OOIR: Observatory of International Research

Papers

(The TQCC of DNA Repair is 8. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2022-06-01 to 2026-06-01.)

Article	Citations
Active genome integrity	64
Contents of previous 3 special issues in this series of perspectives	56
Regulatory apoptotic fragment of PARP1 complements catalytic fragment for PAR and DNA-dependent activity but inhibits DNA-induced catalytic stimulation of PARP2	53
DNA polymerase λ Loop1 variant yields unexpected gain-of-function capabilities in nonhomologous end-joining	45
Building an integrated view of R-loops, transcription, and chromatin	41
Spatial mapping of the DNA adducts in cancer	40
Suppressors of Blm-deficiency identify three novel proteins that facilitate DNA repair in Ustilago maydis	37
Functional defects of cancer-associated MDC1 mutations in DNA damage repair	35
Activation of Escherichia coli RecA* in recA730 lexA+ and recA730 lexA(Def) strain backgrounds	28
Editors’ note Penny Jeggo and Bennett Van Houten	27
Single-molecule imaging of genome maintenance proteins encountering specific DNA sequences and structures	26
Single-molecule approaches for DNA damage detection and repair: A focus on Repair Assisted Damage Detection (RADD)	26
From cooperation to conflicts – A complicated relationship between transcription and replication	26
The role of human PrimPol active site residue Gln48 in catalysis and complex formation with DNA	24
Harnessing R-loop dynamics: Challenging cancer therapy resistance	23
The burden of overweight: Higher body mass index, but not vital exhaustion, is associated with higher DNA damage and lower DNA repair capacity	23
A novel Family V uracil DNA glycosylase from Sulfolobus islandicus REY15A	22
Irc20 modulates LOH frequency and distribution in S. cerevisiae	22
Stressed? Break-induced replication comes to the rescue!	22
Editorial Board	21
Editorial Board	21
Chromatin meets the cytoskeleton: the importance of nuclear actin dynamics and associated motors for genome stability	20
PARP inhibitors in ovarian cancer: Mechanisms of resistance and implications to therapy	19
PARP1-PROTACs providing novel opportunities in precision oncology by targeting DNA damage response	18
What are the DNA lesions underlying formaldehyde toxicity?	18

Corruption of DNA end-joining in mammalian chromosomes by progerin expression	18
DNA damage response and genomic instability disorder: Meeting report of the 20th Ataxia-Telangiectasia Workshop (ATW-2024) in conjunction with the 15th international symposium on DNA damage response &	18
The B cell dilemma: Diversity or fidelity?	18
Comparing Mfd- and UvrD-dependent models of transcription coupled DNA repair in live Escherichia coli using single-molecule tracking	18
Editorial Board	17
Positioning loss of PARP1 activity as the central toxic event in BRCA-deficient cancer	17
DNA repair-related heritable photosensitivity syndromes: Mutation landscape in a multiethnic cohort of 17 multigenerational families with high degree of consanguinity	17
Targeting base excision repair in precision oncology	17
The interferon response at the intersection of genome integrity and innate immunity	16
Double-strand break repair and mis-repair in 3D	16
The role of SLFN11 in DNA replication stress response and its implications for the Fanconi anemia pathway	16
The differential roles of rad9 alternatively spliced forms in double- strand DNA break repair during Drosophila meiosis	16
Protein-protein interactions in the core nucleotide excision repair pathway	15
Editorial Board	15
Phospho-SIM and exon8b of PML protein regulate formation of doxorubicin-induced rDNA-PML compartment	15
DNA synthesis across DNA hairpins by human PrimPol	15
Metazoan nuclear pore complexes in gene regulation and genome stability	15
Richard Gatti: From concert pianist to bone marrow transplants and the DNA damage response syndrome, ataxia-telangiectasia	14
Chromosomal single-strand break repair and neurological disease: Implications on transcription and emerging genomic tools	14
Loss of alkyladenine DNA glycosylase alters gene expression in the developing mouse brain and leads to reduced anxiety and improved memory	14
Centromere: A Trojan horse for genome stability	14
The multifaceted roles of the Ctf4 replisome hub in the maintenance of genome integrity	14
NBS1 binds directly to TOPBP1 via disparate interactions between the NBS1 BRCT1 domain and the TOPBP1 BRCT1 and BRCT2 domains	13
Impairment of the non-catalytic subunit Dpb2 of DNA Pol ɛ results in increased involvement of Pol δ on the leading strand	13
Using the safety scissors: DNA resection regulation at DNA double-strand breaks and telomeres	13
Variation in G-quadruplex sequence and topology differentially impacts human DNA polymerase fidelity	13
One-ended and two-ended breaks at nickase-broken replication forks	13
Inhibition of human DNA alkylation damage repair enzyme ALKBH2 by HIV protease inhibitor ritonavir	13
Long-range PCR as a tool for evaluating mitochondrial DNA damage: Principles, benefits, and limitations of the technique	13
Endogenous base damage as a driver of genomic instability in homologous recombination-deficient cancers	13
Cutting Edge Perspectives in genome maintenance X	13
Somatic mutation patterns at Ig and Non-Ig Loci	12
miR-185–5p rewires cisplatin resistance by restoring miR-203a-3p expression via downregulation of SOX9	12
Biochemical characterization and mutational analysis of a mismatch glycosylase from the hyperthermophilic euryarchaeon Thermococcus barophilus Ch5	12
Altered pathways in Cockayne syndrome: Involvement of MAPK, PI3K-Akt, extracellular matrix, inflammation, and neuronal signaling	12
Altered lipid profile in mice lacking the DNA repair protein ERCC1	11
Reversible association of ubiquitin with PCNA is important for template switching in S. cerevisiae	11
Presenilin-1, mutated in familial Alzheimer’s disease, maintains genome stability via a γ-secretase dependent way	11
Corrigendum to “Role of NEIL1 in genome maintenance” [DNA Repair 148 (2025) 103820]	11
Frailty, sex, and poverty are associated with DNA damage and repair in frail, middle-aged urban adults	11
BRCA1 and BRCA2 in DNA damage and replication stress response: Insights into their functions, mechanisms, and implications for cancer treatment	11
Weaponizing CRISPR/Cas9 for selective elimination of cells with an aberrant genome	11
How DNA secondary structures drive replication fork instability	11
Editorial Board	10
DNA Repair Special Issue: Genome maintenance pathways in cancer - etiology, biomarkers and targets	10
TFIIH central activity in nucleotide excision repair to prevent disease	10
Contents of previous 3 special issues in this series of perspectives	10
Oncometabolite 2-hydroxyglutarate suppresses basal protein levels of DNA polymerase beta that enhances alkylating agent and PARG inhibition induced cytotoxicity	10
RNF4 prevents genomic instability caused by chronic DNA under-replication	10
The flap endonuclease-1 mediated maturation of Okazaki fragments is critical for the cellular tolerance to remdesivir	10

