DNA Repair

Article	Citations
To divide or not to divide? NAC8 (SOG1) as a key regulator of DNA damage response in barley (Hordeum vulgare L.)	77
Editorial Board	74
The nucleotide excision repair proteins through the lens of molecular dynamics simulations	71
Suppressors of Blm-deficiency identify three novel proteins that facilitate DNA repair in Ustilago maydis	70
Catalytic activity of OGG1 is impaired by Zinc deficiency	54
Structural features of DNA polymerases β and λ in complex with benzo[a]pyrene-adducted DNA cause a difference in lesion tolerance	47
The Eyes Absent family: At the intersection of DNA repair, mitosis, and replication	43
Editorial Board	41
The role of DNA damage response in chemo- and radio-resistance of cancer cells: Can DDR inhibitors sole the problem?	41
Editorial Board	39
The life and legacy of Sam Wilson (1939–2021)	34
Chemopotentiating effects of low-dose fractionated radiation on cisplatin and paclitaxel in cervix cancer cell lines and normal fibroblasts from patients with cervix cancer	34
Editorial Board	33
Mechanism for R-loop formation remote from the transcription start site: Topological issues and possible facilitation by dissociation of RNA polymerase	31
Editorial Board	30
Editorial Board	30
From fluorescent foci to sequence: Illuminating DNA double strand break repair by high-throughput sequencing technologies	29
Editors’ Note	28
Cutting-edge Perspectives in Genome Maintenance IX	28
Editorial Board	28
Editorial Board	26
Editorial Board	25
C. elegans ribosomal protein S3 protects against H2O2-induced DNA damage and suppresses spontaneous mutations in yeast	25
The ataxia-telangiectasia mutated gene product regulates the cellular acid-labile sulfide fraction	23
Cockayne syndrome group B protein uses its DNA translocase activity to promote mitotic DNA synthesis	23

DNA polymerase δ: A single Pol31 polymorphism suppresses the strain background-specific lethality of Pol32 inactivation in Saccharomyces cerevisiae	22
Functional defects of cancer-associated MDC1 mutations in DNA damage repair	21
Histone variants H3.3 and H2A.Z/H3.3 facilitate excision of uracil from nucleosome core particles	21
Toxic R-loops: Cause or consequence of replication stress?	21
Cyclin-dependent kinase inhibitors (CDKIs) and the DNA damage response: The link between signaling pathways and cancer	21
Active genome integrity	21
Spatial mapping of the DNA adducts in cancer	20
Human translesion DNA polymerases ι and κ mediate tolerance to temozolomide in MGMT-deficient glioblastoma cells.	19
NEIL3: A unique DNA glycosylase involved in interstrand DNA crosslink repair	19
How DNA damage and non-canonical nucleotides alter the telomerase catalytic cycle	19
Cdc48/p97 segregase: Spotlight on DNA-protein crosslinks	19
Heterogeneity of DNA damage incidence and repair in different chromatin contexts	18
Loss of an ABC transporter in Arabidopsis thaliana confers hypersensitivity to the anti-cancer drug bleomycin	18
Increased contribution of DNA polymerase delta to the leading strand replication in yeast with an impaired CMG helicase complex	18
Species variations in XRCC1 recruitment strategies for FHA domain-containing proteins	17
The RNF8 and RNF168 Ubiquitin Ligases Regulate Pro- and Anti-Resection Activities at Broken DNA Ends During Non-Homologous End Joining	17
A novel role for Mms2 in the control of spontaneous mutagenesis and Pol3 abundance	17
BCLAF1, a functional partner of BACH1, participates in DNA damage response	17
Impacts of chromatin dynamics and compartmentalization on DNA repair	17
Synergistic effects on mutagenicity of tandem lesions containing 8-oxo-7,8-dihydro-2′-deoxyguanosine or Fapy•dG flanked by a 3′ 5-formyl-2′-deoxyuridine in human cells	17
Histone and Chromatin Dynamics Facilitating DNA repair	17
Transcription and genome integrity	17
MicroRNAs and the DNA damage response: How is cell fate determined?	17
Mechanistic insights from high resolution DNA damage analysis to understand mixed radiation exposure	16
UV light-induced dual promoter mutations dismantle the telomeric guardrails in melanoma	16
