Acta Pharmacologica Sinica

Papers
(The TQCC of Acta Pharmacologica Sinica is 16. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2020-04-01 to 2024-04-01.)
ArticleCitations
Structural and functional properties of SARS-CoV-2 spike protein: potential antivirus drug development for COVID-191541
Anti-SARS-CoV-2 activities in vitro of Shuanghuanglian preparations and bioactive ingredients309
Hypoxia, HIF-1α, and COVID-19: from pathogenic factors to potential therapeutic targets153
Artesunate synergizes with sorafenib to induce ferroptosis in hepatocellular carcinoma146
Natural products: potential treatments for cisplatin-induced nephrotoxicity144
Drp1-dependent mitochondrial fission in cardiovascular disease133
Endothelial dysfunction in COVID-19: an overview of evidence, biomarkers, mechanisms and potential therapies104
Caspase-11/4 and gasdermin D-mediated pyroptosis contributes to podocyte injury in mouse diabetic nephropathy98
Engineering nanomedicines through boosting immunogenic cell death for improved cancer immunotherapy95
Matrine attenuates pathological cardiac fibrosis via RPS5/p38 in mice86
Sirtuin 3 deficiency exacerbates diabetic cardiomyopathy via necroptosis enhancement and NLRP3 activation85
ACSL4 is a predictive biomarker of sorafenib sensitivity in hepatocellular carcinoma83
Baicalin prevents LPS-induced activation of TLR4/NF-κB p65 pathway and inflammation in mice via inhibiting the expression of CD1470
Mitochondrial-derived damage-associated molecular patterns amplify neuroinflammation in neurodegenerative diseases67
NRF2-GPX4/SOD2 axis imparts resistance to EGFR-tyrosine kinase inhibitors in non-small-cell lung cancer cells61
ATF3 contributes to brucine-triggered glioma cell ferroptosis via promotion of hydrogen peroxide and iron60
Identification of SARS-CoV-2 entry inhibitors among already approved drugs59
Structure genomics of SARS-CoV-2 and its Omicron variant: drug design templates for COVID-1958
Wogonin protects glomerular podocytes by targeting Bcl-2-mediated autophagy and apoptosis in diabetic kidney disease57
Deletion of TLR4 attenuates lipopolysaccharide-induced acute liver injury by inhibiting inflammation and apoptosis57
Ex vivo pulsed dendritic cell vaccination against cancer57
Luteolin alleviates cognitive impairment in Alzheimer’s disease mouse model via inhibiting endoplasmic reticulum stress-dependent neuroinflammation56
Mitochondrial aldehyde dehydrogenase (ALDH2) rescues cardiac contractile dysfunction in an APP/PS1 murine model of Alzheimer’s disease via inhibition of ACSL4-dependent ferroptosis56
DL-3-n-butylphthalide ameliorates diabetes-associated cognitive decline by enhancing PI3K/Akt signaling and suppressing oxidative stress54
Mutations in key driver genes of pancreatic cancer: molecularly targeted therapies and other clinical implications53
Baicalein ameliorates ulcerative colitis by improving intestinal epithelial barrier via AhR/IL-22 pathway in ILC3s53
Mitochondrial Ca2+ regulation in the etiology of heart failure: physiological and pathophysiological implications52
Baicalein attenuates cardiac hypertrophy in mice via suppressing oxidative stress and activating autophagy in cardiomyocytes52
New therapeutics beyond amyloid-β and tau for the treatment of Alzheimer’s disease51
Metformin and cancer immunity50
Recombinant human ACE2: potential therapeutics of SARS-CoV-2 infection and its complication48
NOD-like receptors in autoimmune diseases48
Harnessing nanomedicine to overcome the immunosuppressive tumor microenvironment48
Sirt1 inhibits renal tubular cell epithelial–mesenchymal transition through YY1 deacetylation in diabetic nephropathy48
The glycolytic process in endothelial cells and its implications47
Zinc as a countermeasure for cadmium toxicity44
Icariside II attenuates cerebral ischemia/reperfusion-induced blood–brain barrier dysfunction in rats via regulating the balance of MMP9/TIMP144
A multi-targeting drug design strategy for identifying potent anti-SARS-CoV-2 inhibitors44
Atomic force microscopy for revealing micro/nanoscale mechanics in tumor metastasis: from single cells to microenvironmental cues42
