OOIR: Observatory of International Research

Papers

(The H4-Index of Acta Pharmacologica Sinica is 45. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-06-01 to 2025-06-01.)

Article	Citations
Iguratimod suppresses plasma cell differentiation and ameliorates experimental Sjögren’s syndrome in mice by promoting TEC kinase degradation	243
Author Correction: Discovery of toxoflavin, a potent IRE1α inhibitor acting through structure-dependent oxidative inhibition	149
Celastrol suppresses the growth of vestibular schwannoma in mice by promoting the degradation of β-catenin	130
Single-dose methamphetamine administration impairs ORM retrieval in mice via excessive DA-mediated inhibition of PrLGlu activity	126
Identification of Licoflavone C as a cap-dependent endonuclease inhibitor against severe fever with thrombocytopenia syndrome virus	108
Otilonium bromide ameliorates pulmonary fibrosis in mice through activating phosphatase PPM1A	99
Integration of machine learning and experimental validation reveals new lipid-lowering drug candidates	97
Compound 38, a novel potent and selective antagonist of adenosine A2A receptor, enhances arousal in mice	89
MC1R and melanin-based molecular probes for theranostic of melanoma and beyond	87
Paris saponin VII, a Hippo pathway activator, induces autophagy and exhibits therapeutic potential against human breast cancer cells	86
Reducing lipid peroxidation attenuates stress-induced susceptibility to herpes simplex virus type 1	86
Translin deletion impairs cocaine-induced locomotor sensitization and RGS8 expression in the nucleus accumbens	86
Channelopathy of small- and intermediate-conductance Ca2+-activated K+ channels	81
Aspirin triggers ferroptosis in hepatocellular carcinoma cells through restricting NF-κB p65-activated SLC7A11 transcription	79
Ginsenoside Rg1 ameliorates stress-exacerbated Parkinson’s disease in mice by eliminating RTP801 and α-synuclein autophagic degradation obstacle	78
Extracellular vesicles in vascular remodeling	75
Cystathionine γ-lyase-derived H2S negatively regulates thymic egress via allosteric inhibition of sphingosine-1-phosphate lyase	75
S670, an amide derivative of 3-O-acetyl-11-keto-β-boswellic acid, induces ferroptosis in human glioblastoma cells by generating ROS and inhibiting STX17-mediated fusion of autophagosome and lysosome	75
ADT-OH inhibits malignant melanoma metastasis in mice via suppressing CSE/CBS and FAK/Paxillin signaling pathway	69
Pyroptosis and pyroptosis-inducing cancer drugs	65
The hybrid oncolytic peptide NTP-385 potently inhibits adherent cancer cells by targeting the nucleus	63
Natural product-based screening led to the discovery of a novel PXR agonist with anti-cholestasis activity	61
Activating Wnt/β-catenin signaling by autophagic degradation of APC contributes to the osteoblast differentiation effect of soy isoflavone on osteoporotic mesenchymal stem cells	60
Satellite cell-derived exosome-mediated delivery of microRNA-23a/27a/26a cluster ameliorates the renal tubulointerstitial fibrosis in mouse diabetic nephropathy	60
Zonisamide attenuates pressure overload-induced myocardial hypertrophy in mice through proteasome inhibition	59

GRK2-mediated phosphorylation and de-succinylation of PKM2 reduce macrophage glycolysis in rheumatoid arthritis	57
Role of TRPM2 in brain tumours and potential as a drug target	56
Targeted degradation of membrane and extracellular proteins with LYTACs	56
tRF3-IleAAT reduced extracellular matrix synthesis in diabetic kidney disease mice by targeting ZNF281 and inhibiting ferroptosis	54
Antagonism of histamine H3 receptor promotes angiogenesis following focal cerebral ischemia	53
Transport mechanism and drug discovery of human monocarboxylate transporter 1	53
Transcriptional regulation and small compound targeting of ACE2 in lung epithelial cells	53
Author Correction: ADH1C inhibits progression of colorectal cancer through the ADH1C/PHGDH /PSAT1/serine metabolic pathway	52
Liver X receptor inverse agonist SR9243 attenuates rheumatoid arthritis via modulating glycolytic metabolism of macrophages	52
Sortilin deletion in the prefrontal cortex and hippocampus ameliorates depressive-like behaviors in mice via regulating ASM/ceramide signaling	51
Discovery and pharmacological characterization of 1,2,3,4-tetrahydroquinoline derivatives as RORγ inverse agonists against prostate cancer	51
p52-ZER6: a determinant of tumor cell sensitivity to MDM2-p53 binding inhibitors	50
143D, a novel selective KRASG12C inhibitor exhibits potent antitumor activity in preclinical models	49
Identification of pimavanserin tartrate as a potent Ca2+-calcineurin-NFAT pathway inhibitor for glioblastoma therapy	48
Insomnia-related rodent models in drug discovery	48
Correction to: EPHA2 feedback activation limits the response to PDEδ inhibition in KRAS-dependent cancer cells	47
TRADD-mediated pyroptosis contributes to diabetic cardiomyopathy	47
Trametinib, an anti-tumor drug, promotes oligodendrocytes generation and myelin formation	47
Benzimidazoles induce concurrent apoptosis and pyroptosis of human glioblastoma cells via arresting cell cycle	46
LN-439A, a novel BAP1 inhibitor, suppresses the growth of basal-like breast cancer by degrading KLF5	46