Frontiers in Pharmacology

Article	Citations
Application of artificial intelligence large language models in drug target discovery	613
CDFA: Calibrated deep feature aggregation for screening synergistic drug combinations	365
Cannabidiol Inhibits Multiple Ion Channels in Rabbit Ventricular Cardiomyocytes	330
Gut microbiome-mediated mechanisms in aging-related diseases: are probiotics ready for prime time?	310
Effect of age and ICU types on mortality in invasive mechanically ventilated patients with sepsis receiving dexmedetomidine: a retrospective cohort study with propensity score matching	308
Endolysins: a new antimicrobial agent against antimicrobial resistance. Strategies and opportunities in overcoming the challenges of endolysins against Gram-negative bacteria	295
Anti-Inflammatory and Antimicrobial Volatile Oils: Fennel and Cumin Inhibit Neutrophilic Inflammation via Regulating Calcium and MAPKs	252
Experience of a Strategy Including CYP2C19 Preemptive Genotyping Followed by Therapeutic Drug Monitoring of Voriconazole in Patients Undergoing Allogenic Hematopoietic Stem Cell Transplantation	236
Network Pharmacology–Based Identification of Key Mechanisms of Xihuang Pill in the Treatment of Triple-Negative Breast Cancer Stem Cells	189
Opportunities and challenges in the treatment of IgA nephropathy	183
The clinical value of screening for acetaminophen in all patients with intentional overdose or altered mental status suspected to be secondary to overdose	181
Efficacy and safety of sequential immunosuppressive treatment for severe IgA nephropathy: A retrospective study	173
Natural killer cell-related prognosis signature predicts immune response in colon cancer patients	169
Association of LEPTIN and other inflammatory markers with preeclampsia: A systematic review	165
Chrysophanol promotes M2 polarization and inhibits M1 polarization through the NF-κB signaling pathway to attenuate sepsis-associated acute kidney injury	163
Tuo-Min-Ding-Chuan Decoction Alleviate Ovalbumin-Induced Allergic Asthma by Inhibiting Mast Cell Degranulation and Down-Regulating the Differential Expression Proteins	159
Pterostilbene Alleviates Cholestasis by Promoting SIRT1 Activity in Hepatocytes and Macrophages	154
Hermansky-Pudlak Syndrome: Identification of Novel Variants in the Genes HPS3, HPS5, and DTNBP1 (HPS-7)	153
Maresin 1 Attenuates Lipopolysaccharide-Induced Acute Kidney Injury via Inhibiting NOX4/ROS/NF-κB Pathway	150
Microbiome Analysis and Pharmacovigilance After Inhaled Glucocorticoid: Oral Dysbiosis With the Isolation of Three Rothia Species and Subsequent Sjögren’s Syndrome	149
Proteomics Study Reveals the Anti-Depressive Mechanisms and the Compatibility Advantage of Chaihu-Shugan-San in a Rat Model of Chronic Unpredictable Mild Stress	147
Activation of EP4 alleviates AKI-to-CKD transition through inducing CPT2-mediated lipophagy in renal macrophages	139
The Future of Gene Therapy for Transfusion-Dependent Beta-Thalassemia: The Power of the Lentiviral Vector for Genetically Modified Hematopoietic Stem Cells	128
Avens Root (Geum Urbanum L.) Extract Discovered by Target-Based Screening Exhibits Antidiabetic Activity in the Hen’s Egg Test Model and Drosophila melanogaster	128
Asthma Therapies on Pulmonary Tuberculosis Pneumonia in Predominant Bronchiectasis–Asthma Combination	126

Comprehensive Analysis of Chemical Structures That Have Been Tested as CFTR Activating Substances in a Publicly Available Database CandActCFTR	120
Network pharmacology-based and experimental identification of the effects of Renshen Yangrong decoction on myocardial infarction	118
Naoxintong Capsule Alternates Gut Microbiota and Prevents Hyperlipidemia in High-Fat-Diet Fed Rats	117
Inhibition of Gasdermin D-Mediated Pyroptosis Attenuates the Severity of Seizures and Astroglial Damage in Kainic Acid-Induced Epileptic Mice	117
MicroRNA 449a can Attenuate Protective Effect of Urokinase Against Pulmonary Embolism	117
