DNA Repair

Article	Citations
Spatial mapping of the DNA adducts in cancer	81
Suppressors of Blm-deficiency identify three novel proteins that facilitate DNA repair in Ustilago maydis	80
Functional defects of cancer-associated MDC1 mutations in DNA damage repair	78
Regulatory apoptotic fragment of PARP1 complements catalytic fragment for PAR and DNA-dependent activity but inhibits DNA-induced catalytic stimulation of PARP2	72
Active genome integrity	59
DNA polymerase λ Loop1 variant yields unexpected gain-of-function capabilities in nonhomologous end-joining	49
Loss of an ABC transporter in Arabidopsis thaliana confers hypersensitivity to the anti-cancer drug bleomycin	45
Timely upstream events regulating nucleotide excision repair by ubiquitin-proteasome system: ubiquitin guides the way	44
Building an integrated view of R-loops, transcription, and chromatin	43
Single-molecule imaging of genome maintenance proteins encountering specific DNA sequences and structures	39
Acetylation of H3K56 orchestrates UV-responsive chromatin events that generate DNA accessibility during Nucleotide Excision Repair	36
Editorial Board	35
Stressed? Break-induced replication comes to the rescue!	34
Single-molecule approaches for DNA damage detection and repair: A focus on Repair Assisted Damage Detection (RADD)	34
The burden of overweight: Higher body mass index, but not vital exhaustion, is associated with higher DNA damage and lower DNA repair capacity	33
Corruption of DNA end-joining in mammalian chromosomes by progerin expression	32
A novel Family V uracil DNA glycosylase from Sulfolobus islandicus REY15A	32
WITHDRAWN: Melatonin increases doxorubicin-induced apoptosis via oxidative DNA damage in oral squamous cell carcinoma	30
Irc20 modulates LOH frequency and distribution in S. cerevisiae	30
Editorial Board	29
Editorial Board	28
Effect of mismatch repair on the mutational footprint of the bacterial SOS mutator activity	28
Editorial Board	28
Comparing Mfd- and UvrD-dependent models of transcription coupled DNA repair in live Escherichia coli using single-molecule tracking	28
Targeting base excision repair in precision oncology	26

PARP inhibitors in ovarian cancer: Mechanisms of resistance and implications to therapy	26
Positioning loss of PARP1 activity as the central toxic event in BRCA-deficient cancer	25
Chromatin meets the cytoskeleton: the importance of nuclear actin dynamics and associated motors for genome stability	24
Replication initiation: Implications in genome integrity	24
rumAB genes from SXT/R391 ICEs confer UV-induced mutability to Proteus mirabilis hosts and improve conjugation after UV irradiation	24
DNA synthesis across DNA hairpins by human PrimPol	21
Editorial Board	21
The role of SLFN11 in DNA replication stress response and its implications for the Fanconi anemia pathway	21
What are the DNA lesions underlying formaldehyde toxicity?	21
DNA repair-related heritable photosensitivity syndromes: Mutation landscape in a multiethnic cohort of 17 multigenerational families with high degree of consanguinity	21
PARP1-PROTACs providing novel opportunities in precision oncology by targeting DNA damage response	21
RETRACTED: Thymoquinone sensitizes human hepatocarcinoma cells to TRAIL-induced apoptosis via oxidative DNA damage	20
Double-strand break repair and mis-repair in 3D	20
Metazoan nuclear pore complexes in gene regulation and genome stability	19
Strand discrimination in DNA mismatch repair	19
The differential roles of rad9 alternatively spliced forms in double- strand DNA break repair during Drosophila meiosis	19
The interferon response at the intersection of genome integrity and innate immunity	19
NBS1 binds directly to TOPBP1 via disparate interactions between the NBS1 BRCT1 domain and the TOPBP1 BRCT1 and BRCT2 domains	18
The dark side of homology-directed repair	18
ADP-ribosylation of DNA and RNA	18
Phospho-SIM and exon8b of PML protein regulate formation of doxorubicin-induced rDNA-PML compartment	18
Transcription-coupled nucleotide excision repair: New insights revealed by genomic approaches	18
Protein-protein interactions in the core nucleotide excision repair pathway	18
Mutagenic repair of a ZFN-induced double-strand break in yeast: Effects of cleavage site sequence and spacer size	17
