OOIR: Observatory of International Research

Papers

(The TQCC of DNA Repair is 7. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2022-01-01 to 2026-01-01.)

Article	Citations
Active genome integrity	50
Suppressors of Blm-deficiency identify three novel proteins that facilitate DNA repair in Ustilago maydis	45
Spatial mapping of the DNA adducts in cancer	43
Functional defects of cancer-associated MDC1 mutations in DNA damage repair	37
DNA polymerase λ Loop1 variant yields unexpected gain-of-function capabilities in nonhomologous end-joining	36
Regulatory apoptotic fragment of PARP1 complements catalytic fragment for PAR and DNA-dependent activity but inhibits DNA-induced catalytic stimulation of PARP2	36
Building an integrated view of R-loops, transcription, and chromatin	34
Editors’ note Penny Jeggo and Bennett Van Houten	32
Contents of previous 3 special issues in this series of perspectives	32
Single-molecule approaches for DNA damage detection and repair: A focus on Repair Assisted Damage Detection (RADD)	30
Harnessing R-loop dynamics: Challenging cancer therapy resistance	25
The role of human PrimPol active site residue Gln48 in catalysis and complex formation with DNA	24
Acetylation of H3K56 orchestrates UV-responsive chromatin events that generate DNA accessibility during Nucleotide Excision Repair	23
From cooperation to conflicts – A complicated relationship between transcription and replication	21
Single-molecule imaging of genome maintenance proteins encountering specific DNA sequences and structures	21
The burden of overweight: Higher body mass index, but not vital exhaustion, is associated with higher DNA damage and lower DNA repair capacity	21
Stressed? Break-induced replication comes to the rescue!	21
Irc20 modulates LOH frequency and distribution in S. cerevisiae	20
The B cell dilemma: Diversity or fidelity?	19
rumAB genes from SXT/R391 ICEs confer UV-induced mutability to Proteus mirabilis hosts and improve conjugation after UV irradiation	19
A novel Family V uracil DNA glycosylase from Sulfolobus islandicus REY15A	19
Corruption of DNA end-joining in mammalian chromosomes by progerin expression	17
Editorial Board	17
Editorial Board	17
Editorial Board	17

Positioning loss of PARP1 activity as the central toxic event in BRCA-deficient cancer	16
DNA damage response and genomic instability disorder: Meeting report of the 20th Ataxia-Telangiectasia Workshop (ATW-2024) in conjunction with the 15th international symposium on DNA damage response &	16
What are the DNA lesions underlying formaldehyde toxicity?	16
PARP1-PROTACs providing novel opportunities in precision oncology by targeting DNA damage response	16
Comparing Mfd- and UvrD-dependent models of transcription coupled DNA repair in live Escherichia coli using single-molecule tracking	16
Chromatin meets the cytoskeleton: the importance of nuclear actin dynamics and associated motors for genome stability	15
PARP inhibitors in ovarian cancer: Mechanisms of resistance and implications to therapy	15
Targeting base excision repair in precision oncology	15
DNA synthesis across DNA hairpins by human PrimPol	15
The role of SLFN11 in DNA replication stress response and its implications for the Fanconi anemia pathway	14
DNA repair-related heritable photosensitivity syndromes: Mutation landscape in a multiethnic cohort of 17 multigenerational families with high degree of consanguinity	14
Metazoan nuclear pore complexes in gene regulation and genome stability	14
Protein-protein interactions in the core nucleotide excision repair pathway	14
Phospho-SIM and exon8b of PML protein regulate formation of doxorubicin-induced rDNA-PML compartment	14
The differential roles of rad9 alternatively spliced forms in double- strand DNA break repair during Drosophila meiosis	14
Double-strand break repair and mis-repair in 3D	14
Editorial Board	14
The interferon response at the intersection of genome integrity and innate immunity	14
Chromosomal single-strand break repair and neurological disease: Implications on transcription and emerging genomic tools	13
Loss of alkyladenine DNA glycosylase alters gene expression in the developing mouse brain and leads to reduced anxiety and improved memory	13
Camptothecin compromises transcription recovery and cell survival against cisplatin and ultraviolet irradiation regardless of transcription-coupled nucleotide excision repair	13
Using the safety scissors: DNA resection regulation at DNA double-strand breaks and telomeres	13
NBS1 binds directly to TOPBP1 via disparate interactions between the NBS1 BRCT1 domain and the TOPBP1 BRCT1 and BRCT2 domains	13
Long-range PCR as a tool for evaluating mitochondrial DNA damage: Principles, benefits, and limitations of the technique	13
The multifaceted roles of the Ctf4 replisome hub in the maintenance of genome integrity	13
XPA is susceptible to proteolytic cleavage by cathepsin L during lysis of quiescent cells	12
Variation in G-quadruplex sequence and topology differentially impacts human DNA polymerase fidelity	12
Centromere: A Trojan horse for genome stability	12
Endogenous base damage as a driver of genomic instability in homologous recombination-deficient cancers	12
Editorial Board	12
Large dataset of octocoral mitochondrial genomes provides new insights into mt-mutS evolution and function	12
miR-185–5p rewires cisplatin resistance by restoring miR-203a-3p expression via downregulation of SOX9	11
One-ended and two-ended breaks at nickase-broken replication forks	11
TOPBP1 regulates resistance of gastric cancer to oxaliplatin by promoting transcription of PARP1	11
Expression of BRCA1, BRCA2, RAD51, and other DSB repair factors is regulated by CRL4WDR70	11
Inhibition of human DNA alkylation damage repair enzyme ALKBH2 by HIV protease inhibitor ritonavir	10
Somatic mutation patterns at Ig and Non-Ig Loci	10
miR-197-5p increases Doxorubicin-mediated anticancer cytotoxicity of HT1080 fibrosarcoma cells by decreasing drug efflux	10
Cutting Edge Perspectives in genome maintenance X	10
Biochemical characterization and mutational analysis of a mismatch glycosylase from the hyperthermophilic euryarchaeon Thermococcus barophilus Ch5	10
Impairment of the non-catalytic subunit Dpb2 of DNA Pol ɛ results in increased involvement of Pol δ on the leading strand	10
Yearly perspective from the Co-Editors in Chief	10
Altered pathways in Cockayne syndrome: Involvement of MAPK, PI3K-Akt, extracellular matrix, inflammation, and neuronal signaling	10
Corrigendum to “Role of NEIL1 in genome maintenance” [DNA Repair 148 (2025) 103820]	9
Contents of previous 3 special issues in this series of perspectives	9
Small-molecule activator of SMUG1 enhances repair of pyrimidine lesions in DNA	9
Increased contribution of DNA polymerase delta to the leading strand replication in yeast with an impaired CMG helicase complex	9
Frailty, sex, and poverty are associated with DNA damage and repair in frail, middle-aged urban adults	9
Editorial Board	9
Insight into meiotic DNA end resection: Mechanisms and regulation	9

