DNA Repair

Article	Citations
Spatial mapping of the DNA adducts in cancer	89
Functional defects of cancer-associated MDC1 mutations in DNA damage repair	84
Regulatory apoptotic fragment of PARP1 complements catalytic fragment for PAR and DNA-dependent activity but inhibits DNA-induced catalytic stimulation of PARP2	80
Suppressors of Blm-deficiency identify three novel proteins that facilitate DNA repair in Ustilago maydis	75
Active genome integrity	50
DNA polymerase λ Loop1 variant yields unexpected gain-of-function capabilities in nonhomologous end-joining	47
Building an integrated view of R-loops, transcription, and chromatin	46
Loss of an ABC transporter in Arabidopsis thaliana confers hypersensitivity to the anti-cancer drug bleomycin	45
Acetylation of H3K56 orchestrates UV-responsive chromatin events that generate DNA accessibility during Nucleotide Excision Repair	39
Editors’ note Penny Jeggo and Bennett Van Houten	37
Editorial Board	36
Harnessing R-loop dynamics: Challenging cancer therapy resistance	36
Single-molecule approaches for DNA damage detection and repair: A focus on Repair Assisted Damage Detection (RADD)	35
Single-molecule imaging of genome maintenance proteins encountering specific DNA sequences and structures	34
The burden of overweight: Higher body mass index, but not vital exhaustion, is associated with higher DNA damage and lower DNA repair capacity	34
From cooperation to conflicts – A complicated relationship between transcription and replication	32
The role of human PrimPol active site residue Gln48 in catalysis and complex formation with DNA	31
Stressed? Break-induced replication comes to the rescue!	31
Corruption of DNA end-joining in mammalian chromosomes by progerin expression	30
A novel Family V uracil DNA glycosylase from Sulfolobus islandicus REY15A	29
Irc20 modulates LOH frequency and distribution in S. cerevisiae	28
Editorial Board	27
PARP1-PROTACs providing novel opportunities in precision oncology by targeting DNA damage response	27
Editorial Board	26
Editorial Board	26

Comparing Mfd- and UvrD-dependent models of transcription coupled DNA repair in live Escherichia coli using single-molecule tracking	24
Targeting base excision repair in precision oncology	24
What are the DNA lesions underlying formaldehyde toxicity?	23
PARP inhibitors in ovarian cancer: Mechanisms of resistance and implications to therapy	23
DNA damage response and genomic instability disorder: Meeting report of the 20th Ataxia-Telangiectasia Workshop (ATW-2024) in conjunction with the 15th international symposium on DNA damage response &	22
rumAB genes from SXT/R391 ICEs confer UV-induced mutability to Proteus mirabilis hosts and improve conjugation after UV irradiation	22
DNA repair-related heritable photosensitivity syndromes: Mutation landscape in a multiethnic cohort of 17 multigenerational families with high degree of consanguinity	21
Chromatin meets the cytoskeleton: the importance of nuclear actin dynamics and associated motors for genome stability	21
Editorial Board	21
Positioning loss of PARP1 activity as the central toxic event in BRCA-deficient cancer	21
DNA synthesis across DNA hairpins by human PrimPol	20
The role of SLFN11 in DNA replication stress response and its implications for the Fanconi anemia pathway	20
The dark side of homology-directed repair	19
Phospho-SIM and exon8b of PML protein regulate formation of doxorubicin-induced rDNA-PML compartment	19
The interferon response at the intersection of genome integrity and innate immunity	19
Double-strand break repair and mis-repair in 3D	19
The differential roles of rad9 alternatively spliced forms in double- strand DNA break repair during Drosophila meiosis	19
Metazoan nuclear pore complexes in gene regulation and genome stability	18
Protein-protein interactions in the core nucleotide excision repair pathway	18
ADP-ribosylation of DNA and RNA	18
Loss of alkyladenine DNA glycosylase alters gene expression in the developing mouse brain and leads to reduced anxiety and improved memory	17
NBS1 binds directly to TOPBP1 via disparate interactions between the NBS1 BRCT1 domain and the TOPBP1 BRCT1 and BRCT2 domains	17
Mutagenic repair of a ZFN-induced double-strand break in yeast: Effects of cleavage site sequence and spacer size	17
Strand discrimination in DNA mismatch repair	17