The role of rRNA in maintaining genome stability	16
Transcription reprogramming and endogenous DNA damage	16
DNA polymerase λ Loop1 variant yields unexpected gain-of-function capabilities in nonhomologous end-joining	16
Frailty, sex, and poverty are associated with DNA damage and repair in frail, middle-aged urban adults	15
PARP1-mediated PARylation of TonEBP prevents R-loop–associated DNA damage	15
Mitochondrial apurinic/apyrimidinic endonuclease Apn1 is not critical for the completion of the Plasmodium berghei life cycle	15
Helicase activities of Rad5 and Rrm3 genetically interact in the prevention of recombinogenic DNA lesions in Saccharomyces cerevisiae	15
Revisiting the BRCA-pathway through the lens of replication gap suppression	14
A-T neurodegeneration and DNA damage-induced transcriptional stress	14
Regulatory apoptotic fragment of PARP1 complements catalytic fragment for PAR and DNA-dependent activity but inhibits DNA-induced catalytic stimulation of PARP2	14
The FAcilitates Chromatin Transcription (FACT) complex: Its roles in DNA repair and implications for cancer therapy	14
Defects in DNA damage responses in SWI/SNF mutant cells and their impact on immune responses	14
The hidden elephant: Modified abasic sites and their consequences	14
Timely upstream events regulating nucleotide excision repair by ubiquitin-proteasome system: ubiquitin guides the way	14
USP13 regulates the replication stress response by deubiquitinating TopBP1	13
Live cell transcription-coupled nucleotide excision repair dynamics revisited	13
A moving target for drug discovery: Structure activity relationship and many genome (de)stabilizing functions of the RAD52 protein	13
Novel insights into bulky DNA damage formation and nucleotide excision repair from high-resolution genomics	13
PARP1: Structural insights and pharmacological targets for inhibition	13
Divergent structures of Mammalian and gammaherpesvirus uracil DNA glycosylases confer distinct DNA binding and substrate activity	13
Editorial Board	12
Potential cGAS-STING pathway functions in DNA damage responses, DNA replication and DNA repair	12
The Shu complex is an ATPase that regulates Rad51 filaments during homologous recombination in the DNA damage response	12
The burden of overweight: Higher body mass index, but not vital exhaustion, is associated with higher DNA damage and lower DNA repair capacity	12
Bulk synthesis and beyond: The roles of eukaryotic replicative DNA polymerases	12

Editorial Board	12
Editorial Board	12
Functions of PMS2 and MLH1 important for regulation of divergent repeat-mediated deletions	12
Genetic polymorphisms in DNA repair genes and hepatocellular carcinoma risk	11
Editorial Board	11
Editorial Board	11
Editors’ note on “p21CDKN1A participates in base excision repair by regulating the activity of poly(ADP-ribose) polymerase-1”	11
Acetylation of H3K56 orchestrates UV-responsive chromatin events that generate DNA accessibility during Nucleotide Excision Repair	11
Multifunctional properties of Nej1XLF C-terminus promote end-joining and impact DNA double-strand break repair pathway choice	10
Presenilin-1, mutated in familial Alzheimer’s disease, maintains genome stability via a γ-secretase dependent way	10
Editorial Board	10
Monitoring DNA polymerase β mitochondrial localization and dynamics	10
Editorial Board	10
Contents of previous 3 special issues in this series of perspectives	10
The C-terminal tail of Rad17, iVERGE, binds the 9‒1‒1 complex independently of AAA+ ATPase domains to provide another clamp–loader interface	10
Editorial Board	10
Editorial Board	10
Contents of previous 3 special issues in this series of perspectives	10
The N-terminal domain of uracil-DNA glycosylase: Roles for disordered regions	9
HOTAIR beyond repression: In protein degradation, inflammation, DNA damage response, and cell signaling	9
An open-source platform to quantify subnuclear foci and protein colocalization in response to replication stress	9
Single-molecule imaging of genome maintenance proteins encountering specific DNA sequences and structures	9
CST in maintaining genome stability: Beyond telomeres	9
