OOIR: Observatory of International Research

Papers

(The TQCC of Current Neuropharmacology is 12. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-09-01 to 2025-09-01.)

Article	Citations
Mimicking Extracellular Matrix via Engineered Nanostructured Biomaterials for Neural Repair	136
Role of Glycerophospholipid Metabolism in Epilepsy	114
Effects of β -caryophyllene, A Dietary Cannabinoid, in Animal Models of Drug Addiction	113
Effect of Repetitive Transcranial Magnetic Stimulation in Inducing Weight Loss in Patients with Chronic Schizophrenia: A Randomized, Double-Blind Controlled 4-Week Study	98
Childhood Trauma and Self-harm in Youths with Bipolar Disorders	97
Comorbidities in Youth with Bipolar Disorder: Clinical Features and Pharmacological Management	81
Advances in the Pharmacological and Non-pharmacological Management of Non-motor Symptoms in Parkinson’s Disease: An Update Since 2017	80
Local and Remote Chemogenetic Suppression of Hippocampal Seizures in Rats	78
Redox Modulation of Meniere Disease by Coriolus versicolor Treatment, a Nutritional Mushroom Approach with Neuroprotective Potential	77
Early Family Intervention for Youth at Risk for Bipolar Disorder: Psychosocial and Neural Mediators of Outcome	71
Long-Term Implicit Epigenetic Stress Information in the Enteric Nervous System and its Contribution to Developing and Perpetuating IBS	70
The Effects of Drugs used for the Treatment of Attention Deficit Hyperactivity Disorder (ADHD) on Pregnancy Outcome and Breast-feeding: A Critical Review	69
Neuroprotective Role of Quercetin against Alpha-Synuclein-Associated Hallmarks in Parkinson’s Disease	61
Modulating Ferroptosis: A Novel Approach to Promote Neural Repair in Brain Injury	60
The Role of Natural Products in Treatment of Depressive Disorder	59
Three Decades of Valproate: A Current Model for Studying Autism Spectrum Disorder	57
Neurocognitive Correlates of Cerebellar Volumetric Alterations in Youth with Pediatric Bipolar Spectrum Disorders and Bipolar Offspring	56
siRNA Therapeutics: Future Promise for Neurodegenerative Diseases	49
Meet the Editorial Board Member	46
Sex-Specific Association between Antioxidant Defense System and Therapeutic Response to Risperidone in Schizophrenia: A Prospective Longitudinal Study	46
Thematic Selection: Stress and Stress-related Disorders Neurobiology & Translational Aspects of Stress-related Disorders (Part 3)	46
Antiseizure Medications: Advancements, Challenges, and Prospects in Drug Development	45
Exploring Mechanistic Insights by Carotenoids in Neuropathic and Inflammatory Pain	45
The Mechanisms and Application Prospects of Astrocyte Reprogramming into Neurons in Central Nervous System Diseases	43
The Formyl Peptide Receptor 2 as a Target for Promotion of Resolution of Inflammation	42

Myeloid-derived Suppressor Cells and Multiple Sclerosis	41
Adherence to, and Persistence of, Antidepressant Therapy in Patients with Major Depressive Disorder: Results from a Population-based Study in Italy	39
Unveiling the Potential Neuroprotective Effect of Bioactive Compounds from Plants with Sedative and Mood-Modulating Properties: Innovative Approaches for the Prevention of Alzheimer's and Parkinson's	39
Pharmacological Strategies for Bipolar Disorders in Acute Phases and Chronic Management with a Special Focus on Lithium, Valproic Acid, and Atypical Antipsychotics	38
Deciphering the Causality between Gut Microbiota Dysbiosis and Poisoning by Narcotics and Psychodysleptics: A Mendelian Randomization Analysis	38
Perspective on the Relationship between GABAA Receptor Activity and the Apparent Potency of an Inhibitor	37
What is the Role of Lithium in Epilepsy?	37
Nabiximols is Efficient as Add-On Treatment for Patients with Multiple Sclerosis Spasticity Refractory to Standard Treatment: A Systematic Review and Meta-Analysis of Randomised Clinical Trials	36
Antioxidants, Hormetic Nutrition, and Autism	35
Effects of Deep Brain Stimulation on Sleep-Wake Disturbances in Patients with Parkinson's Disease: A Narrative Review	34
Progression in Moyamoya Disease: Clinical Features, Neuroimaging Evaluation, and Treatment	34
Long-term Efficacy and Safety of Sodium Oxybate in Treating Alcohol Use Disorder: A Systematic Review and Meta-Analysis	33
