DNA Repair

Article	Citations
Active genome integrity	50
Suppressors of Blm-deficiency identify three novel proteins that facilitate DNA repair in Ustilago maydis	45
Spatial mapping of the DNA adducts in cancer	43
Functional defects of cancer-associated MDC1 mutations in DNA damage repair	37
DNA polymerase λ Loop1 variant yields unexpected gain-of-function capabilities in nonhomologous end-joining	36
Regulatory apoptotic fragment of PARP1 complements catalytic fragment for PAR and DNA-dependent activity but inhibits DNA-induced catalytic stimulation of PARP2	36
Building an integrated view of R-loops, transcription, and chromatin	34
Editors’ note Penny Jeggo and Bennett Van Houten	32
Contents of previous 3 special issues in this series of perspectives	32
Single-molecule approaches for DNA damage detection and repair: A focus on Repair Assisted Damage Detection (RADD)	30
Harnessing R-loop dynamics: Challenging cancer therapy resistance	25
The role of human PrimPol active site residue Gln48 in catalysis and complex formation with DNA	24
Acetylation of H3K56 orchestrates UV-responsive chromatin events that generate DNA accessibility during Nucleotide Excision Repair	23
From cooperation to conflicts – A complicated relationship between transcription and replication	21
Single-molecule imaging of genome maintenance proteins encountering specific DNA sequences and structures	21
The burden of overweight: Higher body mass index, but not vital exhaustion, is associated with higher DNA damage and lower DNA repair capacity	21
Stressed? Break-induced replication comes to the rescue!	21
Irc20 modulates LOH frequency and distribution in S. cerevisiae	20
rumAB genes from SXT/R391 ICEs confer UV-induced mutability to Proteus mirabilis hosts and improve conjugation after UV irradiation	19
A novel Family V uracil DNA glycosylase from Sulfolobus islandicus REY15A	19
The B cell dilemma: Diversity or fidelity?	19
Editorial Board	17
Editorial Board	17
Editorial Board	17
Corruption of DNA end-joining in mammalian chromosomes by progerin expression	17

What are the DNA lesions underlying formaldehyde toxicity?	16
PARP1-PROTACs providing novel opportunities in precision oncology by targeting DNA damage response	16
Comparing Mfd- and UvrD-dependent models of transcription coupled DNA repair in live Escherichia coli using single-molecule tracking	16
Positioning loss of PARP1 activity as the central toxic event in BRCA-deficient cancer	16
DNA damage response and genomic instability disorder: Meeting report of the 20th Ataxia-Telangiectasia Workshop (ATW-2024) in conjunction with the 15th international symposium on DNA damage response &	16
PARP inhibitors in ovarian cancer: Mechanisms of resistance and implications to therapy	15
Targeting base excision repair in precision oncology	15
DNA synthesis across DNA hairpins by human PrimPol	15
Chromatin meets the cytoskeleton: the importance of nuclear actin dynamics and associated motors for genome stability	15
Protein-protein interactions in the core nucleotide excision repair pathway	14
Phospho-SIM and exon8b of PML protein regulate formation of doxorubicin-induced rDNA-PML compartment	14
The differential roles of rad9 alternatively spliced forms in double- strand DNA break repair during Drosophila meiosis	14
Double-strand break repair and mis-repair in 3D	14
Editorial Board	14
The interferon response at the intersection of genome integrity and innate immunity	14
The role of SLFN11 in DNA replication stress response and its implications for the Fanconi anemia pathway	14
DNA repair-related heritable photosensitivity syndromes: Mutation landscape in a multiethnic cohort of 17 multigenerational families with high degree of consanguinity	14
Metazoan nuclear pore complexes in gene regulation and genome stability	14
Camptothecin compromises transcription recovery and cell survival against cisplatin and ultraviolet irradiation regardless of transcription-coupled nucleotide excision repair	13
Using the safety scissors: DNA resection regulation at DNA double-strand breaks and telomeres	13
NBS1 binds directly to TOPBP1 via disparate interactions between the NBS1 BRCT1 domain and the TOPBP1 BRCT1 and BRCT2 domains	13
Long-range PCR as a tool for evaluating mitochondrial DNA damage: Principles, benefits, and limitations of the technique	13
The multifaceted roles of the Ctf4 replisome hub in the maintenance of genome integrity	13
Chromosomal single-strand break repair and neurological disease: Implications on transcription and emerging genomic tools	13
