Science China-Life Sciences

Article	Citations
What the genome of the leafy seadragon teaches us about rapid evolution of camouflage and adaptations to life in the kelp forest	268
Whole-exome sequencing reveals genetic risks of early-onset sporadic dilated cardiomyopathy in the Chinese Han population	219
Unraveling the origins of PGY-sRNA-6, BZL-sRNA-20, and XKC-sRNA-h3	185
Convergent and conserved roads lead to Rome: now archaea fill the gap of transcription termination	151
Comprehensive cultivation of the broiler gut microbiota guides bacterial isolation from chickens	139
Identification of EPOR and JAK2 double heterozygous variants in twin cases with familial erythrocytosis	114
m6A reader YTHDF2 governs the onset of atrial fibrillation by modulating Cacna1c translation	99
Strategic codon selection for enhanced genetic code expansion	95
Enlarged fins of Tibetan catfish provide new evidence of adaptation to high plateau	88
The oligosaccharyltransferase subunit PsSTT3A regulates N-glycosylation and is critical for development and virulence of Phytophthora sojae	87
Where the hope grows: strategies to fight cancer in China	81
Profile of Dr. Chen Dong	77
Expression of phenylalanine ammonia lyase as an intracellularly free and extracellularly cell surface-immobilized enzyme on a gut microbe as a live biotherapeutic for phenylketonuria	76
PCAF-mediated acetylation of METTL3 impairs mRNA translation efficiency in response to oxidative stress	76
Artificial enzymes: learning from nature and beyond	68
Selenium-enriched Cardamine violifolia protects against sepsis-induced intestinal injury by regulating mitochondrial fusion in weaned pigs	66
Tangled but ordered human mitochondrial tRNA maturation	66
Dietary carbohydrate intake and risk of type 2 diabetes: a 16-year prospective cohort study	65
Systematical identification of regulatory GPCRs by single-cell trajectory inference reveals the role of ADGRD1 and GPR39 in adipogenesis	56
Harnessing the Streptomyces-originating type I-E CRISPR/Cas system for efficient genome editing in Streptomyces	56
Prevalence of malnutrition among adult inpatients in China: a nationwide cross-sectional study	52
Profile of Dr. Jiaojun Zhu	50
Synergistic effects of mTOR inhibitors with VEGFR3 inhibitors on the interaction between TSC2-mutated cells and lymphatic endothelial cells	48
Clinical biomarkers of perioperative neurocognitive disorder: initiation and recommendation	45
BEND3 takes the rein	44

Unraveling the stereoscopic gene transcriptional landscape of zebrafish using FishSED, a fish spatial expression database with multispecies scalability	44
Multi-omics analysis of attenuated variant reveals potential evaluation marker of host damaging for SARS-CoV-2 variants	44
Microbe-induced gene silencing explores interspecies RNAi and opens up possibilities of crop protection	43
SUB1 promotes colorectal cancer metastasis by activating NF-κB signaling via UBR5-mediated ubiquitination of UBXN1	42
Cutting the Gordian knot of plant genetics: retrieval of missing heritability in tomato	41
Paracrine function amplifies pro-tumor electrochemical signal within neuron-glioma synapses	41
Longitudinal virological changes and underlying pathogenesis in hospitalized COVID-19 patients in Guangzhou, China	38
Mechanical transmission enables EMT cancer cells to drive epithelial cancer cell migration to guide tumor spheroid disaggregation	38
Applications and grants of National Natural Science Foundation of China’s General Program in cardiovascular research: a 10-year review	37
CREB1 contributes colorectal cancer cell plasticity by regulating lncRNA CCAT1 and NF-κB pathways	36
Lysosomal cholesterol accumulation is commonly found in most peroxisomal disorders and reversed by 2-hydroxypropyl-β-cyclodextrin	35
Potential oligonucleotide drugs in Bencao sRNA Atlas	35
Exploring the role of autophagy during early human embryonic development through single-cell transcriptome and methylome analyses	35
OsDREB1C, an integrator for photosynthesis, nitrogen use efficiency, and early flowering	35
The relative and combined effects of herbivore assemblage and soil nitrogen on plant diversity	34
Profile of Prof. Ke-Qin Zhang	34