OL-FS13 Alleviates Cerebral Ischemia-reperfusion Injury by Inhibiting miR-21-3p Expression	33
Meet the Country Editor	33
mGlu3 Metabotropic Glutamate Receptors as a Target for the Treatment of Absence Epilepsy: Preclinical and Human Genetics Data	33
Linking Diabetes to Alzheimer’s Disease: Potential Roles of Glucose Metabolism and Alpha-Glucosidase	33
Fast Declining Prediction in Alzheimer’s Disease from Early Clinical Assessment	32
Corrigendum to: “Effects of Alcohol on EEG Activity: A Systematic Review Focused on Sex-Related Differences in Youth”	32
Meet the Editorial Board Member	32
Early Enteral Feeding Restores Neurofilament Light Chain Serum Levels in Preterm Newborns	31
The Emerging Role of Quercetin in the Treatment of Chronic Pain	30
How to Optimize the Effectiveness and Safety of Parkinson’s Disease Therapy? – A Systematic Review of Drugs Interactions with Food and Dietary Supplements	30
Daridorexant and Insomnia in Clinical Practice: A Nominal Group Technique Consensus Study among Italian Sleep and Insomnia Experts	30
Is Antipsychotic Drug Use During Pregnancy Associated with Increased Malformation Rates and Worsening of Maternal and Infant Outcomes? A Systematic Review	30
Vortioxetine versus SSRI/SNRI with Pregabalin Augmentation in Treatment-Resistant Burning Mouth Syndrome: A Prospective Clinical Trial	30
New Insights of Early Brain Injury after Subarachnoid Hemorrhage: A Focus on the Caspase Family	29
Paraquat and Parkinson’s Disease: The Molecular Crosstalk of Upstream Signal Transduction Pathways Leading to Apoptosis	29
Neuroinflammatory Signaling in the Pathogenesis of Alzheimer’s Disease	29
Diabetes, Alzheimer's Disease Risk Factors, and the Cafeteria Diet: A Comprehensive Review	28
The Lymphatic System In The Brain Clearance Mechanisms - New Therapeutic Perspectives For Alzheimer's Disease	28
Role of Microglia in Psychostimulant Addiction	28
The Role of the Microbiota-Gut-Brain Axis in Perinatal Depression: Novel Insights for Treatment	28
Gut Microbiome in Alzheimer’s Disease: from Mice to Humans	27
Toxic Effects of Methamphetamine on Perivascular Health: Co-morbid Effects of Stress and Alcohol Use Disorders	27
Major Depression in Comorbidity with Substance use Disorders: Patients’ Features and Clinical-Neurobiological Rationale of Antidepressant Treatments	27
Meet the Editorial Board Member	27
Drug Target to Alleviate Mitochondrial Dysfunctions in Alzheimer’s Disease: Recent Advances and Therapeutic Implications	26
A Review on Preclinical Models of Ischemic Stroke: Insights Into the Pathomechanisms and New Treatment Strategies	26
The Role of Epigenetics in the Pathogenesis and Potential Treatment of Attention Deficit Hyperactivity Disorder	26
Targeting Gut Dysbiosis and Microbiome Metabolites for the Development of Therapeutic Modalities for Neurological Disorders	26
Alzheimer's Disease May Benefit from Olive Oil Polyphenols: A Systematic Review on Preclinical Evidence Supporting the Effect of Oleocanthal on Amyloid-β Load	25
Pathomechanistic Networks of Motor System Injury in Amyotrophic Lateral Sclerosis	25
Hydroxychloroquine Prevents High-altitude Cerebral Edema by Inhibiting Endothelial Claudin-5 Autophagic Degradation	25
The Role of Induced Pluripotent Stem Cells in the Treatment of Stroke	25
Insights Into the Role of Copper in Neurodegenerative Diseases and the Therapeutic Potential of Natural Compounds	24
New Insights on Mechanisms and Therapeutic Targets of Cerebral Edema	24
Depression and the Glutamate/GABA-Glutamine Cycle	24
Depression: An Insight into Heterocyclic and Cyclic Hydrocarbon Compounds Inspired from Natural Sources	24
Serine Proteases and Chemokines in Neurotrauma: New Targets for Immune Modulating Therapeutics in Spinal Cord Injury	24
Dapsone, More than an Effective Neuro and Cytoprotective Drug	24

Meet the Section Editor	23
Neuroinflammation: The Role of Anthocyanins as Neuroprotectants	23
Aryl Hydrocarbon Receptor Establishes a Delicate Balance between the Level of the Trace Amine Tryptamine and Monoamine Oxidase Activity in the Brain and Periphery in Health and Conditions such as Neur	23
