OOIR: Observatory of International Research

Papers

(The median citation count of Purinergic Signalling is 2. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-09-01 to 2025-09-01.)

Article	Citations
Some reflections after a long life in science	45
Hippocampal astrocytes relieve anxiogenic behavior by increasing, via the release of ATP, excitatory synaptic transmission in dentate gyrus granule cells	37
P2Y12 receptor antagonism inhibits proliferation, migration and leads to autophagy of glioblastoma cells	32
Characterization of purinergic signaling in tumor-infiltrating lymphocytes from lower- and high-grade gliomas	30
Neuroprotection of exercise: P2X4R and P2X7R regulate BDNF actions	29
Electroacupuncture may alleviate diabetic neuropathic pain by inhibiting the microglia P2X4R and neuroinflammation	23
The impact of inosine on hippocampal synaptic transmission and plasticity involves the release of adenosine through equilibrative nucleoside transporters rather than the direct activation of adenosine	22
Purinergic P2X7 receptor involves in anti-retinal photodamage effects of berberine	21
Role of the P2X7 receptor in breast cancer progression	20
P2X7 receptor promotes migration and invasion of non-small cell lung cancer A549 cells through the PI3K/Akt pathways	19
Promoting glymphatic flow: A non-invasive strategy using 40 Hz light flickering	19
Human plasmacytoid dendritic cells express the functional purinergic halo (CD39/CD73)	19
The exploration of active components of 701 Dieda Zhentong patch and analgesic properties on chronic constriction injury rats	18
Moxibustion pre-treatment attenuates seizure severity during status epilepticus and counteracts the proconvulsant function of the purinergic P2X7 receptor	18
Correction to: A1R–A2AR heteromers coupled to Gs and Gi/0 proteins modulate GABA transport into astrocytes	17
Diadenosine pentaphosphate regulates dendrite growth and number in cultured hippocampal neurons	15
Effects of nanoflubendazole and purinergic signaling modulation in overcoming neuroblastoma chemoresistance	15
Astrocytic adenosine A2B receptors: a crucial player in brain function	14
ENTPD1 (CD39) and NT5E (CD73) expression in human medulloblastoma: an in silico analysis	14
Purinergic receptors mediate endothelial dysfunction and participate in atherosclerosis	14
Macrophage P2Y6 receptor signalling as a key mediator and therapeutic target in atherosclerosis	14
The P2Y2 receptor as a sensor of nucleotides and cell recruitment during inflammatory processes of the liver	13
Inhibiting the P2Y13 receptor reduces IL-33 and HMGB1 lung concentrations and inflammatory cell infiltration in a murine model of asthma	13
Pharmacological interaction and immune response of purinergic receptors in therapeutic modulation	13
Purines help determine the gut’s sweet tooth	13

Editorial: purinergic signalling—perspectives from Australia and New Zealand	13
Purinergic P2X3 receptors in the carotid body as new therapeutic targets for controlling heart failure	13
Electroacupuncture may alleviate inflammatory pain by downregulating the expression of P2Y14 receptor in the primary somatosensory cortex	13
Second meeting of the Australian and New Zealand Purine Club	12
MicroRNA: Crucial modulator in purinergic signalling involved diseases	12
Mono-ADP-ribosylation sites of human CD73 inhibit its adenosine-generating enzymatic activity	12
Pharmacological characterization of P2Y receptor subtypes – an update	12
Preface to special issue “A tribute to Maria Teresa Miras-Portugal”	11
P2 purinergic receptor dysregulation in urologic disease	11
Synthesis of new non-natural l-glycosidic flavonoid derivatives and their evaluation as inhibitors of Trypanosoma cruzi ecto-nucleoside triphosphate diphosphohydrolase 1 (TcNTPDase1)	11
Pharmacological characterization of DPTN and other selective A3 adenosine receptor antagonists	11
NPP1 and TNAP hydrolyze ATP synergistically during biomineralization	11
Pleiotropic effects of clopidogrel	11
