OOIR: Observatory of International Research

Papers

(The median citation count of Immune Network is 4. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2022-08-01 to 2026-08-01.)

Article	Citations
Phosphatase Ssu72 Is Essential for Homeostatic Balance Between CD4⁺ T Cell Lineages	108
Sphingosylphosphorylcholine Promotes Th9 Cell Differentiation Through Regulation of Smad3, STAT5, and β-Catenin Pathways	63
Advances in IL-2 Family Cytokine-Based Cancer Therapies: Overcoming Challenges Through Molecular Engineering and Delivery Strategies	56
Extracellular Mechanisms of Neutrophils in Immune Cell Crosstalk	54
Beyond Tumor Borders: Intratumoral Microbiome Effects on Tumor Behavior and Therapeutic Responses	44
Distinct T Cell Dysregulation Reflects Disease Severity and Progression in Infantile Epileptic Spasms Syndrome and Lennox-Gastaut Syndrome	43
IL-1 Receptor Dynamics in Immune Cells: Orchestrating Immune Precision and Balance	42
Harnessing the Gut Microbiota to Improve Cancer Immunotherapy: Focus on Lung Cancer	41
Current Developments in NK Cell Engagers for Cancer Immunotherapy: Focus on CD16A and NKp46	41
The Role of CD4 T Cell Help in CD8 T Cell Differentiation and Function During Chronic Infection and Cancer	34
Intestinal Dysbiosis Caused by Epithelial Fabp6 Gene Disruption Exacerbates Gut Inflammatory Disease	32
Immunosenescence and Cancer: Cellular Aging Programs That Reshape Antitumor Immunity	31
Strong Immune Privileges of MSC and Other Nes-GFP⁺ Progenitors in Bone Marrow of Transgenic Mice	28
Efficient In Vitro Plasma Cell Differentiation by B Cell Receptor Activation and Cytokine Stimulation	28
Glucocorticoids Impair the 7α-Hydroxycholesterol-Enhanced Innate Immune Response	28
Optimising IL-2 for Cancer Immunotherapy	28
Intranasal Delivery of an RSV A2-Derived Pre-F VLP Vaccine Induces Robust Mucosal and Systemic Immunity Against RSV B Strain Without Enhanced Disease	27
Altered Frequency, Activation, and Clinical Relevance of Circulating Innate and Innate-Like Lymphocytes in Patients With Alcoholic Liver Cirrhosis	27
STING-STAT6 Signaling Pathway Promotes IL-4⁺ and IFN-α⁺ Fibrotic T Cell Activation and Exacerbates Scleroderma in SKG Mice	27
COVID-19 Therapeutics: An Update on Effective Treatments Against Infection With SARS-CoV-2 Variants	27
Increased Inflammatory Responses in Patients With Active Disseminated Non-Tuberculous Mycobacterial Infection and High Anti-Interferon-Gamma Autoantibodies	24
Tissue-Specific Metabolic Reprogramming in Innate Lymphoid Cells and Its Impact on Disease	23
Oxidized LDL Accelerates Cartilage Destruction and Inflammatory Chondrocyte Death in Osteoarthritis by Disrupting the TFEB-Regulated Autophagy-Lysosome Pathway	23
Transcriptional and Epigenetic Regulation of Context-Dependent Plasticity in T-Helper Lineages	23
From Ex Vivo to In Vivo : Advances in Lentiviral Vector Engineering for CAR-T Therapy	23