Editorial Board	17
Damage-Net: A program for DNA repair meta-analysis identifies a network of novel repair genes that facilitate cancer evolution	17
Large dataset of octocoral mitochondrial genomes provides new insights into mt-mutS evolution and function	16
Variation in G-quadruplex sequence and topology differentially impacts human DNA polymerase fidelity	16
Long-range PCR as a tool for evaluating mitochondrial DNA damage: Principles, benefits, and limitations of the technique	16
Recent advances in γH2AX biomarker-based genotoxicity assays: A marker of DNA damage and repair	16
One-ended and two-ended breaks at nickase-broken replication forks	16
Expression of BRCA1, BRCA2, RAD51, and other DSB repair factors is regulated by CRL4WDR70	15
Sequence context effects of replication of Fapy•dG in three mutational hot spot sequences of the p53 gene in human cells	15
The multifaceted roles of the Ctf4 replisome hub in the maintenance of genome integrity	15
XPA is susceptible to proteolytic cleavage by cathepsin L during lysis of quiescent cells	15
Endogenous base damage as a driver of genomic instability in homologous recombination-deficient cancers	15
Using the safety scissors: DNA resection regulation at DNA double-strand breaks and telomeres	14
Cutting Edge Perspectives in genome maintenance X	14
Chromosomal single-strand break repair and neurological disease: Implications on transcription and emerging genomic tools	14
Yearly perspective from the Co-Editors in Chief	14
Camptothecin compromises transcription recovery and cell survival against cisplatin and ultraviolet irradiation regardless of transcription-coupled nucleotide excision repair	14
Centromere: A Trojan horse for genome stability	14
Inhibition of human DNA alkylation damage repair enzyme ALKBH2 by HIV protease inhibitor ritonavir	13
Altered pathways in Cockayne syndrome: Involvement of MAPK, PI3K-Akt, extracellular matrix, inflammation, and neuronal signaling	13
DNA polymerase delta Exo domain stabilizes mononucleotide microsatellites in human cells	13
Biochemical characterization and mutational analysis of a mismatch glycosylase from the hyperthermophilic euryarchaeon Thermococcus barophilus Ch5	13
miR-197-5p increases Doxorubicin-mediated anticancer cytotoxicity of HT1080 fibrosarcoma cells by decreasing drug efflux	13
TOPBP1 regulates resistance of gastric cancer to oxaliplatin by promoting transcription of PARP1	13
DNA glycosylase deficiency leads to decreased severity of lupus in the Polb-Y265C mouse model	13
The life and legacy of Sam Wilson (1939–2021)	13

miR-185–5p rewires cisplatin resistance by restoring miR-203a-3p expression via downregulation of SOX9	13
Somatic mutation patterns at Ig and Non-Ig Loci	13
Impairment of the non-catalytic subunit Dpb2 of DNA Pol ɛ results in increased involvement of Pol δ on the leading strand	13
Increased contribution of DNA polymerase delta to the leading strand replication in yeast with an impaired CMG helicase complex	12
Weaponizing CRISPR/Cas9 for selective elimination of cells with an aberrant genome	12
BRCA1 and BRCA2 in DNA damage and replication stress response: Insights into their functions, mechanisms, and implications for cancer treatment	12
Reversible association of ubiquitin with PCNA is important for template switching in S. cerevisiae	12
Editorial Board	11
Frailty, sex, and poverty are associated with DNA damage and repair in frail, middle-aged urban adults	11
Contents of previous 3 special issues in this series of perspectives	11
MicroRNAs and the DNA damage response: How is cell fate determined?	11
Editorial Board	11
Corrigendum to “Role of NEIL1 in genome maintenance” [DNA Repair 148 (2025) 103820]	11
The flap endonuclease-1 mediated maturation of Okazaki fragments is critical for the cellular tolerance to remdesivir	11
Multi-omic analysis of altered transcriptome and epigenetic signatures in the UV-induced DNA damage response	10
RNF4 prevents genomic instability caused by chronic DNA under-replication	10
Impact of DNA sequences on DNA ‘opening’ by the Rad4/XPC nucleotide excision repair complex	10
Genetic polymorphisms in DNA repair genes and hepatocellular carcinoma risk	10
C-terminal residues of DNA polymerase β and E3 ligase required for ubiquitin-linked proteolysis of oxidative DNA-protein crosslinks	10
