OOIR: Observatory of International Research

Papers

(The median citation count of Protein Journal is 2. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2022-08-01 to 2026-08-01.)

Article	Citations
Utilisation of Carbon Quantum Dots from Hazelnut Husk for Folic Acid (FA) Detection: An Innovative Approach	36
Structural Changes of Apolipoprotein A-I Caused by Hydroxyethyl Starch 130/0.4 Reveals Potential Toxic Mechanisms	34
Rational Design, Synthesis, and Computational Investigation of Dihydropyridine [2,3-d] Pyrimidines as Polyphenol Oxidase Inhibitors with Improved Potency	19
Effect of Organic Solvents on the Activity, Stability and Secondary Structure of asclepain cI, Using FTIR and Molecular Dynamics Simulations	19
Impression of Insect’s Proteolytic Enzyme Cocoonase and Its Application: A Comprehensive Review	19
The Proteostasis of Thymic Stromal Cells in Health and Diseases	17
Up-Regulated Proteins Have More Protein–Protein Interactions than Down-Regulated Proteins	17
Involvement of the non-active site Residues in the Catalytic Activity of NDM-4 Metallo beta-lactamase	17
Infrared Spectral Patterns of Thyroglobulin Bearing Thyroiditogenic Epitopes	15
Kennedy Epitope (KE)-dependent Retrograde Transport of Efficiently Cleaved HIV-1 Envelopes (Envs) and its Effect on Env Cell Surface Expression and Viral Particle Formation	14
Identification of Alternatively Spliced Novel Isoforms of Human HSPB8 Gene	13
Identification of Potential RNAi Targets for Cotton Mealybug (Phenacoccus solenopsis Tinsley) Management	13
Toxoplasma Gondii Importin α Shows Weak Auto-Inhibition	13
N-Linked Glycoproteome Analysis of Diosorea alata Tuber Shows Atypical Glycosylation and Indicates Central Role of Glycosylated Proteins in Tuber Maturation	12
Thermodynamic Evolution of a Metamorphic Protein: A Theoretical-Computational Study of Human Lymphotactin	12
Inhibition of Listeria Monocytogenes HtrA Protease with Camostat, Gabexate and Nafamostat Mesylates and the Binding Mode of the Inhibitors	11
A New Combination: Anti Glypican-3 scFv and Diphtheria Toxin with the Best Flexible Linker	11
Domain Shuffling and Site-Saturation Mutagenesis for the Enhanced Inhibitory Potential of Amaranthaceae α-Amylase Inhibitors	11
Crystal Structure of a Thioredoxin-like Ferredoxin Encoded Within a Cobalamin Biosynthetic Operon of Rhodobacter capsulatus	11
Soluble Expression of Antimicrobial Peptide BSN-37 from Escherichia coli by SUMO Fusion Technology	11
Selection and Molecular Response of AHL-lactonase (aiiA) Producing Bacillus sp. Under Penicillin G-induced Conditions	11
Ferguson Plot Analysis of Chaperone ClpB from Moderate Halophile	10
Heterologous Production of Antimicrobial Peptides: Notes to Consider	10
Proteomic Analysis of Serum Samples in Ovulatory Polycystic Ovary Syndrome and Construction of a Protein Interaction Pathway	10
Molecular Modeling and Optimization of Type II E.coli l-Asparginase Activity by in silico Design and in vitro Site-directed Mutagenesis	10

Delineation of Recombinant Cestode Phosphoenolpyruvate Carboxykinase Activity Co-expressed with Molecular Chaperones	10
Molecular and Computational Analysis Identify Statins as Selective Inhibitors of Human Butyrylcholinesterase	9
Use of 2D FFT and DTW in Protein Sequence Comparison	9
Multiple Protein Profiler 1.0 (MPP): A Webserver for Predicting and Visualizing Physiochemical Properties of Proteins at the Proteome Level	9
Methylglyoxal-Induced Modification of Hen Egg White Lysozyme: Detection of Advanced Glycation End Products by High Resolution Mass Spectrometry	9
gmXtal: Cooking Crystals with GROMACS	9
A Novel Glucose-6-Phosphate Isomerase Exists in Chicken Breast Meat: A Selenium-Containing Enzyme that Should Be Re-recognized Through New Eyes	9
Live Cell Protein Imaging of Tandem Complemented-GFP11-Tagged Coiled-Coil Domain-Containing Protein-124 Identifies this Factor in G3BP1-Induced Stress-Granules	9
Unraveling the interaction between a glycolytic regulator protein EhPpdk and an anaphase promoting complex protein EhApc10: yeast two hybrid screening, in vitro binding assays and molecular simulation	9
