Acta Pharmacologica Sinica

Article	Citations
Effects of site-directed mutagenesis of GLP-1 and glucagon receptors on signal transduction activated by dual and triple agonists	230
Baicalein ameliorates chronic itch in ACD mice by suppressing the spinal astrocytic STAT3–LCN2 cascade	139
Activation of D2-like dopamine receptors improves the neuronal network and cognitive function of PPT1KI mice	115
G3BP2 promotes tumor progression and gemcitabine resistance in PDAC via regulating PDIA3-DKC1-hENT in a stress granules-dependent manner	111
Costunolide normalizes neuroinflammation and improves neurogenesis deficits in a mouse model of depression through inhibiting microglial Akt/mTOR/NF-κB pathway	94
FGF21, a modulator of astrocyte reactivity, protects against ischemic brain injury through anti-inflammatory and neurotrophic pathways	93
Author Correction: The novel sophoridine derivate IMB-HDC induced lessened phosphorylation of STAT5a at 694 and 780 and promoted DNA breakage and cell apoptosis via blocking STAT5a nuclear translocati	90
Involvement of cell shape and lipid metabolism in glioblastoma resistance to temozolomide	85
FOXO3a protects glioma cells against temozolomide-induced DNA double strand breaks via promotion of BNIP3-mediated mitophagy	84
Combination of eriocalyxin B and homoharringtonine exerts synergistic anti-tumor effects against t(8;21) AML	84
Natural product-based screening led to the discovery of a novel PXR agonist with anti-cholestasis activity	81
Channelopathy of small- and intermediate-conductance Ca2+-activated K+ channels	79
Deep learning enables the discovery of a novel cuproptosis-inducing molecule for the inhibition of hepatocellular carcinoma	75
Inhibition of CD36 ameliorates mouse spinal cord injury by accelerating microglial lipophagy	72
Author Correction: THBru attenuates diabetic cardiomyopathy by inhibiting RAGE-dependent inflammation	72
Concurrent inhibition of p300/CBP and FLT3 enhances cytotoxicity and overcomes resistance in acute myeloid leukemia	71
Pyk2 inhibition attenuates hypoxic-ischemic brain injury in neonatal mice	68
Cardiorenal syndrome: clinical diagnosis, molecular mechanisms and therapeutic strategies	68
Construction of stable membranal CMTM6-PD-L1 full-length complex to evaluate the PD-1/PD-L1-CMTM6 interaction and develop anti-tumor anti-CMTM6 nanobody	68
Allisartan isoproxil reduces mortality of stroke-prone rats and protects against cerebrovascular, cardiac, and aortic damage	67
Cardiac-specific deletion of BRG1 ameliorates ventricular arrhythmia in mice with myocardial infarction	66
Inhibition of USP10 induces myeloma cell apoptosis by promoting cyclin D3 degradation	62
Activating Wnt/β-catenin signaling by autophagic degradation of APC contributes to the osteoblast differentiation effect of soy isoflavone on osteoporotic mesenchymal stem cells	60
Brigatinib, a newly discovered AXL inhibitor, suppresses AXL-mediated acquired resistance to osimertinib in EGFR-mutated non-small cell lung cancer	58
New horizons for the role of RNA N6-methyladenosine modification in hepatocellular carcinoma	55

PPAR-γ alleviates the inflammatory response in TNF-α-induced fibroblast-like synoviocytes by binding to p53 in rheumatoid arthritis	54
MC1R and melanin-based molecular probes for theranostic of melanoma and beyond	53
Chloroquine enhances the efficacy of chemotherapy drugs against acute myeloid leukemia by inactivating the autophagy pathway	52
PBPK-PD model for predicting morphine pharmacokinetics, CNS effects and naloxone antagonism in humans	51
Piezo1 channel activation facilitates baroreflex afferent neurotransmission with subsequent blood pressure reduction in control and hypertension rats	50
Dual-omics reveals temporal differences in acute sympathetic stress-induced cardiac inflammation following α1 and β-adrenergic receptors activation	49
1-Indanone retards cyst development in ADPKD mouse model by stabilizing tubulin and down-regulating anterograde transport of cilia	49
A dual role of lysophosphatidic acid type 2 receptor (LPAR2) in nonsteroidal anti-inflammatory drug-induced mouse enteropathy	49
Rational application of gefitinib in NSCLC patients with sensitive EGFR mutations based on pharmacokinetics and metabolomics	48
