OOIR: Observatory of International Research

Papers

(The median citation count of Purinergic Signalling is 2. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2022-08-01 to 2026-08-01.)

Article	Citations
Some reflections after a long life in science	29
Purinergic P2X7 receptor involves in anti-retinal photodamage effects of berberine	27
Characterization of purinergic signaling in tumor-infiltrating lymphocytes from lower- and high-grade gliomas	27
The impact of inosine on hippocampal synaptic transmission and plasticity involves the release of adenosine through equilibrative nucleoside transporters rather than the direct activation of adenosine	22
Role of the P2X7 receptor in breast cancer progression	20
Hippocampal astrocytes relieve anxiogenic behavior by increasing, via the release of ATP, excitatory synaptic transmission in dentate gyrus granule cells	19
Electroacupuncture may alleviate diabetic neuropathic pain by inhibiting the microglia P2X4R and neuroinflammation	18
P2Y12 receptor antagonism inhibits proliferation, migration and leads to autophagy of glioblastoma cells	18
The potential role of adenosinergic pathway and methylxanthines in Parkinson’s disease: Blowing in the wind or not	17
The P2X7 receptor/NLRP3 inflammasome signaling axis in sepsis: molecular mechanisms, organ-specific pathophysiology, and emerging therapeutic strategies	16
Promoting glymphatic flow: A non-invasive strategy using 40 Hz light flickering	14
Brilliant blue G enhances cardiac function and suppresses ventricular arrhythmias by attenuating inflammation and fibrosis after post-myocardial infarction in rats	14
Human plasmacytoid dendritic cells express the functional purinergic halo (CD39/CD73)	14
Moxibustion pre-treatment attenuates seizure severity during status epilepticus and counteracts the proconvulsant function of the purinergic P2X7 receptor	14
The exploration of active components of 701 Dieda Zhentong patch and analgesic properties on chronic constriction injury rats	14
P2X7 receptor promotes migration and invasion of non-small cell lung cancer A549 cells through the PI3K/Akt pathways	13
Guanosine contributes to rapid purinergic regulation of dopamine during ischemia	13
Astrocytic adenosine A2B receptors: a crucial player in brain function	12
ENTPD1 (CD39) and NT5E (CD73) expression in human medulloblastoma: an in silico analysis	12
Is adenosine signalling entering the precision medicine era? From receptor pharmacology to patient stratification	12
The biphasic regulatory effect of adenosine A2B receptor in ischemic brain injury and its therapeutic potential	11
Pharmacological interaction and immune response of purinergic receptors in therapeutic modulation	11
Effects of nanoflubendazole and purinergic signaling modulation in overcoming neuroblastoma chemoresistance	11
Electroacupuncture may alleviate inflammatory pain by downregulating the expression of P2Y14 receptor in the primary somatosensory cortex	10
Diadenosine pentaphosphate regulates dendrite growth and number in cultured hippocampal neurons	10

Correction to: A1R–A2AR heteromers coupled to Gs and Gi/0 proteins modulate GABA transport into astrocytes	10
The effect of P2RX7 functional SNPs on osteoblast cell phenotype, function and signalling- roles in bone homeostasis and osteogenesis	10
P2Y14 receptor activation and neutrophil signaling: linking inflammation to systemic pathophysiology	9
Macrophage P2Y6 receptor signalling as a key mediator and therapeutic target in atherosclerosis	9
Increased P2X7 level does not affect anxiety or stress-coping behavior in male mice	9
The P2Y2 receptor as a sensor of nucleotides and cell recruitment during inflammatory processes of the liver	9
Identification of the promoter region of the human P2RX7 gene	9
Editorial: purinergic signalling—perspectives from Australia and New Zealand	9
Functional role of peripheral P2X3 receptor expression in trigeminal ganglion neurons: a microarray-based evaluation of the antagonist effect of P2X3	9
Purinergic system in cancer stem cells	8
Pharmacological characterization of P2Y receptor subtypes – an update	8
Preface to special issue “A tribute to Maria Teresa Miras-Portugal”	8
