OOIR: Observatory of International Research

Papers

(The TQCC of DNA Repair is 7. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-08-01 to 2025-08-01.)

Article	Citations
Spatial mapping of the DNA adducts in cancer	89
Functional defects of cancer-associated MDC1 mutations in DNA damage repair	84
Regulatory apoptotic fragment of PARP1 complements catalytic fragment for PAR and DNA-dependent activity but inhibits DNA-induced catalytic stimulation of PARP2	80
Suppressors of Blm-deficiency identify three novel proteins that facilitate DNA repair in Ustilago maydis	75
Active genome integrity	50
DNA polymerase λ Loop1 variant yields unexpected gain-of-function capabilities in nonhomologous end-joining	47
Building an integrated view of R-loops, transcription, and chromatin	46
Loss of an ABC transporter in Arabidopsis thaliana confers hypersensitivity to the anti-cancer drug bleomycin	45
Acetylation of H3K56 orchestrates UV-responsive chromatin events that generate DNA accessibility during Nucleotide Excision Repair	39
Editors’ note Penny Jeggo and Bennett Van Houten	37
Harnessing R-loop dynamics: Challenging cancer therapy resistance	36
Editorial Board	36
Single-molecule approaches for DNA damage detection and repair: A focus on Repair Assisted Damage Detection (RADD)	35
Single-molecule imaging of genome maintenance proteins encountering specific DNA sequences and structures	34
The burden of overweight: Higher body mass index, but not vital exhaustion, is associated with higher DNA damage and lower DNA repair capacity	34
From cooperation to conflicts – A complicated relationship between transcription and replication	32
The role of human PrimPol active site residue Gln48 in catalysis and complex formation with DNA	31
Stressed? Break-induced replication comes to the rescue!	31
Corruption of DNA end-joining in mammalian chromosomes by progerin expression	30
A novel Family V uracil DNA glycosylase from Sulfolobus islandicus REY15A	29
Irc20 modulates LOH frequency and distribution in S. cerevisiae	28
PARP1-PROTACs providing novel opportunities in precision oncology by targeting DNA damage response	27
Editorial Board	27
Editorial Board	26
Editorial Board	26

