DNA Repair

Article	Citations
Active genome integrity	64
Contents of previous 3 special issues in this series of perspectives	56
Regulatory apoptotic fragment of PARP1 complements catalytic fragment for PAR and DNA-dependent activity but inhibits DNA-induced catalytic stimulation of PARP2	53
DNA polymerase λ Loop1 variant yields unexpected gain-of-function capabilities in nonhomologous end-joining	45
Building an integrated view of R-loops, transcription, and chromatin	41
Spatial mapping of the DNA adducts in cancer	40
Suppressors of Blm-deficiency identify three novel proteins that facilitate DNA repair in Ustilago maydis	37
Functional defects of cancer-associated MDC1 mutations in DNA damage repair	35
Activation of Escherichia coli RecA* in recA730 lexA+ and recA730 lexA(Def) strain backgrounds	28
Editors’ note Penny Jeggo and Bennett Van Houten	27
From cooperation to conflicts – A complicated relationship between transcription and replication	26
Single-molecule imaging of genome maintenance proteins encountering specific DNA sequences and structures	26
Single-molecule approaches for DNA damage detection and repair: A focus on Repair Assisted Damage Detection (RADD)	26
The role of human PrimPol active site residue Gln48 in catalysis and complex formation with DNA	24
Harnessing R-loop dynamics: Challenging cancer therapy resistance	23
The burden of overweight: Higher body mass index, but not vital exhaustion, is associated with higher DNA damage and lower DNA repair capacity	23
A novel Family V uracil DNA glycosylase from Sulfolobus islandicus REY15A	22
Irc20 modulates LOH frequency and distribution in S. cerevisiae	22
Stressed? Break-induced replication comes to the rescue!	22
Editorial Board	21
Editorial Board	21
Chromatin meets the cytoskeleton: the importance of nuclear actin dynamics and associated motors for genome stability	20
PARP inhibitors in ovarian cancer: Mechanisms of resistance and implications to therapy	19
Comparing Mfd- and UvrD-dependent models of transcription coupled DNA repair in live Escherichia coli using single-molecule tracking	18
PARP1-PROTACs providing novel opportunities in precision oncology by targeting DNA damage response	18

What are the DNA lesions underlying formaldehyde toxicity?	18
Corruption of DNA end-joining in mammalian chromosomes by progerin expression	18
DNA damage response and genomic instability disorder: Meeting report of the 20th Ataxia-Telangiectasia Workshop (ATW-2024) in conjunction with the 15th international symposium on DNA damage response &	18
The B cell dilemma: Diversity or fidelity?	18
Targeting base excision repair in precision oncology	17
Editorial Board	17
Positioning loss of PARP1 activity as the central toxic event in BRCA-deficient cancer	17
DNA repair-related heritable photosensitivity syndromes: Mutation landscape in a multiethnic cohort of 17 multigenerational families with high degree of consanguinity	17
The role of SLFN11 in DNA replication stress response and its implications for the Fanconi anemia pathway	16
The differential roles of rad9 alternatively spliced forms in double- strand DNA break repair during Drosophila meiosis	16
The interferon response at the intersection of genome integrity and innate immunity	16
Double-strand break repair and mis-repair in 3D	16
Metazoan nuclear pore complexes in gene regulation and genome stability	15
Protein-protein interactions in the core nucleotide excision repair pathway	15
Editorial Board	15
Phospho-SIM and exon8b of PML protein regulate formation of doxorubicin-induced rDNA-PML compartment	15
DNA synthesis across DNA hairpins by human PrimPol	15
The multifaceted roles of the Ctf4 replisome hub in the maintenance of genome integrity	14
Richard Gatti: From concert pianist to bone marrow transplants and the DNA damage response syndrome, ataxia-telangiectasia	14
Chromosomal single-strand break repair and neurological disease: Implications on transcription and emerging genomic tools	14
Loss of alkyladenine DNA glycosylase alters gene expression in the developing mouse brain and leads to reduced anxiety and improved memory	14
Centromere: A Trojan horse for genome stability	14
