Purinergic Signalling

Article	Citations
Some reflections after a long life in science	34
Neuroprotection of exercise: P2X4R and P2X7R regulate BDNF actions	27
Purinergic P2X7 receptor involves in anti-retinal photodamage effects of berberine	27
Hippocampal astrocytes relieve anxiogenic behavior by increasing, via the release of ATP, excitatory synaptic transmission in dentate gyrus granule cells	27
Electroacupuncture may alleviate diabetic neuropathic pain by inhibiting the microglia P2X4R and neuroinflammation	26
Characterization of purinergic signaling in tumor-infiltrating lymphocytes from lower- and high-grade gliomas	25
The impact of inosine on hippocampal synaptic transmission and plasticity involves the release of adenosine through equilibrative nucleoside transporters rather than the direct activation of adenosine	23
Role of the P2X7 receptor in breast cancer progression	21
The potential role of adenosinergic pathway and methylxanthines in Parkinson’s disease: Blowing in the wind or not	20
P2Y12 receptor antagonism inhibits proliferation, migration and leads to autophagy of glioblastoma cells	20
The P2X7 receptor/NLRP3 inflammasome signaling axis in sepsis: molecular mechanisms, organ-specific pathophysiology, and emerging therapeutic strategies	19
The exploration of active components of 701 Dieda Zhentong patch and analgesic properties on chronic constriction injury rats	17
Human plasmacytoid dendritic cells express the functional purinergic halo (CD39/CD73)	17
Promoting glymphatic flow: A non-invasive strategy using 40 Hz light flickering	16
Guanosine contributes to rapid purinergic regulation of dopamine during ischemia	16
Moxibustion pre-treatment attenuates seizure severity during status epilepticus and counteracts the proconvulsant function of the purinergic P2X7 receptor	15
P2X7 receptor promotes migration and invasion of non-small cell lung cancer A549 cells through the PI3K/Akt pathways	15
Astrocytic adenosine A2B receptors: a crucial player in brain function	14
Macrophage P2Y6 receptor signalling as a key mediator and therapeutic target in atherosclerosis	14
Brilliant blue G enhances cardiac function and suppresses ventricular arrhythmias by attenuating inflammation and fibrosis after post-myocardial infarction in rats	14
ENTPD1 (CD39) and NT5E (CD73) expression in human medulloblastoma: an in silico analysis	14
Correction to: A1R–A2AR heteromers coupled to Gs and Gi/0 proteins modulate GABA transport into astrocytes	13
Diadenosine pentaphosphate regulates dendrite growth and number in cultured hippocampal neurons	12
Effects of nanoflubendazole and purinergic signaling modulation in overcoming neuroblastoma chemoresistance	12
Increased P2X7 level does not affect anxiety or stress-coping behavior in male mice	12

Pharmacological interaction and immune response of purinergic receptors in therapeutic modulation	12
Identification of the promoter region of the human P2RX7 gene	12
Electroacupuncture may alleviate inflammatory pain by downregulating the expression of P2Y14 receptor in the primary somatosensory cortex	11
The biphasic regulatory effect of adenosine A2B receptor in ischemic brain injury and its therapeutic potential	10
Functional role of peripheral P2X3 receptor expression in trigeminal ganglion neurons: a microarray-based evaluation of the antagonist effect of P2X3	10
Pharmacological characterization of P2Y receptor subtypes – an update	10
Editorial: purinergic signalling—perspectives from Australia and New Zealand	10
P2Y14 receptor activation and neutrophil signaling: linking inflammation to systemic pathophysiology	10
Purinergic P2X3 receptors in the carotid body as new therapeutic targets for controlling heart failure	10
The P2Y2 receptor as a sensor of nucleotides and cell recruitment during inflammatory processes of the liver	10
Pleiotropic effects of clopidogrel	10
The P2X4-P2X7 purinergic axis in alcohol-related liver disease: from fibrogenesis to immunotherapy resistance	9
Synthesis of new non-natural l-glycosidic flavonoid derivatives and their evaluation as inhibitors of Trypanosoma cruzi ecto-nucleoside triphosphate diphosphohydrolase 1 (TcNTPDase1)	9
