Current Neuropharmacology

Article	Citations
Recent Advancements in Pathogenesis, Diagnostics and Treatment of Alzheimer’s Disease	252
Role of Nuclear Factor Kappa B (NF-κB) Signalling in Neurodegenerative Diseases: An Mechanistic Approach	127
Crosstalk between Inflammation and the BBB in Stroke	77
Angiogenesis and Blood-Brain Barrier Permeability in Vascular Remodeling after Stroke	67
Molecular Hybridization as a Tool in the Design of Multi-target Directed Drug Candidates for Neurodegenerative Diseases	66
Understanding the Role of Histone Deacetylase and their Inhibitors in Neurodegenerative Disorders: Current Targets and Future Perspective	61
A Scientometrics Analysis and Visualization of Depressive Disorder	59
Ultramicronized Palmitoylethanolamide and Luteolin Supplement Combined with Olfactory Training to Treat Post-COVID-19 Olfactory Impairment: A Multi-Center Double-Blinded Randomized Placebo- Controlled	51
Alzheimer’s Disorder: Epigenetic Connection and Associated Risk Factors	51
Role of Nitric Oxide in Neurodegeneration: Function, Regulation, and Inhibition	49
‘New/Designer Benzodiazepines’: An Analysis of the Literature and Psychonauts’ Trip Reports	47
Effects of Withania somnifera (Ashwagandha) on Stress and the Stress- Related Neuropsychiatric Disorders Anxiety, Depression, and Insomnia	47
The Potential Role of Dysfunctions in Neuron-Microglia Communication in the Pathogenesis of Brain Disorders	46
The Dual Role of Microglia in Blood-Brain Barrier Dysfunction after Stroke	45
Selenium and Neurological Diseases: Focus on Peripheral Pain and TRP Channels	44
Role of Oxidative Stress and Metal Toxicity in the Progression of Alzheimer’s Disease	42
Temozolomide: An Updated Overview of Resistance Mechanisms, Nanotechnology Advances and Clinical Applications	42
The Multifaceted Therapeutic Role of N-Acetylcysteine (NAC) in Disorders Characterized by Oxidative Stress	41
The Stroke-Induced Blood-Brain Barrier Disruption: Current Progress of Inspection Technique, Mechanism, and Therapeutic Target	38
Mitochondrion as a Selective Target for the Treatment of Atherosclerosis: Role of Mitochondrial DNA Mutations and Defective Mitophagy in the Pathogenesis of Atherosclerosis and Chronic Inflammation	38
PTSD in the COVID-19 Era	36
Exosomes as a Promising Therapeutic Strategy for Peripheral Nerve Injury	36
The Critical Period for Neuroprotection by Estrogen Replacement Therapy and the Potential Underlying Mechanisms	34
Potential Mechanisms and Clinical Effectiveness of Acupuncture in Depression	33
Neuroprotective Polyphenols: A Modulatory Action on Neurotransmitter Pathways	32

Pre-clinical to Clinical Translational Failures and Current Status of Clinical Trials in Stroke Therapy: A Brief Review	32
5-HT3 Receptor Antagonism: A Potential Therapeutic Approach for the Treatment of Depression and other Disorders	31
The Role of Autophagy in the Pathogenesis of Ischemic Stroke	31
Mitochondrial Dysfunction in Alzheimer’s Disease: Opportunities for Drug Development	31
A New Vision of Mitochondrial Unfolded Protein Response to the Sirtuin Family	31
Neuroinflammatory Signaling in the Pathogenesis of Alzheimer’s Disease	30
Glia-Driven Neuroinflammation and Systemic Inflammation in Alzheimer’s Disease	30
Dysregulation of the Gut-Brain Axis, Dysbiosis and Influence of Numerous Factors on Gut Microbiota Associated Parkinson’s Disease	30
Underlying Mechanisms and Potential Therapeutic Molecular Targets in Blood-Brain Barrier Disruption after Subarachnoid Hemorrhage	29
Recent Evidence in Epigenomics and Proteomics Biomarkers for Early and Minimally Invasive Diagnosis of Alzheimer’s and Parkinson’s Diseases	28
