OOIR: Observatory of International Research

Papers

(The TQCC of DNA Repair is 8. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-06-01 to 2025-06-01.)

Article	Citations
Spatial mapping of the DNA adducts in cancer	81
Suppressors of Blm-deficiency identify three novel proteins that facilitate DNA repair in Ustilago maydis	80
Functional defects of cancer-associated MDC1 mutations in DNA damage repair	78
Regulatory apoptotic fragment of PARP1 complements catalytic fragment for PAR and DNA-dependent activity but inhibits DNA-induced catalytic stimulation of PARP2	72
Active genome integrity	59
DNA polymerase λ Loop1 variant yields unexpected gain-of-function capabilities in nonhomologous end-joining	49
Loss of an ABC transporter in Arabidopsis thaliana confers hypersensitivity to the anti-cancer drug bleomycin	45
Timely upstream events regulating nucleotide excision repair by ubiquitin-proteasome system: ubiquitin guides the way	44
Building an integrated view of R-loops, transcription, and chromatin	43
Single-molecule imaging of genome maintenance proteins encountering specific DNA sequences and structures	39
Acetylation of H3K56 orchestrates UV-responsive chromatin events that generate DNA accessibility during Nucleotide Excision Repair	36
Editorial Board	35
Single-molecule approaches for DNA damage detection and repair: A focus on Repair Assisted Damage Detection (RADD)	34
Stressed? Break-induced replication comes to the rescue!	34
The burden of overweight: Higher body mass index, but not vital exhaustion, is associated with higher DNA damage and lower DNA repair capacity	33
A novel Family V uracil DNA glycosylase from Sulfolobus islandicus REY15A	32
Corruption of DNA end-joining in mammalian chromosomes by progerin expression	32
WITHDRAWN: Melatonin increases doxorubicin-induced apoptosis via oxidative DNA damage in oral squamous cell carcinoma	30
Irc20 modulates LOH frequency and distribution in S. cerevisiae	30
Editorial Board	29
Editorial Board	28
Effect of mismatch repair on the mutational footprint of the bacterial SOS mutator activity	28
Editorial Board	28
Comparing Mfd- and UvrD-dependent models of transcription coupled DNA repair in live Escherichia coli using single-molecule tracking	28
Targeting base excision repair in precision oncology	26

PARP inhibitors in ovarian cancer: Mechanisms of resistance and implications to therapy	26
Positioning loss of PARP1 activity as the central toxic event in BRCA-deficient cancer	25
rumAB genes from SXT/R391 ICEs confer UV-induced mutability to Proteus mirabilis hosts and improve conjugation after UV irradiation	24
Chromatin meets the cytoskeleton: the importance of nuclear actin dynamics and associated motors for genome stability	24
Replication initiation: Implications in genome integrity	24
DNA repair-related heritable photosensitivity syndromes: Mutation landscape in a multiethnic cohort of 17 multigenerational families with high degree of consanguinity	21
PARP1-PROTACs providing novel opportunities in precision oncology by targeting DNA damage response	21
DNA synthesis across DNA hairpins by human PrimPol	21
Editorial Board	21
The role of SLFN11 in DNA replication stress response and its implications for the Fanconi anemia pathway	21
What are the DNA lesions underlying formaldehyde toxicity?	21
Double-strand break repair and mis-repair in 3D	20
RETRACTED: Thymoquinone sensitizes human hepatocarcinoma cells to TRAIL-induced apoptosis via oxidative DNA damage	20
The interferon response at the intersection of genome integrity and innate immunity	19
Metazoan nuclear pore complexes in gene regulation and genome stability	19
Strand discrimination in DNA mismatch repair	19
The differential roles of rad9 alternatively spliced forms in double- strand DNA break repair during Drosophila meiosis	19
Transcription-coupled nucleotide excision repair: New insights revealed by genomic approaches	18
Protein-protein interactions in the core nucleotide excision repair pathway	18
NBS1 binds directly to TOPBP1 via disparate interactions between the NBS1 BRCT1 domain and the TOPBP1 BRCT1 and BRCT2 domains	18
The dark side of homology-directed repair	18
ADP-ribosylation of DNA and RNA	18
Phospho-SIM and exon8b of PML protein regulate formation of doxorubicin-induced rDNA-PML compartment	18
Camptothecin compromises transcription recovery and cell survival against cisplatin and ultraviolet irradiation regardless of transcription-coupled nucleotide excision repair	17
Mutagenic repair of a ZFN-induced double-strand break in yeast: Effects of cleavage site sequence and spacer size	17
Damage-Net: A program for DNA repair meta-analysis identifies a network of novel repair genes that facilitate cancer evolution	17
Expression of BRCA1, BRCA2, RAD51, and other DSB repair factors is regulated by CRL4WDR70	16
XPA is susceptible to proteolytic cleavage by cathepsin L during lysis of quiescent cells	16
Long-range PCR as a tool for evaluating mitochondrial DNA damage: Principles, benefits, and limitations of the technique	16
Loss of alkyladenine DNA glycosylase alters gene expression in the developing mouse brain and leads to reduced anxiety and improved memory	16
Editorial Board	16
The multifaceted roles of the Ctf4 replisome hub in the maintenance of genome integrity	15
Recent advances in γH2AX biomarker-based genotoxicity assays: A marker of DNA damage and repair	15
Large dataset of octocoral mitochondrial genomes provides new insights into mt-mutS evolution and function	15
One-ended and two-ended breaks at nickase-broken replication forks	15
Endogenous base damage as a driver of genomic instability in homologous recombination-deficient cancers	15
Variation in G-quadruplex sequence and topology differentially impacts human DNA polymerase fidelity	15
Chromosomal single-strand break repair and neurological disease: Implications on transcription and emerging genomic tools	15
Centromere: A Trojan horse for genome stability	15
Sequence context effects of replication of Fapy•dG in three mutational hot spot sequences of the p53 gene in human cells	15
Biochemical characterization and mutational analysis of a mismatch glycosylase from the hyperthermophilic euryarchaeon Thermococcus barophilus Ch5	14
Cutting Edge Perspectives in genome maintenance X	14
Yearly perspective from the Co-Editors in Chief	14
Increased contribution of DNA polymerase delta to the leading strand replication in yeast with an impaired CMG helicase complex	13
TOPBP1 regulates resistance of gastric cancer to oxaliplatin by promoting transcription of PARP1	13
DNA polymerase delta Exo domain stabilizes mononucleotide microsatellites in human cells	13
Impairment of the non-catalytic subunit Dpb2 of DNA Pol ɛ results in increased involvement of Pol δ on the leading strand	13
The life and legacy of Sam Wilson (1939–2021)	13
miR-185–5p rewires cisplatin resistance by restoring miR-203a-3p expression via downregulation of SOX9	13
DNA glycosylase deficiency leads to decreased severity of lupus in the Polb-Y265C mouse model	13

