OOIR: Observatory of International Research

Papers

(The TQCC of Current Pharmaceutical Analysis is 2. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-09-01 to 2025-09-01.)

Article	Citations
UPLC-MS/MS Determination of Chlorogenic Acid, Hyperoside and Astragalin in Plasma and its Pharmacokinetic Application in Liver Injury Rats	60
Analysis of Shenhuang Capsule using HPLC: Method Development, Validation, and Application	36
Application of a Quantitative Proton Nuclear Magnetic Resonance Method for the Determination of Protopine in Radix Dactylicapnotis	35
Non-enzymatic Glucose Detection by Fe₂O₃ Nanorods-reduced Graphene under Physiological pH	31
Characteristics, Biological Activities, Synthesis, and Methods for the Determination of Brexpiprazole in Different Matrices	27
Effect of Diosmin on Pharmacokinetics and Pharmacodynamics of Rivaroxaban in Rats	22
Head Space GC-MS/MS Method for Quantification of Five Nitrosoamine- Genotoxic Impurities in Metformin HCl	20
Explore the Constituents and Mechanism of Traditional Chinese Medicine Preparation Zhachong Shisan Pills Based on HPLC-QTOF-MS and Network Pharmacology	19
Integrated lipidomics and computational analyses reveal cardiolipin dysregulation as a therapeutic target in bortezomib-induced peripheral neuropathy	19
Investigation of the Permeability of Antiretroviral Drugs Lamivudine and Valganciclovir via Single-Pass Intestinal Perfusion (SPIP) Method	13
Comparison of ZIC-HILIC Columns for the Simultaneous Analysis of Antiviral Drugs in Dosage Forms by Hydrophilic Interaction Liquid Chromatography	13
Pitfalls and Opportunities in the Execution of Quality by Design in Analytical Sciences	13
A systematic and comprehensive review of the properties and synthesis of anticancer heterocyclic natural products	12
An Integrated Strategy for Rapid Screening of Multi-target Lead Compounds for the Treatment of Alzheimer's Disease from Traditional Chinese Medicines by UHPLC Combined with High-throughput Screening:	11
Simultaneous Determination of Six Bioactive Components of Astragali Radix in Rat Plasma Using Triple Quadrupole LC/MS and its Application to a Pharmacokinetic Study	10
Determination of Acotiamide in Human Plasma by LC-MS/MS and its Application to a Pharmacokinetic Study	10
Maraviroc Oral Disintegration Tablet: Analytical Design of Experiments (DoE) for Assessment and Comparison of In vitro Dissolution Profiles	10
Evaluation and Application of ZIC-HILIC Columns Selectivity for Four Angiotensin II Receptor Blockers in Pharmaceutical Formulations	9
Determination of pH-Solubility Profile and Development of Prediction Models for pH-Dependent Solubility of Atorvastatin Calcium	8
Determination of Trans-loxoprofen-alcohol Tromethamine in Pregnant SD Rats by a Validated LC-MS/MS Method：Application to a Toxicokinetics and Tissue Distribution Study	8
Mini-Review on Bioanalytical Estimation of Brinzolamide	7
Analytical Methods for the Quantification of Cisplatin, Carboplatin, and Oxaliplatin in Various Matrices over the Last Two Decades	6
Stability Indicating Method for Known and Unknown Impurities Profiling for Vildagliptin in Vildagliptin Tablet	6
Simultaneous Determination of D-amino Acids in Rat Urine by Highperformance Liquid Chromatography-tandem Mass Spectrometry Method: Application to Investigate the Clinical Value of D-amino Acids in the	6
Charge Variants Analysis of a Bispecific Antibody Using a Fully Automated One-step Capillary Isoelectric Focusing - Mass Spectrometry Method	6

