Recent Patents on Anti-Cancer Drug Discovery

Article	Citations
Acknowledgement to Contributors	47
Acknowledgement to Reviewers	28
Advanced Strategies of CAR-T Cell Therapy in Solid Tumors and Hematological Malignancies	26
Research Progress on the Anticancer Activity of Plant Polysaccharides	24
Current Prospects for Adrenocortical Carcinoma Pharmacotherapy	22
High Expression of MYL9 Indicates Poor Clinical Prognosis of Epithelial Ovarian Cancer	20
L-Selenomethylselenocysteine Exerts Inhibitory Effects on the Progressionof Esophageal Cancer by Targeting the PI3K/AKT Signaling Pathway	19
Comprehensive Genomic Analysis of Puerarin in Inhibiting Bladder Urothelial Carcinoma Cell Proliferation and Migration	18
Patent Selections	16
Statin Use and Hepatocellular Carcinoma Risk: A Comprehensive Meta-Analysis and Systematic Review	16
Radiotherapy Enhancing and Radioprotective Properties of Berberine: A Systematic Review	16
Nanomaterials for Diagnosis and Treatment of Lung Cancer: A Review of Recent Patents	15
Bioinformatic Analysis and Experimental Validation of HMGA2-AS1 as a Prognostic Biomarker Associated with Immune Infiltration in Gastric Cancer	15
Santacruzamate A Compositions, Analogs and Methods of Use: A Patent Evaluation of WO 2014/018913 (A2)	15
Protective Assessment of Novel (BNC Formulation) against Brain Tumor	15
The Prognostic Role of Interferon Gamma-inducible Protein 30 in ClearCell Renal Cell Carcinoma with Immune Infiltrates	14
The Present State and Potential Applications of Artificial Intelligence in Cancer Diagnosis and Treatment	14
The Application of Nanotechnology in Immunotherapy based Combinations for Cancer Treatment	14
Network Pharmacology-based Prediction and Verification of Shikonin for Treating Colorectal Cancer	13
Alpha-solanine Anti-tumor Effects in Non-small Cell Lung Cancer Through Regulating the Energy Metabolism Pathway	13
Prognostic Value of Fatty Acid Metabolism-related Genes in Patients with Bladder Cancer	13
Oral Metronomic Chemotherapy in Nasopharyngeal Carcinoma withRadiotherapy Interruptions: A Lesson Learned from the Lockdown Due toCOVID-19	13
Vitexin's Role in Colon Cancer Apoptosis: AMPK/mTOR PathwayModulation Explored Through Experimental and ComputationalApproaches	11
Regulating Lipid Metabolism via Mitochondrial Dynamics in Tongue Squamous Cell Carcinoma Cancer Stem Cells	11
Integrated Single-cell and Bulk RNA Sequencing Analysis Cross Talk between Ferroptosis-related Genes and Prognosis in Oral Cavity Squamous Cell Carcinoma	11

USP31 Activates the Wnt/β-catenin Signaling Pathway and Promotes Gastric Cancer Cell Proliferation, Invasion and Migration	11
Acknowledgement To Reviewers	11
Self-immolative Linkers in Prodrugs and Antibody Drug Conjugates in Cancer Treatment	11
Bioinformatics Analysis of Key Genes Associated with Resistance to the Combination of Bevacizumab and Pemetrexed Chemotherapy in Non-small Cell Lung Cancer	11
Survival Benefits of Ganoderma Lucidum in Early-stage Triple-negative Breast Cancer: A Real World Study	10
Predictive Modelling of Overall Survival in Adult Patients with Primary Diffuse Large B-cell Lymphoma of the Breast Using the Surveillance, Epidemiology, and End Results (SEER) Database	10
Meet the Editorial Board Member	10
Patent Selections	10
The Causal Effects of Cholelithiasis on Acute Pancreatitis and Pancreatic Cancer: A Large Sample Size Mendelian Randomization Analysis	10
Prospective Challenges for Patenting and Clinical Trials of Anticancer Compounds from Natural Products: Coherent Review	10
Intracholecystic Papillary-tubular Neoplasm (ICPN) of the Gallbladder: A Case Report Focusing on an Unexpected Pathological Finding	10
Bourgeoning Cancer Targets	10
Mechanisms of Anti-PD Therapy Resistance in Digestive System Neoplasms	10
Patent Selections	10
Screening of Candidate Inflammatory Markers of Epithelial Cells in Hepatocellular Carcinoma based on Integration Analysis of TCGA/ICGC Databases and Single-cell Sequencing	10
SSPH I, A Novel Anti-cancer Saponin, Inhibits EMT and Invasion and Migration of NSCLC by Suppressing MAPK/ERK1/2 and PI3K/AKT/ mTOR Signaling Pathways	9
