Purinergic Signalling

Article	Citations
Some reflections after a long life in science	46
The impact of inosine on hippocampal synaptic transmission and plasticity involves the release of adenosine through equilibrative nucleoside transporters rather than the direct activation of adenosine	32
Characterization of purinergic signaling in tumor-infiltrating lymphocytes from lower- and high-grade gliomas	31
Hippocampal astrocytes relieve anxiogenic behavior by increasing, via the release of ATP, excitatory synaptic transmission in dentate gyrus granule cells	30
Electroacupuncture may alleviate diabetic neuropathic pain by inhibiting the microglia P2X4R and neuroinflammation	24
P2Y12 receptor antagonism inhibits proliferation, migration and leads to autophagy of glioblastoma cells	24
Role of the P2X7 receptor in breast cancer progression	23
Purinergic P2X7 receptor involves in anti-retinal photodamage effects of berberine	23
Neuroprotection of exercise: P2X4R and P2X7R regulate BDNF actions	22
Promoting glymphatic flow: A non-invasive strategy using 40 Hz light flickering	21
Moxibustion pre-treatment attenuates seizure severity during status epilepticus and counteracts the proconvulsant function of the purinergic P2X7 receptor	21
The exploration of active components of 701 Dieda Zhentong patch and analgesic properties on chronic constriction injury rats	21
Human plasmacytoid dendritic cells express the functional purinergic halo (CD39/CD73)	20
Correction to: A1R–A2AR heteromers coupled to Gs and Gi/0 proteins modulate GABA transport into astrocytes	19
P2X7 receptor promotes migration and invasion of non-small cell lung cancer A549 cells through the PI3K/Akt pathways	19
Diadenosine pentaphosphate regulates dendrite growth and number in cultured hippocampal neurons	17
ENTPD1 (CD39) and NT5E (CD73) expression in human medulloblastoma: an in silico analysis	16
Effects of nanoflubendazole and purinergic signaling modulation in overcoming neuroblastoma chemoresistance	16
Astrocytic adenosine A2B receptors: a crucial player in brain function	16
Macrophage P2Y6 receptor signalling as a key mediator and therapeutic target in atherosclerosis	16
Pharmacological interaction and immune response of purinergic receptors in therapeutic modulation	15
Electroacupuncture may alleviate inflammatory pain by downregulating the expression of P2Y14 receptor in the primary somatosensory cortex	15
Second meeting of the Australian and New Zealand Purine Club	14
Mono-ADP-ribosylation sites of human CD73 inhibit its adenosine-generating enzymatic activity	14
Purinergic receptors mediate endothelial dysfunction and participate in atherosclerosis	14

Editorial: purinergic signalling—perspectives from Australia and New Zealand	14
Purines help determine the gut’s sweet tooth	14
Inhibiting the P2Y13 receptor reduces IL-33 and HMGB1 lung concentrations and inflammatory cell infiltration in a murine model of asthma	14
Purinergic P2X3 receptors in the carotid body as new therapeutic targets for controlling heart failure	14
Synthesis of new non-natural l-glycosidic flavonoid derivatives and their evaluation as inhibitors of Trypanosoma cruzi ecto-nucleoside triphosphate diphosphohydrolase 1 (TcNTPDase1)	13
MicroRNA: Crucial modulator in purinergic signalling involved diseases	13
Preface to special issue “A tribute to Maria Teresa Miras-Portugal”	13
Pleiotropic effects of clopidogrel	13
Pharmacological characterization of P2Y receptor subtypes – an update	13
The P2Y2 receptor as a sensor of nucleotides and cell recruitment during inflammatory processes of the liver	13
May be adenosine an immuno-quorum-sensing signal?	12
P2 purinergic receptor dysregulation in urologic disease	12
Genetic polymorphisms of purinergic P2Y2 receptor were associated with the susceptibility to essential hypertension in Chinese postmenopausal women	11