Development and Validation of Teneligliptin Stereoisomers by HPLC Using Cellulose Based Immobilized Polysaccharide Chiral Stationary Phase	6
Bioinformatic methods uncover 5 diagnostic biomarkers associated with drug resistance and metastasis for gastrointestinal stromal tumor	5
Ionic Liquids, Microextraction Methods and Capillary Electrophoresis in Biomedical Research	5
iTRAQ-based Proteomic Analysis Unveils NCAM1 as a Novel Regulator in Doxorubicin-induced Cardiotoxicity and DT-010-exerted Cardioprotection	5
Analyzing Paraben Degradation in Parenteral Formulations with High-performance Liquid Chromatography	5
Review on Analytical Methodologies, Chemical and Therapeutic Perspectives of Curcumin: A Ubiquitous Natural Molecule	5
In silico exploration of Aloe vera leaf compounds as dual AChE and BChE inhibitors for Alzheimer’s disease therapy	5
Exploring antiproliferative potential, in silico docking, and molecular dynamics of pyrimidine-morpholine hybrid molecules	5
Comprehensive Study on the Chemical Profile and Anti-Tumor Activity of Secondary Metabolites Produced by Aspergillus niger	5
Development and Validation of a Simple HPLC-UV Method to Assay DEET Repellents and its Application to Different Commercial Forms	5
Validation of RP-HPLC Method for Determination of Omeprazole in Dissolution Media and Application to Study in-vitro Release from Solid- SNEDDS	5
Measurement Uncertainty and Validation for Quantification of Marijuana Metabolite: (−)-11-nor-9-Carboxy-Δ9-THC in Human Urine by GC-MS/MS	4
Acknowledgements to Reviewers	4
Metabolic Study of Benzamidenafil using Liquid Chromatography Quadrupole Time-of-Flight Mass Spectrometry	4
Studies on the Anti-HBV Mechanism of Syringopicroside Based on Serum Metabolomics	4
Determination of Thrombin Activity by Reversed-phase High Performance Liquid Chromatography	4
A Quantitative LC-MS/MS Method for the Simultaneous Determination of the Presence of R-α-lipoic Acid and S-α-lipoic Acid After Protein Precipitation in Rat Plasma and its Application in a Toxicokineti	4
Protein Species of Origin Determination By NMR Relaxometry	4
Molecular Absorption Scanning and Assay of Serotonin Reception Inhibitor Antidepressant Drugs	4
Simultaneous Detection of Phillyrin and its Three Metabolites in Rat Bile, Excrement and Urine via HPLC-ESI-MS/MS Quantitative Method	4
Structure Analysis of Unsaturated Polymyxin E Components Based on High-Performance Liquid Chromatography - Quadrupole/ Time of Flight Tandem Mass Spectrometry and Photochemical Reaction	4
Importance of Method Validation in the Analysis of Biomarker	3
Validation of the T-47D Cell Culture Bioassay for the Potency Assessment of Botulinum Neurotoxin Type A	3
Detection of Diuretic Doping by Capillary Electrophoresis and Electrochemical Technology: A Mini-Review	3
Integrating Organ-on-chip Models In Drug Discovery: A Comprehensive Review on Innovations and Implications	3
Development and Validation of a Reliable LC-MS/MS Method for Simultaneous Quantification of Hydrochlorothiazide in the Presence of Different Co-formulated Anti-hypertensive Medications in Biological M	3
Universally Applicable Methods for Comprehensive Risk Assessment of Elemental Impurities in Vitamin A and D Preparations	3
Formulation and evaluation of apigenin-loaded microsponge gel for effective angioedema therapy	3
A Validated 2D-LC-UV Method for Simultaneous Determination of Imatinib and N-desmethylimatinib in Plasma and its Clinical Application for Therapeutic Drug Monitoring with GIST Patients	3
Eco-friendly Spectrophotometric Methods for Assessment of Alfuzosin and Solifenacin in their new Pharmaceutical Formulation; Green Profile Evaluation via Eco-scale and GAPI Tools	3
Identification of diagnostic biomarkers and therapeutic targets for abdominal aortic aneurysms based on disulfidptosis mechanism	3
Simultaneously Determining Seven Second-Line Anti-TB Drugs by UHPLC- MS: Application for TDM in HIV-TB Patients	3
Validation of GF-AAS Method for the Determination of Aluminium Content in Human Albumin Finished Product	3
Determination of Two Potential Genotoxic Impurities in Crisaborole API by UPLC-MS/MS	3
Development and Validation of an Eco-Friendly Liquid Chromatography- Tandem Mass Spectrometry Method for Rapid Quantification of Γ-Aminobutyric Acid in Cordyceps sinensis and its Related Species	3
Research Progress on Quantification Methods of Drug Concentration of Monoclonal Antibodies	3
Distribution, Metabolism, Excretion and Toxicokinetics of Vitexin in Rats and Dogs	3
Stability Study and Simultaneous Determination of Norepinephrine, Moxifloxacin, and Piperacillin + Tazobactam Mixtures Applied in Intensive Care Medicine	3
Identification, Characterization, and the Determination of Process-related Impurities in Minodronic Acid Bulk Drug	3
Development and Validation of Stability-Indicating RP-HPLC Method for the Estimation of Fisetin in Novel Cubosomal Nanoformulation: Application to the Marketed Formulation and Selected Plant Extracts	3
A Diagnostic Tool for Good Chromatographic Practices Applied to HPLC in Pharmaceutical Quality Control	3
Metabolic Profiling Techniques and Their Application in Cancer Research	3
Development and Validation of a UPLC-MS/MS Method for the Simultaneous Determination of Verapamil and Trandolapril in Rat Plasma: Application to a Pharmacokinetic Study	3
Determination of three Unsaturated Fatty Acids in Pressure Ulcer Rats Using A UPLC-MS/MS Method	3
A Review on Analytical Method Development for the Estimation of a Potent Muscarinic Receptor Antagonist Tolterodine Tartrate	2
Development of Attenuated Total Reflectance Fourier Transform Infrared Spectroscopy Coupled with Multivariate Classification Chemometric Model for Routine Screening of Paracetamol, Ibuprofen, and Aspi	2
Method Validation and Monitoring of N-nitrosodimethylamine in Metformin Hydrochloride Products in China by GC-MS/MS	2
Establishment and Validation of a Robust Reversed-Phase HPLC Method for the Determination of Calotropis gigantea in Bulk Material and Marketed Product	2
Development of Acid-Neutralization and In Vitro Dissolution to Evaluate the Overall Quality of Compound Aluminum Hydroxide Tablets	2
Application of Chemometrics-assisted HPLC-DAD Strategies for Simultaneous Determination of Paracetamol, Pseudoephedrine HCl, Dextromethorphan HBr, Doxylamine Succinate and Saccharin in Syrup Formulati	2

