OOIR: Observatory of International Research

Papers

(The TQCC of Purinergic Signalling is 6. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2020-05-01 to 2024-05-01.)

Article	Citations
High expression levels of pyrimidine metabolic rate–limiting enzymes are adverse prognostic factors in lung adenocarcinoma: a study based on The Cancer Genome Atlas and Gene Expression Omnibus dataset	42
Ectonucleoside triphosphate diphosphohydrolases and ecto-5′-nucleotidase in purinergic signaling: how the field developed and where we are now	41
Purinergic signaling as a basis of acupuncture-induced analgesia	34
Involvement of P2X7 receptors in chronic pain disorders	32
Nociceptive signaling of P2X receptors in chronic pain states	29
Structural basis for the functional properties of the P2X7 receptor for extracellular ATP	28
Antagonism of the ATP-gated P2X7 receptor: a potential therapeutic strategy for cancer	28
Recommended tool compounds and drugs for blocking P2X and P2Y receptors	23
Adult mesenchymal stem cells: is there a role for purine receptors in their osteogenic differentiation?	23
Pannexin 1 as a driver of inflammation and ischemia–reperfusion injury	22
P2X7 receptor antagonism inhibits tumour growth in human high-grade gliomas	22
Purinergic signalling in spinal pain processing	22
P2X7 receptor deletion attenuates oxidative stress and liver damage in sepsis	20
A novel definition and treatment of hyperinflammation in COVID-19 based on purinergic signalling	20
Pannexin-1 channel “fuels” by releasing ATP from bone marrow cells a state of sterile inflammation required for optimal mobilization and homing of hematopoietic stem cells	17
Innate immunity orchestrates the mobilization and homing of hematopoietic stem/progenitor cells by engaging purinergic signaling—an update	17
Nucleotide P2Y1 receptor agonists are in vitro and in vivo prodrugs of A1/A3 adenosine receptor agonists: implications for roles of P2Y1 and A1/A3 receptors in physiology and pathology	16
Targeting the purinergic pathway in breast cancer and its therapeutic applications	16
Purinergic signaling: a potential therapeutic target for depression and chronic pain	16
Pro- and anti-inflammatory macrophages express a sub-type specific purinergic receptor profile	16
Electroacupuncture alleviates diabetic neuropathic pain in rats by suppressing P2X3 receptor expression in dorsal root ganglia	16
Adenosine receptors regulate exosome production	15
Purinergic modulation of the immune response to infections	15
Autocrine and paracrine purinergic signaling in the most lethal types of cancer	15
Design and in vivo activity of A3 adenosine receptor agonist prodrugs	14