Purinergic system in cancer stem cells	11
RETRACTED ARTICLE: Lysophosphatidylcholine induces adenosine release from macrophages via TRPM7-mediated mitochondrial activation	11
NPP1 and TNAP hydrolyze ATP synergistically during biomineralization	11
Crosstalk between P2Y receptors and cyclooxygenase activity in inflammation and tissue repair	10
Cutaneous melanoma and purinergic modulation by phenolic compounds	10
Ginsenosides enhance P2X7-dependent cytokine secretion from LPS-primed rodent macrophages	9
DUSP1/MKP-1 represents another piece in the P2X7R intracellular signaling puzzle in cerebellar cells: our last journey with Mª Teresa along the purinergic pathways of Eden	9
P2Y6 promoted pruning of FSTL1 nerves by cutaneous macrophages to reset pain threshold and cardiac function	9
Adenosine receptor signalling in Alzheimer’s disease	8
The anti-inflammatory effect of physical exercise on type 2 diabetes: the role of purinergic signaling	8
Mechanisms of ATP release in pain: role of pannexin and connexin channels	8
Partners in health and disease: pineal gland and purinergic signalling	8
P2Y11/IL-1 receptor crosstalk controls macrophage inflammation: a novel target for anti-inflammatory strategies?	8
Identification of novel proteins involved in P2X7-mediated signaling cascades	8
Anti-inflammatory and analgesic properties of Polyphyllin VI revealed by network pharmacology and RNA sequencing	8
Editorial—Translation of purinergic drugs into therapeutic use	7
T cell-derived adenosine regulates fibroblast IL-6 formation via A2B receptors in the infarcted heart	7
Correction to: The role of purinergic P2X3 receptors and endometriosis-associated hyperalgesia	7
Analgesic effect of electroacupuncture on bone cancer pain in rat model: the role of peripheral P2X3 receptor	7
P2 purinergic receptor expression and function in tumor-related immune cells	7
Fluorescent A2A and A3 adenosine receptor antagonists as flow cytometry probes	7
Heterologous expression and biochemical characterization of the recombinant nucleoside triphosphate diphosphohydrolase 2 (LbNTPDase2) from Leishmania (Viannia) braziliensis	7
Potential role of the P2X7 receptor in the proliferation of human diffused large B-cell lymphoma	7
P2Y11 receptor is a critical regulator of extracellular ATP-mediated premature senescence in lung fibroblasts: Implications of ER-Ca+2 release/mitochondrial ROS production signaling pathway	7
Antagonism of the ATP-gated P2X7 receptor inhibits the proliferation of hepatocellular carcinoma cells	6
Retraction Note: Modulation of the TGF-β1-induced epithelial to mesenchymal transition (EMT) mediated by P1 and P2 purine receptors in MDCK cells	6
Correction to: Purinoceptor: a novel target for hypertension	6
Role and recent progress of P2Y12 receptor in cancer development	6
In vivo phenotypic validation of adenosine receptor-dependent activity of non-adenosine drugs	6
Mechanosensitive release of ATP in the urinary bladder mucosa	6
Purinergic P2Y1 and P2Y12 receptors control enteric nervous system activity through neuro-glia-macrophage crosstalk	6
CD39 in the development and progression of pulmonary arterial hypertension	6
Ectonucleotidases as bridge between the ATP and adenosine world: reflections on Geoffrey Burnstock	5
EU COST Action CA21130 PRESTO ‘P2X receptors as therapeutic targets’ inaugural meeting report	5
The P2Y2 receptor: a new player in taste buds	5
Purinergic signaling in liver disease: calcium signaling and induction of inflammation	5
Transactivation of receptor tyrosine kinases by purinergic P2Y and adenosine receptors	5

The enzymatic degradation of ATP to adenosine by microglial CD39 regulates neurovascular coupling and metabolic supply to the brain	5
Gallic acid modulates purine metabolism and oxidative stress induced by ethanol exposure in zebrafish brain	5
