Frontiers in Immunology

Papers
(The H4-Index of Frontiers in Immunology is 127. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2020-05-01 to 2024-05-01.)
ArticleCitations
Reduction and Functional Exhaustion of T Cells in Patients With Coronavirus Disease 2019 (COVID-19)1705
The COVID-19 Cytokine Storm; What We Know So Far1132
Tumor-Associated Macrophages in Tumor Immunity800
The Genus Alistipes: Gut Bacteria With Emerging Implications to Inflammation, Cancer, and Mental Health790
Cytokine Storm in COVID-19: The Current Evidence and Treatment Strategies772
Immune Response, Inflammation, and the Clinical Spectrum of COVID-19485
Cancer Stem Cells—Origins and Biomarkers: Perspectives for Targeted Personalized Therapies468
The Tumor Microenvironment: A Milieu Hindering and Obstructing Antitumor Immune Responses429
Cancer Immune Evasion Through Loss of MHC Class I Antigen Presentation421
IOBR: Multi-Omics Immuno-Oncology Biological Research to Decode Tumor Microenvironment and Signatures390
A Review of the Progress and Challenges of Developing a Vaccine for COVID-19357
Cytokine Storm in COVID-19—Immunopathological Mechanisms, Clinical Considerations, and Therapeutic Approaches: The REPROGRAM Consortium Position Paper348
The Gut-Brain Axis: How Microbiota and Host Inflammasome Influence Brain Physiology and Pathology344
Redefining Tumor-Associated Macrophage Subpopulations and Functions in the Tumor Microenvironment337
The Tumor Microenvironment in the Response to Immune Checkpoint Blockade Therapies332
Overview of Immune Response During SARS-CoV-2 Infection: Lessons From the Past330
Quercetin and Vitamin C: An Experimental, Synergistic Therapy for the Prevention and Treatment of SARS-CoV-2 Related Disease (COVID-19)329
Targeting the NLRP3 Inflammasome in Severe COVID-19323
Comparative Review of SARS-CoV-2, SARS-CoV, MERS-CoV, and Influenza A Respiratory Viruses317
Phagocytosis: Our Current Understanding of a Universal Biological Process310
Anti-Inflammatory and Immunomodulatory Effects of Probiotics in Gut Inflammation: A Door to the Body305
The SARS-CoV-2 Spike Glycoprotein Biosynthesis, Structure, Function, and Antigenicity: Implications for the Design of Spike-Based Vaccine Immunogens302
Pulmonary Innate Immune Response Determines the Outcome of Inflammation During Pneumonia and Sepsis-Associated Acute Lung Injury295
Mucosal Immunity in COVID-19: A Neglected but Critical Aspect of SARS-CoV-2 Infection291
Gut Microbiota as a Trigger for Metabolic Inflammation in Obesity and Type 2 Diabetes290
Interferon-α2b Treatment for COVID-19284
Maternal Immunological Adaptation During Normal Pregnancy277
Interplay Between NLRP3 Inflammasome and Autophagy272
Interaction of Microglia and Astrocytes in the Neurovascular Unit265
Dendritic Cells and Their Role in Immunotherapy263
The Intestinal Microbiota and Colorectal Cancer261
The Emerging Role of Neutrophil Extracellular Traps (NETs) in Tumor Progression and Metastasis249
Highlight of Immune Pathogenic Response and Hematopathologic Effect in SARS-CoV, MERS-CoV, and SARS-Cov-2 Infection246
The Biology of Lactoferrin, an Iron-Binding Protein That Can Help Defend Against Viruses and Bacteria242
Myeloid Cell-Derived Arginase in Cancer Immune Response242
The Effects of Type 2 Diabetes Mellitus on Organ Metabolism and the Immune System240
COVID-19 Coronavirus Vaccine Design Using Reverse Vaccinology and Machine Learning238
The Potential Impact of Zinc Supplementation on COVID-19 Pathogenesis236
NF-κB: At the Borders of Autoimmunity and Inflammation231
Growth/Differentiation Factor-15 (GDF-15): From Biomarker to Novel Targetable Immune Checkpoint226
