OOIR: Observatory of International Research

Papers

(The H4-Index of Frontiers in Pharmacology is 82. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2022-05-01 to 2026-05-01.)

Article	Citations
Association between hyperuricemia and all-cause mortality in people taken Statins: a retrospective cohort study	495
pH-induced conformational changes in the selectivity filter of a potassium channel lead to alterations in its selectivity and permeation properties	402
D-cycloserine effects on COPD and depression in a murine experimental model	368
GraphTransNet: predicting epilepsy-related genes using a graph-augmented protein language model	338
Unraveling the pathogenic mechanism of a novel filamin a frameshift variant in periventricular nodular heterotopia	336
Quantifying the integrated physiological effects of endothelin-1 on cardiovascular and renal function in healthy subjects: a mathematical modeling analysis	316
Editorial: Chronic pain: what is the mechanism?	297
Long-term clinical course and outcomes of patients with microscopic polyangiitis-associated interstitial lung disease	272
Time trends and regional variations in prices of anticancer medicines in China	260
Editorial: Impact of anesthetics on cancer behavior and outcome	240
Unlocking cellular traffic jams: olive oil-mediated rescue of CNG mutant channels	211
Editorial: Interplays and Functions of Gaseous Mediators: From Underlying Mechanisms to Therapeutic Approaches in Cardiovascular Diseases	201
Impact of domiciliary administration of NSAIDs on COVID-19 hospital outcomes: an unCoVer analysis	195
Editorial: Methods in predictive toxicology 2023	187
Associations between ionomic profile and metabolic abnormalities in a murine model of sodium sulfide induced alopecia areata	173
Nodosin Exerts an Anti-Colorectal Cancer Effect by Inhibiting Proliferation and Triggering Complex Cell Death in Vitro and in Vivo	172
Differences in right ventricular function and response to targeted therapy between patients with IPAH and PAH-CHD	169
Editorial: Utilizing omics strategies to discover new drug targets for cancers	165
Effect of Fu Zheng Jie Du Formula on outcomes in patients with severe pneumonia receiving prone ventilation: a retrospective cohort study	158
The functional significance of vascular DNA hypermethylation in atherosclerosis: a historical perspective	158
Potential efficacy and mechanisms of icariin for the animal model of osteonecrosis of the femoral head	155
Case Report: Rhabdomyolysis secondary to vildagliptin overdose in a suicidal attempt: A case report and brief literature review	154
Development of a vaccine against the synthetic opioid U-47700	140
Research hotspots and trend analysis of cell transplantation in traumatic spinal cord injury: a bibliometric and visualized analysis	135
Association between antihypertensive drugs and oral cancer: a drug target Mendelian randomization study	135