Neuroinflammation in Huntington’s Disease: A Starring Role for Astrocyte and Microglia	28
C-Phycocyanin-derived Phycocyanobilin as a Potential Nutraceutical Approach for Major Neurodegenerative Disorders and COVID-19- induced Damage to the Nervous System	28
The Effects of General Anesthetics on Synaptic Transmission	28
Depression and Pain: Use of Antidepressants	28
Off-label Uses of Selective Serotonin Reuptake Inhibitors (SSRIs)	27
The Role of Mitochondrial Impairment in Alzheimer´s Disease Neurodegeneration: The Tau Connection	27
Management Perspective of Wilson’s Disease: Early Diagnosis and Individualized Therapy	27
Selective Serotonin Reuptake Inhibitors (SSRIs) and Serotonin Norepinephrine Reuptake Inhibitors (SNRIs) During Pregnancy and the Risk for Autism spectrum disorder (ASD) and Attention deficit hyperact	26
Targeting S100B Protein as a Surrogate Biomarker and its Role in Various Neurological Disorders	26
Therapeutic and Mechanistic Effects of Curcumin in Huntington’s Disease	25
New Mechanisms and Targets of Subarachnoid Hemorrhage: A Focus on Mitochondria	25
Traumatic Brain Injury: A Forensic Approach: A Literature Review	24
Tetrahydrobioterin (BH4) Pathway: From Metabolism to Neuropsychiatry	23
The Links between Cardiovascular Diseases and Alzheimer's Disease	23
cGAS-STING-mediated IFN-I Response in Host Defense and Neuroinflammatory Diseases	23
An Overview on Chemotherapy-induced Cognitive Impairment and Potential Role of Antidepressants	22
Acid-Sensing Ion Channels: Focus on Physiological and Some Pathological Roles in the Brain	22
Current and Future Neuropharmacological Options for the Treatment of Essential Tremor	22
Inhibition of Caspase 3 and Caspase 9 Mediated Apoptosis: A Multimodal Therapeutic Target in Traumatic Brain Injury	21
Endocannabinoid Receptors in the CNS: Potential Drug Targets for the Prevention and Treatment of Neurologic and Psychiatric Disorders	21
Neuropharmacological and Neurogenetic Correlates of Opioid Use Disorder (OUD) As a Function of Ethnicity: Relevance to Precision Addiction Medicine	21
Neurodegenerative Pathways in Alzheimer’s Disease: A Review	20
Pharmacological and Non-pharmacological Treatments of Sleep Disorders in Parkinson's Disease	20
Neural Substrates for the Regulation of Sleep and General Anesthesia	20
SIRT1 Promotes Neuronal Fortification in Neurodegenerative Diseases through Attenuation of Pathological Hallmarks and Enhancement of Cellular Lifespan	19
Current Understanding of Central Nervous System Drainage Systems: Implications in the Context of Neurodegenerative Diseases	19
Gut Microbiota Regulate Astrocytic Functions in the Brain: Possible Therapeutic Consequences	19
The Updated Role of the Blood Brain Barrier in Subarachnoid Hemorrhage: From Basic and Clinical Studies	19
Behavioral Tasks Evaluating Schizophrenia-like Symptoms in Animal Models: A Recent Update	19
Emerging Evidence for Neuropsycho-Consequences of COVID-19	19
Elucidating the Potential Side Effects of Current Anti-Seizure Drugs for Epilepsy	19
PLGA-Based Curcumin Delivery System: An Interesting Therapeutic Approach in the Treatment of Alzheimer’s Disease	18
Neuroprotective Effects of Neuropeptide Y against Neurodegenerative Disease	18
Role of Hydrogen Sulfide and Polysulfides in Neurological Diseases: Focus on Protein S-Persulfidation	18
Molecular Mechanism of Autophagy: Its Role in the Therapy of Alzheimer’s Disease	18
Treatment of Posttraumatic Stress Disorder: A State-of-the-art Review	18
Current Status of Drug Targets and Emerging Therapeutic Strategies in the Management of Alzheimer's Disease	18
Interaction between Zinc, GPR39, BDNF and Neuropeptides in Depression	18
Nanotechnological Advances for Nose to Brain Delivery of Therapeutics to Improve the Parkinson Therapy	17
