OOIR: Observatory of International Research

Papers

(The H4-Index of Frontiers in Immunology is 124. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-06-01 to 2025-06-01.)

Article	Citations
Novel Allele Detection Tool Benchmark and Application With Antibody Repertoire Sequencing Dataset	736
Capturing the multifaceted function of adipose tissue macrophages	502
Dual-Organ Transcriptomic Analysis of Rainbow Trout Infected With Ichthyophthirius multifiliis Through Co-Expression and Machine Learning	398
The worthy role of hepatic arterial infusion chemotherapy in combination with anti-programmed cell death protein 1 monoclonal antibody immunotherapy in advanced hepatocellular carcinoma	362
Apoptosis in megakaryocytes: Safeguard and threat for thrombopoiesis	338
PLEKHA4 is a novel prognostic biomarker that reshapes the tumor microenvironment in lower-grade glioma	305
Fc receptors act as innate immune receptors during infection?	304
Hedgehog costimulation during ischemia-reperfusion injury potentiates cytokine and homing responses of CD4+ T cells	299
Role of nuclear receptor PXR in immune cells and inflammatory diseases	287
Perspectives of ERCC1 in early-stage and advanced cervical cancer: From experiments to clinical applications	274
Genetic deletion of HVEM in a leukemia B cell line promotes a preferential increase of PD-1- stem cell-like T cells over PD-1+ T cells curbing tumor progression	273
Editorial: Targeting key cellular signaling network for cancer chemotherapy and immunotherapy	272
Removal of natural anti-αGal antibodies elicits protective immunity against Gram-negative bacterial infections	258
Investigating the impact of STING pathway activation on breast cancer treatment outcomes: development and validation of a prognostic model	248
Salivary interleukin-17A and interferon-γ levels are elevated in children with food allergies in China	242
Editorial: The gut-immune axis: a complex training ground impacting inflammatory pathologies	236
Identification and Validation of Immune Molecular Subtypes in Pancreatic Ductal Adenocarcinoma: Implications for Prognosis and Immunotherapy	234
Profiling the T Cell Receptor Alpha/Delta Locus in Salmonids	234
The need for paradigm shift: prognostic significance and implications of standard therapy-related systemic immunosuppression in glioblastoma for immunotherapy and oncolytic virotherapy	228
Case Report: Suspected Case of Brucella-Associated Immune Reconstitution Inflammatory Syndrome	224
Whole-Process Treatment of Combined Small Cell Lung Cancer Initially Diagnosed as “Lung Squamous Cell Carcinoma”: A Case Report and Review of the Literature	224
The PRotective Effect of Maternal Immunisation on preTerm birth: characterising the Underlying mechanisms and Role in newborn immune function: the PREMITUR study protocol	219
Study protocol: a prospective single-center study for non-invasive biomonitoring of renal complications in cancer patients treated with immune checkpoint inhibitors	218
Differential in vivo labeling with barcoded antibodies allows for simultaneous transcriptomic profiling of airway, lung tissue and intravascular immune cells	215
SIRGs score may be a predictor of prognosis and immunotherapy response for esophagogastric junction adenocarcinoma	209

