the temporal spectrum of α-synuclein in synucleinopathies	59
Biomarkers of female reproductive aging in gerotherapeutic clinical trials	58
Small molecule modulators of alpha-synuclein aggregation and toxicity: Pioneering an emerging arsenal against Parkinson’s disease	58
The mechanism of cuproptosis in Parkinson’s disease	58
Association between lipocalin-2 and mild cognitive impairment or dementia: A systematic review and meta-analysis of population-based evidence	58
Editorial Board	58
Impact of exercise intervention-based changes on physical function biomarkers in older adults after hospital discharge: A systematic review with meta-analysis of randomized clinical trials	57
Cerebellar pathology in forensic and clinical neuroscience	56

Next-generation biosensor technologies for Alzheimer’s disease: Innovations in diagnosis, monitoring, and treatment	56
Single-cell sequencing insights into the transcriptional landscape of Parkinson's disease	56
Epidemiological trends and cross-country inequalities in the global burden of Alzheimer's disease and other dementias in postmenopausal women from 1990 to 2021	55
FAM19A5 in vascular aging and osteoporosis: Mechanisms and the “calcification paradox”	55
Understanding age-related pathologic changes in TDP-43 functions and the consequence on RNA splicing and signalling in health and disease	55
Cerebral small vessel disease pathology in COVID-19 patients: A systematic review	55
Associations between vision impairment and eye diseases with dementia, dementia subtypes and cognitive impairment: An umbrella review	55
Ageing and liver immune cells	55
Modulating α-synuclein propagation and decomposition: Implications in Parkinson's disease therapy	55
Impact of frailty on all-cause mortality or major amputation in patients with lower extremity peripheral artery disease: A meta-analysis	55
Glial cells in Alzheimer’s disease: From neuropathological changes to therapeutic implications	54
The impact of ageing on faecal short chain fatty acids levels in apparently healthy adults: A systematic review and meta-analysis	54
Prevalence of psychotic symptoms in mild cognitive impairment: A systematic review and meta-analysis	54
Lactylation: Unlocking the regulatory code of exercise-mediated anti-aging	54
Blood pressure variability: A potential marker of aging	54
Multi-omics strategies to decode the molecular landscape of cellular senescence	53
The role of DEAD-box helicases in cardiovascular diseases	53
RNA binding proteins in senescence: A potential common linker for age-related diseases?	53
The STAT3 paradox in aging: Molecular mechanisms and targeted therapeutic strategies	53
Exploring Parkinson-associated kinases for CRISPR/Cas9-based gene editing: beyond alpha-synuclein	52
Fractal dimension of the brain in neurodegenerative disease and dementia: A systematic review	52
Heat stroke: Pathogenesis, diagnosis, and current treatment	52
Efficacy of rehabilitation robot-assisted gait training on lower extremity dyskinesia in patients with Parkinson's disease: A systematic review and meta-analysis	52
Epigenetic biomarkers in Alzheimer's disease: Diagnostic and prognostic relevance	52
Mitochondrial transfer between cell crosstalk – An emerging role in mitochondrial quality control	52
Effect of ketogenic diets on insulin-like growth factor (IGF)-1 in humans: A systematic review and meta-analysis	52
Long-term fasting and its influence on inflammatory biomarkers: A comprehensive scoping review	51
Sirtuins in Parkinson's disease: Molecular mechanisms and pathophysiological roles	51
Prevalence of alcohol use among U.S. older adults with pain: A scoping review	50
Biological resilience and aging: Activation of stress response pathways contributes to lifespan extension	50
The senotherapeutic potential of phytochemicals for age-related intestinal disease	50
Liver X receptors and the hallmarks of aging: From molecular mechanisms to therapeutic opportunities	50
Editorial Board	49
Nanotechnology-based advancements in Parkinson's therapy: Exploring animal models and clinical insights in neurodegenerative disorders	49
Adipose tissue and ovarian aging: Potential mechanism and protective strategies	49
Editorial Board	49
The conceivable role of prolactin hormone in Parkinson disease: The same goal but with different ways	49
Targeting impaired nutrient sensing via the sirtuin pathway with novel compounds to prevent or treat dementia: A systematic review	49
Is cognitive reserve associated with the prevention of cognitive decline after stroke? A Systematic review and meta-analysis	48
Osteoporosis and Alzheimer´s disease (or Alzheimer´s disease and Osteoporosis)	48
Resolving the current controversy of use and reuse of housekeeping proteins in ageing research: Focus on saving people’s tax dollars	48
Deciphering the mechanistic impact of acupuncture on the neurovascular unit in acute ischemic stroke: Insights from basic research in a narrative review	48
Markers of biological age in dogs	47
Cannabidiol and neurodegeneration: From molecular mechanisms to clinical benefits	47