Light exposure during early life promotes learning in adulthood	33
Quantitative characterization of filamentous fungal promoters on a single-cell resolution to discover cryptic natural products	33
Profile of Dr. Jianxin Jiang	33
C1M2: a universal algorithm for 3D instance segmentation, annotation, and quantification of irregular cells	32
Loss of Tet hydroxymethylase activity causes mouse embryonic stem cell differentiation bias and developmental defects	32
New insights from a plant immune receptor may help design of disease resistant crops	31
ZP2: the precision regulator of egg coat architecture during fertilization	31
Identification of a von Willebrand factor type A protein affecting both grain and flag leaf morphologies in wheat	31
The recombinant jasmonate ZIM-domain (JAZ) protein functions as a novel insecticidal protein against Lepidopteran pests	31
High dimensional proteomic mapping of bone marrow immune characteristics in immune thrombocytopenia	30
The genetic basis and process of inbreeding depression in an elite hybrid rice	29
Metal ion metabolism and osteoporosis: possible implications for pharmaceutical biotechnology and tissue engineering	29
Circular RNA circCCNB1 inhibits the migration and invasion of nasopharyngeal carcinoma through binding and stabilizing TJP1 mRNA	28
Green innovation for green light	28
RNA ac4C modification in cancer biology: from regulatory mechanisms to clinical applications	28
B cell development and antibody responses in human immune system mice: current status and future perspective	28
Mechanisms of chromatin-based epigenetic inheritance	28
CHIT1-positive microglia act as culprits for spinal motor neuron aging	28
A twist in the tale: global insights into archaeal box C/D RNA-guided 2′-O-methylation	28
Discovery of potential anti-SARS-CoV-2 drugs based on large-scale screening in vitro and effect evaluation in vivo	28
miR319-TCPs-TGA9/TGA10/ROXY2 regulatory module controls cell fate specification in early anther development in Arabidopsis	28
Inhibition of KDM6B prevents osteoarthritis by blocking growth plate-like H3K27me3 loss in bivalent genes	28
Understanding the “SMART” features of hematopoietic stem cells and beyond	27
Integration of CRISPR screening and proteomic analysis of WDR91 manipulation of endosome-to-cytosol transport of African swine fever virus	27
Single-cell transcriptomics of immune cells in lymph nodes reveals their composition and alterations in functional dynamics during the early stages of bubonic plague	27
Functional trait space and redundancy of plant communities decrease toward cold temperature at high altitudes in Southwest China	26
An intricate regulation of WblA controlling production of silent tylosin analogues and abolishment of expressible nikkomycin	26
Advances in genotypic antimicrobialresistance testing: a comprehensive review	26
Reconstruction characteristics of gut microbiota from patients with type 1 diabetes affect the phenotypic reproducibility of glucose metabolism in mice	25
Lipid nanoparticle-mediated base-editing of the Hao1 gene achieves sustainable primary hyperoxaluria type 1 therapy in rats	25
Dissecting the cell microenvironment of ovarian endometrioma through single-cell RNA sequencing	25
Approach from the laboratory to the field: New strategies in the control of mosquito-borne infectious diseases	25
Metatranscriptomic analysis of host response and vaginal microbiome of patients with severe COVID-19	24
Pseudo-chromosome—length genome assembly for a deep-sea eel Ilyophis brunneus sheds light on the deep-sea adaptation	24

rAAV-CRISPR/Cas9-mediated in vivo delivery of porcine embryos to construct knockout pigs	24
Individual and joint exposures to PM2.5 constituents and mortality risk among the oldest-old in China	23
G9a/GLP catalyzes H3K14me1 and H3K14me2 in vivo and in vitro	23
Genome editing technology and medical applications	23
Profile of Chao Liu	23
Genomic insights into versatile lifestyle of three new bacterial candidate phyla	23
The immuno-metabolic trade-off: a driver of metabolic disorders and aging	22
Emergence of a novel reassortant avian influenza virus (H10N3) in Eastern China with high pathogenicity and respiratory droplet transmissibility to mammals	22