Loss of alkyladenine DNA glycosylase alters gene expression in the developing mouse brain and leads to reduced anxiety and improved memory	13
Centromere: A Trojan horse for genome stability	12
Endogenous base damage as a driver of genomic instability in homologous recombination-deficient cancers	12
Editorial Board	12
Large dataset of octocoral mitochondrial genomes provides new insights into mt-mutS evolution and function	12
XPA is susceptible to proteolytic cleavage by cathepsin L during lysis of quiescent cells	12
Variation in G-quadruplex sequence and topology differentially impacts human DNA polymerase fidelity	12
One-ended and two-ended breaks at nickase-broken replication forks	11
TOPBP1 regulates resistance of gastric cancer to oxaliplatin by promoting transcription of PARP1	11
Expression of BRCA1, BRCA2, RAD51, and other DSB repair factors is regulated by CRL4WDR70	11
miR-185–5p rewires cisplatin resistance by restoring miR-203a-3p expression via downregulation of SOX9	11
Cutting Edge Perspectives in genome maintenance X	10
Biochemical characterization and mutational analysis of a mismatch glycosylase from the hyperthermophilic euryarchaeon Thermococcus barophilus Ch5	10
Impairment of the non-catalytic subunit Dpb2 of DNA Pol ɛ results in increased involvement of Pol δ on the leading strand	10
Yearly perspective from the Co-Editors in Chief	10
Altered pathways in Cockayne syndrome: Involvement of MAPK, PI3K-Akt, extracellular matrix, inflammation, and neuronal signaling	10
Inhibition of human DNA alkylation damage repair enzyme ALKBH2 by HIV protease inhibitor ritonavir	10
Somatic mutation patterns at Ig and Non-Ig Loci	10
miR-197-5p increases Doxorubicin-mediated anticancer cytotoxicity of HT1080 fibrosarcoma cells by decreasing drug efflux	10
Increased contribution of DNA polymerase delta to the leading strand replication in yeast with an impaired CMG helicase complex	9
Frailty, sex, and poverty are associated with DNA damage and repair in frail, middle-aged urban adults	9
Editorial Board	9
Insight into meiotic DNA end resection: Mechanisms and regulation	9
BRCA1 and BRCA2 in DNA damage and replication stress response: Insights into their functions, mechanisms, and implications for cancer treatment	9
Reversible association of ubiquitin with PCNA is important for template switching in S. cerevisiae	9
C-terminal residues of DNA polymerase β and E3 ligase required for ubiquitin-linked proteolysis of oxidative DNA-protein crosslinks	9

Editorial Board	9
Presenilin-1, mutated in familial Alzheimer’s disease, maintains genome stability via a γ-secretase dependent way	9
Weaponizing CRISPR/Cas9 for selective elimination of cells with an aberrant genome	9
Corrigendum to “Role of NEIL1 in genome maintenance” [DNA Repair 148 (2025) 103820]	9
Contents of previous 3 special issues in this series of perspectives	9
Small-molecule activator of SMUG1 enhances repair of pyrimidine lesions in DNA	9
Obituary	8
RNF4 prevents genomic instability caused by chronic DNA under-replication	8
Mlh1 interacts with both Msh2 and Msh6 for recruitment during mismatch repair	8
The flap endonuclease-1 mediated maturation of Okazaki fragments is critical for the cellular tolerance to remdesivir	8
Mechanisms and regulation of replication fork reversal	8
Incorporation of 5’,8-cyclo-2’deoxyadenosines by DNA repair polymerases via base excision repair	8
A moving target for drug discovery: Structure activity relationship and many genome (de)stabilizing functions of the RAD52 protein	8
TFIIH central activity in nucleotide excision repair to prevent disease	8
USP1 in regulation of DNA repair pathways	8
Probing the structure and function of polymerase θ helicase-like domain	8
Regulation of DNA damage-induced HLA class I presentation	8
How DNA secondary structures drive replication fork instability	8
Oncometabolite 2-hydroxyglutarate suppresses basal protein levels of DNA polymerase beta that enhances alkylating agent and PARG inhibition induced cytotoxicity	8
Remdesivir triphosphate is a valid substrate to initiate synthesis of DNA primers by human PrimPol	8
The replication stress response: Mechanisms and functions	7
Positive and negative regulators of RAD51/DMC1 in homologous recombination and DNA replication	7
Mouse Embryonic Fibroblasts Isolated From Nthl1 D227Y Knockin Mice Exhibit Defective DNA Repair and Increased Genome Instability	7
Screening of glycosylase activity on oxidative derivatives of methylcytosine: Pedobacter heparinus SMUG2 as a formylcytosine- and carboxylcytosine-DNA glycosylase	7