Impact of DNA sequences on DNA ‘opening’ by the Rad4/XPC nucleotide excision repair complex	9
Plasmodium Ape1 is a multifunctional enzyme in mitochondrial base excision repair and is required for efficient transition from liver to blood stage infection	9
Multi-scale cellular imaging of DNA double strand break repair	9
RNA helicase, DDX3X, is actively recruited to sites of DNA damage in live cells	9
Chaperoning histones at the DNA repair dance	8
Paradoxical role of the major DNA repair protein, OGG1, in action-at-a-distance mutation induction by 8-oxo-7,8-dihydroguanine	8
Phosphoregulation of the checkpoint kinase Mec1ATR	8
DEF1: Much more than an RNA polymerase degradation factor	8
Replication dependent and independent mechanisms of GAA repeat instability	8
DNA damage-induced sumoylation of Sp1 induces its interaction with RNF4 and degradation in S phase to remove 53BP1 from DSBs and permit HR	8
Modulation of immune responses by DNA damage signaling	8
Oncometabolite 2-hydroxyglutarate suppresses basal protein levels of DNA polymerase beta that enhances alkylating agent and PARG inhibition induced cytotoxicity	8
CometChip enables parallel analysis of multiple DNA repair activities	8
Non-canonical function of nuclear PTEN and its implication on tumorigenesis	8
Histone lysine modifying enzymes and their critical roles in DNA double-strand break repair	8
UVSSA facilitates transcription-coupled repair of DNA interstrand crosslinks	8
Exploring factors influencing choice of DNA double-strand break repair pathways	7
Single-molecule approaches for DNA damage detection and repair: A focus on Repair Assisted Damage Detection (RADD)	7
UvrD-like helicase Hmi1 Has an ATP independent role in yeast mitochondrial DNA maintenance	7
Fanconi anemia and Aldehyde Degradation Deficiency Syndrome: Metabolism and DNA repair protect the genome and hematopoiesis from endogenous DNA damage	7
The roles of TonEBP in the DNA damage response: From DNA damage bypass to R-loop resolution	7
Kinome-wide screening uncovers a role for Bromodomain Protein 3 in DNA double-stranded break repair	7
The analysis of protein recruitment to laser microirradiation-induced DNA damage in live cells: Best practices for data analysis	7
DNA-PK: A synopsis beyond synapsis	6
Coping with RNA damage with a focus on APE1, a BER enzyme at the crossroad between DNA damage repair and RNA processing/decay	6
Small-molecule activator of SMUG1 enhances repair of pyrimidine lesions in DNA	6
Transient HR enhancement by RAD51-stimulatory compound confers protection on intestinal rather than hematopoietic tissue against irradiation in mice	6
Tolerating DNA damage by repriming: Gap filling in the spotlight	6
The interactions between DNA methylation machinery and long non-coding RNAs in tumor progression and drug resistance	6
Hydroxychloroquine induces oxidative DNA damage and mutation in mammalian cells	6
Finding significance: New perspectives in variant classification of the RAD51 regulators, BRCA2 and beyond	6
The flap endonuclease-1 mediated maturation of Okazaki fragments is critical for the cellular tolerance to remdesivir	6
The Ataxia-telangiectasia mutated (ATM) is the most important gene for repairing the DNA in Myelodysplastic Neoplasm	6
C-terminal residues of DNA polymerase β and E3 ligase required for ubiquitin-linked proteolysis of oxidative DNA-protein crosslinks	6
TFIIH central activity in nucleotide excision repair to prevent disease	6
Multi-omic analysis of altered transcriptome and epigenetic signatures in the UV-induced DNA damage response	6
Mechanisms of tandem duplication in the cancer genome	6
Dominant roles of BRCA1 in cellular tolerance to a chain-terminating nucleoside analog, alovudine	6
DNA repair gene polymorphisms and chromosomal aberrations in healthy, nonsmoking population	6
DNA repair pathways in the mitochondria	6
Global screening of base excision repair in nucleosome core particles	6
RNF4 prevents genomic instability caused by chronic DNA under-replication	6
Mechanisms of genome stability maintenance during cell division	6