Endoplasmic Reticulum Stress: Implications in Diseases	8
Exploring Wheat Leaf Urease for a Sustainable Approach: Purification, Kinetics, and Thermal Stability Characterization	8
Improved Protein Real-Valued Distance Prediction Using Deep Residual Dense Network (DRDN)	8
Engineering Human Pancreatic RNase 1 as an Immunotherapeutic Agent for Cancer Therapy Through Computational and Experimental Studies	8
Editor-in-Chief’s Introduction	8
Identification of Protein–Protein Interaction Associated Functions Based on Gene Ontology	8
Prediction of Solubility of Proteins in Escherichia coli Based on Functional and Structural Features Using Machine Learning Methods	8
Next Generation Sequencing for Potential Regulated Genes and Micro-RNAs of Early Growth Response-1 in the Esophageal Squamous Cell Carcinoma	8
A Novel C-Terminal Small Tail Provides Thermostability of FeSOD Implying a New Mechanism of Protein Heat Resistance	8
Antemortem Stress Regulates Postmortem Glycolysis in Muscle by Deacetylation of Pyruvate Kinase M1 at K141	8
A Retrospective on the Development of Methods for the Analysis of Protein Conformational Ensembles	7
Functional Characterization of Recombinant Endo-Levanase (LevBk) from Bacillus koreensis HL12 on Short-Chain Levan-Type Fructooligosaccharides Production	7
Amine Group Surface-Functionalized Carbon Quantum Dots Exhibit Anti-amyloidogenic Effects Towards Hen Egg White Lysozyme by Inducing Formation of Nontoxic Spherical Aggregates	7
On the Path to Optimal Alchemistry	6
Mechanistic In-Silico Insights into the Anti-quorum Sensing Potential of Coumaric Acid and Syringic Acid in Serratia marcescens with Invitro Analysis	6
HIV Protease Hinge Region Insertions at Codon 38 Affect Enzyme Kinetics, Conformational Stability and Dynamics	6
Investigating the Protective Role of Biochaga Drug on Structural Changes of Bovine Serum Albumin in the Presence of Methyl tert-butyl Ether	6
Rational Design and Production of Bioactive Analogs of Recombinant Human Keratinocyte Growth Factor (rhKGF) with Reduced Aggregation Propensity	6
Targeting Aminoglycoside Acetyltransferase Activity of Mycobacterium tuberculosis (H37Rv) Derived Eis (Enhanced Intracellular Survival) Protein with Quercetin	6
Inhibitor Action of Unsaturated Fatty Acids on Equine Serum Butyrylcholinesterase	6
A Machine Learning Approach to Identify C Type Lectin Domain (CTLD) Containing Proteins	6
Unveiling the Immunostimulatory Potential of the HSPA1A Mini-Chaperones Compared to the HSPA1A and HSP27 Chaperones: In Silico and In Vitro Insights for Vaccine Development	6
Exploring Acoustic Detection of α-Synuclein Fibrils	6
The complex landscape of intracellular signalling in protein modification under hyperglycaemic stress leading to metabolic disorders	5
Simulations of Amyloid-Forming Peptides in the Crystal State	5
Role Transformation of HSPA8 to Heme-peroxidase After Binding Hemin to Catalyze Heme Polymerization	5
The Role of a Loop in the Non-catalytic Domain B on the Hydrolysis/Transglycosylation Specificity of the 4-α-Glucanotransferase from Thermotoga maritima	5
Enhanced Substrate Specificity of Thermostable Cytochrome P450 CYP175A1 by Site Saturation Mutation on Tyrosine 68	5
Effects of Heavy Metal Stress on Seedling Growth and Antioxidant System in Sorghum (Sorghum Bicolor (L.) Moench)	5
Herman Berendsen and Water: Personal Memories	5
Interaction of Cecropin A (1–7) Analogs with DNA Analyzed by Multi-spectroscopic Methods	5
Molecular and Enzymatic Characterization of 9-Cis-epoxycarotenoid Dioxygenases from Mulberry	5
Chemical Modification of the Amino Groups of Human Insulin: Investigating Structural Properties and Amorphous Aggregation of Acetylated Species	5
A Non-competitive Serpin-Like Thrombin Inhibitor Isolated from Moringa oleifera Exhibit a High Affinity for Thrombin	5
Comparative Analyses of Human Exosome Proteomes	5
Expression of Recombinant Stonustoxin Alpha Subunit and Preparation of polyclonal antiserum for Stonustoxin Neutralization Studies	5