Antitumor pharmacological research in the era of personalized medicine	48
Dysregulation of iron homeostasis and methamphetamine reward behaviors in Clk1-deficient mice	47
Second messenger 2'3'-cyclic GMP-AMP (2'3'-cGAMP): the cell autonomous and non-autonomous roles in cancer progression	47
Adiponectin receptor agonist AdipoRon modulates human and mouse platelet function	47
S670, an amide derivative of 3-O-acetyl-11-keto-β-boswellic acid, induces ferroptosis in human glioblastoma cells by generating ROS and inhibiting STX17-mediated fusion of autophagosome and lysosome	46
PHLDA1 contributes to hypoxic ischemic brain injury in neonatal rats via inhibiting FUNDC1-mediated mitophagy	46
Engineered nanomedicines block the PD-1/PD-L1 axis for potentiated cancer immunotherapy	46
Characterization of LTr1 derived from cruciferous vegetables as a novel anti-glioma agent via inhibiting TrkA/PI3K/AKT pathway	44
Hederacoside C ameliorates colitis via restoring impaired intestinal barrier through moderating S100A9/MAPK and neutrophil recruitment inactivation	44
Circular RNA hsa_circ_0000288 protects against epilepsy in mice by binding to and stabilizing caprin1 protein	43
Antidepressant-like effects of cinnamamide derivative M2 via D2 receptors in the mouse medial prefrontal cortex	43
Paris saponin VII, a Hippo pathway activator, induces autophagy and exhibits therapeutic potential against human breast cancer cells	43
YTHDF3-mediated FLCN/cPLA2 axis improves cardiac fibrosis via suppressing lysosomal function	43
Correction: A novel annexin dimer targets microglial phagocytosis of astrocytes to protect the brain-blood barrier after cerebral ischemia	42
Rg1 exerts protective effect in CPZ-induced demyelination mouse model via inhibiting CXCL10-mediated glial response	40
Intestinal human carboxylesterase 2 (CES2) expression rescues drug metabolism and most metabolic syndrome phenotypes in global Ces2 cluster knockout mice	39
How improvements in US FDA regulatory process and procedures led to the drug approval for first ever treatment of a common liver disease	39
Endothelial cell Orai1 is essential for endothelium-dependent contraction of mouse carotid arteries in normotensive and hypertensive mice	38
Prenatal dexamethasone exposure programs the decreased testosterone synthesis in offspring rats by low level of endogenous glucocorticoids	37
Prenatal inflammation exposure-programmed hypertension exhibits multi-generational inheritance via disrupting DNA methylome	37
Acquisition of taxane resistance by p53 inactivation in ovarian cancer cells	37
Iguratimod suppresses plasma cell differentiation and ameliorates experimental Sjögren’s syndrome in mice by promoting TEC kinase degradation	37
A novel and effective approach to generate germline-like monoclonal antibodies by integration of phage and mammalian cell display platforms	36
Oral FPR2/ALX modulators tune myeloid cell activity to ameliorate mucosal inflammation in inflammatory bowel disease	36
Pyroptosis and pyroptosis-inducing cancer drugs	35
Extracellular vesicles in vascular remodeling	35
Multi-compound and drug-combination pharmacokinetic research on Chinese herbal medicines	35
Anemoside B4 inhibits enterovirus 71 propagation in mice through upregulating 14-3-3 expression and type I interferon responses	35
Modified citrus pectin inhibits breast cancer development in mice by targeting tumor-associated macrophage survival and polarization in hypoxic microenvironment	35
Estrogen-dependent depressor response of melatonin via baroreflex afferent function and intensification of PKC-mediated Nav1.9 activation	34
All-trans retinoic acid impairs glucose-stimulated insulin secretion by activating the RXR/SREBP-1c/UCP2 pathway	34
The modulation of PD-L1 induced by the oncogenic HBXIP for breast cancer growth	34
Krüppel-like factors: potential roles in blood-brain barrier dysfunction and epileptogenesis	33
Activation of the endocannabinoid system mediates cardiac hypertrophy induced by rosiglitazone	33
ADT-OH inhibits malignant melanoma metastasis in mice via suppressing CSE/CBS and FAK/Paxillin signaling pathway	33
