DNA Repair

Article	Citations
Active genome integrity	84
Suppressors of Blm-deficiency identify three novel proteins that facilitate DNA repair in Ustilago maydis	53
Building an integrated view of R-loops, transcription, and chromatin	43
Spatial mapping of the DNA adducts in cancer	42
Regulatory apoptotic fragment of PARP1 complements catalytic fragment for PAR and DNA-dependent activity but inhibits DNA-induced catalytic stimulation of PARP2	41
DNA polymerase λ Loop1 variant yields unexpected gain-of-function capabilities in nonhomologous end-joining	41
Functional defects of cancer-associated MDC1 mutations in DNA damage repair	37
Editors’ note Penny Jeggo and Bennett Van Houten	35
Harnessing R-loop dynamics: Challenging cancer therapy resistance	35
From cooperation to conflicts – A complicated relationship between transcription and replication	33
The role of human PrimPol active site residue Gln48 in catalysis and complex formation with DNA	32
The burden of overweight: Higher body mass index, but not vital exhaustion, is associated with higher DNA damage and lower DNA repair capacity	31
Single-molecule approaches for DNA damage detection and repair: A focus on Repair Assisted Damage Detection (RADD)	31
Acetylation of H3K56 orchestrates UV-responsive chromatin events that generate DNA accessibility during Nucleotide Excision Repair	31
Editorial Board	30
Single-molecule imaging of genome maintenance proteins encountering specific DNA sequences and structures	30
Stressed? Break-induced replication comes to the rescue!	29
Irc20 modulates LOH frequency and distribution in S. cerevisiae	28
Comparing Mfd- and UvrD-dependent models of transcription coupled DNA repair in live Escherichia coli using single-molecule tracking	26
Editorial Board	26
rumAB genes from SXT/R391 ICEs confer UV-induced mutability to Proteus mirabilis hosts and improve conjugation after UV irradiation	25
Editorial Board	22
Editorial Board	22
The B cell dilemma: Diversity or fidelity?	22
A novel Family V uracil DNA glycosylase from Sulfolobus islandicus REY15A	22

Targeting base excision repair in precision oncology	21
PARP inhibitors in ovarian cancer: Mechanisms of resistance and implications to therapy	20
What are the DNA lesions underlying formaldehyde toxicity?	20
PARP1-PROTACs providing novel opportunities in precision oncology by targeting DNA damage response	20
Positioning loss of PARP1 activity as the central toxic event in BRCA-deficient cancer	20
Corruption of DNA end-joining in mammalian chromosomes by progerin expression	19
DNA synthesis across DNA hairpins by human PrimPol	19
DNA damage response and genomic instability disorder: Meeting report of the 20th Ataxia-Telangiectasia Workshop (ATW-2024) in conjunction with the 15th international symposium on DNA damage response &	19
The role of SLFN11 in DNA replication stress response and its implications for the Fanconi anemia pathway	19
Chromatin meets the cytoskeleton: the importance of nuclear actin dynamics and associated motors for genome stability	19
The differential roles of rad9 alternatively spliced forms in double- strand DNA break repair during Drosophila meiosis	18
Double-strand break repair and mis-repair in 3D	17
Protein-protein interactions in the core nucleotide excision repair pathway	17
Phospho-SIM and exon8b of PML protein regulate formation of doxorubicin-induced rDNA-PML compartment	16
Metazoan nuclear pore complexes in gene regulation and genome stability	16
Endogenous base damage as a driver of genomic instability in homologous recombination-deficient cancers	15
Editorial Board	15
Long-range PCR as a tool for evaluating mitochondrial DNA damage: Principles, benefits, and limitations of the technique	15
DNA repair-related heritable photosensitivity syndromes: Mutation landscape in a multiethnic cohort of 17 multigenerational families with high degree of consanguinity	15
Using the safety scissors: DNA resection regulation at DNA double-strand breaks and telomeres	15
The interferon response at the intersection of genome integrity and innate immunity	15
One-ended and two-ended breaks at nickase-broken replication forks	14
Centromere: A Trojan horse for genome stability	14
Mutagenic repair of a ZFN-induced double-strand break in yeast: Effects of cleavage site sequence and spacer size	14
XPA is susceptible to proteolytic cleavage by cathepsin L during lysis of quiescent cells	14
Large dataset of octocoral mitochondrial genomes provides new insights into mt-mutS evolution and function	14