Large-scale generation and phenotypic characterization of zebrafish CRISPR mutants of DNA repair genes	6
Kinetics model of DNA double-strand break repair in eukaryotes	5
Effect of mismatch repair on the mutational footprint of the bacterial SOS mutator activity	5
Transcription-coupled repair and the transcriptional response to UV-Irradiation	5
Targeted nuclear irradiation with a proton microbeam induces oxidative DNA base damage and triggers the recruitment of DNA glycosylases OGG1 and NTH1	5
Mechanisms and regulation of replication fork reversal	5
‘From R-lupus to cancer’: Reviewing the role of R-loops in innate immune responses	5
Phosphorylation-dependent assembly of DNA damage response systems and the central roles of TOPBP1	5
KBM-mediated interactions with KU80 promote cellular resistance to DNA replication stress in CHO cells	5
Understanding the DNA double-strand break repair and its therapeutic implications	5
DNA damage response and PD-1/PD-L1 pathway in ovarian cancer	5
Biochemical analysis of H2O2-induced mutation spectra revealed that multiple damages were involved in the mutational process	5
53BP1-the ‘Pandora’s box’ of genome integrity	5
Irc20 modulates LOH frequency and distribution in S. cerevisiae	5

Functional characterization of single nucleotide polymorphic variants of DNA repair enzyme NEIL1 in South Asian populations	5
Error-prone bypass patch by a low-fidelity variant of DNA polymerase zeta in human cells	5
How RNA impacts DNA repair	5
Targeting mitotic regulators in cancer as a strategy to enhance immune recognition	5
Microglial inflammation in genome instability: A neurodegenerative perspective	5
Processes shaping cancer genomes – From mitotic defects to chromosomal rearrangements	5
Single-molecule analysis of purified proteins and nuclear extracts: Insights from 8-oxoguanine glycosylase 1	5
What are the DNA lesions underlying formaldehyde toxicity?	5
A non-canonical nucleotide from viral genomes interferes with the oxidative DNA damage repair system	5
WITHDRAWN: Melatonin increases doxorubicin-induced apoptosis via oxidative DNA damage in oral squamous cell carcinoma	5
Mediator complex in transcription regulation and DNA repair: Relevance for human diseases	5
Stressed? Break-induced replication comes to the rescue!	5
Positive and negative regulators of RAD51/DMC1 in homologous recombination and DNA replication	5
Incorporation of 5’,8-cyclo-2’deoxyadenosines by DNA repair polymerases via base excision repair	5
Molecular dynamics simulations reveal how H3K56 acetylation impacts nucleosome structure to promote DNA exposure for lesion sensing	5
Cutting-edge perspectives in genomic maintenance VIII	4
Editorial Board	4
Polymorphic variant Asp239Tyr of human DNA glycosylase NTHL1 is inactive for removal of a variety of oxidatively-induced DNA base lesions from genomic DNA	4
A redox-sensitive iron-sulfur cluster in murine FAM72A controls its ability to degrade the nuclear form of uracil-DNA glycosylase	4
Interaction of Wwox with Brca1 and associated complex proteins prevents premature resection at double-strand breaks and aberrant homologous recombination	4
To indel or not to indel: Factors influencing mutagenesis during chromosomal break end joining	4
The HPF1-dependent histone PARylation catalyzed by PARP2 is specifically stimulated by an incised AP site-containing BER DNA intermediate	4
Remdesivir triphosphate is a valid substrate to initiate synthesis of DNA primers by human PrimPol	4
Role of the nucleotide excision repair pathway proteins (UvrB and UvrD2) in recycling UdgB, a base excision repair enzyme in Mycobacterium smegmatis	4
Editorial Board	4
Comparing Mfd- and UvrD-dependent models of transcription coupled DNA repair in live Escherichia coli using single-molecule tracking	4
Probing the structure and function of polymerase θ helicase-like domain	4
The interplay between chromatin remodeling and DNA double-strand break repair: Implications for cancer biology and therapeutics	4
Imaging the cellular response to an antigen tagged interstrand crosslinking agent	4
O-GlcNAc transferase is important for homology-directed repair	4