Extracellular ATP induces the proinflammatory phenotype transition of MH7A cells by activating P2X7 receptor	9
P2 purinergic receptor dysregulation in urologic disease	9
Preface to special issue “A tribute to Maria Teresa Miras-Portugal”	9
Integrins α3 and α6 promote Th17 cell migration by activating the purinergic receptor P2X4	8
Cutaneous melanoma and purinergic modulation by phenolic compounds	8
RETRACTED ARTICLE: Lysophosphatidylcholine induces adenosine release from macrophages via TRPM7-mediated mitochondrial activation	8
Purinergic system in cancer stem cells	8
Expression of the P2X1 receptor remains in the type II spiral ganglion neurons in the mature rat cochlea	8
P2Y11/IL-1 receptor crosstalk controls macrophage inflammation: a novel target for anti-inflammatory strategies?	8
NPP1 and TNAP hydrolyze ATP synergistically during biomineralization	8
P2Y6 receptor in the superior cervical ganglion: a key mediator of post-myocardial ischemic sympathetic hyperexcitability via NF-κB mediated neuroinflammation	7
Ginsenosides enhance P2X7-dependent cytokine secretion from LPS-primed rodent macrophages	7
Anti-inflammatory and analgesic properties of Polyphyllin VI revealed by network pharmacology and RNA sequencing	7
Genetic polymorphisms of purinergic P2Y2 receptor were associated with the susceptibility to essential hypertension in Chinese postmenopausal women	7
Crosstalk between P2Y receptors and cyclooxygenase activity in inflammation and tissue repair	7
Partners in health and disease: pineal gland and purinergic signalling	7
The anti-inflammatory effect of physical exercise on type 2 diabetes: the role of purinergic signaling	7
DUSP1/MKP-1 represents another piece in the P2X7R intracellular signaling puzzle in cerebellar cells: our last journey with Mª Teresa along the purinergic pathways of Eden	7
P2Y11 receptor is a critical regulator of extracellular ATP-mediated premature senescence in lung fibroblasts: Implications of ER-Ca+2 release/mitochondrial ROS production signaling pathway	7
Adenosine receptor signalling in Alzheimer’s disease	7
P2Y6 promoted pruning of FSTL1 nerves by cutaneous macrophages to reset pain threshold and cardiac function	7
Potential role of the P2X7 receptor in the proliferation of human diffused large B-cell lymphoma	6
Correction to: The role of purinergic P2X3 receptors and endometriosis-associated hyperalgesia	6
Role and recent progress of P2Y12 receptor in cancer development	6
Identification of novel proteins involved in P2X7-mediated signaling cascades	6
Heterologous expression and biochemical characterization of the recombinant nucleoside triphosphate diphosphohydrolase 2 (LbNTPDase2) from Leishmania (Viannia) braziliensis	6
T cell-derived adenosine regulates fibroblast IL-6 formation via A2B receptors in the infarcted heart	6
Fluorescent A2A and A3 adenosine receptor antagonists as flow cytometry probes	6
Editorial—Translation of purinergic drugs into therapeutic use	6
ATP and major affective disorders: the involvement of P2X receptors in pathophysiology	6
Purinergic P2Y1 and P2Y12 receptors control enteric nervous system activity through neuro-glia-macrophage crosstalk	6
Mixed circuit training as a non-pharmacological strategy to improve platelet function and oxidative balance in type 2 diabetes: role of purinergic signaling	5
Correction to: Purinoceptor: a novel target for hypertension	5
Purinergic signaling in liver disease: calcium signaling and induction of inflammation	5
The enzymatic degradation of ATP to adenosine by microglial CD39 regulates neurovascular coupling and metabolic supply to the brain	5
Molecular mechanisms of extracellular-ATP-mediated colorectal cancer progression: Implication of purinergic receptors-mediated nucleocytoplasmic shuttling of HuR	5
Announcement of changes to the Editorial Board	5

Antagonism of the ATP-gated P2X7 receptor inhibits the proliferation of hepatocellular carcinoma cells	5
Retraction Note: Modulation of the TGF-β1-induced epithelial to mesenchymal transition (EMT) mediated by P1 and P2 purine receptors in MDCK cells	5
P2 purinergic receptor expression and function in tumor-related immune cells	5