NBS1 binds directly to TOPBP1 via disparate interactions between the NBS1 BRCT1 domain and the TOPBP1 BRCT1 and BRCT2 domains	13
Impairment of the non-catalytic subunit Dpb2 of DNA Pol ɛ results in increased involvement of Pol δ on the leading strand	13
Using the safety scissors: DNA resection regulation at DNA double-strand breaks and telomeres	13
Variation in G-quadruplex sequence and topology differentially impacts human DNA polymerase fidelity	13
One-ended and two-ended breaks at nickase-broken replication forks	13
Inhibition of human DNA alkylation damage repair enzyme ALKBH2 by HIV protease inhibitor ritonavir	13
Long-range PCR as a tool for evaluating mitochondrial DNA damage: Principles, benefits, and limitations of the technique	13
Endogenous base damage as a driver of genomic instability in homologous recombination-deficient cancers	13
Cutting Edge Perspectives in genome maintenance X	13
Altered pathways in Cockayne syndrome: Involvement of MAPK, PI3K-Akt, extracellular matrix, inflammation, and neuronal signaling	12
Somatic mutation patterns at Ig and Non-Ig Loci	12
miR-185–5p rewires cisplatin resistance by restoring miR-203a-3p expression via downregulation of SOX9	12
Biochemical characterization and mutational analysis of a mismatch glycosylase from the hyperthermophilic euryarchaeon Thermococcus barophilus Ch5	12
Weaponizing CRISPR/Cas9 for selective elimination of cells with an aberrant genome	11
How DNA secondary structures drive replication fork instability	11
Altered lipid profile in mice lacking the DNA repair protein ERCC1	11
Reversible association of ubiquitin with PCNA is important for template switching in S. cerevisiae	11
Presenilin-1, mutated in familial Alzheimer’s disease, maintains genome stability via a γ-secretase dependent way	11
Corrigendum to “Role of NEIL1 in genome maintenance” [DNA Repair 148 (2025) 103820]	11
Frailty, sex, and poverty are associated with DNA damage and repair in frail, middle-aged urban adults	11
BRCA1 and BRCA2 in DNA damage and replication stress response: Insights into their functions, mechanisms, and implications for cancer treatment	11
Insight into meiotic DNA end resection: Mechanisms and regulation	10
A moving target for drug discovery: Structure activity relationship and many genome (de)stabilizing functions of the RAD52 protein	10
C-terminal residues of DNA polymerase β and E3 ligase required for ubiquitin-linked proteolysis of oxidative DNA-protein crosslinks	10
Editorial Board	10
DNA Repair Special Issue: Genome maintenance pathways in cancer - etiology, biomarkers and targets	10
TFIIH central activity in nucleotide excision repair to prevent disease	10
Contents of previous 3 special issues in this series of perspectives	10

Oncometabolite 2-hydroxyglutarate suppresses basal protein levels of DNA polymerase beta that enhances alkylating agent and PARG inhibition induced cytotoxicity	10
RNF4 prevents genomic instability caused by chronic DNA under-replication	10
The flap endonuclease-1 mediated maturation of Okazaki fragments is critical for the cellular tolerance to remdesivir	10
Small-molecule activator of SMUG1 enhances repair of pyrimidine lesions in DNA	9
Regulation of DNA damage-induced HLA class I presentation	9
A special issue: DNA damage response in disease and therapy	9
Therapeutic targeting of mismatch repair proteins in triplet repeat expansion diseases	9
Mechanisms and regulation of replication fork reversal	9
Remdesivir triphosphate is a valid substrate to initiate synthesis of DNA primers by human PrimPol	9
KBM-mediated interactions with KU80 promote cellular resistance to DNA replication stress in CHO cells	9
USP1 in regulation of DNA repair pathways	9
Probing the structure and function of polymerase θ helicase-like domain	9
Obituary	9
Mlh1 interacts with both Msh2 and Msh6 for recruitment during mismatch repair	9
Positive and negative regulators of RAD51/DMC1 in homologous recombination and DNA replication	9
Emerging connections: Poly(ADP-ribose), FET proteins and RNA in the regulation of DNA damage condensates	8
Cutting edge perspectives in genome maintenance XI	8
The replication stress response: Mechanisms and functions	8