Updates on brain regions and neuronal circuits of movement disorders in Parkinson’s disease	47
The prognostic impacts of frailty on clinical and patient-reported outcomes in patients undergoing coronary artery or valvular surgeries/procedures: A systematic review and meta-analysis	46
Multi-omics research strategies in ischemic stroke: A multidimensional perspective	46
Osteosarcopenic adiposity (OSA) phenotype and its connection with cardiometabolic disorders: Is there a cause-and-effect?	46
Neurobiological role and therapeutic potential of exercise-induced irisin in Alzheimer's disease management	46
Mechanosensitive Piezo1 channel in physiology and pathophysiology of the central nervous system	46
Towards a comprehensive framework for complex walking tasks: Characterization, behavioral adaptations, and clinical implications in ageing and neurological populations	46
The interplay of NAD and hypoxic stress and its relevance for ageing	45
Dementia, osteoporosis and fragility fractures: Intricate epidemiological relationships, plausible biological connections, and twisted clinical practices	45
Research progress on carotid artery changes and cognitive impairment in Alzheimer's disease patients	45
MSC-EVs alleviate osteoarthritis by regulating microenvironmental cells in the articular cavity and maintaining cartilage matrix homeostasis	45
Nuclear receptors in age-related diseases: From mechanisms to drug discovery	45
A cross-talk between sestrins, chronic inflammation and cellular senescence governs the development of age-associated sarcopenia and obesity	45
Exerkines: Potential regulators of diabetic cardiomyopathy	44
The role of oxidative stress in intervertebral disc degeneration: Mechanisms and therapeutic implications	44
Editorial Board	44
The impact of aging on HIV-1-related neurocognitive impairment	44
Effects of exercise interventions on cognitive functions in healthy populations: A systematic review and meta-analysis	44
Reducing Alzheimer’s disease risk with SGLT2 inhibitors: From glycemic control to neuroprotection	44
Epigenetic clock: A promising biomarker and practical tool in aging	44
Editorial Board	43
Harnessing two-dimensional nanomaterials for diagnosis and therapy in neurodegenerative diseases: Advances, challenges and prospects	43
Mendelian randomization analyses reveal relationships between white matter microstructure and risk of abdominal aortic aneurysm	43
The association of living alone and social isolation with sarcopenia: A systematic review and meta-analysis	43
Precision neurology	43
Advances in human cellular mechanistic understanding and drug discovery of brain organoids for neurodegenerative diseases	43
Semaglutide as a possible therapy for healthy aging: Targeting the hallmarks of aging	43
Modeling aging in a culture dish: towards the development of more sophisticated in vitro models of human skin aging	42
Pyroptosis: Mechanisms and links with diabetic cardiomyopathy	42
Exploring cytokines dynamics: Uncovering therapeutic concepts for metabolic disorders in postmenopausal women- diabetes, metabolic bone diseases, and non-alcohol fatty liver disease	42
S100A8/A9 as a central hub in inflammaging: Cross-system mechanisms	42
Mapping the immune-genetic architecture of aging: A single-cell causal framework for biomarker discovery and therapeutic targeting	42
Testicular aging revisited: Current understanding of mechanisms and emerging interventions	42
Ageing of human myofibres in the Vastus Lateralis muscle: A narrative review	42
Advancements in computer-assisted diagnosis of Alzheimer's disease: A comprehensive survey of neuroimaging methods and AI techniques for early detection	41
Motoric cognitive risk syndrome as a predictive factor of cognitive impairment and dementia – A systematic review and meta-analysis	41
Progress in the mechanisms of pain associated with neurodegenerative diseases	41
Unknown roles of tau pathology in neurological disorders. Challenges and new perspectives	41
The social microbiome of older people	41
The ethics case for longevity science	41
Is it time to revise the fighting strategy toward type 2 diabetes? Sex and pollution as new risk factors	41
Definitions of healthspan: A systematic review	40
Risk factors for multimorbidity in adulthood: A systematic review	40
Sarcopenia defined by the psoas muscle mass or quality is associated with poor survival in patients with aortic aneurysm undergoing surgery: A meta-analysis	40
Reelin links Apolipoprotein E4, Tau, and Amyloid‐β in Alzheimer’s disease	40
Gut microbiome and Alzheimer’s disease: What we know and what remains to be explored	40
Curcumin-loaded polymeric nanomaterials as a novel therapeutic strategy for Alzheimer's disease: A comprehensive review	40
Interlinked role of ASN, TDP-43 and Miro1 with parkinopathy: Focus on targeted approach against neuropathy in parkinsonism	39
Poly (ADP-ribose) polymerase 1 and neurodegenerative diseases: Past, present, and future	39
Therapeutic potential of lipid nanosystems for the treatment of Parkinson’s disease	39
Modulating the polarization phenotype of microglia – A valuable strategy for central nervous system diseases	38