Sequence context effects of replication of Fapy•dG in three mutational hot spot sequences of the p53 gene in human cells	14
The multifaceted roles of the Ctf4 replisome hub in the maintenance of genome integrity	14
Camptothecin compromises transcription recovery and cell survival against cisplatin and ultraviolet irradiation regardless of transcription-coupled nucleotide excision repair	14
Loss of alkyladenine DNA glycosylase alters gene expression in the developing mouse brain and leads to reduced anxiety and improved memory	14
Expression of BRCA1, BRCA2, RAD51, and other DSB repair factors is regulated by CRL4WDR70	13
Variation in G-quadruplex sequence and topology differentially impacts human DNA polymerase fidelity	13
Recent advances in γH2AX biomarker-based genotoxicity assays: A marker of DNA damage and repair	13
NBS1 binds directly to TOPBP1 via disparate interactions between the NBS1 BRCT1 domain and the TOPBP1 BRCT1 and BRCT2 domains	13
Chromosomal single-strand break repair and neurological disease: Implications on transcription and emerging genomic tools	13
Editorial Board	13
Impairment of the non-catalytic subunit Dpb2 of DNA Pol ɛ results in increased involvement of Pol δ on the leading strand	13
TOPBP1 regulates resistance of gastric cancer to oxaliplatin by promoting transcription of PARP1	12
miR-185–5p rewires cisplatin resistance by restoring miR-203a-3p expression via downregulation of SOX9	12
Altered pathways in Cockayne syndrome: Involvement of MAPK, PI3K-Akt, extracellular matrix, inflammation, and neuronal signaling	12
DNA polymerase delta Exo domain stabilizes mononucleotide microsatellites in human cells	11
Cutting Edge Perspectives in genome maintenance X	11
Reversible association of ubiquitin with PCNA is important for template switching in S. cerevisiae	11
Yearly perspective from the Co-Editors in Chief	11
Biochemical characterization and mutational analysis of a mismatch glycosylase from the hyperthermophilic euryarchaeon Thermococcus barophilus Ch5	11
BRCA1 and BRCA2 in DNA damage and replication stress response: Insights into their functions, mechanisms, and implications for cancer treatment	11
Corrigendum to “Role of NEIL1 in genome maintenance” [DNA Repair 148 (2025) 103820]	11
Somatic mutation patterns at Ig and Non-Ig Loci	11
miR-197-5p increases Doxorubicin-mediated anticancer cytotoxicity of HT1080 fibrosarcoma cells by decreasing drug efflux	11
Frailty, sex, and poverty are associated with DNA damage and repair in frail, middle-aged urban adults	11

Inhibition of human DNA alkylation damage repair enzyme ALKBH2 by HIV protease inhibitor ritonavir	11
Insight into meiotic DNA end resection: Mechanisms and regulation	10
Weaponizing CRISPR/Cas9 for selective elimination of cells with an aberrant genome	10
C-terminal residues of DNA polymerase β and E3 ligase required for ubiquitin-linked proteolysis of oxidative DNA-protein crosslinks	10
Oncometabolite 2-hydroxyglutarate suppresses basal protein levels of DNA polymerase beta that enhances alkylating agent and PARG inhibition induced cytotoxicity	10
Increased contribution of DNA polymerase delta to the leading strand replication in yeast with an impaired CMG helicase complex	10
Small-molecule activator of SMUG1 enhances repair of pyrimidine lesions in DNA	10
The flap endonuclease-1 mediated maturation of Okazaki fragments is critical for the cellular tolerance to remdesivir	10
MicroRNAs and the DNA damage response: How is cell fate determined?	10
RNF4 prevents genomic instability caused by chronic DNA under-replication	10
A moving target for drug discovery: Structure activity relationship and many genome (de)stabilizing functions of the RAD52 protein	9
Impact of DNA sequences on DNA ‘opening’ by the Rad4/XPC nucleotide excision repair complex	9
Contents of previous 3 special issues in this series of perspectives	9
TFIIH central activity in nucleotide excision repair to prevent disease	9
Editorial Board	9
Genetic polymorphisms in DNA repair genes and hepatocellular carcinoma risk	9
Presenilin-1, mutated in familial Alzheimer’s disease, maintains genome stability via a γ-secretase dependent way	9
Editorial Board	9
Mechanisms and regulation of replication fork reversal	8
KBM-mediated interactions with KU80 promote cellular resistance to DNA replication stress in CHO cells	8
Mlh1 interacts with both Msh2 and Msh6 for recruitment during mismatch repair	8
Positive and negative regulators of RAD51/DMC1 in homologous recombination and DNA replication	8
Remdesivir triphosphate is a valid substrate to initiate synthesis of DNA primers by human PrimPol	8
