OOIR: Observatory of International Research

Papers

(The median citation count of Hereditas is 1. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-04-01 to 2025-04-01.)

Article	Citations
A pathogenic NR2F1 gene variant disrupts transcriptional activity and causes severe neurodevelopmental delay in Bosch-Boonstra-Schaaf syndrome	37
Identification of four novel hub genes as monitoring biomarkers for colorectal cancer	34
METTL3-dependent DLG2 inhibits the malignant progression of cervical cancer by inactivating the Hippo/YAP signaling	24
Identification of prognostic biomarker of non-small cell lung cancer based on mitochondrial permeability transition-driven necrosis-related genes and determination of anti-tumor effect of ARL14	20
Exploring the bidirectional causality between neuroticism and frailty: a Mendelian randomization analysis	20
Establishment and validation of a logistic regression model for prediction of septic shock severity in children	19
Exploring MAP3K genes in gastric cancer: biomarkers, tumor microenvironment dynamics, and chemotherapy resistance	19
m6A-related lncRNA-based immune infiltration characteristic analysis and prognostic model for colonic adenocarcinoma	18
HLA-A*03, the hemochromatosis ancestral haplotype, and phenotypes of referred hemochromatosis probands with HFE p.C282Y homozygosity	18
Extracellular vesicle-derived TP53BP1, CD34, and PBX1 from human peripheral blood serve as potential biomarkers for the assessment and prediction of vascular aging	16
Bioinformatic analysis identifies potential biomarkers and therapeutic targets of septic-shock-associated acute kidney injury	15
Variations in the TAS2R38 gene among college students in Hubei	13
Investigating the shared genetic structure between rheumatoid arthritis and stroke	13
Screening of ulcerative colitis biomarkers and potential pathways based on weighted gene co-expression network, machine learning and ceRNA hypothesis	12
A novel risk model consisting of nine platelet-related gene signatures for predicting prognosis, immune features and drug sensitivity in glioma	12
Glutamine metabolism-related genes predict the prognostic risk of acute myeloid leukemia and stratify patients by subtype analysis	11
Circular RNAs: novel noncoding players in male infertility	11
ADME gene-driven prognostic model for bladder cancer: a breakthrough in predicting survival and personalized treatment	11
IFNAR1 gene mutation may contribute to developmental stuttering in the Chinese population	10
Forkhead box P3 gene polymorphisms predispose to type 2 diabetes and diabetic nephropathy in the Han Chinese populations: a genetic-association and gender-based evaluation study	9
Mendel’s controlled pollination experiments in Mirabilis jalapa confirmed his discovery of the gamete theory of inheritance in Pisum	9
SOLAMEN syndrome with cardiovascular damage	9
Association of novel MUC16, MAP3K15 and ABCA1 mutation with giant congenital melanocytic nevus	9
Mendel’s terminology and notation reveal his understanding of genetics	9
A potential immunotherapeutic and prognostic biomarker for multiple tumors including glioma: SHOX2	9

