Science China-Life Sciences

Article	Citations
What the genome of the leafy seadragon teaches us about rapid evolution of camouflage and adaptations to life in the kelp forest	353
New insights from a plant immune receptor may help design of disease resistant crops	334
Nanowire-mediated miRNA delivery	188
Inhibition of KDM6B prevents osteoarthritis by blocking growth plate-like H3K27me3 loss in bivalent genes	161
Chemical adaptation: bridging synthetic chemistry with drug development	159
Dietary carbohydrate intake and risk of type 2 diabetes: a 16-year prospective cohort study	148
Toward a comprehensive map of Rab-mediated cargo transport to migrasomes	139
Convergent and conserved roads lead to Rome: now archaea fill the gap of transcription termination	135
Dissecting the cell microenvironment of ovarian endometrioma through single-cell RNA sequencing	133
m6A reader YTHDF2 governs the onset of atrial fibrillation by modulating Cacna1c translation	128
Pseudo-chromosome—length genome assembly for a deep-sea eel Ilyophis brunneus sheds light on the deep-sea adaptation	106
Cytokines-activated nuclear IKKα-FAT10 pathway induces breast cancer tamoxifen-resistance	100
Genetic mutations across multiple pathways drive filamentous growth and virulence in the emerging fungal pathogen Candida auris	100
Vibration mechanics involved in buzz pollination lead to size-dependent associations between bumblebees and Pedicularis flowers	96
Enlarged fins of Tibetan catfish provide new evidence of adaptation to high plateau	83
Green manuring relocates microbiomes in driving the soil functionality of nitrogen cycling to obtain preferable grain yields in thirty years	73
Unveiling potential sex-determining genes and sex-specific markers in autotetraploid Carassius auratus	69
RNA ac4C modification in cancer biology: from regulatory mechanisms to clinical applications	64
The genetic basis and process of inbreeding depression in an elite hybrid rice	63
Quantitative characterization of filamentous fungal promoters on a single-cell resolution to discover cryptic natural products	61
Loss of Tet hydroxymethylase activity causes mouse embryonic stem cell differentiation bias and developmental defects	59
Microbe-induced gene silencing explores interspecies RNAi and opens up possibilities of crop protection	57
Danhong Injection targets CaMKII through Dihydrotanshinone I to alleviate cardiomyocyte death and inflammation in viral myocarditis	57
TRAD: a functional annotation resource for human tandem repeats	53
Integration of perioperative features and intragraft TCF7L2 expression to predict lipid metabolic disorder in liver transplant recipients	52

Advances in genotypic antimicrobialresistance testing: a comprehensive review	52
A neighboring NLR negatively regulates the wheat broad-spectrum resistance protein encoded by Pm21	52
FHL2 deficiency aggravates Candida albicans infection through decreased myelopoiesis	51
Enlarged DNA unwinding by Nme2Cas9 permits a broadened base editing window beyond the protospacer	51
NAP-seq: unveiling the hidden world of noncapped RNAs	50
Unraveling the diversity of bile acid modifications by integrative mass spectrometry approaches	49
CRISPR screening identifies protein methylation and ubiquitination modifications that modulate aflatoxin B1 cytotoxicity	49
PanSci: decoding panoramas of ageing	48
Attenuation of plant immune kinases by U-box type E3 ubiquitin ligases	46
Interplant communication: an emerging battlefield in plant-aphid-virus interactions	45
Phase separation of a master transcription factor targeted by a natural compound regulates fungal ergosterol homeostasis	44
Nematode-induced trap formation regulated by the histone H3K4 methyltransferase AoSET1 in the nematode-trapping fungus Arthrobotrys oligospora	43
Effect of SARS-CoV-2 infection in early pregnancy on placental development	42
Precision regulation of plant aromatic amino acid homeostasis	41
Nicotinamide prevents anti-PD1 immune checkpoint inhibitor-associated early stages of cardiotoxicity	41
An artificial immune switch system: engineering durable, broad-spectrum disease resistance in plants	40
Systems metabolic engineering of Phaffia rhodozyma for ultra-high astaxanthin production through multiple strategies	40
Plant and fungal species interactions differ between aboveground and belowground habitats in mountain forests of eastern China	40
A shared role of the myocardin-family transcriptional coactivators in cardiomyocyte maturation	40
Multi-omics study reveals a light-dependent regulatory network of flavonoid biosynthesis in lettuce (Lactuca sativa L.)	39
Predicting Lactobacillus delbrueckii subsp. bulgaricus-Streptococcus thermophilus interactions based on a highly accurate semi-supervised learning method	37
Host-microbial co-regulation mediates rumen volatile fatty acid production and utilization in dairy cows	37
Cereal-legume intercropping stimulates straw decomposition and promotes soil organic carbon stability	36
