OOIR: Observatory of International Research

Papers

(The TQCC of Current Pharmaceutical Analysis is 2. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-04-01 to 2025-04-01.)

Article	Citations
Therapeutic potential of natural products in stress granules: Underlying molecular mechanisms and future perspectives	52
Analytical Protocol for Monitoring Workplace Surface Contamination with Capecitabine	30
Characteristics, Biological Activities, Synthesis, and Methods for the Determination of Brexpiprazole in Different Matrices	28
Development and Validation of a UPLC-MS/MS Method for the Simultaneous Determination of Verapamil and Trandolapril in Rat Plasma: Application to a Pharmacokinetic Study	18
Ultra-Performance Liquid Chromatography Coupled with a Triple Quadrupole Mass Spectrometric Method for the Quantification of Antiepileptic Drugs Methsuximide and Normesuximide in Human Plasma and its	11
Method Development of Clarithromycin by Chromophore Addition through Chemical Derivatization	11
Design Expert-supported Method Development and Validation of Cilostazol in Pharmaceutical Formulation Using High-performance Liquid Chromatography	10
Effect of Diosmin on Pharmacokinetics and Pharmacodynamics of Rivaroxaban in Rats	10
Development and Validation of an Analytical RP-HPLC Method for Simultaneous Estimation of Losartan and its Active Metabolite (EXP-3174) in Isolated Perfused Rat Liver	10
Determination of Total Arsenic, Soluble Arsenic, Total Mercury and Soluble Mercury for a Realgar and Cinnabar-containing Traditional Chinese Medicine Compound Niuhuang Xiaoyan Capsule by Semi-bionic E	10
An Overview of Biotechnological Drug’s Various Techniques of Downstream Process, Guideline’s and Different Chromatographic Analysis	10
Determination of Two Potential Genotoxic Impurities in Crisaborole API by UPLC-MS/MS	10
Novel “HYDALJSS08” Hydroalcoholic Polyherbal Formulation Development and Ultra-performance Liquid Chromatographic Separation, Estimation of Andrographolides in Andrographis paniculata whole Plants and	9
Sustainable Pharmaceutical Preparation Methods and Solid-state Analysis Supporting Green Pharmacy	8
Systemic Optimization and Validation of RP-HPLC Method for the Estimation of Ritonavir from Hybrid Polymeric Nanoparticles in Rat Plasma	6
Smart Multivariate Spectrophotometric Assisted Techniques for Simultaneous Determination of Ephedrine Hydrochloride and Naphazoline Nitrate in the Presence of Interfering Parabens	6
Evaluation of Clinical Distribution and Antimicrobial Resistance of Klebsiella Pneumoniae	6
A Rapid Method for the Determination of Buprenorphine and Norbuprenorphine in Urine by UPLC-MS/MS	6
Spectroscopic and Chromatographic Estimation of Some Sartans and their Combinations with Thiazide Diuretics: A Review	6
Development and Validation of a High-Performance Thin-Layer Chromatography Method for Simultaneous Qualitative and Quantitative Analysis of Scutellarin and Scutellarein in S. barbata D. Don	6
Development and Validation of a Reliable LC-MS/MS Method for Simultaneous Quantification of Hydrochlorothiazide in the Presence of Different Co-formulated Anti-hypertensive Medications in Biological M	5
Development and Validation of an Eco-Friendly Liquid Chromatography- Tandem Mass Spectrometry Method for Rapid Quantification of Γ-Aminobutyric Acid in Cordyceps sinensis and its Related Species	5
Universally Applicable Methods for Comprehensive Risk Assessment of Elemental Impurities in Vitamin A and D Preparations	5
Application and Development of Targeted Fishing Technology in Natural Product Screening - A Simple Minireview	5
Metabolic Profiling Techniques and Their Application in Cancer Research	5