Damage-Net: A program for DNA repair meta-analysis identifies a network of novel repair genes that facilitate cancer evolution	17
Camptothecin compromises transcription recovery and cell survival against cisplatin and ultraviolet irradiation regardless of transcription-coupled nucleotide excision repair	17
Expression of BRCA1, BRCA2, RAD51, and other DSB repair factors is regulated by CRL4WDR70	16
XPA is susceptible to proteolytic cleavage by cathepsin L during lysis of quiescent cells	16
Long-range PCR as a tool for evaluating mitochondrial DNA damage: Principles, benefits, and limitations of the technique	16
Loss of alkyladenine DNA glycosylase alters gene expression in the developing mouse brain and leads to reduced anxiety and improved memory	16
Editorial Board	16
Large dataset of octocoral mitochondrial genomes provides new insights into mt-mutS evolution and function	15
One-ended and two-ended breaks at nickase-broken replication forks	15
Endogenous base damage as a driver of genomic instability in homologous recombination-deficient cancers	15
Variation in G-quadruplex sequence and topology differentially impacts human DNA polymerase fidelity	15
Chromosomal single-strand break repair and neurological disease: Implications on transcription and emerging genomic tools	15
Centromere: A Trojan horse for genome stability	15
Sequence context effects of replication of Fapy•dG in three mutational hot spot sequences of the p53 gene in human cells	15
The multifaceted roles of the Ctf4 replisome hub in the maintenance of genome integrity	15
Recent advances in γH2AX biomarker-based genotoxicity assays: A marker of DNA damage and repair	15
Cutting Edge Perspectives in genome maintenance X	14
Yearly perspective from the Co-Editors in Chief	14
Biochemical characterization and mutational analysis of a mismatch glycosylase from the hyperthermophilic euryarchaeon Thermococcus barophilus Ch5	14
The life and legacy of Sam Wilson (1939–2021)	13
miR-185–5p rewires cisplatin resistance by restoring miR-203a-3p expression via downregulation of SOX9	13
DNA glycosylase deficiency leads to decreased severity of lupus in the Polb-Y265C mouse model	13
miR-197-5p increases Doxorubicin-mediated anticancer cytotoxicity of HT1080 fibrosarcoma cells by decreasing drug efflux	13
Somatic mutation patterns at Ig and Non-Ig Loci	13
Inhibition of human DNA alkylation damage repair enzyme ALKBH2 by HIV protease inhibitor ritonavir	13
Increased contribution of DNA polymerase delta to the leading strand replication in yeast with an impaired CMG helicase complex	13

TOPBP1 regulates resistance of gastric cancer to oxaliplatin by promoting transcription of PARP1	13
DNA polymerase delta Exo domain stabilizes mononucleotide microsatellites in human cells	13
Impairment of the non-catalytic subunit Dpb2 of DNA Pol ɛ results in increased involvement of Pol δ on the leading strand	13
Reversible association of ubiquitin with PCNA is important for template switching in S. cerevisiae	12
PARP1: Structural insights and pharmacological targets for inhibition	12
Weaponizing CRISPR/Cas9 for selective elimination of cells with an aberrant genome	12
Frailty, sex, and poverty are associated with DNA damage and repair in frail, middle-aged urban adults	12
Corrigendum to “Role of NEIL1 in genome maintenance” [DNA Repair 148 (2025) 103820]	12
MicroRNAs and the DNA damage response: How is cell fate determined?	12
BRCA1 and BRCA2 in DNA damage and replication stress response: Insights into their functions, mechanisms, and implications for cancer treatment	12
Editorial Board	11
C-terminal residues of DNA polymerase β and E3 ligase required for ubiquitin-linked proteolysis of oxidative DNA-protein crosslinks	11
Editorial Board	11
The flap endonuclease-1 mediated maturation of Okazaki fragments is critical for the cellular tolerance to remdesivir	11
Contents of previous 3 special issues in this series of perspectives	11
Small-molecule activator of SMUG1 enhances repair of pyrimidine lesions in DNA	11
Presenilin-1, mutated in familial Alzheimer’s disease, maintains genome stability via a γ-secretase dependent way	10
Genetic polymorphisms in DNA repair genes and hepatocellular carcinoma risk	10
Mechanisms and regulation of replication fork reversal	10
A moving target for drug discovery: Structure activity relationship and many genome (de)stabilizing functions of the RAD52 protein	10
