OOIR: Observatory of International Research

Papers

(The H4-Index of Frontiers in Pharmacology is 78. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-06-01 to 2025-06-01.)

Article	Citations
Pre- and post-chemotherapy spermatogenesis in male patients with malignant bone and soft tissue tumors	557
Individualized, dynamic, and full-course vancomycin dosing prediction: a study on the customized dose model	365
Metabolite-assisted models improve risk prediction of coronary heart disease in patients with diabetes	325
Potential of resveratrol in the treatment of interstitial lung disease	307
Editorial: Women in nanomedicine	266
Title: Understanding a Low Vitamin D State in the Context of COVID-19	264
The forensic aspects of suicide and neurotrophin factors: a research study	236
Understanding Stakeholder Views Regarding the Design of an Intervention Trial to Reduce Anticholinergic Burden: A Qualitative Study	217
Strategies for salvage therapy post CAR-T therapy failure in refractory/relapsed multiple myeloma patients	179
RRx-001 Exerts Neuroprotection Against LPS-Induced Microglia Activation and Neuroinflammation Through Disturbing the TLR4 Pathway	177
Overview of Cannabis including Kampo Medicine and Therapy for Treatment of Dementia: A Review	162
In vitro effect of hydroxychloroquine on pluripotent stem cells and their cardiomyocytes derivatives	161
Harnessing the power of natural alkaloids: the emergent role in epilepsy therapy	158
Several major herb pairs containing Coptidis rhizoma: a review of key traditional uses, constituents and compatibility effects	157
Cost-effectiveness analysis of lenvatinib plus pembrolizumab compared with chemotherapy for patients with previously treated mismatch repair proficient advanced endometrial cancer in China	152
Plant Source Derived Compound Exhibited In Silico Inhibition of Membrane Glycoprotein In SARS-CoV-2: Paving the Way to Discover a New Class of Compound For Treatment of COVID-19	149
Improvement of solubility, dissolution, and bioavailability of phenytoin intercalated in Mg-Al layered double hydroxide	148
Case report: Dezocine’s rapid and sustained antidepressant effects	146
Reynoutria japonica Houtt for Acute Respiratory Tract Infections in Adults and Children: A Systematic Review	143
Transcriptome analysis revealed the role of mTOR and MAPK signaling pathways in the white strain of Hypsizygus marmoreus extracts-induced cell death of human hepatoma Hep3B cells	141
Exploration of the Mechanism of Salvianolic Acid for Injection Against Ischemic Stroke: A Research Based on Computational Prediction and Experimental Validation	140
T-type calcium channel modulation by hydrogen sulfide in neuropathic pain conditions	139
Comprehensive Analysis of Chemical Structures That Have Been Tested as CFTR Activating Substances in a Publicly Available Database CandActCFTR	138
Potential Treat-to-Target Approach for Methamphetamine Use Disorder: A Pilot Study of Adenosine 2A Receptor Antagonist With Positron Emission Tomography	136
Editorial: Autoimmune and Inflammatory Rheumatic Diseases: Identifying Biomarkers of Response to Therapy With Biologics	133

