Cancer Biomarkers

Article	Citations
RAB27B expression in pancreatic cancer is predictive of poor survival but good response to chemotherapy	78
miR-383-5p serves as a tumor suppressor in bladder cancer by suppressing PI3K/AKT signaling pathway	72
KIAA1429-mediated RXFP1 attenuates non-small cell lung cancer tumorigenesis via N6-methyladenosine modification	59
Risk stratification of pancreatic cancer by a blood test for apolipoprotein A2-isoforms	39
The clinical significance and function of EGFR mutation in TKI treatments of NSCLC patients	37
Preoperative albumin-alkaline phosphatase ratio affects the prognosis of patients undergoing hepatocellular carcinoma surgery	28
Involvement of FAM170B-AS1, hsa-miR-1202, and hsa-miR-146a-5p in breast cancer	28
The effect of low-intensity resistance exercise training on Serum tumor biomarkers and quality of life in women with breast cancer: A randomized controlled trial	23
Individual recombinant repeats of MUC16 display variable binding to CA125 antibodies	23
Machine learning identifies a 5-serum cytokine panel for the early detection of chronic atrophy gastritis patients	21
Identification of TNFRSF1A as a potential biomarker for osteosarcoma	20
High TCTA expression is an adverse prognostic biomarker in acute myeloid leukemia	17
Impact of the peripheral blood inflammatory indices and modified nomogram-revised risk index on survival of Extranodal Nasal-Type Natural Killer/T-Cell lymphoma	17
Erratum to: Annexin A5 overexpression might suppress proliferation and metastasis of human uterine cervical carcinoma cells	16
TET-2 mutations predict poor outcomes and are associated with unfavorable clinical-biological features in PTCL, not otherwise specified and angioimmunoblastic T-cell lymphoma in Brazilian patients	14
YTHDF1 amplification is correlated with worse outcome and lower immune cell infiltrations in breast cancer	14
Methylation of FBN1, SPG20, ITF2, RUNX3, SNCA, MLH1, and SEPT9 genes in circulating cell-free DNA as biomarkers of colorectal cancer	14
US-Japan collaboration: Collaboration across international boundary	13
Volume doubling time and radiomic features predict tumor behavior of screen-detected lung cancers	13
KLF5 inhibits the migration and invasion in cervical cancer cell lines by regulating SNAI1	13
Identification of a novel necroptosis-related LncRNA signature for prognostic prediction and immune response in oral squamous cell carcinoma	13
GINS2 promotes the progression of human HNSCC by altering RRM2 expression	13
Multi-omics pan-cancer analysis of monocyte to macrophage differentiation-associated (MMD) and its significance in hepatocellular carcinoma	13
Machine learning reveals the role of telomerase activation-related genes in the prognosis of neuroblastoma	13
Integrative analysis of histone acetyltransferase KAT2A in human cancer	13

Expression of serum HMGB1, SAA, and TSGF in patients with colon cancer and the value of prognostic assessment	12
Identification of candidate biomarkers and prognostic analysis of recurrence in colorectal cancer	12
From discovery to clinical implementation of a pancreatic blood biomarker, apolipoprotein A2 isoform	12
Analysis of clinical significance and molecular characteristics of methionine metabolism and macrophage-related patterns in hepatocellular carcinoma based on machine learning	11
A risk model based on signature genes predicts prognosis and associates with tumor immunity, drug sensitivity in breast cancer	11
A pilot study to troubleshoot quality control metrics when assessing circulating miRNA expression data reproducibility across study sites	11
Albumin-bilirubin score predicts trastuzumab resistance in HER2-positive breast cancer	10
Assessing the clinical utility of biomarkers using the intervention probability curve (IPC)	10
EGFR, HLA-G, CD70, c-MET, and NY-ESO1 as potential biomarkers in high grade epithelial ovarian carcinoma	10
Down-regulated MiRNA 29-b as a diagnostic marker in colorectal cancer and its correlation with ETV4 and Cyclin D1 immunohistochemical expression	9
CHRDL1, NEFH, TAGLN and SYNM as novel diagnostic biomarkers of benign prostatic hyperplasia and prostate cancer	9