Phenolic compounds and chemotherapeutic agents differentially regulate P2X receptor subtypes in malignant melanoma	5
EU COST Action CA21130 PRESTO ‘P2X receptors as therapeutic targets’ inaugural meeting report	5
Light flickering with 40 Hz causes analgesia via activation of a retina-amygdala pathway and the local release of adenosine	5
CD39 in the development and progression of pulmonary arterial hypertension	5
In vivo phenotypic validation of adenosine receptor-dependent activity of non-adenosine drugs	5
Gallic acid modulates purine metabolism and oxidative stress induced by ethanol exposure in zebrafish brain	5
Host-directed therapeutic strategies against apicomplexan parasites: targeting purinergic P2 receptors	5
Mechanosensitive release of ATP in the urinary bladder mucosa	5
Therapeutic potential of P2X7 receptor in retinal diseases	4
Screening herbal and natural product libraries to aid discovery of novel allosteric modulators of human P2X7	4
Gene expression alterations of purinergic signaling components in obesity-associated intestinal low-grade inflammation in type 2 diabetes	4
ATP released from dying cancer cells stimulates P2X4 receptors and mTOR in their neighbors	4
The P2X1 receptor as a therapeutic target	4
Transactivation of receptor tyrosine kinases by purinergic P2Y and adenosine receptors	4
Combined oral contraceptives alter ectonucleotidase and adenosine deaminase activities in peripheral blood cells	4
Abnormal purinergic signaling contributes to development of renal cysts in autosomal dominant polycystic kidney disease	4
Turning failure into success: how artificial intelligence can help personalize therapies and re-use patient data	4
Latest advances on the role of P2X Receptors in colorectal inflammation and cancer	4
Third meeting of the Australian and New Zealand Purine Club	4
CD39 activities in the treated acupoints contributed to the analgesic mechanism of acupuncture on arthritis rats	4
The P2X7 receptor in leukemia: pathological mechanisms and therapeutic potential	4
Unexpected role of microglia and P2Y12 in the induction of and emergence from anesthesia	4
The antidepressant-like effect of guanosine involves the modulation of adenosine A1 and A2A receptors	4
Acute effects of a single electroacupuncture session on purinergic signaling and inflammatory markers in patients with chronic nonspecific low back pain: a pilot study	4
The P2Y2 receptor: a new player in taste buds	4
Caffeine plus haloperidol reduces fatigue in an experimental model of Parkinson's disease – a prospective to A2AR-D2R heterodimer antagonism	4
Differently expression of the metabotropic P2Y receptor family after hypoxia-induced seizures in neonates and seizure suppression via P2Y1 receptor agonism	3
Activation of P2X4 receptors in midbrain cerebrospinal fluid-contacting nucleus leads to mechanical hyperalgesia in chronic constriction injury rats	3
The impact of purine nucleosides on neuroplasticity in the adult brain	3
P2Y14 receptors: a new target for treating ulcerative colitis	3
Functional role of P2X7 purinergic receptor in cancer and cancer-related pain	3
P2X7 receptor is essential for ST36-attenuated cardiac fibrosis upon beta-adrenergic insult	3
The role and therapeutic potential of purinergic signaling pathway in metabolic syndrome-related atherosclerosis	3
P2 X 7 receptor is a critical regulator of extracellular ATP-induced profibrotic genes expression in rat kidney: implication of transforming growth factor-β/Smad signaling pathway	3
A step-by-step protocol based on data mining to explore purinergic signaling in glioblastoma	3
The role of purinergic P2X3 receptors and endometriosis-associated hyperalgesia	3
Schwann cells transplantation improves nerve injury and alleviates neuropathic pain in rats	3
The role of purinergic signaling in acupuncture-mediated relief of neuropathic and inflammatory pain	3
Adenosine receptors and acute kidney injury: perspectives for future therapy	3
Caffeine: a potential mechanism for anti-obesity	3
P2X7 and P2Y1 receptors in DRG mediate electroacupuncture to inhibit peripheral sensitization in rats with IBS visceral pain	3
ADP as a novel stimulus for NLRP3-inflammasome activation in mice fails to translate to humans	3
