OOIR: Observatory of International Research

Papers

(The H4-Index of Acta Pharmacologica Sinica is 45. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2022-01-01 to 2026-01-01.)

Article	Citations
Author Correction: Discovery of toxoflavin, a potent IRE1α inhibitor acting through structure-dependent oxidative inhibition	310
Satellite cell-derived exosome-mediated delivery of microRNA-23a/27a/26a cluster ameliorates the renal tubulointerstitial fibrosis in mouse diabetic nephropathy	220
Integration of machine learning and experimental validation reveals new lipid-lowering drug candidates	164
Identification of Licoflavone C as a cap-dependent endonuclease inhibitor against severe fever with thrombocytopenia syndrome virus	141
Translin deletion impairs cocaine-induced locomotor sensitization and RGS8 expression in the nucleus accumbens	129
Zonisamide attenuates pressure overload-induced myocardial hypertrophy in mice through proteasome inhibition	119
Magnolin overcomes EGFR TKI resistance in NSCLC by modulation of NDRG1-NRG2-HECW1 pathway	116
Compound 38, a novel potent and selective antagonist of adenosine A2A receptor, enhances arousal in mice	108
S670, an amide derivative of 3-O-acetyl-11-keto-β-boswellic acid, induces ferroptosis in human glioblastoma cells by generating ROS and inhibiting STX17-mediated fusion of autophagosome and lysosome	101
Reducing lipid peroxidation attenuates stress-induced susceptibility to herpes simplex virus type 1	94
Cystathionine γ-lyase-derived H2S negatively regulates thymic egress via allosteric inhibition of sphingosine-1-phosphate lyase	92
Iguratimod suppresses plasma cell differentiation and ameliorates experimental Sjögren’s syndrome in mice by promoting TEC kinase degradation	92
Celastrol suppresses the growth of vestibular schwannoma in mice by promoting the degradation of β-catenin	89
Ginsenoside Rg1 ameliorates stress-exacerbated Parkinson’s disease in mice by eliminating RTP801 and α-synuclein autophagic degradation obstacle	86
MC1R and melanin-based molecular probes for theranostic of melanoma and beyond	84
The hybrid oncolytic peptide NTP-385 potently inhibits adherent cancer cells by targeting the nucleus	79
GRK2-mediated phosphorylation and de-succinylation of PKM2 reduce macrophage glycolysis in rheumatoid arthritis	75
Single-dose methamphetamine administration impairs ORM retrieval in mice via excessive DA-mediated inhibition of PrLGlu activity	75
Channelopathy of small- and intermediate-conductance Ca2+-activated K+ channels	72
Pyroptosis and pyroptosis-inducing cancer drugs	70
Extracellular vesicles in vascular remodeling	68
tRF3-IleAAT reduced extracellular matrix synthesis in diabetic kidney disease mice by targeting ZNF281 and inhibiting ferroptosis	67
Otilonium bromide ameliorates pulmonary fibrosis in mice through activating phosphatase PPM1A	67
Targeted degradation of membrane and extracellular proteins with LYTACs	67
Activating Wnt/β-catenin signaling by autophagic degradation of APC contributes to the osteoblast differentiation effect of soy isoflavone on osteoporotic mesenchymal stem cells	63

Aspirin triggers ferroptosis in hepatocellular carcinoma cells through restricting NF-κB p65-activated SLC7A11 transcription	63
Author Correction: ADH1C inhibits progression of colorectal cancer through the ADH1C/PHGDH /PSAT1/serine metabolic pathway	61
Trametinib, an anti-tumor drug, promotes oligodendrocytes generation and myelin formation	61
Correction to: EPHA2 feedback activation limits the response to PDEδ inhibition in KRAS-dependent cancer cells	61
Resibufogenin ameliorates cerebral ischemia-reperfusion injury by modulating microglial redox homeostasis via Keap1-Nrf2-TFR1/ARE axis	57
Insomnia-related rodent models in drug discovery	56
143D, a novel selective KRASG12C inhibitor exhibits potent antitumor activity in preclinical models	56
Retraction Note: Physcion inhibits the metastatic potential of human colorectal cancer SW620 cells in vitro by suppressing the transcription factor SOX2	55
Dual-responsive nanoparticles loading bevacizumab and gefitinib for molecular targeted therapy against non-small cell lung cancer	54
Exploring the distinct activation mechanisms of neuromedin B receptor through multiple replica molecular dynamics simulations and Markov state modeling	54
Gastrodin promotes CNS myelinogenesis and alleviates demyelinating injury by activating the PI3K/AKT/mTOR signaling	54
Discovery and pharmacological characterization of 1,2,3,4-tetrahydroquinoline derivatives as RORγ inverse agonists against prostate cancer	54
FX5, a non-steroidal glucocorticoid receptor antagonist, ameliorates diabetic cognitive impairment in mice	53
Structure basis for inhibition of SARS-CoV-2 by the feline drug GC376	53
Hernandezine induces autophagic cell death in human pancreatic cancer cells via activation of the ROS/AMPK signaling pathway	50
DNMT inhibition epigenetically restores the cGAS-STING pathway and activates RIG-I/MDA5-MAVS to enhance antitumor immunity	48
Dendritic cell-liposome conjugates reverse immunosuppressive tumor microenvironment for inhibiting colitis-associated colorectal cancer	47
p52-ZER6: a determinant of tumor cell sensitivity to MDM2-p53 binding inhibitors	47
LN-439A, a novel BAP1 inhibitor, suppresses the growth of basal-like breast cancer by degrading KLF5	46
Mitochondrial calcium uniporter promotes kidney aging in mice through inducing mitochondrial calcium-mediated renal tubular cell senescence	45
Transcriptional regulation and small compound targeting of ACE2 in lung epithelial cells	45