Investigating whether exosomal miR-205-5p derived from tongue squamous cell carcinoma cells stimulates the angiogenic activity of HUVECs by targeting AMOT	9
Identification of prognostic biomarkers among ICAMs in the breast cancer microenvironment	9
ELAPOR1 suppresses tumor progression in colorectal cancer and indicates favorable prognosis	9
SLAMF8 expression and prognostic significance in melanoma: A multi-omics and Mendelian randomization study	9
CPT1B, a metabolic molecule, is also an independent risk factor in CN-AML	9
TRB CDR3-cancer testis antigen chemical complementarity scoring for identifying productive immune responses in renal cell carcinoma	9
Lower subcutaneous fat index predicts bone metastasis in breast cancer	9
The overexpression of HOXC6 in LUSC and pan-squamous cell carcinomas indicates the coexistence of nuclear division regulatory mechanisms	9
miRNAs expression pattern and machine learning models elucidate risk for gastric GIST	9
Dysregulation of ECRG4 is associated with malignant properties and of prognostic importance in human gastric cancer	9
A novel disulfidptosis-related prognostic gene signature and experimental validation identify ACTN4 as a novel therapeutic target in lung adenocarcinoma	9
The combined detection of hematological indicators is used for the differential diagnosis of colorectal cancer and benign-colorectal lesions	9
Identification and validation of real hub genes in hepatocellular carcinoma based on weighted gene co-expression network analysis	8
Prognosis of keratinizing squamous cell carcinoma of the female reproductive system: A retrospective study	8
Deep learning approaches for breast cancer detection in histopathology images: A review	8
E2F1 transcriptionally regulates CCNA2 expression to promote triple negative breast cancer tumorigenicity	8
A simplified MyProstateScore2.0 for high-grade prostate cancer	8
Evaluation of the role of soluble B7-H3 in association with membrane B7-H3 expression in gastric adenocarcinoma	7
The prognostic significance of DDIT4 in endometrial cancer	7
Identification of potential core genes at single-cell level contributing to pathogenesis of pancreatic ductal adenocarcinoma through bioinformatics analysis	7
Uncovering the link between human endogenous retroviruses, inflammatory pathways, and gastric cancer development	7
Prognostic value of ALK overexpression and molecular abnormalities in high-grade serous ovarian carcinoma	7
Pan-TRK immunohistochemistry as screening tool for NTRK fusions: A diagnostic workflow for the identification of positive patients in clinical practice	7
Comparative proteomic analysis of exhaled breath condensate between lung adenocarcinoma and CT-detected benign pulmonary nodule patients	7
Prognostic value and gene regulatory network of CMSS1 in hepatocellular carcinoma	7
Prognostic characterization of the pyroptosis-related subtypes and tumor microenvironment infiltration in glioma	7
Multi-OMICs data analysis identifies molecular features correlating with tumor immunity in colon cancer	7
Personalized statistical learning algorithms to improve the early detection of cancer using longitudinal biomarkers	7
Retraction to: Knockdown of USP39 by lentivirus-mediated RNA interference suppresses the growth of oral squamous cell carcinoma	7
Blood endocan as a biomarker for breast cancer recurrence	7
Retraction to: Schizandrin A inhibits proliferation, migration and invasion of thyroid cancer cell line TPC-1 by down regulation of microRNA-429	7
External validation of CEA and CA125 prediction model for lymph node metastasis in endometrial cancer: A multi-institute cohort study	7
The ratio of lymphocyte/red blood cells and platelets/lymphocytes are predictive biomarkers for lymph node metastasis in patients with breast cancer	7
Association of 21-gene recurrence score and locoregional recurrence in early breast cancer patients	7
The association between pain and WHO grade of pancreatic neuroendocrine neoplasms: A multicenter study	7
The effect of chromosome abnormalities on expression of SnoRNA in radioresistant and radiosensitive cell lines after irradiation	7
Knockdown of MACC1 expression attenuates colorectal cancer cell glucose metabolism by suppressing GLUT4 membrane translocation	6