Therapeutic potential of colchicine in cardiovascular medicine: a pharmacological review42
Metformin promotes microglial cells to facilitate myelin debris clearance and accelerate nerve repairment after spinal cord injury42
Salvianolic acid A prevented cerebrovascular endothelial injury caused by acute ischemic stroke through inhibiting the Src signaling pathway41
Pyroptosis and pyroptosis-inducing cancer drugs40
Widespread myocardial dysfunction in COVID-19 patients detected by myocardial strain imaging using 2-D speckle-tracking echocardiography40
Tu-San-Qi (Gynura japonica): the culprit behind pyrrolizidine alkaloid-induced liver injury in China39
Cardamonin protects against lipopolysaccharide-induced myocardial contractile dysfunction in mice through Nrf2-regulated mechanism39
AlphaFold2 versus experimental structures: evaluation on G protein-coupled receptors38
Targeting HMGB1 for the treatment of sepsis and sepsis-induced organ injury38
Current advances in the use of exosomes, liposomes, and bioengineered hybrid nanovesicles in cancer detection and therapy37
Tetrandrine alleviates silicosis by inhibiting canonical and non-canonical NLRP3 inflammasome activation in lung macrophages37
Nanomedicine-based immunotherapy for central nervous system disorders37
Involvement of the secreted protein Metrnl in human diseases37
Ferroptosis in viral infection: the unexplored possibility37
Discovery of potential small molecular SARS-CoV-2 entry blockers targeting the spike protein37
Pharmacokinetics and tissue distribution of remdesivir and its metabolites nucleotide monophosphate, nucleotide triphosphate, and nucleoside in mice37
Blueberry-derived exosomes-like nanoparticles ameliorate nonalcoholic fatty liver disease by attenuating mitochondrial oxidative stress37
Celastrol induces lipophagy via the LXRα/ABCA1 pathway in clear cell renal cell carcinoma36
Overview of therapeutic drug research for COVID-19 in China36
Safety, tolerability, and pharmacokinetics of VV116, an oral nucleoside analog against SARS-CoV-2, in Chinese healthy subjects36
Melatonin promotes cardiomyocyte proliferation and heart repair in mice with myocardial infarction via miR-143-3p/Yap/Ctnnd1 signaling pathway36
Ginsenoside Rb1 alleviates diabetic kidney podocyte injury by inhibiting aldose reductase activity35
Cancer nanomedicine meets immunotherapy: opportunities and challenges34
Regulatory T cells in ischemic stroke34
Disulfiram-loaded lactoferrin nanoparticles for treating inflammatory diseases34
MDL-800, an allosteric activator of SIRT6, suppresses proliferation and enhances EGFR-TKIs therapy in non-small cell lung cancer34
Pyrroloquinoline quinone promotes mitochondrial biogenesis in rotenone-induced Parkinson’s disease model via AMPK activation34
Autophagy-dependent removal of α-synuclein: a novel mechanism of GM1 ganglioside neuroprotection against Parkinson’s disease34
Diterbutyl phthalate attenuates osteoarthritis in ACLT mice via suppressing ERK/c-fos/NFATc1 pathway, and subsequently inhibiting subchondral osteoclast fusion33
Emerging roles of class I PI3K inhibitors in modulating tumor microenvironment and immunity33
Synergistic antitumor activity of sorafenib and artesunate in hepatocellular carcinoma cells33
β-sitosterol ameliorates influenza A virus-induced proinflammatory response and acute lung injury in mice by disrupting the cross-talk between RIG-I and IFN/STAT signaling33
Bile acid and receptors: biology and drug discovery for nonalcoholic fatty liver disease32
TGFβ2-mediated epithelial–mesenchymal transition and NF-κB pathway activation contribute to osimertinib resistance32
Berberine remodels adipose tissue to attenuate metabolic disorders by activating sirtuin 332
Nanomedicines based on nanoscale metal-organic frameworks for cancer immunotherapy31
Catalpol improves impaired neurovascular unit in ischemic stroke rats via enhancing VEGF-PI3K/AKT and VEGF-MEK1/2/ERK1/2 signaling31
KLF4 initiates sustained YAP activation to promote renal fibrosis in mice after ischemia-reperfusion kidney injury31