The Ambiguous Role of Microglia in Aβ Toxicity: Chances for Therapeutic Intervention	17

Association of Oxidative Stress with Neurological Disorders	17
Sleep Disturbances and Cognitive Impairment in the Course of Type 2 Diabetes-A Possible Link	17
Tyrosol as a Neuroprotector: Strong Effects of a “Weak” Antioxidant	17
Circadian Rhythm Disruption and Alzheimer’s Disease: The Dynamics of a Vicious Cycle	17
From the Molecular Mechanism to Pre-clinical Results: Anti-epileptic Effects of Fingolimod	17
Effects of General Anesthetics on Synaptic Transmission and Plasticity	17
MicroRNAs in the Blood-Brain Barrier in Hypoxic-Ischemic Brain Injury	17
The Dawn of Mitophagy: What Do We Know by Now?	17
Anti-IL-6 Therapies for Neuromyelitis Optica Spectrum Disorders: A Systematic Review of Safety and Efficacy	16
Xenogeneic Decellularized Extracellular Matrix-based Biomaterials For Peripheral Nerve Repair and Regeneration	16
Autophagy & Phagocytosis in Neurological Disorders and their Possible Cross-talk	16
Targeting Brain-spleen Crosstalk After Stroke: New Insights Into Stroke Pathology and Treatment	16
Effects of Risperidone in Autistic Children and Young Adults: A Systematic Review and Meta-Analysis	16
A Comprehensive Review of Alzheimer’s Association with Related Proteins: Pathological Role and Therapeutic Significance	16
Synthetic Cannabinoids and Cathinones Cardiotoxicity: Facts and Perspectives	16
Recent Trends in the Management of Alzheimer’s Disease: Current Therapeutic Options and Drug Repurposing Approaches	16
Nerve Growth Factor in Alcohol Use Disorders	16
Neuroprotective Potential of Caffeic Acid Phenethyl Ester (CAPE) in CNS Disorders: Mechanistic and Therapeutic Insights	15
Chlorogenic Acid Improves PTSD-like Symptoms and Associated Mechanisms	15
Progression in Moyamoya Disease: Clinical Features, Neuroimaging Evaluation, and Treatment	15
Adolescent Substance Abuse, Transgenerational Consequences and Epigenetics	15
The e-Psychonauts’ ‘Spiced’ World; Assessment of the Synthetic Cannabinoids’ Information Available Online	15
Adult Neurogenesis in Epileptogenesis: An Update for Preclinical Finding and Potential Clinical Translation	15
Effects of Histone Modification in Major Depressive Disorder	15
Biomedical Perspectives of Acute and Chronic Neurological and Neuropsychiatric Sequelae of COVID-19	15
Src Family Kinases in the Central Nervous System: Their Emerging Role in Pathophysiology of Migraine and Neuropathic Pain	14
The Brain-gut Axis-where are we now and how can we Modulate these Connections?	14
Is It the Twilight of BACE1 Inhibitors?	14
Challenges of Delirium Management in Patients with Traumatic Brain Injury: From Pathophysiology to Clinical Practice	14
Therapeutic Potential of Multifunctional Derivatives of Cholinesterase Inhibitors	14
Drug Delivery Nanosystems in Glioblastoma Multiforme Treatment: Current State of the Art	14
Targeting Glioblastoma: The Current State of Different Therapeutic Approaches	14
Plant-Derived Natural Compounds for the Treatment of Amyotrophic Lateral Sclerosis: An Update	14
Ketogenic Diet: An Effective Treatment Approach for Neurodegenerative Diseases	14
Alzheimer’s Disease: New Concepts on the Role of Autoimmunity and NLRP3 Inflammasome in the Pathogenesis of the Disease	14
Role of Grina/Nmdara1 in the Central Nervous System Diseases	14
Use of Phenytoin, Phenobarbital Carbamazepine, Levetiracetam Lamotrigine and Valproate in Pregnancy and Breastfeeding: Risk of Major Malformations, Dose-dependency, Monotherapy vs Polytherapy, Pharmac	14
Expanding the Arsenal Against Huntington's Disease-Herbal Drugs and Their Nanoformulations	14
