OOIR: Observatory of International Research

Papers

(The H4-Index of Frontiers in Pharmacology is 82. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2022-01-01 to 2026-01-01.)

Article	Citations
Editorial: Therapeutic drug monitoring (TDM): a useful tool for pediatric pharmacology applied to routine clinical practice, Volume II	768
Efficacy of interventions with live combined Bacillus subtilis and Enterococcus faecium enteric-coated capsules in metabolic associated fatty liver disease patients: a meta-analysis of randomized cont	415
Quantum chemical calculations of nitrosamine activation and deactivation pathways for carcinogenicity risk assessment	367
Association between hyperuricemia and all-cause mortality in people taken Statins: a retrospective cohort study	361
pH-induced conformational changes in the selectivity filter of a potassium channel lead to alterations in its selectivity and permeation properties	334
D-cycloserine effects on COPD and depression in a murine experimental model	313
GraphTransNet: predicting epilepsy-related genes using a graph-augmented protein language model	308
Traditional Chinese Medicine in Treating Primary Podocytosis: From Fundamental Science to Clinical Research	272
Unraveling the pathogenic mechanism of a novel filamin a frameshift variant in periventricular nodular heterotopia	236
Quantifying the integrated physiological effects of endothelin-1 on cardiovascular and renal function in healthy subjects: a mathematical modeling analysis	235
Editorial: Chronic pain: what is the mechanism?	226
Long-term clinical course and outcomes of patients with microscopic polyangiitis-associated interstitial lung disease	202
Indirect effect of alpha-1-antitrypsin on endotoxin-induced IL-1β secretion from human PBMCs	200
Corrigendum: Xenon attenuated neonatal lipopolysaccharide exposure induced neuronal necroptosis and subsequently improved cognition in juvenile rats	196
Editorial: Oral mucosa and disorders: from drug discovery to development and translation	194
Time trends and regional variations in prices of anticancer medicines in China	188
Pre- and post-chemotherapy spermatogenesis in male patients with malignant bone and soft tissue tumors	188
The categorizations of vasculogenic mimicry in clear cell renal cell carcinoma unveil inherent connections with clinical and immune features	182
Editorial: Impact of anesthetics on cancer behavior and outcome	161
Cyclohexene oxide CA, a derivative of zeylenone, exhibits anti-cancer activity in glioblastoma by inducing G0/G1 phase arrest through interference with EZH2	159
Unlocking cellular traffic jams: olive oil-mediated rescue of CNG mutant channels	152
Erratum: Isoflurane-lipid emulsion injection as an anticonvulsant and neuroprotectant treatment for nerve agent exposure	151
Editorial: Interplays and Functions of Gaseous Mediators: From Underlying Mechanisms to Therapeutic Approaches in Cardiovascular Diseases	150
Sputum microbe community alterations induced by long-term inhaled corticosteroid use are associated with airway function in chronic obstructive pulmonary disease patients based on metagenomic next-gen	150
RRx-001 Exerts Neuroprotection Against LPS-Induced Microglia Activation and Neuroinflammation Through Disturbing the TLR4 Pathway	149

