OOIR: Observatory of International Research

Papers

(The H4-Index of Acta Pharmacologica Sinica is 48. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2022-06-01 to 2026-06-01.)

Article	Citations
Translin deletion impairs cocaine-induced locomotor sensitization and RGS8 expression in the nucleus accumbens	361
Otilonium bromide ameliorates pulmonary fibrosis in mice through activating phosphatase PPM1A	200
Cystathionine γ-lyase-derived H2S negatively regulates thymic egress via allosteric inhibition of sphingosine-1-phosphate lyase	180
Compound 38, a novel potent and selective antagonist of adenosine A2A receptor, enhances arousal in mice	160
The hybrid oncolytic peptide NTP-385 potently inhibits adherent cancer cells by targeting the nucleus	114
Reducing lipid peroxidation attenuates stress-induced susceptibility to herpes simplex virus type 1	114
MC1R and melanin-based molecular probes for theranostic of melanoma and beyond	111
Author Correction: Discovery of toxoflavin, a potent IRE1α inhibitor acting through structure-dependent oxidative inhibition	108
Single-dose methamphetamine administration impairs ORM retrieval in mice via excessive DA-mediated inhibition of PrLGlu activity	102
Zonisamide attenuates pressure overload-induced myocardial hypertrophy in mice through proteasome inhibition	101
Identification of Licoflavone C as a cap-dependent endonuclease inhibitor against severe fever with thrombocytopenia syndrome virus	97
Satellite cell-derived exosome-mediated delivery of microRNA-23a/27a/26a cluster ameliorates the renal tubulointerstitial fibrosis in mouse diabetic nephropathy	95
Activating Wnt/β-catenin signaling by autophagic degradation of APC contributes to the osteoblast differentiation effect of soy isoflavone on osteoporotic mesenchymal stem cells	80
S670, an amide derivative of 3-O-acetyl-11-keto-β-boswellic acid, induces ferroptosis in human glioblastoma cells by generating ROS and inhibiting STX17-mediated fusion of autophagosome and lysosome	80
Iguratimod suppresses plasma cell differentiation and ameliorates experimental Sjögren’s syndrome in mice by promoting TEC kinase degradation	79
GRK2-mediated phosphorylation and de-succinylation of PKM2 reduce macrophage glycolysis in rheumatoid arthritis	78
Integration of machine learning and experimental validation reveals new lipid-lowering drug candidates	78
ER-phagy receptors: structural mechanisms in selective ER degradation and disease implications	77
Magnolin overcomes EGFR TKI resistance in NSCLC by modulation of NDRG1-NRG2-HECW1 pathway	77
CSF1R inhibitor C19 for glioma immunotherapy enabled by brain-targeting liposomal delivery	76
Ginsenoside Rg1 ameliorates stress-exacerbated Parkinson’s disease in mice by eliminating RTP801 and α-synuclein autophagic degradation obstacle	76
Targeted degradation of membrane and extracellular proteins with LYTACs	75
Aspirin triggers ferroptosis in hepatocellular carcinoma cells through restricting NF-κB p65-activated SLC7A11 transcription	74
tRF3-IleAAT reduced extracellular matrix synthesis in diabetic kidney disease mice by targeting ZNF281 and inhibiting ferroptosis	70
Resibufogenin ameliorates cerebral ischemia-reperfusion injury by modulating microglial redox homeostasis via Keap1-Nrf2-TFR1/ARE axis	69

Channelopathy of small- and intermediate-conductance Ca2+-activated K+ channels	69
Discovery and pharmacological characterization of 1,2,3,4-tetrahydroquinoline derivatives as RORγ inverse agonists against prostate cancer	69
143D, a novel selective KRASG12C inhibitor exhibits potent antitumor activity in preclinical models	68
Insomnia-related rodent models in drug discovery	67
Trametinib, an anti-tumor drug, promotes oligodendrocytes generation and myelin formation	66
Exploring the distinct activation mechanisms of neuromedin B receptor through multiple replica molecular dynamics simulations and Markov state modeling	65
Hernandezine induces autophagic cell death in human pancreatic cancer cells via activation of the ROS/AMPK signaling pathway	62
Structure basis for inhibition of SARS-CoV-2 by the feline drug GC376	62
Dual-responsive nanoparticles loading bevacizumab and gefitinib for molecular targeted therapy against non-small cell lung cancer	61
Liver X receptor inverse agonist SR9243 attenuates rheumatoid arthritis via modulating glycolytic metabolism of macrophages	60
Dendritic cell-liposome conjugates reverse immunosuppressive tumor microenvironment for inhibiting colitis-associated colorectal cancer	59
Mitochondrial calcium uniporter promotes kidney aging in mice through inducing mitochondrial calcium-mediated renal tubular cell senescence	59
Cell-based cancer immunotherapy: milestones, mechanistic insights, and emerging therapeutic directions	57
p52-ZER6: a determinant of tumor cell sensitivity to MDM2-p53 binding inhibitors	55
Transport mechanism and drug discovery of human monocarboxylate transporter 1	52
TRADD-mediated pyroptosis contributes to diabetic cardiomyopathy	51
LN-439A, a novel BAP1 inhibitor, suppresses the growth of basal-like breast cancer by degrading KLF5	50
Correction to: EPHA2 feedback activation limits the response to PDEδ inhibition in KRAS-dependent cancer cells	50
Retraction Note: Physcion inhibits the metastatic potential of human colorectal cancer SW620 cells in vitro by suppressing the transcription factor SOX2	50
Author Correction: ADH1C inhibits progression of colorectal cancer through the ADH1C/PHGDH /PSAT1/serine metabolic pathway	50
DNMT inhibition epigenetically restores the cGAS-STING pathway and activates RIG-I/MDA5-MAVS to enhance antitumor immunity	49
Gastrodin promotes CNS myelinogenesis and alleviates demyelinating injury by activating the PI3K/AKT/mTOR signaling	49
Thoracic perivascular adipose tissue inhibits VSMC apoptosis and aortic aneurysm formation in mice via the secretome of browning adipocytes	49
Contrastive learning-based drug screening model for GluN1/GluN3A inhibitors	48
AlphaFold3 versus experimental structures: assessment of the accuracy in ligand-bound G protein-coupled receptors	48
Fangchinoline-mediated autophagy inhibition amplifies antigen presentation and PD-1 blockade efficacy in lung cancer	48