A novel chromatin regulator-related immune checkpoint related gene prognostic signature and potential candidate drugs for endometrial cancer patients	9
Insulin-like growth factor binding protein 2: a core biomarker of left ventricular dysfunction in dilated cardiomyopathy	8
Identifying and predicting the pathogenic effects of a novel variant inducing severe early onset MMA: a bioinformatics approach	8
Genetic insights into therapeutic targets for gout: evidence from a multi-omics mendelian randomization study	8
Erianin inhibits the progression of DDP-resistant lung adenocarcinoma by regulating the Wnt/β-catenin pathway and activating the caspase-3 for apoptosis in vitro and in vivo	8
A novel mutation in the FGG gene causes hypofibrinogenemia in a Chinese family	8
LPAR2 correlated with different prognosis and immune cell infiltration in head and neck squamous cell carcinoma and kidney renal clear cell carcinoma	7
Immunomodulatory insights of monoterpene glycosides in endometriosis: immune infiltration and target pathways analysis	7
A novel approach for breast cancer treatment: the multifaceted antitumor effects of rMeV-Hu191	7
EZH2 regulates pancreatic cancer cells through E2F1, GLI1, CDK3, and Mcm4	6
Identification of potential biomarkers for pathogenesis of Alzheimer’s disease	6
Upregulation of CENPM is associated with poor clinical outcome and suppression of immune profile in clear cell renal cell carcinoma	6
Correction to: Genetic polymorphism of IDOL gene was associated with the susceptibility of coronary artery disease in Han population in Xinjiang, China	6
Serum vitamin C levels and risk of osteoporosis: results from a cross-sectional study and Mendelian randomization analysis	5
Novel Antennapedia and Ultrabithorax trimeric complexes with TBP and Exd regulate transcription	5
The unidirectional phylogeny of Homo sapiens anchors the origin of modern humans in Eurasia	5
HOXD9/APOC1 axis promotes macrophage M1 polarization to exacerbate diabetic kidney disease progression through activating NF-κB signaling pathway	5
Comprehensive analysis of a necroptosis-associated diagnostic signature for myelodysplastic syndromes based on single-cell RNA-seq and bulk RNA-seq	5
Investigating the effects of global gene knockout of MrgF on motor performance and pain sensitivity in mice	5
Comprehensive evaluations of individual discrimination, kinship analysis, genetic relationship exploration and biogeographic origin prediction in Chinese Dongxiang group by a 60-plex DIP panel	5
Identification of biomarkers and mechanism exploration of ferroptosis related genes regulated by m6A in type 2 diabetes mellitus	4
Identification and validation of hub genes of synovial tissue for patients with osteoarthritis and rheumatoid arthritis	4
Cell-free DNA from plasma as a promising alternative for detection of gene mutations in patients with Maffucci syndrome	4
Identification of subtypes and biomarkers associated with disulfidptosis-related ferroptosis in ulcerative colitis	4
NPM3 as a novel oncogenic factor and poor prognostic marker contributes to cell proliferation and migration in lung adenocarcinoma	4
Mediating Mendelian randomization in the proteome identified potential drug targets for obesity-related allergic asthma	4
Disulfidptosis classification of pancreatic carcinoma reveals correlation with clinical prognosis and immune profile	4
An 8-gene predicting survival model of hepatocellular carcinoma (HCC) related to pyroptosis and cuproptosis	4
SNP-based breeding for broiler resistance to ascites and evaluation of correlated production traits	4
Identification of endoplasmic reticulum stress and mitochondrial dysfunction related biomarkers in osteoporosis	4
A novel compound heterozygous mutation in the DYNC2H1 gene in a Chinese family with Jeune syndrome	4
Functional analysis of enhancer elements regulating the expression of the Drosophila homeodomain transcription factor DRx by gene targeting	4
Whole-exome sequencing detected a novel AIFM1 variant in a Han-Chinese family with Cowchock syndrome	4
Identification of key apoptosis-related genes and immune infiltration in the pathogenesis of psoriasis	4
N6-methyladenosine-related lncRNAs is a potential marker for predicting prognosis and immunotherapy in ovarian cancer	4
Lipidomics-based investigation of its impact on the pathogenesis of coronary atherosclerosis: a Mendelian randomization study	4
Stable populations and Hardy-Weinberg equilibrium	3
Regulation of DNA methylation on key parasitism genes of Cysticercus cellulosae revealed by integrative epigenomic-transcriptomic analyses	3
Identification of necroptosis genes and characterization of immune infiltration in non-alcoholic steatohepatitis	3
Gene expression trend changes in breast cancer populations over two decades: insights from The Cancer Genome Atlas database	3
Inhibition of USP14 suppresses ferroptosis and inflammation in LPS-induced goat mammary epithelial cells through ubiquitylating the IL-6 protein	3
Can Omega-3 prevent the accidence of stroke: a mendelian randomization study	3
Comprehensive analysis to identify pseudogenes/lncRNAs-hsa-miR-200b-3p-COL5A2 network as a prognostic biomarker in gastric cancer	3
DNA hypomethylation of INHBA promotes tumor progression and predicts prognosis and immune status of gastric cancer	3
LncRNA WAC-AS1 expression in human tumors correlates with immune infiltration and affects prognosis	3
Enhancer analysis of the Drosophila zinc finger transcription factor Earmuff by gene targeting	3
A cuproptosis-related lncRNA signature for predicting prognosis and immunotherapy response of lung adenocarcinoma	3
Huanglian-Hongqu herb pair improves nonalcoholic fatty liver disease via NF-κB/NLRP3 pathway in mice: network pharmacology, molecular docking and experimental validation	3
Identification of biomarkers, immune infiltration landscape, and treatment targets of ischemia–reperfusion acute kidney injury at an early stage by bioinformatics methods	3
Identification of novel mutations among Iranian NPC1 patients: a bioinformatics approach to predict pathogenic mutations	3