P2Y11/IL-1 receptor crosstalk controls macrophage inflammation: a novel target for anti-inflammatory strategies?	8
The P2X4-P2X7 purinergic axis in alcohol-related liver disease: from fibrogenesis to immunotherapy resistance	8
Extracellular ATP induces the proinflammatory phenotype transition of MH7A cells by activating P2X7 receptor	8
Synthesis of new non-natural l-glycosidic flavonoid derivatives and their evaluation as inhibitors of Trypanosoma cruzi ecto-nucleoside triphosphate diphosphohydrolase 1 (TcNTPDase1)	8
Purinergic P2X3 receptors in the carotid body as new therapeutic targets for controlling heart failure	8
Anti-inflammatory and analgesic properties of Polyphyllin VI revealed by network pharmacology and RNA sequencing	7
Ginsenosides enhance P2X7-dependent cytokine secretion from LPS-primed rodent macrophages	7
Benzamide derivatives as allosteric ligands of the human and rat P2X7 receptor	7
Expression of the P2X1 receptor remains in the type II spiral ganglion neurons in the mature rat cochlea	7
P2Y6 promoted pruning of FSTL1 nerves by cutaneous macrophages to reset pain threshold and cardiac function	7
Crosstalk between P2Y receptors and cyclooxygenase activity in inflammation and tissue repair	7
Integrins α3 and α6 promote Th17 cell migration by activating the purinergic receptor P2X4	7
P2Y11 receptor is a critical regulator of extracellular ATP-mediated premature senescence in lung fibroblasts: Implications of ER-Ca+2 release/mitochondrial ROS production signaling pathway	7
Genetic polymorphisms of purinergic P2Y2 receptor were associated with the susceptibility to essential hypertension in Chinese postmenopausal women	7
DUSP1/MKP-1 represents another piece in the P2X7R intracellular signaling puzzle in cerebellar cells: our last journey with Mª Teresa along the purinergic pathways of Eden	7
The anti-inflammatory effect of physical exercise on type 2 diabetes: the role of purinergic signaling	7
Cutaneous melanoma and purinergic modulation by phenolic compounds	7
P2Y6 receptor in the superior cervical ganglion: a key mediator of post-myocardial ischemic sympathetic hyperexcitability via NF-κB mediated neuroinflammation	7
Potential role of the P2X7 receptor in the proliferation of human diffused large B-cell lymphoma	6
ATP and major affective disorders: the involvement of P2X receptors in pathophysiology	6
P2 purinergic receptor expression and function in tumor-related immune cells	6
Mixed circuit training as a non-pharmacological strategy to improve platelet function and oxidative balance in type 2 diabetes: role of purinergic signaling	6
Heterologous expression and biochemical characterization of the recombinant nucleoside triphosphate diphosphohydrolase 2 (LbNTPDase2) from Leishmania (Viannia) braziliensis	6
Partners in health and disease: pineal gland and purinergic signalling	6
Role and recent progress of P2Y12 receptor in cancer development	6
T cell-derived adenosine regulates fibroblast IL-6 formation via A2B receptors in the infarcted heart	6
Editorial—Translation of purinergic drugs into therapeutic use	6
Identification of novel proteins involved in P2X7-mediated signaling cascades	6
Correction to: The role of purinergic P2X3 receptors and endometriosis-associated hyperalgesia	6
Antagonism of the ATP-gated P2X7 receptor inhibits the proliferation of hepatocellular carcinoma cells	6
Phenolic compounds and chemotherapeutic agents differentially regulate P2X receptor subtypes in malignant melanoma	5
The P2X7 receptor: insights from the murine monoclonal antibody clone L4	5
Retraction Note: Modulation of the TGF-β1-induced epithelial to mesenchymal transition (EMT) mediated by P1 and P2 purine receptors in MDCK cells	5
CD39 in the development and progression of pulmonary arterial hypertension	5
Announcement of changes to the Editorial Board	5
Purinergic signaling in liver disease: calcium signaling and induction of inflammation	5
Purinergic P2Y1 and P2Y12 receptors control enteric nervous system activity through neuro-glia-macrophage crosstalk	5
In vivo phenotypic validation of adenosine receptor-dependent activity of non-adenosine drugs	5

Mechanosensitive release of ATP in the urinary bladder mucosa	5
Host-directed therapeutic strategies against apicomplexan parasites: targeting purinergic P2 receptors	5