Integrated network pharmacology and experimental analysis unveil multi-targeted effect of 18α- glycyrrhetinic acid against non-small cell lung cancer	116
Effects of the Full Coverage Policy of Essential Medicines on Inequality in Medication Adherence: A Longitudinal Study in Taizhou, China	116
First-Line ICI Monotherapies for Advanced Non-small-cell Lung Cancer Patients With PD-L1 of at Least 50%: A Cost-Effectiveness Analysis	114
Centella asiatica Alters Metabolic Pathways Associated With Alzheimer’s Disease in the 5xFAD Mouse Model of ß-Amyloid Accumulation	112
Icotinib derivatives as tyrosine kinase inhibitors with anti-esophageal squamous carcinoma activity	111
Xuanfei Pingchuan Capsules Ameliorate Autophagy in Human Bronchial Epithelial Cells by Inhibiting p38 Phosphorylation	111
Editorial: Dissecting Traditional Medicine via Chemical and Biochemical Techniques: Advanced Analytics and Novel Paradigms	110
Corrigendum: Sanguisorba officinalis L. Suppresses Triple-Negative Breast Cancer Metastasis by Inhibiting Late-Phase Autophagy via Hif-1α/Caveolin-1 Signaling	110
Bifidobacterium Strains Present Distinct Effects on the Control of Alveolar Bone Loss in a Periodontitis Experimental Model	109
Agriophyllum Oligosaccharides Ameliorate Diabetic Insulin Resistance Through INS-R/IRS/Glut4-Mediated Insulin Pathway in db/db Mice and MIN6 Cells	106
Population pharmacokinetics and dosing optimization of unbound teicoplanin in Chinese adult patients	106
The Transcultural Adaptation and Validation of the Chinese Version of the Duke Anticoagulation Satisfaction Scale	105
The use of African medicinal plants in cancer management	105
Canagliflozin Prevents Lipid Accumulation, Mitochondrial Dysfunction, and Gut Microbiota Dysbiosis in Mice With Diabetic Cardiovascular Disease	104
East Asian Herbal Medicine to Reduce Primary Pain and Adverse Events in Cancer Patients : A Systematic Review and Meta-Analysis With Association Rule Mining to Identify Core Herb Combination	104
Antifungal Drugs and Drug-Induced Liver Injury: A Real-World Study Leveraging the FDA Adverse Event Reporting System Database	103
Liu Shen Capsule Alters Airway Microbiota Composition and Metabolite Profiles in Healthy Humans	100
Wendan decoction in the treatment of nonalcoholic fatty liver disease: A systematic review and meta-analysis	100
Chloroquine and Hydroxychloroquine Use During Pregnancy and the Risk of Adverse Pregnancy Outcomes Using Real-World Evidence	99
Tailoring second-line or above therapy for patients with advanced or metastatic gastric cancer: A multicenter real-world study	99
A New Strategy for Multitarget Drug Discovery/Repositioning Through the Identification of Similar 3D Amino Acid Patterns Among Proteins Structures: The Case of Tafluprost and its Effects on Cardiac Io	98
Cost-effectiveness of empagliflozin for the treatment of heart failure: a systematic review	98
Transcriptome analysis revealed the role of mTOR and MAPK signaling pathways in the white strain of Hypsizygus marmoreus extracts-induced cell death of human hepatoma Hep3B cells	96
Advances in Our Understanding of the Mechanism of Action of Drugs (including Traditional Chinese Medicines) for the Intervention and Treatment of Osteoporosis	96
Effects of Broussonetia papyrifera (L.) L'Hér. ex Vent. fruits water extract on hippocampal neurogenesis in the treatment of APP/PS1 transgenic mice	94
Chronic Administration of COVID-19 Drugs Fluvoxamine and Lopinavir Shortens Action Potential Duration by Inhibiting the Human Ether‐à‐go‐go–Related Gene and Cav1.2	94
Potential role of extracellular granzyme B in wet age-related macular degeneration and fuchs endothelial corneal dystrophy	93
Phyllanthus emblica aqueous extract retards hepatic steatosis and fibrosis in NAFLD mice in association with the reshaping of intestinal microecology	92
Drug-loaded PEG-PLGA nanoparticles for cancer treatment	91