Cigarette Smoke Extract-Treated Mouse Airway Epithelial Cells-Derived Exosomal LncRNA MEG3 Promotes M1 Macrophage Polarization and Pyroptosis in Chronic Obstructive Pulmonary Disease by Upregulating T	22
Recombinant Human Bone Morphogenetic Protein-2 Priming of Mesenchymal Stem Cells Ameliorate Acute Lung Injury by Inducing Regulatory T Cells	22
Neutrophil Migration Is Mediated by VLA-6 in the Inflamed Adipose Tissue	21
Exploring the Potential of Glycolytic Modulation in Myeloid-Derived Suppressor Cells for Immunotherapy and Disease Management	20
In Search of Adaptive-Like Features of NK Cells Co-Expressing NKG2C and NKG2A	20
Vaccine Strategy That Enhances the Protective Efficacy of Systemic Immunization by Establishing Lung-Resident Memory CD8 T Cells Against Influenza Infection	20
Unlocking IL-33: New Insights into Tumor Immunity	19
Shaping Heterogeneity of Naive CD8⁺ T Cell Pools	19
SiglecF Expressing Neutrophils Exacerbate Th17-Mediated Autoimmune Neuroinflammation	19
Regulatory T Cell Metabolism: A Promising Therapeutic Target for Cancer Treatment?	18
Enigmatic Roles of Complement Anaphylatoxin Signaling in Health and Disease	15
IL7-TBRII, a Dual Cytokine Modulator Targeting IL-7 and TGF-β Pathways, Inhibits Tumor Progression and Metastasis	15
Beyond Perineural Drainage: Revisiting the Olfactory Nerve as an Active Immunological Interface During Neuroinflammation	15
Soluble CCR2-Expressing Mesenchymal Stem Cells Inhibit Osteoarthritis Development and Progression	15
Distinct Transcriptional and Functional Differences of Lung Resident and Monocyte-Derived Alveolar Macrophages During the Recovery Period of Acute Lung Injury	14
Virus-like Particle Vaccines Containing RSV Fusion Protein Cleavage Mutations Are Immunogenic and Protective in Cotton Rats With a Prime Dose	14
NLRP3 Exacerbate NETosis-Associated Neuroinflammation in an LPS-Induced Inflamed Brain	14
Mitochondria Activity and CXCR4 Collaboratively Promote the Differentiation of CD11c⁺ B Cells Induced by TLR9 in Lupus	13
Decay-Accelerating Factor Differentially Associates With Complement-Mediated Damage in Synovium After Meniscus Tear as Compared to Anterior Cruciate Ligament Injury	12
Comparing the Benefits and Drawbacks of Stem Cell Therapy Based on the Cell Origin or Manipulation Process: Addressing Immunogenicity	12
NADPH Oxidase 4-mediated Alveolar Macrophage Recruitment to Lung Attenuates Neutrophilic Inflammation in Staphylococcus aureus Infection	11
Monovalent Anti-CD3 Antibodies Effectively Eliminate the TCR-Positive Fraction of TCR-Deleted Allogeneic CAR-T Cells to Prevent GVHD	11
Mitochondrial Regulator CRIF1 Plays a Critical Role in the Development and Homeostasis of Alveolar Macrophages via Maintaining Metabolic Fitness	11
Aging Mediates Inflammatory Transformation of Kidney-Resident Macrophages via Thrombospondin-1 Signaling	10
Dynamic Interplay Between Tumor Cells and the Immune System	10
Programmable Bacterial Contractile Injection Systems for Ag Delivery and CD8 ⁺ T Cell Activation	10
Regulatory T Cell Heterogeneity in the Steady State and Tumor	9
A Moonlighting Protein Secreted by a Nasal Microbiome Fortifies the Innate Host Defense Against Bacterial and Viral Infections	9
The Multifaceted Roles of NK Cells in the Context of Murine Cytomegalovirus and Lymphocytic Choriomeningitis Virus Infections	9
Low-Dose Radiotherapy Attenuates Experimental Autoimmune Arthritis by Inducing Apoptosis of Lymphocytes and Fibroblast-Like Synoviocytes	9
The Impact of Pulmonary Disorders on Neurological Health (Lung-Brain Axis)	8
The Role of Inflammasome-Associated Innate Immune Receptors in Cancer	8
Tissue-Resident ILC2s Across Organs: Heterogeneity, Niche Crosstalk, and Shared Regulatory Circuits	8
Adoptive Cellular Therapies in Pediatric Leukemia Patients After Allogeneic-Hematopoietic Stem Cell Transplants	8
Tumor Cells as Architects of Immune Refractoriness: Dismantling Intrinsic Programs of Tumor Cells for Clinical Translation	8
Regulation of Ferroptosis in Cancer and Immune Cells	8
Recombinant Human IL-32θ Induces Polarization Into M1-like Macrophage in Human Monocytic Cells	7
Complement Anaphylatoxin C5a-Induced Mouse Lymphatic Functions Modulate Interactions Between Endothelial Cells and T Lymphocytes	7
Diverse Functions of Macrophages in Obesity and Metabolic Dysfunction-Associated Steatotic Liver Disease: Bridging Inflammation and Metabolism	7
Bifidobacterium longum RAPO Attenuates Dermal and Pulmonary Fibrosis in a Mouse Model of Systemic Sclerosis through Macrophage Modulation and Growth of Short-Chain Fatty Acid Producers	7
Cytokines, Vascular Endothelial Growth Factors, and PlGF in Autoimmunity: Insights From Rheumatoid Arthritis to Multiple Sclerosis	7
Metabolic Challenges in Anticancer CD8 T Cell Functions	7
Comprehensive Transcriptomic Analysis for Thymic Epithelial Cells of Aged Mice and Humans	7
T Cell Microvilli: Finger-Shaped External Structures Linked to the Fate of T Cells	6
Synergistic Induction of Neutrophilic Inflammatory Programs by Staphylococcus aureus and Cigarette Smoke in Airway Epithelial Cells	6
Cytokines and Immune Disorders: Illuminating Cytokines as Hubs Within the Immune Network	6
Interleukin-18 Binding Protein (IL-18BP): A Long Journey From Discovery to Clinical Application	6
COVID-19 Vaccination Alters NK Cell Dynamics and Transiently Reduces HBsAg Titers Among Patients With Chronic Hepatitis B	6
Modulation of Immune Responses by Metabolic Reprogramming: The Key Role of Immunometabolism	6
Roles of Virtual Memory T Cells in Diseases	6

Bone Marrow Progenitors and IL-2 Signaling Contribute to the Strain Differences of Kidney Innate Lymphoid Cells	6
Cytokine Storm Related to CD4⁺ T Cells in Influenza Virus-Associated Acute Necrotizing Encephalopathy	6
T Cell Resistance: On the Mechanisms of T Cell Non-activation	5
Influenza Virus-Derived CD8 T Cell Epitopes: Implications for the Development of Universal Influenza Vaccines	5
IL-17 and IL-21: Their Immunobiology and Therapeutic Potentials	5
Immune Cells Are Differentially Affected by SARS-CoV-2 Viral Loads in K18-hACE2 Mice	4
Cytokine Engineering in CAR-T Cell Therapy: Next-Generation Strategies	4
Ubiquitin-like Proteins in Autoimmune Diseases: Current Evidence and Therapeutic Opportunities	4
Decoding Immune Regulation: From Genetic Variation to Mechanism Through Single-Cell Genomics	4
Exosomes in Action: Unraveling Their Role in Autoimmune Diseases and Exploring Potential Therapeutic Applications	4
Role of the Aryl Hydrocarbon Receptor in the Self-Renewal, Differentiation, and Immunomodulation of Adult Stem Cells	4
Synovial Fluid as a Crucial Component of the Joint Microenvironment in Rheumatoid Arthritis	4