Probing Dual Covalent Irreversible Inhibition of EGFR/FGFR4 by Electrophilic-Based Natural Compounds to Overcome Resistance and Enhance Combination Therapeutic Potentials and Management of Hepatocellu	5
Enzymatic Characterization and Coenzyme Specificity Conversion of a Novel Dimeric Malate Dehydrogenase from Bacillus subtilis	5
Significance of Sequence Features in Classification of Protein–Protein Interactions Using Machine Learning	5
An update on Glycerophosphodiester Phosphodiesterases; From Bacteria to Human	5
Lipid Transfer Proteins (LTPs) Partially Purified from Capsicum chinense Jacq. Seeds: Antifungal Properties and α-amylase Inhibitory Activity	4

Expression of Recombinant Tissue Plasminogen Activator - Plasminogen Activator Inhibitor Complex in Mammal Cells as Quality Control Materials in Immunoassay	4
Discovery of New Dual-Target Agents Against PPAR-γ and α-Glucosidase Enzymes with Molecular Modeling Methods: Molecular Docking, Molecular Dynamic Simulations, and MM/PBSA Analysis	4
Molecular Cloning, Expression and Enzymatic Characterization of Tetrahymena thermophila Glutathione-S-Transferase Mu 34	4
Biophysical and Biochemical Characterization of the Receptor Binding Domain of SARS-CoV-2 Variants	4
Rehydration Post-orientation: Investigating Field-Induced Structural Changes via Computational Rehydration	4
The Investigation of the Subtle Structural Discrepancies between Oryza Sativa Recombinant and Plasma-Derived Human Serum Albumins to Design a Novel Nanoparticle as a Taxane Delivery System	4
Herman Berendsen, a Decisive Factor in My Life	4
Refolding, Crystallization, and Crystal Structure Analysis of a Scavenger Receptor Cysteine-Rich Domain of Human Salivary Agglutinin Expressed in Escherichia coli	4
Combining Cryo-EM with Computational Approaches To Revolutionize Structural Biology	4
α-proton Chemical Shift Index and Amide Proton Chemical Shift Temperature Coefficient of Melittin in Methanol: Indicators for a Helix Structure and an Intra-Molecular Hydrogen Bond?	4
Correction: From Crude Extracts to Purity: A Comparative Study of Butyrylcholinesterase Purification	4
The Magical Power of Water: A Reminiscence of Herman Johan Christiaan Berendsen	4
Protein S-Nitrosylation: A Chemical Modification with Ubiquitous Biological Activities	4
Tartrate Dehydrogenase in Bacillus Species: Deciphering Unique Catalytic Diversity Through Kinetic, Structural and Molecular Docking Analysis	3
An Analysis of Intrinsic Protein Disorder in Antimicrobial Peptides	3
Physicochemical Characterization of a Recombinant eCG and Comparative Studies with PMSG Commercial Preparations	3
Exosomes with Engineered Brain Derived Neurotrophic Factor on Their Surfaces Can Proliferate Menstrual Blood Derived Mesenchymal Stem Cells: Targeted Delivery for a Protein Drug	3
Improved Antimicrobial Activity of Bovine Lactoferrin Peptide (LFcinB) Based on Rational Design	3
Inhibitory Action of Omega-3 and Omega-6 Fatty Acids Alpha-Linolenic, Arachidonic and Linoleic acid on Human Erythrocyte Acetylcholinesterase	3
Align-gram: Rethinking the Skip-gram Model for Protein Sequence Analysis	3
Structural and Biochemical Studies on Klebsiella Pneumoniae Enoyl-ACP Reductase (FabI) Suggest Flexible Substrate Binding Site	3
How Azide Ion/Hydrazoic Acid Passes Through Biological Membranes: An Experimental and Computational Study	3
Synthesis and Characterisation of Chickpea Peptides-Zinc Chelates Having ACE2 Inhibitory Activity	3
Microenzymes: Is There Anybody Out There?	3
Unravelling the Significance of Seed Proteomics: Insights into Seed Development, Function, and Agricultural Applications	3
Intermolecular And Dynamic Investigation of The Mechanism of Action of Reldesemtiv on Fast Skeletal Muscle Troponin Complex Toward the Treatment of Impaired Muscle Function	3
Biochemical Characterization of Laccase from Spirulina CPCC-695 and Their Role in Estrone Degradation	3
Computational Insight into Substrate-Induced Conformational Changes in Methionyl-tRNA Synthetase of Mycobacterium Tuberculosis	3
