OOIR: Observatory of International Research

Papers

(The H4-Index of Frontiers in Pharmacology is 81. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-11-01 to 2025-11-01.)

Article	Citations
Editorial: Therapeutic drug monitoring (TDM): a useful tool for pediatric pharmacology applied to routine clinical practice, Volume II	706
Efficacy of interventions with live combined Bacillus subtilis and Enterococcus faecium enteric-coated capsules in metabolic associated fatty liver disease patients: a meta-analysis of randomized cont	376
Quantum chemical calculations of nitrosamine activation and deactivation pathways for carcinogenicity risk assessment	365
Association between hyperuricemia and all-cause mortality in people taken Statins: a retrospective cohort study	343
pH-induced conformational changes in the selectivity filter of a potassium channel lead to alterations in its selectivity and permeation properties	331
D-cycloserine effects on COPD and depression in a murine experimental model	312
GraphTransNet: predicting epilepsy-related genes using a graph-augmented protein language model	281
Licorice attenuates cisplatin-induced hepatotoxicity by alleviating endoplasmic reticulum stress and apoptosis	238
Gegen Qinlian decoction prevents post-ERCP pancreatitis by regulating NLRP3 inflammasome-mediated pyroptosis	213
Hydroxytyrosol Inhibits MDSCs and Promotes M1 Macrophages in Mice With Orthotopic Pancreatic Tumor	212
Traditional Chinese Medicine in Treating Primary Podocytosis: From Fundamental Science to Clinical Research	202
Unraveling the pathogenic mechanism of a novel filamin a frameshift variant in periventricular nodular heterotopia	194
Therapeutic drug monitoring practices of anti-infectives: An Asia-wide cross-sectional survey	186
Quantifying the integrated physiological effects of endothelin-1 on cardiovascular and renal function in healthy subjects: a mathematical modeling analysis	178
Editorial: Chronic pain: what is the mechanism?	175
Long-term clinical course and outcomes of patients with microscopic polyangiitis-associated interstitial lung disease	174
Indirect effect of alpha-1-antitrypsin on endotoxin-induced IL-1β secretion from human PBMCs	174
Corrigendum: Xenon attenuated neonatal lipopolysaccharide exposure induced neuronal necroptosis and subsequently improved cognition in juvenile rats	166
Editorial: Oral mucosa and disorders: from drug discovery to development and translation	156
Time trends and regional variations in prices of anticancer medicines in China	153
Pre- and post-chemotherapy spermatogenesis in male patients with malignant bone and soft tissue tumors	148
The categorizations of vasculogenic mimicry in clear cell renal cell carcinoma unveil inherent connections with clinical and immune features	148
Advances in the study of Ophiopogon japonicus polysaccharides: structural characterization, bioactivity and gut microbiota modulation regulation	138
Editorial: Impact of anesthetics on cancer behavior and outcome	137
Cyclohexene oxide CA, a derivative of zeylenone, exhibits anti-cancer activity in glioblastoma by inducing G0/G1 phase arrest through interference with EZH2	137