STING inhibitor ameliorates LPS-induced ALI by preventing vascular endothelial cells-mediated immune cells chemotaxis and adhesion31
Short-chain fatty acids exert opposite effects on the expression and function of p-glycoprotein and breast cancer resistance protein in rat intestine31
Benzimidazoles induce concurrent apoptosis and pyroptosis of human glioblastoma cells via arresting cell cycle31
Chitosan oligosaccharide modified liposomes enhance lung cancer delivery of paclitaxel30
Nanomedicine and cancer immunotherapy30
Gasdermin E-derived caspase-3 inhibitors effectively protect mice from acute hepatic failure30
Structure, regulation, and biological functions of TIGAR and its role in diseases30
Intrinsic and acquired resistance to CDK4/6 inhibitors and potential overcoming strategies30
Berberine alleviates visceral hypersensitivity in rats by altering gut microbiome and suppressing spinal microglial activation30
Bispecific antibody simultaneously targeting PD1 and HER2 inhibits tumor growth via direct tumor cell killing in combination with PD1/PDL1 blockade and HER2 inhibition29
Application of targeted therapy strategies with nanomedicine delivery for atherosclerosis29
Polydatin attenuates renal fibrosis in diabetic mice through regulating the Cx32-Nox4 signaling pathway29
Ferroptosis inhibitor liproxstatin-1 alleviates metabolic dysfunction-associated fatty liver disease in mice: potential involvement of PANoptosis29
The m6A demethylase FTO promotes the osteogenesis of mesenchymal stem cells by downregulating PPARG28
Gout-associated monosodium urate crystal-induced necrosis is independent of NLRP3 activity but can be suppressed by combined inhibitors for multiple signaling pathways28
Lp-PLA2 inhibition prevents Ang II-induced cardiac inflammation and fibrosis by blocking macrophage NLRP3 inflammasome activation28
Suppression of the USP10/CCND1 axis induces glioblastoma cell apoptosis28
Pirfenidone ameliorates silica-induced lung inflammation and fibrosis in mice by inhibiting the secretion of interleukin-17A28
Puerarin ameliorated pressure overload-induced cardiac hypertrophy in ovariectomized rats through activation of the PPARα/PGC-1 pathway28
The artemisinin analog SM934 alleviates dry eye disease in rodent models by regulating TLR4/NF-κB/NLRP3 signaling27
Diosmetin has therapeutic efficacy in colitis regulating gut microbiota, inflammation, and oxidative stress via the circ-Sirt1/Sirt1 axis27
Pretreatment with chitosan oligosaccharides attenuate experimental severe acute pancreatitis via inhibiting oxidative stress and modulating intestinal homeostasis27
Dapagliflozin attenuates pressure overload-induced myocardial remodeling in mice via activating SIRT1 and inhibiting endoplasmic reticulum stress27
Ursolic acid reduces hepatocellular apoptosis and alleviates alcohol-induced liver injury via irreversible inhibition of CASP3 in vivo27
Ethyl ferulate protects against lipopolysaccharide-induced acute lung injury by activating AMPK/Nrf2 signaling pathway26
FOXO3a protects glioma cells against temozolomide-induced DNA double strand breaks via promotion of BNIP3-mediated mitophagy26
Probiotics protect against RSV infection by modulating the microbiota-alveolar-macrophage axis26
Garciesculenxanthone B induces PINK1-Parkin-mediated mitophagy and prevents ischemia-reperfusion brain injury in mice26
Tanshinone IIA prevents LPS-induced inflammatory responses in mice via inactivation of succinate dehydrogenase in macrophages26
6-Gingerol protects against cardiac remodeling by inhibiting the p38 mitogen-activated protein kinase pathway26
Cinnamaldehyde induces autophagy-mediated cell death through ER stress and epigenetic modification in gastric cancer cells25
Lipid/PAA-coated mesoporous silica nanoparticles for dual-pH-responsive codelivery of arsenic trioxide/paclitaxel against breast cancer cells25
Sphingomyelin synthase 2 facilitates M2-like macrophage polarization and tumor progression in a mouse model of triple-negative breast cancer25
