OOIR: Observatory of International Research

Papers

(The H4-Index of Frontiers in Immunology is 124. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-08-01 to 2025-08-01.)

Article	Citations
IDO1-AhR axis increases T regulatory cells in Plasmodium vivax malaria infection	564
Comparative efficacy and safety of induction therapy in solid organ transplantation: a systematic review and network meta-analysis	426
Comprehensive analysis of phosducin-like 3 as a diagnostic, prognostic and immunological marker in pan-cancer	387
Regulation of cancer by inflammasomes: from inflammation to tumorigenesis	373
miR-107-enriched exosomes promote ROS/wnt/autophagy, inhibit intracellular mycobacterial growth and attenuate lung infection	342
Leveraging the integration of bioinformatics and machine learning to uncover common biomarkers and molecular pathways underlying diabetes and nephrolithiasis	337
Characterization of novel anoikis-related genes as prognostic biomarkers and key determinants of the immune microenvironment in esophageal cancer	319
Oncostatin M enhances the lengthening of sensory nerves and skin hypersensitivity	312
A role for DICAM+ mononuclear phagocytes in controlling neuroinflammation in multiple sclerosis	312
Modulation of the immune microenvironment using nanomaterials: a new strategy for tumor immunotherapy	287
Blinatumomab in pediatric B-acute lymphoblastic leukemia	280
Recent progress in the study of exosomes in the gastric cancer immune microenvironment	269
Transglutaminase 2 regulates ovarian cancer metastasis by modulating the immune microenvironment	268
Patrolling monocytes mediate virus neutralizing IgG effector functions: beyond neutralization capacity	244
Genetic investigation of Nordic patients with complement-mediated kidney diseases	243
Computational identification and experimental verification of a novel signature based on SARS-CoV-2–related genes for predicting prognosis, immune microenvironment and therapeutic strategies in lung a	242
Systemic inflammation biomarkers during angioedema attacks in hereditary angioedema	241
The role and therapeutic targeting of the CCL2/CCR2 signaling axis in inflammatory and fibrotic diseases	240
Predicting mitophagy-related genes and unveiling liver endothelial cell heterogeneity in hepatic ischemia-reperfusion injury	237
The HVEM-BTLA Immune Checkpoint Restrains Murine Chronic Cholestatic Liver Injury by Regulating the Gut Microbiota	234
Inhibiting SIRT-2 by AK-7 restrains airway inflammation and oxidative damage promoting lung resurgence through NF-kB and MAP kinase signaling pathway	232
Intranasal Delivery of MVA Vector Vaccine Induces Effective Pulmonary Immunity Against SARS-CoV-2 in Rodents	231
Multi-Cellular Immunological Interactions Associated With COVID-19 Infections	226
What Function Do Platelets Play in Inflammation and Bacterial and Viral Infections?	222
Development of nucleic acid-based vaccines against dengue and other mosquito-borne flaviviruses: the past, present, and future	220

