Purinergic Signalling

Article	Citations
Some reflections after a long life in science	45
Hippocampal astrocytes relieve anxiogenic behavior by increasing, via the release of ATP, excitatory synaptic transmission in dentate gyrus granule cells	36
Substrate binding modes of purine and pyrimidine nucleotides to human ecto-5′-nucleotidase (CD73) and inhibition by their bisphosphonic acid derivatives	31
Electroacupuncture may alleviate diabetic neuropathic pain by inhibiting the microglia P2X4R and neuroinflammation	30
Role of the P2X7 receptor in breast cancer progression	29
Purinergic P2X7 receptor involves in anti-retinal photodamage effects of berberine	26
P2Y12 receptor antagonism inhibits proliferation, migration and leads to autophagy of glioblastoma cells	22
Neuroprotection of exercise: P2X4R and P2X7R regulate BDNF actions	22
Characterization of purinergic signaling in tumor-infiltrating lymphocytes from lower- and high-grade gliomas	20
Moxibustion pre-treatment attenuates seizure severity during status epilepticus and counteracts the proconvulsant function of the purinergic P2X7 receptor	19
The impact of inosine on hippocampal synaptic transmission and plasticity involves the release of adenosine through equilibrative nucleoside transporters rather than the direct activation of adenosine	19
Promoting glymphatic flow: A non-invasive strategy using 40 Hz light flickering	19
UTP is a regulator of in vitro and in vivo angiogenic properties of cardiac adipose–derived stem cells	18
Human plasmacytoid dendritic cells express the functional purinergic halo (CD39/CD73)	17
The exploration of active components of 701 Dieda Zhentong patch and analgesic properties on chronic constriction injury rats	17
P2X7 receptor promotes migration and invasion of non-small cell lung cancer A549 cells through the PI3K/Akt pathways	17
Correction to: A1R–A2AR heteromers coupled to Gs and Gi/0 proteins modulate GABA transport into astrocytes	15
Diadenosine pentaphosphate regulates dendrite growth and number in cultured hippocampal neurons	15
Electroacupuncture may alleviate inflammatory pain by downregulating the expression of P2Y14 receptor in the primary somatosensory cortex	15
ENTPD1 (CD39) and NT5E (CD73) expression in human medulloblastoma: an in silico analysis	14
Effects of nanoflubendazole and purinergic signaling modulation in overcoming neuroblastoma chemoresistance	14
Astrocytic adenosine A2B receptors: a crucial player in brain function	14
Pharmacological interaction and immune response of purinergic receptors in therapeutic modulation	14
Purinergic receptors mediate endothelial dysfunction and participate in atherosclerosis	13
Macrophage P2Y6 receptor signalling as a key mediator and therapeutic target in atherosclerosis	13

Editorial: purinergic signalling—perspectives from Australia and New Zealand	13
Purines help determine the gut’s sweet tooth	12
Second meeting of the Australian and New Zealand Purine Club	12
Purinergic P2X3 receptors in the carotid body as new therapeutic targets for controlling heart failure	12
The P2Y2 receptor as a sensor of nucleotides and cell recruitment during inflammatory processes of the liver	12
Inhibiting the P2Y13 receptor reduces IL-33 and HMGB1 lung concentrations and inflammatory cell infiltration in a murine model of asthma	12
MicroRNA: Crucial modulator in purinergic signalling involved diseases	11
Preface to special issue “A tribute to Maria Teresa Miras-Portugal”	11
Pharmacological characterization of P2Y receptor subtypes – an update	11
Pleiotropic effects of clopidogrel	11
NPP1 and TNAP hydrolyze ATP synergistically during biomineralization	11
Mono-ADP-ribosylation sites of human CD73 inhibit its adenosine-generating enzymatic activity	11
May be adenosine an immuno-quorum-sensing signal?	11
Purinergic ATP triggers moxibustion-induced local anti-nociceptive effect on inflammatory pain model	11
Purinergic system in cancer stem cells	10