Causal relationships between chronotype and risk of multiple cancers by using longitudinal data and Mendelian randomization analysis	22
Evolution of sexual dimorphism in nonhuman primates	22
Spatiotemporal transcriptomics unveil gelsolin as a critical regulator in ventricular remodeling after myocardial infarction	22
Mechanism studies of the activation of DNA methyltransferase DNMT1 triggered by histone H3 ubiquitination, revealed by multi-scale molecular dynamics simulations	22
Signpost in the maze: high-quality genome of drought-resistant maize germplasm released	22
Trash to treasure: lactate and protein lactylation in maize root impacts response to drought	22
Genetic lineage tracing identifies cardiac mesenchymal-to-adipose transition in an arrhythmogenic cardiomyopathy model	21
PanGu Drug Model: learn a molecule like a human	21
Dynamic changes in butyrate levels regulate satellite cell homeostasis by preventing spontaneous activation during aging	21
Enhancing whole yeast genome rearrangements through multiple LoxPsym sequences	20
Short telomeres impede germ cell specification by upregulating MAPK and TGFβ signaling	20
Characterization of Photorhabdus Virulence Cassette as a causative agent in the emerging pathogen Photorhabdus asymbiotica	20
Cortisol safeguards oogenesis by promoting follicular cell survival	20
Cytokines-activated nuclear IKKα-FAT10 pathway induces breast cancer tamoxifen-resistance	19
Identification of LRRC46 as a novel candidate gene for high myopia	19
Loop CD20/CD19 CAR-T cells eradicate B-cell malignancies efficiently	19
TIP60 acetylation of Bub1 regulates centromeric H2AT120 phosphorylation for faithful chromosome segregation	19
Enzyme-mediated proximity labeling for mapping molecular interactions	19
Mutations in wheat TaAPA2 gene result in pleiotropic effects on plant architecture	19
COVID-19 vaccine updates for people under different conditions	19
TBC1D1 is an energy-responsive polarization regulator of macrophages via governing ROS production in obesity	19
Blood group-gut microbiome—health axis gains further support from landmark multi-omics study in swines	19
Effector Immune Cell Deployment: a revolutionized concept in cancer immunotherapy	19
Whole-genome sequencing identifies novel genes for autism in Chinese trios	18
Unveiling potential sex-determining genes and sex-specific markers in autotetraploid Carassius auratus	18
Masting promotes transformation from predation to mutualism in an oak-weevil-rodent system	18
Nanowire-mediated miRNA delivery	18
Vibration mechanics involved in buzz pollination lead to size-dependent associations between bumblebees and Pedicularis flowers	17
Erratum to: Generating broad-spectrum tolerance to ALS-inhibiting herbicides in rice by base editing	17
Directed yeast genome evolution by controlled introduction of trans-chromosomic structural variations	17
Structure of a histone hexamer bound by the chaperone domains of SPT16 and MCM2	17
Erratum to: MYH7B variants cause hypertrophic cardiomyopathy by activating the CaMK-signaling pathway	17
Hidden allies: the role of gut microbes in carcinogen-driven cancer	17
Ferrodifferentiation regulates neurodevelopment via ROS generation	17
Gut microbial interactions based on network construction and bacterial pairwise cultivation	16
Short-term exposure to fine particulate matter constituents and mortality: case-crossover evidence from 32 counties in China	16
Translocation of gut microbes to epididymal white adipose tissue drives lipid metabolism disorder under heat stress	16
New loci for refractive errors and ocular biometric parameters in young Chinese Han adults	16
Hemin blocks TIGIT/PVR interaction and induces ferroptosis to elicit synergistic effects of cancer immunotherapy	16
Plant synthetic epigenomic engineering for crop improvement	16
Targeted DNA demethylation produces heritable epialleles in rice	16
Expanding Asgard members in the domain of Archaea sheds new light on the origin of eukaryotes	16
Overview of SARS-CoV-2 genome-encoded proteins	16
MS1 is essential for male fertility by regulating the microsporocyte cell plate expansion in soybean	16