Crosstalk Between Astrocytes and Microglia: An Overview223
Interleukin-6 Is a Biomarker for the Development of Fatal Severe Acute Respiratory Syndrome Coronavirus 2 Pneumonia216
Localized Interleukin-12 for Cancer Immunotherapy216
T Helper (Th) Cell Profiles in Pregnancy and Recurrent Pregnancy Losses: Th1/Th2/Th9/Th17/Th22/Tfh Cells214
Mucins in Intestinal Mucosal Defense and Inflammation: Learning From Clinical and Experimental Studies213
Reaction of Human Monoclonal Antibodies to SARS-CoV-2 Proteins With Tissue Antigens: Implications for Autoimmune Diseases213
Colorectal Cancer Immunotherapy: Options and Strategies209
SARS-CoV-2 Accessory Proteins in Viral Pathogenesis: Knowns and Unknowns204
Neutrophils in COVID-19202
Immune-Boosting, Antioxidant and Anti-inflammatory Food Supplements Targeting Pathogenesis of COVID-19199
Impact of Bacterial Metabolites on Gut Barrier Function and Host Immunity: A Focus on Bacterial Metabolism and Its Relevance for Intestinal Inflammation193
The New Era of Cancer Immunotherapy: Targeting Myeloid-Derived Suppressor Cells to Overcome Immune Evasion191
Role of Metabolic Endotoxemia in Systemic Inflammation and Potential Interventions191
Macrophages: The Good, the Bad, and the Gluttony191
Crosstalk Between the MSI Status and Tumor Microenvironment in Colorectal Cancer190
The Role of Inflammation in Diabetic Retinopathy188
Toll-Like Receptor Signaling and Its Role in Cell-Mediated Immunity188
Aspects of the Tumor Microenvironment Involved in Immune Resistance and Drug Resistance186
Macrophage Polarization and Its Role in Liver Disease185
Regulation of PD-L1 Expression by NF-κB in Cancer184
Humoral Responses and Serological Assays in SARS-CoV-2 Infections183
SARS-CoV-2 Variants, Vaccines, and Host Immunity180
Excessive Neutrophils and Neutrophil Extracellular Traps in COVID-19180
ACE2/ADAM17/TMPRSS2 Interplay May Be the Main Risk Factor for COVID-19179
The Long Road Toward COVID-19 Herd Immunity: Vaccine Platform Technologies and Mass Immunization Strategies176
CD8+ T Cell Exhaustion in Cancer173
Epstein-Barr Virus and Systemic Autoimmune Diseases170
Emerging Concepts and Technologies in Vaccine Development170
Tumor-Infiltrating Lymphocytes and Their Prognostic Value in Cutaneous Melanoma168
T Cells in Fibrosis and Fibrotic Diseases168
Severe COVID-19: NLRP3 Inflammasome Dysregulated167
Acute Transverse Myelitis (ATM):Clinical Review of 43 Patients With COVID-19-Associated ATM and 3 Post-Vaccination ATM Serious Adverse Events With the ChAdOx1 nCoV-19 Vaccine (AZD1222)164
CAR-T Cells Hit the Tumor Microenvironment: Strategies to Overcome Tumor Escape162
Role of Vascular Smooth Muscle Cell Plasticity and Interactions in Vessel Wall Inflammation161
Monocytes and Macrophages in COVID-19160
Remodeling of the Immune Response With Aging: Immunosenescence and Its Potential Impact on COVID-19 Immune Response159
B and T Cells Driving Multiple Sclerosis: Identity, Mechanisms and Potential Triggers159
Molecular Heterogeneity and Immunosuppressive Microenvironment in Glioblastoma159
Unraveling the Mystery Surrounding Post-Acute Sequelae of COVID-19157
SARS-CoV-2 Vaccines Based on the Spike Glycoprotein and Implications of New Viral Variants154
IL-1β and the Intestinal Epithelial Tight Junction Barrier152
Increased sCD163 and sCD14 Plasmatic Levels and Depletion of Peripheral Blood Pro-Inflammatory Monocytes, Myeloid and Plasmacytoid Dendritic Cells in Patients With Severe COVID-19 Pneumonia152
Identification of SARS-CoV-2 Cell Entry Inhibitors by Drug Repurposing Using in silico Structure-Based Virtual Screening Approach150
Exhausted CD8+T Cells in the Tumor Immune Microenvironment: New Pathways to Therapy150