Survival analysis of a 16-year cohort of follicular lymphoma patients receiving systemic treatment in Brazil	134
Editorial: Women in nanomedicine	131
Identification of highly effective inhibitors against SARS-CoV-2 main protease: From virtual screening to in vitro study	129
Comparison of pharmacokinetics and safety between CE-fosphenytoin sodium, fosphenytoin sodium, and phenytoin sodium after intravenous and intramuscular administration in healthy volunteers	128
Traditional Chinese Medicine formula Dai-Zong-Fang alleviating hepatic steatosis in db/db mice via gut microbiota modulation	118
Editorial: Evolution of phytochemicals and phytotherapies in the treatment and management of cancer: targeted strategies in cancer precision medicine	116
Editorial: Leukocyte biology and muscle pathology: Leukocytes as potential targets to control muscle inflammation, mass, and pain	116
Drug-drug interactions between antithrombotics and direct-acting antivirals in hepatitis C virus (HCV) patients: A brief, updated report	114
Non-aromatizable androgens modulate the lipopolysaccharide induced expression of the P2X7 receptor in human adipocytes	113
Cost-utility analysis of using paliperidone palmitate in schizophrenia in China	111
Consideration in Randomized Placebo-Controlled Trial on Neck Pain to Avoid the Placebo Effect in Analgesic Action	111
Significance of LRFN4 in prognosis and tumor microenvironment of lung adenocarcinoma	108
Influence of the ABCB1-rs1045642 gene polymorphism on blood drug concentration in voriconazole-treated patients with severe invasive fungal infection	107
Editorial: Advances on targeted nanomedicines for atherosclerosis	107
A retrospective analysis of factors associated with the length of hospital stay in COVID-19 patients treated with Nirmatrelvir / Ritonavir	107
Case Report: Neurofilament light chain in the follow up of progressive multifocal leukoencephalopathy in a patient with multiple sclerosis treated with ocrelizumab	106
Evaluation of variable new antigen receptors (vNARs) as a novel cathepsin S (CTSS) targeting strategy	105
Transcriptome analysis revealed the genes and major pathways involved in prunetrin treated hepatocellular carcinoma cells	104
Androgen receptor inhibitor ameliorates pulmonary arterial hypertension by enhancing the apoptosis level through suppressing the Notch3/Hes5 pathway	102
Inhibition of retinal neovascularization by Dendrobium polysaccharides: a review	102
Case report: Dezocine’s rapid and sustained antidepressant effects	101
Cymensifin A: a promising pharmaceutical candidate to defeat lung cancer via cellular reactive oxygen species-mediated apoptosis	101
A Multicenter Study of 239 Patients Aged Over 70 Years With Diffuse Large B-Cell Lymphoma in China	99
Development and therapeutic evaluation of 5D3(CC-MLN8237)3.2 antibody-theranostic conjugates for PSMA-positive prostate cancer therapy	98
A nano-preparation approach to enable the delivery of daphnoretin to potentiate the therapeutical efficacy in hepatocellular cancer	98
Menisoxoisoaporphine A, a novel oxoisoaporphine alkaloid from Menispermi Rhizoma, inhibits inflammation by targeting PDE4B	97
Male mice treated with combined anti-fibrotic therapeutics, IPW5371 and tadalafil, are predisposed to adverse cardiovascular events	96
The clinically applied PARP inhibitor talazoparib ameliorates imiquimod-induced psoriasis in mice without reducing skin inflammation	96
Which is the optimal choice in lipid-lowering therapy for reducing major cardiovascular events? a network meta-analysis	95
The clinical value of screening for acetaminophen in all patients with intentional overdose or altered mental status suspected to be secondary to overdose	95
Opportunities and challenges in the treatment of IgA nephropathy	95
Research Progress of RNA Methylation Modification in Colorectal Cancer	95
In vitro effect of hydroxychloroquine on pluripotent stem cells and their cardiomyocytes derivatives	94
Network pharmacology-based and experimental identification of the effects of Renshen Yangrong decoction on myocardial infarction	93
Tailoring second-line or above therapy for patients with advanced or metastatic gastric cancer: A multicenter real-world study	92
The macrocyclic lactone oxacyclododecindione reduces fibrosis progression	91
Cost-effectiveness of empagliflozin for the treatment of heart failure: a systematic review	91
Editorial: Streaming inflammation: From damage to healing and resilience–Volume II	90
Prediction of Immune-Related Adverse Events Induced by Immune Checkpoint Inhibitors With a Panel of Autoantibodies: Protocol of a Multicenter, Prospective, Observational Cohort Study	89
Inhibition of PPARγ by BZ26, a GW9662 derivate, attenuated obesity-related breast cancer progression by inhibiting the reprogramming of mature adipocytes into to cancer associate adipocyte-like cells	89
In situ sustained release of icariin from injectable thermosensitive PLGA-PEG-PLGA hydrogels combined with core decompression for steroid-induced osteonecrosis of femoral head	88
Pharmacokinetics and absorption mechanism of tandospirone citrate	87
Natural drugs targeting inflammation pathways can be used to treat atherosclerosis	86
Comparative efficacy of commercial Chinese polyherbal preparation for coronary microvascular dysfunction: a systematic review and network meta-analysis of randomized controlled trials	86
Ophiopogonin D increase apoptosis by activating p53 via ribosomal protein L5 and L11 and inhibiting the expression of c-Myc via CNOT2	85
Commentary: Iridoids derived from Valeriana jatamansi jones alleviates neuroinflammation and blood spinal cord barrier permeability after spinal cord injury by activating the Nrf2/HO-1 signaling pathw	85
Endothelium glutamate receptors in brain pathology	85
Research Progress of Chinese Herbal Medicine Intervention in Renal Interstitial Fibrosis	84
Dopaminergic REST is implicated in the tamoxifen-induced neuroprotection against manganese toxicity in female mice	84
Cytotoxicity and reversal effect of sertraline, fluoxetine, and citalopram on MRP1- and MRP7-mediated MDR	84

Phyllanthus emblica aqueous extract retards hepatic steatosis and fibrosis in NAFLD mice in association with the reshaping of intestinal microecology	84
Cardiovascular toxicities associated with chimeric antigen receptor T-cell therapy	84
Screening of anti-heart failure active compounds from fangjihuangqi decoction in verapamil-induced zebrafish model by anti-heart failure index approach	83
Investigation of anti-nociceptive, anti-inflammatory potential and ADMET studies of pure compounds isolated from Isodon rugosus Wall. ex Benth	83
Cost-effectiveness analysis of lenvatinib plus pembrolizumab compared with chemotherapy for patients with previously treated mismatch repair proficient advanced endometrial cancer in China	83
Editorial: Genomic discoveries and pharmaceutical development in urologic tumors	82
HtrA2/Omi: potential therapeutic targets for neurodegenerative diseases	82
The essential role of YAP in ERα36-mediated proliferation and the epithelial-mesenchymal transition in MCF-7 breast cancer cells	82