OOIR: Observatory of International Research

Papers

(The TQCC of Medicinal Chemistry is 6. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2022-08-01 to 2026-08-01.)

Article	Citations
Substituted 4H-3,1-benzoxazine-4-one Derivatives as Inhibitors of Cathepsin G	65
A Search for New Amidrazone Derivatives Containing 4-Oxybut-2-enoic Acid Moiety as Antibacterial Agents	54
New Route to the Synthesis of Novel Pyrazolo[1,5-a]pyrimidines and Evaluation of their Antimicrobial Activity as RNA Polymerase Inhibitors	45
Recent Advances in the Biological Profiles of Fluorine-Containing Pyridine and its Derivatives: A Brief Overview	41
Potential Inhibitors of SARS-CoV-2 Developed through Machine Learning, Molecular Docking, and MD Simulation	40
2-Substituted Benzoxazoles as Potent Anti-Inflammatory Agents: Synthesis, Molecular Docking and In vivo Anti-Ulcerogenic Studies	40
Identification of Potential Dual HDAC6 and HSP90 Inhibitors for the Treatment of Cancer using Molecular Docking, Molecular Dynamics and MM/PBSA Studies: A Comprehensive In Silico Study	37
Exploration of Fluorine-Containing Biguanide Analogues with Various Branches: Their Design, Synthesis, and Anti-Proliferative Mechanisms	28
Exploring Recent Advances in the Pharmacological Activities of Pyrazole Compounds: A Comprehensive Review	25
Pyrazolo - Pyrimidines as Targeted Anticancer Scaffolds - A Comprehensive Review	25
A Comprehensive Review: Synthesis and Pharmacological Activities of 1,3,4-Oxadiazole Hybrid Scaffolds	23
Promising Molecular Targets Related to Polyamine Biosynthesis in Drug Discovery against Leishmaniasis	22
Synthesis, Antimicrobial Activity, DFT, Molecular Docking, and Dynamic Simulations of Trityl Mannopyranoside Derivatives for Potential Antibacterial Agents	22
Incorporating Antimicrobial Activity During Synthesis of New Acid-Azo Dyes: Thermal Stability and Application on Various Fabrics	20
Preface	20
The Catalysts-Based Synthetic Approaches to Quinolines: A Review	19
Synthesis, Docking, and Biological Studies of Pyrazine Derivatives as Antimycobacterial Agents	18
Design, Synthesis, in silico and in vitro Evaluation of New Combretastatin A-4 Analogs as Antimitotic Antitumor Agents	18
GPR18 and GPR55-related Ligands Serving as Antagonists or Agonists: Current Situation, Challenges and Perspectives	17
Evaluation of the Anticancer Potential of Nitro-Benzimidazole Derivatives in Breast Cancer	17
A Review of the Medicinal Importance and Perspectives of the 2-isoxazoline Scaffold	17
Preface	17
Abrogating Oxidative Stress as a Therapeutic Strategy Against Parkinson’s Disease: A Mini Review of the Recent Advances on Natural Therapeutic Antioxidant and Neuroprotective Agents	16
Targeting Breast Cancer: Novel Dihydropyrimidinones As Potent Eg5 Inhibitors	16
Novel Caffeic Acid - Zinc Acetate Complex: Studies on Promising Antidiabetic and Antioxidative Synergism Through Complexation	15