Pold4 subunit of replicative polymerase δ promotes fork slowing at broken templates	8
Biochemical characterization and mutational studies of endonuclease Q from the hyperthermophilic euryarchaeon Thermococcus gammatolerans	8
Compartmentalization of the DNA damage response: Mechanisms and functions	8
PARPs and ADP-ribosyl hydrolases in cancer therapy: From drug targets to biomarkers	8
Phylogenetic distribution, structural analysis and interaction of nucleotide excision repair proteins in cyanobacteria	8
Variants in the first methionine of RAD51C are homologous recombination proficient due to an alternative start site	8
Genome integrity and inflammation in the nervous system	8
DNA lesions that block transcription induce the death of Trypanosoma cruzi via ATR activation, which is dependent on the presence of R-loops	8
Real-time single-molecule visualization using DNA curtains reveals the molecular mechanisms underlying DNA repair pathways	8
SMC-5/6 complex subunit NSE-1 plays a crucial role in meiosis and DNA repair in Caenorhabditis elegans	8
Discovery of KPT-6566 as STAG1/2 Inhibitor sensitizing PARP and NHEJ Inhibitors to suppress tumor cells growth in vitro	8
DONSON: Slding in 2 the limelight	8
Screening of glycosylase activity on oxidative derivatives of methylcytosine: Pedobacter heparinus SMUG2 as a formylcytosine- and carboxylcytosine-DNA glycosylase	8
Why the ROS matters: One-electron oxidants focus DNA damage and repair on G-quadruplexes for gene regulation	8
Tribute to life and science of Grigory (Gosha) Dianov	8
Editorial Board	7
Structure, function and evolution of the HerA subfamily proteins	7
The role of histone H3K36me3 writers, readers and erasers in maintaining genome stability	7
Reversal of histone H2B mono-ubiquitination is required for replication stress recovery	7
Repair of genomic interstrand crosslinks	7
DNA damage repair (DDR) related prognostic risk model in multiple myeloma based on single-cell and bulk sequencing	7
The biochemistry of the carcinogenic alcohol metabolite acetaldehyde	7
Editorial Board	7
LncRNA LINC01664 promotes cancer resistance through facilitating homologous recombination-mediated DNA repair	7
Determinants governing BRC function evaluated by mutational analysis of Brh2 in Ustilago maydis	7
The roles of non-productive complexes of DNA repair proteins with DNA lesions	7
APE1 is a master regulator of the ATR-/ATM-mediated DNA damage response	7
Live cell single-molecule imaging to study DNA repair in human cells	7
Replication initiation sites and zones in the mammalian genome: Where are they located and how are they defined?	7
From rest to repair: Safeguarding genomic integrity in quiescent cells	7
Errol Friedberg: A life in writing	7
Deletions initiated by the vaccinia virus TopIB protein in yeast	7
Structure and mechanism in non-homologous end joining	7
Interaction of mitoxantrone with abasic sites - DNA strand cleavage and inhibition of apurinic/apyrimidinic endonuclease 1, APE1	7
Holding it together: DNA end synapsis during non-homologous end joining	7
Temporal and spatial dynamics of DNA double-strand break repair centers	7
S-palmitoylation: An oily modification guardinggenome stability	6
Editorial Board	6
BCLAF1, a functional partner of BACH1, participates in DNA damage response	6
A-T neurodegeneration and DNA damage-induced transcriptional stress	6
The analysis of protein recruitment to laser microirradiation-induced DNA damage in live cells: Best practices for data analysis	6
C. elegans ribosomal protein S3 protects against H2O2-induced DNA damage and suppresses spontaneous mutations in yeast	6
Multiple functions of PARP1 in the repair of DNA double strand breaks	6
The nucleotide excision repair proteins through the lens of molecular dynamics simulations	6
To divide or not to divide? NAC8 (SOG1) as a key regulator of DNA damage response in barley (Hordeum vulgare L.)	6
Modulation of OGG1 enzymatic activity by the cellular machinery – have all the boxes been ticked?	6
The fast-growing business of Serine ADP-ribosylation	6
FBH1 and the replication stress response: Implications for genome stability and cancer development	6
DNA polymerase δ: A single Pol31 polymorphism suppresses the strain background-specific lethality of Pol32 inactivation in Saccharomyces cerevisiae	6