Critical roles of non-coding RNAs in lifecycle and biology of Marek’s disease herpesvirus	36
Secretory NS1’ protein of orthoflavivirus promotes viral transmission to mosquitoes by suppressing the RNAi pathway	36
Human TRMT1 catalyzes m2G or m22G formation on tRNAs in a substrate-dependent manner	36
Integrative analysis based on CRISPR screen identifies apilimod as a potential therapeutic agent for cisplatin-induced acute kidney injury treatment	36
TEDD 2.0: an advanced temporal gene expression database enabled by in-silico functional analyses for developmental mechanism investigation	36
A neural m6A pathway regulates behavioral aggregation in migratory locusts	34
Activating the cGAS-STING pathway in hypoxic microenvironment: blocking ADSL’s ER localization	34
The genomic and immunogenomic landscape of mechanics pathway informs clinical prognosis and response to mechanotherapy	34
Ginsenoside Rb1 inhibits oxidative stress-induced ovarian granulosa cell injury through Akt-FoxO1 interaction	33
Low-affinity SPL binding sites contribute to subgenome expression divergence in allohexaploid wheat	32
HIV encephalopathy is contributed by macrophages and microglia	32
Mobile ARGONAUTE 1d binds 22-nt miRNAs to generate phasiRNAs important for low-temperature male fertility in rice	32
Advances and applications in single-cell and spatial genomics	32
Nitrogen addition promotes soil carbon accumulation globally	32
Explore the nucleolus: unveiling the hidden layer with super-resolution microscopy	31
Antibody-based targeted protein degradation for membrane and extracellular proteins: emerging strategies and breakthroughs	31
Altered 3D genome reorganization mediates precocious myeloid differentiation of aged hematopoietic stem cells in inflammation	31
Longitudinal plasma proteomic evidence linking SARS-CoV-2 infection to increased β-amyloid pathology	31
Priming crops for heat stress with prime editing	31
SPHK1 deficiency promotes intestinal homeostasis by ameliorating ER stress-induced gastrointestinal injury during murine graft-versus-host disease	30
Natural polymorphisms of COOL1 contribute to cold tolerance adaptation in maize	30
Animal burrows as critical thermal refuges in the age of climate change	29
Enhancing sheepgrass through genomic exploration and targeted editing	29
The vinculin-β-catenin axis promotes bone formation and repair: an essential prerequisite for the anti-osteoporotic efficacy of sclerostin-neutralizing antibody	29
Analysis of non-coding small RNA similarity/sharing between plant and animal genomes	29
Studying bona fide SARS-CoV-2 biology in a BSL-2 biosafety environment using a split-virus-genome system	29
Redox state of NAD modulates the activation of Na-bicarbonate cotransporter NBCe1-B via IRBIT and L-IRBIT	29

Chemical defense mediates population density-driven on anuran brain size evolution	28
Peripheral blood RNA modifications as a novel diagnostic signature for polycystic ovary syndrome	28
Decoding the fish genome opens a new era in important trait research and molecular breeding in China	28
Upgraded durian genome reveals the role of chromosome reshuffling during ancestral karyotype evolution, lignin biosynthesis regulation, and stress tolerance	28
Cell-specific gene expression plasticity in response to hypoxia promotes high-altitude adaptive evolution	28
Three-dimensional visualization of tip-vesicles in growing pollen tubes by electron tomography	28
Design of a novel chimeric peptide via dual blockade of CD47/SIRPα and PD-1/PD-L1 for cancer immunotherapy	28
Strategies and mechanisms for the enhancement of chimeric antigen receptor T-cell functions	28
WTAP mediated m6A methylation modulates retinal photoreceptor function via facilitating of REEP6, PDE6B and RDH12 translation	27
Protein foundation models: a comprehensive survey	27
Piceatannol enhances Beclin-1 activity to suppress tumor progression and its combination therapy strategy with everolimus in gastric cancer	27
RIVER delivers multimodal gene-directed regulatory interactions across diverse biological contexts with broad application potentials	27
From modeling to therapy: the efficient and precise tools for mitochondrial base editing	27
Versatile plant genome engineering using anti-CRISPR-Cas12a systems	27
Activating translation by phase separation: a novel mechanism for driving spermiogenesis	26
RNA modifications: bridging the gap between molecular mechanisms and clinical applications	26
Gut microbiome and postbiotics: bridging the dietary nutrition and feed efficiency in food-producing animals	25
Lentiviral vectors for gene therapy of α-thalassemia	25
Potential oligonucleotide drugs in Bencao sRNA Atlas (II)	25
Building the Chordata Olfactory Receptor Database using more than 400,000 receptors annotated by Genome2OR	25
PIWI-specific insertion module: a newly identified regulatory element essential for longer piRNAs loading and male fertility	25
In-depth urinary and exosome proteome profiling analysis identifies novel biomarkers for diabetic kidney disease	25