Oncometabolite 2-hydroxyglutarate suppresses basal protein levels of DNA polymerase beta that enhances alkylating agent and PARG inhibition induced cytotoxicity	10
Small-molecule activator of SMUG1 enhances repair of pyrimidine lesions in DNA	9
TFIIH central activity in nucleotide excision repair to prevent disease	9
Remdesivir triphosphate is a valid substrate to initiate synthesis of DNA primers by human PrimPol	9
CometChip enables parallel analysis of multiple DNA repair activities	9
Mechanisms and regulation of replication fork reversal	9
Therapeutic targeting of mismatch repair proteins in triplet repeat expansion diseases	9
Presenilin-1, mutated in familial Alzheimer’s disease, maintains genome stability via a γ-secretase dependent way	9
A moving target for drug discovery: Structure activity relationship and many genome (de)stabilizing functions of the RAD52 protein	9
Determination of DNA lesion bypass using a ChIP-based assay	9
Obituary	8
Phosphorylation-dependent assembly of DNA damage response systems and the central roles of TOPBP1	8
Positive and negative regulators of RAD51/DMC1 in homologous recombination and DNA replication	8
Regulation of DNA damage-induced HLA class I presentation	8
Processes shaping cancer genomes – From mitotic defects to chromosomal rearrangements	8
Probing the structure and function of polymerase θ helicase-like domain	8
Mlh1 interacts with both Msh2 and Msh6 for recruitment during mismatch repair	8
Editorial Board	8
KBM-mediated interactions with KU80 promote cellular resistance to DNA replication stress in CHO cells	8
Incorporation of 5’,8-cyclo-2’deoxyadenosines by DNA repair polymerases via base excision repair	8
USP1 in regulation of DNA repair pathways	8
The mRNA tether model for activation-induced deaminase and its relevance for Ig somatic hypermutation and class switch recombination	8
Compartmentalization of the DNA damage response: Mechanisms and functions	7
Biochemical characterization and mutational studies of endonuclease Q from the hyperthermophilic euryarchaeon Thermococcus gammatolerans	7
Pold4 subunit of replicative polymerase δ promotes fork slowing at broken templates	7
Mouse Embryonic Fibroblasts Isolated From Nthl1 D227Y Knockin Mice Exhibit Defective DNA Repair and Increased Genome Instability	7
Low and high doses of ionizing radiation evoke discrete global (phospho)proteome responses	7
SMC-5/6 complex subunit NSE-1 plays a crucial role in meiosis and DNA repair in Caenorhabditis elegans	7
Cutting edge perspectives in genome maintenance XI	7
Genome integrity and inflammation in the nervous system	7
Corrigendum to “Quantitative assessment of HR and NHEJ activities via CRISPR/Cas9-induced oligodeoxynucleotide-mediated DSB repair” [DNA Repair 70 (2018) 67–71]	7
Screening of glycosylase activity on oxidative derivatives of methylcytosine: Pedobacter heparinus SMUG2 as a formylcytosine- and carboxylcytosine-DNA glycosylase	7
Variants in the first methionine of RAD51C are homologous recombination proficient due to an alternative start site	7
PARPs and ADP-ribosyl hydrolases in cancer therapy: From drug targets to biomarkers	7
The replication stress response: Mechanisms and functions	7
Why the ROS matters: One-electron oxidants focus DNA damage and repair on G-quadruplexes for gene regulation	7
DNA lesions that block transcription induce the death of Trypanosoma cruzi via ATR activation, which is dependent on the presence of R-loops	7
DONSON: Slding in 2 the limelight	7
Real-time single-molecule visualization using DNA curtains reveals the molecular mechanisms underlying DNA repair pathways	7
Emerging connections: Poly(ADP-ribose), FET proteins and RNA in the regulation of DNA damage condensates	7
Phylogenetic distribution, structural analysis and interaction of nucleotide excision repair proteins in cyanobacteria	7
Significance and limitations of the use of next-generation sequencing technologies for detecting mutational signatures	6
Errol Friedberg: A life in writing	6
Role of the multifunctional transcription factor TFII-I in DNA damage repair	6
Targeting Wee1 kinase as a therapeutic approach in Hematological Malignancies	6
DNA Repair Capacity for Personalizing Risk and Treatment Response − Assay Development and Optimization in Human Peripheral Blood Mononuclear Cells (PBMCs)	6
Editorial Board	6
Editorial Board	6