Impact of domiciliary administration of NSAIDs on COVID-19 hospital outcomes: an unCoVer analysis	149
AduCPI2 alleviates MSU-induced acute gouty arthritis in mice by inhibiting cathepsin S and the C5a-C5aR1 axis	143
Editorial: Methods in predictive toxicology 2023	138
Efficacy and safety of Abelmoschus moschatus capsules combined with tripterygium glycoside tablets on diabetic nephropathy: A systematic review and meta-analysis	134
Integrating single-cell RNA-seq, bulk RNA-seq and network pharmacology reveals protective effect of salidroside in peritoneal dialysis-associated peritoneal fibrosis	131
Corrigendum: Shu-Xie decoction alleviates oxidative stress and colon injury in acute sleep-deprived mice by suppressing p62/KEAP1/NRF2/HO1/NQO1 signaling	131
Plasma calcitonin gene-related peptide and nitric oxide predict therapeutic response to amlodipine in pediatric primary hypertension	130
Associations between ionomic profile and metabolic abnormalities in a murine model of sodium sulfide induced alopecia areata	128
Nodosin Exerts an Anti-Colorectal Cancer Effect by Inhibiting Proliferation and Triggering Complex Cell Death in Vitro and in Vivo	126
Safety evaluation of medroxyprogesterone acetate: a pharmacovigilance analysis using FDA adverse event reporting system data	126
Differences in right ventricular function and response to targeted therapy between patients with IPAH and PAH-CHD	125
Long-term administration of bumetanide improve functional recovery after spinal cord injury in rats	125
Editorial: Utilizing omics strategies to discover new drug targets for cancers	123
Role of ferroptosis in atrial fibrillation: a review	123
Effect of Fu Zheng Jie Du Formula on outcomes in patients with severe pneumonia receiving prone ventilation: a retrospective cohort study	122
The functional significance of vascular DNA hypermethylation in atherosclerosis: a historical perspective	121
CDFA: Calibrated deep feature aggregation for screening synergistic drug combinations	116
Potential efficacy and mechanisms of icariin for the animal model of osteonecrosis of the femoral head	116
Does preterm birth increase the initiation of antidepressant use during the postpartum? A population-based investigation	116
Chemical synthesis of a reported p47phox/p22phox inhibitor and characterization of its instability and irreproducible activity	115
Case Report: Rhabdomyolysis secondary to vildagliptin overdose in a suicidal attempt: A case report and brief literature review	114
Potential mechanisms of Lian-Zhi-Fan solution for TNBS-induced ulcerative colitis in rats via a metabolomics approach	113
Interleukin 22 and its association with neurodegenerative disease activity	109
Naoxintong capsule for treating cardiovascular and cerebrovascular diseases: from bench to bedside	108
Development of a vaccine against the synthetic opioid U-47700	102
Association between antihypertensive drugs and oral cancer: a drug target Mendelian randomization study	102
Investigation of anti-depression effects and potential mechanisms of the ethyl acetate extract of Cynomorium songaricum Rupr. through the integration of in vivo experiments, LC-MS/MS chemical analysis	100
Survival analysis of a 16-year cohort of follicular lymphoma patients receiving systemic treatment in Brazil	100
Research hotspots and trend analysis of cell transplantation in traumatic spinal cord injury: a bibliometric and visualized analysis	100
Wenshen-Jianpi prescription, a Chinese herbal medicine, improves visceral hypersensitivity in a rat model of IBS-D by regulating the MEK/ERK signal pathway	99
Editorial: Women in nanomedicine	98
Patient-Patient Similarity-Based Screening of a Clinical Data Warehouse to Support Ciliopathy Diagnosis	97
Identification of highly effective inhibitors against SARS-CoV-2 main protease: From virtual screening to in vitro study	97
Healthcare professional perspectives on medication challenges in the post-stroke patient	96
Dioscin Reduces Vascular Damage in the Retina of db/db Mice by Inhibiting the VEGFA Signaling Pathway	93
The Protective Effects of Lipid-Lowering Agents on Cardiovascular Disease and Mortality in Maintenance Dialysis Patients: Propensity Score Analysis of a Population-Based Cohort Study	93
Comparison of pharmacokinetics and safety between CE-fosphenytoin sodium, fosphenytoin sodium, and phenytoin sodium after intravenous and intramuscular administration in healthy volunteers	92
Corrigendum: Editorial: The mechanisms of action of anti-SARS-CoV-2 drugs	92
Potential Treat-to-Target Approach for Methamphetamine Use Disorder: A Pilot Study of Adenosine 2A Receptor Antagonist With Positron Emission Tomography	92
Editorial: Leukocyte biology and muscle pathology: Leukocytes as potential targets to control muscle inflammation, mass, and pain	91
Traditional Chinese Medicine formula Dai-Zong-Fang alleviating hepatic steatosis in db/db mice via gut microbiota modulation	91
Identification of potential quality markers of Zishen Yutai pill based on spectrum–effect relationship analysis	91
Editorial: Evolution of phytochemicals and phytotherapies in the treatment and management of cancer: targeted strategies in cancer precision medicine	90
Bibliometric and visualized analysis of sodium–Glucose cotransporter 2 inhibitors	89
Comparative study of the effects of the three kinds of Kampo-hozai: Ninjinyoeito, Hochuekkito, and Juzentaihoto on anxious and low sociability behavior using NPY-knockout zebrafish	88
Investigating the therapeutic potential of hesperidin targeting CRISP2 in intervertebral disc degeneration and cancer risk mitigation	88
Drug-drug interactions between antithrombotics and direct-acting antivirals in hepatitis C virus (HCV) patients: A brief, updated report	88
Inhibitory effects of calcium channel blockers nisoldipine and nimodipine on ivacaftor metabolism and their underlying mechanism	88
Editorial: Genomic discoveries and pharmaceutical development in urologic tumors	87
Non-aromatizable androgens modulate the lipopolysaccharide induced expression of the P2X7 receptor in human adipocytes	87

Consideration in Randomized Placebo-Controlled Trial on Neck Pain to Avoid the Placebo Effect in Analgesic Action	86
Preventive beneficial effects of cannabidiol in a reserpine-induced progressive model of parkinsonism	85
Cost-utility analysis of using paliperidone palmitate in schizophrenia in China	85
Retraction: CXCL6 promotes renal interstitial fibrosis in diabetic nephropathy by activating JAK/STAT3 signaling pathway	84
Metabolic Profiling Analysis of the Effect and Mechanism of Gushiling Capsule in Rabbits With Glucocorticoid-Induced Osteonecrosis of the Femoral Head	83
Significance of LRFN4 in prognosis and tumor microenvironment of lung adenocarcinoma	83
Pterostilbene mitigates experimental pulmonary arterial hypertension by inhibiting endothelial-to-mesenchymal transition	83
Editorial: Advances on targeted nanomedicines for atherosclerosis	82
Erratum: Exploring the pharmacological action mechanism of Ligusticum Chuanxiong-Piper Longum couplet medicines on the treatment of migraine based on network pharmacology	82