OOIR: Observatory of International Research

Papers

(The TQCC of DNA Repair is 9. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2020-05-01 to 2024-05-01.)

Article	Citations
New insights into abasic site repair and tolerance	89
Roles for 53BP1 in the repair of radiation-induced DNA double strand breaks	62
Excision repair of topoisomerase DNA-protein crosslinks (TOP-DPC)	61
Mammalian DNA base excision repair: Dancing in the moonlight	59
The MRE11 complex: A versatile toolkit for the repair of broken DNA	58
Biomolecular condensates at sites of DNA damage: More than just a phase	54
Defining R-loop classes and their contributions to genome instability	53
ADP-ribosylation of DNA and RNA	52
Debulking of topoisomerase DNA-protein crosslinks (TOP-DPC) by the proteasome, non-proteasomal and non-proteolytic pathways	49
Molecular origins of APOBEC-associated mutations in cancer	47
Recent advances in γH2AX biomarker-based genotoxicity assays: A marker of DNA damage and repair	47
DNA mismatch repair-dependent DNA damage responses and cancer	42
Envisioning how the prototypic molecular machine TFIIH functions in transcription initiation and DNA repair	39
The recent advances in non-homologous end-joining through the lens of lymphocyte development	36
PARP1: Structural insights and pharmacological targets for inhibition	35
Towards DNA-damage induced autophagy: A Boolean model of p53-induced cell fate mechanisms	34
The cerebellar degeneration in ataxia-telangiectasia: A case for genome instability	34
Towards a comprehensive view of 8-oxo-7,8-dihydro-2’-deoxyguanosine: Highlighting the intertwined roles of DNA damage and epigenetics in genomic instability	33
Strand discrimination in DNA mismatch repair	32
Targeting Wee1 kinase as a therapeutic approach in Hematological Malignancies	32
How to fix DNA-protein crosslinks	30
Consequences of compromised mitochondrial genome integrity	30
Coping with RNA damage with a focus on APE1, a BER enzyme at the crossroad between DNA damage repair and RNA processing/decay	29
The role of the SWI/SNF chromatin remodelling complex in the response to DNA double strand breaks	28
Role of mtDNA disturbances in the pathogenesis of Alzheimer’s and Parkinson’s disease	27

Roles for MDC1 in cancer development and treatment	27
PARPs’ impact on base excision DNA repair	27
Dealing with transcription-blocking DNA damage: Repair mechanisms, RNA polymerase II processing and human disorders	27
Revisiting the BRCA-pathway through the lens of replication gap suppression	27
Human DNA ligases in replication and repair	26
TREX1 – Apex predator of cytosolic DNA metabolism	26
P53 in the impaired lungs	26
Time for remodeling: SNF2-family DNA translocases in replication fork metabolism and human disease	26
XRCC1 – Strategies for coordinating and assembling a versatile DNA damage response	25
The evolving complexity of DNA damage foci: RNA, condensates and chromatin in DNA double-strand break repair	25
The SNM1A DNA repair nuclease	24
Hypermutation in single-stranded DNA	24
NAD+-mediated regulation of mammalian base excision repair	24
EXO1: A tightly regulated nuclease	23
Signaling pathways involved in cell cycle arrest during the DNA breaks	23
DNA damage response and repair in osteosarcoma: Defects, regulation and therapeutic implications	23
PRMT1 is critical to FEN1 expression and drug resistance in lung cancer cells	22
Cellular response to endogenous DNA damage: DNA base modifications in gene expression regulation	22
Transcription-coupled nucleotide excision repair: New insights revealed by genomic approaches	22
Expanding molecular roles of UV-DDB: Shining light on genome stability and cancer	21
DNA helicases and their roles in cancer	21
NTHL1 in genomic integrity, aging and cancer	21
Twenty years of t-loops: A case study for the importance of collaboration in molecular biology	21
Phosphorylation-dependent assembly of DNA damage response systems and the central roles of TOPBP1	21
Impact of circadian disruption on health; SIRT1 and Telomeres	20
Two main mutational processes operate in the absence of DNA mismatch repair	19
GTPases, genome, actin: A hidden story in DNA damage response and repair mechanisms	19
Transcription coupled base excision repair in mammalian cells: So little is known and so much to uncover	19
The dark side of homology-directed repair	19
Chromosome breaks generated by low doses of ionizing radiation in G2-phase are processed exclusively by gene conversion	19
Understanding the sequence and structural context effects in oxidative DNA damage repair	18
Mechanisms of direct replication restart at stressed replisomes	18
Formation and repair of unavoidable, endogenous interstrand cross-links in cellular DNA	18
PARP1-mediated PARylation of TonEBP prevents R-loop–associated DNA damage	17
Pol β gap filling, DNA ligation and substrate-product channeling during base excision repair opposite oxidized 5-methylcytosine modifications	17
Increased DNA repair capacity augments resistance of glioblastoma cells to photodynamic therapy	17
Biochemical analysis of TOPBP1 oligomerization	16
The dual role of DNA repair protein MGMT in cancer prevention and treatment	16
C17orf53 is identified as a novel gene involved in inter-strand crosslink repair	16
Untangling trapped topoisomerases with tyrosyl-DNA phosphodiesterases	16
Structure, function and evolution of the Helix-hairpin-Helix DNA glycosylase superfamily: Piecing together the evolutionary puzzle of DNA base damage repair mechanisms	16
The role of telomeres and telomerase in the senescence of postmitotic cells	16
Molecular and structural characterization of disease-associated APE1 polymorphisms	16
Tyrosyl-DNA phosphodiesterase 2 (TDP2) repairs topoisomerase 1 DNA-protein crosslinks and 3′-blocking lesions in the absence of tyrosyl-DNA phosphodiesterase 1 (TDP1)	16
Large dataset of octocoral mitochondrial genomes provides new insights into mt-mutS evolution and function	16
Significance and limitations of the use of next-generation sequencing technologies for detecting mutational signatures	16
Toxic R-loops: Cause or consequence of replication stress?	16
Cancer testis antigens and genomic instability: More than immunology	15
Helicobacter pylori severely reduces expression of DNA repair proteins PMS2 and ERCC1 in gastritis and gastric cancer	15
The role of DNA damage response in chemo- and radio-resistance of cancer cells: Can DDR inhibitors sole the problem?	15