Blueberries and Their Polyphenols: A Review of the Evidence and the Potential Impact on Inflammation, Oxidative Stress, Vascular and Cardiometabolic Function	15
Pyrazoline Derivatives: Exploring the Synthesis and Development of New Ligands for Anti-Cancer Therapy	14
Synthesis and Structural Activity Relationship Study of Ursolic Acid Derivatives as Antitubercular Agent	13
An Explicative Review on the Progress of Quinazoline Scaffold as Bioactive Agents in the Past Decade	13
Exploring Phytochemicals as Potential Inhibitors of Cancer Cell Metabolic Pathways: A Computational Study	12
Design and Synthesis of Novel Celecoxib Analogues with Potential Cytotoxic and Pro-apoptotic Activity against Breast Cancer Cell Line MCF-7	12
Synthesis and Antiproliferative Activity Evaluation of B-norcholesterol-6- amide Compounds	12
WITHDRAWN: Bismuth(III) Complexes with Schiff Bases: Synthesis, Characterization, Interaction with Biomolecules, Antioxidant and Antimicrobial Activity	12
Revisiting Purine Nucleoside Cholinesterase Inhibitors - An Experimental Glycon Structure/Activity Relationship Study	12
Integrating Machine Learning and Pharmacophore Features for Enhanced Prediction of H1 Receptor Blockers	12
Application and Progress of Machine Learning in Pesticide Hazard and Risk Assessment	11
Synthesis, Molecular Docking Studies and Biological Evaluation of Thiazolyl Hydrazone Derivatives of Chromone-3-carbaldehyde as Potent Anti-Oxidant and Anti-Inflammatory Agents	11
Recent Advances in Nitrogen-Containing Heterocyclic Scaffolds as Antiviral Agents	11
In silico and in vitro Analysis of Secondary Metabolites of Pleurotus djamor Against Targets of Haemonchus contortus	11
Synthesis, Characterization, and In Vitro and In Silico Studies of New Triazole Derivatives as Aromatase Inhibitors	11
Developing Safer Anticoagulant Candidates: Structure-Activity Relationship Studies of 5-Amino-Triazole-Based FXIIa Inhibitors	11
Drug Repurposing against the PurS Subunit of Phosphoribosylformylglycinamidine Synthase in Methicillin- and Oxacillin-Resistant Staphylococcus Aureus: In vitro and In silico Studies	10
1,3,4-Thiadiazole: A Versatile Pharmacophore of Medicinal Significance	10
Nitrogen-fused Heterocycles: Empowering Anticancer Drug Discovery	10
In Vitro Evaluation of p-Toluenesulfonyl Hydrazones as Anti-Trypanosoma cruzi and Leishmanicidal Agents	9
Synthetic Methods for Various Chromeno-fused Heterocycles and their Potential as Antimicrobial Agents	9
New Approach as Inhibitor Against Head-Neck Cancer by In silico, DFT, FMOs, Docking, Molecular Dynamic, and ADMET of Euphorbia tirucalli (Pencil Cactus)	9
Diaryl Ether Derivatives as Dual Inhibitors of Selective COX-2 and EGFR: Synthesis, In silico, and In Vitro Analysis	9
Antioxidant and Antimicrobial Potential, BSA and DNA Binding Properties of Some 3-Hydroxy-3-Pyrrolin-2-Ones Bearing Thenoyl Fragment	9
Would the Development of a Multitarget Inhibitor of 3CLpro and TMPRSS2 be Promising in the Fight Against SARS-CoV-2?	9
Structural Scaffolds as Anti- Alzheimer Agents	9
Computational Screening, ADME Study, and Evaluation of Benzothiazole Derivatives as Potential Anticancer Agents	8
Design, Synthesis and Anticonvulsant Activity of Cinnamoyl Derivatives of 3,4,6,7,8,9-hexahydrodibenzo[b,d]furan-1-(2H)-one Oxime	8
Acknowledgements to Reviewers	8
Design, Synthesis and Biological Evaluation of Novel N-Alkyl-4-Methyl-2,2- Dioxo-1H-2λ6,1-Benzothiazine-3-Carboxamides as Promising Analgesics	8
Efficient Synthesis of Mannopyranoside-based Fatty Acyl Esters: Effects of Acyl Groups on Antimicrobial Potential	8
Discovery of Novel 1,3,4-oxadiazole-based Inhibitors Against Urease and Diabetes: Design, Synthesis, SAR, Biological, and Molecular Docking Screening	8
Structure-Based Discovery of Potent Staphylococcus aureus Thymidylate Kinase Inhibitors by Virtual Screening	8
Synthesis and Antibacterial Evaluation of Novel Small-Molecule Antibacterials of a Reduced Acridine Structure in S. aureus Strains Including MRSA	7
Expanding Therapeutic Horizons with Indazole-Based Compounds: A Review of Anticancer, Antimicrobial, and Neuroprotective Applications	7
Antioxidant and Cytotoxic Activity of the Aporphine Alkaloid (Boldine) Against DMH-induced Colorectal Carcinogenesis in Wistar Rats: An In silico, In vitro, and In vivo study	7
Unveiling the Anti-cancer Potential of Oxadiazole Derivatives: A Comprehensive Exploration of Structure-Activity Relationships and Chemico-Biological Insights	7
In-silico Investigations for the Identification of Novel Inhibitors Targeting Hepatitis C Virus RNA-dependent RNA Polymerase	7
Histone Deacetylase (HDAC) Inhibitors: Research and Therapeutic Applications in Cancer and Neurodegenerative Diseases: A Mini-review	7
Quinolones: The Cornerstone of the Advanced Era in Therapeutics	7
Promising Potential of Curcumin and Related Compounds for Antiviral Drug Discovery	7
Screening of Novel Inhibitors Targeting the Non-ATP-binding Domain of Staphylococcus aureus SecA1	7
In silico Study of Novel Tryptanthrin-Based Topoisomerase Inhibitors	7
Synthesis and Evaluation of Antibacterial and Antifungal Activities In vitro and In silico of Novel Morpholinoalkoxychalcones	7
Exploring the Therapeutic Potential of Pyrazole-Based Scaffolds in Parkinson’s Disease: Recent Progress and SAR Insights	6
DPP-IV and FAP-α as Targets of Drug Design: A Comparative Structural Analysis of Molecular Features and Biological Implications	6
Antimicrobial Potential of Polyphenols: An Update on Alternative for Combating Antimicrobial Resistance	6
A Review on the Development of Novel Heterocycles as α-Glucosidase Inhibitors for the Treatment of Type-2 Diabetes Mellitus	6
Styrylquinolines Derivatives: SAR Study and Synthetic Approaches	6
In Silico Discovery and Predictive Modeling of Novel Acetylcholinesterase (AChE) Inhibitors for Alzheimer's Treatment	6

A Series of Trifluoromethylisoxazolyl- and Trifluoromethylpyrazolyl- Substituted (Hetero)aromatic Sulfonamide Carbonic Anhydrase Inhibitors: Synthesis, and Convenient Prioritization Workflow for Furth	6
2-Quinolinone Derivatives as Dual Cholinesterase Inhibitors: Experimental and Computational Insights	6
Effective Synthesis of Dopamine Dimer	6
Determination of Novel SARS-CoV-2 Inhibitors by Combination of Machine Learning and Molecular Modeling Methods	6
Platinum Group Metals against Parasites: State of the Art and Future Perspectives	6
In Silico Analysis and Molecular Docking of Human Antimicrobial Peptides for Targeting Monkeypox Virus: Potential Therapeutic Implications of Histatin 5 Peptide	6
Design and Synthesis of (2,3-dichloro-4-(3-(substituted Phenyl)acryloyl) phenoxy) Substituted Carboxylic Acid as Potent Glutathione-s-transferase Inhibitors, Anti-breast-cancer Agents and Enhancing Th	6