Insulin-like growth factor binding proteins 7 prevents dental pulp-derived mesenchymal stem cell senescence via metabolic downregulation of p21	24
The OsRqc1-OsVms1 module regulates the temperature threshold in thermo-sensitive genic male-sterile rice lines	23
Light-at-night exposure drives myopia via melanopsin signalling	23
Erratum to: A thorough analysis of diabetes research in China from 1995 to 2015: current scenario and future scope	23
A synthetic microbial community used as a bioinoculant can overcome rice production constraints in acid soils	23
Targeting LTA4H facilitates the reshaping of the immune microenvironment mediated by CCL5 and sensitizes ovarian cancer to Cisplatin	23
Gene-knockout by iSTOP enables rapid reproductive disease modeling and phenotyping in germ cells of the founder generation	23
An iron-dependent form of non-canonical ferroptosis induced by labile iron	23
Erratum to: Local administration of liposomal-based Plekhf1 gene therapy attenuates pulmonary fibrosis by modulating macrophage polarization	23
A new model system for cotton indoor genetic and genomic research	22
Nitrogen addition and mowing alter drought resistance and recovery of grassland communities	22
Crop antiviral defense: Past and future perspective	22
Green revolution gene drives adaptation of Arabidopsis to the extremely high altitude	22
A hidden translatome in tumors—the coding lncRNAs	22
Optimized inner ear organoids for efficient hair cell generation and ototoxicity response modeling	22
LncRNA CFAR promotes cardiac fibrosis via the miR-449a-5p/LOXL3/mTOR axis	22
Tree of life and conservation of gymnosperms in China	22
PDGFR kinase inhibitor protects against septic death via regulation of BTLA	22
Whole-grain black rice diet rewires the single-cell transcriptomic landscape of age-related ovarian decline in mice	22
Distinct and shared endothermic strategies in the heat producing tissues of tuna and other teleosts	21
Genetic advancements and future directions in ruminant livestock breeding: from reference genomes to multiomics innovations	21
Overcoming genotypic dependency and bypassing immature embryos in wheat transformation by using morphogenic regulators	21
Hot breath, quick exit: aphids flee mammalian heat via TRPA1	21
Development and performance evaluation of a culture-independent nanopore amplicon-based sequencing method for accurate typing and antimicrobial resistance profiling in Neisseria gonorrhoeae	21
Occurrence and distribution of geminiviruses in China	21
Intra-articular injection of stromal vascular fraction for knee degenerative joint disease: a concise review of preclinical and clinical evidence	21
Distinct roles of H3K27me3 and H3K36me3 in vernalization response, maintenance, and resetting in winter wheat	21
Transient chemical-mediated epigenetic modulation confers unrestricted lineage potential on human primed pluripotent stem cells	21
Identification and validation of key biomarkers and potential therapeutic targets for primary open-angle glaucoma	21
Low-dose exposure to microplastics retards meiotic maturation via HDAC3 insufficiency	20
Ribo-seq provides additional evidence for cytoplasm-translated mitochondrial DNA-encoded ORFs	20
CD146, a therapeutic target involved in cell plasticity	20
Pre-disease State perspective in life & health interdisciplinary research	20
Neural identification of self-emitted vocalizations in the auditory midbrain of behaving bats	19
Deamidation enables pathogenic SMAD6 variants to activate the BMP signaling pathway	19
ESIRA, a novel framework integrating efficacy and safety for evaluating first-line treatments in advanced hepatocellular carcinoma	19
PRC2 primes bivalent genes for transcription induction independent of histone methyltransferase activity	19
Genomic analysis of modern maize inbred lines reveals diversity and selective breeding effects	19
Galacto-oligosaccharides enrich galactosidase-encoded rather than all Lachnospiraceae bacteria to redress abnormal gut microbiota and lipid metabolism in pregnancy	19
CARs: a new approach for the treatment of autoimmune diseases	19
The discovery of tiny RNAs that have crucial roles	19
Integrating spatial transcriptomics and single-nucleus RNA-seq revealed the specific inhibitory effects of TGF-β on intramuscular fat deposition	18
Profile of Dr. Shaorong Gao	18
Compound muscle action potential (CMAP) scan examination of paretic and contralateral muscles reveals motor unit alterations after stroke	18
Comprehensive metabolic profiling uncovers early variation and biomarkers of esophageal squamous cell carcinoma	18
Antithetical impacts of deleterious LRP1B mutations in non-squamous and squamous NSCLCs on predicting benefits from immune checkpoint inhibitor alone or with chemotherapy over chemotherapy alone: retr	18
Zooming on T cells in cancer	18
Low-dose lactate promotes neuroinflammation and induces the side effect of colitis	18
Diversity and connectedness of brine shrimp viruses in global hypersaline ecosystems	18