Subtype-selective mechanisms of negative allosteric modulators binding to group I metabotropic glutamate receptors25
Inhibition of AXL enhances chemosensitivity of human ovarian cancer cells to cisplatin via decreasing glycolysis25
Nanoengineered targeting strategy for cancer immunotherapy24
GPR84 signaling promotes intestinal mucosal inflammation via enhancing NLRP3 inflammasome activation in macrophages24
Cinnamaldehyde protects against rat intestinal ischemia/reperfusion injuries by synergistic inhibition of NF-κB and p5324
Reduced nicotinamide adenine dinucleotide phosphate in redox balance and diseases: a friend or foe?24
Avasimibe exerts anticancer effects on human glioblastoma cells via inducing cell apoptosis and cell cycle arrest24
Clinical characteristics and related risk factors of disease severity in 101 COVID-19 patients hospitalized in Wuhan, China24
MicroRNA-99b-3p promotes angiotensin II-induced cardiac fibrosis in mice by targeting GSK-3β24
Caspase-11 promotes NLRP3 inflammasome activation via the cleavage of pannexin1 in acute kidney disease24
BMSC-derived exosomes ameliorate sulfur mustard-induced acute lung injury by regulating the GPRC5A–YAP axis24
MicroRNAs are involved in the development and progression of gastric cancer24
Surface loading of nanoparticles on engineered or natural erythrocytes for prolonged circulation time: strategies and applications23
Methylene blue ameliorates brain edema in rats with experimental ischemic stroke via inhibiting aquaporin 4 expression23
Ruscogenin attenuates particulate matter-induced acute lung injury in mice via protecting pulmonary endothelial barrier and inhibiting TLR4 signaling pathway23
Direct cardio-protection of Dapagliflozin against obesity-related cardiomyopathy via NHE1/MAPK signaling23
Fisetin alleviates sepsis-induced multiple organ dysfunction in mice via inhibiting p38 MAPK/MK2 signaling23
Novel CDK9 inhibitor oroxylin A promotes wild-type P53 stability and prevents hepatocellular carcinoma progression by disrupting both MDM2 and SIRT1 signaling23
Triptolide suppresses the growth and metastasis of non-small cell lung cancer by inhibiting β-catenin-mediated epithelial–mesenchymal transition23
A simple, quick, and efficient CRISPR/Cas9 genome editing method for human induced pluripotent stem cells23
Intrarenal 1-methoxypyrene, an aryl hydrocarbon receptor agonist, mediates progressive tubulointerstitial fibrosis in mice23
Activation of GPR120 in podocytes ameliorates kidney fibrosis and inflammation in diabetic nephropathy22
Interleukin-17 upregulation participates in the pathogenesis of heart failure in mice via NF-κB-dependent suppression of SERCA2a and Cav1.2 expression22
Pristimerin protects against inflammation and metabolic disorder in mice through inhibition of NLRP3 inflammasome activation22
Updates on novel pharmacotherapeutics for the treatment of nonalcoholic steatohepatitis22
DL0410 ameliorates cognitive disorder in SAMP8 mice by promoting mitochondrial dynamics and the NMDAR-CREB-BDNF pathway22
Bmal1 inhibits phenotypic transformation of hepatic stellate cells in liver fibrosis via IDH1/α-KG-mediated glycolysis22
Ginsenoside Rb1 alleviates colitis in mice via activation of endoplasmic reticulum-resident E3 ubiquitin ligase Hrd1 signaling pathway22
TRIM25 activates AKT/mTOR by inhibiting PTEN via K63-linked polyubiquitination in non-small cell lung cancer22
Metrnl deficiency decreases blood HDL cholesterol and increases blood triglyceride22
Multi-compound and drug-combination pharmacokinetic research on Chinese herbal medicines22
Betulinic acid hydroxamate prevents colonic inflammation and fibrosis in murine models of inflammatory bowel disease21
Targeted inhibition of calpain in mitochondria alleviates oxidative stress-induced myocardial injury21
Trilobatin rescues cognitive impairment of Alzheimer’s disease by targeting HMGB1 through mediating SIRT3/SOD2 signaling pathway21
Ginsenoside Rg1 exerts neuroprotective effects in 3-nitropronpionic acid-induced mouse model of Huntington’s disease via suppressing MAPKs and NF-κB pathways in the striatum21