Quantitation of Conjugation-related Residual Solvents in Antibody Drug Conjugates using Headspace Gas Chromatography	5
Analyzing Hair for Drug Traces: A Review of Electrochemical Approaches	5
Head Space GC-MS/MS Method for Quantification of Five Nitrosoamine- Genotoxic Impurities in Metformin HCl	5
Analytical Aspects for Evaluation of Pharmaceutical Products: A Mini- Review	4
Development and Validation of Stability Indicating RP-HPLC Method for the Estimation of Pirtobrutinib and Characterization of its Degradants by LC - MS	4
Characterization of Carbamide Peroxide: Stability Studies, and Degradation Kinetics under Isothermal Conditions for Industrial Application	4
Identification of In Vivo Metabolites of a Potential Anti-tumor Drug Candidate AMAC, in Rat Plasma, Urine and Feces Samples Using UHPLC/QTOF /MS/MS	4
TLC-surface Enhanced Raman Spectroscopy Hyphenated Technique: An Excellent Tool for Modern Analysis	4
Study and Determination of Aluminum in Dextran 40 Glucose Injection by ICP-MS	4
Explore the Constituents and Mechanism of Traditional Chinese Medicine Preparation Zhachong Shisan Pills Based on HPLC-QTOF-MS and Network Pharmacology	4
Application of a HPLC-Q/TOF Method with Post-column Compensation for Separation and Identification of Polar Impurities in Cytidine Disodium Triphosphate for Injection	4
Determination of Mefuparib in Rat Plasma and its Application to Pharmacokinetics by a Simple and Rapid UPLC-MS/MS	4
Formulation and Evaluation of Apigenin-Loaded Microsponge Gel for Effective Angioedema Therapy	4
Non-enzymatic Glucose Detection by Fe₂O₃ Nanorods-reduced Graphene under Physiological pH	4
Chemical Composition of Essential Oil and In Vitro Biological Activities of Dryopteris marginalis L.	3
Voltammetric Determination of Diazepam on Antimony Film Screen- Printed Electrode in Pharmaceutical Formulations	3
Therapeutic Monitoring of Plasma Digoxin for COVID-19 Patients Using a Simple UPLC-MS/MS Method	3
A Diagnostic Tool for Good Chromatographic Practices Applied to HPLC in Pharmaceutical Quality Control	3
The Metabolism of Portulacatone B from Portulaca oleracea L. in Rats by UHPLC-ESI-Q-TOF/MS	3
Integrated lipidomics and computational analyses reveal cardiolipin dysregulation as a therapeutic target in bortezomib-induced peripheral neuropathy	3
Analysis of Organic Impurities of Besifloxacin Hydrochloride by High-Performance Liquid Chromatography with Isocratic and Gradient Elution	3
Analysis of Organic Components in Various Butyl Rubber Closures and their Compatibility Study with Cefamandole Nafate by HPLC/GC-MS	3
Metabolic Changes in Rat Plasma After Epilepsy by UPLC-MS/MS	3
A Validated LC-MS/MS Method for the Determination of Mezlocillin in Plasma: An Adapted Method for Therapeutic Drug Monitoring in Children	3
Application of a Quantitative Proton Nuclear Magnetic Resonance Method for the Determination of Protopine in Radix Dactylicapnotis	3
Simultaneously Determining Seven Second-Line Anti-TB Drugs by UHPLC- MS: Application for TDM in HIV-TB Patients	3
Distribution, Metabolism, Excretion and Toxicokinetics of Vitexin in Rats and Dogs	3
Validated RP-LC Methods for Investigating the Degradation Behavior of Acefylline: Application for Analysis in Two Binary Mixtures	3
Design and Validation of a Stability-Indicating RP-HPLC Technique for Quantifying Ivacaftor in Bulk and Commercial Formulations	3
Impurity profiling and forced degradation studies of angiotensin (AT1) blockers: A review	3
An acyl pyrrole compound 361B promotes angiogenesis and improves hindlimb ischemia recovery	3
Metabolic Changes in Hyperlipidemic Rats After The Administration of Xuezhikang	3
Difference of Chemical Compositions in Fu Zheng Fang with Different Dosage Forms Based on HPLC-Q-Exactive Orbitrap/MS Combined with Multivariate Statistical Analysis	3
UPLC-MS/MS Determination of Chlorogenic Acid, Hyperoside and Astragalin in Plasma and its Pharmacokinetic Application in Liver Injury Rats	3
Analysis of Shenhuang Capsule using HPLC: Method Development, Validation, and Application	3
Synthesis, Structure Confirmation of Deuterium-substituted Kynurenine and the Conformation Analysis of Kynurenine in Daptomycin	3
Pitfalls and Opportunities in the Execution of Quality by Design in Analytical Sciences	3
Nanotechnology based electrochemical (bio)sensors for insulin/hormone sensing	3
A Review on PCR and POC-PCR - A Boon in the Diagnosis of COVID-19	3
A New Stability-indicating Chiral RP-HPLC Method for the Determination of Degradation Products in Meclizine Hydrochloride	2
A Complete Roadmap of Analytical Quality by Design in Various Analytical Techniques	2
Identification of Method-Induced Artifacts and Light Chain C-terminal Extension Sequence Variants in Therapeutic Monoclonal Antibodies by Complementary Analytical Methods	2
A Nondestructive and Rapid Method for the Determination of Triamterene Content by Transmission Raman Spectroscopy Combined with Chemometrics	2
Metabolite Fingerprinting of Novel Streptomyces UK-238 from the Himalayan Forest	2
Ultrafiltration-based Sample Preparation for Pharmaceutical Analysis	2
Molecular Docking and Dynamic Simulation Approach to Target Penicillin- Binding Protein 1B (LpoB) of Salmonella typhimurium with Flavonoids	2
Rapid Development and Validation of Atoltivimab, Maftivimab and Odesivimab in Pharmaceutical Dosage form by using the RP-HPLC Method	2
Integrated Quality by Design (QbD) Approach for Stability Indicating RPHPLC Method for the Estimation of Tadalafil Hydrochloride in Bulk Drug and Pharmaceutical Formulations	2
Research Progress on Quantification Methods of Drug Concentration of Monoclonal Antibodies	2
RP-HPLC In-Vitro Dissolution Method Development and Validation for Determination of Olmesartan Medoxomil, Chlorthalidone and Cilnidipine Drug Combinations	2