Comparing Mfd- and UvrD-dependent models of transcription coupled DNA repair in live Escherichia coli using single-molecule tracking	24
Targeting base excision repair in precision oncology	24
PARP inhibitors in ovarian cancer: Mechanisms of resistance and implications to therapy	23
What are the DNA lesions underlying formaldehyde toxicity?	23
DNA damage response and genomic instability disorder: Meeting report of the 20th Ataxia-Telangiectasia Workshop (ATW-2024) in conjunction with the 15th international symposium on DNA damage response &	22
rumAB genes from SXT/R391 ICEs confer UV-induced mutability to Proteus mirabilis hosts and improve conjugation after UV irradiation	22
Editorial Board	21
Positioning loss of PARP1 activity as the central toxic event in BRCA-deficient cancer	21
DNA repair-related heritable photosensitivity syndromes: Mutation landscape in a multiethnic cohort of 17 multigenerational families with high degree of consanguinity	21
Chromatin meets the cytoskeleton: the importance of nuclear actin dynamics and associated motors for genome stability	21
DNA synthesis across DNA hairpins by human PrimPol	20
The role of SLFN11 in DNA replication stress response and its implications for the Fanconi anemia pathway	20
The interferon response at the intersection of genome integrity and innate immunity	19
Double-strand break repair and mis-repair in 3D	19
The differential roles of rad9 alternatively spliced forms in double- strand DNA break repair during Drosophila meiosis	19
The dark side of homology-directed repair	19
Phospho-SIM and exon8b of PML protein regulate formation of doxorubicin-induced rDNA-PML compartment	19
Protein-protein interactions in the core nucleotide excision repair pathway	18
ADP-ribosylation of DNA and RNA	18
Metazoan nuclear pore complexes in gene regulation and genome stability	18
Editorial Board	17
Damage-Net: A program for DNA repair meta-analysis identifies a network of novel repair genes that facilitate cancer evolution	17
Loss of alkyladenine DNA glycosylase alters gene expression in the developing mouse brain and leads to reduced anxiety and improved memory	17
NBS1 binds directly to TOPBP1 via disparate interactions between the NBS1 BRCT1 domain and the TOPBP1 BRCT1 and BRCT2 domains	17
Mutagenic repair of a ZFN-induced double-strand break in yeast: Effects of cleavage site sequence and spacer size	17
Strand discrimination in DNA mismatch repair	17
One-ended and two-ended breaks at nickase-broken replication forks	16
Large dataset of octocoral mitochondrial genomes provides new insights into mt-mutS evolution and function	16
Variation in G-quadruplex sequence and topology differentially impacts human DNA polymerase fidelity	16
Long-range PCR as a tool for evaluating mitochondrial DNA damage: Principles, benefits, and limitations of the technique	16
Recent advances in γH2AX biomarker-based genotoxicity assays: A marker of DNA damage and repair	16
XPA is susceptible to proteolytic cleavage by cathepsin L during lysis of quiescent cells	15
Endogenous base damage as a driver of genomic instability in homologous recombination-deficient cancers	15
Expression of BRCA1, BRCA2, RAD51, and other DSB repair factors is regulated by CRL4WDR70	15
Sequence context effects of replication of Fapy•dG in three mutational hot spot sequences of the p53 gene in human cells	15
The multifaceted roles of the Ctf4 replisome hub in the maintenance of genome integrity	15
Chromosomal single-strand break repair and neurological disease: Implications on transcription and emerging genomic tools	14
Yearly perspective from the Co-Editors in Chief	14
Camptothecin compromises transcription recovery and cell survival against cisplatin and ultraviolet irradiation regardless of transcription-coupled nucleotide excision repair	14
Centromere: A Trojan horse for genome stability	14
Using the safety scissors: DNA resection regulation at DNA double-strand breaks and telomeres	14
Cutting Edge Perspectives in genome maintenance X	14
miR-197-5p increases Doxorubicin-mediated anticancer cytotoxicity of HT1080 fibrosarcoma cells by decreasing drug efflux	13
TOPBP1 regulates resistance of gastric cancer to oxaliplatin by promoting transcription of PARP1	13
DNA glycosylase deficiency leads to decreased severity of lupus in the Polb-Y265C mouse model	13
The life and legacy of Sam Wilson (1939–2021)	13
miR-185–5p rewires cisplatin resistance by restoring miR-203a-3p expression via downregulation of SOX9	13
Somatic mutation patterns at Ig and Non-Ig Loci	13
Impairment of the non-catalytic subunit Dpb2 of DNA Pol ɛ results in increased involvement of Pol δ on the leading strand	13
Inhibition of human DNA alkylation damage repair enzyme ALKBH2 by HIV protease inhibitor ritonavir	13