RETRACTED ARTICLE: Lysophosphatidylcholine induces adenosine release from macrophages via TRPM7-mediated mitochondrial activation	10
May be adenosine an immuno-quorum-sensing signal?	10
Genetic polymorphisms of purinergic P2Y2 receptor were associated with the susceptibility to essential hypertension in Chinese postmenopausal women	10
Purinergic system in cancer stem cells	10
Crosstalk between P2Y receptors and cyclooxygenase activity in inflammation and tissue repair	9
Cutaneous melanoma and purinergic modulation by phenolic compounds	9
DUSP1/MKP-1 represents another piece in the P2X7R intracellular signaling puzzle in cerebellar cells: our last journey with Mª Teresa along the purinergic pathways of Eden	9
P2Y11/IL-1 receptor crosstalk controls macrophage inflammation: a novel target for anti-inflammatory strategies?	9
The role of Pannexin-1 channels and extracellular ATP in the pathogenesis of the human immunodeficiency virus	9
Ginsenosides enhance P2X7-dependent cytokine secretion from LPS-primed rodent macrophages	8
Identification of novel proteins involved in P2X7-mediated signaling cascades	8
P2Y6 promoted pruning of FSTL1 nerves by cutaneous macrophages to reset pain threshold and cardiac function	8
The anti-inflammatory effect of physical exercise on type 2 diabetes: the role of purinergic signaling	8
Adenosine receptor signalling in Alzheimer’s disease	8
Partners in health and disease: pineal gland and purinergic signalling	8
Anti-inflammatory and analgesic properties of Polyphyllin VI revealed by network pharmacology and RNA sequencing	8
Mechanisms of ATP release in pain: role of pannexin and connexin channels	8
Correction to: The role of purinergic P2X3 receptors and endometriosis-associated hyperalgesia	8
Editorial—Translation of purinergic drugs into therapeutic use	7
Heterologous expression and biochemical characterization of the recombinant nucleoside triphosphate diphosphohydrolase 2 (LbNTPDase2) from Leishmania (Viannia) braziliensis	7
Potential role of the P2X7 receptor in the proliferation of human diffused large B-cell lymphoma	7
Fluorescent A2A and A3 adenosine receptor antagonists as flow cytometry probes	7
P2Y11 receptor is a critical regulator of extracellular ATP-mediated premature senescence in lung fibroblasts: Implications of ER-Ca+2 release/mitochondrial ROS production signaling pathway	7
Analgesic effect of electroacupuncture on bone cancer pain in rat model: the role of peripheral P2X3 receptor	7
Quinacrine is not a vital fluorescent probe for vesicular ATP storage	6
In vivo phenotypic validation of adenosine receptor-dependent activity of non-adenosine drugs	6
Role and recent progress of P2Y12 receptor in cancer development	6
Antagonism of the ATP-gated P2X7 receptor inhibits the proliferation of hepatocellular carcinoma cells	6
Purinergic P2Y1 and P2Y12 receptors control enteric nervous system activity through neuro-glia-macrophage crosstalk	6
Retraction Note: Modulation of the TGF-β1-induced epithelial to mesenchymal transition (EMT) mediated by P1 and P2 purine receptors in MDCK cells	6
T cell-derived adenosine regulates fibroblast IL-6 formation via A2B receptors in the infarcted heart	6
P2 purinergic receptor expression and function in tumor-related immune cells	6
CD39 in the development and progression of pulmonary arterial hypertension	6
Mechanosensitive release of ATP in the urinary bladder mucosa	5
Gallic acid modulates purine metabolism and oxidative stress induced by ethanol exposure in zebrafish brain	5
Purinergic signaling as a new mechanism underlying physical exercise benefits: a narrative review	5
The enzymatic degradation of ATP to adenosine by microglial CD39 regulates neurovascular coupling and metabolic supply to the brain	5

Correction to: Purinoceptor: a novel target for hypertension	5
Ectonucleotidases as bridge between the ATP and adenosine world: reflections on Geoffrey Burnstock	5
EU COST Action CA21130 PRESTO ‘P2X receptors as therapeutic targets’ inaugural meeting report	5