Retraction to: LINC01638 lncRNA promotes the proliferation, migration and invasion of prostate carcinoma cells by interacting with Notch1	6
Advances in SEMA3F regulation of clinically high-incidence cancers	6

CDT1 facilitates metastasis in prostate cancer and correlates with cell cycle regulation	6
Detection of hypermethylated BCAT1 and IKZF1 DNA in blood and tissues of colorectal, breast and prostate cancer patients	6
Combination detection of IgG- and IgA-related autoantibodies for the early diagnosis of gastric cancer	6
The protein-protein interaction network of intestinal gastric cancer patients reveals hub proteins with potential prognostic value	6
Tumour microbiota activities associated with local recurrence in ER + PR + breast cancer	6
A new immune-related gene signature predicts the prognosis and immune escape of bladder cancer	6
Upregulated mitosis-associated genes CENPE, CENPF, and DLGAP5 predict poor prognosis and chemotherapy resistance of Acute Myeloid Leukemia	6
Subcutaneous fat predicts bone metastasis in breast cancer: A novel multimodality-based deep learning model	6
Retraction to: MicroRNA-1246 inhibits cell invasion and epithelial mesenchymal transition process by targeting CXCR4 in lung cancer cells	6
Assessing the prognostic value of IMDC risk score for nivolumab-treated patients with renal cancer and malignant melanoma	6
Salivary DNA methylation markers for cancer of oral cavity	6
Hypermethylation of the BRCA2 gene promoter and its co-hypermethylation with the BRCA1 gene promoter in patients with breast cancer	6
Identification of a prognostic signature based on five ferroptosis-related genes for diffuse large B-cell lymphoma	6
Hsa_circ_0101308 adjusted by N6-methyladenosine (m 6 A) impacts chemo-resistance in cervical cancer via sponging miR-224	6
Serum CA19-9 as a predictor of incident metabolic syndrome in obese middle-aged and older men: A 9-year cohort study	6
Clinical powers of Aminoacyl tRNA Synthetase Complex Interacting Multifunctional Protein 1 (AIMP1) for head-neck squamous cell carcinoma	6
CmP signaling network unveils novel biomarkers for triple negative breast cancer in African American women	6
Non-invasive prediction of DCE-MRI radiomics model on CCR5 in breast cancer based on a machine learning algorithm	6
RANK in cancer-associated fibroblasts: A valuable prognostic determinant for metastasis in early-stage breast cancer patients	5
Internalization of extracellular double-stranded DNA as a potential marker of cancer stem cells in Epstein–Barr virus-induced B-cell lymphoma	5
The importance of biglycan, decorin and TGF-1 levels in the diagnosis of non-small cell lung cancer	5
PDCD2L overexpression represents an unfavorable prognostic marker and its inhibition shows promising therapeutic potential for gastric cancer	5
Retraction to: MicroRNA-152 inhibits tumor cell growth while inducing apoptosis via the transcriptional repression of cathepsin L in gastrointestinal stromal tumor	5
Diagnostic utility of lipocalin 2 and metalloproteinase 9 levels in early-stage endometrial cancer	5
A comprehensive analysis of mRNA expression profiles of Esophageal Squamous Cell Carcinoma reveals downregulation of Desmoglein 1 and crucial genomic targets	5
A novel cuproptosis-related lncRNA signature predicts the prognosis and immunotherapy for hepatocellular carcinoma	5
TUBB3 (βIII-tubulin) drives gastric cancer progression and poor prognosis by regulating cell cycle and invadopodia formation	5
Identification of metabolic biomarkers for diagnosis of epithelial ovarian cancer using internal extraction electrospray ionization mass spectrometry (iEESI-MS)	5
The association between albumin-globulin ratio (AGR) and survival in patients treated with immune checkpoint inhibitors	5
Radiomics and artificial intelligence for risk stratification of pulmonary nodules: Ready for primetime?	5
Comprehensive analysis of negatively correlated miRNA-mRNA regulatory pairs associated with microsatellite instability in colorectal cancer	5
Serum aspartate aminotransferase, a novel potential biomarker of prognosis in extranodal natural killer/T cell lymphoma, nasal type	5