Insight into meiotic DNA end resection: Mechanisms and regulation	10
A moving target for drug discovery: Structure activity relationship and many genome (de)stabilizing functions of the RAD52 protein	10
C-terminal residues of DNA polymerase β and E3 ligase required for ubiquitin-linked proteolysis of oxidative DNA-protein crosslinks	10
Regulation of DNA damage-induced HLA class I presentation	9
A special issue: DNA damage response in disease and therapy	9
Therapeutic targeting of mismatch repair proteins in triplet repeat expansion diseases	9
Remdesivir triphosphate is a valid substrate to initiate synthesis of DNA primers by human PrimPol	9
KBM-mediated interactions with KU80 promote cellular resistance to DNA replication stress in CHO cells	9
USP1 in regulation of DNA repair pathways	9
Probing the structure and function of polymerase θ helicase-like domain	9
Small-molecule activator of SMUG1 enhances repair of pyrimidine lesions in DNA	9
Obituary	9
Mlh1 interacts with both Msh2 and Msh6 for recruitment during mismatch repair	9
Positive and negative regulators of RAD51/DMC1 in homologous recombination and DNA replication	9
Mechanisms and regulation of replication fork reversal	9
Phylogenetic distribution, structural analysis and interaction of nucleotide excision repair proteins in cyanobacteria	8
Variants in the first methionine of RAD51C are homologous recombination proficient due to an alternative start site	8
Genome integrity and inflammation in the nervous system	8
DNA lesions that block transcription induce the death of Trypanosoma cruzi via ATR activation, which is dependent on the presence of R-loops	8
Real-time single-molecule visualization using DNA curtains reveals the molecular mechanisms underlying DNA repair pathways	8
SMC-5/6 complex subunit NSE-1 plays a crucial role in meiosis and DNA repair in Caenorhabditis elegans	8
Discovery of KPT-6566 as STAG1/2 Inhibitor sensitizing PARP and NHEJ Inhibitors to suppress tumor cells growth in vitro	8
DONSON: Slding in 2 the limelight	8
Screening of glycosylase activity on oxidative derivatives of methylcytosine: Pedobacter heparinus SMUG2 as a formylcytosine- and carboxylcytosine-DNA glycosylase	8
Why the ROS matters: One-electron oxidants focus DNA damage and repair on G-quadruplexes for gene regulation	8
Tribute to life and science of Grigory (Gosha) Dianov	8
Emerging connections: Poly(ADP-ribose), FET proteins and RNA in the regulation of DNA damage condensates	8
Cutting edge perspectives in genome maintenance XI	8
The replication stress response: Mechanisms and functions	8
Pold4 subunit of replicative polymerase δ promotes fork slowing at broken templates	8
Biochemical characterization and mutational studies of endonuclease Q from the hyperthermophilic euryarchaeon Thermococcus gammatolerans	8
Compartmentalization of the DNA damage response: Mechanisms and functions	8
PARPs and ADP-ribosyl hydrolases in cancer therapy: From drug targets to biomarkers	8