Cancer Biomarkers

Article	Citations
Circulating microRNA-762 upregulation in colorectal cancer may be accompanied by Wnt-1/β-catenin signaling	51
The clinical significance and function of EGFR mutation in TKI treatments of NSCLC patients	50
RAB27B expression in pancreatic cancer is predictive of poor survival but good response to chemotherapy	47
Preoperative albumin-alkaline phosphatase ratio affects the prognosis of patients undergoing hepatocellular carcinoma surgery	31
Individual recombinant repeats of MUC16 display variable binding to CA125 antibodies	27
Involvement of FAM170B-AS1, hsa-miR-1202, and hsa-miR-146a-5p in breast cancer	24
The effect of low-intensity resistance exercise training on Serum tumor biomarkers and quality of life in women with breast cancer: A randomized controlled trial	22
miR-383-5p serves as a tumor suppressor in bladder cancer by suppressing PI3K/AKT signaling pathway	22
Risk stratification of pancreatic cancer by a blood test for apolipoprotein A2-isoforms	22
KIAA1429-mediated RXFP1 attenuates non-small cell lung cancer tumorigenesis via N6-methyladenosine modification	19
Integrative analysis of histone acetyltransferase KAT2A in human cancer	17
KLF5 inhibits the migration and invasion in cervical cancer cell lines by regulating SNAI1	16
Machine learning identifies a 5-serum cytokine panel for the early detection of chronic atrophy gastritis patients	15
Circulating and tissue miR-100 acts as a potential diagnostic biomarker for cervical cancer	15
Association analysis of genetic variants in the ghrelin and tumor necrosis factor α genes and the risk for non-Hodgkin’s lymphoma in Kuwaitis	15
Methylation of FBN1, SPG20, ITF2, RUNX3, SNCA, MLH1, and SEPT9 genes in circulating cell-free DNA as biomarkers of colorectal cancer	15
YTHDF1 amplification is correlated with worse outcome and lower immune cell infiltrations in breast cancer	14
Impact of the peripheral blood inflammatory indices and modified nomogram-revised risk index on survival of Extranodal Nasal-Type Natural Killer/T-Cell lymphoma	14
Identification of a novel necroptosis-related LncRNA signature for prognostic prediction and immune response in oral squamous cell carcinoma	14
Erratum to: Annexin A5 overexpression might suppress proliferation and metastasis of human uterine cervical carcinoma cells	13
US-Japan collaboration: Collaboration across international boundary	13
Aquaporin-8 is a novel marker for progression of human cervical cancer cells	13
Multi-omics pan-cancer analysis of monocyte to macrophage differentiation-associated (MMD) and its significance in hepatocellular carcinoma	12
High TCTA expression is an adverse prognostic biomarker in acute myeloid leukemia	12
Identification of candidate biomarkers and prognostic analysis of recurrence in colorectal cancer	12

CHRDL1, NEFH, TAGLN and SYNM as novel diagnostic biomarkers of benign prostatic hyperplasia and prostate cancer	12
Identification of TNFRSF1A as a potential biomarker for osteosarcoma	12
GINS2 promotes the progression of human HNSCC by altering RRM2 expression	12
Investigating whether exosomal miR-205-5p derived from tongue squamous cell carcinoma cells stimulates the angiogenic activity of HUVECs by targeting AMOT	12
Volume doubling time and radiomic features predict tumor behavior of screen-detected lung cancers	12
TET-2 mutations predict poor outcomes and are associated with unfavorable clinical-biological features in PTCL, not otherwise specified and angioimmunoblastic T-cell lymphoma in Brazilian patients	12
Analysis of clinical significance and molecular characteristics of methionine metabolism and macrophage-related patterns in hepatocellular carcinoma based on machine learning	12
Down-regulated MiRNA 29-b as a diagnostic marker in colorectal cancer and its correlation with ETV4 and Cyclin D1 immunohistochemical expression	11
CPT1B, a metabolic molecule, is also an independent risk factor in CN-AML	11
Albumin-bilirubin score predicts trastuzumab resistance in HER2-positive breast cancer	11
A pilot study to troubleshoot quality control metrics when assessing circulating miRNA expression data reproducibility across study sites	11
From discovery to clinical implementation of a pancreatic blood biomarker, apolipoprotein A2 isoform	10
A risk model based on signature genes predicts prognosis and associates with tumor immunity, drug sensitivity in breast cancer	10