Changes in subcellular localization of Lysyl-tRNA synthetase and the 67-kDa laminin receptor in epithelial ovarian cancer metastases	5
Pulmonary adenocarcinoma of low malignant potential defines indolent NSCLC associated with overdiagnosis in the national lung screening trial	5
Clinical significance of “S” isoform of DCLK1 in different gastric cancer subtypes using newly produced monoclonal antibody	5
Prognostic value of an eighteen-genes panel in acute myeloid leukemia by analyzing TARGET and TCGA databases	5
The prognostic and antitumor roles of key genes of ferroptosis in liver hepatocellular cancer and stomach adenocarcinoma	5
Erratum	5
Identification of RNA-binding protein RBMS3 as a potential biomarker for immunotherapy in bladder cancer	5
Prediction for recurrent non-muscle invasive bladder cancer	5
Development and validation of machine learning models for early diagnosis and prognosis of lung adenocarcinoma using miRNA expression profiles	4
Association of miR-21 and miR-335 to microsatellite instability and prognosis in stage III colorectal cancer	4
Evaluation of CDCP1 (CD318) and endoglin (CD105) expression as prognostic markers in acute myeloid leukemia	4
Differential gene expression analysis for osteosarcoma lung metastases	4
Estimated proportion of cancer deaths not addressed by current cancer screening efforts in the United States	4
Machine learning-driven gene expression profiling for lung cancer stage determination	4
Targeted proteomics for cancer biomarker verification and validation	4
Erratum	4
Prognostic impact of invariant natural killer T cells in solid and hematological tumors; systematic review and meta-analysis	4
Polyclonal plasma cell (PolyPC) signature as a key indicator for predicting the progression of MGUS to multiple myeloma	4
Expression and clinical significance of TYRP1, ABCB5, and MMP17 in sinonasal mucosal melanoma	4
Detection of leucine-rich alpha-2-glycoprotein 1 containing immunocomplexes in the plasma of lung cancer patients with epitope-specific mAbs	4
EMP3: A promising biomarker for tumor prognosis and targeted cancer therapy	4
miR-370 is better than miR-375 as a non-invasive diagnostic biomarker for pediatric acute myeloid leukemia patients	4
Elevated expression patterns of P-element Induced Wimpy Testis (PIWI) transcripts are potential candidate markers for Hepatocellular Carcinoma	4
Construct dysregulated miRNA-mRNA interaction networks to conjecture possible pathogenesis for Stomach adenocarcinomas	4
Predictive role of HPGD gene in carcinogenesis and immune environment monitoring in human cervical cancer	4
A clinical spectrum of resectable lung adenocarcinoma with micropapillary component (MPC) concurrently presenting as mixed ground-glass opacity nodules	4
Lidocaine inhibited migration of NSCLCA549 cells via the CXCR4 regulation	4
Identification of DNA methylation-regulated WEE1 with potential implications in prognosis and immunotherapy for low-grade glioma	4
Circulating tumor DNA (ctDNA) as a biomarker of response to therapy in advanced Hepatocellular carcinoma treated with Nivolumab	4
Thresholding of prominent biomarkers of breast cancer on overall survival using classification and regression tree	4
Capillary microsampling-based single-cell metabolomics by mass spectrometry and its applications in medicine and drug discovery	4
PDGFRB is a potential prognostic biomarker and correlated with immune infiltrates in gastric cancer	4
Immunological function and prognostic value of lymphoid-specific helicase in liver hepatocellular carcinoma	4
A computed tomography-based score indicative of lung cancer aggression (SILA) predicts lung adenocarcinomas with low malignant potential or vascular invasion	3
Aberrant STAT1 methylation as a non-invasive biomarker in blood of HCV induced hepatocellular carcinoma	3
Machine learning analyses of highly-multiplexed immunofluorescence identifies distinct tumor and stromal cell populations in primary pancreatic tumors1	3
PD-1 inhibitor combined with Docetaxel exerts synergistic anti-prostate cancer effect in mice by down-regulating the expression of PI3K/AKT/NFKB-P65/PD-L1 signaling pathway	3
Bioinformatics analysis of markers based on m6A related to prognosis combined with immune invasion of rectal adenocarcinoma	3