Case Report: Successful Treatment of Alopecia Universalis With Tofacitinib and Increased Cytokine Levels: Normal Therapeutic Reaction or Danger Signal?	207
Editorial: Novel biomarkers for predicting response to cancer immunotherapy	204
Etanercept treatment for pediatric toxic epidermal necrolysis induced by deflazacort: a case report and literature review	203
Association between circulating leukocytes and arrhythmias: Mendelian randomization analysis in immuno-cardiac electrophysiology	201
Human B-1 cells are important contributors to the naturally-occurring IgM pool against the tumor-associated ganglioside Neu5GcGM3	198
Vdelta1 T cells are more resistant than Vdelta2 T cells to the immunosuppressive properties of galectin-3	197
SRA inhibition improves antitumor potency of antigen-targeted chaperone vaccine	195
Understanding tissue-resident macrophages unlocks the potential for novel combinatorial strategies in breast cancer	192
Nomograms confirm serum IL-6 and CRP as predictors of immune checkpoint inhibitor efficacy in unresectable hepatocellular carcinoma	192
Immunological Findings and Clinical Outcomes of Infants With Positive Newborn Screening for Severe Combined Immunodeficiency From a Tertiary Care Center in the U.S.	190
Editorial: Dual role of inflammatory mediators in cancer immunotherapy	189
Serum metabolomic analysis reveals disorder of steroid hormone biosynthesis in patients with idiopathic inflammatory myopathy	188
Editorial: Characterisation, functions and roles of antigen-specific regulatory T cells in health and disease	186
The Lung Alveolar Cell (LAC) miRNome and Gene Expression Profile of the SP-A-KO Mice After Infection With and Without Rescue With Human Surfactant Protein-A2 (1A0)	184
Stereo electronic principles for selecting fully-protective, chemically-synthesised malaria vaccines	183
Editorial: Heterogeneity of ILC2s	182
Determining the Optimal (Neo)Adjuvant Regimen for Human Epidermal Growth Factor Receptor 2-Positive Breast Cancer Regarding Survival Outcome: A Network Meta-Analysis	182
Longitudinal analysis of immunocyte responses and inflammatory cytokine profiles in SFTSV-infected rhesus macaques	181
Pan-cancer analysis reveals MTTP as a prognostic and immunotherapeutic biomarker in human tumors	179
Editorial: Gasdermins in the defense against pathogens	178
Case Report: A myasthenia gravis patient complicated with renal failure was effectively treated with efgartigimod	177
The potential role of cfDNA-related innate immune responses in postoperative bone loss after alveolar bone grafting	177
Editorial: Broadening our view on nucleic acid sensing: novel sensors, signaling pathways, and involvement in non-infectious diseases	175
SARS-CoV-2 pre-exposure prophylaxis with tixagevimab/cilgavimab (AZD7442) provides protection in inborn errors of immunity with antibody defects: a real-world experience	172
Soluble Fc Receptor for IgM in Sera From Subsets of Patients With Chronic Lymphocytic Leukemia as Determined by a New Mouse Monoclonal Antibody	171
Tumor-associated CD8+T cell tolerance induced by erythroid progenitor cells	171
Experimental Models of Infectious Pulmonary Complications Following Hematopoietic Cell Transplantation	169
Long Non-Coding RNA- Associated Competing Endogenous RNA Axes in T-Cells in Multiple Sclerosis	167
A Potent and Protective Human Neutralizing Antibody Against SARS-CoV-2 Variants	167
Intracellular NAD+ Depletion Confers a Priming Signal for NLRP3 Inflammasome Activation	167
Defining a Methylation Signature Associated With Operational Tolerance in Kidney Transplant Recipients	167
Editorial: The role of toll-like receptors and their related signaling pathways in viral infection and inflammation	166
Editorial: Ubiquitin and ubiquitin-like modifications in viral infection and innate immunity	165
Tetanus-diphtheria vaccine can prime SARS-CoV-2 cross-reactive T cells	165
Vaccine Can Induce CD4-Mediated Responses to Homocitrullinated Peptides via Multiple HLA-Types and Confer Anti-Tumor Immunity	164
A novel inflammation-related lncRNAs prognostic signature identifies LINC00346 in promoting proliferation, migration, and immune infiltration of glioma	163
Editorial: Community series in the role of angiogenesis and immune response in tumor microenvironment of solid tumor, volume III	161
Knowledge, attitude, and practice of Chinese parents with infants (aged 0–3 years) toward immunity, gut microbiota and biotics: a comprehensive study	161
Neonatal overfeeding attenuates microgliosis and hippocampal damage in an infant rat model of pneumococcal meningitis	161
The roles of AIM2 in neurodegenerative diseases: insights and therapeutic implications	161
Single-cell detection of primary transcripts, their genomic loci and nuclear factors by 3D immuno-RNA/DNA FISH in T cells	161
Case Report: Real NPSLE? A patient with systemic sclerosis overlapping systemic lupus erythematosus presenting as epilepsy	160
Intratumoral high endothelial venules in solid tumors: a pooled study	158
Celiac disease - a pluripathological model in pediatric practice	158
A strategy to reconstitute immunity without GVHD via adoptive allogeneic Tscm therapy	158
Overload of the Temporomandibular Joints Accumulates γδ T Cells in a Mouse Model of Rheumatoid Arthritis: A Morphological and Histological Evaluation	158
The anti-inflammatory and tolerogenic potential of small spleen peptides	157
Editorial: Host-virus interaction at the omics and ecology levels	155
Counterproductive effects of anti-CD38 and checkpoint inhibitor for the treatment of NK/T cell lymphoma	154
Causal associations between Helicobacter Pylori infection and the risk and symptoms of Parkinson’s disease: a Mendelian randomization study	153