Biochemical characterization and mutational studies of endonuclease Q from the hyperthermophilic euryarchaeon Thermococcus gammatolerans	7
Emerging connections: Poly(ADP-ribose), FET proteins and RNA in the regulation of DNA damage condensates	7
PARPs and ADP-ribosyl hydrolases in cancer therapy: From drug targets to biomarkers	7
Therapeutic targeting of mismatch repair proteins in triplet repeat expansion diseases	7
Cutting edge perspectives in genome maintenance XI	7
Variants in the first methionine of RAD51C are homologous recombination proficient due to an alternative start site	7
DONSON: Slding in 2 the limelight	7
Discovery of KPT-6566 as STAG1/2 Inhibitor sensitizing PARP and NHEJ Inhibitors to suppress tumor cells growth in vitro	7
The mRNA tether model for activation-induced deaminase and its relevance for Ig somatic hypermutation and class switch recombination	7
SMC-5/6 complex subunit NSE-1 plays a crucial role in meiosis and DNA repair in Caenorhabditis elegans	7
KBM-mediated interactions with KU80 promote cellular resistance to DNA replication stress in CHO cells	7
Low and high doses of ionizing radiation evoke discrete global (phospho)proteome responses	7
DNA lesions that block transcription induce the death of Trypanosoma cruzi via ATR activation, which is dependent on the presence of R-loops	7
Pold4 subunit of replicative polymerase δ promotes fork slowing at broken templates	7
Genome integrity and inflammation in the nervous system	7
Structure and mechanism in non-homologous end joining	6
The role of histone H3K36me3 writers, readers and erasers in maintaining genome stability	6
Replication initiation sites and zones in the mammalian genome: Where are they located and how are they defined?	6
Compartmentalization of the DNA damage response: Mechanisms and functions	6
DNA Repair Capacity for Personalizing Risk and Treatment Response − Assay Development and Optimization in Human Peripheral Blood Mononuclear Cells (PBMCs)	6
Structure, function and evolution of the HerA subfamily proteins	6
Reversal of histone H2B mono-ubiquitination is required for replication stress recovery	6
The biochemistry of the carcinogenic alcohol metabolite acetaldehyde	6
Errol Friedberg: A life in writing	6
DNA damage repair (DDR) related prognostic risk model in multiple myeloma based on single-cell and bulk sequencing	6
Real-time single-molecule visualization using DNA curtains reveals the molecular mechanisms underlying DNA repair pathways	6
Phylogenetic distribution, structural analysis and interaction of nucleotide excision repair proteins in cyanobacteria	6
Deletions initiated by the vaccinia virus TopIB protein in yeast	6
From rest to repair: Safeguarding genomic integrity in quiescent cells	6
LncRNA LINC01664 promotes cancer resistance through facilitating homologous recombination-mediated DNA repair	6
Editorial Board	6
Temporal and spatial dynamics of DNA double-strand break repair centers	6
Why the ROS matters: One-electron oxidants focus DNA damage and repair on G-quadruplexes for gene regulation	6
Editorial Board	6
Editorial Board	6
The fast-growing business of Serine ADP-ribosylation	5
Multiple functions of PARP1 in the repair of DNA double strand breaks	5
Holding it together: DNA end synapsis during non-homologous end joining	5
Editorial Board	5
Editorial Board	5
The roles of non-productive complexes of DNA repair proteins with DNA lesions	5
Interaction of mitoxantrone with abasic sites - DNA strand cleavage and inhibition of apurinic/apyrimidinic endonuclease 1, APE1	5
Determinants governing BRC function evaluated by mutational analysis of Brh2 in Ustilago maydis	5
Repair of genomic interstrand crosslinks	5
To divide or not to divide? NAC8 (SOG1) as a key regulator of DNA damage response in barley (Hordeum vulgare L.)	5
APE1 is a master regulator of the ATR-/ATM-mediated DNA damage response	5
Live cell single-molecule imaging to study DNA repair in human cells	5
Transcription-coupled DNA double-strand break repair	5
S-palmitoylation: An oily modification guardinggenome stability	5
FBH1 and the replication stress response: Implications for genome stability and cancer development	5
Mechanism for R-loop formation remote from the transcription start site: Topological issues and possible facilitation by dissociation of RNA polymerase	5
The Ataxia-telangiectasia mutated (ATM) is the most important gene for repairing the DNA in Myelodysplastic Neoplasm	4
The analysis of protein recruitment to laser microirradiation-induced DNA damage in live cells: Best practices for data analysis	4