Retraction to: Knockdown of lncRNA CCAT2 inhibits endometrial cancer cells growth and metastasis via sponging miR-216b	3
Clinical correlations with EGFR circulating tumor DNA testing in all-stage lung adenocarcinoma	3
Machine learning methods revealed the roles of immune-metabolism related genes in immune infiltration, stemness, and prognosis of neuroblastoma	3
AhRR methylation contributes to disease progression in urothelial bladder cancer	3
Changes in the neutrophil to lymphocyte ratio as predictors of outcome in pediatric patients with central nervous system tumors undergoing surgical resection	3
Effects of methylation and imprinting expression of Insulin-like growth factor 2 gene in gastric cancer	3
Prognostic value of Talin-1 in renal cell carcinoma and its association with B7-H3	3
Overexpression of lncRNA TUG1 enhances the efficacy of DC-CIK immunotherapy in neuroblastoma in vitro and in vivo	3
Notice of retraction	3
Association of SIRT1 single gene nucleotide polymorphisms and serum SIRT1 levels with laryngeal squamous cell carcinoma patient survival rate	3

Exosome-delivered circular RNA DLGAP4 induces chemoresistance via miR-143-HK2 axis in neuroblastoma	3
An integrative approach toward identification and analysis of therapeutic targets involved in HPV pathogenesis with a focus on carcinomas	3
lncRNA ARAP1-AS1 enhances proliferation and impairs apoptosis of lymphoma cells by sponging miR-6867-5p	3
MicroRNA-204/CREB5 axis regulates vasculogenic mimicry in breast cancer cells	3
Hsa_circ_0002346 inhibits proliferation, invasion, and migration of breast cancer cells and promotes apoptosis: A novel potential biomarker for breast cancer	3
Spatial proteomics and transcriptomics characterization of tissue and multiple cancer types including decalcified marrow	3
CD133 is an independent predictive and prognostic marker in metastatic breast cancer	3
Exploring lipid metabolism-associated gene biomarkers and their regulatory mechanisms in nasopharyngeal carcinoma	3
Endothelial activation and stress index (EASIX) as a predictive biomarker in small cell lung cancer	3
Microbial biomarker development for detection and prognosis of early-stage non-small cell lung cancer	3
Expression of CD10 and CD15 in colorectal mucinous and signet ring adenocarcinomas and its relation to clinicopathological features and prognosis	3
Upregulation of MED7 was associated with progression in hepatocellular carcinoma	3
Multi-omics comprehensive analysis reveals the predictive value of N6-methyladenosine- related genes in prognosis and immune escape of bladder cancer	3
DNALI1 is a prognosis-related biomarker and correlates with immune infiltrates in low grade glioma	3
CD137L and colorectal cancer prognosis: Insights from clinical and TCGA data analysis	3
Curcumin increases crizotinib sensitivity through the inactivation of autophagy via epigenetic modulation of the miR-142-5p/Ulk1 axis in non-small cell lung cancer	2
Comprehensive analysis and establishment of a prognostic model based on non-genetic predictors in multiple myeloma1	2
Plasma checkpoint protein 1 (Chk1) as a potential diagnostic biomarker for opisthorchiasis and cholangiocarcinoma	2
The bioinformatics analysis of CD59 in Helicobacter pylori infected gastric cancer	2
KIF18A promotes cervical squamous cell carcinoma progression by activating the PI3K/AKT pathway through upregulation of CENPE	2
MKRN1/2 serve as tumor suppressors in renal clear cell carcinoma by regulating the expression of p53	2
Circulating microRNAs as molecular biomarkers for lung adenocarcinoma	2
Biomarkers and potential function analysis of triple-negative breast cancer screening based on bioinformatics	2
Bioinformatics screened of biomarkers for the prognosis of hepatocellular carcinoma	2
Association of single nucleotide polymorphism miRNA-146a (rs2910164) with increased predisposition to oral squamous cell carcinoma in central India population	2
Comparison of CINtec PLUS cytology and cobas HPV test for triaging Canadian patients with LSIL cytology referred to colposcopy: A two-year prospective study	2
Diagnostic and prognostic utility of TROP-2, SLP-2, and CXCL12 expression in papillary thyroid carcinoma	2