lncRNA H22954 Inhibits Angiogenesis in Acute Myeloid Leukemia through a PDGFA-dependent Mechanism	9
Puerarin: An Anticancer and Anti-Inflammatory Agent	9
Construction and Identification of a Human Colorectal Adenoma Epithelial Cell Line by SV40 Large T-antigen Transfection	9
Ubiquitination-related Gene UBTD1 Mediates Poor Prognosis of Colorectal Cancer and Affects Colorectal Cancer Cell Proliferation and Ferroptosis	9
Targeting the Key Signaling Pathways in Breast Cancer: From Molecular Mechanism to Therapeutic Interventions	8
Natural STAT3 Inhibitors for Cancer Treatment: A Comprehensive Literature Review	8
Circular RNA NF1-419 Inhibits Proliferation and Induces Apoptosis by Regulating Lipid Metabolism in Astroglioma Cells	8
The m 6 A Reader IGF2BP2 Promotes Oral Squamous Cell CarcinomaProgression by Maintaining UCA1 Stability	8
Application of Nano Drug Delivery System (NDDS) in Cancer Therapy: A Perspective	8
Metallodrugs as Anticancer Chemotherapeutics and Diagnostic Agents: A Critical Patent Review (2010-2020)	8
Fatty Acid Synthase (FASN): A Patent Review Since 2016-Present	7
Exploring the Anticancer Potentials of Polyphenols: A Comprehensive Review of Patents in the Last Five Years	7
Patent Selections	7
The Synergistic Effect of Ruthenium Complex Δ-Ru1 and Doxorubicin in a Mouse Breast Cancer Model	7
Adverse Effects of Gefitinib on Skin and Colon in a Lung Cancer Mouse Model	7
Advances in the Treatment of Chronic Myeloid Leukemia	7
UBE2L3 Suppresses Oxidative Stress-regulated Necroptosis to Accelerate Osteosarcoma Progression	7
Preface	7
Aucubin Inhibits Liver Cancer via HMGB1-mediated Inactivation of the PI3K/AKT/mTOR Signaling Pathway	7
The FJQR Has Synergistic Effect with Fluoropyrimidine in the Maintenance Treatment for HER-2 Negative Gastric Cancer	7
Prognostic and Therapeutic Values of Autophagy-related Genes in Triple-negative Breast Cancer	7
Targeted Regulation of Osteoblasts and Osteoclasts in Osteosarcoma Patients by CSF3R Receptor Inhibition of Osteolysis Caused by Tumor Inflammation Based on Transcriptional Spectrum Analysis and Drug	7
Patent Selections	6
pH-responsive Sulfated Hyaluronic Acid Nanoparticles Targeting Tumor Cells and CAFs for the Treatment of Breast Cancer	6
Investigating the Therapeutic Potential and Molecular Mechanisms ofDaphnetin: A Comprehensive Review	6
A Synergistic Combination of Oleanolic Acid and Apatinib to Enhance Antitumor Effect on Liver Cancer Cells and Protect against Hepatic Injury	6
Targeting Notch Pathway in Cancer Diagnostics and Therapeutics: An Emerging Approach	5
Morusin Suppresses Pancreatic Cancer Cell Proliferation and Migrationby Targeting SLC6A12 to Inhibit NF-κB and β-catenin SignalingPathways	5
LMNB1 and LMNB2 as Prognostic Risk Factors in Hepatocellular Carcinoma: Therapeutic Potential of GSK461364 via Downregulation of LMNB1 and LMNB2 Expression	5
Exploring the Molecular Mechanisms and Biological Effects of CELF2 in the Development of Gastric Cancer	5
Development of a Novel Lipid Metabolism-related Gene Prognostic Signature for Patients with Colorectal Cancer	5
Patents on PARP-1 Inhibitors for the Management of Cancer from 2017-2023	5
Exosome-Derived Cargos in Immune Microenvironment in Esophageal Carcinoma: A Mini-Review	5
KRAS Pathways: A Potential Gateway for Cancer Therapeutics and Diagnostics	5

Daidzein and Chicory Extract Arrest the Cell Cycle via Inhibition of Cyclin D/CDK4 and Cyclin A/CDK2 Gene Expression in Hepatocellular Carcinoma	5
Nano-carriers based Approaches Loaded with Herbal Bioactive Compounds for the Treatment of Cancer: Recent Updates and Future Prospects	5
LINC00936/microRNA-221-3p Regulates Tumor Progression in Ovarian Cancer by Interacting with LAMA3	5
Epigallocatechin Gallate Derivative Y6 Reverses Oxaliplatin Resistance inHepatocellular Carcinoma via Targeting the MiR-338-3p/HIF-1α/TWISTAxis to Inhibit EMT	4
Patent Selections	4
Identification of Breast Cancer Immune-related Prognostic Characteristics in Tumor Microenvironment	4