Cockayne syndrome group B protein uses its DNA translocase activity to promote mitotic DNA synthesis	6
Bulk synthesis and beyond: The roles of eukaryotic replicative DNA polymerases	6
Editorial Board	5
Live cell transcription-coupled nucleotide excision repair dynamics revisited	5
O-GlcNAc transferase is important for homology-directed repair	5
Biochemical analysis of H2O2-induced mutation spectra revealed that multiple damages were involved in the mutational process	5
Compared to other NHEJ factors, DNA-PK protein and RNA levels are markedly increased in all higher primates, but not in prosimians or other mammals	5
The C-terminal tail of Rad17, iVERGE, binds the 9‒1‒1 complex independently of AAA+ ATPase domains to provide another clamp–loader interface	5
DNA repair pathways in the mitochondria	5
Multifunctional properties of Nej1XLF C-terminus promote end-joining and impact DNA double-strand break repair pathway choice	5
Global screening of base excision repair in nucleosome core particles	5
SMUG1 regulates fat homeostasis leading to a fatty liver phenotype in mice	5
Genomic stress and impaired DNA repair in Alzheimer disease	5

Microglial inflammation in genome instability: A neurodegenerative perspective	5
Targeting DNA damage sensors for cancer therapy	5
Phosphoregulation of the checkpoint kinase Mec1ATR	5
Monitoring DNA polymerase β mitochondrial localization and dynamics	5
Joining of DNA breaks- interplay between DNA ligases and poly (ADP-ribose) polymerases	5
The Ataxia-telangiectasia mutated (ATM) is the most important gene for repairing the DNA in Myelodysplastic Neoplasm	5
‘From R-lupus to cancer’: Reviewing the role of R-loops in innate immune responses	5
53BP1-the ‘Pandora’s box’ of genome integrity	5
DNA G-quadruplexes: Structural and functional insights	5
UVSSA facilitates transcription-coupled repair of DNA interstrand crosslinks	5
Kinome-wide screening uncovers a role for Bromodomain Protein 3 in DNA double-stranded break repair	5
Functions of PMS2 and MLH1 important for regulation of divergent repeat-mediated deletions	5
Editorial Board	4
Temporal recruitment of base excision DNA repair factors in living cells in response to different micro-irradiation DNA damage protocols	4
How to write an ending: Telomere replication as a multistep process	4
UBAP2/UBAP2L regulate UV-induced ubiquitylation of RNA polymerase II and are the human orthologues of yeast Def1	4
Recent advances in understanding the molecular mechanisms of SLX4 recruitment in the replication stress response	4
Evolution of the triplet BRCT domain	4
Clinical evidence for a role of E2F1-induced replication stress in modulating tumor mutational burden and immune microenvironment	4
Polymerase theta: Genome protection through regulated deployment	4
The DNA damage induced immune response: Implications for cancer therapy	4
Editorial	4
Transcription reprogramming and endogenous DNA damage	4
Editorial Board	4
DNA repair deficiencies and neurodegeneration	4
DNA topoisomerase IIß inhibition blocks DNA end resection and synergizes with PARPi in BRCA1-deficient models	4
Saccharomyces cerevisiae apurinic/apyrimidinic endonuclease 1 repairs abasic site-mediated DNA-peptide/protein cross-links	4
Overexpression of the WWE domain of RNF146 modulates poly-(ADP)-ribose dynamics at sites of DNA damage	4
Spatio-temporal dynamics of the DNA glycosylase OGG1 in finding and processing 8-oxoguanine	4
Mediator complex in transcription regulation and DNA repair: Relevance for human diseases	4
Partial deletions of the autoregulatory C-terminal domain of Artemis and their effect on its nuclease activity	4
A tale of two mechanisms: Clarification of the pathway for MBD4 catalyzed glycosidic bond cleavage using MD and QM/MM calculations	4
Checkpoint activation and recovery: regulation of the 9–1–1 axis by the PP2A phosphatase	4
Rrp1, Rrp2 and Uls1 – Yeast SWI2/SNF2 DNA dependent translocases in genome stability maintenance	4
A bibliometric analysis of research on R-loop: Landscapes, highlights and trending topics	4
Spontaneous and salt stress-induced molecular instability in the progeny of MSH7 deficient Arabidopsis thaliana plants	4