EGFR, HLA-G, CD70, c-MET, and NY-ESO1 as potential biomarkers in high grade epithelial ovarian carcinoma	10
miRNAs expression pattern and machine learning models elucidate risk for gastric GIST	10
Machine learning reveals the role of telomerase activation-related genes in the prognosis of neuroblastoma	10
Expression of serum HMGB1, SAA, and TSGF in patients with colon cancer and the value of prognostic assessment	10
Assessing the clinical utility of biomarkers using the intervention probability curve (IPC)	10
Dysregulation of ECRG4 is associated with malignant properties and of prognostic importance in human gastric cancer	9
Identification of prognostic biomarkers among ICAMs in the breast cancer microenvironment	9
Lower subcutaneous fat index predicts bone metastasis in breast cancer	9
TRB CDR3-cancer testis antigen chemical complementarity scoring for identifying productive immune responses in renal cell carcinoma	9
The combined detection of hematological indicators is used for the differential diagnosis of colorectal cancer and benign-colorectal lesions	9
A novel disulfidptosis-related prognostic gene signature and experimental validation identify ACTN4 as a novel therapeutic target in lung adenocarcinoma	9
Identification and validation of real hub genes in hepatocellular carcinoma based on weighted gene co-expression network analysis	9
ELAPOR1 suppresses tumor progression in colorectal cancer and indicates favorable prognosis	9
Deep learning approaches for breast cancer detection in histopathology images: A review	9
E2F1 transcriptionally regulates CCNA2 expression to promote triple negative breast cancer tumorigenicity	9
A simplified MyProstateScore2.0 for high-grade prostate cancer	8
Evaluation of the role of soluble B7-H3 in association with membrane B7-H3 expression in gastric adenocarcinoma	8
Identification of potential core genes at single-cell level contributing to pathogenesis of pancreatic ductal adenocarcinoma through bioinformatics analysis	8
Multi-OMICs data analysis identifies molecular features correlating with tumor immunity in colon cancer	8
The prognostic significance of DDIT4 in endometrial cancer	8
Prognosis of keratinizing squamous cell carcinoma of the female reproductive system: A retrospective study	8
Prognostic characterization of the pyroptosis-related subtypes and tumor microenvironment infiltration in glioma	8
A panel of epigenetically dysregulated Wnt signaling pathway genes for non-invasive diagnosis of pediatric acute lymphoblastic leukemia	8
Evaluation of a 92 multiplex protein panel in detection of colorectal cancer and high-risk adenoma in 784 symptomatic individuals	8
External validation of CEA and CA125 prediction model for lymph node metastasis in endometrial cancer: A multi-institute cohort study	8
CA125 normalization within 60 days as an independent prognostic factor for patients with advanced epithelial ovarian cancer	8
Prognostic value and gene regulatory network of CMSS1 in hepatocellular carcinoma	8
Knockdown CYP2S1 inhibits lung cancer cells proliferation and migration	8
Role of Tim-3 in regulating tumorigenesis, inflammation, and antitumor immunity therapy	7
Prognostic value of ALK overexpression and molecular abnormalities in high-grade serous ovarian carcinoma	7
Personalized statistical learning algorithms to improve the early detection of cancer using longitudinal biomarkers	7
Comparative proteomic analysis of exhaled breath condensate between lung adenocarcinoma and CT-detected benign pulmonary nodule patients	7
The ratio of lymphocyte/red blood cells and platelets/lymphocytes are predictive biomarkers for lymph node metastasis in patients with breast cancer	7
Retraction to: Knockdown of USP39 by lentivirus-mediated RNA interference suppresses the growth of oral squamous cell carcinoma	7
The association between pain and WHO grade of pancreatic neuroendocrine neoplasms: A multicenter study	7
Retraction to: Schizandrin A inhibits proliferation, migration and invasion of thyroid cancer cell line TPC-1 by down regulation of microRNA-429	7
Uncovering the link between human endogenous retroviruses, inflammatory pathways, and gastric cancer development	7

Association of 21-gene recurrence score and locoregional recurrence in early breast cancer patients	7