ZFP36L1 Promotes Gastric Cancer Progression via Regulating JNK and p38 MAPK Signaling Pathways	4
Structure-Based Virtual Screening of Novel FOXM1 Inhibitors as Potential Compounds for Glioblastoma Treatment	4
Targeting Ferroptosis as a New Approach for Radiation Protection and Mitigation	4
Altering Landscape of Cancer Vaccines: Unique Platforms, Research on Therapeutic Applications and Recent Patents	4
Ribosome-inactivating Protein MAP30 Isolated from Momordica Charantia L. Induces Apoptosis in Hepatocellular Carcinoma Cells	4
TGF-β Score based on Silico Analysis can Robustly Predict Prognosis and Immunological Characteristics in Lower-grade Glioma: The Evidence from Multicenter Studies	4
Strategies for Developing Cancer Theranostics Approaches	4
Green Synthesized Nanoparticles as a Plausible Therapeutic Strategy Against Hepatocellular Carcinoma: An Update on its Preclinical and Clinical Relevance	3
Differentiation of Acute Leukemia Cells Including Cells with MLL-AF4 Rearrangements Induced by Jiyuan Oridonin A	3
Recent Patents of Pharmaceutical Co-Crystals: Product Development on Anti-Cancer Drugs and Beyond	3
Ultrasound-Mediated Cancer Therapeutics Delivery using Micelles and Liposomes: A Review	3
Competitive Effect of Overexpressed C-terminal of Snail-1 (CSnail) in Control of the Growth and Metastasis of Melanoma Cells	3
Antibody-drug Conjugates for Breast Cancer Treatment	3
β-estradiol Induces Mitochondrial Apoptosis in Cervical Cancer through the Suppression of AKT/NF-κB Signaling Pathway	3
New 1H-pyrazolo[3,4-d]pyrimidin-1-yl)ethyl)-2-phenylisoquinoline-1(2H)-ones as Phosphoinositide 3-kinase Inhibitors for Treating Cancer and Other Diseases	3
A Single-arm, Open-label, Phase Ib Clinical Study Evaluating the Efficacy and Safety of Durvalumab in Combination with Albumin-bound Paclitaxel and Carboplatin as Neoadjuvant Therapy for Resectable St	3
Patent Selections	3
Eukaryotic Initiation Factor 3C Can Affect the Proliferation and Invasion of Ovarian Cancer by Regulating the p53 Signalling Pathway	3
Meet the Editorial Board Member	3
Patent Selections	3
The Impact of Polyphenolics in the Management of Breast Cancer: Mechanistic Aspects and Recent Patents	3
Meet the Associate Editorial Board Member	3
Adhesin Component Member STAG2 Enhances Cisplatin Tolerance inColorectal Cancer Cells through the Epithelial-mesenchymal TransitionPathway	3
Transdermal Drug Delivery: A Step towards Treatment of Cancer	2
Unveiling miR-1468-5p: A New Prognostic Biomarker and Therapeutic Target in Lung Adenocarcinoma	2
Dahuang Zhechong Pill Combined with TNS4 Silencing Inhibits theNF-κB/VEGF Pathway To Slow Down The Progression Of PancreaticCancer	2
Nanotechnology a Boon for Colorectal Cancer Treatment	2
TENT5A Increases Glioma Malignancy and Promotes its Progression	2
The Non-hodgkin Lymphoma Treatment and Side Effects: A Systematic Review and Meta-analysis	2
Inhibiting the Activity of ABCG2 by KU55933 in Colorectal Cancer	2
The Role of KCNMA1 Expression in Digestive Cancers: A Potential Prognostic Biomarker	2
1,3,4-Oxadiazoles as Anticancer Agents: A Review	2
Downregulation of miRNA-14669 Reverses Vincristine Resistance in Colorectal Cancer Cells through PI3K/AKT Signaling Pathway	2
Metal Nanoparticles as Emerging Drug Candidates in the Management of Cancers and Microbial Infectious Diseases	2
Nano-Based Drug Delivery of Anticancer Chemotherapeutic Drugs Targeting Breast Cancer	2
Phytochemicals and Nanoparticles in the Modulation of PI3K/Akt/mTOR Kinases and its Implications in the Development and Progression of Gastrointestinal Cancers: A Review of Preclinical and Clinical Ev	2
Updated Progress on Mass Spectrometry Imaging and its Application in Cancer Treatment and Drug Discovery	2
Development and Evaluation of a Novel Hyaluronic Acid and Chitosan-modified Phytosome for Co-delivery of Oxymatrine and Glycyrrhizin for Combination Therapy	2
Increased SLC7A3 Expression Inhibits Tumor Cell Proliferation and Predicts a Favorable Prognosis in Breast Cancer	2
Patent Selections	2
West African Medicinal Plant Substances and Molecules ActivitiesAgainst Viral Hepatitis B and Hepatocellular Carcinoma	2