Purinergic modulation of the immune response to infections	5
Burnstock oration — purinergic signalling in kidney transplantation	5
Purinergic signaling in liver disease: calcium signaling and induction of inflammation	5
Molecular mechanisms of extracellular-ATP-mediated colorectal cancer progression: Implication of purinergic receptors-mediated nucleocytoplasmic shuttling of HuR	5
Transactivation of receptor tyrosine kinases by purinergic P2Y and adenosine receptors	5
The P2Y2 receptor: a new player in taste buds	5
Announcement of changes to the Editorial Board	5
Combined oral contraceptives alter ectonucleotidase and adenosine deaminase activities in peripheral blood cells	4
Screening herbal and natural product libraries to aid discovery of novel allosteric modulators of human P2X7	4
Gene expression alterations of purinergic signaling components in obesity-associated intestinal low-grade inflammation in type 2 diabetes	4
Purinoceptor: a novel target for hypertension	4
The antidepressant-like effect of guanosine involves the modulation of adenosine A1 and A2A receptors	4
A major role for adenosine A2A receptor in the interaction between astrocytes and myelinated neurons: possible implications for the therapy of neurodegenerative disorders	4
CD39 activities in the treated acupoints contributed to the analgesic mechanism of acupuncture on arthritis rats	4
NT5E gene and CD38 protein as potential prognostic biomarkers for childhood B-acute lymphoblastic leukemia	4
Adenosine signaling mediate pain transmission in the central nervous system	4
Unexpected role of microglia and P2Y12 in the induction of and emergence from anesthesia	4
ATP released from dying cancer cells stimulates P2X4 receptors and mTOR in their neighbors	4
Therapeutic potential of P2X7 receptor in retinal diseases	4
Spinal cord astrocyte P2X7Rs mediate the inhibitory effect of electroacupuncture on visceral hypersensitivity of rat with irritable bowel syndrome	4
P2X receptors in the balance between inflammation and pathogen control in sepsis	4
The P2X7 receptor in leukemia: pathological mechanisms and therapeutic potential	4
Third meeting of the Australian and New Zealand Purine Club	4
A step-by-step protocol based on data mining to explore purinergic signaling in glioblastoma	3
Rosmarinic acid modulates purinergic signaling and induces apoptosis in melanoma cells	3
P2X7 receptor involved in antitumor activity of atractylenolide I in human cervical cancer cells	3
Involvement of purinergic signalling in the vasomotor response to hypochlorous acid in porcine coronary artery	3
P2X7 receptor in macrophage polarization and its implications in neuroblastoma tumor behavior	3
The impact of purine nucleosides on neuroplasticity in the adult brain	3
P2Y14 receptors: a new target for treating ulcerative colitis	3
Schwann cells transplantation improves nerve injury and alleviates neuropathic pain in rats	3
Role of the extracellular ATP/pyrophosphate metabolism cycle in vascular calcification	3
Long non-coding RNA MSTRG.81401 short hairpin RNA relieves diabetic neuropathic pain and behaviors of depression by inhibiting P2X4 receptor expression in type 2 diabetic rats	3
Adenosine receptors and acute kidney injury: perspectives for future therapy	3
Is the regulation by miRNAs of NTPDase1 and ecto-5’-nucleotidase genes involved with the different profiles of breast cancer subtypes?	3
Activation of P2X4 receptors in midbrain cerebrospinal fluid-contacting nucleus leads to mechanical hyperalgesia in chronic constriction injury rats	3
The P2X1 receptor as a therapeutic target	3
Transcriptomic analysis reveals novel age-independent immunomodulatory proteins as a mode of cerebroprotection in P2X4 receptor knockout mice after ischemic stroke	3
Differently expression of the metabotropic P2Y receptor family after hypoxia-induced seizures in neonates and seizure suppression via P2Y1 receptor agonism	3
The role of purinergic signaling in acupuncture-mediated relief of neuropathic and inflammatory pain	3