Impact of DNA sequences on DNA ‘opening’ by the Rad4/XPC nucleotide excision repair complex	10
RNF4 prevents genomic instability caused by chronic DNA under-replication	10
Oncometabolite 2-hydroxyglutarate suppresses basal protein levels of DNA polymerase beta that enhances alkylating agent and PARG inhibition induced cytotoxicity	10
CometChip enables parallel analysis of multiple DNA repair activities	10
Processes shaping cancer genomes – From mitotic defects to chromosomal rearrangements	9
Determination of DNA lesion bypass using a ChIP-based assay	9
KBM-mediated interactions with KU80 promote cellular resistance to DNA replication stress in CHO cells	9
Incorporation of 5’,8-cyclo-2’deoxyadenosines by DNA repair polymerases via base excision repair	9
Probing the structure and function of polymerase θ helicase-like domain	9
Multi-omic analysis of altered transcriptome and epigenetic signatures in the UV-induced DNA damage response	9
Remdesivir triphosphate is a valid substrate to initiate synthesis of DNA primers by human PrimPol	9
Regulation of DNA damage-induced HLA class I presentation	9
Positive and negative regulators of RAD51/DMC1 in homologous recombination and DNA replication	9
Obituary	9
TFIIH central activity in nucleotide excision repair to prevent disease	9
Therapeutic targeting of mismatch repair proteins in triplet repeat expansion diseases	9
USP1 in regulation of DNA repair pathways	9
Phosphorylation-dependent assembly of DNA damage response systems and the central roles of TOPBP1	9
The mRNA tether model for activation-induced deaminase and its relevance for Ig somatic hypermutation and class switch recombination	8
Corrigendum to “Quantitative assessment of HR and NHEJ activities via CRISPR/Cas9-induced oligodeoxynucleotide-mediated DSB repair” [DNA Repair 70 (2018) 67–71]	8
Mlh1 interacts with both Msh2 and Msh6 for recruitment during mismatch repair	8
Phylogenetic distribution, structural analysis and interaction of nucleotide excision repair proteins in cyanobacteria	8
DNA lesions that block transcription induce the death of Trypanosoma cruzi via ATR activation, which is dependent on the presence of R-loops	8
Editorial Board	8
Screening of glycosylase activity on oxidative derivatives of methylcytosine: Pedobacter heparinus SMUG2 as a formylcytosine- and carboxylcytosine-DNA glycosylase	8
Pold4 subunit of replicative polymerase δ promotes fork slowing at broken templates	8
Low and high doses of ionizing radiation evoke discrete global (phospho)proteome responses	7
Why the ROS matters: One-electron oxidants focus DNA damage and repair on G-quadruplexes for gene regulation	7
Role of the multifunctional transcription factor TFII-I in DNA damage repair	7
Cutting edge perspectives in genome maintenance XI	7
Biochemical characterization and mutational studies of endonuclease Q from the hyperthermophilic euryarchaeon Thermococcus gammatolerans	7
Mouse Embryonic Fibroblasts Isolated From Nthl1 D227Y Knockin Mice Exhibit Defective DNA Repair and Increased Genome Instability	7
SMC-5/6 complex subunit NSE-1 plays a crucial role in meiosis and DNA repair in Caenorhabditis elegans	7
The replication stress response: Mechanisms and functions	7
Genome integrity and inflammation in the nervous system	7
Variants in the first methionine of RAD51C are homologous recombination proficient due to an alternative start site	7
Significance and limitations of the use of next-generation sequencing technologies for detecting mutational signatures	7
Compartmentalization of the DNA damage response: Mechanisms and functions	7
DONSON: Slding in 2 the limelight	7
Discovery of KPT-6566 as STAG1/2 Inhibitor sensitizing PARP and NHEJ Inhibitors to suppress tumor cells growth in vitro	6
Errol Friedberg: A life in writing	6
Real-time single-molecule visualization using DNA curtains reveals the molecular mechanisms underlying DNA repair pathways	6
From rest to repair: Safeguarding genomic integrity in quiescent cells	6
Replication initiation sites and zones in the mammalian genome: Where are they located and how are they defined?	6
Editorial Board	6
Editorial Board	6
Editorial Board	6
Reversal of histone H2B mono-ubiquitination is required for replication stress recovery	6