The nucleotide excision repair proteins through the lens of molecular dynamics simulations	4
C. elegans ribosomal protein S3 protects against H2O2-induced DNA damage and suppresses spontaneous mutations in yeast	4
The C-terminal tail of Rad17, iVERGE, binds the 9‒1‒1 complex independently of AAA+ ATPase domains to provide another clamp–loader interface	4

Targeting DNA damage sensors for cancer therapy	4
Mediator complex in transcription regulation and DNA repair: Relevance for human diseases	4
Joining of DNA breaks- interplay between DNA ligases and poly (ADP-ribose) polymerases	4
DNA G-quadruplexes: Structural and functional insights	4
Functions of PMS2 and MLH1 important for regulation of divergent repeat-mediated deletions	4
Bulk synthesis and beyond: The roles of eukaryotic replicative DNA polymerases	4
UVSSA facilitates transcription-coupled repair of DNA interstrand crosslinks	4
BCLAF1, a functional partner of BACH1, participates in DNA damage response	4
DNA polymerase δ: A single Pol31 polymorphism suppresses the strain background-specific lethality of Pol32 inactivation in Saccharomyces cerevisiae	4
A-T neurodegeneration and DNA damage-induced transcriptional stress	4
Monitoring DNA polymerase β mitochondrial localization and dynamics	4
Histone variants: The unsung guardians of the genome	4
Global screening of base excision repair in nucleosome core particles	4
DNA repair pathways in the mitochondria	4
Editorial Board	4
Phosphoregulation of the checkpoint kinase Mec1ATR	4
Kinome-wide screening uncovers a role for Bromodomain Protein 3 in DNA double-stranded break repair	4
Modulation of OGG1 enzymatic activity by the cellular machinery – have all the boxes been ticked?	4
Cockayne syndrome group B protein uses its DNA translocase activity to promote mitotic DNA synthesis	4
Live cell transcription-coupled nucleotide excision repair dynamics revisited	4
DNA damage-induced sumoylation of Sp1 induces its interaction with RNF4 and degradation in S phase to remove 53BP1 from DSBs and permit HR	4
Partial deletions of the autoregulatory C-terminal domain of Artemis and their effect on its nuclease activity	4
Biochemical analysis of H2O2-induced mutation spectra revealed that multiple damages were involved in the mutational process	4
Multifunctional properties of Nej1XLF C-terminus promote end-joining and impact DNA double-strand break repair pathway choice	4
Recent advances in understanding the molecular mechanisms of SLX4 recruitment in the replication stress response	3
Contributions of DNA double strand break repair pathways to DNA crosslink repair	3
DNA topoisomerase IIß inhibition blocks DNA end resection and synergizes with PARPi in BRCA1-deficient models	3
Editorial	3
Polymerase theta: Genome protection through regulated deployment	3
The C-terminal domain of Arabidopsis ROS1 DNA demethylase interacts with histone H3 and is required for DNA binding and catalytic activity	3
‘From R-lupus to cancer’: Reviewing the role of R-loops in innate immune responses	3
53BP1-the ‘Pandora’s box’ of genome integrity	3
The DNA damage induced immune response: Implications for cancer therapy	3
UBAP2/UBAP2L regulate UV-induced ubiquitylation of RNA polymerase II and are the human orthologues of yeast Def1	3
Post-translational regulation of Tyrosyl-DNA phosphodiesterase (TDP1 and TDP2) for the repair of the trapped topoisomerase-DNA covalent complex	3
A bibliometric analysis of research on R-loop: Landscapes, highlights and trending topics	3
Saccharomyces cerevisiae apurinic/apyrimidinic endonuclease 1 repairs abasic site-mediated DNA-peptide/protein cross-links	3
Spontaneous and salt stress-induced molecular instability in the progeny of MSH7 deficient Arabidopsis thaliana plants	3
Lawrence H. Thompson: A life of bikes, birds, and DNA repair (1941–2024)	3
How to write an ending: Telomere replication as a multistep process	3
Temporal recruitment of base excision DNA repair factors in living cells in response to different micro-irradiation DNA damage protocols	3
Microglial inflammation in genome instability: A neurodegenerative perspective	3
FAM21 interacts with Ku to promote the localization of WASH to DNA double strand break sites	3
Compared to other NHEJ factors, DNA-PK protein and RNA levels are markedly increased in all higher primates, but not in prosimians or other mammals	3
A tale of two mechanisms: Clarification of the pathway for MBD4 catalyzed glycosidic bond cleavage using MD and QM/MM calculations	3
Overexpression of the WWE domain of RNF146 modulates poly-(ADP)-ribose dynamics at sites of DNA damage	3