Synthesis of new non-natural l-glycosidic flavonoid derivatives and their evaluation as inhibitors of Trypanosoma cruzi ecto-nucleoside triphosphate diphosphohydrolase 1 (TcNTPDase1)	10
P2 purinergic receptor dysregulation in urologic disease	10
Genetic polymorphisms of purinergic P2Y2 receptor were associated with the susceptibility to essential hypertension in Chinese postmenopausal women	10
Pharmacological characterization of DPTN and other selective A3 adenosine receptor antagonists	10
RETRACTED ARTICLE: Lysophosphatidylcholine induces adenosine release from macrophages via TRPM7-mediated mitochondrial activation	9
The anti-inflammatory effect of physical exercise on type 2 diabetes: the role of purinergic signaling	9
P2Y6 promoted pruning of FSTL1 nerves by cutaneous macrophages to reset pain threshold and cardiac function	9
Cutaneous melanoma and purinergic modulation by phenolic compounds	9
P2Y11/IL-1 receptor crosstalk controls macrophage inflammation: a novel target for anti-inflammatory strategies?	9
DUSP1/MKP-1 represents another piece in the P2X7R intracellular signaling puzzle in cerebellar cells: our last journey with Mª Teresa along the purinergic pathways of Eden	8
Anti-inflammatory and analgesic properties of Polyphyllin VI revealed by network pharmacology and RNA sequencing	8
The role of Pannexin-1 channels and extracellular ATP in the pathogenesis of the human immunodeficiency virus	8
Mechanisms of ATP release in pain: role of pannexin and connexin channels	8
Ginsenosides enhance P2X7-dependent cytokine secretion from LPS-primed rodent macrophages	8
Crosstalk between P2Y receptors and cyclooxygenase activity in inflammation and tissue repair	8
Adenosine receptor signalling in Alzheimer’s disease	8
Heterologous expression and biochemical characterization of the recombinant nucleoside triphosphate diphosphohydrolase 2 (LbNTPDase2) from Leishmania (Viannia) braziliensis	7
P2Y11 receptor is a critical regulator of extracellular ATP-mediated premature senescence in lung fibroblasts: Implications of ER-Ca+2 release/mitochondrial ROS production signaling pathway	7
Identification of novel proteins involved in P2X7-mediated signaling cascades	7
Potential role of the P2X7 receptor in the proliferation of human diffused large B-cell lymphoma	7
Fluorescent A2A and A3 adenosine receptor antagonists as flow cytometry probes	7
Partners in health and disease: pineal gland and purinergic signalling	7
Editorial—Translation of purinergic drugs into therapeutic use	7
Correction to: The role of purinergic P2X3 receptors and endometriosis-associated hyperalgesia	7
Analgesic effect of electroacupuncture on bone cancer pain in rat model: the role of peripheral P2X3 receptor	6
Antagonism of the ATP-gated P2X7 receptor inhibits the proliferation of hepatocellular carcinoma cells	6
Retraction Note: Modulation of the TGF-β1-induced epithelial to mesenchymal transition (EMT) mediated by P1 and P2 purine receptors in MDCK cells	6
Quinacrine is not a vital fluorescent probe for vesicular ATP storage	6
Purinergic P2Y1 and P2Y12 receptors control enteric nervous system activity through neuro-glia-macrophage crosstalk	6
Role and recent progress of P2Y12 receptor in cancer development	6
T cell-derived adenosine regulates fibroblast IL-6 formation via A2B receptors in the infarcted heart	6
P2 purinergic receptor expression and function in tumor-related immune cells	6
CD39 in the development and progression of pulmonary arterial hypertension	5
Molecular mechanisms of extracellular-ATP-mediated colorectal cancer progression: Implication of purinergic receptors-mediated nucleocytoplasmic shuttling of HuR	5
EU COST Action CA21130 PRESTO ‘P2X receptors as therapeutic targets’ inaugural meeting report	5

The enzymatic degradation of ATP to adenosine by microglial CD39 regulates neurovascular coupling and metabolic supply to the brain	5
Correction to: Purinoceptor: a novel target for hypertension	5
Purinergic signaling in liver disease: calcium signaling and induction of inflammation	5