Unlocking cellular traffic jams: olive oil-mediated rescue of CNG mutant channels	134
Erratum: Isoflurane-lipid emulsion injection as an anticonvulsant and neuroprotectant treatment for nerve agent exposure	133
Sputum microbe community alterations induced by long-term inhaled corticosteroid use are associated with airway function in chronic obstructive pulmonary disease patients based on metagenomic next-gen	130
Editorial: Interplays and Functions of Gaseous Mediators: From Underlying Mechanisms to Therapeutic Approaches in Cardiovascular Diseases	130
Ginseng and Polygonum multiflorum formula protects brain function in Alzheimer’s disease	127
Impact of domiciliary administration of NSAIDs on COVID-19 hospital outcomes: an unCoVer analysis	126
RRx-001 Exerts Neuroprotection Against LPS-Induced Microglia Activation and Neuroinflammation Through Disturbing the TLR4 Pathway	125
AduCPI2 alleviates MSU-induced acute gouty arthritis in mice by inhibiting cathepsin S and the C5a-C5aR1 axis	124
Editorial: Methods in predictive toxicology 2023	123
Efficacy and safety of Abelmoschus moschatus capsules combined with tripterygium glycoside tablets on diabetic nephropathy: A systematic review and meta-analysis	122
Integrating single-cell RNA-seq, bulk RNA-seq and network pharmacology reveals protective effect of salidroside in peritoneal dialysis-associated peritoneal fibrosis	119
Corrigendum: Shu-Xie decoction alleviates oxidative stress and colon injury in acute sleep-deprived mice by suppressing p62/KEAP1/NRF2/HO1/NQO1 signaling	119
Plasma calcitonin gene-related peptide and nitric oxide predict therapeutic response to amlodipine in pediatric primary hypertension	118
Associations between ionomic profile and metabolic abnormalities in a murine model of sodium sulfide induced alopecia areata	118
Pre-clinical toxicity assessment of Artemisia absinthium extract-loaded polymeric nanoparticles associated with their oral administration	118
Strategies for salvage therapy post CAR-T therapy failure in refractory/relapsed multiple myeloma patients	115
Chinese herbal compound for multidrug-resistant or extensively drug-resistant bacterial pneumonia: a meta-analysis and trial sequential analysis with association rule mining to identify core herb comb	114
Safety evaluation of medroxyprogesterone acetate: a pharmacovigilance analysis using FDA adverse event reporting system data	113
Nodosin Exerts an Anti-Colorectal Cancer Effect by Inhibiting Proliferation and Triggering Complex Cell Death in Vitro and in Vivo	112
Long-term administration of bumetanide improve functional recovery after spinal cord injury in rats	112
Differences in right ventricular function and response to targeted therapy between patients with IPAH and PAH-CHD	111
Role of ferroptosis in atrial fibrillation: a review	110
Editorial: Utilizing omics strategies to discover new drug targets for cancers	108
Editorial: Autoimmune and Inflammatory Rheumatic Diseases: Identifying Biomarkers of Response to Therapy With Biologics	107
Effect of Fu Zheng Jie Du Formula on outcomes in patients with severe pneumonia receiving prone ventilation: a retrospective cohort study	107
The efficacy of aminosalicylates in acute radiation enteritis: a systematic review and meta-analysis	107
Potential efficacy and mechanisms of icariin for the animal model of osteonecrosis of the femoral head	106
The functional significance of vascular DNA hypermethylation in atherosclerosis: a historical perspective	106
Exploration of the Mechanism of Salvianolic Acid for Injection Against Ischemic Stroke: A Research Based on Computational Prediction and Experimental Validation	104
CDFA: Calibrated deep feature aggregation for screening synergistic drug combinations	99
Chemical synthesis of a reported p47phox/p22phox inhibitor and characterization of its instability and irreproducible activity	95
Does preterm birth increase the initiation of antidepressant use during the postpartum? A population-based investigation	95
Hepatoprotective Efficacy and Interventional Mechanism of Qijia Rougan Decoction in Liver Fibrosis	94
Potential mechanisms of Lian-Zhi-Fan solution for TNBS-induced ulcerative colitis in rats via a metabolomics approach	94
Case Report: Rhabdomyolysis secondary to vildagliptin overdose in a suicidal attempt: A case report and brief literature review	94
Interleukin 22 and its association with neurodegenerative disease activity	92
Development of a vaccine against the synthetic opioid U-47700	91
Naoxintong capsule for treating cardiovascular and cerebrovascular diseases: from bench to bedside	91
Interaction and potential mechanisms between atorvastatin and voriconazole, agents used to treat dyslipidemia and fungal infections	90
Anticancer effects of OSW-1 on glioma cells via regulation of the PI3K/AKT signal pathway: A network pharmacology approach and experimental validation in vitro and in vivo	90
Association between antihypertensive drugs and oral cancer: a drug target Mendelian randomization study	88
Investigation of anti-depression effects and potential mechanisms of the ethyl acetate extract of Cynomorium songaricum Rupr. through the integration of in vivo experiments, LC-MS/MS chemical analysis	87
The therapeutic potential of natural metabolites in targeting endocrine-independent HER-2-negative breast cancer	87
Research hotspots and trend analysis of cell transplantation in traumatic spinal cord injury: a bibliometric and visualized analysis	86
IgG-like Bispecific Antibody CD3×EpCAM Generated by Split Intein Against Colorectal Cancer	85
Drug-related problems among transfusion-dependent thalassemia patients: A real-world evidence study	84
Identification of highly effective inhibitors against SARS-CoV-2 main protease: From virtual screening to in vitro study	84
Wenshen-Jianpi prescription, a Chinese herbal medicine, improves visceral hypersensitivity in a rat model of IBS-D by regulating the MEK/ERK signal pathway	84
Editorial: Women in nanomedicine	84
Survival analysis of a 16-year cohort of follicular lymphoma patients receiving systemic treatment in Brazil	84

Patient-Patient Similarity-Based Screening of a Clinical Data Warehouse to Support Ciliopathy Diagnosis	83
Dioscin Reduces Vascular Damage in the Retina of db/db Mice by Inhibiting the VEGFA Signaling Pathway	82
The Protective Effects of Lipid-Lowering Agents on Cardiovascular Disease and Mortality in Maintenance Dialysis Patients: Propensity Score Analysis of a Population-Based Cohort Study	82
Potential Treat-to-Target Approach for Methamphetamine Use Disorder: A Pilot Study of Adenosine 2A Receptor Antagonist With Positron Emission Tomography	82
Healthcare professional perspectives on medication challenges in the post-stroke patient	82
Olmesartan Attenuates Single-Lung Ventilation Induced Lung Injury via Regulating Pulmonary Microbiota	81
Corrigendum: Editorial: The mechanisms of action of anti-SARS-CoV-2 drugs	81
The essential role of YAP in ERα36-mediated proliferation and the epithelial-mesenchymal transition in MCF-7 breast cancer cells	81