AAV-mediated gene therapies by miniature gene editing tools	15
αExtractor: a system for automatic extraction of chemical information from biomedical literature	15
A 5′ tRNA-Ala-derived small RNA regulates anti-fungal defense in plants	15
Extensive sequence divergence between the reference genomes of Taraxacum kok-saghyz and Taraxacum mongolicum	15
CRISPR-CasRx knock-in mice for RNA degradation	15
Cancer metabolism and tumor microenvironment: fostering each other?	15
An in-depth understanding of the role and mechanisms of T cells in immune organ aging and age-related diseases	15
Cracking the chitin code: how a single pair of LysM receptors deciphers symbiosis and immunity in Marchantia	15
Towards high-density storage of text and images into DNA by the “Xiao-Pang” codec system	15
Yield and quality properties of silage maize and their influencing factors in China	15
Ultrasound-induced biophysical effects in controlled drug delivery	14
LncFASA promotes cancer ferroptosis via modulating PRDX1 phase separation	14
Overview and countermeasures of cancer burden in China	14
A pan-coronavirus peptide inhibitor prevents SARS-CoV-2 infection in mice by intranasal delivery	14
Movie therapy for children with amblyopia: restoring binocular vision with brain plasticity	14
Genome-wide CRISPR screens identify CLC-2 as a drug target for anti-herpesvirus therapy: tackling herpesvirus drug resistance	14
Green manuring relocates microbiomes in driving the soil functionality of nitrogen cycling to obtain preferable grain yields in thirty years	14
Trace metal elements: a bridge between host and intestinal microorganisms	14
Analyzing the cellular and molecular atlas of ovarian mesenchymal cells provides a strategy against female reproductive aging	14
Octahedral silver oxide nanoparticles enabling remarkable SERS activity for detecting circulating tumor cells	14
Whole-genome sequencing in medicinal plants: current progress and prospect	14
A shared role of the myocardin-family transcriptional coactivators in cardiomyocyte maturation	13
A novel deacetylase inhibitor KLX suppresses liver fibrosis by deacetylating PPARγ through promoting ubiquitination-mediated HDAC1 degradation	13
Terrestrial carbon sinks in China and around the world and their contribution to carbon neutrality	13
Plant and fungal species interactions differ between aboveground and belowground habitats in mountain forests of eastern China	13
Gut microbiota bridges dietary nutrients and host immunity	13
An imputed whole-genome sequence-based GWAS approach pinpoints causal mutations for complex traits in a specific swine population	13
Ser68 phosphoregulation is essential for CENP-A deposition, centromere function and viability in mice	13

RNA modifications in the progression of liver diseases: from fatty liver to cancer	13
Ononin inhibits triple-negative breast cancer lung metastasis by targeting the EGFR-mediated PI3K/Akt/mTOR pathway	13
Conservation medicine: a “Unity of Nature and Man” perspective	13
Distant cousins come to ABP1’s rescue	13
Reevaluation by the CRISPR/Cas9 knockout approach revealed that multiple pluripotency-associated lncRNAs are dispensable for pluripotency maintenance while Snora73a/b is essential for pluripotency exi	12
An effective pharmacological hydrogel induces optic nerve repair and improves visual function	12
Biogenesis, action and biological functions of an Arabidopsis 5′ tRF, 5′ tsR-Ala	12
Spraying compound probiotics improves growth performance and immunity and modulates gut microbiota and blood metabolites of suckling piglets	12
sRNAminer, a swiss army knife in small RNA research	12
Dynamic WNT signaling controls differentiation of hematopoietic progenitor cells from human pluripotent stem cells	12
Isowalsuranolide targets TrxR1/2 and triggers lysosomal biogenesis and autophagy via the p53-TFEB/TFE3 axis	12
Burch colposuspension for stress urinary incontinence: a 14-year prospective follow-up	12
Current status and impact of the Young Scientist Foundation of the National Natural Science Foundation on Chinese young scholars in cardiovascular research	12
Low-affinity SPL binding sites contribute to subgenome expression divergence in allohexaploid wheat	12