DeepBindPPI: Protein–Protein Binding Site Prediction Using Attention Based Graph Convolutional Network	3
Understanding the Necessity of Regulatory Protein Machinery in Heterologous Expression of Class-III Type of Ocins	3
Influence of Cataract Causing Mutations on αA-Crystallin: A Computational Approach	3
Herman Berendsen’s NMR Research in Groningen and Some Memories from a Fan	3
Herman J. C. Berendsen	3
Improvement of α-amino Ester Hydrolase Stability via Computational Protein Design	3
Comparative Characterization of Plasmodium falciparum Small Heat Shock Proteins and Their Inhibition by Quercetin (3,3′,4′,5,7-Pentahydroxyflavone)	2
Recent Advancements in Biosensors for the Detection and Characterization of Amyloids: A Review	2
Unravelling the Phosphorylation Landscape of Anthrax Toxin Receptor 1: Mechanisms and Functional Insights Through Phosphoproteomic Data Integration	2
The Regulation of TDP-43 Structure and Phase Transitions: A Review	2
Computer-Aided Multi-Epitope Based Vaccine Design Against Monkeypox Virus Surface Protein A30L: An Immunoinformatics Approach	2
Propensities of Some Amino Acid Pairings in α-Helices Vary with Length	2
Bacteriophage Endolysin: A Powerful Weapon to Control Bacterial Biofilms	2
Analyzing VEGFA/VEGFR1 Interaction: Application of the Resonant Recognition Model-Stockwell Transform Method to Explore Potential Therapeutics for Angiogenesis-Related Diseases	2
Conjugation with the Carrier Helped to Reveal acidification-Induced Structural Shift in the Peptide from Phospholipase Domain of Parvovirus B19	2
Proteomic Analysis Reveals Differential Protein Expression Induced by Inhibition of Prolyl Oligopeptidase in Filarial Parasites	2
Selective Attachment of Polyethylene Glycol to Hemerythrin for Potential Use in Blood Substitutes	2
A Comprehensive Review on Machine Learning Techniques for Protein Family Prediction	2
A Novel Trypsin Kunitz-Type Inhibitor from Cajanus cajan Leaves and Its Inhibitory Activity on New Cancer Serine Proteases and Its Effect on Tumor Cell Growth	2
Molecular Insights of an Avian Species with Low Oxygen Affinity, the Crystal Structure of Duck T-State Methemoglobin	2
Enzyme Kinetics Features of the Representative Engineered Recombinants of Chondroitinase ABC I	2
Methotrexate for Drug Repurposing as an Anti-Aggregatory Agent to Mercuric Treated α-Chymotrypsinogen-A	2
Computational and Experimental Approaches Towards Understanding the Role of ATG8 in Autophagy: A Therapeutic Paradigm in Leishmaniasis	2
Efficient Expression in the Prokaryotic Host System, Purification and Structural Analyses of the Recombinant Human ACE2 Catalytic Subunit as a Hybrid Protein with the B Subunit of Cholera Toxin (CTB-A	2
A Proteomics Investigation of Salivary Profiles as Potential Biomarkers for Autism Spectrum Disorder (ASD)	2
The Impact of Terminal Peptide Extensions of Retinal Inosine 5´Monophosphate Dehydrogenase 1 Isoforms on their DNA-binding Activities	2
The Structural Features of MlaD Illuminate its Unique Ligand-Transporting Mechanism and Ancestry	2
Characterization of the Three DHFRs and K65P Variant: Enhanced Substrate Affinity and Molecular Dynamics Analysis	2
Novel Self-Cleaving Affinity Purification Method for Cellular Membrane-Associated Recombinant Paraoxonase-1 (rePON1) Enzyme	2
A Significant Difference in Core PDZ Interactivity of SARS-CoV, SARS-CoV2 and MERS-CoV Protein E Peptide PDZ Motifs In Vitro	2
Development of Hemagglutinin–Neuraminidase Homologous Peptides as Novel Promising Therapeutic Agents Against Peste des Petits Ruminants Virus	2
Site-Directed Mutation of Salicylate Decarboxylase Gene and Mechanism of Ginkgo Acid Decarboxylation	2
Functional and Biochemical Analyses of Glycerol Kinase and Glycerol 3-phosphate Dehydrogenase in HEK293 Cells	2
Expression and Purification of Human Stem Cell Factor and Its Effect on the Growth of A549 Cells	2
Herman Berendsen, an Unforgettable Man	2
Decoding the Structure–Function Relationship of the Muramidase Domain in E. coli O157.H7 Bacteriophage Endolysin: A Potential Building Block for Chimeric Enzybiotics	2