OOIR: Observatory of International Research

Papers

(The H4-Index of Frontiers in Immunology is 124. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-10-01 to 2025-10-01.)

Article	Citations
Recent progress in the study of exosomes in the gastric cancer immune microenvironment	619
The transcription factor TSHZ3 promotes tumor immunosuppression and inhibits metastasis in lung adenocarcinoma	405
Systematic pan-cancer analysis identifies PKNOX1 as a potential prognostic and immunological biomarker and its functional validation	404
Novel immunochromatographic test for rapid detection of anti-factor H autoantibodies with an assessment of its clinical relevance	375
Editorial: Interaction of cell subtypes in tumor microenvironment, and implications for immunotherapy	362
Case Report: Missing zinc finger domains: hemophagocytic lymphohistiocytosis in a GATA2 deficiency patient triggered by non-tuberculous mycobacteriosis	362
Retinal response to systemic inflammation differs between sexes and neurons	346
Case Report: Decentralized trial of tolerability-adapted exercise therapy after severe Covid-19	308
Stereo electronic principles for selecting fully-protective, chemically-synthesised malaria vaccines	305
Editorial: Preclinical macaque models of viral diseases	304
A conserved motif in the immune-subdominant RAP-1 related antigen of Babesia bovis contains a B-cell epitope recognized by antibodies from protected cattle	294
IgA2 immune complexes selectively promote inflammation by human CD103+ dendritic cells	273
Public Immunity: Evolutionary Spandrels for Pathway-Amplifying Protective Antibodies	270
Cutaneous adaptive immunity and uraemia: a narrative review	259
New findings on retinal microvascular changes in patients with primary COVID-19 infection: a longitudinal study	257
Genetic Influence on Frequencies of Myeloid-Derived Cell Subpopulations in Mouse	255
Reversal of splicing infidelity is a pre-activation step in B cell differentiation	255
Interpreting high levels of unfolded Von Willebrand Factor in patients with the antiphospholipid syndrome	255
Single-Dose 13-Valent Conjugate Pneumococcal Vaccine in People Living With HIV – Immunological Response and Protection	254
Erratum: Immunoregulatory Effects of Myeloid-Derived Suppressor Cell Exosomes in Mouse Model of Autoimmune Alopecia Areata	253
Matching-adjusted indirect comparison of tislelizumab plus lenvatinib versus sintilimab plus bevacizumab biosimilar as first-line treatment for unresectable hepatocellular carcinoma	251
Editorial: Future challenges and directions in determining allo-immunity in kidney transplantation	244
Immunomodulatory and anticancer effects of moringa polyherbal infusions: potentials for preventive and therapeutic use	237
Using a Gene Network of Pyroptosis to Quantify the Responses to Immunotherapy and Prognosis for Neuroblastoma Patients	235
CyTOF reveals platelet subtype changes predicting the efficacy of combined immunotherapy and targeted therapy in liver cancer	224