BRCA1 and BRCA2 in DNA damage and replication stress response: Insights into their functions, mechanisms, and implications for cancer treatment	9
Reversible association of ubiquitin with PCNA is important for template switching in S. cerevisiae	9
C-terminal residues of DNA polymerase β and E3 ligase required for ubiquitin-linked proteolysis of oxidative DNA-protein crosslinks	9
Editorial Board	9
Presenilin-1, mutated in familial Alzheimer’s disease, maintains genome stability via a γ-secretase dependent way	9
Weaponizing CRISPR/Cas9 for selective elimination of cells with an aberrant genome	9
A moving target for drug discovery: Structure activity relationship and many genome (de)stabilizing functions of the RAD52 protein	8
TFIIH central activity in nucleotide excision repair to prevent disease	8
Probing the structure and function of polymerase θ helicase-like domain	8
Regulation of DNA damage-induced HLA class I presentation	8
Remdesivir triphosphate is a valid substrate to initiate synthesis of DNA primers by human PrimPol	8
How DNA secondary structures drive replication fork instability	8
Oncometabolite 2-hydroxyglutarate suppresses basal protein levels of DNA polymerase beta that enhances alkylating agent and PARG inhibition induced cytotoxicity	8
Obituary	8
Mlh1 interacts with both Msh2 and Msh6 for recruitment during mismatch repair	8
RNF4 prevents genomic instability caused by chronic DNA under-replication	8
The flap endonuclease-1 mediated maturation of Okazaki fragments is critical for the cellular tolerance to remdesivir	8
Mechanisms and regulation of replication fork reversal	8
Incorporation of 5’,8-cyclo-2’deoxyadenosines by DNA repair polymerases via base excision repair	8
USP1 in regulation of DNA repair pathways	8
Therapeutic targeting of mismatch repair proteins in triplet repeat expansion diseases	7
Cutting edge perspectives in genome maintenance XI	7
Variants in the first methionine of RAD51C are homologous recombination proficient due to an alternative start site	7
DONSON: Slding in 2 the limelight	7
Discovery of KPT-6566 as STAG1/2 Inhibitor sensitizing PARP and NHEJ Inhibitors to suppress tumor cells growth in vitro	7
The mRNA tether model for activation-induced deaminase and its relevance for Ig somatic hypermutation and class switch recombination	7
SMC-5/6 complex subunit NSE-1 plays a crucial role in meiosis and DNA repair in Caenorhabditis elegans	7
KBM-mediated interactions with KU80 promote cellular resistance to DNA replication stress in CHO cells	7
Low and high doses of ionizing radiation evoke discrete global (phospho)proteome responses	7
DNA lesions that block transcription induce the death of Trypanosoma cruzi via ATR activation, which is dependent on the presence of R-loops	7
Pold4 subunit of replicative polymerase δ promotes fork slowing at broken templates	7
Genome integrity and inflammation in the nervous system	7
The replication stress response: Mechanisms and functions	7
Positive and negative regulators of RAD51/DMC1 in homologous recombination and DNA replication	7
Mouse Embryonic Fibroblasts Isolated From Nthl1 D227Y Knockin Mice Exhibit Defective DNA Repair and Increased Genome Instability	7
Screening of glycosylase activity on oxidative derivatives of methylcytosine: Pedobacter heparinus SMUG2 as a formylcytosine- and carboxylcytosine-DNA glycosylase	7
Biochemical characterization and mutational studies of endonuclease Q from the hyperthermophilic euryarchaeon Thermococcus gammatolerans	7
Emerging connections: Poly(ADP-ribose), FET proteins and RNA in the regulation of DNA damage condensates	7
PARPs and ADP-ribosyl hydrolases in cancer therapy: From drug targets to biomarkers	7