Gut microbiota in pancreatic diseases: possible new therapeutic strategies21
Caffeine promotes angiogenesis through modulating endothelial mitochondrial dynamics21
Sorafenib triggers ferroptosis via inhibition of HBXIP/SCD axis in hepatocellular carcinoma21
Methylene blue prevents osteoarthritis progression and relieves pain in rats via upregulation of Nrf2/PRDX121
Artemisinin improves neurocognitive deficits associated with sepsis by activating the AMPK axis in microglia21
Dipeptidyl peptidase 4 inhibitor sitagliptin protected against dextran sulfate sodium-induced experimental colitis by potentiating the action of GLP-221
Post-translational modification of KRAS: potential targets for cancer therapy20
Pharmacokinetics-based identification of pseudoaldosterogenic compounds originating from Glycyrrhiza uralensis roots (Gancao) after dosing LianhuaQingwen capsule20
Mesenchymal stem cells in fibrotic diseases—the two sides of the same coin20
GJA1-20k attenuates Ang II-induced pathological cardiac hypertrophy by regulating gap junction formation and mitochondrial function20
Zonisamide, an antiepileptic drug, alleviates diabetic cardiomyopathy by inhibiting endoplasmic reticulum stress20
Pharmacologically inhibiting phosphoglycerate kinase 1 for glioma with NG5220
Mzb1 protects against myocardial infarction injury in mice via modulating mitochondrial function and alleviating inflammation20
Anti-PD-L1 mediating tumor-targeted codelivery of liposomal irinotecan/JQ1 for chemo-immunotherapy20
Bergenin, a PPARγ agonist, inhibits Th17 differentiation and subsequent neutrophilic asthma by preventing GLS1-dependent glutaminolysis20
PRMT5 confers lipid metabolism reprogramming, tumour growth and metastasis depending on the SIRT7-mediated desuccinylation of PRMT5 K387 in tumours20
Sodium propionate exerts anticancer effect in mice bearing breast cancer cell xenograft by regulating JAK2/STAT3/ROS/p38 MAPK signaling20
Anti-inflammatory signaling through G protein-coupled receptors20
Druggability of lipid metabolism modulation against renal fibrosis19
Neuronal chemokine-like-factor 1 (CKLF1) up-regulation promotes M1 polarization of microglia in rat brain after stroke19
Nanomedicine-mediated alteration of the pharmacokinetic profile of small molecule cancer immunotherapeutics19
ZEB1 serves an oncogenic role in the tumourigenesis of HCC by promoting cell proliferation, migration, and inhibiting apoptosis via Wnt/β-catenin signaling pathway19
Inhibition of miR-135a-5p attenuates vascular smooth muscle cell proliferation and vascular remodeling in hypertensive rats19
Pantoprazole ameliorates liver fibrosis and suppresses hepatic stellate cell activation in bile duct ligation rats by promoting YAP degradation19
WNK-SPAK/OSR1-NCC kinase signaling pathway as a novel target for the treatment of salt-sensitive hypertension19
DrugRep: an automatic virtual screening server for drug repurposing19
Cepharanthine sensitizes human triple negative breast cancer cells to chemotherapeutic agent epirubicin via inducing cofilin oxidation-mediated mitochondrial fission and apoptosis19
Reversal of the immunosuppressive tumor microenvironment by nanoparticle-based activation of immune-associated cells18
Pharmacological and cardiovascular perspectives on the treatment of COVID-19 with chloroquine derivatives18
RIP1 promotes proliferation through G2/M checkpoint progression and mediates cisplatin-induced apoptosis and necroptosis in human ovarian cancer cells18
A novel Diels–Alder adduct of mulberry leaves exerts anticancer effect through autophagy-mediated cell death18
FXR: structures, biology, and drug development for NASH and fibrosis diseases18
Feasibility study of 68Ga-labeled CAR T cells for in vivo tracking using micro-positron emission tomography imaging18
Ginsenoside Rg1 in neurological diseases: From bench to bedside18
CDER167, a dual inhibitor of URAT1 and GLUT9, is a novel and potent uricosuric candidate for the treatment of hyperuricemia18
Kanglexin delays heart aging by promoting mitophagy18