Obituary	8
Incorporation of 5’,8-cyclo-2’deoxyadenosines by DNA repair polymerases via base excision repair	8
Phosphorylation-dependent assembly of DNA damage response systems and the central roles of TOPBP1	8
Therapeutic targeting of mismatch repair proteins in triplet repeat expansion diseases	8
Processes shaping cancer genomes – From mitotic defects to chromosomal rearrangements	8
Probing the structure and function of polymerase θ helicase-like domain	8
The mRNA tether model for activation-induced deaminase and its relevance for Ig somatic hypermutation and class switch recombination	7
USP1 in regulation of DNA repair pathways	7
PARPs and ADP-ribosyl hydrolases in cancer therapy: From drug targets to biomarkers	7
Editorial Board	7
Corrigendum to “Quantitative assessment of HR and NHEJ activities via CRISPR/Cas9-induced oligodeoxynucleotide-mediated DSB repair” [DNA Repair 70 (2018) 67–71]	7
DONSON: Slding in 2 the limelight	7
Mouse Embryonic Fibroblasts Isolated From Nthl1 D227Y Knockin Mice Exhibit Defective DNA Repair and Increased Genome Instability	7
Regulation of DNA damage-induced HLA class I presentation	7
Cutting edge perspectives in genome maintenance XI	7
The replication stress response: Mechanisms and functions	7
Significance and limitations of the use of next-generation sequencing technologies for detecting mutational signatures	7
Screening of glycosylase activity on oxidative derivatives of methylcytosine: Pedobacter heparinus SMUG2 as a formylcytosine- and carboxylcytosine-DNA glycosylase	7
Compartmentalization of the DNA damage response: Mechanisms and functions	7
Determination of DNA lesion bypass using a ChIP-based assay	7
SMC-5/6 complex subunit NSE-1 plays a crucial role in meiosis and DNA repair in Caenorhabditis elegans	7
Emerging connections: Poly(ADP-ribose), FET proteins and RNA in the regulation of DNA damage condensates	7
Low and high doses of ionizing radiation evoke discrete global (phospho)proteome responses	7
Biochemical characterization and mutational studies of endonuclease Q from the hyperthermophilic euryarchaeon Thermococcus gammatolerans	7
Variants in the first methionine of RAD51C are homologous recombination proficient due to an alternative start site	7
DNA damage repair (DDR) related prognostic risk model in multiple myeloma based on single-cell and bulk sequencing	6
Errol Friedberg: A life in writing	6
The role of histone H3K36me3 writers, readers and erasers in maintaining genome stability	6
DNA Repair Capacity for Personalizing Risk and Treatment Response − Assay Development and Optimization in Human Peripheral Blood Mononuclear Cells (PBMCs)	6
Structure, function and evolution of the HerA subfamily proteins	6
Temporal and spatial dynamics of DNA double-strand break repair centers	6
Genome integrity and inflammation in the nervous system	6
Real-time single-molecule visualization using DNA curtains reveals the molecular mechanisms underlying DNA repair pathways	6
Reversal of histone H2B mono-ubiquitination is required for replication stress recovery	6
The biochemistry of the carcinogenic alcohol metabolite acetaldehyde	6
Editorial Board	6
DNA lesions that block transcription induce the death of Trypanosoma cruzi via ATR activation, which is dependent on the presence of R-loops	6
Why the ROS matters: One-electron oxidants focus DNA damage and repair on G-quadruplexes for gene regulation	6
Phylogenetic distribution, structural analysis and interaction of nucleotide excision repair proteins in cyanobacteria	6
Single-molecule studies of helicases and translocases in prokaryotic genome-maintenance pathways	6
Editorial Board	6
Transcription coupled base excision repair in mammalian cells: So little is known and so much to uncover	6
XRCC3 loss leads to midgestational embryonic lethality in mice	6
From rest to repair: Safeguarding genomic integrity in quiescent cells	6
Discovery of KPT-6566 as STAG1/2 Inhibitor sensitizing PARP and NHEJ Inhibitors to suppress tumor cells growth in vitro	6
Pold4 subunit of replicative polymerase δ promotes fork slowing at broken templates	6
S-palmitoylation: An oily modification guardinggenome stability	5
Live cell single-molecule imaging to study DNA repair in human cells	5
Replication initiation sites and zones in the mammalian genome: Where are they located and how are they defined?	5
Deletions initiated by the vaccinia virus TopIB protein in yeast	5
FBH1 and the replication stress response: Implications for genome stability and cancer development	5
Determinants governing BRC function evaluated by mutational analysis of Brh2 in Ustilago maydis	5