Associations of Fentanyl, Sufentanil, and Remifentanil With Length of Stay and Mortality Among Mechanically Ventilated Patients: A Registry-Based Cohort Study	91
Overview of Cannabis including Kampo Medicine and Therapy for Treatment of Dementia: A Review	88
The macrocyclic lactone oxacyclododecindione reduces fibrosis progression	87
Appropriateness of Antibiotic Prescriptions in Chinese Primary Health Care and the Impact of the COVID-19 Pandemic: A Typically Descriptive and Longitudinal Database Study in Yinchuan City	85
Buyang Huanwu Decoction alleviates cerebral ischemic injury through modulating caveolin-1-mediated mitochondrial quality control	85
Title: P2x7 Receptor Activation and Estrogen Status Drive Neuroinflammatory Mechanisms in a Rat Model for Dry Eye	85
Cannabidiol for neurodegenerative disorders: A comprehensive review	84
Qishen Granule (QSG) Inhibits Monocytes Released From the Spleen and Protect Myocardial Function via the TLR4-MyD88-NF-κB p65 Pathway in Heart Failure Mice	84
Calycosin induces autophagy and apoptosis via Sestrin2/AMPK/mTOR in human papillary thyroid cancer cells	84
Cost-effectiveness analysis of lenvatinib plus pembrolizumab compared with chemotherapy for patients with previously treated mismatch repair proficient advanced endometrial cancer in China	83
Factors influencing plasma concentration of voriconazole and voriconazole- N-oxide in younger adult and elderly patients	83
Effects of Berberine on Atherosclerosis	82
Effect of corticosteroids combined with cyclophosphamide or mycophenolate mofetil therapy for IgA nephropathy with stage 3 or 4 chronic kidney disease: A retrospective cohort study	82
ALG-bFGF Hydrogel Inhibiting Autophagy Contributes to Protection of Blood–Spinal Cord Barrier Integrity via PI3K/Akt/FOXO1/KLF4 Pathway After SCI	82
Editorial: Streaming inflammation: From damage to healing and resilience–Volume II	81
Applications and Biocompatibility of Mesoporous Silica Nanocarriers in the Field of Medicine	80

Phenotype-Based HPLC-Q-TOF-MS/MS Coupled With Zebrafish Behavior Trajectory Analysis System for the Identification of the Antidepressant Components in Methanol Extract of Anshen Buxin Six Pills	79
Potential Natural Small Molecular Compounds for the Treatment of Chronic Obstructive Pulmonary Disease: An Overview	78
Insight Into the Mechanism of Exercise Preconditioning in Ischemic Stroke	77
Polygala tenuifolia and Acorus tatarinowii in the treatment of Alzheimer’s disease: a systematic review and meta-analysis	77
Ethnic Diversity and Warfarin Pharmacogenomics	77
Structural Insight Into Ryanodine Receptor Channelopathies	76
Apple pectin-based Zataria multiflora essential oil (ZEO) nanoemulsion: An approach to enhance ZEO DNA damage induction in breast cancer cells as in vitro and in silico studies reveal	76
A minimal PBPK model to accelerate preclinical development of drugs against tuberculosis	76
A PDE10A inhibitor CPL500036 is a novel agent modulating striatal function devoid of most neuroleptic side-effects	76
Editorial: Pharmacogenetics and pharmacogenomics in Latin America: ethnic variability, new insights in advances and perspectives: a RELIVAF-CYTED initiative, Volume II	76
Natural drugs targeting inflammation pathways can be used to treat atherosclerosis	75
Antisense Oligonucleotide-Based Therapy on miR-181a-5p Alleviates Cartilage Degradation of Temporomandibular Joint Osteoarthritis via Promoting SIRT1	74
Resveratrol Attenuates High Glucose-Induced Osteoblast Dysfunction via AKT/GSK3β/FYN-Mediated NRF2 Activation	74
Pterostilbene in Combination With Mitochondrial Cofactors Improve Mitochondrial Function in Cellular Models of Mitochondrial Diseases	74
Does preterm birth increase the initiation of antidepressant use during the postpartum? A population-based investigation	73
Mupirocin Promotes Wound Healing by Stimulating Growth Factor Production and Proliferation of Human Keratinocytes	73