Protective effects of curcumin on desipramine-induced islet β-cell damage via AKAP150/PKA/PP2B complex	32
Celastrol suppresses the growth of vestibular schwannoma in mice by promoting the degradation of β-catenin	32
Human amniotic epithelial stem cell is a cell therapy candidate for preventing acute graft-versus-host disease	31
Updates on novel pharmacotherapeutics for the treatment of nonalcoholic steatohepatitis	31
Single-dose methamphetamine administration impairs ORM retrieval in mice via excessive DA-mediated inhibition of PrLGlu activity	31
Cystathionine γ-lyase-derived H2S negatively regulates thymic egress via allosteric inhibition of sphingosine-1-phosphate lyase	31

Gout-associated monosodium urate crystal-induced necrosis is independent of NLRP3 activity but can be suppressed by combined inhibitors for multiple signaling pathways	30
Fatty acid-binding protein 7 triggers α-synuclein oligomerization in glial cells and oligodendrocytes associated with oxidative stress	30
Otilonium bromide ameliorates pulmonary fibrosis in mice through activating phosphatase PPM1A	29
ABBV-744 alleviates LPS-induced neuroinflammation via regulation of BATF2-IRF4-STAT1/3/5 axis	29
Targeted degradation of membrane and extracellular proteins with LYTACs	29
BL-918, a small-molecule activator of ULK1, induces cytoprotective autophagy for amyotrophic lateral sclerosis therapy	29
Discovery and characterization of a novel cGAS covalent inhibitor for the treatment of inflammatory bowel disease	29
Compound 38, a novel potent and selective antagonist of adenosine A2A receptor, enhances arousal in mice	29
Activating α7nAChR ameliorates abdominal aortic aneurysm through inhibiting pyroptosis mediated by NLRP3 inflammasome	28
SGLT2 inhibitors ameliorate NAFLD in mice via downregulating PFKFB3, suppressing glycolysis and modulating macrophage polarization	28
NADPHnet: a novel strategy to predict compounds for regulation of NADPH metabolism via network-based methods	28
Desloratadine alleviates ALS-like pathology in hSOD1G93A mice via targeting 5HTR2A on activated spinal astrocytes	28
Artemisinin derivative SM934 in the treatment of autoimmune and inflammatory diseases: therapeutic effects and molecular mechanisms	28
Author Correction: DCZ5248, a novel dual inhibitor of Hsp90 and autophagy, exerts antitumor activity against colon cancer	27
Cinnamaldehyde induces autophagy-mediated cell death through ER stress and epigenetic modification in gastric cancer cells	27
Satellite cell-derived exosome-mediated delivery of microRNA-23a/27a/26a cluster ameliorates the renal tubulointerstitial fibrosis in mouse diabetic nephropathy	27
Publisher Correction: E3 ubiquitin ligase UBR5 modulates circadian rhythm by facilitating the ubiquitination and degradation of the key clock transcription factor BMAL1	26
Adaptor protein CEMIP reduces the chemosensitivity of small cell lung cancer via activation of an SRC-YAP oncogenic module	26
Author Correction: Discovery of toxoflavin, a potent IRE1α inhibitor acting through structure-dependent oxidative inhibition	26
SARS-CoV-2 receptor binding domain radio-probe: a non-invasive approach for angiotensin-converting enzyme 2 mapping in mice	25
Publisher Correction: Publisher correction for multiple articles	25
Author Correction: QAP14 suppresses stemness and metastasis of breast cancer via the activation of dopamine D1 receptor	25
Oncoprotein LAMTOR5-mediated CHOP silence via DNA hypermethylation and miR-182/miR-769 in promotion of liver cancer growth	25
Pharmacologically significant constituents collectively responsible for anti-sepsis action of XueBiJing, a Chinese herb-based intravenous formulation	25
Darinaparsin (ZIO-101) enhances the sensitivity of small-cell lung cancer to PARP inhibitors	25
Hepatocyte-derived MANF mitigates ethanol-induced liver steatosis in mice via enhancing ASS1 activity and activating AMPK pathway	24
LncRNA-6395 promotes myocardial ischemia-reperfusion injury in mice through increasing p53 pathway	24
GLP-1 mimetics as a potential therapy for nonalcoholic steatohepatitis	24
INHBA promotes tumor growth and induces resistance to PD-L1 blockade by suppressing IFN-γ signaling	24
