OOIR: Observatory of International Research

Papers

(The H4-Index of Frontiers in Immunology is 124. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2022-01-01 to 2026-01-01.)

Article	Citations
Recent progress in the study of exosomes in the gastric cancer immune microenvironment	692
The transcription factor TSHZ3 promotes tumor immunosuppression and inhibits metastasis in lung adenocarcinoma	456
Systematic pan-cancer analysis identifies PKNOX1 as a potential prognostic and immunological biomarker and its functional validation	414
Editorial: Interaction of cell subtypes in tumor microenvironment, and implications for immunotherapy	412
Case Report: Missing zinc finger domains: hemophagocytic lymphohistiocytosis in a GATA2 deficiency patient triggered by non-tuberculous mycobacteriosis	401
Retinal response to systemic inflammation differs between sexes and neurons	383
Stereo electronic principles for selecting fully-protective, chemically-synthesised malaria vaccines	361
Editorial: Preclinical macaque models of viral diseases	338
A conserved motif in the immune-subdominant RAP-1 related antigen of Babesia bovis contains a B-cell epitope recognized by antibodies from protected cattle	337
Cutaneous adaptive immunity and uraemia: a narrative review	326
Interpreting high levels of unfolded Von Willebrand Factor in patients with the antiphospholipid syndrome	324
Editorial: Future challenges and directions in determining allo-immunity in kidney transplantation	305
Using a Gene Network of Pyroptosis to Quantify the Responses to Immunotherapy and Prognosis for Neuroblastoma Patients	303
CyTOF reveals platelet subtype changes predicting the efficacy of combined immunotherapy and targeted therapy in liver cancer	300
Diet and Hygiene in Modulating Autoimmunity During the Pandemic Era	293
Influence of Type I Interferons in Gammaherpesvirus-68 and Its Influence on EAE Enhancement	291
Identification of hub genes and their correlation with infiltration of immune cells in MYCN positive neuroblastoma based on WGCNA and LASSO algorithm	288
Comprehensive Analysis of Expression, Prognostic Value, and Immune Infiltration for Ubiquitination-Related FBXOs in Pancreatic Ductal Adenocarcinoma	283
The potential role of cfDNA-related innate immune responses in postoperative bone loss after alveolar bone grafting	280
NKp46+ natural killer cells develop an activated/memory-like phenotype and contribute to innate immunity against experimental filarial infection	278
Gelsolin Attenuates Neonatal Hyperoxia-Induced Inflammatory Responses to Rhinovirus Infection and Preserves Alveolarization	273
Predictive model for BNT162b2 vaccine response in cancer patients based on blood cytokines and growth factors	268
Paired Donor and Recipient Immunophenotyping in Allogeneic Hematopoietic Stem Cell Transplantation: A Cellular Network Approach	262
Case Report: Preemptive Treatment With Low-Dose PD-1 Blockade and Azacitidine for Molecular Relapsed Acute Myeloid Leukemia With RUNX1-RUNX1T1 After Allogeneic Hematopoietic Stem Cell Transplantation	258
Case report: A case of duodenal adenocarcinoma achieving significantly long survival treating with immune checkpoint inhibitors and chemotherapy without positive biomarkers	249