Ginsenoside Rb1 improves intestinal aging via regulating the expression of sirtuins in the intestinal epithelium and modulating the gut microbiota of mice	73
Effects of Dexmedetomidine on Immune Cells: A Narrative Review	73
mPEG-PDLLA Micelles Potentiate Docetaxel for Intraperitoneal Chemotherapy in Ovarian Cancer Peritoneal Metastasis	73
Pharmacokinetics and absorption mechanism of tandospirone citrate	72
Caveolin-1 Regulates Cellular Metabolism: A Potential Therapeutic Target in Kidney Disease	72
Efficacy analysis of splint combined with platelet-rich plasma in the treatment of temporomandibular joint osteoarthritis	71
Case Report: Rhabdomyolysis secondary to vildagliptin overdose in a suicidal attempt: A case report and brief literature review	70
AI-assisted literature exploration of innovative Chinese medicine formulas	70
Chemical synthesis of a reported p47phox/p22phox inhibitor and characterization of its instability and irreproducible activity	70
A Novel Compound, Tanshinol Borneol Ester, Ameliorates Pressure Overload-Induced Cardiac Hypertrophy by Inhibiting Oxidative Stress via the mTOR/β-TrCP/NRF2 Pathway	69
Integrated Analysis of the Cecal Microbiome and Plasma Metabolomics to Explore NaoMaiTong and Its Potential Role in Changing the Intestinal Flora and Their Metabolites in Ischemic Stroke	69
Protective role of curcumin in disease progression from non-alcoholic fatty liver disease to hepatocellular carcinoma: a meta-analysis	69
Network pharmacology and experimental verification-based strategy to explore the underlying mechanism of Liu Jun An Wei formula in the treatment of gastrointestinal reactions caused by chemotherapy fo	69
Post-marketing safety surveillance of dalfampridine for multiple sclerosis using FDA adverse event reporting system	69
Potential mechanisms of Lian-Zhi-Fan solution for TNBS-induced ulcerative colitis in rats via a metabolomics approach	68
Interleukin 22 and its association with neurodegenerative disease activity	67
Hepatoprotective Efficacy and Interventional Mechanism of Qijia Rougan Decoction in Liver Fibrosis	67
Molecular determinants of TRPM8 function: key clues for a cool modulation	67
The role of NLRP3 inflammasome in hepatocellular carcinoma	66
Cytotoxicity and reversal effect of sertraline, fluoxetine, and citalopram on MRP1- and MRP7-mediated MDR	66
Brain-Derived Neurotrophic Factor-Mediated Neuroprotection in Glaucoma: A Review of Current State of the Art	65
Post-myocardial infarction fibrosis: Pathophysiology, examination, and intervention	65
Naoxintong capsule for treating cardiovascular and cerebrovascular diseases: from bench to bedside	65
Interaction and potential mechanisms between atorvastatin and voriconazole, agents used to treat dyslipidemia and fungal infections	64
Ethnobotanical study of medicinal plants used by the people of Mosop, Nandi County in Kenya	64
Integrated analysis of Dendrobium nobile extract Dendrobin A against pancreatic ductal adenocarcinoma based on network pharmacology, bioinformatics, and validation experiments	64
Development of a vaccine against the synthetic opioid U-47700	64
Anticancer effects of OSW-1 on glioma cells via regulation of the PI3K/AKT signal pathway: A network pharmacology approach and experimental validation in vitro and in vivo	63
Investigation of anti-depression effects and potential mechanisms of the ethyl acetate extract of Cynomorium songaricum Rupr. through the integration of in vivo experiments, LC-MS/MS chemical analysis	63
Association between antihypertensive drugs and oral cancer: a drug target Mendelian randomization study	63
The Role of Traditional Plant Knowledge in the Fight Against Infectious Diseases: A Meta-Analytic Study in the Catalan Linguistic Area	63
Title: Understanding a Low Vitamin D State in the Context of COVID-19	63