The effect of chromosome abnormalities on expression of SnoRNA in radioresistant and radiosensitive cell lines after irradiation	7
Blood endocan as a biomarker for breast cancer recurrence	7
Detection of hypermethylated BCAT1 and IKZF1 DNA in blood and tissues of colorectal, breast and prostate cancer patients	6
Clinical powers of Aminoacyl tRNA Synthetase Complex Interacting Multifunctional Protein 1 (AIMP1) for head-neck squamous cell carcinoma	6
Salivary DNA methylation markers for cancer of oral cavity	6
CDT1 facilitates metastasis in prostate cancer and correlates with cell cycle regulation	6
Clinical implication and prognostic significance of FLT3-ITD and ASXL1 mutations in Egyptian AML patients: A single-center study	6
Serum CA19-9 as a predictor of incident metabolic syndrome in obese middle-aged and older men: A 9-year cohort study	6
Retraction to: MicroRNA-1246 inhibits cell invasion and epithelial mesenchymal transition process by targeting CXCR4 in lung cancer cells	6
Assessing the prognostic value of IMDC risk score for nivolumab-treated patients with renal cancer and malignant melanoma	6
Hypermethylation of the BRCA2 gene promoter and its co-hypermethylation with the BRCA1 gene promoter in patients with breast cancer	6
Pan-TRK immunohistochemistry as screening tool for NTRK fusions: A diagnostic workflow for the identification of positive patients in clinical practice	6
Knockdown of MACC1 expression attenuates colorectal cancer cell glucose metabolism by suppressing GLUT4 membrane translocation	6
CmP signaling network unveils novel biomarkers for triple negative breast cancer in African American women	6
Subcutaneous fat predicts bone metastasis in breast cancer: A novel multimodality-based deep learning model	6
Non-invasive prediction of DCE-MRI radiomics model on CCR5 in breast cancer based on a machine learning algorithm	6
The protein-protein interaction network of intestinal gastric cancer patients reveals hub proteins with potential prognostic value	6
Comprehensive analysis of negatively correlated miRNA-mRNA regulatory pairs associated with microsatellite instability in colorectal cancer	5
Retraction to: LINC01638 lncRNA promotes the proliferation, migration and invasion of prostate carcinoma cells by interacting with Notch1	5
Advances in SEMA3F regulation of clinically high-incidence cancers	5
The prognostic and antitumor roles of key genes of ferroptosis in liver hepatocellular cancer and stomach adenocarcinoma	5
Hsa_circ_0101308 adjusted by N6-methyladenosine (m 6 A) impacts chemo-resistance in cervical cancer via sponging miR-224	5
Pulmonary adenocarcinoma of low malignant potential defines indolent NSCLC associated with overdiagnosis in the national lung screening trial	5
Identification of a prognostic signature based on five ferroptosis-related genes for diffuse large B-cell lymphoma	5
The miRNA content of circulating exosomes in DLBCL patients and in vitro influence of DLBCL-derived exosomes on miRNA expression of healthy B-cells from peripheral blood	5
Identification of metabolic biomarkers for diagnosis of epithelial ovarian cancer using internal extraction electrospray ionization mass spectrometry (iEESI-MS)	5
Upregulated mitosis-associated genes CENPE, CENPF, and DLGAP5 predict poor prognosis and chemotherapy resistance of Acute Myeloid Leukemia	5
Internalization of extracellular double-stranded DNA as a potential marker of cancer stem cells in Epstein–Barr virus-induced B-cell lymphoma	5
Retraction to: MicroRNA-152 inhibits tumor cell growth while inducing apoptosis via the transcriptional repression of cathepsin L in gastrointestinal stromal tumor	5
Relevance of plasma bone marrow Activin-A and CXCL-12 concentration levels as a biomarker in acute myeloid leukemia	5
A new immune-related gene signature predicts the prognosis and immune escape of bladder cancer	5
The association between albumin-globulin ratio (AGR) and survival in patients treated with immune checkpoint inhibitors	5
Prognostic value of an eighteen-genes panel in acute myeloid leukemia by analyzing TARGET and TCGA databases	5
The importance of biglycan, decorin and TGF-1 levels in the diagnosis of non-small cell lung cancer	5
A novel cuproptosis-related lncRNA signature predicts the prognosis and immunotherapy for hepatocellular carcinoma	4