Rosmarinic acid modulates purinergic signaling and induces apoptosis in melanoma cells	3
P2X7 receptor in macrophage polarization and its implications in neuroblastoma tumor behavior	3
Caffeine reduces viability, induces apoptosis, inhibits migration and modulates the CD39/CD73 axis in metastatic cutaneous melanoma cells	3
Hematopoietic stem cells on the crossroad between purinergic signaling and innate immunity	3
Transcriptomic analysis reveals novel age-independent immunomodulatory proteins as a mode of cerebroprotection in P2X4 receptor knockout mice after ischemic stroke	3
The purinergic signaling interfaces in breast cancer angiogenesis	3
Involvement of purinergic signalling in the vasomotor response to hypochlorous acid in porcine coronary artery	3
P2Y12 receptor-mediated cyclooxygenase 2 (COX-2) expression enhances tumor cell progression in a mouse model of lymphoma	3
CD73 polymorphisms are associated with schizophrenia	2
The analgesic effect of electroacupuncture in alleviating paclitaxel-induced peripheral neuropathic pain and its possible mechanism relates to TLR4/P2X7-NLRP3 signaling pathway	2
Functional expression of the ATP-gated P2X7 receptor in human iPSC-derived astrocytes	2
Metastasis and angiogenesis in cervical cancer: key aspects of purinergic signaling in platelets and possible therapeutic targets	2
ATP breakdown in plasma of children limits the antimicrobial effectiveness of their neutrophils	2
Cell cycle regulation by ADP and IGF-1 in cultured late developing glia progenitors of the avian retina	2
Publisher Correction to: Adenosine receptor signalling in Alzheimer’s disease	2
Spinal P2X4 Receptors Involved in Visceral Hypersensitivity of Neonatal Maternal Separation Rats	2
Preclinical and clinical aspects of P2X receptors as a common route in different diseases: A meeting report	2
Role of ecto-5’-nucleotidase in bladder function activity and smooth muscle contractility	2
Acute effects of guanosine or inosine in a porcine model of hemorrhagic shock	2
Retraction Note: Lysophosphatidylcholine induces adenosine release from macrophages via TRPM7-mediated mitochondrial activation	2
Covalently Binding Adenosine A3 Receptor Agonist ICBM Irreversibly Reduces Voltage-Gated Ca2+ Currents in Dorsal Root Ganglion Neurons	2
First evidence of Tityus confluens Borelli, 1899 (Buthidae) venom altering purine metabolism in rat blood cells	2
Capsaicin suppresses LPS-induced inflammatory responses via NLRP3/CASP-1/IL-1β axis and purinergic pathways in BV-2 microglial cells	2
Astrocytic P2X7 receptor regulates depressive-like behavioral reactions of mice in response to acute stressful stimulation	2
Electroacupuncture regulates the P2X7R-NLRP3 inflammatory cascade to relieve decreased sensation on ocular surface of type 2 diabetic rats with dry eye	2
Editorial: Small molecules and biologics for future purinergic therapeutics	2
Positive allosteric modulator activity of ginsenosides is restricted to P2X7 and P2X4 receptors	2
Istradefylline modulates purinergic enzymes and reduces malignancy-associated factors in B16F10 melanoma cells	2
A2A receptors: a new target for immunotherapy resistance in prostate cancer	2
ATP, an attractive target for the treatment of refractory chronic cough	2
Breast cancer patients present pro-tumor biomarkers related to purinergic signaling and oxidative stress	2
P2 purinergic receptors regulate the progression of colorectal cancer	2
SCH58261 effectively prevents the reduction in excitability of striatal MSNs in mice following 20 h of sleep deprivation	2
Tumor growth inhibitory activity of the P2X7 receptor antagonist AZ10606120 in two cell lines of human glioblastoma	2
Correction to: Regulation of TrkB receptor translocation to lipid rafts by adenosine A2A receptors and its functional implications for BDNF-induced regulation of synaptic plasticity	2

Modulation of osteoblast differentiation and function by the P2X4 receptor	2
Inhibition of P2X7 receptors by Lu AF27139 diminishes colonic hypersensitivity and CNS prostanoid levels in a rat model of visceral pain	2
Blockage of the adenosine A2B receptor prevents cardiac fibroblasts overgrowth in rats with pulmonary arterial hypertension	2