Integrative single-cell analysis: dissecting CD8 + memory cell roles in LUAD and COVID-19 via eQTLs and Mendelian Randomization	3
Activation of TRAF1 induced by USP7/SP1 exacerbates the severity of infantile pneumonia	2
Acetylation proteomics and metabolomics analyses reveal the involvement of starch synthase undergoing acetylation modification during UV-B stress resistance in Rhododendron Chrysanthum Pall	2
An Axin2 mutation and perinatal risk factors contribute to sagittal craniosynostosis: evidence from a Chinese female monochorionic diamniotic twin family	2
Favorable function of Ectonucleoside triphosphate diphosphohydrolase 1 high expression in thyroid carcinoma	2
METTL14 contributes to the progression of nasopharyngeal carcinoma through regulating the stability of AOC1 mRNA	2
Bioinformatic analysis and experimental validation of cuproptosis-related LncRNA as a novel biomarker for prognosis and immunotherapy of oral squamous cell carcinoma	2
RTP4 is a novel prognosis-related hub gene in cutaneous melanoma	2
Identification and functional characterization of key biomarkers in diffuse large B-cell lymphoma: emphasis on STYX as a prognostic marker and therapeutic target	2
Enhancer-driven transcription of MCM8 by E2F4 promotes ATR pathway activation and glioma stem cell characteristics	2
Transcriptome sequencing reveals core regulation modules and gene signatures of Zusanli acupoints in response to different moxibustion warm stimulation in adjuvant arthritis rat	2
Integrative analyses of genes related to liver ischemia reperfusion injury	2
An artificial neural network model based on autophagy-related genes in childhood systemic lupus erythematosus	2
Prognostic biomarkers and therapeutic targets in oral squamous cell carcinoma: a study based on cross-database analysis	2
A pan-cancer analysis of Dyskeratosis congenita 1 (DKC1) as a prognostic biomarker	2
SREBF1, a target gene of multiple sclerosis and coronary heart disease: based on mendelian randomization study	2
RNA sequencing analyses in infants patients with coarctation of the aorta	2
Identification of crucial genes involved in pathogenesis of regional weakening of the aortic wall	2
RNA-Seq based transcriptome analysis in oral lichen planus	2
Causal association between blood metabolites and head and neck cancer: butyrylcarnitine identified as an associated trait for cancer risk and progression	2
Elevated HMGB1 promotes the malignant progression and contributes to cisplatin resistance of non-small cell lung cancer	2
CCR5 as a prognostic biomarker correlated with immune infiltrates in head and neck squamous cell carcinoma by bioinformatic study	2
Mutation update of SERPING1 related to hereditary angioedema in the Chinese population	1
Screening and analysis of programmed cell death related genes and targeted drugs in sepsis	1
CDCA genes as prognostic and therapeutic targets in Colon adenocarcinoma	1
Susceptibility genes of hyperuricemia and gout	1
MiR−33 as a novel diagnostic biomarker for distinguishing cholesterol from adenomatous polyps: a case-control study	1
Mutations in the acetolactate synthase (ALS) enzyme affect shattercane (Sorghum bicolor) response to ALS-inhibiting herbicides	1
Identification of a five-miRNA signature as a novel potential prognostic biomarker in patients with nasopharyngeal carcinoma	1
Identification of tubulointerstitial genes and ceRNA networks involved in diabetic nephropathy via integrated bioinformatics approaches	1
The causal effects between low back pain and cerebrospinal fluid metabolites: a two-sample Mendelian randomization study	1
Identification and development of the novel 7-genes diagnostic signature by integrating multi cohorts based on osteoarthritis	1
Network analysis of potential risk genes for psoriasis	1
SLC3A2 inhibits ferroptosis in laryngeal carcinoma via mTOR pathway	1
ARG1 as a promising biomarker for sepsis diagnosis and prognosis: evidence from WGCNA and PPI network	1
Insights into AIM-InDel diversities in Yunnan Miao and Hani ethnic groups of China for forensic and population genetic purposes	1
Exploring the association between rheumatoid arthritis and non-small cell lung cancer risk: a transcriptomic and drug target-based analysis	1
Circular RNA circHMCU promotes breast tumorigenesis through miR-4458/PGK1 regulatory cascade	1
Knockdown of IGF2BP2 overcomes cisplatin-resistance in lung cancer through downregulating Spon2 gene	1
Deciphering the potential ability of RG108 in cisplatin-induced HEI-OC1 ototoxicity: a research based on RNA-seq and molecular biology experiment	1
Understanding the contemporary high obesity rate from an evolutionary genetic perspective	1
Mir-615-5p inhibits cervical cancer progression by targeting TMIGD2	1
SKA3 is a prognostic biomarker and associated with immune infiltration in bladder cancer	1
Mechanistic insights into CDCA gene family-mediated glioblastoma progression: implications for diagnosis, prognosis, and therapeutic targeting	1
CircCENPM serves as a CeRNA to aggravate nasopharyngeal carcinoma metastasis and stemness via enhancing BMI1	1
Mir-150-5p distinguishes acute pulmonary embolism, predicts the occurrence of pulmonary arterial hypertension, and regulates ox-LDL-induced endothelial cell injury	1
RNA binding protein ILF3 increases CEP55 mRNA stability to enhance malignant potential of breast cancer cells and suppress ferroptosis	1
Trimeric complexes of Antp-TBP with TFIIEβ or Exd modulate transcriptional activity	1
Identification of a chromatin regulator signature and potential candidate drugs for bladder cancer	1