OOIR: Observatory of International Research

Papers

(The H4-Index of Acta Pharmacologica Sinica is 45. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-11-01 to 2025-11-01.)

Article	Citations
Single-dose methamphetamine administration impairs ORM retrieval in mice via excessive DA-mediated inhibition of PrLGlu activity	298
Author Correction: Discovery of toxoflavin, a potent IRE1α inhibitor acting through structure-dependent oxidative inhibition	196
S670, an amide derivative of 3-O-acetyl-11-keto-β-boswellic acid, induces ferroptosis in human glioblastoma cells by generating ROS and inhibiting STX17-mediated fusion of autophagosome and lysosome	147
ADT-OH inhibits malignant melanoma metastasis in mice via suppressing CSE/CBS and FAK/Paxillin signaling pathway	127
Aspirin triggers ferroptosis in hepatocellular carcinoma cells through restricting NF-κB p65-activated SLC7A11 transcription	113
Extracellular vesicles in vascular remodeling	113
Targeted degradation of membrane and extracellular proteins with LYTACs	108
Reducing lipid peroxidation attenuates stress-induced susceptibility to herpes simplex virus type 1	101
tRF3-IleAAT reduced extracellular matrix synthesis in diabetic kidney disease mice by targeting ZNF281 and inhibiting ferroptosis	98
Integration of machine learning and experimental validation reveals new lipid-lowering drug candidates	93
Identification of Licoflavone C as a cap-dependent endonuclease inhibitor against severe fever with thrombocytopenia syndrome virus	92
Celastrol suppresses the growth of vestibular schwannoma in mice by promoting the degradation of β-catenin	92
Translin deletion impairs cocaine-induced locomotor sensitization and RGS8 expression in the nucleus accumbens	86
GRK2-mediated phosphorylation and de-succinylation of PKM2 reduce macrophage glycolysis in rheumatoid arthritis	84
Compound 38, a novel potent and selective antagonist of adenosine A2A receptor, enhances arousal in mice	82
Cystathionine γ-lyase-derived H2S negatively regulates thymic egress via allosteric inhibition of sphingosine-1-phosphate lyase	81
Iguratimod suppresses plasma cell differentiation and ameliorates experimental Sjögren’s syndrome in mice by promoting TEC kinase degradation	79
Natural product-based screening led to the discovery of a novel PXR agonist with anti-cholestasis activity	75
Ginsenoside Rg1 ameliorates stress-exacerbated Parkinson’s disease in mice by eliminating RTP801 and α-synuclein autophagic degradation obstacle	71
Channelopathy of small- and intermediate-conductance Ca2+-activated K+ channels	71
MC1R and melanin-based molecular probes for theranostic of melanoma and beyond	69
Zonisamide attenuates pressure overload-induced myocardial hypertrophy in mice through proteasome inhibition	67
Satellite cell-derived exosome-mediated delivery of microRNA-23a/27a/26a cluster ameliorates the renal tubulointerstitial fibrosis in mouse diabetic nephropathy	66
Activating Wnt/β-catenin signaling by autophagic degradation of APC contributes to the osteoblast differentiation effect of soy isoflavone on osteoporotic mesenchymal stem cells	64
Pyroptosis and pyroptosis-inducing cancer drugs	63

The hybrid oncolytic peptide NTP-385 potently inhibits adherent cancer cells by targeting the nucleus	62
Dual-responsive nanoparticles loading bevacizumab and gefitinib for molecular targeted therapy against non-small cell lung cancer	60
Otilonium bromide ameliorates pulmonary fibrosis in mice through activating phosphatase PPM1A	60
Transport mechanism and drug discovery of human monocarboxylate transporter 1	59
Dendritic cell-liposome conjugates reverse immunosuppressive tumor microenvironment for inhibiting colitis-associated colorectal cancer	57
Author Correction: ADH1C inhibits progression of colorectal cancer through the ADH1C/PHGDH /PSAT1/serine metabolic pathway	56
Correction to: EPHA2 feedback activation limits the response to PDEδ inhibition in KRAS-dependent cancer cells	56
143D, a novel selective KRASG12C inhibitor exhibits potent antitumor activity in preclinical models	55
TRADD-mediated pyroptosis contributes to diabetic cardiomyopathy	55
p52-ZER6: a determinant of tumor cell sensitivity to MDM2-p53 binding inhibitors	55
Exploring the distinct activation mechanisms of neuromedin B receptor through multiple replica molecular dynamics simulations and Markov state modeling	55
Mitochondrial calcium uniporter promotes kidney aging in mice through inducing mitochondrial calcium-mediated renal tubular cell senescence	54
Retraction Note: Physcion inhibits the metastatic potential of human colorectal cancer SW620 cells in vitro by suppressing the transcription factor SOX2	52
Insomnia-related rodent models in drug discovery	51
Gastrodin promotes CNS myelinogenesis and alleviates demyelinating injury by activating the PI3K/AKT/mTOR signaling	51
Antagonism of histamine H3 receptor promotes angiogenesis following focal cerebral ischemia	48
Transcriptional regulation and small compound targeting of ACE2 in lung epithelial cells	47
Thoracic perivascular adipose tissue inhibits VSMC apoptosis and aortic aneurysm formation in mice via the secretome of browning adipocytes	46
Structure basis for inhibition of SARS-CoV-2 by the feline drug GC376	46
Sortilin deletion in the prefrontal cortex and hippocampus ameliorates depressive-like behaviors in mice via regulating ASM/ceramide signaling	45