PD-1-siRNA Delivered by Attenuated Salmonella Enhances the Antitumor Effect of Chloroquine in Colon Cancer	152
Frequency, characteristics, and immunological accompaniments of ataxia in anti-NMDAR antibody-associated encephalitis	152
Evaluation of porcine GM-CSF during PRRSV infection in vitro and in vivo indicating a protective role of GM-CSF related with M1 biased activation in alveolar macrophage during PRRSV infection	151
Disrupted balance between pro-inflammatory lipid mediators and anti-inflammatory specialized pro-resolving mediators is linked to hyperinflammation in patients with alcoholic hepatitis	150
Respiratory syncytial virus vaccination among US adults aged ≥60 years	148
Picolinate-mediated immunomodulation: insights from Mendelian randomization on the role of NK cell percentage in the pathogenesis of lichen planus	148
Advantages of the zebrafish tumor xenograft model: the evaluation of efficacy in cancer therapy and the application to the study of lncRNAs	147
Effects of serial radon spa therapy on pain and peripheral immune status in patients suffering from musculoskeletal disorders– results from a prospective, randomized, placebo-controlled trial	145
Macrophage-derived extracellular vesicles from Ascaris lumbricoides antigen exposure enhance Mycobacterium tuberculosis growth control, reduce IL-1β, and contain miR-342-5p, miR-516b-5p, and miR-570-3	144
Elevated circulating group-2 innate lymphoid cells expressing activation markers and correlated tryptase AB1 levels in active ascariasis	144
Identification of key biomarkers related to fibrocartilage chondrocytes for osteoarthritis based on bulk, single-cell transcriptomic data	143
Integrated Transcriptome Profiling Revealed That Elevated Long Non-Coding RNA-AC007278.2 Expression Repressed CCR7 Transcription in Systemic Lupus Erythematosus	142
Divergent COVID-19 Disease Trajectories Predicted by a DAMP-Centered Immune Network Model	140
Identification of necroptosis-related subtypes, development of a novel signature, and characterization of immune infiltration in colorectal cancer	140
Influence of Combination Antiretroviral Therapy on HIV-1 Serological Responses and Their Implications: A Systematic Review and Meta-Analysis	140
CMV reactivation initiates long-term expansion and differentiation of the NK cell repertoire	139
Comparison between HIV self-testing and facility-based HIV testing approach on HIV early detection among men who have sex with men: A cross-sectional study	138
Genome-wide identification of antisense lncRNAs and their association with susceptibility to Flavobacterium psychrophilum in rainbow trout	138
Lessons from Pasteur may help prevent the deadly relapse of Ebola in patients: Using contingency vaccination to avoid Ebola relapse in immune-privileged organs	137
The histamine analogue clobenpropit modulates IRF7 phosphorylation and interferon production by targeting CXCR4 in systemic lupus erythematosus models	137
Reversal of splicing infidelity is a pre-activation step in B cell differentiation	136
Histone acetylation-related IncRNA: Potential biomarkers for predicting prognosis and immune response in lung adenocarcinoma, and distinguishing hot and cold tumours	136
Structural basis for the broad and potent cross-reactivity of an N501Y-centric antibody against sarbecoviruses	135
Predictive model for BNT162b2 vaccine response in cancer patients based on blood cytokines and growth factors	134
Influence of Type I Interferons in Gammaherpesvirus-68 and Its Influence on EAE Enhancement	134
Low Levels of Granulocytic Myeloid-Derived Suppressor Cells May Be a Good Marker of Survival in the Follow-Up of Patients With Severe COVID-19	133
Immune microenvironment changes of liver cirrhosis: emerging role of mesenchymal stromal cells	133
Good Tumor Response to Chemoradioimmunotherapy in dMMR/MSI-H Advanced Colorectal Cancer: A Case Series	133
Altered distribution and function of NK-cell subsets lead to impaired tumor surveillance in JAK2V617F myeloproliferative neoplasms	132
Proteomic and Metabolomic Characterization of SARS-CoV-2-Infected Cynomolgus Macaque at Early Stage	132
Treatment approaches for FGFR-altered urothelial carcinoma: targeted therapies and immunotherapy	132
A NK Cell Odyssey: From Bench to Therapeutics Against Hematological Malignancies	132
Neurological Infection, Kynurenine Pathway, and Parasitic Infection by Neospora caninum	131
Role of RGC-32 in multiple sclerosis and neuroinflammation – few answers and many questions	131
The Hidden Side of Complement Regulator C4BP: Dissection and Evaluation of Its Immunomodulatory Activity	130
A prognostic signature based on snoRNA predicts the overall survival of lower-grade glioma patients	129
Systemic inflammation biomarkers during angioedema attacks in hereditary angioedema	129
Lin28 regulates thymic growth and involution and correlates with MHCII expression in thymic epithelial cells	129
Exhausted signature and regulatory network of NK cells in myasthenia gravis	128
Integrative single-cell analysis of longitudinal t(8;21) AML reveals heterogeneous immune cell infiltration and prognostic signatures	128
Anti-inflammatory, antioxidant and anti-virulence roles of atractylodin in attenuating Listeria monocytogenes infection	128
AXL expression reflects tumor-immune cell dynamics impacting outcome in non-small cell lung cancer patients treated with immune checkpoint inhibitor monotherapy	127
More rapid blood interferon α2 decline in fatal versus surviving COVID-19 patients	127
High Salt Induces a Delayed Activation of Human Neutrophils	126
Early Thymectomy Is Associated With Long-Term Impairment of the Immune System: A Systematic Review	126
IL-12α deficiency attenuates pressure overload-induced cardiac inflammation, hypertrophy, dysfunction, and heart failure progression	126
Histone H2A Nuclear/Cytoplasmic Trafficking Is Essential for Negative Regulation of Antiviral Immune Response and Lysosomal Degradation of TBK1 and IRF3	125
C5a elevation in convalescents from severe COVID-19 is not associated with early complement activation markers C3bBbP or C4d	125
IL-32 is induced by activation of toll-like receptors in multiple myeloma cells	125
Chicken CH25H inhibits ALV-J replication by promoting cellular autophagy	124