OOIR: Observatory of International Research

Papers

(The TQCC of Purinergic Signalling is 5. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-06-01 to 2025-06-01.)

Article	Citations
Neuroprotection of exercise: P2X4R and P2X7R regulate BDNF actions	42
Some reflections after a long life in science	36
Hippocampal astrocytes relieve anxiogenic behavior by increasing, via the release of ATP, excitatory synaptic transmission in dentate gyrus granule cells	36
The impact of inosine on hippocampal synaptic transmission and plasticity involves the release of adenosine through equilibrative nucleoside transporters rather than the direct activation of adenosine	30
Role of the P2X7 receptor in breast cancer progression	29
Characterization of purinergic signaling in tumor-infiltrating lymphocytes from lower- and high-grade gliomas	28
Substrate binding modes of purine and pyrimidine nucleotides to human ecto-5′-nucleotidase (CD73) and inhibition by their bisphosphonic acid derivatives	25
P2Y12 receptor antagonism inhibits proliferation, migration and leads to autophagy of glioblastoma cells	23
Purinergic P2X7 receptor involves in anti-retinal photodamage effects of berberine	21
Electroacupuncture may alleviate diabetic neuropathic pain by inhibiting the microglia P2X4R and neuroinflammation	19
UTP is a regulator of in vitro and in vivo angiogenic properties of cardiac adipose–derived stem cells	19
Moxibustion pre-treatment attenuates seizure severity during status epilepticus and counteracts the proconvulsant function of the purinergic P2X7 receptor	19
The exploration of active components of 701 Dieda Zhentong patch and analgesic properties on chronic constriction injury rats	18
Promoting glymphatic flow: A non-invasive strategy using 40 Hz light flickering	18
Human plasmacytoid dendritic cells express the functional purinergic halo (CD39/CD73)	17
P2X7 receptor promotes migration and invasion of non-small cell lung cancer A549 cells through the PI3K/Akt pathways	16
Purinergic receptors mediate endothelial dysfunction and participate in atherosclerosis	16
Correction to: A1R–A2AR heteromers coupled to Gs and Gi/0 proteins modulate GABA transport into astrocytes	16
Diadenosine pentaphosphate regulates dendrite growth and number in cultured hippocampal neurons	15
Pharmacological interaction and immune response of purinergic receptors in therapeutic modulation	14
Effects of nanoflubendazole and purinergic signaling modulation in overcoming neuroblastoma chemoresistance	14
ENTPD1 (CD39) and NT5E (CD73) expression in human medulloblastoma: an in silico analysis	13
Electroacupuncture may alleviate inflammatory pain by downregulating the expression of P2Y14 receptor in the primary somatosensory cortex	13
Astrocytic adenosine A2B receptors: a crucial player in brain function	13
Macrophage P2Y6 receptor signalling as a key mediator and therapeutic target in atherosclerosis	13