PGAM5 exacerbates acute renal injury by initiating mitochondria-dependent apoptosis by facilitating mitochondrial cytochrome c release	24
MANF ameliorates DSS-induced mouse colitis via restricting Ly6ChiCX3CR1int macrophage transformation and suppressing CHOP-BATF2 signaling pathway	24
Ginsenoside Rg1 ameliorates stress-exacerbated Parkinson’s disease in mice by eliminating RTP801 and α-synuclein autophagic degradation obstacle	23
Wogonin protects glomerular podocytes by targeting Bcl-2-mediated autophagy and apoptosis in diabetic kidney disease	23
mTOR regulates cocaine-induced behavioural sensitization through the SynDIG1–GluA2 interaction in the nucleus accumbens	23
Role of TRPM2 in brain tumours and potential as a drug target	23
Macrophages promote the transition from myocardial ischemia reperfusion injury to cardiac fibrosis in mice through GMCSF/CCL2/CCR2 and phenotype switching	23
BNIP3-mediated mitophagy attenuates hypoxic–ischemic brain damage in neonatal rats by inhibiting ferroptosis through P62–KEAP1–NRF2 pathway activation to maintain iron and redox homeostasis	23
JMJD6 protects against isoproterenol-induced cardiac hypertrophy via inhibition of NF-κB activation by demethylating R149 of the p65 subunit	22
Signaling profiles in HEK 293T cells co-expressing GLP-1 and GIP receptors	22
Aspirin triggers ferroptosis in hepatocellular carcinoma cells through restricting NF-κB p65-activated SLC7A11 transcription	22
GPR97 deficiency ameliorates renal interstitial fibrosis in mouse hypertensive nephropathy	22
Zonisamide attenuates pressure overload-induced myocardial hypertrophy in mice through proteasome inhibition	22
Fisetin ameliorates fibrotic kidney disease in mice via inhibiting ACSL4-mediated tubular ferroptosis	21
Inhibition of HIF-prolyl hydroxylase promotes renal tubule regeneration via the reprogramming of renal proximal tubular cells	21
Neuropeptide-mediated activation of astrocytes improves stress resilience in mice by modulating cortical neural synapses	21
The classical D1 dopamine receptor antagonist SCH23390 is a functional sigma-1 receptor allosteric modulator	21
Activation of glutamine synthetase (GS) as a new strategy for the treatment of major depressive disorder and other GS-related diseases	21
Hepatocyte-derived VEGFA accelerates the progression of non-alcoholic fatty liver disease to hepatocellular carcinoma via activating hepatic stellate cells	21
IMPDH inhibitors upregulate PD-L1 in cancer cells without impairing immune checkpoint inhibitor efficacy	21
tRF3-IleAAT reduced extracellular matrix synthesis in diabetic kidney disease mice by targeting ZNF281 and inhibiting ferroptosis	21
RNA-binding motif protein RBM39 enhances the proliferation of gastric cancer cells by facilitating an oncogenic splicing switch in MRPL33	21
Angiogenesis after ischemic stroke	21
Aminoacylase-1 plays a key role in myocardial fibrosis and the therapeutic effects of 20(S)-ginsenoside Rg3 in mouse heart failure	20
ADH1C inhibits progression of colorectal cancer through the ADH1C/PHGDH /PSAT1/serine metabolic pathway	20
Lethal pulmonary thromboembolism in mice induced by intravenous human umbilical cord mesenchymal stem cell-derived large extracellular vesicles in a dose- and tissue factor-dependent manner	20
Notoginsenoside R1 protects against myocardial ischemia/reperfusion injury in mice via suppressing TAK1-JNK/p38 signaling	20
Transforming growth factor-β receptors: versatile mechanisms of ligand activation	20
Sorafenib triggers ferroptosis via inhibition of HBXIP/SCD axis in hepatocellular carcinoma	20
Reducing lipid peroxidation attenuates stress-induced susceptibility to herpes simplex virus type 1	20
ACT001 inhibits pituitary tumor growth by inducing autophagic cell death via MEK4/MAPK pathway	20
Botulinum neurotoxin A ameliorates depressive-like behavior in a reserpine-induced Parkinson’s disease mouse model via suppressing hippocampal microglial engulfment and neuroinflammation	20
Dl-3-n-butylphthalide promotes angiogenesis in ischemic stroke mice through upregulating autocrine and paracrine sonic hedgehog	19
Triptolide protects against white matter injury induced by chronic cerebral hypoperfusion in mice	19