Announcement of changes to the Editorial Board	5
Purinergic signaling as a new mechanism underlying physical exercise benefits: a narrative review	5
In vivo phenotypic validation of adenosine receptor-dependent activity of non-adenosine drugs	5
Gallic acid modulates purine metabolism and oxidative stress induced by ethanol exposure in zebrafish brain	5
Mechanosensitive release of ATP in the urinary bladder mucosa	5
The P2Y2 receptor: a new player in taste buds	5
Ectonucleotidases as bridge between the ATP and adenosine world: reflections on Geoffrey Burnstock	5
P2X receptors in the balance between inflammation and pathogen control in sepsis	4
CD39 activities in the treated acupoints contributed to the analgesic mechanism of acupuncture on arthritis rats	4
Burnstock oration — purinergic signalling in kidney transplantation	4
Purinoceptor: a novel target for hypertension	4
ATP released from dying cancer cells stimulates P2X4 receptors and mTOR in their neighbors	4
Unexpected role of microglia and P2Y12 in the induction of and emergence from anesthesia	4
Purinergic modulation of the immune response to infections	4
Screening herbal and natural product libraries to aid discovery of novel allosteric modulators of human P2X7	4
Transactivation of receptor tyrosine kinases by purinergic P2Y and adenosine receptors	4
The antidepressant-like effect of guanosine involves the modulation of adenosine A1 and A2A receptors	4
Therapeutic potential of P2X7 receptor in retinal diseases	4
Purinergic signaling: a potential therapeutic target for depression and chronic pain	4
Adenosine signaling mediate pain transmission in the central nervous system	4
Combined oral contraceptives alter ectonucleotidase and adenosine deaminase activities in peripheral blood cells	4
Gene expression alterations of purinergic signaling components in obesity-associated intestinal low-grade inflammation in type 2 diabetes	4
A major role for adenosine A2A receptor in the interaction between astrocytes and myelinated neurons: possible implications for the therapy of neurodegenerative disorders	3
Caffeine plus haloperidol reduces fatigue in an experimental model of Parkinson's disease – a prospective to A2AR-D2R heterodimer antagonism	3
P2Y14 receptors: a new target for treating ulcerative colitis	3
To inhibit or to boost the ATP/P2RX7 pathway to fight cancer—that is the question	3
The role of purinergic P2X3 receptors and endometriosis-associated hyperalgesia	3
The impact of purine nucleosides on neuroplasticity in the adult brain	3
NT5E gene and CD38 protein as potential prognostic biomarkers for childhood B-acute lymphoblastic leukemia	3
Spinal cord astrocyte P2X7Rs mediate the inhibitory effect of electroacupuncture on visceral hypersensitivity of rat with irritable bowel syndrome	3
P2X7 receptor in macrophage polarization and its implications in neuroblastoma tumor behavior	3
Is the regulation by miRNAs of NTPDase1 and ecto-5’-nucleotidase genes involved with the different profiles of breast cancer subtypes?	3
The role of purinergic signaling in acupuncture-mediated relief of neuropathic and inflammatory pain	3
Third meeting of the Australian and New Zealand Purine Club	3
Schwann cells transplantation improves nerve injury and alleviates neuropathic pain in rats	3
The P2X1 receptor as a therapeutic target	3
Activation of P2X4 receptors in midbrain cerebrospinal fluid-contacting nucleus leads to mechanical hyperalgesia in chronic constriction injury rats	3
Caffeine reduces viability, induces apoptosis, inhibits migration and modulates the CD39/CD73 axis in metastatic cutaneous melanoma cells	3
Transcriptomic analysis reveals novel age-independent immunomodulatory proteins as a mode of cerebroprotection in P2X4 receptor knockout mice after ischemic stroke	3
P2X7 receptor is essential for ST36-attenuated cardiac fibrosis upon beta-adrenergic insult	2