Simultaneous Determination of Four Bioactive Flavonoids in Rat Plasma by UPLC-MS/MS and Comparative Pharmacokinetic Study after Oral Administration of Danyikangtai Powder and Three Compatibilities	2
A Review of the Characteristics, Properties and Methods for Quantification of Roxithromycin	2
Determination of Tyrosine Kinase Inhibitor Icotinib in Rat Plasma using UPLC-MS/MS and its Application In vivo Pharmacokinetic	2
Effects of Sodium Hypochlorite and Chlorine Dioxide on Human Root Canal Dentine: An ATR-FTIR Spectroscopy Study	2
Determination of Impurities in Perampanel Bulk Drugs by High- Performance Liquid Chromatography and Gas Chromatography	2
A Review: Recent Analytical Applications on Anti-epileptic Agents	2
Investigation and Analytical Applications of the Reaction of N1-methylnicotinamide and Active Methylene Containing Drugs	2
Recent Trends in the Detection of Alkaloids through Analytical, Bioanalytical, and Electrochemical Techniques	2
Use of Chemical Reagents in Non-fluorescent Pharmaceutical Labels: A Comprehensive Review	2
Simultaneous Determination of Six Bioactive Components of Astragali Radix in Rat Plasma Using Triple Quadrupole LC/MS and its Application to a Pharmacokinetic Study	2
Quality by Design-driven Analytical Method: A Quality Risk Management-Based Liquid Chromatography Method for Daclatasvir and Characterization of its Putative Degradants by LC-MS/MS	2
A Rapid and Selective UPLC-MS/MS Assay for Accurate Analysis of Apatinib in Rat Plasma and its Application to a Pharmacokinetic Study	2
Analytical and Bioanalytical Methods for the Quantification of the Nucleotide Polymerase Inhibitor - Sofosbuvir: A Critical Review (2015-2021)	2
Azithromycin Nanosuspension Preparation using Evaporative Precipitation into the Aqueous Solution (EPAS) Method and its Comparative Dissolution Study	2
Determination of Acotiamide in Human Plasma by LC-MS/MS and its Application to a Pharmacokinetic Study	2
Development and Validation of LC-MS Method for Determination of Genotoxic Impurity N, O-Dimethyl Hydroxylamine by Chemical Derivatization in Investigational Drug Substance	2
A Review on Analytical Methods of Anti-fungal Agents used for the Treatment of Onychomycosis	2
Spectroscopic Determination of Dissociation Constants of Some 4- nitrobenzaldehyde-4-substituted phenyl-1-carbonylhydrazones in Sodium Hydroxide Media	2
A Robust RP-HPLC Method for Simultaneous Quantification, Validation and Stability Studies on Vildagliptin (VILD), Dapagliflozin (DAPA) and Metformin Hydrochloride (METF) in its Combined Dosage Formula	2
Investigation of the Permeability of Antiretroviral Drugs Lamivudine and Valganciclovir via Single-Pass Intestinal Perfusion (SPIP) Method	2
A systematic and comprehensive review of the properties and synthesis of anticancer heterocyclic natural products	2
Comparison of ZIC-HILIC Columns for the Simultaneous Analysis of Antiviral Drugs in Dosage Forms by Hydrophilic Interaction Liquid Chromatography	2
An Update on Recently Developed Analytical and Bio-analytical Methods for Some Anticancer Drugs	2
Bioanalytical Method Development of Atenolol Enantiomers: Stereoselective Behavior in Rabbit Plasma by RP-UFLC Method	2
Development of a Suitable HPLC Method for the Analysis of Impurities in Clorprenaline and Bromhexine Capsules and Identification of Unknown Impurities by 2D LC-Q-TOF MS	2
Maraviroc Oral Disintegration Tablet: Analytical Design of Experiments (DoE) for Assessment and Comparison of In vitro Dissolution Profiles	2