Inhibiting the P2Y13 receptor reduces IL-33 and HMGB1 lung concentrations and inflammatory cell infiltration in a murine model of asthma	12
Purines help determine the gut’s sweet tooth	12
Editorial: purinergic signalling—perspectives from Australia and New Zealand	12
Purinergic P2X3 receptors in the carotid body as new therapeutic targets for controlling heart failure	12
ENTPD5: identification of splicing variants and their impact on cancer survival	12
Second meeting of the Australian and New Zealand Purine Club	11
MicroRNA: Crucial modulator in purinergic signalling involved diseases	11
The P2Y2 receptor as a sensor of nucleotides and cell recruitment during inflammatory processes of the liver	11
Pharmacological characterization of P2Y receptor subtypes – an update	11
Pleiotropic effects of clopidogrel	11
Mono-ADP-ribosylation sites of human CD73 inhibit its adenosine-generating enzymatic activity	11
May be adenosine an immuno-quorum-sensing signal?	10
P2 purinergic receptor dysregulation in urologic disease	10
Pharmacological characterization of DPTN and other selective A3 adenosine receptor antagonists	10
Purinergic system in cancer stem cells	10
Preface to special issue “A tribute to Maria Teresa Miras-Portugal”	10
NPP1 and TNAP hydrolyze ATP synergistically during biomineralization	10
Purinergic ATP triggers moxibustion-induced local anti-nociceptive effect on inflammatory pain model	10
RETRACTED ARTICLE: Lysophosphatidylcholine induces adenosine release from macrophages via TRPM7-mediated mitochondrial activation	9
Genetic polymorphisms of purinergic P2Y2 receptor were associated with the susceptibility to essential hypertension in Chinese postmenopausal women	9
The role of Pannexin-1 channels and extracellular ATP in the pathogenesis of the human immunodeficiency virus	9
Synthesis of new non-natural l-glycosidic flavonoid derivatives and their evaluation as inhibitors of Trypanosoma cruzi ecto-nucleoside triphosphate diphosphohydrolase 1 (TcNTPDase1)	9
P2Y6 promoted pruning of FSTL1 nerves by cutaneous macrophages to reset pain threshold and cardiac function	8
DUSP1/MKP-1 represents another piece in the P2X7R intracellular signaling puzzle in cerebellar cells: our last journey with Mª Teresa along the purinergic pathways of Eden	8
The anti-inflammatory effect of physical exercise on type 2 diabetes: the role of purinergic signaling	8
P2Y11/IL-1 receptor crosstalk controls macrophage inflammation: a novel target for anti-inflammatory strategies?	8
Anti-inflammatory and analgesic properties of Polyphyllin VI revealed by network pharmacology and RNA sequencing	8
Ginsenosides enhance P2X7-dependent cytokine secretion from LPS-primed rodent macrophages	8
Cutaneous melanoma and purinergic modulation by phenolic compounds	8
Crosstalk between P2Y receptors and cyclooxygenase activity in inflammation and tissue repair	8
Partners in health and disease: pineal gland and purinergic signalling	7
Pannexin 3 channels in health and disease	7
Adenosine receptor signalling in Alzheimer’s disease	7
Potential role of the P2X7 receptor in the proliferation of human diffused large B-cell lymphoma	7
Mechanisms of ATP release in pain: role of pannexin and connexin channels	7
Heterologous expression and biochemical characterization of the recombinant nucleoside triphosphate diphosphohydrolase 2 (LbNTPDase2) from Leishmania (Viannia) braziliensis	7
Identification of novel proteins involved in P2X7-mediated signaling cascades	7
Editorial—Translation of purinergic drugs into therapeutic use	6
Purinergic P2Y1 and P2Y12 receptors control enteric nervous system activity through neuro-glia-macrophage crosstalk	6
P2 purinergic receptor expression and function in tumor-related immune cells	6
P2Y11 receptor is a critical regulator of extracellular ATP-mediated premature senescence in lung fibroblasts: Implications of ER-Ca+2 release/mitochondrial ROS production signaling pathway	6
T cell-derived adenosine regulates fibroblast IL-6 formation via A2B receptors in the infarcted heart	6
Antagonism of the ATP-gated P2X7 receptor inhibits the proliferation of hepatocellular carcinoma cells	6
Analgesic effect of electroacupuncture on bone cancer pain in rat model: the role of peripheral P2X3 receptor	6
Fluorescent A2A and A3 adenosine receptor antagonists as flow cytometry probes	6
The ATP/P2X7 axis is a crucial regulator of leukemic initiating cells proliferation and homing and an emerging therapeutic target in acute myeloid leukemia	6
Quinacrine is not a vital fluorescent probe for vesicular ATP storage	6
Pro- and anti-inflammatory macrophages express a sub-type specific purinergic receptor profile	5
Correction to: Purinoceptor: a novel target for hypertension	5
Purinergic signaling in liver disease: calcium signaling and induction of inflammation	5

EU COST Action CA21130 PRESTO ‘P2X receptors as therapeutic targets’ inaugural meeting report	5
Retraction Note: Modulation of the TGF-β1-induced epithelial to mesenchymal transition (EMT) mediated by P1 and P2 purine receptors in MDCK cells	5
Ectonucleotidases as bridge between the ATP and adenosine world: reflections on Geoffrey Burnstock	5
Molecular mechanisms of extracellular-ATP-mediated colorectal cancer progression: Implication of purinergic receptors-mediated nucleocytoplasmic shuttling of HuR	5
Mechanosensitive release of ATP in the urinary bladder mucosa	5
Role and recent progress of P2Y12 receptor in cancer development	5
In vivo phenotypic validation of adenosine receptor-dependent activity of non-adenosine drugs	5
CD39 in the development and progression of pulmonary arterial hypertension	5
Gallic acid modulates purine metabolism and oxidative stress induced by ethanol exposure in zebrafish brain	5