Structural biology of DNA abasic site protection by SRAP proteins	15
Replication initiation: Implications in genome integrity	15
Molecular basis for the MacroD1-mediated hydrolysis of ADP-ribosylation	15
Daughter-strand gaps in DNA replication – substrates of lesion processing and initiators of distress signalling	15
CST in maintaining genome stability: Beyond telomeres	15
The role of histone H3K36me3 writers, readers and erasers in maintaining genome stability	14
HOTAIR beyond repression: In protein degradation, inflammation, DNA damage response, and cell signaling	14
DNA damage response and breast cancer development: Possible therapeutic applications of ATR, ATM, PARP, BRCA1 inhibition	13
Compromised repair of radiation-induced DNA double-strand breaks in Fanconi anemia fibroblasts in G2	13
Role of histone acetyltransferases MOF and Tip60 in genome stability	13
RNA helicase, DDX3X, is actively recruited to sites of DNA damage in live cells	13
Transcription-coupled DNA double-strand break repair	13
The meiosis-specific MEIOB–SPATA22 complex cooperates with RPA to form a compacted mixed MEIOB/SPATA22/RPA/ssDNA complex	13
Transcription-coupled repair and the transcriptional response to UV-Irradiation	13
Large-scale generation and phenotypic characterization of zebrafish CRISPR mutants of DNA repair genes	13
mTOR pathway and DNA damage response: A therapeutic strategy in cancer therapy	13
New twists to the ALTernative endings at telomeres	13
Understanding the DNA double-strand break repair and its therapeutic implications	13
Perspectives on formaldehyde dysregulation: Mitochondrial DNA damage and repair in mammalian cells	12
Non-canonical function of nuclear PTEN and its implication on tumorigenesis	12
Cyclin-dependent kinase inhibitors (CDKIs) and the DNA damage response: The link between signaling pathways and cancer	12
Olaparib enhances curcumin-mediated apoptosis in oral cancer cells by inducing PARP trapping through modulation of BER and chromatin assembly	12
Double-strand breaks: When DNA repair events accidentally meet	12
Chaperoning histones at the DNA repair dance	12
Double strand break (DSB) repair in Cyanobacteria: Understanding the process in an ancient organism	12
Regulation of UV damage repair in quiescent yeast cells	12
Impacts of chromatin dynamics and compartmentalization on DNA repair	12
MicroRNAs and the DNA damage response: How is cell fate determined?	11
miR-197-5p increases Doxorubicin-mediated anticancer cytotoxicity of HT1080 fibrosarcoma cells by decreasing drug efflux	11
DNA polymerase β outperforms DNA polymerase γ in key mitochondrial base excision repair activities	11
Non-canonical interaction of DNA repair proteins with intact and cleaved AP sites	11
The cross-talk between signaling pathways, noncoding RNAs and DNA damage response: Emerging players in cancer progression	11
Transcriptional dysregulation of base excision repair proteins in breast cancer	11
DNA double-strand break repair in male germ cells during spermatogenesis and its association with male infertility development	11
DNA damage response and PD-1/PD-L1 pathway in ovarian cancer	11
USP13 regulates the replication stress response by deubiquitinating TopBP1	11
Fine-tuning of DNA base excision/strand break repair via acetylation	11
Alteration of genetic recombination and double-strand break repair in human cells by progerin expression	11
DNA repair pathways as guardians of the genome: Therapeutic potential and possible prognostic role in hematologic neoplasms	11
Proficiency in homologous recombination repair is prerequisite for activation of G2-checkpoint at low radiation doses	10
DNA mismatch repair in the chromatin context: Mechanisms and therapeutic potential	10
Molecular analysis directs the prognosis, management and treatment of patients with xeroderma pigmentosum	10
The “adductome”: A limited repertoire of adducted proteins in human cells	10
The multifaceted roles of DNA repair and replication proteins in aging and obesity	10
Sp1-dependent recruitment of the histone acetylase p300 to DSBs facilitates chromatin remodeling and recruitment of the NHEJ repair factor Ku70	10
Post-translational modification of factors involved in homologous recombination	10
Requirements for PARP-1 covalent crosslinking to DNA (PARP-1 DPC)	10
PCNA, a focus on replication stress and the alternative lengthening of telomeres pathway	9
G-quadruplex resolution: From molecular mechanisms to physiological relevance	9
Telomere replication—When the going gets tough	9
Structural determinants of nucleobase modification recognition in the AlkB family of dioxygenases	9
The DNA ligands Arg47 and Arg76 are crucial for catalysis by human PrimPol	9
Genome maintenance during embryogenesis	9
To indel or not to indel: Factors influencing mutagenesis during chromosomal break end joining	9
DNA damage-induced sumoylation of Sp1 induces its interaction with RNF4 and degradation in S phase to remove 53BP1 from DSBs and permit HR	9
Sequence context effects of replication of Fapy•dG in three mutational hot spot sequences of the p53 gene in human cells	9
Size-dependent antirecombinogenic effect of short spacers on palindrome recombinogenicity	9
Modulation of immune responses by DNA damage signaling	9
Hydroxychloroquine induces oxidative DNA damage and mutation in mammalian cells	9