rumAB genes from SXT/R391 ICEs confer UV-induced mutability to Proteus mirabilis hosts and improve conjugation after UV irradiation	4
Differential ETS1 binding to T:G mismatches within a CpG dinucleotide contributes to C-to-T somatic mutation rate of the IDH2 hotspot at codon Arg140	4
Fluorescently labeled human apurinic/apyrimidinic endonuclease APE1 reveals effects of DNA polymerase β on the APE1–DNA interaction	4
SMUG1 regulates fat homeostasis leading to a fatty liver phenotype in mice	4
Editorial Board	4
Super-resolution GSDIM microscopy unveils distinct nanoscale characteristics of DNA repair foci under diverse genotoxic stress	4
Obituary	4
USP1 in regulation of DNA repair pathways	4
The DHX9 helicase interacts with human DNA polymerase δ4 and stimulates its activity in D-loop extension synthesis	4
Recognition and removal of clustered DNA lesions via nucleotide excision repair	4
Post-translational modification of factors involved in homologous recombination	4
Determination of DNA lesion bypass using a ChIP-based assay	4
Regulation of DNA damage-induced HLA class I presentation	4
Editorial Board	4
A homogeneous fluorescence assay for rapid and sensitive quantification of the global level of abasic sites in genomic DNA	4
Roles of phosphatases in eukaryotic DNA replication initiation control	3
Cell cycle-dependent radiosensitivity in mouse zygotes	3
Therapeutic targeting of mismatch repair proteins in triplet repeat expansion diseases	3
Increased DNA repair capacity augments resistance of glioblastoma cells to photodynamic therapy	3
The rate of formation and stability of abasic site interstrand crosslinks in the DNA duplex	3
A novel Family V uracil DNA glycosylase from Sulfolobus islandicus REY15A	3
Editorial Board	3
Partial deletions of the autoregulatory C-terminal domain of Artemis and their effect on its nuclease activity	3
FANCM branchpoint translocase: Master of traverse, reverse and adverse DNA repair	3
Double-strand break repair and mis-repair in 3D	3
Genome organization and stability in mammalian pre-implantation development	3
Replication initiation: Implications in genome integrity	3
DNA damage response and repair in osteosarcoma: Defects, regulation and therapeutic implications	3
FAM21 interacts with Ku to promote the localization of WASH to DNA double strand break sites	3
Role of histone acetyltransferases MOF and Tip60 in genome stability	3
Histone variants: The unsung guardians of the genome	3
Mlh1 interacts with both Msh2 and Msh6 for recruitment during mismatch repair	3
Corruption of DNA end-joining in mammalian chromosomes by progerin expression	3
DNA glycosylases for 8-oxoguanine repair in Staphylococcus aureus	3
The effect of methylation and hydroxymethylation of cytosine on activity and fidelity of Pol λ and Pol β	3
ADP-ribosylation of DNA and RNA	3
Low and high doses of ionizing radiation evoke discrete global (phospho)proteome responses	3
DNA-PK inhibitor AZD7648 is a more portent radiosensitizer than PARP inhibitor Olaparib in BRCA1/2 deficient tumors	3
The evolving complexity of DNA damage foci: RNA, condensates and chromatin in DNA double-strand break repair	3
Shining light on single-strand lesions caused by the chemotherapy drug bleomycin	3
Targeting dePARylation in cancer therapy	3
The DNA damage induced immune response: Implications for cancer therapy	3
Genomic stress and impaired DNA repair in Alzheimer disease	3
Methylation and hydroxymethylation of cytosine alter activity and fidelity of translesion DNA polymerases	3
Compared to other NHEJ factors, DNA-PK protein and RNA levels are markedly increased in all higher primates, but not in prosimians or other mammals	3
Editorial Board	3
Chromatin meets the cytoskeleton: the importance of nuclear actin dynamics and associated motors for genome stability	3
Defining R-loop classes and their contributions to genome instability	3
Positioning loss of PARP1 activity as the central toxic event in BRCA-deficient cancer	3
DNA mismatch repair controls the mutagenicity of Polymerase ζ-dependent translesion synthesis at methylated guanines	3