Quinpirole ameliorates nigral dopaminergic neuron damage in Parkinson’s disease mouse model through activating GHS-R1a/D2R heterodimers	19
New monoamine antidepressant, hypidone hydrochloride (YL-0919), enhances the excitability of medial prefrontal cortex in mice via a neural disinhibition mechanism	19
Novel Caspase-1 inhibitor CZL80 improves neurological function in mice after progressive ischemic stroke within a long therapeutic time-window	19
Identification of Licoflavone C as a cap-dependent endonuclease inhibitor against severe fever with thrombocytopenia syndrome virus	19
Humanized cerebral organoids-based ischemic stroke model for discovering of potential anti-stroke agents	19
The hybrid oncolytic peptide NTP-385 potently inhibits adherent cancer cells by targeting the nucleus	19
A novel resveratrol analog upregulates sirtuin 1 and inhibits inflammatory cell infiltration in acute pancreatitis	19
Flavokawain B alleviates LPS-induced acute lung injury via targeting myeloid differentiation factor 2	19
CircNSD1 promotes cardiac fibrosis through targeting the miR-429-3p/SULF1/Wnt/β-catenin signaling pathway	19
MK2206 attenuates atherosclerosis by inhibiting lipid accumulation, cell migration, proliferation, and inflammation	19
The novel STAT3 inhibitor WZ-2-033 causes regression of human triple-negative breast cancer and gastric cancer xenografts	19
A novel selective ERK1/2 inhibitor, Laxiflorin B, targets EGFR mutation subtypes in non-small-cell lung cancer	19
Sulforaphane ameliorates non-alcoholic fatty liver disease in mice by promoting FGF21/FGFR1 signaling pathway	19
Furmonertinib (Alflutinib, AST2818) is a potential positive control drug comparable to rifampin for evaluation of CYP3A4 induction in sandwich-cultured primary human hepatocytes	18
Levo-tetrahydropalmatine inhibits α4β2 nicotinic receptor response to nicotine in cultured SH-EP1 cells	18
N-acetylcysteine facilitates extinction of cued fear memory in rats via reestablishing basolateral amygdala glutathione homeostasis	18
Naphthylisoquinoline alkaloids, a new structural template inhibitor of Nav1.7 sodium channel	18

p52-ZER6: a determinant of tumor cell sensitivity to MDM2-p53 binding inhibitors	18
Alpha lipoamide inhibits diabetic kidney fibrosis via improving mitochondrial function and regulating RXRα expression and activation	18
Computationally guided discovery of novel non-steroidal AR-GR dual antagonists demonstrating potency against antiandrogen resistance	18
CHMFL-26 is a highly potent irreversible HER2 inhibitor for use in the treatment of HER2-positive and HER2-mutant cancers	18
Aberrant neuronal excitation promotes neuroinflammation in the primary motor cortex of ischemic stroke mice	17
P300/CBP inhibition sensitizes mantle cell lymphoma to PI3Kδ inhibitor idelalisib	17
LPA suppresses HLA-DR expression in human melanoma cells: a potential immune escape mechanism involving LPAR1 and DR6-mediated release of IL-10	17
Discovery of FO-4-15, a novel 1,2,4-oxadiazole derivative, ameliorates cognitive impairments in 3×Tg mice by activating the mGluR1/CaMKIIα pathway	17
Dual-responsive nanoparticles loading bevacizumab and gefitinib for molecular targeted therapy against non-small cell lung cancer	17
MMP-9 inhibitor SB-3CT improves neurological outcomes in ischemic stroke mice by modulation of astrocytic lipid metabolism	17
143D, a novel selective KRASG12C inhibitor exhibits potent antitumor activity in preclinical models	17
Novel CDK9 inhibitor oroxylin A promotes wild-type P53 stability and prevents hepatocellular carcinoma progression by disrupting both MDM2 and SIRT1 signaling	17
Transport mechanism and drug discovery of human monocarboxylate transporter 1	17
Chronic infusion of ELABELA alleviates vascular remodeling in spontaneously hypertensive rats via anti-inflammatory, anti-oxidative and anti-proliferative effects	17
Author Correction: c-FLIP promotes drug resistance in non-small-cell lung cancer cells via upregulating FoxM1 expression	17
Foxp3 inhibitory peptide encapsulated in a novel CD25-targeted nanoliposome promotes efficient tumor regression in mice	17
ARID3a from the ARID family: structure, role in autoimmune diseases and drug discovery	16