Molecular mechanisms of extracellular-ATP-mediated colorectal cancer progression: Implication of purinergic receptors-mediated nucleocytoplasmic shuttling of HuR	5
Purinergic modulation of the immune response to infections	5
Announcement of changes to the Editorial Board	5
Therapeutic potential of P2X7 receptor in retinal diseases	4
ATP released from dying cancer cells stimulates P2X4 receptors and mTOR in their neighbors	4
A major role for adenosine A2A receptor in the interaction between astrocytes and myelinated neurons: possible implications for the therapy of neurodegenerative disorders	4
Screening herbal and natural product libraries to aid discovery of novel allosteric modulators of human P2X7	4
Purinoceptor: a novel target for hypertension	4
P2X receptors in the balance between inflammation and pathogen control in sepsis	4
Gene expression alterations of purinergic signaling components in obesity-associated intestinal low-grade inflammation in type 2 diabetes	4
Third meeting of the Australian and New Zealand Purine Club	4
Unexpected role of microglia and P2Y12 in the induction of and emergence from anesthesia	4
CD39 activities in the treated acupoints contributed to the analgesic mechanism of acupuncture on arthritis rats	4
The P2X7 receptor in leukemia: pathological mechanisms and therapeutic potential	4
The antidepressant-like effect of guanosine involves the modulation of adenosine A1 and A2A receptors	4
NT5E gene and CD38 protein as potential prognostic biomarkers for childhood B-acute lymphoblastic leukemia	4
Combined oral contraceptives alter ectonucleotidase and adenosine deaminase activities in peripheral blood cells	4
Burnstock oration — purinergic signalling in kidney transplantation	4
Adenosine signaling mediate pain transmission in the central nervous system	4
P2X7 receptor in macrophage polarization and its implications in neuroblastoma tumor behavior	3
P2Y14 receptors: a new target for treating ulcerative colitis	3
The P2X1 receptor as a therapeutic target	3
Schwann cells transplantation improves nerve injury and alleviates neuropathic pain in rats	3
P2X7 receptor involved in antitumor activity of atractylenolide I in human cervical cancer cells	3
Adenosine A2A receptor controls the gateway of the choroid plexus	3
Caffeine: a potential mechanism for anti-obesity	3
Differently expression of the metabotropic P2Y receptor family after hypoxia-induced seizures in neonates and seizure suppression via P2Y1 receptor agonism	3
Is the regulation by miRNAs of NTPDase1 and ecto-5’-nucleotidase genes involved with the different profiles of breast cancer subtypes?	3
Transcriptomic analysis reveals novel age-independent immunomodulatory proteins as a mode of cerebroprotection in P2X4 receptor knockout mice after ischemic stroke	3
Spinal cord astrocyte P2X7Rs mediate the inhibitory effect of electroacupuncture on visceral hypersensitivity of rat with irritable bowel syndrome	3
The impact of purine nucleosides on neuroplasticity in the adult brain	3
Hematopoietic stem cells on the crossroad between purinergic signaling and innate immunity	3
Long non-coding RNA MSTRG.81401 short hairpin RNA relieves diabetic neuropathic pain and behaviors of depression by inhibiting P2X4 receptor expression in type 2 diabetic rats	3
Rosmarinic acid modulates purinergic signaling and induces apoptosis in melanoma cells	3
Role of the extracellular ATP/pyrophosphate metabolism cycle in vascular calcification	3
The role of purinergic P2X3 receptors and endometriosis-associated hyperalgesia	3
Caffeine plus haloperidol reduces fatigue in an experimental model of Parkinson's disease – a prospective to A2AR-D2R heterodimer antagonism	3
Activation of P2X4 receptors in midbrain cerebrospinal fluid-contacting nucleus leads to mechanical hyperalgesia in chronic constriction injury rats	3
Caffeine reduces viability, induces apoptosis, inhibits migration and modulates the CD39/CD73 axis in metastatic cutaneous melanoma cells	3