Research hotspots and trend analysis of cell transplantation in traumatic spinal cord injury: a bibliometric and visualized analysis	62
Emerging Significance of Ginsenosides as Potentially Reversal Agents of Chemoresistance in Cancer Therapy	62
The therapeutic potential of natural metabolites in targeting endocrine-independent HER-2-negative breast cancer	62
Pharmacogenetic and pharmacokinetic factors for dexmedetomidine-associated hemodynamic instability in pediatric patients	62
Network pharmacology and transcriptomics reveal the mechanisms of FFBZL in the treatment of oral squamous cell carcinoma	62
HIV Protease Inhibitors and Insulin Sensitivity: A Systematic Review and Meta-Analysis of Randomized Controlled Trials	61
Prescription medication use of United States military service members by therapeutic classification	61
LINC01559 drives osimertinib resistance in NSCLC through a ceRNA network regulating miR-320a/IGF2BP3 axis	61
Gegen Qinlian decoction prevents post-ERCP pancreatitis by regulating NLRP3 inflammasome-mediated pyroptosis	61
Editorial: Women in nanomedicine	60
Mechanism Underlying Acupuncture Therapy in Spinal Cord Injury: A Narrative Overview of Preclinical Studies	60
Identification of highly effective inhibitors against SARS-CoV-2 main protease: From virtual screening to in vitro study	60
Drug-related problems among transfusion-dependent thalassemia patients: A real-world evidence study	60
Immune Effect of Active Components of Traditional Chinese Medicine on Triple-Negative Breast Cancer	60
The Efficiency of Hydroxychloroquine for the Treatment of Primary Sjögren’s Syndrome: A Systematic Review and Meta-Analysis	60
Wenshen-Jianpi prescription, a Chinese herbal medicine, improves visceral hypersensitivity in a rat model of IBS-D by regulating the MEK/ERK signal pathway	60
Efficacy of Intra-Arterial Plus Intravesical Chemotherapy for High-Risk Non-Muscle-Invasive Bladder Cancer: A Pooled Analysis	59
Baicalein Ameliorates Myocardial Ischemia Through Reduction of Oxidative Stress, Inflammation and Apoptosis via TLR4/MyD88/MAPKS/NF-κB Pathway and Regulation of Ca2+ Homeostasis by L-type Ca2+ Channel	59
Healthcare professional perspectives on medication challenges in the post-stroke patient	59
Short-Chain Naphthoquinone Protects Against Both Acute and Spontaneous Chronic Murine Colitis by Alleviating Inflammatory Responses	59
A Comprehensive Review of BET Protein Biochemistry, Physiology, and Pathological Roles	59
Patient-Patient Similarity-Based Screening of a Clinical Data Warehouse to Support Ciliopathy Diagnosis	59
Absorption, Metabolism, and Excretion of ACT-1004-1239, a First-In-Class CXCR7 Antagonist: In Vitro, Preclinical, and Clinical Data	58
A Betulinic Acid Derivative, BA5, Induces G0/G1 Cell Arrest, Apoptosis Like-Death, and Morphological Alterations in Leishmania sp	58
The Protective Effects of Lipid-Lowering Agents on Cardiovascular Disease and Mortality in Maintenance Dialysis Patients: Propensity Score Analysis of a Population-Based Cohort Study	58
Dioscin Reduces Vascular Damage in the Retina of db/db Mice by Inhibiting the VEGFA Signaling Pathway	58
SARS-CoV-2 infection dysregulates the expression of clinically relevant drug metabolizing enzymes in Vero E6 cells and membrane transporters in human lung tissues	58
The essential role of YAP in ERα36-mediated proliferation and the epithelial-mesenchymal transition in MCF-7 breast cancer cells	57
CXCR2 Small-Molecule Antagonist Combats Chemoresistance and Enhances Immunotherapy in Triple-Negative Breast Cancer	57
Comparison of pharmacokinetics and safety between CE-fosphenytoin sodium, fosphenytoin sodium, and phenytoin sodium after intravenous and intramuscular administration in healthy volunteers	57
Identification of potential quality markers of Zishen Yutai pill based on spectrum–effect relationship analysis	57
Chinese Herbal Medicine for Primary Liver Cancer Therapy: Perspectives and Challenges	57