Emerging Roles of Platelets in Allergic Asthma	220
An overview of viral mutagenesis and the impact on pathogenesis of SARS-CoV-2 variants	214
Advances in neutrophil extracellular traps and ferroptosis in sepsis-induced cardiomyopathy	212
The Insider: Impact of the Gut Microbiota on Cancer Immunity and Response to Therapies in Multiple Myeloma	205
The Road to Elimination: Current State of Schistosomiasis Research and Progress Towards the End Game	204
The role of tumor-associated macrophages in HPV induced cervical cancer	200
Case Report: A myasthenia gravis patient complicated with renal failure was effectively treated with efgartigimod	200
Early Thymectomy Is Associated With Long-Term Impairment of the Immune System: A Systematic Review	200
Unveiling immunogenic characteristics and neoantigens in endometrial cancer with POLE hotspot mutations for improved immunotherapy	198
Angiotensinogen and C3 compete for renin-induced complement activation	189
CD160 Promotes NK Cell Functions by Upregulating Glucose Metabolism and Negatively Correlates With HIV Disease Progression	189
Histone lysine-specific demethylase 1 regulates the proliferation of hemocytes in the oyster Crassostrea gigas	187
Integrating RNA-seq and scRNA-seq to explore the biological significance of NAD + metabolism-related genes in the initial diagnosis and relapse of childhood B-cell acute lymphoblastic leukemia	186
Eosinophils and pleural macrophages counter regulate IL-33-elicited airway inflammation via the 12/15-lipoxygenase pathway	185
Deconvolution of Adult T-Cell Leukemia/Lymphoma With Single-Cell RNA-Seq Using Frozen Archived Skin Tissue Reveals New Subset of Cancer-Associated Fibroblast	185
SIRGs score may be a predictor of prognosis and immunotherapy response for esophagogastric junction adenocarcinoma	185
Mechanism of cell death and its application in the repair of inflammatory bowel disease by mesenchymal stem cells	184
Utilizing plasma exchange for severe cytokine release syndrome after CAR-T cell therapy: clinical experience and literature insights	183
Immunoregulatory effects of Huaier (Trametes robiniophila Murr) and relevant clinical applications	183
Editorial: Immunometabolism of T cells in skin infection, autoimmunity and cancer biology	182
Preclinical studies performed in appropriate models could help identify optimal timing of combined chemotherapy and immunotherapy	181
Identification of NETs-related biomarkers and molecular clusters in systemic lupus erythematosus	180
The PRotective Effect of Maternal Immunisation on preTerm birth: characterising the Underlying mechanisms and Role in newborn immune function: the PREMITUR study protocol	179
A local drug delivery system prolongs graft survival by dampening T cell infiltration and neutrophil extracellular trap formation in vascularized composite allografts	178
Identification and validation of a dysregulated TME-related gene signature for predicting prognosis, and immunological properties in bladder cancer	177
The worthy role of hepatic arterial infusion chemotherapy in combination with anti-programmed cell death protein 1 monoclonal antibody immunotherapy in advanced hepatocellular carcinoma	176
Lrba participates in the differentiation of IgA+ B lymphocytes through TGFβR signaling	176
Immunoinformatic-driven design and evaluation of multi-epitope mRNA vaccine targeting HIV-1 gp120	175
sscNOVA: a semi-supervised convolutional neural network for predicting functional regulatory variants in autoimmune diseases	175
Protective effects of fecal microbiota transplantation against ischemic stroke and other neurological disorders: an update	174
Development of high-titer class-switched antibody responses to phosphorylated amino acids is prevalent in pancreatic ductal adenocarcinoma	173
The need for paradigm shift: prognostic significance and implications of standard therapy-related systemic immunosuppression in glioblastoma for immunotherapy and oncolytic virotherapy	172
Unraveling the role of Major Vault Protein as a novel immune-related biomarker that promotes the proliferation and migration in pancreatic adenocarcinoma	171
Elucidating the direct effects of the novel HDAC inhibitor bocodepsin (OKI-179) on T cells to rationally design regimens for combining with immunotherapy	170
Comprehensive Transcriptomic and Metabolomic Analysis of the Litopenaeus vannamei Hepatopancreas After WSSV Challenge	169
Common Variable Immunodeficiency-Associated Cancers: The Role of Clinical Phenotypes, Immunological and Genetic Factors	166
Immunometabolism – The Role of Branched-Chain Amino Acids	166
Myeloidderived suppressor cells: Escorts at the maternal–fetal interface	166
Ferroptosis, necroptosis, and pyroptosis in the occurrence and development of ovarian cancer	164
Whole-Process Treatment of Combined Small Cell Lung Cancer Initially Diagnosed as “Lung Squamous Cell Carcinoma”: A Case Report and Review of the Literature	164
Killer Cell Immunoglobulin-Like Receptor Haplotype B Modulates Susceptibility to EBV-Associated Classic Hodgkin Lymphoma	162
Effects of rumen cannulation combined with different pre-weaning feeding intensities on the intestinal, splenic and thymic immune system in heifer calves several month after surgery	160
Soluble Fc Receptor for IgM in Sera From Subsets of Patients With Chronic Lymphocytic Leukemia as Determined by a New Mouse Monoclonal Antibody	159
Predictors of high SARS-CoV-2 immunoglobulin G titers in COVID-19 convalescent whole-blood donors: a cross-sectional study in China	159
The development of CD8 T-cell exhaustion heterogeneity and the therapeutic potentials in cancer	156
Gut microbiota and pancreatic cancer risk, and the mediating role of immune cells and inflammatory cytokines: a Mendelian randomization study	155
Increased monocyte abundance as a marker for relapse after discontinuation of biologics in inflammatory bowel disease with deep remission	155
The fungal-derived compound AM3 modulates pro-inflammatory cytokine production and skews the differentiation of human monocytes	155
Synthetic 5-amino-6-D-ribitylaminouracil paired with inflammatory stimuli facilitates MAIT cell expansion in vivo	154
Etanercept treatment for pediatric toxic epidermal necrolysis induced by deflazacort: a case report and literature review	153