Preclinical Effects of Melatonin on the Development of Ehrlich's Tumor: A Biochemical, Cognitive, and Molecular Approach	2
The Validity of Mobile Applications to Facilitate Patient Care Provided to Cancer Patients: Opportunities and Limitations	1
Differential Expression and Distribution of Slco4a1 and Slco1b2 in anInternal Environment Disorder-induced Hepatocellular Carcinoma MouseModel	1
Characterization of the Prognosis and Tumor Microenvironment of Cellular Senescence-related Genes through scRNA-seq and Bulk RNA-seq Analysis in GC	1
Acknowledgements to Contributor	1
Sema3A Affect Osteolytic Bone Metastasis of Non-small Cell Lung Cancer	1
Prediction of Cancer Treatment Using Advancements in Machine Learning	1
Neochamaejasmine A Promotes Apoptosis and Cell Cycle Arrest in B16F10 Melanoma Cells via JNK and p38 MAPK Signaling Pathway	1
The Patent Landscape of BRAF Target and KRAS Target	1
Selinexor as a Therapeutic Target: Advances in Non-small Cell and Small Cell Lung Cancer Treatment Strategies	1
Identification of Immune Infiltration-related Molecular Features inOvarian Cancer Patients and Experimental Validation of ImmuneResponse Molecular Mechanisms through Integrated WGCNA, MachineLearning,	1
Knockdown of RhoA Expression Reverts Enzalutamide Resistance via the p38 MAPK Pathway in Castration-resistant Prostate Cancer	1
CK2B is a Prognostic Biomarker and a Potential Drug Target for Hepatocellular Carcinoma	1
Eudragit, a Nifty Polymer for Anticancer Preparations: A Patent Review	1
Withdrawn: Fumarate-1 Mediates the Regulation of Mitochondrial Homeostasis by PGC-1α to Promote Cell Pyroptosis and Inhibit the Thyroid Cancer	1
Patent Selections	1
Acknowledgements to Reviewer	1
LncRNA FAM83H-AS1 Contributes to the Radio-resistance and Proliferation in Liver Cancer through Stability FAM83H Protein	1
A Descriptive Review of Cannabis sativa Patents for Cancer Treatment	1
From Multiple Myeloma to Acute Myeloid Leukemia: A Case Report of a 61-year-old Woman after 8 Years of Chemotherapy and Immunotherapy	1
Advances in Artemisinin-based Therapies: Innovations in Synthesis, Drug Delivery, and Expanding Therapeutic Applications	1
The Clinical Significance and Prognostic Value of ALDH1 Expression in Non-small Cell Lung Cancer: A Systematic Review and Meta-analysis	1
B-9-8, a Novel Harman Dimer, Reverses ABCG2-mediated Chemotherapeutic Drug Resistance	1
The Efficacy and Safety of Anlotinib Alone and in Combination with Other Drugs in Previously Treated Advanced Thymic Epithelia Tumors: A Retrospective Analysis	1
The Synergistic Anti-tumor Effects of Evodiamine based on Animal Model Experiments: A Systematic Review and Meta-analysis	1
Comprehensive Analysis and Experimental Validation of TLL2 as a Potential New Prognostic Biomarker Associated with Immune Infiltration in Lung Adenocarcinoma	1
The ER Stress-related Gene Prognostic Signature for PredictingChemosensitivity and Prognosis in AML	1
Development and Validation of a Hypoxia-related Prognostic Model for Ovarian Cancer	1
PDLIM1 Inhibits Chemoresistance by Blocking DNA Damage Repair in Gastric Cancer	1
PSMA PET/MR is a New Imaging Option for Identifying Glioma Recurrence and Predicting Prognosis	1
Gefitinib: An Updated Review of its Role in the Cancer Management, its Nanotechnological Interventions, Recent Patents and Clinical Trials	1
A Link Between Chemical Structure and Biological Activity in Triterpenoids	1
Roles of TEAD Transcription Factors and their Coactivators in the Progression and Metastasis of Cancers	1

Pseudo-ginsenoside Rh2 Induces Protective Autophagy in Hepatocellular Carcinoma HepG2 Cells	1
Diosgenin-loaded Silver Nanoparticles: Dual Protective Role and Enhanced Radiosensitivity against ENU-induced Leukemia and γ-irradiation-inducedLiver Toxicity	1
Recent Progress in Natural Anticancer Agents Discovery from Tea (Camellia sinensis): A Review	1
Fatty Acid Metabolism Signature Contributes to the Molecular Diagnosis of a Malignant Gastric Cancer Subtype with Poor Prognosis and Lower Mutation Burden	1