Editorial Board	5
Histone and Chromatin Dynamics Facilitating DNA repair	5
The fast-growing business of Serine ADP-ribosylation	5
Targeting Wee1 kinase as a therapeutic approach in Hematological Malignancies	5
LncRNA LINC01664 promotes cancer resistance through facilitating homologous recombination-mediated DNA repair	5

The Sm core components of small nuclear ribonucleoproteins promote homologous recombination repair	5
APE1 is a master regulator of the ATR-/ATM-mediated DNA damage response	5
Interaction of mitoxantrone with abasic sites - DNA strand cleavage and inhibition of apurinic/apyrimidinic endonuclease 1, APE1	5
To divide or not to divide? NAC8 (SOG1) as a key regulator of DNA damage response in barley (Hordeum vulgare L.)	5
Repair of genomic interstrand crosslinks	5
Transcription-coupled DNA double-strand break repair	5
Editorial Board	5
Structure and mechanism in non-homologous end joining	5
The roles of non-productive complexes of DNA repair proteins with DNA lesions	5
Multiple functions of PARP1 in the repair of DNA double strand breaks	5
Holding it together: DNA end synapsis during non-homologous end joining	5
Editorial Board	5
Functions of PMS2 and MLH1 important for regulation of divergent repeat-mediated deletions	4
UVSSA facilitates transcription-coupled repair of DNA interstrand crosslinks	4
Modulation of OGG1 enzymatic activity by the cellular machinery – have all the boxes been ticked?	4
The Ataxia-telangiectasia mutated (ATM) is the most important gene for repairing the DNA in Myelodysplastic Neoplasm	4
The nucleotide excision repair proteins through the lens of molecular dynamics simulations	4
Targeting DNA damage sensors for cancer therapy	4
The C-terminal tail of Rad17, iVERGE, binds the 9‒1‒1 complex independently of AAA+ ATPase domains to provide another clamp–loader interface	4
Monitoring DNA polymerase β mitochondrial localization and dynamics	4
Kinome-wide screening uncovers a role for Bromodomain Protein 3 in DNA double-stranded break repair	4
Mechanism for R-loop formation remote from the transcription start site: Topological issues and possible facilitation by dissociation of RNA polymerase	4
A-T neurodegeneration and DNA damage-induced transcriptional stress	4
Cockayne syndrome group B protein uses its DNA translocase activity to promote mitotic DNA synthesis	4
DNA repair pathways in the mitochondria	4
C. elegans ribosomal protein S3 protects against H2O2-induced DNA damage and suppresses spontaneous mutations in yeast	4
Live cell transcription-coupled nucleotide excision repair dynamics revisited	4
Phosphoregulation of the checkpoint kinase Mec1ATR	4
Joining of DNA breaks- interplay between DNA ligases and poly (ADP-ribose) polymerases	4
Toxic R-loops: Cause or consequence of replication stress?	4
The analysis of protein recruitment to laser microirradiation-induced DNA damage in live cells: Best practices for data analysis	4
DNA polymerase δ: A single Pol31 polymorphism suppresses the strain background-specific lethality of Pol32 inactivation in Saccharomyces cerevisiae	4
BCLAF1, a functional partner of BACH1, participates in DNA damage response	4
Global screening of base excision repair in nucleosome core particles	4
Bulk synthesis and beyond: The roles of eukaryotic replicative DNA polymerases	4
DNA damage-induced sumoylation of Sp1 induces its interaction with RNF4 and degradation in S phase to remove 53BP1 from DSBs and permit HR	4
53BP1-the ‘Pandora’s box’ of genome integrity	3
Contributions of DNA double strand break repair pathways to DNA crosslink repair	3
Checkpoint activation and recovery: regulation of the 9–1–1 axis by the PP2A phosphatase	3
UBAP2/UBAP2L regulate UV-induced ubiquitylation of RNA polymerase II and are the human orthologues of yeast Def1	3
Unveiling cGAS mechanisms: Insights into DNA damage and immune sensing in cancer	3
Genomic stress and impaired DNA repair in Alzheimer disease	3
Temporal recruitment of base excision DNA repair factors in living cells in response to different micro-irradiation DNA damage protocols	3
Microglial inflammation in genome instability: A neurodegenerative perspective	3
The DNA damage induced immune response: Implications for cancer therapy	3
Histone variants: The unsung guardians of the genome	3
Multifunctional properties of Nej1XLF C-terminus promote end-joining and impact DNA double-strand break repair pathway choice	3
Mediator complex in transcription regulation and DNA repair: Relevance for human diseases	3
Evolution of the triplet BRCT domain	3