Olmesartan Attenuates Single-Lung Ventilation Induced Lung Injury via Regulating Pulmonary Microbiota	57
Association of EGFR Tyrosine Kinase Inhibitor Treatment With Progression-Free Survival Among Taiwanese Patients With Advanced Lung Adenocarcinoma and EGFR Mutation	57
Potential targets and applications of nanodrug targeting myeloid cells in osteosarcoma for the enhancement of immunotherapy	57
Investigation of anti-nociceptive, anti-inflammatory potential and ADMET studies of pure compounds isolated from Isodon rugosus Wall. ex Benth	57
Potential Treat-to-Target Approach for Methamphetamine Use Disorder: A Pilot Study of Adenosine 2A Receptor Antagonist With Positron Emission Tomography	57
Corrigendum: Editorial: The mechanisms of action of anti-SARS-CoV-2 drugs	57
Natural products from plants and microorganisms: Novel therapeutics for chronic kidney disease via gut microbiota regulation	57
An Update on the Effects of Probiotics on Gastrointestinal Cancers	57
Machine learning methods for propensity and disease risk score estimation in high-dimensional data: a plasmode simulation and real-world data cohort analysis	56
Screening of Microbial Natural Products and Biological Evaluation of Trichomicin as Potential Anti-Cytokine Storm Agents	56
Advancing the use of real world evidence in health technology assessment: insights from a multi-stakeholder workshop	56
Pichia pastoris secreted peptides crossing the blood-brain barrier and DSIP fusion peptide efficacy in PCPA-induced insomnia mouse models	56
Ion Channel Dysfunction and Neuroinflammation in Migraine and Depression	56
Editorial: Leukocyte biology and muscle pathology: Leukocytes as potential targets to control muscle inflammation, mass, and pain	56
Circadian Dependence of the Acute Immune Response to Myocardial Infarction	56
Traditional Chinese Medicine formula Dai-Zong-Fang alleviating hepatic steatosis in db/db mice via gut microbiota modulation	56
The Novel Antioxidant Compound JSH-23 Prevents Osteolysis by Scavenging ROS During Both Osteoclastogenesis and Osteoblastogenesis	56
Hypoglycemic effects of dendrobium officinale leaves	56
Improvement of solubility, dissolution, and bioavailability of phenytoin intercalated in Mg-Al layered double hydroxide	56
Neuroprotective and Anti-Inflammatory Effect of Pterostilbene Against Cerebral Ischemia/Reperfusion Injury via Suppression of COX-2	56
Editorial: Evolution of phytochemicals and phytotherapies in the treatment and management of cancer: targeted strategies in cancer precision medicine	55
Protective effects of insulin on dry eye syndrome via TLR4/NF-κB pathway: based on network pharmacology and in vitro experiments validation	55
The role of l-leucovorin uptake and metabolism in the modulation of 5-fluorouracil efficacy and antifolate toxicity	55
Natural Compounds: A Hopeful Promise as an Antibiofilm Agent Against Candida Species	55
Bibliometric and visualized analysis of sodium–Glucose cotransporter 2 inhibitors	55
Neuroinflammation alters GABAergic neurotransmission in hyperammonemia and hepatic encephalopathy, leading to motor incoordination. Mechanisms and therapeutic implications	55
Comparative study of the effects of the three kinds of Kampo-hozai: Ninjinyoeito, Hochuekkito, and Juzentaihoto on anxious and low sociability behavior using NPY-knockout zebrafish	55
Fuyuan decoction prevents nasopharyngeal carcinoma metastasis by inhibiting circulating tumor cells/ endothelial cells interplay and enhancing anti-cancer immune response	55
Investigating the therapeutic potential of hesperidin targeting CRISP2 in intervertebral disc degeneration and cancer risk mitigation	55
Autophagy in renal fibrosis: Protection or promotion?	55
Traditional Chinese Medicine targeting the TGF-β/Smad signaling pathway as a potential therapeutic strategy for renal fibrosis	55
Drug-drug interactions between antithrombotics and direct-acting antivirals in hepatitis C virus (HCV) patients: A brief, updated report	55