Vagus nerve stimulation as a promising neuroprotection for ischemic stroke via α7nAchR-dependent inactivation of microglial NLRP3 inflammasome	16
Baicalein attenuates rotenone-induced SH-SY5Y cell apoptosis through binding to SUR1 and activating ATP-sensitive potassium channels	16
Role of thrombospondin-1 in high-salt–induced mesenteric artery endothelial impairment in rats	16
The transplantation of rapamycin-treated senescent human mesenchymal stem cells with enhanced proangiogenic activity promotes neovascularization and ischemic limb salvage in mice	16
Repurposing of the FGFR inhibitor AZD4547 as a potent inhibitor of necroptosis by selectively targeting RIPK1	16
Antagonism of histamine H3 receptor promotes angiogenesis following focal cerebral ischemia	16
Upregulation of wild-type p53 by small molecule-induced elevation of NQO1 in non-small cell lung cancer cells	16
Aristolochic acids-hijacked p53 promotes liver cancer cell growth by inhibiting ferroptosis	16
Author Correction: Tetrahydroberberrubine retards heart aging in mice by promoting PHB2-mediated mitophagy	15
Structural basis of tolvaptan binding to the vasopressin V2 receptor	15
Roflupram protects against rotenone-induced neurotoxicity and facilitates α-synuclein degradation in Parkinson’s disease models	15
Myeloid-derived growth factor suppresses VSMC dedifferentiation and attenuates postinjury neointimal formation in rats by activating S1PR2 and its downstream signaling	15
Empagliflozin ameliorates vascular calcification in diabetic mice through inhibiting Bhlhe40-dependent NLRP3 inflammasome activation	15
Differential modulation of subthalamic projection neurons by short-term and long-term electrical stimulation in physiological and parkinsonian conditions	15
Liver X receptor inverse agonist SR9243 attenuates rheumatoid arthritis via modulating glycolytic metabolism of macrophages	15
The caspase-1 inhibitor VX765 upregulates connexin 43 expression and improves cell–cell communication after myocardial infarction via suppressing the IL-1β/p38 MAPK pathway	15
Cinnamaldehyde prevents intergenerational effect of paternal depression in mice via regulating GR/miR-190b/BDNF pathway	14
Inhibition of Nav1.7 channel by a novel blocker QLS-81 for alleviation of neuropathic pain	14
Pharmacological characterization of the small molecule 03A10 as an inhibitor of α-synuclein aggregation for Parkinson’s disease treatment	14
CCDC92 promotes podocyte injury by regulating PA28α/ABCA1/cholesterol efflux axis in type 2 diabetic mice	14
124I-labeled anti-CD147 antibody for noninvasive detection of CD147-positive pan-cancers: construction and preclinical studies	14
Thermoregulatory pathway underlying the pyrogenic effects of prostaglandin E2 in the lateral parabrachial nucleus of male rats	14
Identification of HMGCR as the anticancer target of physapubenolide against melanoma cells by in silico target prediction	14
All about NASH: disease biology, targets, and opportunities on the road to NASH drugs	14
Nucleic acid and protein methylation modification in renal diseases	14
Atranorin inhibits NLRP3 inflammasome activation by targeting ASC and protects NLRP3 inflammasome-driven diseases	14
Design, synthesis and pharmacological characterization of N-(3-ethylbenzo[d]isoxazol-5-yl) sulfonamide derivatives as BRD4 inhibitors against acute myeloid leukemia	14
Discovery and pharmacological characterization of 1,2,3,4-tetrahydroquinoline derivatives as RORγ inverse agonists against prostate cancer	14
Inhibition of PPP1R15A alleviates osteoporosis via suppressing RANKL-induced osteoclastogenesis	14
Serum granulosa cell-derived TNF-α promotes inflammation and apoptosis of renal tubular cells and PCOS-related kidney injury through NF-κB signaling	14
Inhibiting the transcription and replication of Ebola viruses by disrupting the nucleoprotein and VP30 protein interaction with small molecules	14
19F qNMR based pharmacokinetics, metabolism and mass balance studies of SARS-CoV-2-3CL protease inhibitor simnotrelvir (SIM0417) in humans	14
cGAS and cancer therapy: a double-edged sword	14