Targeting Wee1 kinase as a therapeutic approach in Hematological Malignancies	6
Single-molecule studies of helicases and translocases in prokaryotic genome-maintenance pathways	6
Emerging connections: Poly(ADP-ribose), FET proteins and RNA in the regulation of DNA damage condensates	6
Structure, function and evolution of the HerA subfamily proteins	6
XRCC3 loss leads to midgestational embryonic lethality in mice	6
LncRNA LINC01664 promotes cancer resistance through facilitating homologous recombination-mediated DNA repair	6
Transcription coupled base excision repair in mammalian cells: So little is known and so much to uncover	6
APE1 is a master regulator of the ATR-/ATM-mediated DNA damage response	5
The nucleotide excision repair proteins through the lens of molecular dynamics simulations	5
Editorial Board	5
To divide or not to divide? NAC8 (SOG1) as a key regulator of DNA damage response in barley (Hordeum vulgare L.)	5
DNA polymerase δ: A single Pol31 polymorphism suppresses the strain background-specific lethality of Pol32 inactivation in Saccharomyces cerevisiae	5

The roles of non-productive complexes of DNA repair proteins with DNA lesions	5
Structure and mechanism in non-homologous end joining	5
Deletions initiated by the vaccinia virus TopIB protein in yeast	5
The biochemistry of the carcinogenic alcohol metabolite acetaldehyde	5
Live cell single-molecule imaging to study DNA repair in human cells	5
PARP1-mediated PARylation of TonEBP prevents R-loop–associated DNA damage	5
BCLAF1, a functional partner of BACH1, participates in DNA damage response	5
Editorial Board	5
The fast-growing business of Serine ADP-ribosylation	5
Repair of genomic interstrand crosslinks	5
Determinants governing BRC function evaluated by mutational analysis of Brh2 in Ustilago maydis	5
The Sm core components of small nuclear ribonucleoproteins promote homologous recombination repair	5
Temporal and spatial dynamics of DNA double-strand break repair centers	5
Three targets in one complex: A molecular perspective of TFIIH in cancer therapy	5
C. elegans ribosomal protein S3 protects against H2O2-induced DNA damage and suppresses spontaneous mutations in yeast	5
Mechanism for R-loop formation remote from the transcription start site: Topological issues and possible facilitation by dissociation of RNA polymerase	5
Cockayne syndrome group B protein uses its DNA translocase activity to promote mitotic DNA synthesis	5
Holding it together: DNA end synapsis during non-homologous end joining	5
Interaction of mitoxantrone with abasic sites - DNA strand cleavage and inhibition of apurinic/apyrimidinic endonuclease 1, APE1	5
DNA Repair Capacity for Personalizing Risk and Treatment Response − Assay Development and Optimization in Human Peripheral Blood Mononuclear Cells (PBMCs)	5
The role of histone H3K36me3 writers, readers and erasers in maintaining genome stability	5
Transcription-coupled DNA double-strand break repair	5
Monitoring DNA polymerase β mitochondrial localization and dynamics	4
A-T neurodegeneration and DNA damage-induced transcriptional stress	4
Live cell transcription-coupled nucleotide excision repair dynamics revisited	4
Compared to other NHEJ factors, DNA-PK protein and RNA levels are markedly increased in all higher primates, but not in prosimians or other mammals	4
Editorial Board	4
Microglial inflammation in genome instability: A neurodegenerative perspective	4
The Ataxia-telangiectasia mutated (ATM) is the most important gene for repairing the DNA in Myelodysplastic Neoplasm	4
Targeting DNA damage sensors for cancer therapy	4
DNA repair pathways in the mitochondria	4
Phosphoregulation of the checkpoint kinase Mec1ATR	4
An open-source platform to quantify subnuclear foci and protein colocalization in response to replication stress	4
Histone and Chromatin Dynamics Facilitating DNA repair	4
Bulk synthesis and beyond: The roles of eukaryotic replicative DNA polymerases	4
The C-terminal tail of Rad17, iVERGE, binds the 9‒1‒1 complex independently of AAA+ ATPase domains to provide another clamp–loader interface	4
Partial deletions of the autoregulatory C-terminal domain of Artemis and their effect on its nuclease activity	4
Global screening of base excision repair in nucleosome core particles	4