Comparative study of the effects of the three kinds of Kampo-hozai: Ninjinyoeito, Hochuekkito, and Juzentaihoto on anxious and low sociability behavior using NPY-knockout zebrafish	129
Cost-utility analysis of using paliperidone palmitate in schizophrenia in China	126
Identification of potential quality markers of Zishen Yutai pill based on spectrum–effect relationship analysis	124
Traditional Chinese Medicine formula Dai-Zong-Fang alleviating hepatic steatosis in db/db mice via gut microbiota modulation	123
Consideration in Randomized Placebo-Controlled Trial on Neck Pain to Avoid the Placebo Effect in Analgesic Action	117
Editorial: Leukocyte biology and muscle pathology: Leukocytes as potential targets to control muscle inflammation, mass, and pain	117
The therapeutic potential of natural metabolites in targeting endocrine-independent HER-2-negative breast cancer	114
Editorial: Therapeutic drug monitoring (TDM): a useful tool for pediatric pharmacology applied to routine clinical practice, Volume II	113
Development of Synergy-Based Combination for Learning and Memory Using in vitro, in vivo and TLC-MS-Bioautographic Studies	112
Editorial: Oral mucosa and disorders: from drug discovery to development and translation	112
Network pharmacology and experimental verification-based strategy to explore the underlying mechanism of Liu Jun An Wei formula in the treatment of gastrointestinal reactions caused by chemotherapy fo	108
Impact of domiciliary administration of NSAIDs on COVID-19 hospital outcomes: an unCoVer analysis	106
Effects of public reporting of prescription indicators on patient choices: evidence from propensity scores matching	106
Sex, Pramipexole and Tiagabine Affect Behavioral and Hormonal Response to Traumatic Stress in a Mouse Model of PTSD	103
Comparison of pharmacokinetics and safety between CE-fosphenytoin sodium, fosphenytoin sodium, and phenytoin sodium after intravenous and intramuscular administration in healthy volunteers	102
Title: P2x7 Receptor Activation and Estrogen Status Drive Neuroinflammatory Mechanisms in a Rat Model for Dry Eye	101
Apple pectin-based Zataria multiflora essential oil (ZEO) nanoemulsion: An approach to enhance ZEO DNA damage induction in breast cancer cells as in vitro and in silico studies reveal	101
Editorial: Interplays and Functions of Gaseous Mediators: From Underlying Mechanisms to Therapeutic Approaches in Cardiovascular Diseases	101
Liu Shen Capsule Alters Airway Microbiota Composition and Metabolite Profiles in Healthy Humans	100
Editorial: Streaming inflammation: From damage to healing and resilience–Volume II	100
Sputum microbe community alterations induced by long-term inhaled corticosteroid use are associated with airway function in chronic obstructive pulmonary disease patients based on metagenomic next-gen	100
Antisense Oligonucleotide-Based Therapy on miR-181a-5p Alleviates Cartilage Degradation of Temporomandibular Joint Osteoarthritis via Promoting SIRT1	100
A Multicenter Study of 239 Patients Aged Over 70 Years With Diffuse Large B-Cell Lymphoma in China	98
Cytotoxicity and reversal effect of sertraline, fluoxetine, and citalopram on MRP1- and MRP7-mediated MDR	95
In vivo pharmacokinetics of Glycyrrhiza uralensis polysaccharides	95
Hepatoprotective Efficacy and Interventional Mechanism of Qijia Rougan Decoction in Liver Fibrosis	94
Editorial: Evolution of phytochemicals and phytotherapies in the treatment and management of cancer: targeted strategies in cancer precision medicine	94
Does preterm birth increase the initiation of antidepressant use during the postpartum? A population-based investigation	94
Experience of a Strategy Including CYP2C19 Preemptive Genotyping Followed by Therapeutic Drug Monitoring of Voriconazole in Patients Undergoing Allogenic Hematopoietic Stem Cell Transplantation	93
Extracellular vesicles mediate biological information delivery: A double-edged sword in cardiac remodeling after myocardial infarction	93
Editorial: Impact of anesthetics on cancer behavior and outcome	90
Association between hyperuricemia and all-cause mortality in people taken Statins: a retrospective cohort study	90
Editorial: Advances on targeted nanomedicines for atherosclerosis	90
Editorial: Dissecting Traditional Medicine via Chemical and Biochemical Techniques: Advanced Analytics and Novel Paradigms	89
Canagliflozin Prevents Lipid Accumulation, Mitochondrial Dysfunction, and Gut Microbiota Dysbiosis in Mice With Diabetic Cardiovascular Disease	88
Dioscin Reduces Vascular Damage in the Retina of db/db Mice by Inhibiting the VEGFA Signaling Pathway	87
Editorial: Pharmacogenetics and pharmacogenomics in Latin America: ethnic variability, new insights in advances and perspectives: a RELIVAF-CYTED initiative, Volume II	87
Clinical study of ganshuang granule combined with tenofovir in the treatment of chronic hepatitis B complicated with nonalcoholic fatty liver disease	86
Cost-effectiveness of empagliflozin for the treatment of heart failure: a systematic review	86
Escitalopram oxalate-loaded chitosan nanoparticle in situ gel formulation intended for direct nose-to-brain delivery: in vitro, ex vivo, and in vivo pharmacokinetic evaluation	85
Olmesartan Attenuates Single-Lung Ventilation Induced Lung Injury via Regulating Pulmonary Microbiota	84
Identification of highly effective inhibitors against SARS-CoV-2 main protease: From virtual screening to in vitro study	83
Pterostilbene Alleviates Cholestasis by Promoting SIRT1 Activity in Hepatocytes and Macrophages	83
The Function of Natural Polysaccharides in the Treatment of Ulcerative Colitis	83
Qishen Granule (QSG) Inhibits Monocytes Released From the Spleen and Protect Myocardial Function via the TLR4-MyD88-NF-κB p65 Pathway in Heart Failure Mice	83
Editorial: Methods in predictive toxicology 2023	82
Post-marketing safety surveillance of dalfampridine for multiple sclerosis using FDA adverse event reporting system	81
Corrigendum: Shu-Xie decoction alleviates oxidative stress and colon injury in acute sleep-deprived mice by suppressing p62/KEAP1/NRF2/HO1/NQO1 signaling	80
New use of an old drug: mechanism of oseltamivir phosphate inhibiting liver cancer through regulation of lipophagy via NEU1	80
Editorial: Utilizing omics strategies to discover new drug targets for cancers	79

Corrigendum: Xenon attenuated neonatal lipopolysaccharide exposure induced neuronal necroptosis and subsequently improved cognition in juvenile rats	79
Erratum: Isoflurane-lipid emulsion injection as an anticonvulsant and neuroprotectant treatment for nerve agent exposure	78
Corrigendum: Sanguisorba officinalis L. Suppresses Triple-Negative Breast Cancer Metastasis by Inhibiting Late-Phase Autophagy via Hif-1α/Caveolin-1 Signaling	78
Inhibitory effects of calcium channel blockers nisoldipine and nimodipine on ivacaftor metabolism and their underlying mechanism	78
Retraction: CXCL6 promotes renal interstitial fibrosis in diabetic nephropathy by activating JAK/STAT3 signaling pathway	78