PKC-SWI6 signaling regulates asexual development, cell wall integrity, stress response, and lifestyle transition in the nematode-trapping fungus Arthrobotrys oligospora	12
An endogenous neuropeptide hormone assists cancer cells in escaping from immune surveillance	12
Reverse spillover of SARS-CoV-2 from human to wild animals	11
The p38/MAPK pathway as a therapeutic target to prevent therapeutic escape of breast cancer stem cells	11
Gene editing: from technologies to applications in research and beyond	11
Conversion therapy of intermediate and advanced hepatocellular carcinoma using superstable homogeneous iodinated formulation technology	11
A neuropsin-based optogenetic tool for precise control of Gq signaling	11
Prioritization of risk genes in colorectal cancer by integrative analysis of multi-omics data and gene networks	11
QNE1 is a key flowering regulator determining the length of the vegetative period in soybean cultivars	11
The role and potential application of extracellular vesicles in liver cancer	11
FSIP1 enhances the therapeutic sensitivity to CDK4/6 inhibitors in triple-negative breast cancer patients by activating the Nanog pathway	11
Shifts in reproductive strategies in the evolutionary trajectory of plant lineages	10
Integrated neural tracing and in-situ barcoded sequencing reveals the logic of SCN efferent circuits in regulating circadian behaviors	10
Transformation of cognition from mechanical to biological aqueous outflow pump may be a breakthrough in solving the problem of intraocular pressure regulation in glaucoma	10
Enlarged DNA unwinding by Nme2Cas9 permits a broadened base editing window beyond the protospacer	10
Autoinhibition and cofactors of a helper NLR	10
FHL2 deficiency aggravates Candida albicans infection through decreased myelopoiesis	10
Temperature driven antagonistic fate determination by two bHLH transcription factors: dormancy or germination	10
Precise editing of methylated cytosine in Arabidopsis thaliana using a human APOBEC3Bctd-Cas9 fusion	10
Preface to the special topic on tissue stem cell research	10
A noncoding secret to stay young—protecting Treg cells to keep the balance in the liver	10
Elucidation of the neutralizing antibody evasion of emergent SARS-CoV-2 Omicron sub-lineages using structural analysis	10
Innovative genome editing in plants: a transposase and CRISPR combination approach	10
Whole grain black rice: a paradigm shift from mainly calories to a nutritious food that benefits human health	10
Bioactive materials from berberine-treated human bone marrow mesenchymal stem cells promote alveolar bone regeneration by regulating macrophage polarization	10
Degeneration of foundation cushion species induced by ecological constraints can cause massive changes in alpine plant communities	10
Nematode-induced trap formation regulated by the histone H3K4 methyltransferase AoSET1 in the nematode-trapping fungus Arthrobotrys oligospora	10
All types of base conversions allowed by base editors	10
Profile of Dr. Qian Qian	10
SETD3-mediated histidine methylation of MCM7 regulates DNA replication by facilitating chromatin loading of MCM	10
Plant diversity increases diversity and network complexity rather than alters community assembly processes of leaf-associated fungi in a subtropical forest	10
Lifetime probabilities of developing and dying from cancer in China: comparison with Japan and the United States in 2022	10
Osmosensor TMEM63B facilitates insulin secretion in pancreatic β-cells	10
Mobile ARGONAUTE 1d binds 22-nt miRNAs to generate phasiRNAs important for low-temperature male fertility in rice	9
Effector modularity promotes functional diversification and evolutionary processes	9
Applications and grants of the National Natural Science Foundation of China’s General Program and Young Scientists Fund in immunology research: a 10-year review (2013–2022)	9
Precision regulation of plant aromatic amino acid homeostasis	9
Exploring the potential of extrachromosomal DNA as a novel oncogenic driver	9
Integration of perioperative features and intragraft TCF7L2 expression to predict lipid metabolic disorder in liver transplant recipients	9