Diet and Hygiene in Modulating Autoimmunity During the Pandemic Era	221
Comparative transcriptomics reveals the immune dynamics during the molting cycle of swimming crab Portunus trituberculatus	221
Alkaline sphingomyelinase (NPP7) impacts the homeostasis of intestinal T lymphocyte populations	220
Novel Allele Detection Tool Benchmark and Application With Antibody Repertoire Sequencing Dataset	218
Persistent expression of NLRP3 in spinal microglia promotes development of lumbar disc degeneration	217
Influence of Type I Interferons in Gammaherpesvirus-68 and Its Influence on EAE Enhancement	216
Identification of hub genes and their correlation with infiltration of immune cells in MYCN positive neuroblastoma based on WGCNA and LASSO algorithm	215
Polymeric Systems for Cancer Immunotherapy: A Review	213
Comprehensive Analysis of Expression, Prognostic Value, and Immune Infiltration for Ubiquitination-Related FBXOs in Pancreatic Ductal Adenocarcinoma	209
Osteopontin contributes to virus resistance associated with type I IFN expression, activation of downstream ifn-inducible effector genes, and CCR2+CD115+CD206+ macrophage infiltration following ocular	205
The potential role of cfDNA-related innate immune responses in postoperative bone loss after alveolar bone grafting	201
NKp46+ natural killer cells develop an activated/memory-like phenotype and contribute to innate immunity against experimental filarial infection	197
Characterization of immunomodulatory responses induced by manuka honey	195
Monocytic Subsets Impact Cerebral Cortex and Cognition: Differences Between Healthy Subjects and Patients With First-Episode Schizophrenia	195
Low Levels of Granulocytic Myeloid-Derived Suppressor Cells May Be a Good Marker of Survival in the Follow-Up of Patients With Severe COVID-19	194
Human B-1 cells are important contributors to the naturally-occurring IgM pool against the tumor-associated ganglioside Neu5GcGM3	193
Gelsolin Attenuates Neonatal Hyperoxia-Induced Inflammatory Responses to Rhinovirus Infection and Preserves Alveolarization	192
Predictive model for BNT162b2 vaccine response in cancer patients based on blood cytokines and growth factors	191
A novel inflammation-related lncRNAs prognostic signature identifies LINC00346 in promoting proliferation, migration, and immune infiltration of glioma	191
Paired Donor and Recipient Immunophenotyping in Allogeneic Hematopoietic Stem Cell Transplantation: A Cellular Network Approach	191
Role of B-Cell in the Pathogenesis of Systemic Sclerosis	189
Reduced T Cell and Antibody Responses to Inactivated Coronavirus Vaccine Among Individuals Above 55 Years Old	189
Case Report: Preemptive Treatment With Low-Dose PD-1 Blockade and Azacitidine for Molecular Relapsed Acute Myeloid Leukemia With RUNX1-RUNX1T1 After Allogeneic Hematopoietic Stem Cell Transplantation	187
Helicobacter pylori-infected human neutrophils exhibit impaired chemotaxis and a uropod retraction defect	186
Tolerogenic dendritic cells generated in vitro using a novel protocol mimicking mucosal tolerance mechanisms represent a potential therapeutic cell platform for induction of immune tolerance	186
Case report: A case of duodenal adenocarcinoma achieving significantly long survival treating with immune checkpoint inhibitors and chemotherapy without positive biomarkers	184
CMV reactivation initiates long-term expansion and differentiation of the NK cell repertoire	183
Characteristics of cytokines/chemokines associated with disease severity and adverse prognosis in COVID-19 patients	180
Ubiquitination in lipid metabolism reprogramming: implications for pediatric solid tumors	177
Corrigendum: Cytosolic protein translation regulates cell asymmetry and function in early TCR activation of human CD8+ T lymphocytes	177
Corrigendum: Is oxidative stress - antioxidants imbalance the physiopathogenic core in pediatric obesity?	175
The suppressive role of GLS in radiosensitivity and irradiation-induced immune response in LUAD: integrating bioinformatics and experimental insights	174
Profiling hypoxia signaling reveals a lncRNA signature contributing to immunosuppression in high-grade glioma	173
Cross-talk between cardiac lymphatics and immune cells regulates inflammatory response and cardiac recovery after myocardial infarction	172
Aberrations in peripheral B lymphocytes and B lymphocyte subsets levels in Parkinson disease: a systematic review	171
Unveiling the fungal frontier: mycological insights into inflammatory bowel disease	169
Editorial: Host-virus interaction at the omics and ecology levels	168
Differential regulation of heparan sulfate biosynthesis in fibroblasts cocultured with normal vs. cancerous prostate cells	168
Insertion of an immunodominant T helper cell epitope within the Group A Streptococcus M protein promotes an IFN-γ-dependent shift from a non-protective to a protective immune response	167
Kidney transplant outcomes in HLA desensitized patients with pretransplant CDC and/or FCM positive crossmatches	167
A conserved element in the first intron of Cd4 has a lineage specific, TCR signal-responsive, canonical enhancer function that matches the timing of cell surface CD4 upregulation required to prevent l	167
Cannabidiol and nano-selenium mediate intestinal barrier function by affecting mucosal microstructures, and gut-associated immunological and oxidative stress response in the gut of chickens infected w	164
Screening and epitope characterization of diagnostic nanobody against total and activated Bacteroides fragilis toxin	163
The role of notch signaling pathway in cancer: mechanistic insights, therapeutic potential, and clinical progress	162
Characterization of immune features and immunotherapy response in subtypes of hepatocellular carcinoma based on mitophagy	162
Case Report: Fatal cytomegalovirus pneumonia after CAR-T cell therapy in the long-term follow-up	161
Editorial: Differential Efficacy of Immune Checkpoint Inhibitors due to Age and Sex Factors	159
Association of tumor immune infiltration and prognosis with homologous recombination repair genes mutations in early triple-negative breast cancer	159
Safety of intraocular anti-VEGF antibody treatment under in vitro HTLV-1 infection	157
Editorial: Broadening our view on nucleic acid sensing: novel sensors, signaling pathways, and involvement in non-infectious diseases	154