Immunotherapy for Ovarian Cancer: Adjuvant, Combination, and Neoadjuvant149
Phage Display Derived Monoclonal Antibodies: From Bench to Bedside149
Neurotoxicity and Cytokine Release Syndrome After Chimeric Antigen Receptor T Cell Therapy: Insights Into Mechanisms and Novel Therapies148
NLRP3 Inflammasome Activation in Cancer: A Double-Edged Sword146
Role of the IL-23/IL-17 Pathway in Rheumatic Diseases: An Overview146
Efficacy, Immunogenicity and Safety of COVID-19 Vaccines: A Systematic Review and Meta-Analysis146
Reactive Oxygen Species in Macrophages: Sources and Targets145
Adjuvants for Coronavirus Vaccines145
The Chemokine Receptor CXCR4 in Cell Proliferation and Tissue Regeneration145
NF-κB Pathway as a Potential Target for Treatment of Critical Stage COVID-19 Patients144
The IL-23/IL-17 Pathway in Inflammatory Skin Diseases: From Bench to Bedside142
Anti-angiogenic Agents in Combination With Immune Checkpoint Inhibitors: A Promising Strategy for Cancer Treatment141
COVID-19: Coronavirus Vaccine Development Updates141
Immunosuppressive Mechanisms of Regulatory B Cells140
Myeloid-Derived Suppressor Cells in Tumors: From Mechanisms to Antigen Specificity and Microenvironmental Regulation140
The Global Epidemic of the SARS-CoV-2 Delta Variant, Key Spike Mutations and Immune Escape140
Immune Cells in the BBB Disruption After Acute Ischemic Stroke: Targets for Immune Therapy?139
CD38: An Immunomodulatory Molecule in Inflammation and Autoimmunity138
Different Innate and Adaptive Immune Responses to SARS-CoV-2 Infection of Asymptomatic, Mild, and Severe Cases138
Novel Coronavirus-Induced NLRP3 Inflammasome Activation: A Potential Drug Target in the Treatment of COVID-19138
Multiple Roles for Chemokines in Neutrophil Biology137
Probiotics in Medicine: A Long Debate137
Augmenting Anticancer Immunity Through Combined Targeting of Angiogenic and PD-1/PD-L1 Pathways: Challenges and Opportunities136
Genetics Insight for COVID-19 Susceptibility and Severity: A Review136
Microglia and Inflammatory Responses in Diabetic Retinopathy136
The Lung Macrophage in SARS-CoV-2 Infection: A Friend or a Foe?135
Overview: Systemic Inflammatory Response Derived From Lung Injury Caused by SARS-CoV-2 Infection Explains Severe Outcomes in COVID-19135
Omicron: A Heavily Mutated SARS-CoV-2 Variant Exhibits Stronger Binding to ACE2 and Potently Escapes Approved COVID-19 Therapeutic Antibodies135
Microbiota Modulation of the Gut-Lung Axis in COVID-19135
CXCR3 Ligands in Cancer and Autoimmunity, Chemoattraction of Effector T Cells, and Beyond134
The Roles of Inflammation in Keloid and Hypertrophic Scars134
The Oral Microbiome and Cancer134
The Immune Response and Immunopathology of COVID-19134
Partners in Leaky Gut Syndrome: Intestinal Dysbiosis and Autoimmunity133
Gamma-Delta CAR-T Cells Show CAR-Directed and Independent Activity Against Leukemia133
Cuproptosis-Related Risk Score Predicts Prognosis and Characterizes the Tumor Microenvironment in Hepatocellular Carcinoma133
Maternal-Fetal Inflammation in the Placenta and the Developmental Origins of Health and Disease133
The Role of Macrophages in Staphylococcus aureus Infection131
Contriving Multi-Epitope Subunit of Vaccine for COVID-19: Immunoinformatics Approaches131
The Role of M1/M2 Macrophage Polarization in Rheumatoid Arthritis Synovitis130
Immunosuppressive IDO in Cancer: Mechanisms of Action, Animal Models, and Targeting Strategies130
Bispecific Antibodies: From Research to Clinical Application128
Differentiation and Regulation of TH Cells: A Balancing Act for Cancer Immunotherapy128
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