Editorial Board	6
LncRNA LINC01664 promotes cancer resistance through facilitating homologous recombination-mediated DNA repair	6
Temporal and spatial dynamics of DNA double-strand break repair centers	6
Single-molecule studies of helicases and translocases in prokaryotic genome-maintenance pathways	6
Discovery of KPT-6566 as STAG1/2 Inhibitor sensitizing PARP and NHEJ Inhibitors to suppress tumor cells growth in vitro	6
Structure, function and evolution of the HerA subfamily proteins	6
XRCC3 loss leads to midgestational embryonic lethality in mice	6
From rest to repair: Safeguarding genomic integrity in quiescent cells	6
Deletions initiated by the vaccinia virus TopIB protein in yeast	6
Transcription coupled base excision repair in mammalian cells: So little is known and so much to uncover	5
Replication initiation sites and zones in the mammalian genome: Where are they located and how are they defined?	5
APE1 is a master regulator of the ATR-/ATM-mediated DNA damage response	5
Multiple functions of PARP1 in the repair of DNA double strand breaks	5

Holding it together: DNA end synapsis during non-homologous end joining	5
The fast-growing business of Serine ADP-ribosylation	5
The roles of non-productive complexes of DNA repair proteins with DNA lesions	5
Reversal of histone H2B mono-ubiquitination is required for replication stress recovery	5
Structure and mechanism in non-homologous end joining	5
Three targets in one complex: A molecular perspective of TFIIH in cancer therapy	5
FBH1 and the replication stress response: Implications for genome stability and cancer development	5
Interaction of mitoxantrone with abasic sites - DNA strand cleavage and inhibition of apurinic/apyrimidinic endonuclease 1, APE1	5
Live cell single-molecule imaging to study DNA repair in human cells	5
The role of histone H3K36me3 writers, readers and erasers in maintaining genome stability	5
Determinants governing BRC function evaluated by mutational analysis of Brh2 in Ustilago maydis	5
The Sm core components of small nuclear ribonucleoproteins promote homologous recombination repair	5
Repair of genomic interstrand crosslinks	5
Editorial Board	5
C. elegans ribosomal protein S3 protects against H2O2-induced DNA damage and suppresses spontaneous mutations in yeast	5
Transcription-coupled DNA double-strand break repair	5
The biochemistry of the carcinogenic alcohol metabolite acetaldehyde	5
DNA damage repair (DDR) related prognostic risk model in multiple myeloma based on single-cell and bulk sequencing	5
Editorial Board	4
PARP1-mediated PARylation of TonEBP prevents R-loop–associated DNA damage	4
Global screening of base excision repair in nucleosome core particles	4
Phosphoregulation of the checkpoint kinase Mec1ATR	4
Compared to other NHEJ factors, DNA-PK protein and RNA levels are markedly increased in all higher primates, but not in prosimians or other mammals	4
Large-scale generation and phenotypic characterization of zebrafish CRISPR mutants of DNA repair genes	4
Functions of PMS2 and MLH1 important for regulation of divergent repeat-mediated deletions	4
DNA damage-induced sumoylation of Sp1 induces its interaction with RNF4 and degradation in S phase to remove 53BP1 from DSBs and permit HR	4
BCLAF1, a functional partner of BACH1, participates in DNA damage response	4
Live cell transcription-coupled nucleotide excision repair dynamics revisited	4
DNA repair pathways in the mitochondria	4
Multifunctional properties of Nej1XLF C-terminus promote end-joining and impact DNA double-strand break repair pathway choice	4
Histone and Chromatin Dynamics Facilitating DNA repair	4
To divide or not to divide? NAC8 (SOG1) as a key regulator of DNA damage response in barley (Hordeum vulgare L.)	4
The nucleotide excision repair proteins through the lens of molecular dynamics simulations	4
DNA polymerase δ: A single Pol31 polymorphism suppresses the strain background-specific lethality of Pol32 inactivation in Saccharomyces cerevisiae	4
UVSSA facilitates transcription-coupled repair of DNA interstrand crosslinks	4
Partial deletions of the autoregulatory C-terminal domain of Artemis and their effect on its nuclease activity	4
Histone lysine modifying enzymes and their critical roles in DNA double-strand break repair	4
The Ataxia-telangiectasia mutated (ATM) is the most important gene for repairing the DNA in Myelodysplastic Neoplasm	4