Long non-coding RNA MSTRG.81401 short hairpin RNA relieves diabetic neuropathic pain and behaviors of depression by inhibiting P2X4 receptor expression in type 2 diabetic rats	2
A step-by-step protocol based on data mining to explore purinergic signaling in glioblastoma	2
Differently expression of the metabotropic P2Y receptor family after hypoxia-induced seizures in neonates and seizure suppression via P2Y1 receptor agonism	2
P2X7 receptor involved in antitumor activity of atractylenolide I in human cervical cancer cells	2
ADP as a novel stimulus for NLRP3-inflammasome activation in mice fails to translate to humans	2
ATP breakdown in plasma of children limits the antimicrobial effectiveness of their neutrophils	2
Metastasis and angiogenesis in cervical cancer: key aspects of purinergic signaling in platelets and possible therapeutic targets	2
Covalently Binding Adenosine A3 Receptor Agonist ICBM Irreversibly Reduces Voltage-Gated Ca2+ Currents in Dorsal Root Ganglion Neurons	2
Involvement of purinergic signalling in the vasomotor response to hypochlorous acid in porcine coronary artery	2
Caffeine: a potential mechanism for anti-obesity	2
Role of the extracellular ATP/pyrophosphate metabolism cycle in vascular calcification	2
Hematopoietic stem cells on the crossroad between purinergic signaling and innate immunity	2
P2 X 7 receptor is a critical regulator of extracellular ATP-induced profibrotic genes expression in rat kidney: implication of transforming growth factor-β/Smad signaling pathway	2
Publisher Correction to: Adenosine receptor signalling in Alzheimer’s disease	2
P2 purinergic receptors regulate the progression of colorectal cancer	2
Correction to: Regulation of TrkB receptor translocation to lipid rafts by adenosine A2A receptors and its functional implications for BDNF-induced regulation of synaptic plasticity	2
Astrocytic P2X7 receptor regulates depressive-like behavioral reactions of mice in response to acute stressful stimulation	2
Adenosine A2A receptor controls the gateway of the choroid plexus	2
Functional role of P2X7 purinergic receptor in cancer and cancer-related pain	2
Rosmarinic acid modulates purinergic signaling and induces apoptosis in melanoma cells	2
P2X7 and P2Y1 receptors in DRG mediate electroacupuncture to inhibit peripheral sensitization in rats with IBS visceral pain	2
P2Y12 receptor-mediated cyclooxygenase 2 (COX-2) expression enhances tumor cell progression in a mouse model of lymphoma	2
Cell cycle regulation by ADP and IGF-1 in cultured late developing glia progenitors of the avian retina	2
The P2X7 receptor is a target of p53 and regulates haematopoiesis following radiation-induced genotoxic stress	2
SCH58261 effectively prevents the reduction in excitability of striatal MSNs in mice following 20 h of sleep deprivation	2
P2X7 receptor: the regulator of glioma tumor development and survival	2
ATP transporters in the joints	1
Inhibition of P2X7 receptors by Lu AF27139 diminishes colonic hypersensitivity and CNS prostanoid levels in a rat model of visceral pain	1
The real-time detection of acupuncture-induced extracellular ATP mobilization in acupoints and exploration of its role in acupuncture analgesia	1
Electroacupuncture regulates the P2X7R-NLRP3 inflammatory cascade to relieve decreased sensation on ocular surface of type 2 diabetic rats with dry eye	1
P2Y12 receptor gene polymorphisms are associated with epilepsy	1
A2A receptors: a new target for immunotherapy resistance in prostate cancer	1
The P2X7R is a crucial target for Angiotensin II-induced myocardial ferroptosis and remodeling	1
Effect of chronic maternal L-Glu intake during gestation and/or lactation on oxidative stress markers, AMPA Glu1 receptor and adenosine A1 signalling pathway from foetal and neonatal cerebellum	1
The developmental journey of therapies targeting purine receptors: from basic science to clinical trials	1
Regulation of GABAergic neurotransmission by purinergic receptors in brain physiology and disease	1