Spatiomolecular Characterization of Dopamine D2 Receptors Cells in the Mouse External Globus Pallidus	23
Sensory Reinforced Corticostriatal Plasticity	22
From Phenomes to Genes: Phenotype-based Strategies in Rodents for Research on the Neurobiological and Genetic Bases of Psychiatric-relevant Traits	22
Effects of Natural Products on Neuromuscular Junction	22
The Modulatory Effects of Anesthetics and Analgesics on Neurophysiological Monitoring and Underlying Mechanisms	22
Machine Learning and Pharmacogenomics at the Time of Precision Psychiatry	21
Early Efficacy of Antipsychotic Medications at Week 2 Predicts Subsequent Responses at Week 6 in a Large-scale Randomized Controlled Trial	21
Emerging Roles of Microglia in Blood-Brain Barrier Integrity in Aging and Neurodegeneration	21
Targeting Estrogen Signaling in the Radiation-induced Neurodegeneration: A Possible Role of Phytoestrogens	21
MiR-142-3p is a Critical Modulator of TNF-mediated Neuronal Toxicity in Multiple Sclerosis	21
Association between Suicidal Ideation and Immune Parameters in Firstepisode Patients with Schizophrenia	21
Virtual Screening-Based Drug Development for the Treatment of Nervous System Diseases	21
Titration of Pharmacological Responses in ICU Patients by Quantified EEG	21
The Dual Role of Microglia in Multiple Sclerosis and its Implications for Diagnostics and Repair	20
Prospective Investigation of Glutamate Levels and Percentage Gray Matter in the Medial Prefrontal Cortex in Females at Risk for Postpartum Depression	20
Advances in the Therapeutic Use of Non-Ergot Dopamine Agonists in the Treatment of Motor and Non-Motor Symptoms of Parkinson’s Disease	20
Bibliometric Analysis of Antipsychotic-induced Metabolic Disorder from 2006 to 2021 Based on WoSCC Database	20
Bibliometric Analysis of the Research Status and Global Trends in Behavioral and Psychological Symptoms of Dementia in Alzheimer’s Disease from 2002 to 2022	20
Neonatal Arterial Ischaemic Stroke: Advances in Pathologic Neural Death, Diagnosis, Treatment, and Prognosis	20
Structural and Functional MRI Brain Changes in Patients with Schizophrenia Following Electroconvulsive Therapy: A Systematic Review	20
The Potential Role of Glutamate Receptors and their Antagonists or Modulators in Migraine Therapy	20
Current Insights into the Neurotoxicity of Melamine: A Comprehensive Review	20
The Role of Caspase Family in Acute Brain Injury: The Potential Therapeutic Targets in the Future	20
The Potential Influence of Associated Antidepressants on the Pharmacokinetic Profile of Esketamine in Patients Affected by Treatment-resistant Depression	19
Receptors for Advanced Glycation End Products (RAGE): Promising Targets Aiming at the Treatment of Neurodegenerative Conditions	19
Neuroprotective Potential of Caffeic Acid Phenethyl Ester (CAPE) in CNS Disorders: Mechanistic and Therapeutic Insights	19
Modulating Gut Microbiota: An Emerging Approach in the Prevention and Treatment of Multiple Sclerosis	19
Essential Oils in Experimental Models of Neuropsychiatric Disorders: A Systematic Review	19
Isolated Mitochondrial Preparations andIn organelloAssays: A Powerful and RelevantEx vivoTool for Assessment of Brain (Patho)physiology	18
Meet the Editorial Board Member	18
Conventional and Emerging Drug Targeting Sites in Alzheimer’s Disease and the Role of Translational Informatics in its Diagnosis and Management	18
Sensorimotor Alterations Induced by Novel Fentanyl Analogs in Mice: Possible Impact on Human Driving Performances	18
Biomaterials for Neurotherapeutics: From Lab Discovery to Clinical Application	18
Resilience and Recalibration of Bibliometric Indicators in Neurosciences and Neuropharmacology Journals After COVID-19: A Longitudinal Rate of Change Analysis Using Mixed-Effects Models	18
Development of Non-opioid Analgesics Targeting Two-pore Domain Potassium Channels	18
A New Augmentation Strategy against Depression Combining SSRIs and the N-terminal Fragment of Galanin (1-15)	18
An Update on Nondopaminergic Treatments for Motor and Non-motor Symptoms of Parkinson’s Disease	18
Restoring Brain Pathways Involved in Diabetes-Associated Neurocognitive Disorders: The Potential of Dipeptidyl Peptidase 4 Inhibitors as a Therapeutic Strategy	18