Spontaneous and salt stress-induced molecular instability in the progeny of MSH7 deficient Arabidopsis thaliana plants	3
Editorial	3
Cancer testis antigens and genomic instability: More than immunology	3
DNA topoisomerase IIß inhibition blocks DNA end resection and synergizes with PARPi in BRCA1-deficient models	3
SMUG1 regulates fat homeostasis leading to a fatty liver phenotype in mice	3
The C-terminal domain of Arabidopsis ROS1 DNA demethylase interacts with histone H3 and is required for DNA binding and catalytic activity	3
Biochemical analysis of H2O2-induced mutation spectra revealed that multiple damages were involved in the mutational process	3
Cutting-edge perspectives in genomic maintenance VIII	3
Compared to other NHEJ factors, DNA-PK protein and RNA levels are markedly increased in all higher primates, but not in prosimians or other mammals	3
Editorial Board	3
O-GlcNAc transferase is important for homology-directed repair	3
Lawrence H. Thompson: A life of bikes, birds, and DNA repair (1941–2024)	3
‘From R-lupus to cancer’: Reviewing the role of R-loops in innate immune responses	3
Structure, function and evolution of the Helix-hairpin-Helix DNA glycosylase superfamily: Piecing together the evolutionary puzzle of DNA base damage repair mechanisms	3
Spatio-temporal dynamics of the DNA glycosylase OGG1 in finding and processing 8-oxoguanine	3
Single-molecule toxicogenomics: Optical genome mapping of DNA-damage in nanochannel arrays	3
FAM21 interacts with Ku to promote the localization of WASH to DNA double strand break sites	3
Overexpression of the WWE domain of RNF146 modulates poly-(ADP)-ribose dynamics at sites of DNA damage	3
Partial deletions of the autoregulatory C-terminal domain of Artemis and their effect on its nuclease activity	3
Large-scale generation and phenotypic characterization of zebrafish CRISPR mutants of DNA repair genes	3
Histone lysine modifying enzymes and their critical roles in DNA double-strand break repair	3
Non-canonical function of nuclear PTEN and its implication on tumorigenesis	3
DNA damage response inhibitors in cancer therapy: Mechanisms, clinical development, and combination strategies	2
How RNA impacts DNA repair	2
Super-resolution GSDIM microscopy unveils distinct nanoscale characteristics of DNA repair foci under diverse genotoxic stress	2
The effect of methylation and hydroxymethylation of cytosine on activity and fidelity of Pol λ and Pol β	2
Polymorphic variant Asp239Tyr of human DNA glycosylase NTHL1 is inactive for removal of a variety of oxidatively-induced DNA base lesions from genomic DNA	2
Divergent structures of Mammalian and gammaherpesvirus uracil DNA glycosylases confer distinct DNA binding and substrate activity	2
The dual role of DNA repair protein MGMT in cancer prevention and treatment	2
Editorial Board	2
The model moss Physcomitrium patens relies heavily on homologous recombination to repair DNA double-strand breaks	2
The HPF1-dependent histone PARylation catalyzed by PARP2 is specifically stimulated by an incised AP site-containing BER DNA intermediate	2
Differential ETS1 binding to T:G mismatches within a CpG dinucleotide contributes to C-to-T somatic mutation rate of the IDH2 hotspot at codon Arg140	2
A redox-sensitive iron-sulfur cluster in murine FAM72A controls its ability to degrade the nuclear form of uracil-DNA glycosylase	2
Imaging the cellular response to an antigen tagged interstrand crosslinking agent	2
Rrp1, Rrp2 and Uls1 – Yeast SWI2/SNF2 DNA dependent translocases in genome stability maintenance	2
Initiation of base excision repair is modulated by nucleosome occupancy modifying sequences	2
Genome organization and stability in mammalian pre-implantation development	2
The DHX9 helicase interacts with human DNA polymerase δ4 and stimulates its activity in D-loop extension synthesis	2
The interactions between DNA methylation machinery and long non-coding RNAs in tumor progression and drug resistance	2
Methylation and hydroxymethylation of cytosine alter activity and fidelity of translesion DNA polymerases	2
UBE2C promotes cell cycle progression and suppresses DNA damage-induced apoptosis in triple-negative breast cancer	2
Role of the nucleotide excision repair pathway proteins (UvrB and UvrD2) in recycling UdgB, a base excision repair enzyme in Mycobacterium smegmatis	2
Editorial Board	2
Role of HSP40 proteins in genome maintenance, insulin signaling and cancer therapy	2
The HNH endonuclease domain of the giant virus MutS7 specifically binds to branched DNA structures with single-stranded regions	2