Downregulation of ASF1B inhibits tumor progression and enhances efficacy of cisplatin in pancreatic cancer	2
LINC01207 promotes the progression of non-small cell lung cancer via regulating ARHGAP11A by sponging miR-525-5p	2
Construction of a lncRNA-mediated ceRNA network and a genomic-clinicopathologic nomogram to predict survival for breast cancer patients	2
Identification of urinary biomarkers of colorectal cancer: Towards the development of a colorectal screening test in limited resource settings	2
Urinary VOCs as biomarkers of early stage lung tumour development in mice	2
The change of soluble programmed cell death ligand-1 (sPD-L1): A new predictor of prognosis in hypopharyngeal squamous cell carcinoma patients treated with radiotherapy	2
Circ_0049271 targets the miR-1197/PTRF axis to attenuate the malignancy of osteosarcoma	2
Vitamin D receptor polymorphisms associate with the efficacy and toxicity of radioiodine-131 therapy in patients with differentiated thyroid cancer	2
Predictive value of preoperative inflammatory markers and serum CA 125 level for surgical outcome in Indonesian women with epithelial ovarian cancer	2
Discrepancies of RET gene and risk of differentiated thyroid carcinoma	2
Carboxypeptidase E mRNA: Overexpression predicts recurrence and death in lung adenocarcinoma cancer patients	2
Effect of D-mannose on Philadelphia chromosome-positive leukemia cells	2
Identification of Hub genes with prognostic values in colorectal cancer by integrated bioinformatics analysis	2
Pan-cancer transcriptomic data of ABI1 transcript variants and molecular constitutive elements identifies novel cancer metastatic and prognostic biomarkers	2
Screening of key methylation-driven genes CDO1 in breast cancer based on WGCNA	2
Elevated expression of TNFRSF4 impacts immune cell infiltration and gene mutation in hepatocellular carcinoma	2
Association of FBXW11 levels with tumor development and prognosis in chondrosarcoma	2
Characterization of a novel four-miRNA signature in papillary thyroid carcinoma: Integrating molecular profiling, hormonal regulation, and diagnostic implications in populations with rising PTC incide	2
Delta-like ligand 4 level in colorectal cancer is associated with tumor aggressiveness and clinical outcome	2
Long non-coding RNAs PTENP1, GNG12-AS1, MAGI2-AS3 and MEG3 as tumor suppressors in breast cancer and their associations with clinicopathological parameters	2
Knockdown of HSF1 inhibits invasion, metastasis, and proliferation of endometrial carcinoma cells while promoting apoptosis	2
Rho GTPase-activating protein 4 is upregulated in Kidney Renal Clear Cell Carcinoma and associated with poor prognosis and immune infiltration	2
Circulating microRNA as potential diagnostic and prognostic biomarkers of well-differentiated thyroid cancer: A review article	2
MiR-224 promotes lymphatic metastasis by targeting ANGPTL1 in non-small-cell lung carcinoma	2
Combined HPV 16 E2 and L1 methylation predict response to treatment with cidofovir and imiquimod in patients with vulval intraepithelial neoplasia	2
Systematic exploration of prognostic alternative splicing events related to tumor immune microenvironment of Clear Cell Renal Cell Carcinoma	2
The tumor microenvironment and prognostic role of autophagy- and immune-related genes in bladder cancer	2
The clinical value of a nomogram constructed from CEA, CA199, PT, FIB, tumor differentiation and TNM stage in colorectal cancer	2
Granzymes expression patterns predict immunotherapy response and identify the heterogeneity of CD8+ T cell subsets	2
Toll-like receptor 3 is a potential prognosis marker and associated with immune infiltration in stomach adenocarcinoma	2
LncRNA STK4 antisense RNA 1 (STK4-AS1) promoted osteosarcoma by inhibiting p53 expression	2
Radiomics model of 18F-FDG PET/CT imaging for predicting disease-free survival of early-stage uterine cervical squamous cancer	2
Liquid biopsy in clinical outcomes and detection of T790M mutation in metastatic non-small cell lung cancer after progression to EGFR-TKI	2
Profile of soluble factors in pleural effusions predict prognosis in mesothelioma	2
Alternative polyadenylation mechanism links secreted phosphoprotein 1 gene to glioblastoma	2