Intercellular Communication Pathways in Cerebral Ischemia: Mechanisms, Molecular Insights, and Therapeutic Implications	18
Modulation of in vitro Network Activity by Optogenetic Stimulation of Parvalbumin-positive Interneurons During Estrous Cycle	17
The Dorsolateral Prefrontal Cortex: A High-level Hub for Allostatic Cardiovascular Control	17
Interleukin-17A in Alzheimer’s Disease: Recent Advances and Controversies	17
Advances on Epigenetic Drugs for Pediatric Brain Tumors	17
Secondary White Matter Injury Mediated by Neuroinflammation after Intracerebral Hemorrhage and Promising Therapeutic Strategies of Targeting the NLRP3 Inflammasome	17
Early-Life Microbiome and Neurodevelopmental Disorders: A Systematic Review and Meta-Analysis	17
Fabry Disease: Current and Novel Therapeutic Strategies. A Narrative Review	17
The Role of Total White Blood Cell Count in Antipsychotic Treatment for Patients with Schizophrenia	17
The Comprehensive Neural Mechanism of Oxytocin in Analgesia	17
Association of Oxidative Stress with Neurological Disorders	17
UFMylation: A Potential Modification for Neurological Diseases	17
7,8-Dihydroxyflavone and Neuropsychiatric Disorders: A Translational Perspective from the Mechanism to Drug Development	17
Cariprazine Augmentation in Treatment-Resistant Bipolar Depression: Data from a Retrospective Observational Study	17
Targeting the Main Sources of Reactive Oxygen Species Production: Possible Therapeutic Implications in Chronic Pain	17
Pharmacological and Non-pharmacological Treatments of Sleep Disorders in Parkinson's Disease	17
Natural Products-based Drugs: Potential Drug Targets Against Neurological Degeneration	16
Challenges of Delirium Management in Patients with Traumatic Brain Injury: From Pathophysiology to Clinical Practice	16
Non-canonical Molecular Targets for Novel Analgesics: Intracellular Calcium and HCN Channels	16
Unveiling the Potential of Polyphenols as Anti-Amyloid Molecules in Alzheimer’s Disease	16
Acknowledgements to Reviewers	16
Contributions of Zebrafish Studies to the Behavioural Consequences of Early Alcohol Exposure: A Systematic Review	16
The Diverse Network of Brain Histamine in Feeding: Dissect its Functions in a Circuit-Specific Way	16
Cholesterol in Brain Development and Perinatal Brain Injury: More than a Building Block	16
Vasoactive Intestinal Peptide: A Neuropeptide that Plays an Important Role in Parkinson's Disease	15
Sleep Disturbance, Irritability, and Response to Lurasidone Treatment in Children and Adolescents with Bipolar Depression	15
Pathways from the Superior Colliculus to the Basal Ganglia	15
Potential of Medicinal Plants as Neuroprotective and Therapeutic Properties Against Amyloid-β-Related Toxicity, and Glutamate-Induced Excitotoxicity in Human Neural Cells	15
Determining the Interaction in a Drug Combination using the Dose-based or Effect-based Method	15
How to Modulate Peripheral and Central Nervous System to Treat Acute Postoperative Pain and Prevent Pain Persistence	15
Exploring the Effectiveness and Potential Pharmacological Mechanism of Minocycline for Spinal Cord Injury through Meta-Analysis and Network Pharmacology	15
Epigenetics of Fear, Anxiety and Stress – Focus on Histone Modifications	15
Abusive use of Zolpidem as a Result of COVID-19 and Perspectives of Continuity of the Problem in the Post-Pandemic Period	15
Does the Brain Matter? Cortical Alterations in Pediatric Bipolar Disorder: A Critical Review of Structural and Functional Magnetic Resonance Studies	15
A Bibliometric and Visual Analysis of Single Nucleotide Polymorphism Studies in Depression	15
The Fragile Balance: Autophagy's Role in Neurodegenerative Disease Progression	15
MicroRNAs as Potential Biomarkers and Therapeutic Targets in Ischemic Stroke from the Perspective of Inflammation	15
Mediterranean Pattern Diet in Multiple Sclerosis: A Review Focusing on Immunometabolites	15
Therapeutic Approaches Interfering with Nuclear Localization Signals: An Emerging Strategy for CNS-Related Diseases	14

Striatal Acetylcholine and Dopamine Interactions Produce Situationappropriate Action Selection	14
Emerging Neurobiological Concepts and Therapies for Neurological Rare Diseases	14
Meet the Section Editor	14