Unveiling cGAS mechanisms: Insights into DNA damage and immune sensing in cancer	4
Contributions of DNA double strand break repair pathways to DNA crosslink repair	4
Single-molecule toxicogenomics: Optical genome mapping of DNA-damage in nanochannel arrays	4
FBH1 deficiency sensitizes cells to WEE1 inhibition by promoting mitotic catastrophe	4
Lawrence H. Thompson: A life of bikes, birds, and DNA repair (1941–2024)	4
FAM21 interacts with Ku to promote the localization of WASH to DNA double strand break sites	4
The C-terminal domain of Arabidopsis ROS1 DNA demethylase interacts with histone H3 and is required for DNA binding and catalytic activity	4
Synergistic effects on mutagenicity of tandem lesions containing 8-oxo-7,8-dihydro-2′-deoxyguanosine or Fapy•dG flanked by a 3′ 5-formyl-2′-deoxyuridine in human cells	4
Ku80 is indispensable for repairing DNA double-strand breaks at highly methylated sites in human HCT116 cells	3
NEIL3 promotes cell proliferation of ccRCC via the cyclin D1-Rb-E2F1 feedback loop regulation	3
Editorial Board	3
DNA damage response inhibitors in cancer therapy: Mechanisms, clinical development, and combination strategies	3
The interactions between DNA methylation machinery and long non-coding RNAs in tumor progression and drug resistance	3
Imaging the cellular response to an antigen tagged interstrand crosslinking agent	3
Development and characterization of a novel NEIL1 nanobody	3
Multi-scale cellular imaging of DNA double strand break repair	3
The role of DNA repair deficiency in lipid accumulation: A proof-of-concept study	3
Genome organization and stability in mammalian pre-implantation development	3
Efficient activity of uracil DNA glycosylase (UNG2) in proliferating cells requires binding to proliferating cell nuclear antigen (PCNA) and replication protein A (RPA)	3
Intersection of the fragile X-related disorders and the DNA damage response	3
The HNH endonuclease domain of the giant virus MutS7 specifically binds to branched DNA structures with single-stranded regions	3
The effect of methylation and hydroxymethylation of cytosine on activity and fidelity of Pol λ and Pol β	3
Methylation and hydroxymethylation of cytosine alter activity and fidelity of translesion DNA polymerases	3
The DHX9 helicase interacts with human DNA polymerase δ4 and stimulates its activity in D-loop extension synthesis	3
The HPF1-dependent histone PARylation catalyzed by PARP2 is specifically stimulated by an incised AP site-containing BER DNA intermediate	3
Polymorphic variant Asp239Tyr of human DNA glycosylase NTHL1 is inactive for removal of a variety of oxidatively-induced DNA base lesions from genomic DNA	3
Editors’ note on “p21CDKN1A participates in base excision repair by regulating the activity of poly(ADP-ribose) polymerase-1”	3
Helicase activities of Rad5 and Rrm3 genetically interact in the prevention of recombinogenic DNA lesions in Saccharomyces cerevisiae	3
Mechanisms of tandem duplication in the cancer genome	3
Replication stress drives chromosomal instability in fibroblasts of childhood cancer survivors with second primary neoplasms	3
The multifaceted functions of homologous recombination in dealing with replication-associated DNA damages	3
How RNA impacts DNA repair	3
The model moss Physcomitrium patens relies heavily on homologous recombination to repair DNA double-strand breaks	3
Mechanistic insights into RAD51-mediated nucleosome binding and remodeling in homologous recombination	3
Super-resolution GSDIM microscopy unveils distinct nanoscale characteristics of DNA repair foci under diverse genotoxic stress	3
Divergent structures of Mammalian and gammaherpesvirus uracil DNA glycosylases confer distinct DNA binding and substrate activity	3
Role of HSP40 proteins in genome maintenance, insulin signaling and cancer therapy	3
UBE2C promotes cell cycle progression and suppresses DNA damage-induced apoptosis in triple-negative breast cancer	3
Exploring factors influencing choice of DNA double-strand break repair pathways	3
A redox-sensitive iron-sulfur cluster in murine FAM72A controls its ability to degrade the nuclear form of uracil-DNA glycosylase	3