OOIR: Observatory of International Research

Papers

(The TQCC of Purinergic Signalling is 5. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2022-06-01 to 2026-06-01.)

Article	Citations
Some reflections after a long life in science	34
Neuroprotection of exercise: P2X4R and P2X7R regulate BDNF actions	27
Purinergic P2X7 receptor involves in anti-retinal photodamage effects of berberine	27
Hippocampal astrocytes relieve anxiogenic behavior by increasing, via the release of ATP, excitatory synaptic transmission in dentate gyrus granule cells	27
Electroacupuncture may alleviate diabetic neuropathic pain by inhibiting the microglia P2X4R and neuroinflammation	26
Characterization of purinergic signaling in tumor-infiltrating lymphocytes from lower- and high-grade gliomas	25
The impact of inosine on hippocampal synaptic transmission and plasticity involves the release of adenosine through equilibrative nucleoside transporters rather than the direct activation of adenosine	23
Role of the P2X7 receptor in breast cancer progression	21
The potential role of adenosinergic pathway and methylxanthines in Parkinson’s disease: Blowing in the wind or not	20
P2Y12 receptor antagonism inhibits proliferation, migration and leads to autophagy of glioblastoma cells	20
The P2X7 receptor/NLRP3 inflammasome signaling axis in sepsis: molecular mechanisms, organ-specific pathophysiology, and emerging therapeutic strategies	19
The exploration of active components of 701 Dieda Zhentong patch and analgesic properties on chronic constriction injury rats	17
Human plasmacytoid dendritic cells express the functional purinergic halo (CD39/CD73)	17
Promoting glymphatic flow: A non-invasive strategy using 40 Hz light flickering	16
Guanosine contributes to rapid purinergic regulation of dopamine during ischemia	16
Moxibustion pre-treatment attenuates seizure severity during status epilepticus and counteracts the proconvulsant function of the purinergic P2X7 receptor	15
P2X7 receptor promotes migration and invasion of non-small cell lung cancer A549 cells through the PI3K/Akt pathways	15
Astrocytic adenosine A2B receptors: a crucial player in brain function	14
Macrophage P2Y6 receptor signalling as a key mediator and therapeutic target in atherosclerosis	14
Brilliant blue G enhances cardiac function and suppresses ventricular arrhythmias by attenuating inflammation and fibrosis after post-myocardial infarction in rats	14
ENTPD1 (CD39) and NT5E (CD73) expression in human medulloblastoma: an in silico analysis	14
Correction to: A1R–A2AR heteromers coupled to Gs and Gi/0 proteins modulate GABA transport into astrocytes	13
Pharmacological interaction and immune response of purinergic receptors in therapeutic modulation	12
Identification of the promoter region of the human P2RX7 gene	12
Diadenosine pentaphosphate regulates dendrite growth and number in cultured hippocampal neurons	12