Adenosine A2A receptor controls the gateway of the choroid plexus	3
Hematopoietic stem cells on the crossroad between purinergic signaling and innate immunity	3
The role of purinergic P2X3 receptors and endometriosis-associated hyperalgesia	3
Caffeine reduces viability, induces apoptosis, inhibits migration and modulates the CD39/CD73 axis in metastatic cutaneous melanoma cells	3
Caffeine plus haloperidol reduces fatigue in an experimental model of Parkinson's disease – a prospective to A2AR-D2R heterodimer antagonism	3
ADP as a novel stimulus for NLRP3-inflammasome activation in mice fails to translate to humans	2
P2 purinergic receptors regulate the progression of colorectal cancer	2
The real-time detection of acupuncture-induced extracellular ATP mobilization in acupoints and exploration of its role in acupuncture analgesia	2
Novel possibility for cutaneous melanoma treatment by means of rosmarinic acid action on purinergic signaling	2
Preclinical and clinical aspects of P2X receptors as a common route in different diseases: A meeting report	2
Editorial: Small molecules and biologics for future purinergic therapeutics	2
First evidence of Tityus confluens Borelli, 1899 (Buthidae) venom altering purine metabolism in rat blood cells	2
Acute effects of guanosine or inosine in a porcine model of hemorrhagic shock	2
Astrocytic P2X7 receptor regulates depressive-like behavioral reactions of mice in response to acute stressful stimulation	2
The P2X7 receptor is a target of p53 and regulates haematopoiesis following radiation-induced genotoxic stress	2
P2X7 and P2Y1 receptors in DRG mediate electroacupuncture to inhibit peripheral sensitization in rats with IBS visceral pain	2
P2X7 receptor is essential for ST36-attenuated cardiac fibrosis upon beta-adrenergic insult	2
Functional role of P2X7 purinergic receptor in cancer and cancer-related pain	2
Publisher Correction to: Adenosine receptor signalling in Alzheimer’s disease	2
Retraction Note: Lysophosphatidylcholine induces adenosine release from macrophages via TRPM7-mediated mitochondrial activation	2
Electroacupuncture regulates the P2X7R-NLRP3 inflammatory cascade to relieve decreased sensation on ocular surface of type 2 diabetic rats with dry eye	2
ATP, an attractive target for the treatment of refractory chronic cough	2
P2Y12 receptor gene polymorphisms are associated with epilepsy	2
Correction to: Regulation of TrkB receptor translocation to lipid rafts by adenosine A2A receptors and its functional implications for BDNF-induced regulation of synaptic plasticity	2
SCH58261 effectively prevents the reduction in excitability of striatal MSNs in mice following 20 h of sleep deprivation	2
Covalently Binding Adenosine A3 Receptor Agonist ICBM Irreversibly Reduces Voltage-Gated Ca2+ Currents in Dorsal Root Ganglion Neurons	2
Caffeine: a potential mechanism for anti-obesity	2
P2 X 7 receptor is a critical regulator of extracellular ATP-induced profibrotic genes expression in rat kidney: implication of transforming growth factor-β/Smad signaling pathway	2
Metastasis and angiogenesis in cervical cancer: key aspects of purinergic signaling in platelets and possible therapeutic targets	2
P2X7 receptor activation mediates superoxide dismutase 1 (SOD1) release from murine NSC-34 motor neurons	2
Inhibition of P2X7 receptors by Lu AF27139 diminishes colonic hypersensitivity and CNS prostanoid levels in a rat model of visceral pain	2
P2X7 receptor: the regulator of glioma tumor development and survival	2
Functional expression of the ATP-gated P2X7 receptor in human iPSC-derived astrocytes	2
Modulation of osteoblast differentiation and function by the P2X4 receptor	2
ATP breakdown in plasma of children limits the antimicrobial effectiveness of their neutrophils	2
Cell cycle regulation by ADP and IGF-1 in cultured late developing glia progenitors of the avian retina	2
P2Y12 receptor-mediated cyclooxygenase 2 (COX-2) expression enhances tumor cell progression in a mouse model of lymphoma	2