Hepatocyte-derived VEGFA accelerates the progression of non-alcoholic fatty liver disease to hepatocellular carcinoma via activating hepatic stellate cells17
Sulforaphane activates anti-inflammatory microglia, modulating stress resilience associated with BDNF transcription17
Asiatic acid alleviates ischemic myocardial injury in mice by modulating mitophagy- and glycophagy-based energy metabolism17
Integrative phosphatidylcholine metabolism through phospholipase A2 in rats with chronic kidney disease17
DCZ5248, a novel dual inhibitor of Hsp90 and autophagy, exerts antitumor activity against colon cancer17
Engineered nanomedicines block the PD-1/PD-L1 axis for potentiated cancer immunotherapy17
Osimertinib successfully combats EGFR-negative glioblastoma cells by inhibiting the MAPK pathway17
Predictive biomarkers of immunotherapy response with pharmacological applications in solid tumors17
TFEB, a master regulator of autophagy and biogenesis, unexpectedly promotes apoptosis in response to the cyclopentenone prostaglandin 15d-PGJ217
Roxithromycin attenuates bleomycin-induced pulmonary fibrosis by targeting senescent cells17
A GLP-1 analog lowers ER stress and enhances protein folding to ameliorate homocysteine-induced endothelial dysfunction17
NADPH is superior to NADH or edaravone in ameliorating metabolic disturbance and brain injury in ischemic stroke17
The C terminus of DJ-1 determines its homodimerization, MGO detoxification activity and suppression of ferroptosis17
Melittin ameliorates inflammation in mouse acute liver failure via inhibition of PKM2-mediated Warburg effect17
Apolipoprotein C1 promotes glioblastoma tumorigenesis by reducing KEAP1/NRF2 and CBS-regulated ferroptosis17
A brief guide to good practices in pharmacological experiments: Western blotting17
L-Carnitine protects against tacrolimus-induced renal injury by attenuating programmed cell death via PI3K/AKT/PTEN signaling17
Pramipexole inhibits astrocytic NLRP3 inflammasome activation via Drd3-dependent autophagy in a mouse model of Parkinson’s disease17
A novel tricyclic BTK inhibitor suppresses B cell responses and osteoclastic bone erosion in rheumatoid arthritis16
Discovery of SARS-CoV-2-E channel inhibitors as antiviral candidates16
Corynoxine B derivative CB6 prevents Parkinsonian toxicity in mice by inducing PIK3C3 complex-dependent autophagy16
Wu-5, a novel USP10 inhibitor, enhances crenolanib-induced FLT3-ITD-positive AML cell death via inhibiting FLT3 and AMPK pathways16
The impact of cannabinoid type 2 receptors (CB2Rs) in neuroprotection against neurological disorders16
Chromatin accessibility analysis reveals that TFAP2A promotes angiogenesis in acquired resistance to anlotinib in lung cancer cells16
MicroRNA-214 contributes to Ang II-induced cardiac hypertrophy by targeting SIRT3 to provoke mitochondrial malfunction16
Ganoderic acid alleviates chemotherapy-induced fatigue in mice bearing colon tumor16
1,2,4-Trimethoxybenzene selectively inhibits NLRP3 inflammasome activation and attenuates experimental autoimmune encephalomyelitis16
Inhibition of histamine receptor H3 suppresses the growth and metastasis of human non-small cell lung cancer cells via inhibiting PI3K/Akt/mTOR and MEK/ERK signaling pathways and blocking EMT16
Fatty acid-binding protein 7 triggers α-synuclein oligomerization in glial cells and oligodendrocytes associated with oxidative stress16
Activating α7nAChR ameliorates abdominal aortic aneurysm through inhibiting pyroptosis mediated by NLRP3 inflammasome16
Development of a nanobody-based immunoassay for the sensitive detection of fibrinogen-like protein 116
Blockage of sphingosine-1-phosphate receptor 2 attenuates 2,4-dinitrochlorobenzene-induced atopic dermatitis in mice16
Lupeol protects against cardiac hypertrophy via TLR4-PI3K-Akt-NF-κB pathways16
G3BP1 promotes human breast cancer cell proliferation through coordinating with GSK-3β and stabilizing β-catenin16
10,11-dehydrocurvularin exerts antitumor effect against human breast cancer by suppressing STAT3 activation16
Extracellular vesicles in vascular remodeling16
0.049640893936157