Linalool as a Therapeutic and Medicinal Tool in Depression Treatment: A Review	13
Effects of Di-2-Ethylhexyl Phthalate on Central Nervous System Functions: A Narrative Review	13
Repetitive Transcranial Magnetic Stimulation Combined with Antidepressants for the First Episode of Major Depressive Disorder	13
Phytocannabinoids: General Aspects and Pharmacological Potential in Neurodegenerative Diseases	13
A Healthy Gut for a Healthy Brain: Preclinical, Clinical and Regulatory Aspects	13
Novel Synthetic and Natural Therapies for Traumatic Brain Injury	13
Peripheral and Central Glutamate Dyshomeostasis in Neurodegenerative Disorders	13
Neurochemical and Behavioral Consequences of Ethanol and/or Caffeine Exposure: Effects in Zebrafish and Rodents	13
Immune Checkpoint Inhibitors and Neurotoxicity	13
Pharmacologic Treatment of Restless Legs Syndrome	13
The Emerging Role of the Double-Edged Impact of Arachidonic Acid- Derived Eicosanoids in the Neuroinflammatory Background of Depression.	13
BACE1: A Key Regulator in Alzheimer’s Disease Progression and Current Development of its Inhibitors	12
Protective Effects of Dendrobium nobile Lindl. Alkaloids on Alzheimer's Disease-like Symptoms Induced by High-methionine Diet	12
Crocus Sativus L. (Saffron) in Alzheimer’s Disease Treatment: Bioactive Effects on Cognitive Impairment	12
Potential Therapeutic Approaches to Alzheimer’s Disease By Bioinformatics, Cheminformatics And Predicted Adme-Tox Tools	12
Green Tea, A Medicinal Food with Promising Neurological Benefits	12
The Potential Role of Hypoxia-Inducible Factor-1 in the Progression and Therapy of Central Nervous System Diseases	12
Role of Gut Microbiota in Multiple Sclerosis and Potential Therapeutic Implications	12
Phytochemicals Targeting Oxidative Stress, Interconnected Neuroinflammatory, and Neuroapoptotic Pathways Following Radiation	12
Cholecystokinin-Mediated Neuromodulation of Anxiety and Schizophrenia: A “Dimmer-Switch” Hypothesis	12
The Complexity of Secondary Cascade Consequent to Traumatic Brain Injury: Pathobiology and Potential Treatments	12
Evaluation of Anti-inflammatory Nutraceuticals in LPS-induced Mouse Neuroinflammation Model: An Update	12
Current and Emerging Treatments for Methamphetamine Use Disorder	12
Hydrogen Sulfide (H2S) Signaling as a Protective Mechanism against Endogenous and Exogenous Neurotoxicants	12
Is Adult Hippocampal Neurogenesis Really Relevant for the Treatment of Psychiatric Disorders?	11
Presynaptic Release-regulating Metabotropic Glutamate Receptors: An Update	11
Melatonin and Melatonergic Influence on Neuronal Transcription Factors: Implications for the Development of Novel Therapies for Neurodegenerative Disorders	11
Antioxidant Enzymes and Weight Gain in Drug-naive First-episode Schizophrenia Patients Treated with Risperidone for 12 Weeks: A Prospective Longitudinal Study	11
The Role of Neuroglial Metabotropic Glutamate Receptors in Alzheimer’s Disease	11
Therapeutic Strategies to Protect the Central Nervous System against Shiga Toxin from Enterohemorrhagic Escherichia coli	11
Pathways Involved in Remyelination after Cerebral Ischemia	11
Effects of Mulberry on The Central Nervous System: A Literature Review	11
Beyond its Psychiatric Use: The Benefits of Low-dose Lithium Supplementation	11
Modulation of Gut-Brain Axis by Probiotics: A Promising Anti-depressant Approach	11
The Investigation into Neurotoxicity Mechanisms of Nonylphenol: A Narrative Review	10
Crosstalk between Microglia and Neurons in Neurotrauma: An Overview of the Underlying Mechanisms	10
C-terminus of Hsp70 Interacting Protein (CHIP) and Neurodegeneration: Lessons from the Bench and Bedside	10
Interplay of BDNF and GDNF in the Mature Spinal Somatosensory System and Its Potential Therapeutic Relevance	10