Protection against glutathione depletion-associated oxidative neuronal death by neurotransmitters norepinephrine and dopamine: Protein disulfide isomerase as a mechanistic target for neuroprotection	14
Knockout of interleukin-17A diminishes ventricular arrhythmia susceptibility in diabetic mice via inhibiting NF-κB-mediated electrical remodeling	14
Author Correction: ADH1C inhibits progression of colorectal cancer through the ADH1C/PHGDH /PSAT1/serine metabolic pathway	13
Transcriptional regulation and small compound targeting of ACE2 in lung epithelial cells	13
Mitochondrial calcium uniporter promotes kidney aging in mice through inducing mitochondrial calcium-mediated renal tubular cell senescence	13
Intestinal epithelial Krüppel-like factor 4 alleviates endotoxemia and atherosclerosis through improving NF-κB/miR-34a-mediated intestinal permeability	13
Cannabinoid-2 receptor depletion promotes non-alcoholic fatty liver disease in mice via disturbing gut microbiota and tryptophan metabolism	13
Author Correction: Ginsenoside Rg1 protects against ischemic/reperfusion-induced neuronal injury through miR-144/Nrf2/ARE pathway	13
Neddylation of RhoA impairs its protein degradation and promotes renal interstitial fibrosis progression in diabetic nephropathy	13
Trilobatin rescues cognitive impairment of Alzheimer’s disease by targeting HMGB1 through mediating SIRT3/SOD2 signaling pathway	13
Dihydroartemisinin suppresses renal fibrosis in mice by inhibiting DNA-methyltransferase 1 and increasing Klotho	13
Pentapeptide PYRAE triggers ER stress-mediated apoptosis of breast cancer cells in mice by targeting RHBDF1-BiP interaction	13
Author Correction: Wogonin suppresses osteopontin expression in adipocytes by activating PPARα	13
Chemoproteomics reveals proteome-wide covalent and non-covalent targets of withaferin A	13
Author Correction: Asperosaponin VI promotes angiogenesis and accelerates wound healing in rats via up-regulating HIF-1α/VEGF signaling	13
Trametinib, an anti-tumor drug, promotes oligodendrocytes generation and myelin formation	13
CDDO-Im ameliorates osteoarthritis and inhibits chondrocyte apoptosis in mice via enhancing Nrf2-dependent autophagy	13
Identification of pimavanserin tartrate as a potent Ca2+-calcineurin-NFAT pathway inhibitor for glioblastoma therapy	13
Ursolic acid enhances autophagic clearance and ameliorates motor and non-motor symptoms in Parkinson’s disease mice model	13
Pramipexole inhibits astrocytic NLRP3 inflammasome activation via Drd3-dependent autophagy in a mouse model of Parkinson’s disease	13
Author Correction: A new tau dephosphorylation-targeting chimera for the treatment of tauopathies	13
IMM-H007 attenuates isoprenaline-induced cardiac fibrosis through targeting TGFβ1 signaling pathway	13
Gastrodin promotes CNS myelinogenesis and alleviates demyelinating injury by activating the PI3K/AKT/mTOR signaling	13
Exploring immunotherapeutic strategies for neurodegenerative diseases: a focus on Huntington’s disease and Prion diseases	13
Correction to: EPHA2 feedback activation limits the response to PDEδ inhibition in KRAS-dependent cancer cells	13
Danshensu alleviates pseudo-typed SARS-CoV-2 induced mouse acute lung inflammation	13
Bispecific antibody simultaneously targeting PD1 and HER2 inhibits tumor growth via direct tumor cell killing in combination with PD1/PDL1 blockade and HER2 inhibition	13
Insomnia-related rodent models in drug discovery	13
Silibinin relieves UVB-induced apoptosis of human skin cells by inhibiting the YAP-p73 pathway	13
β-arrestin2: an emerging player and potential therapeutic target in inflammatory immune diseases	13
Author Correction: Amygdala dynorphin/κ opioid receptor system modulates depressive-like behavior in mice following chronic social defeat stress	13
Structure basis for inhibition of SARS-CoV-2 by the feline drug GC376	13
Sortilin deletion in the prefrontal cortex and hippocampus ameliorates depressive-like behaviors in mice via regulating ASM/ceramide signaling	13
LN-439A, a novel BAP1 inhibitor, suppresses the growth of basal-like breast cancer by degrading KLF5	13
SEC62-dependent ER-phagy contributes to apelin-13/APJ-induced monocyte-vascular endothelial cell adhesion in atherosclerosis pathogenesis	13