Estimated proportion of cancer deaths not addressed by current cancer screening efforts in the United States	4
Thresholding of prominent biomarkers of breast cancer on overall survival using classification and regression tree	4
PDGFRB is a potential prognostic biomarker and correlated with immune infiltrates in gastric cancer	4
Detection of leucine-rich alpha-2-glycoprotein 1 containing immunocomplexes in the plasma of lung cancer patients with epitope-specific mAbs	4
Capillary microsampling-based single-cell metabolomics by mass spectrometry and its applications in medicine and drug discovery	4
Changes in subcellular localization of Lysyl-tRNA synthetase and the 67-kDa laminin receptor in epithelial ovarian cancer metastases	4
Identification of RNA-binding protein RBMS3 as a potential biomarker for immunotherapy in bladder cancer	4
Diagnostic utility of lipocalin 2 and metalloproteinase 9 levels in early-stage endometrial cancer	4
RANK in cancer-associated fibroblasts: A valuable prognostic determinant for metastasis in early-stage breast cancer patients	4
EMP3: A promising biomarker for tumor prognosis and targeted cancer therapy	4
SPARC regulates ferroptosis induced by sorafenib in human hepatocellular carcinoma	4
Targeted proteomics for cancer biomarker verification and validation	4
Genetic polymorphisms of Cathepsin B are associated with gastric cancer risk and prognosis in a Chinese population	4
Differential gene expression analysis for osteosarcoma lung metastases	4
Lidocaine inhibited migration of NSCLCA549 cells via the CXCR4 regulation	4
Impact of detecting plasma EGFR mutations with ultrasensitive liquid biopsy in outcomes of NSCLC patients treated with first- or second-generation EGFR-TKIs	4
Prediction for recurrent non-muscle invasive bladder cancer	4
Radiomics and artificial intelligence for risk stratification of pulmonary nodules: Ready for primetime?	4
Clinical significance of “S” isoform of DCLK1 in different gastric cancer subtypes using newly produced monoclonal antibody	4
miR-370 is better than miR-375 as a non-invasive diagnostic biomarker for pediatric acute myeloid leukemia patients	4
Quantitative analysis of KLF4 and SOX2 expression in oral carcinomas reveals independent association with oral tongue subsite location and histological grade	4
Evaluation of CDCP1 (CD318) and endoglin (CD105) expression as prognostic markers in acute myeloid leukemia	4
Circulating tumor DNA (ctDNA) as a biomarker of response to therapy in advanced Hepatocellular carcinoma treated with Nivolumab	4
Elevated expression patterns of P-element Induced Wimpy Testis (PIWI) transcripts are potential candidate markers for Hepatocellular Carcinoma	4
Identification of DNA methylation-regulated WEE1 with potential implications in prognosis and immunotherapy for low-grade glioma	4
A comprehensive analysis of mRNA expression profiles of Esophageal Squamous Cell Carcinoma reveals downregulation of Desmoglein 1 and crucial genomic targets	4
Expression and clinical significance of TYRP1, ABCB5, and MMP17 in sinonasal mucosal melanoma	4
Serum aspartate aminotransferase, a novel potential biomarker of prognosis in extranodal natural killer/T cell lymphoma, nasal type	4
Erratum	4
Machine learning methods revealed the roles of immune-metabolism related genes in immune infiltration, stemness, and prognosis of neuroblastoma	3
Effects of methylation and imprinting expression of Insulin-like growth factor 2 gene in gastric cancer	3
A computed tomography-based score indicative of lung cancer aggression (SILA) predicts lung adenocarcinomas with low malignant potential or vascular invasion	3
Endothelial activation and stress index (EASIX) as a predictive biomarker in small cell lung cancer	3
The predictive potential of Neuronatin for neoadjuvant chemotherapy of breast cancer	3
Multi-omics comprehensive analysis reveals the predictive value of N6-methyladenosine- related genes in prognosis and immune escape of bladder cancer	3
An integrative approach toward identification and analysis of therapeutic targets involved in HPV pathogenesis with a focus on carcinomas	3
Notice of retraction	3
Upregulation of MED7 was associated with progression in hepatocellular carcinoma	3
A clinical spectrum of resectable lung adenocarcinoma with micropapillary component (MPC) concurrently presenting as mixed ground-glass opacity nodules	3