MSC-mediated mitochondrial transfer restores mitochondrial DNA and function in neural progenitor cells of Leber’s hereditary optic neuropathy	9
Machine learning-aided scoring of synthesis difficulties for designer chromosomes	9
Disruption of PABPN1 phase separation by SNRPD2 drives colorectal cancer cell proliferation and migration through promoting alternative polyadenylation of CTNNBIP1	9
Human TRMT1 catalyzes m2G or m22G formation on tRNAs in a substrate-dependent manner	9
Recent progress on mechanisms of human cognition and brain disorders	9
Engineering biomimetic nanosystem targeting multiple tumor radioresistance hallmarks for enhanced radiotherapy	9
A neural m6A pathway regulates behavioral aggregation in migratory locusts	9
Ferroptosis: a critical mechanism of N6-methyladenosine modification involved in carcinogenesis and tumor progression	9
Nitrogen addition promotes soil carbon accumulation globally	9
Cellular atlases of ovarian microenvironment alterations by diet and genetically-induced obesity	9
Efficacy and safety of transvaginal mesh repair in a cohort with a minimum of 10-year follow-up	9
Interplant communication: an emerging battlefield in plant-aphid-virus interactions	9
Transient receptor potential vanilloid-1 (TRPV1) is a mediator of noise-induced neural damage in zebrafish and mice	9
Reversing anther thermotolerance by manipulating the cis-elements in the promoter of a high-temperature upregulated gene Casein Kinase I in upland cotton	9
Pathogen-associated T follicular helper cell plasticity is critical in anti-viral immunity	9
Phenotypic and genetic characterization of novel variant in the NF1 gene underlying neurofibromatosis type 1 in five Chinese families	9
Longitudinal gut fungal alterations and potential fungal biomarkers for the progression of primary liver disease	9
The single-cell transcriptomic landscape of the topological differences in mammalian auditory receptors	9
Resolving the developmental mechanisms of cardiac microthrombosis of SARS-CoV-2 based on single-cell transcriptome analysis	9
Targeting the ECM component HA: a new route for mCRC treatment	9
Characterization of whole genomes from recently emerging Mpox cases in several regions of China, 2023	9
NAD+-capped RNAs are widespread in rice (Oryza sativa) and spatiotemporally modulated during development	9
Sex determination mechanisms and sex control approaches in aquaculture animals	9
Local field potentials, spiking activity, and receptive fields in human visual cortex	8
Recent advances in RNA structurome	8
Retinal microvasculature is a potential biomarker for acute mountain sickness	8
A human-specific insertion promotes cell proliferation and migration by enhancing TBC1D8B expression	8
Low-density lipoprotein receptor-related protein 1 is a CROPs-associated receptor for Clostridioides infection toxin B	8
Redox-stress response resistance (RRR) mediated by hyperoxidation of peroxiredoxin 2 in senescent cells	8
Viromes in marine ecosystems reveal remarkable invertebrate RNA virus diversity	8
DENND1A desensitizes granulosa cells to FSH by arresting intracellular FSHR transportation	8
Effect of SARS-CoV-2 infection in early pregnancy on placental development	8
Genetically encoded redox biosensor system for H2O2 measurement in four subcellular compartments in acute myeloid leukemia (AML) cells	8
Decoding the intracellular trafficking rule for circular RNAs	8
An overview of detecting gene-trait associations by integrating GWAS summary statistics and eQTLs	8
Spatial-temporal population dynamics of the critically endangered Blue-crowned Laughingthrush Pterorhinus courtoisi: a 22-year longitudinal study	8
Cancer challenges worldwide and in China: preparing for the inevitable	8
A human antibody potently neutralizes RSV by targeting the conserved hydrophobic region of prefusion F	8
On the origin of SARS-CoV-2—The blind watchmaker argument	8
Dogs lacking Apolipoprotein E show advanced atherosclerosis leading to apparent clinical complications	8
NPC1-regulated dynamic of clathrin-coated pits is essential for viral entry	8
The genomic and immunogenomic landscape of mechanics pathway informs clinical prognosis and response to mechanotherapy	8