Effects of nanoflubendazole and purinergic signaling modulation in overcoming neuroblastoma chemoresistance	12
Increased P2X7 level does not affect anxiety or stress-coping behavior in male mice	12
Electroacupuncture may alleviate inflammatory pain by downregulating the expression of P2Y14 receptor in the primary somatosensory cortex	11
The biphasic regulatory effect of adenosine A2B receptor in ischemic brain injury and its therapeutic potential	10
Functional role of peripheral P2X3 receptor expression in trigeminal ganglion neurons: a microarray-based evaluation of the antagonist effect of P2X3	10
Pharmacological characterization of P2Y receptor subtypes – an update	10
Editorial: purinergic signalling—perspectives from Australia and New Zealand	10
P2Y14 receptor activation and neutrophil signaling: linking inflammation to systemic pathophysiology	10
Purinergic P2X3 receptors in the carotid body as new therapeutic targets for controlling heart failure	10
The P2Y2 receptor as a sensor of nucleotides and cell recruitment during inflammatory processes of the liver	10
Pleiotropic effects of clopidogrel	10
The P2X4-P2X7 purinergic axis in alcohol-related liver disease: from fibrogenesis to immunotherapy resistance	9
Synthesis of new non-natural l-glycosidic flavonoid derivatives and their evaluation as inhibitors of Trypanosoma cruzi ecto-nucleoside triphosphate diphosphohydrolase 1 (TcNTPDase1)	9
Extracellular ATP induces the proinflammatory phenotype transition of MH7A cells by activating P2X7 receptor	9
P2 purinergic receptor dysregulation in urologic disease	9
Preface to special issue “A tribute to Maria Teresa Miras-Portugal”	9
Integrins α3 and α6 promote Th17 cell migration by activating the purinergic receptor P2X4	8
Cutaneous melanoma and purinergic modulation by phenolic compounds	8
RETRACTED ARTICLE: Lysophosphatidylcholine induces adenosine release from macrophages via TRPM7-mediated mitochondrial activation	8
Purinergic system in cancer stem cells	8
Expression of the P2X1 receptor remains in the type II spiral ganglion neurons in the mature rat cochlea	8
P2Y11/IL-1 receptor crosstalk controls macrophage inflammation: a novel target for anti-inflammatory strategies?	8
NPP1 and TNAP hydrolyze ATP synergistically during biomineralization	8
Adenosine receptor signalling in Alzheimer’s disease	7
P2Y6 promoted pruning of FSTL1 nerves by cutaneous macrophages to reset pain threshold and cardiac function	7
P2Y6 receptor in the superior cervical ganglion: a key mediator of post-myocardial ischemic sympathetic hyperexcitability via NF-κB mediated neuroinflammation	7
Ginsenosides enhance P2X7-dependent cytokine secretion from LPS-primed rodent macrophages	7
Anti-inflammatory and analgesic properties of Polyphyllin VI revealed by network pharmacology and RNA sequencing	7
Genetic polymorphisms of purinergic P2Y2 receptor were associated with the susceptibility to essential hypertension in Chinese postmenopausal women	7
Crosstalk between P2Y receptors and cyclooxygenase activity in inflammation and tissue repair	7
Partners in health and disease: pineal gland and purinergic signalling	7
The anti-inflammatory effect of physical exercise on type 2 diabetes: the role of purinergic signaling	7
DUSP1/MKP-1 represents another piece in the P2X7R intracellular signaling puzzle in cerebellar cells: our last journey with Mª Teresa along the purinergic pathways of Eden	7
P2Y11 receptor is a critical regulator of extracellular ATP-mediated premature senescence in lung fibroblasts: Implications of ER-Ca+2 release/mitochondrial ROS production signaling pathway	7
Potential role of the P2X7 receptor in the proliferation of human diffused large B-cell lymphoma	6
Correction to: The role of purinergic P2X3 receptors and endometriosis-associated hyperalgesia	6
Role and recent progress of P2Y12 receptor in cancer development	6
Identification of novel proteins involved in P2X7-mediated signaling cascades	6
Heterologous expression and biochemical characterization of the recombinant nucleoside triphosphate diphosphohydrolase 2 (LbNTPDase2) from Leishmania (Viannia) braziliensis	6
T cell-derived adenosine regulates fibroblast IL-6 formation via A2B receptors in the infarcted heart	6
Fluorescent A2A and A3 adenosine receptor antagonists as flow cytometry probes	6
Editorial—Translation of purinergic drugs into therapeutic use	6
ATP and major affective disorders: the involvement of P2X receptors in pathophysiology	6
Purinergic P2Y1 and P2Y12 receptors control enteric nervous system activity through neuro-glia-macrophage crosstalk	6
Mixed circuit training as a non-pharmacological strategy to improve platelet function and oxidative balance in type 2 diabetes: role of purinergic signaling	5
Correction to: Purinoceptor: a novel target for hypertension	5
Purinergic signaling in liver disease: calcium signaling and induction of inflammation	5
The enzymatic degradation of ATP to adenosine by microglial CD39 regulates neurovascular coupling and metabolic supply to the brain	5
Molecular mechanisms of extracellular-ATP-mediated colorectal cancer progression: Implication of purinergic receptors-mediated nucleocytoplasmic shuttling of HuR	5
Announcement of changes to the Editorial Board	5

Antagonism of the ATP-gated P2X7 receptor inhibits the proliferation of hepatocellular carcinoma cells	5
Retraction Note: Modulation of the TGF-β1-induced epithelial to mesenchymal transition (EMT) mediated by P1 and P2 purine receptors in MDCK cells	5
P2 purinergic receptor expression and function in tumor-related immune cells	5
Phenolic compounds and chemotherapeutic agents differentially regulate P2X receptor subtypes in malignant melanoma	5
EU COST Action CA21130 PRESTO ‘P2X receptors as therapeutic targets’ inaugural meeting report	5
Light flickering with 40 Hz causes analgesia via activation of a retina-amygdala pathway and the local release of adenosine	5
CD39 in the development and progression of pulmonary arterial hypertension	5
In vivo phenotypic validation of adenosine receptor-dependent activity of non-adenosine drugs	5
Gallic acid modulates purine metabolism and oxidative stress induced by ethanol exposure in zebrafish brain	5
Host-directed therapeutic strategies against apicomplexan parasites: targeting purinergic P2 receptors	5
Mechanosensitive release of ATP in the urinary bladder mucosa	5