Istradefylline modulates purinergic enzymes and reduces malignancy-associated factors in B16F10 melanoma cells	1

P2Y6R together with CYSLTR2 serves as endogenous receptor for long-chain ceramides in atherosclerosis	1
Spinal P2X4 Receptors Involved in Visceral Hypersensitivity of Neonatal Maternal Separation Rats	1
The striatum drives the ergogenic effects of caffeine	1
Chemical biology-based approaches to study adenosine A2A − dopamine D2 receptor heteromers	1
Correction to: P2 purinergic receptors regulate the progression of colorectal cancer	1
Novel possibility for cutaneous melanoma treatment by means of rosmarinic acid action on purinergic signaling	1
Species dependence of A3 adenosine receptor pharmacology and function	1
Acute effects of guanosine or inosine in a porcine model of hemorrhagic shock	1
Preclinical and clinical aspects of P2X receptors as a common route in different diseases: A meeting report	1
Characterisation of P2Y receptor subtypes mediating vasodilation and vasoconstriction of rat pulmonary artery using selective antagonists	1
ATP, an attractive target for the treatment of refractory chronic cough	1
Modulation of osteoblast differentiation and function by the P2X4 receptor	1
Purinergic signaling in the peripheral vestibular system	1
Purines and purinergic receptors in primary tumors of the central nervous system	1
Machine learning-aided search for ligands of P2Y6 and other P2Y receptors	1
Functional role of adenosine via KATP channels in cerebral capillary endothelial cells and pericytes	1
Expanding the P2X7R toolbox: discovery of a novel Iodine-125 radioligand	1
Blockage of the adenosine A2B receptor prevents cardiac fibroblasts overgrowth in rats with pulmonary arterial hypertension	1
Molecular insights into P2X signalling cascades in acute kidney injury	1
P2X7 receptors and pannexin1 hemichannels shape presynaptic transmission	1
Enlightening activation gating in P2X receptors	1
A new approach to psoriasis therapy: photoswitchable A3 adenosine receptor activation	1
ATP release mediated by pannexin-3 is required for plasma cell survival via P2X4 receptors in bone marrow	1
P2X7Rs: new therapeutic targets for osteoporosis	1
The circadian regulation of extracellular ATP	1
Retraction Note: Lysophosphatidylcholine induces adenosine release from macrophages via TRPM7-mediated mitochondrial activation	1
CD73 polymorphisms are associated with schizophrenia	1
Reprogramming the tumor microenvironment by targeting cytidine deaminase in pancreatic ductal adenocarcinoma tumors: implications for the role of P2Y6 receptors	1
Functional expression of the ATP-gated P2X7 receptor in human iPSC-derived astrocytes	1
Microglial purinergic signaling in Alzheimer’s disease	1
First evidence of Tityus confluens Borelli, 1899 (Buthidae) venom altering purine metabolism in rat blood cells	1
P2X3 receptors in the paraventricular hypothalamus: a specific target for visceral pain	1
ENTPD1 (CD39) and NT5E (CD73) expression in human glioblastoma: an in silico analysis	1
A2B adenosine receptor signaling and regulation	1
P2X7 receptor activation mediates superoxide dismutase 1 (SOD1) release from murine NSC-34 motor neurons	1
P2X7-mediated alteration of membrane fluidity is associated with the late stages of age-related macular degeneration	1
Role of ecto-5’-nucleotidase in bladder function activity and smooth muscle contractility	1
Regulation of transcription factor function by purinergic signalling in cardiovascular diseases	1
Pharmacological differences between human and mouse P2X4 receptor explored using old and new tools	1
Novel synthesized ionizable lipid for LNP-mediated P2X7siRNA to inhibit migration and induce apoptosis of breast cancer cells	1
How selective antagonists and genetic modification have helped characterise the expression and functions of vascular P2Y receptors	1
Purinergic signaling in health: special issue of purines 2022 in Brazil	1
Editorial: Small molecules and biologics for future purinergic therapeutics	1