Joining of DNA breaks- interplay between DNA ligases and poly (ADP-ribose) polymerases	4
Kinome-wide screening uncovers a role for Bromodomain Protein 3 in DNA double-stranded break repair	4
Non-canonical function of nuclear PTEN and its implication on tumorigenesis	4
Editorial Board	4
Cockayne syndrome group B protein uses its DNA translocase activity to promote mitotic DNA synthesis	4
A-T neurodegeneration and DNA damage-induced transcriptional stress	4
Mechanism for R-loop formation remote from the transcription start site: Topological issues and possible facilitation by dissociation of RNA polymerase	4
Toxic R-loops: Cause or consequence of replication stress?	4
HOTAIR beyond repression: In protein degradation, inflammation, DNA damage response, and cell signaling	4
Cutting-edge perspectives in genomic maintenance VIII	4
Targeting DNA damage sensors for cancer therapy	4
The analysis of protein recruitment to laser microirradiation-induced DNA damage in live cells: Best practices for data analysis	4
The C-terminal tail of Rad17, iVERGE, binds the 9‒1‒1 complex independently of AAA+ ATPase domains to provide another clamp–loader interface	4
Bulk synthesis and beyond: The roles of eukaryotic replicative DNA polymerases	4
An open-source platform to quantify subnuclear foci and protein colocalization in response to replication stress	4
Monitoring DNA polymerase β mitochondrial localization and dynamics	4
The C-terminal domain of Arabidopsis ROS1 DNA demethylase interacts with histone H3 and is required for DNA binding and catalytic activity	3
Microglial inflammation in genome instability: A neurodegenerative perspective	3
Genomic stress and impaired DNA repair in Alzheimer disease	3
Checkpoint activation and recovery: regulation of the 9–1–1 axis by the PP2A phosphatase	3
Clinical evidence for a role of E2F1-induced replication stress in modulating tumor mutational burden and immune microenvironment	3
Rrp1, Rrp2 and Uls1 – Yeast SWI2/SNF2 DNA dependent translocases in genome stability maintenance	3
Cancer testis antigens and genomic instability: More than immunology	3
DNA topoisomerase IIß inhibition blocks DNA end resection and synergizes with PARPi in BRCA1-deficient models	3
Temporal recruitment of base excision DNA repair factors in living cells in response to different micro-irradiation DNA damage protocols	3
Histone variants: The unsung guardians of the genome	3
The evolving complexity of DNA damage foci: RNA, condensates and chromatin in DNA double-strand break repair	3
53BP1-the ‘Pandora’s box’ of genome integrity	3
‘From R-lupus to cancer’: Reviewing the role of R-loops in innate immune responses	3
Structure, function and evolution of the Helix-hairpin-Helix DNA glycosylase superfamily: Piecing together the evolutionary puzzle of DNA base damage repair mechanisms	3
Saccharomyces cerevisiae apurinic/apyrimidinic endonuclease 1 repairs abasic site-mediated DNA-peptide/protein cross-links	3
Editorial	3
Single-molecule toxicogenomics: Optical genome mapping of DNA-damage in nanochannel arrays	3
UBAP2/UBAP2L regulate UV-induced ubiquitylation of RNA polymerase II and are the human orthologues of yeast Def1	3
The DNA damage induced immune response: Implications for cancer therapy	3
O-GlcNAc transferase is important for homology-directed repair	3
Biochemical analysis of H2O2-induced mutation spectra revealed that multiple damages were involved in the mutational process	3
FAM21 interacts with Ku to promote the localization of WASH to DNA double strand break sites	3
Mediator complex in transcription regulation and DNA repair: Relevance for human diseases	3
Lawrence H. Thompson: A life of bikes, birds, and DNA repair (1941–2024)	3
Spontaneous and salt stress-induced molecular instability in the progeny of MSH7 deficient Arabidopsis thaliana plants	3
DNA repair deficiencies and neurodegeneration	3
Overexpression of the WWE domain of RNF146 modulates poly-(ADP)-ribose dynamics at sites of DNA damage	3
Unveiling cGAS mechanisms: Insights into DNA damage and immune sensing in cancer	3
Daughter-strand gaps in DNA replication – substrates of lesion processing and initiators of distress signalling	3
Evolution of the triplet BRCT domain	3
SMUG1 regulates fat homeostasis leading to a fatty liver phenotype in mice	3