Prognostic impact of invariant natural killer T cells in solid and hematological tumors; systematic review and meta-analysis	3
Immunological function and prognostic value of lymphoid-specific helicase in liver hepatocellular carcinoma	3
Hsa_circ_0002346 inhibits proliferation, invasion, and migration of breast cancer cells and promotes apoptosis: A novel potential biomarker for breast cancer	3
MicroRNA-204/CREB5 axis regulates vasculogenic mimicry in breast cancer cells	3
Erratum	3

Spatial proteomics and transcriptomics characterization of tissue and multiple cancer types including decalcified marrow	3
Association of SIRT1 single gene nucleotide polymorphisms and serum SIRT1 levels with laryngeal squamous cell carcinoma patient survival rate	3
Changes in the neutrophil to lymphocyte ratio as predictors of outcome in pediatric patients with central nervous system tumors undergoing surgical resection	3
Predictive role of HPGD gene in carcinogenesis and immune environment monitoring in human cervical cancer	3
Retraction to: Knockdown of lncRNA CCAT2 inhibits endometrial cancer cells growth and metastasis via sponging miR-216b	3
AhRR methylation contributes to disease progression in urothelial bladder cancer	3
Development and validation of machine learning models for early diagnosis and prognosis of lung adenocarcinoma using miRNA expression profiles	3
Targeting PKM2 promotes chemosensitivity of breast cancer cells in vitro and in vivo	3
DNALI1 is a prognosis-related biomarker and correlates with immune infiltrates in low grade glioma	3
Polyclonal plasma cell (PolyPC) signature as a key indicator for predicting the progression of MGUS to multiple myeloma	3
Expression of CD10 and CD15 in colorectal mucinous and signet ring adenocarcinomas and its relation to clinicopathological features and prognosis	3
Bioinformatics analysis of markers based on m6A related to prognosis combined with immune invasion of rectal adenocarcinoma	3
Microbial biomarker development for detection and prognosis of early-stage non-small cell lung cancer	3
Aberrant STAT1 methylation as a non-invasive biomarker in blood of HCV induced hepatocellular carcinoma	3
Clinical correlations with EGFR circulating tumor DNA testing in all-stage lung adenocarcinoma	3
Exosome-delivered circular RNA DLGAP4 induces chemoresistance via miR-143-HK2 axis in neuroblastoma	3
PD-1 inhibitor combined with Docetaxel exerts synergistic anti-prostate cancer effect in mice by down-regulating the expression of PI3K/AKT/NFKB-P65/PD-L1 signaling pathway	3
lncRNA ARAP1-AS1 enhances proliferation and impairs apoptosis of lymphoma cells by sponging miR-6867-5p	3
Erratum	3
Association of miR-21 and miR-335 to microsatellite instability and prognosis in stage III colorectal cancer	3
Construct dysregulated miRNA-mRNA interaction networks to conjecture possible pathogenesis for Stomach adenocarcinomas	3
Prognostic value of Talin-1 in renal cell carcinoma and its association with B7-H3	2
MiR-224 promotes lymphatic metastasis by targeting ANGPTL1 in non-small-cell lung carcinoma	2
Suppression effect of a dual cancer-specific oncolytic adenovirus on luciferase-labeled human melanoma cells in vitro and in vivo	2
Identification of immune cell infiltration pattern and related critical genes in metastatic castration-resistant prostate cancer by bioinformatics analysis	2
Carboxypeptidase E mRNA: Overexpression predicts recurrence and death in lung adenocarcinoma cancer patients	2
Systematic exploration of prognostic alternative splicing events related to tumor immune microenvironment of Clear Cell Renal Cell Carcinoma	2
LncRNA STK4 antisense RNA 1 (STK4-AS1) promoted osteosarcoma by inhibiting p53 expression	2
Comparison of CINtec PLUS cytology and cobas HPV test for triaging Canadian patients with LSIL cytology referred to colposcopy: A two-year prospective study	2
Integrative genome wide analysis of protein tyrosine phosphatases identifies CDC25C as prognostic and predictive marker for chemoresistance in breast cancer	2
Construction of a lncRNA-mediated ceRNA network and a genomic-clinicopathologic nomogram to predict survival for breast cancer patients	2
Rho GTPase-activating protein 4 is upregulated in Kidney Renal Clear Cell Carcinoma and associated with poor prognosis and immune infiltration	2
Circulating microRNAs as molecular biomarkers for lung adenocarcinoma	2