Light flickering with 40 Hz causes analgesia via activation of a retina-amygdala pathway and the local release of adenosine	5
Correction to: Purinoceptor: a novel target for hypertension	5
Molecular mechanisms of extracellular-ATP-mediated colorectal cancer progression: Implication of purinergic receptors-mediated nucleocytoplasmic shuttling of HuR	5
EU COST Action CA21130 PRESTO ‘P2X receptors as therapeutic targets’ inaugural meeting report	5
Abnormal purinergic signaling contributes to development of renal cysts in autosomal dominant polycystic kidney disease	4
The enzymatic degradation of ATP to adenosine by microglial CD39 regulates neurovascular coupling and metabolic supply to the brain	4
Combined oral contraceptives alter ectonucleotidase and adenosine deaminase activities in peripheral blood cells	4
Correction to: The analgesic effect of electroacupuncture in alleviating paclitaxel-induced peripheral neuropathic pain and its possible mechanism relates to TLR4/P2X7-NLRP3 signaling pathway	4
ATP released from dying cancer cells stimulates P2X4 receptors and mTOR in their neighbors	4
Screening herbal and natural product libraries to aid discovery of novel allosteric modulators of human P2X7	4
Transactivation of receptor tyrosine kinases by purinergic P2Y and adenosine receptors	4
The P2X7 receptor in leukemia: pathological mechanisms and therapeutic potential	4
Turning failure into success: how artificial intelligence can help personalize therapies and re-use patient data	4
Latest advances on the role of P2X Receptors in colorectal inflammation and cancer	4
Third meeting of the Australian and New Zealand Purine Club	4
Unexpected role of microglia and P2Y12 in the induction of and emergence from anesthesia	4
The P2Y2 receptor: a new player in taste buds	4
CD39 activities in the treated acupoints contributed to the analgesic mechanism of acupuncture on arthritis rats	4
Therapeutic potential of P2X7 receptor in retinal diseases	4
Gene expression alterations of purinergic signaling components in obesity-associated intestinal low-grade inflammation in type 2 diabetes	4
The antidepressant-like effect of guanosine involves the modulation of adenosine A1 and A2A receptors	4
Caffeine plus haloperidol reduces fatigue in an experimental model of Parkinson's disease – a prospective to A2AR-D2R heterodimer antagonism	4
Adenosine A2A receptor signaling in neuroinflammation, glial modulation, and mechanisms associated with chronic pain	4
A step-by-step protocol based on data mining to explore purinergic signaling in glioblastoma	3
P2Y14 receptors: a new target for treating ulcerative colitis	3
Schwann cells transplantation improves nerve injury and alleviates neuropathic pain in rats	3
Caffeine reduces viability, induces apoptosis, inhibits migration and modulates the CD39/CD73 axis in metastatic cutaneous melanoma cells	3
The purinergic signaling interfaces in breast cancer angiogenesis	3
P2X7 receptor is essential for ST36-attenuated cardiac fibrosis upon beta-adrenergic insult	3
Caffeine: a potential mechanism for anti-obesity	3
P2 X 7 receptor is a critical regulator of extracellular ATP-induced profibrotic genes expression in rat kidney: implication of transforming growth factor-β/Smad signaling pathway	3
P2X7 receptor in macrophage polarization and its implications in neuroblastoma tumor behavior	3
The role of purinergic P2X3 receptors and endometriosis-associated hyperalgesia	3
Acute effects of a single electroacupuncture session on purinergic signaling and inflammatory markers in patients with chronic nonspecific low back pain: a pilot study	3
The role of purinergic signaling in acupuncture-mediated relief of neuropathic and inflammatory pain	3
Hematopoietic stem cells on the crossroad between purinergic signaling and innate immunity	3
The role and therapeutic potential of purinergic signaling pathway in metabolic syndrome-related atherosclerosis	3
Functional role of P2X7 purinergic receptor in cancer and cancer-related pain	3
Adenosine receptors and acute kidney injury: perspectives for future therapy	3
Differently expression of the metabotropic P2Y receptor family after hypoxia-induced seizures in neonates and seizure suppression via P2Y1 receptor agonism	3