Antidepressant-like effect of guanosine involves activation of AMPA receptor and BDNF/TrkB signaling	14
The role of peripheral adenosine receptors in glutamate-induced pain nociceptive behavior	14
Effect of P2X purinergic receptors in tumor progression and as a potential target for anti-tumor therapy	13
Mechanisms of ATP release in pain: role of pannexin and connexin channels	13
Limonene-induced activation of A2A adenosine receptors reduces airway inflammation and reactivity in a mouse model of asthma	13
P2X7 is a cytotoxic receptor….maybe not: implications for cancer	13
To inhibit or to boost the ATP/P2RX7 pathway to fight cancer—that is the question	13
Acupuncture modulates extracellular ATP levels in peripheral sensory nervous system during analgesia of ankle arthritis in rats	12
Comparison of peripheral blood mononuclear cell isolation techniques and the impact of cryopreservation on human lymphocytes expressing CD39 and CD73	12
That was then, this is now: the development of our knowledge and understanding of P2 receptor subtypes	12
Pannexin 3 channels in health and disease	12
Guanosine modulates SUMO2/3-ylation in neurons and astrocytes via adenosine receptors	12
Purinergic receptors mediate endothelial dysfunction and participate in atherosclerosis	11
Cystic fibrosis improves COVID-19 survival and provides clues for treatment of SARS-CoV-2	11
Molecular probes for the human adenosine receptors	11
Caffeine has a dual influence on NMDA receptor–mediated glutamatergic transmission at the hippocampus	10
Regulation of tumor infiltrated innate immune cells by adenosine	10
P2X7 receptor: the regulator of glioma tumor development and survival	10
Exploration of the link between gut microbiota and purinergic signalling	10
Influence of NSAIDs and methotrexate on CD73 expression and glioma cell growth	10
Characterization of the N6-etheno-bridge method to assess extracellular metabolism of adenine nucleotides: detection of a possible role for purine nucleoside phosphorylase in adenosine metabolism	10
Dorsal root ganglia P2X4 and P2X7 receptors contribute to diabetes-induced hyperalgesia and the downregulation of electroacupuncture on P2X4 and P2X7	9
Involvement of adenosine A1 and A2A receptors on guanosine-mediated anti-tremor effects in reserpinized mice	9
P2X3 receptors contribute to transition from acute to chronic muscle pain	9
Optimized HPLC method to elucidate the complex purinergic signaling dynamics that regulate ATP, ADP, AMP, and adenosine levels in human blood	9
Effect of the conditioned medium of mesenchymal stem cells on the expression levels of P2X4 and P2X7 purinergic receptors in the spinal cord of rats with neuropathic pain	9
Electroacupuncture improves myocardial ischemia injury via activation of adenosine receptors	9
Novel possibility for cutaneous melanoma treatment by means of rosmarinic acid action on purinergic signaling	9
Adenosine signaling mediate pain transmission in the central nervous system	8
Purinergic signaling as a new mechanism underlying physical exercise benefits: a narrative review	8
ATP, an attractive target for the treatment of refractory chronic cough	8
Pharmacological characterization of DPTN and other selective A3 adenosine receptor antagonists	8
Protective effects of dihydromyricetin on primary hippocampal astrocytes from cytotoxicity induced by comorbid diabetic neuropathic pain and depression	8
Inhibition of phosphorylated calcium/calmodulin-dependent protein kinase IIα relieves streptozotocin-induced diabetic neuropathic pain through regulation of P2X3 receptor in dorsal root ganglia	8
Real-time measurement of adenosine and ATP release in the central nervous system	8
P2X7 receptor activation mediates superoxide dismutase 1 (SOD1) release from murine NSC-34 motor neurons	8
Enlightening activation gating in P2X receptors	7
P2X7 siRNA targeted to the kidneys increases klotho and delays the progression of experimental diabetic nephropathy	7
Analgesic effect of electroacupuncture on bone cancer pain in rat model: the role of peripheral P2X3 receptor	7
The P2X1 receptor as a therapeutic target	7
Contribution of P2X4 receptor in pain associated with rheumatoid arthritis: a review	7
MicroRNA: Crucial modulator in purinergic signalling involved diseases	7
Neutrophils: fast and furious—the nucleotide pathway	7
Substrate binding modes of purine and pyrimidine nucleotides to human ecto-5′-nucleotidase (CD73) and inhibition by their bisphosphonic acid derivatives	7
A2A adenosine receptor activation prevents neutrophil aging and promotes polarization from N1 towards N2 phenotype	7
NPP1 and TNAP hydrolyze ATP synergistically during biomineralization	7
Professor Dr. Geoffrey Burnstock (1929–2020)	7
P2X7Rs: new therapeutic targets for osteoporosis	7
The P2 purinoceptors in prostate cancer	7
ATP transporters in the joints	7

The real-time detection of acupuncture-induced extracellular ATP mobilization in acupoints and exploration of its role in acupuncture analgesia	6
The P2X7 ion channel is dispensable for energy and metabolic homeostasis of white and brown adipose tissues	6
Extracellular creatine kinase may modulate purinergic signalling	6
Involvement of ectonucleotidases and purinergic receptor expression during acute Chagas disease in the cortex of mice treated with resveratrol and benznidazole	6
Deletion of the adenosine A2A receptor increases the survival rate in a mice model of polymicrobial sepsis	6
P2Y1R and P2Y2R: potential molecular triggers in muscle regeneration	6
Geoffery Burnstock’s influence on the evolution of P2X3 receptor pharmacology	6
Impaired UTP-induced relaxation in the carotid arteries of spontaneously hypertensive rats	6
The history of the Purine Club: a tribute to Prof. Geoffrey Burnstock	6
The antidepressant-like effect of guanosine involves the modulation of adenosine A1 and A2A receptors	6
Involvement of purinergic P2Y1R in antidepressant-like effects of electroacupuncture treatment on social isolation stress mice	6
Tribute to Prof. Geoffrey Burnstock: his contribution to acupuncture	6
Effects of intranasal guanosine administration on brain function in a rat model of ischemic stroke	6
Purinergic signalling in the cardiovascular system—a tribute to Geoffrey Burnstock	6
Species dependence of A3 adenosine receptor pharmacology and function	6
Adenosine receptor signalling in Alzheimer’s disease	6
P2X7 receptor involved in antitumor activity of atractylenolide I in human cervical cancer cells	6
Spinal P2X4 Receptors Involved in Visceral Hypersensitivity of Neonatal Maternal Separation Rats	6
COVID-19 and purinergic signaling: the need for investigation	6