Lessons from Pasteur may help prevent the deadly relapse of Ebola in patients: Using contingency vaccination to avoid Ebola relapse in immune-privileged organs	154
Influence of Combination Antiretroviral Therapy on HIV-1 Serological Responses and Their Implications: A Systematic Review and Meta-Analysis	154
In-Depth Immunophenotyping With Mass Cytometry During TB Treatment Reveals New T-Cell Subsets Associated With Culture Conversion	153
Differences in systemic and mucosal SARS-CoV-2 antibody prevalence in a prospective cohort of Dutch children	152
Tyrosine kinase inhibitors as potential sensitizers of adoptive T cell therapy for hepatocellular carcinoma	152
Using two-step cluster analysis to classify inpatients with primary biliary cholangitis based on autoantibodies: A real-world retrospective study of 537 patients in China	151
Development and optimization of an in-house heterologous ELISA for detection of prednisolone drug in enzyme conjugates using spacers	150
Editorial: Novel Platform for Antigen Delivery to Dendritic Cells for Immunotherapy	150
Comprehensive CRISPR-Cas9 screen identifies factors which are important for plasmablast development	149
DOCK2 and phosphoinositide-3 kinase δ mediate two complementary signaling pathways for CXCR5-dependent B cell migration	148
An mRNA-based workflow validating neo-epitope presentation through HLA-I/peptide affinity purification	147
Identification and validation of NETs-related biomarkers in active tuberculosis through bioinformatics analysis and machine learning algorithms	147
Aberrant glycosylation patterns as potential biomarkers for diagnosis and disease progression in bullous pemphigoid	146
Insight of a Metabolic Prognostic Model to Identify Tumor Environment and Drug Vulnerability for Lung Adenocarcinoma	144
Extracellular vesicles from human semen induce unique tolerogenic phenotypes in vaginal dendritic cells and regulatory T lymphocytes	144
Use of a universal targeting CAR T cell to simultaneously kill cancer cells and cancer-associated fibroblasts	143
Role of RGC-32 in multiple sclerosis and neuroinflammation – few answers and many questions	143
Successful treatment of primary refractory DLBCL/HGBL - MYC/BCL2 transformed from FL using glofitamab: a case report	142
Editorial: Understanding bladder tumor microenvironment to optimize immunotherapy	141
Editorial: Exploring cardiovascular and cerebrovascular diseases interaction with inflammation: biomarkers, drug targets, and personalized treatments through multi-omics data integration	140
sscNOVA: a semi-supervised convolutional neural network for predicting functional regulatory variants in autoimmune diseases	140
The PRotective Effect of Maternal Immunisation on preTerm birth: characterising the Underlying mechanisms and Role in newborn immune function: the PREMITUR study protocol	140
A local drug delivery system prolongs graft survival by dampening T cell infiltration and neutrophil extracellular trap formation in vascularized composite allografts	140
Utilizing noncatalytic ACE2 protein mutant as a competitive inhibitor to treat SARS-CoV-2 infection	140
Corrigendum: Material basis and molecular mechanisms of Chaihuang Qingyi Huoxue Granule in the treatment of acute pancreatitis based on network pharmacology and molecular docking-based strategy	140
Elucidating the direct effects of the novel HDAC inhibitor bocodepsin (OKI-179) on T cells to rationally design regimens for combining with immunotherapy	139
Development of high-titer class-switched antibody responses to phosphorylated amino acids is prevalent in pancreatic ductal adenocarcinoma	139
Ferroptosis, necroptosis, and pyroptosis in the occurrence and development of ovarian cancer	138
Myeloidderived suppressor cells: Escorts at the maternal–fetal interface	138
Effects of rumen cannulation combined with different pre-weaning feeding intensities on the intestinal, splenic and thymic immune system in heifer calves several month after surgery	137
Soluble Fc Receptor for IgM in Sera From Subsets of Patients With Chronic Lymphocytic Leukemia as Determined by a New Mouse Monoclonal Antibody	136
Increased monocyte abundance as a marker for relapse after discontinuation of biologics in inflammatory bowel disease with deep remission	135
Predictors of high SARS-CoV-2 immunoglobulin G titers in COVID-19 convalescent whole-blood donors: a cross-sectional study in China	135
Effectiveness and safety of dupilumab in the treatment of pediatric atopic dermatitis: a real-world study from China	135
The fungal-derived compound AM3 modulates pro-inflammatory cytokine production and skews the differentiation of human monocytes	135
NetTCR-struc, a structure driven approach for prediction of TCR-pMHC interactions	134
Transglutaminase 2 regulates ovarian cancer metastasis by modulating the immune microenvironment	133
Unveiling B7/CD28 family proteins in hepatocellular carcinoma: insights into communication and prognostic significance	133
Characterization of novel anoikis-related genes as prognostic biomarkers and key determinants of the immune microenvironment in esophageal cancer	133
Serum CRP interacts with SPARC and regulate immune response in severe cases of COVID-19 infection	131
Blinatumomab in pediatric B-acute lymphoblastic leukemia	131
Clinical and immunological features in patients with neuroimmune complications of COVID-19 during Omicron wave in China: a case series	131
Role of differentiated embryo-chondrocyte expressed gene 2 in immunity	130
Development of a pan-genotypic monoclonal antibody-based competitive ELISA for the detection of antibodies against Bovine viral diarrhea virus	130
CD39 dynamics in tuberculosis: a potential biomarker of immune dysregulation and T cell exhaustion	129
A potential strategy to rebuild the tumor immune microenvironment: PANoptosis	127
Patient-derived monoclonal antibodies to SARS-CoV-2 nucleocapsid protein N-terminal and C-terminal domains cross-react with their counterparts of SARS-CoV, but not other human betacoronaviruses	126
Tofacitinib Downregulates TNF and Poly(I:C)-Dependent MHC-II Expression in the Colonic Epithelium	126
Editorial: Nanoparticles for cancer immunotherapy: from basics to clinics	126
Regulatory T cells in spondyloarthropathies: genetic evidence, functional role, and therapeutic possibilities	124