Transcriptomic analysis reveals novel age-independent immunomodulatory proteins as a mode of cerebroprotection in P2X4 receptor knockout mice after ischemic stroke	3
The impact of purine nucleosides on neuroplasticity in the adult brain	3
Rosmarinic acid modulates purinergic signaling and induces apoptosis in melanoma cells	3
Activation of P2X4 receptors in midbrain cerebrospinal fluid-contacting nucleus leads to mechanical hyperalgesia in chronic constriction injury rats	3
Involvement of purinergic signalling in the vasomotor response to hypochlorous acid in porcine coronary artery	3
ADP as a novel stimulus for NLRP3-inflammasome activation in mice fails to translate to humans	3
P2X7 and P2Y1 receptors in DRG mediate electroacupuncture to inhibit peripheral sensitization in rats with IBS visceral pain	3
P2Y12 receptor-mediated cyclooxygenase 2 (COX-2) expression enhances tumor cell progression in a mouse model of lymphoma	3
A tale of two ATPs: biased activation of the P2X3 receptor	2
Functional expression of the ATP-gated P2X7 receptor in human iPSC-derived astrocytes	2
Tumor growth inhibitory activity of the P2X7 receptor antagonist AZ10606120 in two cell lines of human glioblastoma	2
ATP breakdown in plasma of children limits the antimicrobial effectiveness of their neutrophils	2
Cell cycle regulation by ADP and IGF-1 in cultured late developing glia progenitors of the avian retina	2
Covalently Binding Adenosine A3 Receptor Agonist ICBM Irreversibly Reduces Voltage-Gated Ca2+ Currents in Dorsal Root Ganglion Neurons	2
The analgesic effect of electroacupuncture in alleviating paclitaxel-induced peripheral neuropathic pain and its possible mechanism relates to TLR4/P2X7-NLRP3 signaling pathway	2
Istradefylline modulates purinergic enzymes and reduces malignancy-associated factors in B16F10 melanoma cells	2
CD73 polymorphisms are associated with schizophrenia	2
Modulation of osteoblast differentiation and function by the P2X4 receptor	2
Editorial: Small molecules and biologics for future purinergic therapeutics	2
First evidence of Tityus confluens Borelli, 1899 (Buthidae) venom altering purine metabolism in rat blood cells	2
Responsiveness to adenosine diphosphate on carotid arterial and platelet functions in type 2 diabetic Otsuka Long-Evans Tokushima Fatty rats	2
Correction to: Regulation of TrkB receptor translocation to lipid rafts by adenosine A2A receptors and its functional implications for BDNF-induced regulation of synaptic plasticity	2
Metastasis and angiogenesis in cervical cancer: key aspects of purinergic signaling in platelets and possible therapeutic targets	2
Publisher Correction to: Adenosine receptor signalling in Alzheimer’s disease	2
Preclinical and clinical aspects of P2X receptors as a common route in different diseases: A meeting report	2
Retraction Note: Lysophosphatidylcholine induces adenosine release from macrophages via TRPM7-mediated mitochondrial activation	2
Inhibition of P2X7 receptors by Lu AF27139 diminishes colonic hypersensitivity and CNS prostanoid levels in a rat model of visceral pain	2
Electroacupuncture regulates the P2X7R-NLRP3 inflammatory cascade to relieve decreased sensation on ocular surface of type 2 diabetic rats with dry eye	2
P2 purinergic receptors regulate the progression of colorectal cancer	2
Capsaicin suppresses LPS-induced inflammatory responses via NLRP3/CASP-1/IL-1β axis and purinergic pathways in BV-2 microglial cells	2
Astrocytic P2X7 receptor regulates depressive-like behavioral reactions of mice in response to acute stressful stimulation	2
SCH58261 effectively prevents the reduction in excitability of striatal MSNs in mice following 20 h of sleep deprivation	2
Acute effects of guanosine or inosine in a porcine model of hemorrhagic shock	2
Inflammation, oxidative stress and purinergic signaling in pituitary neuroendocrine tumors (PitNETs)	2
Blockage of the adenosine A2B receptor prevents cardiac fibroblasts overgrowth in rats with pulmonary arterial hypertension	2
A2A receptors: a new target for immunotherapy resistance in prostate cancer	2
Breast cancer patients present pro-tumor biomarkers related to purinergic signaling and oxidative stress	2