Voxel-wise Functional Connectivity of the Default Mode Network in Epilepsies: A Systematic Review and Meta-Analysis	10
Sceletium for Managing Anxiety, Depression and Cognitive Impairment: A Traditional Herbal Medicine in Modern-Day Regulatory Systems	10
Early Biomarkers and Intervention Programs for the Infant Exposed to Prenatal Stress	10
Cholinesterase Inhibitory Potential of Quercetin towards Alzheimer’s Disease - A Promising Natural Molecule or Fashion of the Day? - A Narrowed Review	10

Microtubule-modulating Agents in the Fight Against Neurodegeneration: Will it ever Work?	10
Neurodevelopment Following Exposure to Antiseizure Medications in Utero: A Review	10
Pharmacological Strategy for Congenital Myasthenic Syndrome with CHRNE Mutations: A Meta-Analysis of Case Reports	10
Melatonin as a Chronobiotic with Sleep-promoting Properties	10
Targeting the Endocannabinoid System in Borderline Personality Disorder: Corticolimbic and Hypothalamic Perspectives	10
Targeting Ionotropic Glutamate Receptors in the Treatment of Epilepsy	10
Treatment of Circadian Rhythm Sleep–Wake Disorders	10
Depression as an Immunometabolic Disorder: Exploring Shared Pharmacotherapeutics with Cardiovascular Disease	10
Poloxamer 188 (P188), A Potential Polymeric Protective Agent for Central Nervous System Disorders: A Systematic Review	10
siRNA Therapeutics: Future Promise for Neurodegenerative Diseases	10
Hexahydrocannabinol Pharmacology, Toxicology, and Analysis: The First Evidence for a Recent New Psychoactive Substance	10
Identifying c-fos Expression as a Strategy to Investigate the Actions of General Anesthetics on the Central Nervous System	9
Depression: An Insight into Heterocyclic and Cyclic Hydrocarbon Compounds Inspired from Natural Sources	9
What About Drug Checking? Systematic Review and Netnographic Analysis of Social Media	9
The Benzydamine Experience: A Systematic Review of Benzydamine Abuse	9
Patients Stratification Strategies to Optimize the Effectiveness of Scavenging Biogenic Aldehydes: Towards a Neuroprotective Approach for Parkinson's Disease	9
Protective Effects of Polydatin Against Dementia-Related Disorders	9
Comparative Analysis of the Pre- and Post-Medication Effects of Antipsychotic Agents on the Blood-Based Oxidative Stress Biomarkers in Patients with Schizophrenia: A Meta-Analysis	9
The Therapeutic Potential and Usage Patterns of Cannabinoids in People with Spinal Cord Injuries: A Systematic Review	9
Dapsone, More than an Effective Neuro and Cytoprotective Drug	9
How to Optimize the Effectiveness and Safety of Parkinson’s Disease Therapy? – A Systematic Review of Drugs Interactions with Food and Dietary Supplements	9
The Lymphatic System In The Brain Clearance Mechanisms - New Therapeutic Perspectives For Alzheimer's Disease	9
The Protective Roles and Molecular Mechanisms of Troxerutin (Vitamin P4) for the Treatment of Chronic Diseases: A Mechanistic Review	9
Putative Roles of Astrocytes in General Anesthesia	9
Fabry Disease: Current and Novel Therapeutic Strategies. A Narrative Review	9
Pharmacological Effects of Saffron and its Constituents in Ocular Disorders from in vitro Studies to Clinical Trials: A Systematic Review	9
The Role of Astrogliosis in Formation of the Syrinx in Spinal Cord Injury	9
Natural Product-based Nanomedicine: Recent Advances and Issues for the Treatment of Alzheimer's Disease	9
Targeting Options of Tumor-Associated Macrophages (TAM) Activity in Gliomas	9
Sex-Specific Association between Antioxidant Defense System and Therapeutic Response to Risperidone in Schizophrenia: A Prospective Longitudinal Study	9
Cholinergic Modulation of General Anesthesia	9