Clinical and immunological features in patients with neuroimmune complications of COVID-19 during Omicron wave in China: a case series	152
Serum CRP interacts with SPARC and regulate immune response in severe cases of COVID-19 infection	152
The impact of Mycobacterium tuberculosis on the macrophage cholesterol metabolism pathway	152
Pan-cancer analysis reveals MTTP as a prognostic and immunotherapeutic biomarker in human tumors	150
Development of a pan-genotypic monoclonal antibody-based competitive ELISA for the detection of antibodies against Bovine viral diarrhea virus	149
Analysis of immunogenic cell death in periodontitis based on scRNA-seq and bulk RNA-seq data	145
Role of differentiated embryo-chondrocyte expressed gene 2 in immunity	145
The transcription factor TSHZ3 promotes tumor immunosuppression and inhibits metastasis in lung adenocarcinoma	143
Pro-inflammatory macrophages suppress HIV replication in humanized mice and ex vivo co-cultures	142
Prognostic significance of early alpha fetoprotein and des-gamma carboxy prothrombin responses in unresectable hepatocellular carcinoma patients undergoing triple combination therapy	141
Infectious outcomes of a standardized subcutaneous immunoglobulin dose reduction strategy in primary immune deficiencies amid global shortage	141
Case report: A cyclic neutropenia patient with ELANE mutation accompanied by hemophagocytic lymphohistiocytosis	140
Novel immunochromatographic test for rapid detection of anti-factor H autoantibodies with an assessment of its clinical relevance	140
Systematic pan-cancer analysis identifies PKNOX1 as a potential prognostic and immunological biomarker and its functional validation	140
Sex hormones, intestinal inflammation, and the gut microbiome: Major influencers of the sexual dimorphisms in obesity	138
Multi-omics derivation of a core gene signature for predicting therapeutic response and characterizing immune dysregulation in inflammatory bowel disease	138
Editorial: Interaction of cell subtypes in tumor microenvironment, and implications for immunotherapy	138
Corrigendum: Assessing the causal relationship between genetically determined inflammatory biomarkers and low back pain risk: a bidirectional two-sample Mendelian randomization study	137
Precision-engineering of subunit vaccine particles for prevention of infectious diseases	137
A Metabolism-Related Gene Prognostic Index Bridging Metabolic Signatures and Antitumor Immune Cycling in Head and Neck Squamous Cell Carcinoma	136
Mathematical models of TCR initial triggering	136
Transcriptome analysis revealed the roles of long non-coding RNA and mRNA in the bursa of Fabricius during pigeon (Columba livia) development	136
Models of fibrolamellar carcinomas, tools for evaluation of a new era of treatments	135
m6A methylation modification and immune cell infiltration: implications for targeting the catalytic subunit m6A-METTL complex in gastrointestinal cancer immunotherapy	135
Microglial repopulation restricts ocular inflammation and choroidal neovascularization in mice	135
AXL expression reflects tumor-immune cell dynamics impacting outcome in non-small cell lung cancer patients treated with immune checkpoint inhibitor monotherapy	135
Case report: Excessive daytime sleepiness as a presenting manifestation of autoimmune glial fibrillary acidic protein astrocytopathy	135
Investigation of the efficacy and safety of wild- type and triple-gene knockout pig RBC transfusions in nonhuman primates	133
sCD28, sCD80, sCTLA-4, and sBTLA Are Promising Markers in Diagnostic and Therapeutic Approaches for Aseptic Loosening and Periprosthetic Joint Infection	133
Density-Dependent Prophylaxis in Freshwater Snails Driven by Oxylipin Chemical Cues	132
High folate receptor expression in gliomas can be detected in vivo using folate-based positron emission tomography with high tumor-to-brain uptake ratio divulging potential future targeting possibilit	132
Editorial: Ubiquitin and ubiquitin-like modifications in viral infection and innate immunity	132
IL-21 is required for the maintenance and pathogenesis of murine Vγ4+ IL-17-producing γδT cells	131
Shared genetic architecture between COVID-19 and irritable bowel syndrome: a large-scale genome-wide cross-trait analysis	131
Biological characteristics and immune responses of NK Cells in commonly used experimental mouse models	130
Circulating mucosal-like IgA responses increase with severity of Puumala orthohantavirus-caused hemorrhagic fever with renal syndrome	130
A multiscale mechanistic model of human dendritic cells for in-silico investigation of immune responses and novel therapeutics discovery	128
Genetic deletion of HVEM in a leukemia B cell line promotes a preferential increase of PD-1- stem cell-like T cells over PD-1+ T cells curbing tumor progression	128
The real life experience goes on: update after 4 years on the first cohort treated with lanadelumab at our center	128
SARS-CoV-2 strains and clinical profiles of COVID-19 patients in a Southern Brazil hospital	128
Tetanus-diphtheria vaccine can prime SARS-CoV-2 cross-reactive T cells	127
Accelerating development of engineered T cell therapies in the EU: current regulatory framework for studying multiple product versions and T2EVOLVE recommendations	127
Single-cell detection of primary transcripts, their genomic loci and nuclear factors by 3D immuno-RNA/DNA FISH in T cells	127
Investigating the impact of STING pathway activation on breast cancer treatment outcomes: development and validation of a prognostic model	126
Regionalization of intestinal microbiota and metabolites in the small intestine of the Bactrian camel	126
Correlations between the alpha-Gal antigen, antibody response and calcification of cardiac valve bioprostheses: experimental evidence obtained using an alpha-Gal knockout mouse animal model	126
Research progress of targeted therapy regulating Th17/Treg balance in bone immune diseases	124
Efficacy and safety of camrelizumab combined with albumin-bound paclitaxel as third- or later-line regimen in patients with advanced non-small cell lung cancer	124
Potential therapeutic effect of olfactory ensheathing cells in neurological diseases: neurodegenerative diseases and peripheral nerve injuries	124