Screening of key methylation-driven genes CDO1 in breast cancer based on WGCNA	2
Overexpression of lncRNA TUG1 enhances the efficacy of DC-CIK immunotherapy in neuroblastoma in vitro and in vivo	2
Pan-cancer transcriptomic data of ABI1 transcript variants and molecular constitutive elements identifies novel cancer metastatic and prognostic biomarkers	2
The change of soluble programmed cell death ligand-1 (sPD-L1): A new predictor of prognosis in hypopharyngeal squamous cell carcinoma patients treated with radiotherapy	2
Exploring lipid metabolism-associated gene biomarkers and their regulatory mechanisms in nasopharyngeal carcinoma	2
Plasma checkpoint protein 1 (Chk1) as a potential diagnostic biomarker for opisthorchiasis and cholangiocarcinoma	2
CD133 is an independent predictive and prognostic marker in metastatic breast cancer	2
The clinical value of a nomogram constructed from CEA, CA199, PT, FIB, tumor differentiation and TNM stage in colorectal cancer	2
The bioinformatics analysis of CD59 in Helicobacter pylori infected gastric cancer	2
Circ_0049271 targets the miR-1197/PTRF axis to attenuate the malignancy of osteosarcoma	2
Bioinformatics screened of biomarkers for the prognosis of hepatocellular carcinoma	2
Identification of Hub genes with prognostic values in colorectal cancer by integrated bioinformatics analysis	2
MKRN1/2 serve as tumor suppressors in renal clear cell carcinoma by regulating the expression of p53	2
KIF18A promotes cervical squamous cell carcinoma progression by activating the PI3K/AKT pathway through upregulation of CENPE	2
Discrepancies of RET gene and risk of differentiated thyroid carcinoma	2
Long non-coding RNAs PTENP1, GNG12-AS1, MAGI2-AS3 and MEG3 as tumor suppressors in breast cancer and their associations with clinicopathological parameters	2
Comprehensive analysis and establishment of a prognostic model based on non-genetic predictors in multiple myeloma1	2
Vitamin D receptor polymorphisms associate with the efficacy and toxicity of radioiodine-131 therapy in patients with differentiated thyroid cancer	2
Circulating microRNA as potential diagnostic and prognostic biomarkers of well-differentiated thyroid cancer: A review article	2
The tumor microenvironment and prognostic role of autophagy- and immune-related genes in bladder cancer	2
Notice of retraction	2
POM121 promotes proliferation and metastasis in non-small-cell lung cancer through TGF-β/SMAD and PI3K/AKT pathways	2
Association between baseline Controlling Nutritional Status score and clinical outcomes of patients with multiple myeloma	2
Machine learning analyses of highly-multiplexed immunofluorescence identifies distinct tumor and stromal cell populations in primary pancreatic tumors1	2
Profile of soluble factors in pleural effusions predict prognosis in mesothelioma	2
Usefulness of protein-based salivary markers in the diagnosis of oral potentially malignant disorders: A systematic review and meta-analysis	2
Prognostic and predictive significance of the tumor microenvironment in hepatocellular carcinoma	2
Granzymes expression patterns predict immunotherapy response and identify the heterogeneity of CD8+ T cell subsets	2
Effect of D-mannose on Philadelphia chromosome-positive leukemia cells	2
Association of endocan expression with clinicopathological prognostic parameters in breast carcinoma	2
Combined HPV 16 E2 and L1 methylation predict response to treatment with cidofovir and imiquimod in patients with vulval intraepithelial neoplasia	2
Biomarkers and potential function analysis of triple-negative breast cancer screening based on bioinformatics	2
IGF-1R depletion sensitizes colon cancer cell lines to radiotherapy	2
Toll-like receptor 3 is a potential prognosis marker and associated with immune infiltration in stomach adenocarcinoma	2
Association of single nucleotide polymorphism miRNA-146a (rs2910164) with increased predisposition to oral squamous cell carcinoma in central India population	2
Diagnostic and prognostic utility of TROP-2, SLP-2, and CXCL12 expression in papillary thyroid carcinoma	2
Erratum	2
Predictive value of preoperative inflammatory markers and serum CA 125 level for surgical outcome in Indonesian women with epithelial ovarian cancer	2
Epigenetically-regulated serum GAS5 as a potential biomarker for patients with chronic hepatitis B virus infection	2