Corrigendum: Cytosolic protein translation regulates cell asymmetry and function in early TCR activation of human CD8+ T lymphocytes	247
The suppressive role of GLS in radiosensitivity and irradiation-induced immune response in LUAD: integrating bioinformatics and experimental insights	246
Corrigendum: Is oxidative stress - antioxidants imbalance the physiopathogenic core in pediatric obesity?	246
Profiling hypoxia signaling reveals a lncRNA signature contributing to immunosuppression in high-grade glioma	245
Cross-talk between cardiac lymphatics and immune cells regulates inflammatory response and cardiac recovery after myocardial infarction	238
Differential regulation of heparan sulfate biosynthesis in fibroblasts cocultured with normal vs. cancerous prostate cells	235
Editorial: Host-virus interaction at the omics and ecology levels	234
A conserved element in the first intron of Cd4 has a lineage specific, TCR signal-responsive, canonical enhancer function that matches the timing of cell surface CD4 upregulation required to prevent l	231
Kidney transplant outcomes in HLA desensitized patients with pretransplant CDC and/or FCM positive crossmatches	228
Characterization of immune features and immunotherapy response in subtypes of hepatocellular carcinoma based on mitophagy	225
Case Report: Fatal cytomegalovirus pneumonia after CAR-T cell therapy in the long-term follow-up	221
Safety of intraocular anti-VEGF antibody treatment under in vitro HTLV-1 infection	218
Editorial: Broadening our view on nucleic acid sensing: novel sensors, signaling pathways, and involvement in non-infectious diseases	215
Lessons from Pasteur may help prevent the deadly relapse of Ebola in patients: Using contingency vaccination to avoid Ebola relapse in immune-privileged organs	213
Editorial: Novel Platform for Antigen Delivery to Dendritic Cells for Immunotherapy	211
Comprehensive CRISPR-Cas9 screen identifies factors which are important for plasmablast development	209
DOCK2 and phosphoinositide-3 kinase δ mediate two complementary signaling pathways for CXCR5-dependent B cell migration	208
Aberrant glycosylation patterns as potential biomarkers for diagnosis and disease progression in bullous pemphigoid	205
Role of RGC-32 in multiple sclerosis and neuroinflammation – few answers and many questions	204
Extracellular vesicles from human semen induce unique tolerogenic phenotypes in vaginal dendritic cells and regulatory T lymphocytes	204
Editorial: Understanding bladder tumor microenvironment to optimize immunotherapy	203
Utilizing noncatalytic ACE2 protein mutant as a competitive inhibitor to treat SARS-CoV-2 infection	201
Editorial: Exploring cardiovascular and cerebrovascular diseases interaction with inflammation: biomarkers, drug targets, and personalized treatments through multi-omics data integration	198
The PRotective Effect of Maternal Immunisation on preTerm birth: characterising the Underlying mechanisms and Role in newborn immune function: the PREMITUR study protocol	196
Development of high-titer class-switched antibody responses to phosphorylated amino acids is prevalent in pancreatic ductal adenocarcinoma	194
Effects of rumen cannulation combined with different pre-weaning feeding intensities on the intestinal, splenic and thymic immune system in heifer calves several month after surgery	192
Soluble Fc Receptor for IgM in Sera From Subsets of Patients With Chronic Lymphocytic Leukemia as Determined by a New Mouse Monoclonal Antibody	191
Predictors of high SARS-CoV-2 immunoglobulin G titers in COVID-19 convalescent whole-blood donors: a cross-sectional study in China	189
The fungal-derived compound AM3 modulates pro-inflammatory cytokine production and skews the differentiation of human monocytes	188
Unveiling B7/CD28 family proteins in hepatocellular carcinoma: insights into communication and prognostic significance	184
Characterization of novel anoikis-related genes as prognostic biomarkers and key determinants of the immune microenvironment in esophageal cancer	184
Transglutaminase 2 regulates ovarian cancer metastasis by modulating the immune microenvironment	183
Editorial: Nanoparticles for cancer immunotherapy: from basics to clinics	181
Blinatumomab in pediatric B-acute lymphoblastic leukemia	181
Patient-derived monoclonal antibodies to SARS-CoV-2 nucleocapsid protein N-terminal and C-terminal domains cross-react with their counterparts of SARS-CoV, but not other human betacoronaviruses	180
Corrigendum: Assessing the causal relationship between genetically determined inflammatory biomarkers and low back pain risk: a bidirectional two-sample Mendelian randomization study	177
Transcriptome analysis revealed the roles of long non-coding RNA and mRNA in the bursa of Fabricius during pigeon (Columba livia) development	176
Models of fibrolamellar carcinomas, tools for evaluation of a new era of treatments	173
SARS-CoV-2 strains and clinical profiles of COVID-19 patients in a Southern Brazil hospital	169
Genetic deletion of HVEM in a leukemia B cell line promotes a preferential increase of PD-1- stem cell-like T cells over PD-1+ T cells curbing tumor progression	168
Investigating the impact of STING pathway activation on breast cancer treatment outcomes: development and validation of a prognostic model	167
Efficacy and safety of camrelizumab combined with albumin-bound paclitaxel as third- or later-line regimen in patients with advanced non-small cell lung cancer	165
The XIAP inhibitor AZD5582 improves the treatment effect of microwave ablation on hepatocellular carcinoma	164
Case Report: Real NPSLE? A patient with systemic sclerosis overlapping systemic lupus erythematosus presenting as epilepsy	162
Corrigendum: Structural informatics approach for designing an epitope-based vaccine against the brain-eating Naegleria fowleri	157
Editorial: Targeting key cellular signaling network for cancer chemotherapy and immunotherapy	156
Neonatal overfeeding attenuates microgliosis and hippocampal damage in an infant rat model of pneumococcal meningitis	155
Editorial: Gasdermins in the defense against pathogens	154
More rapid blood interferon α2 decline in fatal versus surviving COVID-19 patients	154
Cardiovascular impairment in Shiga-toxin-2-induced experimental hemolytic–uremic syndrome: a pilot study	154

