OOIR: Observatory of International Research

Papers

(The H4-Index of Acta Pharmacologica Sinica is 50. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2022-08-01 to 2026-08-01.)

Article	Citations
Compound 38, a novel potent and selective antagonist of adenosine A2A receptor, enhances arousal in mice	385
Author Correction: Discovery of toxoflavin, a potent IRE1α inhibitor acting through structure-dependent oxidative inhibition	213
Single-dose methamphetamine administration impairs ORM retrieval in mice via excessive DA-mediated inhibition of PrLGlu activity	188
Identification of Licoflavone C as a cap-dependent endonuclease inhibitor against severe fever with thrombocytopenia syndrome virus	170
Iguratimod suppresses plasma cell differentiation and ameliorates experimental Sjögren’s syndrome in mice by promoting TEC kinase degradation	119
Magnolin overcomes EGFR TKI resistance in NSCLC by modulation of NDRG1-NRG2-HECW1 pathway	119
Translin deletion impairs cocaine-induced locomotor sensitization and RGS8 expression in the nucleus accumbens	118
CSF1R inhibitor C19 for glioma immunotherapy enabled by brain-targeting liposomal delivery	113
Zonisamide attenuates pressure overload-induced myocardial hypertrophy in mice through proteasome inhibition	107
Activating Wnt/β-catenin signaling by autophagic degradation of APC contributes to the osteoblast differentiation effect of soy isoflavone on osteoporotic mesenchymal stem cells	105
Molecular mechanisms for sustaining cancer stem cells characteristics and targeted therapeutic strategies	103
ER-phagy receptors: structural mechanisms in selective ER degradation and disease implications	90
Cystathionine γ-lyase-derived H2S negatively regulates thymic egress via allosteric inhibition of sphingosine-1-phosphate lyase	90
Satellite cell-derived exosome-mediated delivery of microRNA-23a/27a/26a cluster ameliorates the renal tubulointerstitial fibrosis in mouse diabetic nephropathy	89
Otilonium bromide ameliorates pulmonary fibrosis in mice through activating phosphatase PPM1A	87
Targeted degradation of membrane and extracellular proteins with LYTACs	86
Integration of machine learning and experimental validation reveals new lipid-lowering drug candidates	86
MC1R and melanin-based molecular probes for theranostic of melanoma and beyond	85
Reducing lipid peroxidation attenuates stress-induced susceptibility to herpes simplex virus type 1	85
S670, an amide derivative of 3-O-acetyl-11-keto-β-boswellic acid, induces ferroptosis in human glioblastoma cells by generating ROS and inhibiting STX17-mediated fusion of autophagosome and lysosome	83
tRF3-IleAAT reduced extracellular matrix synthesis in diabetic kidney disease mice by targeting ZNF281 and inhibiting ferroptosis	81
Aspirin triggers ferroptosis in hepatocellular carcinoma cells through restricting NF-κB p65-activated SLC7A11 transcription	78
Ginsenoside Rg1 ameliorates stress-exacerbated Parkinson’s disease in mice by eliminating RTP801 and α-synuclein autophagic degradation obstacle	77
GRK2-mediated phosphorylation and de-succinylation of PKM2 reduce macrophage glycolysis in rheumatoid arthritis	77
Resibufogenin ameliorates cerebral ischemia-reperfusion injury by modulating microglial redox homeostasis via Keap1-Nrf2-TFR1/ARE axis	76

Discovery and pharmacological characterization of 1,2,3,4-tetrahydroquinoline derivatives as RORγ inverse agonists against prostate cancer	74
143D, a novel selective KRASG12C inhibitor exhibits potent antitumor activity in preclinical models	73
Insomnia-related rodent models in drug discovery	73
Trametinib, an anti-tumor drug, promotes oligodendrocytes generation and myelin formation	69
Cell-based cancer immunotherapy: milestones, mechanistic insights, and emerging therapeutic directions	68
Correction to: EPHA2 feedback activation limits the response to PDEδ inhibition in KRAS-dependent cancer cells	65
Author Correction: ADH1C inhibits progression of colorectal cancer through the ADH1C/PHGDH /PSAT1/serine metabolic pathway	65
Retraction Note: Physcion inhibits the metastatic potential of human colorectal cancer SW620 cells in vitro by suppressing the transcription factor SOX2	63
Exploring the distinct activation mechanisms of neuromedin B receptor through multiple replica molecular dynamics simulations and Markov state modeling	62
Gastrodin promotes CNS myelinogenesis and alleviates demyelinating injury by activating the PI3K/AKT/mTOR signaling	59
DNMT1-mediated central amygdala to locus coeruleus circuit contributes to chronic pain-related depression in mice	56
Mitochondrial calcium uniporter promotes kidney aging in mice through inducing mitochondrial calcium-mediated renal tubular cell senescence	56
ATF3/SOX11-regulated FST activates IGF1R–ERK/AKT–Sp1 signaling to sustain trigeminal neuropathic pain	56
Liver X receptor inverse agonist SR9243 attenuates rheumatoid arthritis via modulating glycolytic metabolism of macrophages	55
Thoracic perivascular adipose tissue inhibits VSMC apoptosis and aortic aneurysm formation in mice via the secretome of browning adipocytes	55
p52-ZER6: a determinant of tumor cell sensitivity to MDM2-p53 binding inhibitors	54
TRADD-mediated pyroptosis contributes to diabetic cardiomyopathy	54
Transport mechanism and drug discovery of human monocarboxylate transporter 1	52
LN-439A, a novel BAP1 inhibitor, suppresses the growth of basal-like breast cancer by degrading KLF5	52
Hernandezine induces autophagic cell death in human pancreatic cancer cells via activation of the ROS/AMPK signaling pathway	52
Dendritic cell-liposome conjugates reverse immunosuppressive tumor microenvironment for inhibiting colitis-associated colorectal cancer	52
GATA3 drives chronic stress-induced depressive-like behaviors by reducing hippocampal CA3 pyramidal neuronal activity in male mice	51
Methionine-choline deficient diet deteriorates DSS-induced murine colitis through disturbance of gut microbes and infiltration of macrophages	51
DNMT inhibition epigenetically restores the cGAS-STING pathway and activates RIG-I/MDA5-MAVS to enhance antitumor immunity	51
SGLT2 inhibitor empagliflozin promotes revascularization in diabetic mouse hindlimb ischemia by inhibiting ferroptosis	51
Dendritic cell diversity and dysfunction in cancer: implications for immunotherapy and therapeutic targeting	50