A step-by-step protocol based on data mining to explore purinergic signaling in glioblastoma	3
Adenosine receptors and acute kidney injury: perspectives for future therapy	3
The role of purinergic signaling in acupuncture-mediated relief of neuropathic and inflammatory pain	3
ATP breakdown in plasma of children limits the antimicrobial effectiveness of their neutrophils	2
P2 X 7 receptor is a critical regulator of extracellular ATP-induced profibrotic genes expression in rat kidney: implication of transforming growth factor-β/Smad signaling pathway	2
Functional role of P2X7 purinergic receptor in cancer and cancer-related pain	2
P2Y12 receptor-mediated cyclooxygenase 2 (COX-2) expression enhances tumor cell progression in a mouse model of lymphoma	2
Cell cycle regulation by ADP and IGF-1 in cultured late developing glia progenitors of the avian retina	2
P2X7 receptor: the regulator of glioma tumor development and survival	2
First evidence of Tityus confluens Borelli, 1899 (Buthidae) venom altering purine metabolism in rat blood cells	2
ATP, an attractive target for the treatment of refractory chronic cough	2
Correction to: Regulation of TrkB receptor translocation to lipid rafts by adenosine A2A receptors and its functional implications for BDNF-induced regulation of synaptic plasticity	2
P2X7 and P2Y1 receptors in DRG mediate electroacupuncture to inhibit peripheral sensitization in rats with IBS visceral pain	2
P2X7 receptor is essential for ST36-attenuated cardiac fibrosis upon beta-adrenergic insult	2
SCH58261 effectively prevents the reduction in excitability of striatal MSNs in mice following 20 h of sleep deprivation	2
The P2X7 receptor is a target of p53 and regulates haematopoiesis following radiation-induced genotoxic stress	2
Publisher Correction to: Adenosine receptor signalling in Alzheimer’s disease	2
Breast cancer patients present pro-tumor biomarkers related to purinergic signaling and oxidative stress	2
Functional expression of the ATP-gated P2X7 receptor in human iPSC-derived astrocytes	2
Covalently Binding Adenosine A3 Receptor Agonist ICBM Irreversibly Reduces Voltage-Gated Ca2+ Currents in Dorsal Root Ganglion Neurons	2
ADP as a novel stimulus for NLRP3-inflammasome activation in mice fails to translate to humans	2
Involvement of purinergic signalling in the vasomotor response to hypochlorous acid in porcine coronary artery	2
P2 purinergic receptors regulate the progression of colorectal cancer	2
Metastasis and angiogenesis in cervical cancer: key aspects of purinergic signaling in platelets and possible therapeutic targets	2
Astrocytic P2X7 receptor regulates depressive-like behavioral reactions of mice in response to acute stressful stimulation	2
Modulation of osteoblast differentiation and function by the P2X4 receptor	2
Acute effects of guanosine or inosine in a porcine model of hemorrhagic shock	2
Species dependence of A3 adenosine receptor pharmacology and function	1
The circadian regulation of extracellular ATP	1
Novel synthesized ionizable lipid for LNP-mediated P2X7siRNA to inhibit migration and induce apoptosis of breast cancer cells	1
P2X7 receptor activation mediates superoxide dismutase 1 (SOD1) release from murine NSC-34 motor neurons	1
The P2X7R is a crucial target for Angiotensin II-induced myocardial ferroptosis and remodeling	1
Spinal P2X4 Receptors Involved in Visceral Hypersensitivity of Neonatal Maternal Separation Rats	1
P2Y12 receptor gene polymorphisms are associated with epilepsy	1
A new approach to psoriasis therapy: photoswitchable A3 adenosine receptor activation	1
Editorial: Purinergic signalling—a perspective from China (II)	1
Pharmacological differences between human and mouse P2X4 receptor explored using old and new tools	1
P2X3 receptors in the paraventricular hypothalamus: a specific target for visceral pain	1