Editorial: Novel biomarkers for predicting response to cancer immunotherapy	153
Dynamics of IgG antibody response against Plasmodium antigens among Nigerian infants and young children	153
Case report: A family of atypical hemolytic uremic syndrome involving a CFH::CFHR1 fusion gene and CFHR3-1-4-2 gene duplication	152
Lin28 regulates thymic growth and involution and correlates with MHCII expression in thymic epithelial cells	152
Editorial: Molecular and cellular control of B cell responses: germinal center and extrafollicular responses for cellular outputs	151
Case report: Successful remission with upadacitinib in a young patient with anti-TNF-refractory intestinal Behçet’s disease	151
Alpha-defensins increase NTHi binding but not engulfment by the macrophages enhancing airway inflammation in Alpha-1 antitrypsin deficiency	151
Editorial: The role of toll-like receptors and their related signaling pathways in viral infection and inflammation	151
Picolinate-mediated immunomodulation: insights from Mendelian randomization on the role of NK cell percentage in the pathogenesis of lichen planus	150
Identification and functional characterization of T-cell exhaustion-associated lncRNA AL031775.1 in osteosarcoma: a novel therapeutic target	147
TNFRSF12A expression in stomach adenocarcinoma and its preliminary role in predicting immunotherapy response	146
Immune mediators as plasma biomarkers for identifying household contacts and classifying clinical forms and leprosy reactions	146
Retraction: MicroRNA-200a inhibits inflammation and atherosclerotic lesion formation by disrupting EZH2-mediated methylation of STAT3	145
Corrigendum: A clash on the Toll pathway: competitive action between pesticides and zymosan A on components of innate immunity in Apis mellifera	144
Proteomics profiling reveals lipid metabolism abnormalities during oogenesis in unexplained recurrent pregnancy loss	143
CHI3L1 in the CSF is a potential biomarker for anti-leucine-rich glioma inactivated 1 encephalitis	143
Exhausted signature and regulatory network of NK cells in myasthenia gravis	143
Intratumoral high endothelial venules in solid tumors: a pooled study	142
Editorial: Crosstalk between cell death, oxidative stress, and immune regulation	141
SRA inhibition improves antitumor potency of antigen-targeted chaperone vaccine	140
Editorial: Liver transplantation for liver cancer in the era of transplant oncology: accurate diagnosis and treatment	139
Sphingosylphosphorylcholine inhibits plasma cell differentiation and ameliorates experimental autoimmune encephalomyelitis	139
Removal of natural anti-αGal antibodies elicits protective immunity against Gram-negative bacterial infections	139
Editorial: Balanced and Unbalanced Immune Response to Dengue Virus in Disease Protection and Pathogenesis	139
The impact of cytoreductive nephrectomy on survival outcomes in patients with metastatic renal cell carcinoma receiving immunotherapy: An evidence-based analysis of comparative outcomes	138
Editorial: Immunoglobulin Glycosylation Analysis: State-of-the-Art Methods and Applications in Immunology	138
Integrated bioinformatics analysis identifies shared immune changes between ischemic stroke and COVID 19	137
Corrigendum: Potential gut microbiota features for non-invasive detection of schistosomiasis	136
Unraveling the immunological landscape in acute pancreatitis progression to sepsis: insights from a Mendelian randomization study on immune cell traits	136
A specific immune signature for predicting the prognosis of glioma patients with IDH1-mutation and guiding immune checkpoint blockade therapy	136
Prognostic models for predicting postoperative recurrence in Crohn’s disease: a systematic review and critical appraisal	135
Differential in vivo labeling with barcoded antibodies allows for simultaneous transcriptomic profiling of airway, lung tissue and intravascular immune cells	135
Identification of necroptosis-related subtypes, development of a novel signature, and characterization of immune infiltration in colorectal cancer	134
S1PR-1/5 modulator RP-101074 shows beneficial effects in a model of central nervous system degeneration	134
Salivary interleukin-17A and interferon-γ levels are elevated in children with food allergies in China	134
Study protocol: a prospective single-center study for non-invasive biomonitoring of renal complications in cancer patients treated with immune checkpoint inhibitors	133
IL-32 is induced by activation of toll-like receptors in multiple myeloma cells	133
Nanomaterial assisted natural killer cell therapy	132
Determining the Optimal (Neo)Adjuvant Regimen for Human Epidermal Growth Factor Receptor 2-Positive Breast Cancer Regarding Survival Outcome: A Network Meta-Analysis	132
Counterproductive effects of anti-CD38 and checkpoint inhibitor for the treatment of NK/T cell lymphoma	132
The HVEM-BTLA Immune Checkpoint Restrains Murine Chronic Cholestatic Liver Injury by Regulating the Gut Microbiota	131
Case Report: A myasthenia gravis patient complicated with renal failure was effectively treated with efgartigimod	131
Patrolling monocytes mediate virus neutralizing IgG effector functions: beyond neutralization capacity	131
Unveiling immunogenic characteristics and neoantigens in endometrial cancer with POLE hotspot mutations for improved immunotherapy	129
SIRGs score may be a predictor of prognosis and immunotherapy response for esophagogastric junction adenocarcinoma	128
Induction chemoradiotherapy achieves long-term recurrence-free survival in locally advanced pulmonary lymphoepithelioma-like carcinoma: a case report and literature review	127
Serum adipsin levels in rheumatic diseases: defining its role in disease activity and progression in rheumatoid arthritis and axial spondyloarthritis	125
Correlation between SARS-CoV-2-specific antibody titers and the hormones DHEA, cortisol, testosterone, and progesterone	125
Perspectives of ERCC1 in early-stage and advanced cervical cancer: From experiments to clinical applications	125
The first successful bone marrow transplantation in Vietnam for a young Vietnamese boy with chronic granulomatous disease: a case report	124