Isoimperatorin therapeutic effect against aluminum induced neurotoxicity in albino mice	54
Inherited and acquired vitamin B12 deficiencies: Which administration route to choose for supplementation?	54
In vivo pharmacokinetics of Glycyrrhiza uralensis polysaccharides	54
The brief overview, antivirus and anti-SARS-CoV-2 activity, quantitative methods, and pharmacokinetics of cepharanthine: a potential small-molecule drug against COVID-19	54
Lycium barbarum polysaccharide reverses drug resistance in oxaliplatin-resistant colon cancer cells by inhibiting PI3K/AKT-dependent phosphomannose isomerase	54
Function-Wise Dual-Omics analysis for radiation pneumonitis prediction in lung cancer patients	54
Menisoxoisoaporphine A, a novel oxoisoaporphine alkaloid from Menispermi Rhizoma, inhibits inflammation by targeting PDE4B	54
Effects of public reporting of prescription indicators on patient choices: evidence from propensity scores matching	54
Individualized, dynamic, and full-course vancomycin dosing prediction: a study on the customized dose model	53
Editorial: Therapeutic drug monitoring (TDM): a useful tool for pediatric pharmacology applied to routine clinical practice, Volume II	53
Escitalopram oxalate-loaded chitosan nanoparticle in situ gel formulation intended for direct nose-to-brain delivery: in vitro, ex vivo, and in vivo pharmacokinetic evaluation	53
Efficacy of interventions with live combined Bacillus subtilis and Enterococcus faecium enteric-coated capsules in metabolic associated fatty liver disease patients: a meta-analysis of randomized cont	53
Protective effect and mechanism of Qingfei Paidu decoction on myocardial damage mediated by influenza viruses	53
Effects of ranolazine on the arrhythmic substrate in hypertrophic cardiomyopathy	53
Harnessing the power of natural alkaloids: the emergent role in epilepsy therapy	53
Quantum chemical calculations of nitrosamine activation and deactivation pathways for carcinogenicity risk assessment	52
Association between hyperuricemia and all-cause mortality in people taken Statins: a retrospective cohort study	52
Recent clinical evidence on nutrition, novel pharmacotherapy, and vaccination in inflammatory bowel diseases	51
D-cycloserine effects on COPD and depression in a murine experimental model	51
Modulating mitochondria with natural extract compounds: from bench to clinical therapeutic opportunities for COPD	51
Side-stepping the guardian of the genome: current cancer therapeutics targeting mutant p53	51
GraphTransNet: predicting epilepsy-related genes using a graph-augmented protein language model	51
pH-induced conformational changes in the selectivity filter of a potassium channel lead to alterations in its selectivity and permeation properties	51
Exploiting the anti-fibrotic effects of statins on thoracic aortic aneurysm progression: results from a meta-analysis and experimental data	51
Kinin B1R Activation Induces Endoplasmic Reticulum Stress in Primary Hypothalamic Neurons	50
Radiosensitization effect of iridium (III) complex on lung cancer cells via mitochondria apoptosis pathway	50
Licorice attenuates cisplatin-induced hepatotoxicity by alleviating endoplasmic reticulum stress and apoptosis	50
The electrocardiographic, hemodynamic, echocardiographic, and biochemical evaluation of treatment with edaravone on acute cardiac toxicity of aluminum phosphide	50
Myristic acid beneficially modulates intervertebral disc degeneration by preventing endplate osteochondral remodeling and vertebral osteoporosis in naturally aged mice	50
CYP2C19 variability and clinical outcomes of clopidogrel, proton pump inhibitors, and voriconazole in Southeast Asia: a systematic review and meta-analysis	50
Traditional Chinese medicine in the prevention of diabetes mellitus and cardiovascular complications: mechanisms and therapeutic approaches	50