Determination of Spermidine and other 10 Biogenic Amines in Radix astragali (Huang qi) by HPLC-DAD with Precolumn Derivatization	2
Pharmacokinetic Studies of Gypenoside XLVI in Rat Plasma using UPLC-MS/MS Method	2
Development and Validation of A High-Performance Liquid Chromatography- Mass Spectroscopy Assay for the Bioequivalence Study of Guanfacine Extended Release (GXR) Tablet in Human Plasma	2
Green Analysis by Eco-scale Assessment for Quality Control of Azithromycin Tablets	2
Utilization of Experimental Design for the Establishment and Optimization of RP-HPLC Method for the Estimation of Two Selective Serotonin Reuptake Inhibitors/benzodiazepines Combinations in the Presen	2
Advancing pharmaceutical research: A comprehensive review of cutting-edge tools and technologies	2
Pharmacokinetics Study of Rabdosia rubescens Drop Pills Based on UPLC-MS/MS	2
Acknowledgements to Reviewers	2
Identification of Method-Induced Artifacts and Light Chain C-terminal Extension Sequence Variants in Therapeutic Monoclonal Antibodies by Complementary Analytical Methods	2
Molecular Docking and Dynamic Simulation Approach to Target Penicillin- Binding Protein 1B (LpoB) of Salmonella typhimurium with Flavonoids	2
Methods for Analysis of Fluorinated Quinolones in Mixtures with Nitroimidazole Antibacterial Drugs	2
Efficient Green Solvent Extraction and Bioassay Studies of Favipiravir in Rat Dried Blood Spots Using Ionic Liquid-based Dispersive Liquid-liquid Microextraction (IL-DLLME) Coupled with HPLC-PDA: Appl	2
Development of Simple HPLC-UV Method for the Simultaneous Determination of Repaglinide, Dexamethasone, and Remdesivir, and its Application to Synthetic Mixture and Human Plasma	2
Diagnosis Model of Hydrogen Sulfide Poisoning Based on Support Vector Machine	2
Unveiling Cloperastine Fendizoate Degradation Using MS/MS: A Novel HPLC Method for Simultaneous Analysis with Parabens and Degradant Characterization	2
Determination of Endocrine Disruptor Bisphenol-A Leakage from Different Matrices of Dental Resin-based Composite Materials	2
Analytical Method Development and Validation to Determine Oxidized Follitropin Recombinant Follicle Stimulating Hormone (rFSH) Injection by RP-HPLC	2
Strategies for the Separation and Quantification of Non-Steroidal Anti- Inflammatory Drugs Using ZIC-HILIC-HPLC with UV Detection	2
Boron-doped Diamond Electrochemical Sensors: A Promising Approach in the Therapy Of Human Ailments	2
A Review: Drug Excipient Iincompatiblity by Ftir Spectroscopy	2
Researches on Detection of Related Substances in Drugs	2
Pharmacokinetics and Tissue Distribution Study of Daphnoretin in Ethanol Extract from the Roots of Wikstroemia Indica in Rats by a Validated UPLC-MS/MS Method	2
Development and Application of Chitosan Nanogel as a Sorbent for Methotrexate Extraction	2
Isolation and Characterization of An Allergic Dimer Impurity in Cefmenoxime Hydrochloride by NMR and HR-MS Method	2
DFT, molecular docking and receptor inhibition analysis of neuromodulatory molecule- dopamine	2
Spectrophotometric Determination of Vitamin B1 in Dosage forms Using Drugs Compounds as Reagents by Normal and Reverse Flow Injection Methods	2
Improved Detection of Veterinary Drug Residues: Advancing Analytical Techniques to Ensure Food Safety	2
An LC-MS/MS Method for the Pharmacokinetic and In Vitro Metabolism Studies of Praeruptorin A in Rat	2