DNA repair deficiencies and neurodegeneration	3
Clinical evidence for a role of E2F1-induced replication stress in modulating tumor mutational burden and immune microenvironment	3
Spatio-temporal dynamics of the DNA glycosylase OGG1 in finding and processing 8-oxoguanine	3
Rrp1, Rrp2 and Uls1 – Yeast SWI2/SNF2 DNA dependent translocases in genome stability maintenance	3
Single-molecule toxicogenomics: Optical genome mapping of DNA-damage in nanochannel arrays	3
Evolution of the triplet BRCT domain	3
SMUG1 regulates fat homeostasis leading to a fatty liver phenotype in mice	3
Genomic stress and impaired DNA repair in Alzheimer disease	3
Unveiling cGAS mechanisms: Insights into DNA damage and immune sensing in cancer	3
O-GlcNAc transferase is important for homology-directed repair	3
FBH1 deficiency sensitizes cells to WEE1 inhibition by promoting mitotic catastrophe	3
Checkpoint activation and recovery: regulation of the 9–1–1 axis by the PP2A phosphatase	3
DNA damage response inhibitors in cancer therapy: Mechanisms, clinical development, and combination strategies	2
Initiation of base excision repair is modulated by nucleosome occupancy modifying sequences	2
Editors’ note on “p21CDKN1A participates in base excision repair by regulating the activity of poly(ADP-ribose) polymerase-1”	2
Transcription reprogramming and endogenous DNA damage	2
Species variations in XRCC1 recruitment strategies for FHA domain-containing proteins	2
Divergent structures of Mammalian and gammaherpesvirus uracil DNA glycosylases confer distinct DNA binding and substrate activity	2
The HPF1-dependent histone PARylation catalyzed by PARP2 is specifically stimulated by an incised AP site-containing BER DNA intermediate	2
The multifaceted functions of homologous recombination in dealing with replication-associated DNA damages	2
Replication stress drives chromosomal instability in fibroblasts of childhood cancer survivors with second primary neoplasms	2
Intersection of the fragile X-related disorders and the DNA damage response	2
The impact of chromatin on double-strand break repair: Imaging tools and discoveries	2
How RNA impacts DNA repair	2
The interactions between DNA methylation machinery and long non-coding RNAs in tumor progression and drug resistance	2
The model moss Physcomitrium patens relies heavily on homologous recombination to repair DNA double-strand breaks	2
PARP enzyme synthesis of protein-free poly(ADP-ribose): Implications for DNA damage signaling and repair	2
Mechanisms of tandem duplication in the cancer genome	2
The role of DNA repair deficiency in lipid accumulation: A proof-of-concept study	2
Editorial Board	2
Differential ETS1 binding to T:G mismatches within a CpG dinucleotide contributes to C-to-T somatic mutation rate of the IDH2 hotspot at codon Arg140	2
Efficient activity of uracil DNA glycosylase (UNG2) in proliferating cells requires binding to proliferating cell nuclear antigen (PCNA) and replication protein A (RPA)	2
Facile preparation of model DNA interstrand cross-link repair intermediates using ribonucleotide-containing DNA	2
Cloning and characterization of the major AP endonuclease from Staphylococcus aureus	2
NEIL3 promotes cell proliferation of ccRCC via the cyclin D1-Rb-E2F1 feedback loop regulation	2
Mechanistic insights into RAD51-mediated nucleosome binding and remodeling in homologous recombination	2
Genome organization and stability in mammalian pre-implantation development	2
Helicase activities of Rad5 and Rrm3 genetically interact in the prevention of recombinogenic DNA lesions in Saccharomyces cerevisiae	2
The HNH endonuclease domain of the giant virus MutS7 specifically binds to branched DNA structures with single-stranded regions	2
Editorial Board	2
Development and characterization of a novel NEIL1 nanobody	2
Synergistic effects on mutagenicity of tandem lesions containing 8-oxo-7,8-dihydro-2′-deoxyguanosine or Fapy•dG flanked by a 3′ 5-formyl-2′-deoxyuridine in human cells	2
Super-resolution GSDIM microscopy unveils distinct nanoscale characteristics of DNA repair foci under diverse genotoxic stress	2
Editorial Board	2
The DHX9 helicase interacts with human DNA polymerase δ4 and stimulates its activity in D-loop extension synthesis	2
Regulation, functional impact, and therapeutic targeting of APOBEC3A in cancer	2
Ku80 is indispensable for repairing DNA double-strand breaks at highly methylated sites in human HCT116 cells	2
DLG2 impairs dsDNA break repair and maintains genome integrity in neuroblastoma	2
New twists to the ALTernative endings at telomeres	2