miR-197-5p increases Doxorubicin-mediated anticancer cytotoxicity of HT1080 fibrosarcoma cells by decreasing drug efflux	13
Somatic mutation patterns at Ig and Non-Ig Loci	13
Inhibition of human DNA alkylation damage repair enzyme ALKBH2 by HIV protease inhibitor ritonavir	13
BRCA1 and BRCA2 in DNA damage and replication stress response: Insights into their functions, mechanisms, and implications for cancer treatment	12
Reversible association of ubiquitin with PCNA is important for template switching in S. cerevisiae	12
PARP1: Structural insights and pharmacological targets for inhibition	12
Weaponizing CRISPR/Cas9 for selective elimination of cells with an aberrant genome	12
Frailty, sex, and poverty are associated with DNA damage and repair in frail, middle-aged urban adults	12
Corrigendum to “Role of NEIL1 in genome maintenance” [DNA Repair 148 (2025) 103820]	12
MicroRNAs and the DNA damage response: How is cell fate determined?	12
Small-molecule activator of SMUG1 enhances repair of pyrimidine lesions in DNA	11
Editorial Board	11
C-terminal residues of DNA polymerase β and E3 ligase required for ubiquitin-linked proteolysis of oxidative DNA-protein crosslinks	11
Editorial Board	11
The flap endonuclease-1 mediated maturation of Okazaki fragments is critical for the cellular tolerance to remdesivir	11
Contents of previous 3 special issues in this series of perspectives	11
Oncometabolite 2-hydroxyglutarate suppresses basal protein levels of DNA polymerase beta that enhances alkylating agent and PARG inhibition induced cytotoxicity	10
CometChip enables parallel analysis of multiple DNA repair activities	10
Presenilin-1, mutated in familial Alzheimer’s disease, maintains genome stability via a γ-secretase dependent way	10
Genetic polymorphisms in DNA repair genes and hepatocellular carcinoma risk	10
Mechanisms and regulation of replication fork reversal	10
A moving target for drug discovery: Structure activity relationship and many genome (de)stabilizing functions of the RAD52 protein	10
Impact of DNA sequences on DNA ‘opening’ by the Rad4/XPC nucleotide excision repair complex	10
RNF4 prevents genomic instability caused by chronic DNA under-replication	10
Positive and negative regulators of RAD51/DMC1 in homologous recombination and DNA replication	9
Obituary	9
TFIIH central activity in nucleotide excision repair to prevent disease	9
Therapeutic targeting of mismatch repair proteins in triplet repeat expansion diseases	9
USP1 in regulation of DNA repair pathways	9
Phosphorylation-dependent assembly of DNA damage response systems and the central roles of TOPBP1	9
Processes shaping cancer genomes – From mitotic defects to chromosomal rearrangements	9
Determination of DNA lesion bypass using a ChIP-based assay	9
KBM-mediated interactions with KU80 promote cellular resistance to DNA replication stress in CHO cells	9
Incorporation of 5’,8-cyclo-2’deoxyadenosines by DNA repair polymerases via base excision repair	9
Probing the structure and function of polymerase θ helicase-like domain	9
Multi-omic analysis of altered transcriptome and epigenetic signatures in the UV-induced DNA damage response	9
Remdesivir triphosphate is a valid substrate to initiate synthesis of DNA primers by human PrimPol	9
Regulation of DNA damage-induced HLA class I presentation	9
Editorial Board	8
Screening of glycosylase activity on oxidative derivatives of methylcytosine: Pedobacter heparinus SMUG2 as a formylcytosine- and carboxylcytosine-DNA glycosylase	8
Pold4 subunit of replicative polymerase δ promotes fork slowing at broken templates	8
The mRNA tether model for activation-induced deaminase and its relevance for Ig somatic hypermutation and class switch recombination	8
Corrigendum to “Quantitative assessment of HR and NHEJ activities via CRISPR/Cas9-induced oligodeoxynucleotide-mediated DSB repair” [DNA Repair 70 (2018) 67–71]	8
Mlh1 interacts with both Msh2 and Msh6 for recruitment during mismatch repair	8
Phylogenetic distribution, structural analysis and interaction of nucleotide excision repair proteins in cyanobacteria	8
DNA lesions that block transcription induce the death of Trypanosoma cruzi via ATR activation, which is dependent on the presence of R-loops	8