Altered pathways in Cockayne syndrome: Involvement of MAPK, PI3K-Akt, extracellular matrix, inflammation, and neuronal signaling	13
DNA polymerase delta Exo domain stabilizes mononucleotide microsatellites in human cells	13
Biochemical characterization and mutational analysis of a mismatch glycosylase from the hyperthermophilic euryarchaeon Thermococcus barophilus Ch5	13
Reversible association of ubiquitin with PCNA is important for template switching in S. cerevisiae	12
Increased contribution of DNA polymerase delta to the leading strand replication in yeast with an impaired CMG helicase complex	12
Weaponizing CRISPR/Cas9 for selective elimination of cells with an aberrant genome	12
BRCA1 and BRCA2 in DNA damage and replication stress response: Insights into their functions, mechanisms, and implications for cancer treatment	12
The flap endonuclease-1 mediated maturation of Okazaki fragments is critical for the cellular tolerance to remdesivir	11
Editorial Board	11
Corrigendum to “Role of NEIL1 in genome maintenance” [DNA Repair 148 (2025) 103820]	11
Editorial Board	11
Frailty, sex, and poverty are associated with DNA damage and repair in frail, middle-aged urban adults	11
Contents of previous 3 special issues in this series of perspectives	11
MicroRNAs and the DNA damage response: How is cell fate determined?	11
C-terminal residues of DNA polymerase β and E3 ligase required for ubiquitin-linked proteolysis of oxidative DNA-protein crosslinks	10
Oncometabolite 2-hydroxyglutarate suppresses basal protein levels of DNA polymerase beta that enhances alkylating agent and PARG inhibition induced cytotoxicity	10
Multi-omic analysis of altered transcriptome and epigenetic signatures in the UV-induced DNA damage response	10
RNF4 prevents genomic instability caused by chronic DNA under-replication	10
Impact of DNA sequences on DNA ‘opening’ by the Rad4/XPC nucleotide excision repair complex	10
Genetic polymorphisms in DNA repair genes and hepatocellular carcinoma risk	10
Small-molecule activator of SMUG1 enhances repair of pyrimidine lesions in DNA	9
TFIIH central activity in nucleotide excision repair to prevent disease	9
Remdesivir triphosphate is a valid substrate to initiate synthesis of DNA primers by human PrimPol	9
CometChip enables parallel analysis of multiple DNA repair activities	9
Mechanisms and regulation of replication fork reversal	9
Therapeutic targeting of mismatch repair proteins in triplet repeat expansion diseases	9
Presenilin-1, mutated in familial Alzheimer’s disease, maintains genome stability via a γ-secretase dependent way	9
A moving target for drug discovery: Structure activity relationship and many genome (de)stabilizing functions of the RAD52 protein	9
Determination of DNA lesion bypass using a ChIP-based assay	9
KBM-mediated interactions with KU80 promote cellular resistance to DNA replication stress in CHO cells	8
Incorporation of 5’,8-cyclo-2’deoxyadenosines by DNA repair polymerases via base excision repair	8
USP1 in regulation of DNA repair pathways	8
The mRNA tether model for activation-induced deaminase and its relevance for Ig somatic hypermutation and class switch recombination	8
Obituary	8
Phosphorylation-dependent assembly of DNA damage response systems and the central roles of TOPBP1	8
Positive and negative regulators of RAD51/DMC1 in homologous recombination and DNA replication	8
Regulation of DNA damage-induced HLA class I presentation	8
Processes shaping cancer genomes – From mitotic defects to chromosomal rearrangements	8
Probing the structure and function of polymerase θ helicase-like domain	8
Mlh1 interacts with both Msh2 and Msh6 for recruitment during mismatch repair	8
Editorial Board	8
DONSON: Slding in 2 the limelight	7
Real-time single-molecule visualization using DNA curtains reveals the molecular mechanisms underlying DNA repair pathways	7
Emerging connections: Poly(ADP-ribose), FET proteins and RNA in the regulation of DNA damage condensates	7
Phylogenetic distribution, structural analysis and interaction of nucleotide excision repair proteins in cyanobacteria	7
Compartmentalization of the DNA damage response: Mechanisms and functions	7
Biochemical characterization and mutational studies of endonuclease Q from the hyperthermophilic euryarchaeon Thermococcus gammatolerans	7
Pold4 subunit of replicative polymerase δ promotes fork slowing at broken templates	7
Mouse Embryonic Fibroblasts Isolated From Nthl1 D227Y Knockin Mice Exhibit Defective DNA Repair and Increased Genome Instability	7
Low and high doses of ionizing radiation evoke discrete global (phospho)proteome responses	7
SMC-5/6 complex subunit NSE-1 plays a crucial role in meiosis and DNA repair in Caenorhabditis elegans	7
Cutting edge perspectives in genome maintenance XI	7
Genome integrity and inflammation in the nervous system	7
Corrigendum to “Quantitative assessment of HR and NHEJ activities via CRISPR/Cas9-induced oligodeoxynucleotide-mediated DSB repair” [DNA Repair 70 (2018) 67–71]	7
Screening of glycosylase activity on oxidative derivatives of methylcytosine: Pedobacter heparinus SMUG2 as a formylcytosine- and carboxylcytosine-DNA glycosylase	7
Variants in the first methionine of RAD51C are homologous recombination proficient due to an alternative start site	7
PARPs and ADP-ribosyl hydrolases in cancer therapy: From drug targets to biomarkers	7
The replication stress response: Mechanisms and functions	7
Why the ROS matters: One-electron oxidants focus DNA damage and repair on G-quadruplexes for gene regulation	7
DNA lesions that block transcription induce the death of Trypanosoma cruzi via ATR activation, which is dependent on the presence of R-loops	7