Role of ecto-5’-nucleotidase in bladder function activity and smooth muscle contractility	1

A2B adenosine receptor signaling and regulation	1
The real-time detection of acupuncture-induced extracellular ATP mobilization in acupoints and exploration of its role in acupuncture analgesia	1
P2Y6R together with CYSLTR2 serves as endogenous receptor for long-chain ceramides in atherosclerosis	1
CD73 polymorphisms are associated with schizophrenia	1
Reprogramming the tumor microenvironment by targeting cytidine deaminase in pancreatic ductal adenocarcinoma tumors: implications for the role of P2Y6 receptors	1
Purinergic signaling in health: special issue of purines 2022 in Brazil	1
ATP release mediated by pannexin-3 is required for plasma cell survival via P2X4 receptors in bone marrow	1
Regulation of transcription factor function by purinergic signalling in cardiovascular diseases	1
Preclinical and clinical aspects of P2X receptors as a common route in different diseases: A meeting report	1
Editorial: Small molecules and biologics for future purinergic therapeutics	1
A2A receptors: a new target for immunotherapy resistance in prostate cancer	1
P2X7 receptors and pannexin1 hemichannels shape presynaptic transmission	1
Purinergic signaling in the peripheral vestibular system	1
Chemical biology-based approaches to study adenosine A2A − dopamine D2 receptor heteromers	1
The developmental journey of therapies targeting purine receptors: from basic science to clinical trials	1
Adenine at lower doses acts in the kidney as an aquaretic agent and prevents hyponatremia	1
Purines and purinergic receptors in primary tumors of the central nervous system	1
How selective antagonists and genetic modification have helped characterise the expression and functions of vascular P2Y receptors	1
Regulation of GABAergic neurotransmission by purinergic receptors in brain physiology and disease	1
Blockage of the adenosine A2B receptor prevents cardiac fibroblasts overgrowth in rats with pulmonary arterial hypertension	1
Molecular insights into P2X signalling cascades in acute kidney injury	1
Inhibition of P2X7 receptors by Lu AF27139 diminishes colonic hypersensitivity and CNS prostanoid levels in a rat model of visceral pain	1
Expanding the P2X7R toolbox: discovery of a novel Iodine-125 radioligand	1
Characterisation of P2Y receptor subtypes mediating vasodilation and vasoconstriction of rat pulmonary artery using selective antagonists	1
Correction to: P2 purinergic receptors regulate the progression of colorectal cancer	1
Retraction Note: Lysophosphatidylcholine induces adenosine release from macrophages via TRPM7-mediated mitochondrial activation	1
Electroacupuncture regulates the P2X7R-NLRP3 inflammatory cascade to relieve decreased sensation on ocular surface of type 2 diabetic rats with dry eye	1
Microglial purinergic signaling in Alzheimer’s disease	1
P2X7Rs: new therapeutic targets for osteoporosis	1
Effect of chronic maternal L-Glu intake during gestation and/or lactation on oxidative stress markers, AMPA Glu1 receptor and adenosine A1 signalling pathway from foetal and neonatal cerebellum	1
ENTPD1 (CD39) and NT5E (CD73) expression in human glioblastoma: an in silico analysis	1
Machine learning-aided search for ligands of P2Y6 and other P2Y receptors	1
Enlightening activation gating in P2X receptors	1
Functional role of adenosine via KATP channels in cerebral capillary endothelial cells and pericytes	1
Novel possibility for cutaneous melanoma treatment by means of rosmarinic acid action on purinergic signaling	1
P2X7-mediated alteration of membrane fluidity is associated with the late stages of age-related macular degeneration	1
Istradefylline modulates purinergic enzymes and reduces malignancy-associated factors in B16F10 melanoma cells	1
The striatum drives the ergogenic effects of caffeine	1