Large-scale generation and phenotypic characterization of zebrafish CRISPR mutants of DNA repair genes	4
DNA damage-induced sumoylation of Sp1 induces its interaction with RNF4 and degradation in S phase to remove 53BP1 from DSBs and permit HR	4
UVSSA facilitates transcription-coupled repair of DNA interstrand crosslinks	4
Kinome-wide screening uncovers a role for Bromodomain Protein 3 in DNA double-stranded break repair	4
Editorial Board	4
Toxic R-loops: Cause or consequence of replication stress?	4
Multifunctional properties of Nej1XLF C-terminus promote end-joining and impact DNA double-strand break repair pathway choice	4
Functions of PMS2 and MLH1 important for regulation of divergent repeat-mediated deletions	4
Cutting-edge perspectives in genomic maintenance VIII	4
Joining of DNA breaks- interplay between DNA ligases and poly (ADP-ribose) polymerases	4
Histone lysine modifying enzymes and their critical roles in DNA double-strand break repair	4
HOTAIR beyond repression: In protein degradation, inflammation, DNA damage response, and cell signaling	4
The analysis of protein recruitment to laser microirradiation-induced DNA damage in live cells: Best practices for data analysis	4
Non-canonical function of nuclear PTEN and its implication on tumorigenesis	4
Biochemical analysis of H2O2-induced mutation spectra revealed that multiple damages were involved in the mutational process	3
Mediator complex in transcription regulation and DNA repair: Relevance for human diseases	3
SMUG1 regulates fat homeostasis leading to a fatty liver phenotype in mice	3
Structure, function and evolution of the Helix-hairpin-Helix DNA glycosylase superfamily: Piecing together the evolutionary puzzle of DNA base damage repair mechanisms	3
A bibliometric analysis of research on R-loop: Landscapes, highlights and trending topics	3
Rrp1, Rrp2 and Uls1 – Yeast SWI2/SNF2 DNA dependent translocases in genome stability maintenance	3
Single-molecule toxicogenomics: Optical genome mapping of DNA-damage in nanochannel arrays	3
UBAP2/UBAP2L regulate UV-induced ubiquitylation of RNA polymerase II and are the human orthologues of yeast Def1	3
Temporal recruitment of base excision DNA repair factors in living cells in response to different micro-irradiation DNA damage protocols	3
Evolution of the triplet BRCT domain	3
O-GlcNAc transferase is important for homology-directed repair	3
53BP1-the ‘Pandora’s box’ of genome integrity	3
Histone variants: The unsung guardians of the genome	3
Can neural signals override cellular decisions in the presence of DNA damage?	3
Post-translational regulation of Tyrosyl-DNA phosphodiesterase (TDP1 and TDP2) for the repair of the trapped topoisomerase-DNA covalent complex	3
The meiosis-specific MEIOB–SPATA22 complex cooperates with RPA to form a compacted mixed MEIOB/SPATA22/RPA/ssDNA complex	3
Spontaneous and salt stress-induced molecular instability in the progeny of MSH7 deficient Arabidopsis thaliana plants	3
Overexpression of the WWE domain of RNF146 modulates poly-(ADP)-ribose dynamics at sites of DNA damage	3
Cancer testis antigens and genomic instability: More than immunology	3
The C-terminal domain of Arabidopsis ROS1 DNA demethylase interacts with histone H3 and is required for DNA binding and catalytic activity	3
‘From R-lupus to cancer’: Reviewing the role of R-loops in innate immune responses	3
Fully automated counting of DNA damage foci in tumor cell culture: A matter of cell separation	3
FAM21 interacts with Ku to promote the localization of WASH to DNA double strand break sites	3
Genomic stress and impaired DNA repair in Alzheimer disease	3
FBH1 deficiency sensitizes cells to WEE1 inhibition by promoting mitotic catastrophe	3
Clinical evidence for a role of E2F1-induced replication stress in modulating tumor mutational burden and immune microenvironment	3
DNA repair deficiencies and neurodegeneration	3
mTOR pathway and DNA damage response: A therapeutic strategy in cancer therapy	3
Daughter-strand gaps in DNA replication – substrates of lesion processing and initiators of distress signalling	3
The DNA damage induced immune response: Implications for cancer therapy	3
Editorial	3
Lawrence H. Thompson: A life of bikes, birds, and DNA repair (1941–2024)	3
The evolving complexity of DNA damage foci: RNA, condensates and chromatin in DNA double-strand break repair	3