Galectin-3 in Microglia-Mediated Neuroinflammation: Implications for Central Nervous System Diseases	14
Patients Stratification Strategies to Optimize the Effectiveness of Scavenging Biogenic Aldehydes: Towards a Neuroprotective Approach for Parkinson's Disease	14
Meet the Country Editor	14
Preface	14
Beyond its Psychiatric Use: The Benefits of Low-dose Lithium Supplementation	14
Central Sensitization and Pain: Pathophysiologic and Clinical Insights	14
Drugs Used in the Treatment of Multiple Sclerosis During COVID-19 Pandemic: A Critical Viewpoint	14
Contribution of Drugs to Drowning in Scotland from 1996 to 2020	13
Neural Networks of Knowledge: Ontologies Pioneering Precision Medicine In Neurodegenerative Diseases	13
Therapeutic Potential of Anesthesiology for Sleep Disorders in the Perioperative Period	13
Baseline Plasma BDNF Levelsare Associated with Antianhedonic Effects of Repeated-Dose Intravenous Ketamine in Major Depressive Disorder	13
The Natural Protoalkaloid Methyl-2-Amino-3-Methoxybenzoate (MAM) Alleviates Positive as well as Cognitive Symptoms in Rat and Mouse Schizophrenia Models	13
Epilepsy and Cognitive Impairment in Childhood and Adolescence: A Mini-Review	13
Antidepressant Prescription for Major Depressive Disorder: Results from a Population-Based Study in Italy	13
Differing Prevalence and Correlates of Metabolic Syndromes Between Chlorpromazine and Clozapine: A 10-year Retrospective Study of a Male Chinese Cohort	13
Neurobehavioral Profiles of Six Genetically-based Rat Models of Schizophrenia- related Symptoms	13
Real-World Effectiveness of Cladribine for Patients with Multiple Sclerosis: A Sicilian Multicentric Experience (Rewind Study)	13
Crosstalk Between Covid-19 and Associated Neurological Disorders: A Review	13
Epigenetic Mechanisms in the Pathophysiology and Progression of Epilepsy: A Comprehensive Review of Experimental and Clinical Studies	13
Acid-Sensing Ion Channels: Focus on Physiological and Some Pathological Roles in the Brain	13
Powering Up the Brain: Intercellular Mitochondrial Quality Control and Its Implication in Stroke	13
A Prospective Clinical Trial of Efgartigimod for New-Onset Generalized Myasthenia Gravis	13
Rethinking ‘Innovation’ in Psychiatry with Older and Newer Treatments: From Bench to Benchside	12
Bipolar Disorder and Manic-Like Symptoms in Alzheimer’s, Vascular and Frontotemporal Dementia: A Systematic Review	12
Update on Cannabidiol Clinical Toxicity and Adverse Effects: A Systematic Review	12
Novel Synthetic and Natural Therapies for Traumatic Brain Injury	12
Anticholinesterases Traits Inbuilt in Buxaceae Plant Extracts against Alzheimer’s Disease	12
Two Distinct Neuronal Populations in the Rat Parafascicular Nucleus Oppositely Encode the Engagement in Stimulus-driven Reward-seeking	12
The Orexin System: A Potential Player in the Pathophysiology of Absence Epilepsy	12
Neutrophil Heterogeneity and its Roles in the Inflammatory Network after Ischemic Stroke	12
Potential Benefits of Quercetin through P2X7 Modulation against Neuroinflammation in Alzheimer's Disease	12
Protective Role of Electroacupuncture Against Cognitive Impairment in Neurological Diseases	12
Symptoms of Protracted Alcohol Withdrawal in Patients with Alcohol Use Disorder: A Comprehensive Systematic Review	12
Epilepsy and Related Neuropsychiatric Comorbidities: Basic and Clinical Research	12
Extracellular Vesicles, Stem Cells and the Role of miRNAs in Neurodegeneration	12
Immune System and Methamphetamine: Molecular Basis of a Relationship	12
Glucocorticosteroids Effects on Brain Development in the Preterm Infant: A Role for Microglia?	12
Clinical Trials of Non-Coding RNAs as Diagnostic and Therapeutic Biomarkers for Central Nervous System Injuries	12
Olanzapine-Induced Weight Gain and Glycolipid Metabolism Aberrations in First-Episode and Antipsychotic-Naïve Schizophrenia Patients: A Longitudinal Study	12
Microtubule-modulating Agents in the Fight Against Neurodegeneration: Will it ever Work?	12
The Use of Zebrafish as a Non-traditional Model Organism in Translational Pain Research: The Knowns and the Unknowns	12
Promising Perspective to Facioscapulohumeral Muscular Dystrophy Treatment: Nutraceuticals and Phytochemicals	12