Z1456467176 alleviates gouty arthritis by allosterically modulating P2X7R to inhibit NLRP3 inflammasome activation	49
Profile of STING agonist and inhibitor research: a bibliometric analysis	49
Real-World Evidence Study on the Long-Term Safety of Everolimus in Patients With Tuberous Sclerosis Complex: Final Analysis Results	49
Diallyl Trisulfide Enhances the Survival of Multiterritory Perforator Skin Flaps	49
Inhibition of retinal neovascularization by Dendrobium polysaccharides: a review	49
Extracellular vesicles mediate biological information delivery: A double-edged sword in cardiac remodeling after myocardial infarction	49
Evaluation of variable new antigen receptors (vNARs) as a novel cathepsin S (CTSS) targeting strategy	49
The Role of Interleukin-8 in Lung Inflammation and Injury: Implications for the Management of COVID-19 and Hyperinflammatory Acute Respiratory Distress Syndrome	49
Natural Products Modulate Cell Apoptosis: A Promising Way for the Treatment of Ulcerative Colitis	49
Effect of Combined Perftoran and Indocyanine Green-Photodynamic Therapy on HypoxamiRs and OncomiRs in Lung Cancer Cells	49
Predicting individual-specific cardiotoxicity responses induced by tyrosine kinase inhibitors	49
Transcriptome analysis revealed the genes and major pathways involved in prunetrin treated hepatocellular carcinoma cells	49
Corrigendum: The Extract of Sonneratia apetala Leaves and Branches Ameliorates Hyperuricemia in Mice by Regulating Renal Uric Acid Transporters and Suppressing the Activation of the JAK/STAT Signaling	48
Androgen receptor inhibitor ameliorates pulmonary arterial hypertension by enhancing the apoptosis level through suppressing the Notch3/Hes5 pathway	48
Fatal Tumour Lysis Syndrome Induced by Brigatinib in a Lung Adenocarcinoma Patient Treated With Sequential ALK Inhibitors: A Case Report	48
Antirheumatoid Arthritic Effects of Sabia parviflora Wall. Leaf Extracts via the NF-κB Pathway and Transient Receptor Potential Protein Family	48
Long-term administration of bumetanide improve functional recovery after spinal cord injury in rats	48
The Function of Natural Polysaccharides in the Treatment of Ulcerative Colitis	48
Differences in right ventricular function and response to targeted therapy between patients with IPAH and PAH-CHD	48
Several major herb pairs containing Coptidis rhizoma: a review of key traditional uses, constituents and compatibility effects	47
Long-Term Cardiac Damage Associated With Abdominal Irradiation in Mice	47
Cymensifin A: a promising pharmaceutical candidate to defeat lung cancer via cellular reactive oxygen species-mediated apoptosis	47
Research Progress of Chinese Herbal Medicine Intervention in Renal Interstitial Fibrosis	47
Tripterygium wilfordii glycosides ameliorates collagen-induced arthritis and aberrant lipid metabolism in rats	47
Ginsenosides, potential TMPRSS2 inhibitors, a trade-off between the therapeutic combination for anti-PD-1 immunotherapy and the treatment of COVID-19 infection of LUAD patients	47
Exploring the mechanisms and targets of proton pump inhibitors-induced osteoporosis through network toxicology, molecular docking, and molecular dynamics simulations	47
Association between HLA alleles and beta-lactam antibiotics-related severe cutaneous adverse reactions	47
Effect of herbal medicine Bojungikgi-tang on gut microbiome and symptoms in anorexic patients with atopic dermatitis: a randomized controlled trial	47
Paeonol attenuates retinopathy in streptozotocin-induced diabetes in rats by regulating the oxidative stress and polyol pathway	47
In vitro effect of hydroxychloroquine on pluripotent stem cells and their cardiomyocytes derivatives	47
Beta-blocker exposure and survival outcomes in patients with advanced pancreatic ductal adenocarcinoma: a retrospective cohort study (BETAPANC)	47
Inhibitory effects of total triterpenoids isolated from the Hedyotis diffusa willd on H1975 cells	47