Nucleolar stress promotes and cooperates with ferroptosis to suppress cancer growth	18
Advances in regulation and function of stearoyl-CoA desaturase 1 in cancer, from bench to bed	18
Multi-omic analysis of the liver-breast axis reveals key hepatic mediators of breast cancer progression	18
Efficient generation of all ESC-derived mice carrying a homozygous lethal mutation through eight-cell embryo injection	18
Rice GWAS-to-Gene uncovers the polygenic basis of traits	18
Rice OsMKK6-OsMPK4 cascade regulates endosperm cellularization via Polycomb Repressive Complex 2	18
Atmospheric humidity regulates same-sex mating in Candida albicans through the trehalose and osmotic signaling pathways	18
Wheat stripe rust resistance gene Yr9, derived from rye, is a CC-NBS-LRR gene in a highly conserved NLR cluster	17
LPS-related muscle loss is associated with the alteration of Bacteroidetes abundance, systemic inflammation, and mitochondrial morphology in a weaned piglet model	17

Cryo-EM structures reveal the dynamic transformation of human alpha-2-macroglobulin working as a protease inhibitor	17
The spatial transcriptomic landscape of human gingiva in health and periodontitis	17
A twist in the tale: global insights into archaeal box C/D RNA-guided 2′-O-methylation	17
Enhancing whole yeast genome rearrangements through multiple LoxPsym sequences	17
Cell-supporting cytoskeletons and phagocytic acquisition of compatible solutes emerge as common strategies for high-salt adaptation in different ciliates	17
m6A modification of plant virus enables host recognition by NMD factors in plants	17
Autophagy mediates a direct synergistic interaction during co-transmission of two distinct arboviruses by insect vectors	17
The effect of SARS-CoV-2 infection on human embryo early development: a multicenter prospective cohort study	17
Developing a robust genome editing tool based on an endogenous type I-B CRISPR-Cas system in Saccharopolyspora spinosa	17
Profile of Dr. Jiaojun Zhu	17
AtLYK4 is the major chitin receptor in Arabidopsis with N-glycosylation and ligand-interacting residues orchestrating chitin perception	17
GLA deficiency causes cardiac hypertrophy via enhanced autophagy	17
Vesicle-mediated intercellular communication	17
A paternal protein facilitates sperm RNA delivery to regulate zygotic development	17
Innate and adaptive immune abnormalities underlying autoimmune diseases: the genetic connections	17
Decoupled responses of soil microbial diversity and ecosystem functions to successive degeneration processes in alpine pioneer community	17
Identification of EPOR and JAK2 double heterozygous variants in twin cases with familial erythrocytosis	17
When smoke meets gut: deciphering the interactions between tobacco smoking and gut microbiota in disease development	17
Structure of a histone hexamer bound by the chaperone domains of SPT16 and MCM2	16
Unraveling the origins of PGY-sRNA-6, BZL-sRNA-20, and XKC-sRNA-h3	16
Strategic codon selection for enhanced genetic code expansion	16
SUB1 promotes colorectal cancer metastasis by activating NF-κB signaling via UBR5-mediated ubiquitination of UBXN1	16
Multifactorial and multiplexed epigenomic profiling of five DNA modifications in plants with mDIP-seq	16
Loop CD20/CD19 CAR-T cells eradicate B-cell malignancies efficiently	16
MtLICK1/2: gatekeepers of symbiosis and immunity in Medicago truncatula	16
Mitophagy activation for jawbone radiation injury therapy via angiogenesis/osteogenesis-active nanozymes	16
Enhancement of in vitro transcribed (IVT) mRNA translation efficiency through engineered poly(A) tails	16
Plant synthetic epigenomic engineering for crop improvement	16
Cracking the chitin code: how a single pair of LysM receptors deciphers symbiosis and immunity in Marchantia	16
TIP60 acetylation of Bub1 regulates centromeric H2AT120 phosphorylation for faithful chromosome segregation	16
Potential oligonucleotide drugs in Bencao sRNA Atlas	16
Evolution of drug classification, target distribution, and introduction of novel antidepressants in China	16
GhDREB1B-GhFAD3-2 module mediates drought tolerance by regulating linolenic acid biosynthesis in cotton	15
Single-nucleus RNA sequencing reveals the underlying roadmap of early gonadal differentiation in teleost	15
From oral structure to molecular evidence: new insights into the evolutionary phylogeny of the ciliate order Sessilida (Protista, Ciliophora), with the establishment of two new families and new contri	15
Sequencing and characterizing human mitochondrial genomes in the biobank-based genomic research paradigm	15
ASCENT: an active transfer learning paradigm for efficient drug-target interaction prediction	15
Morphological and physiological responses to aridity in narrowly- and widely-distributed plant species in drylands	15
Individual and joint exposures to PM2.5 constituents and mortality risk among the oldest-old in China	15
Applications and grants of the National Natural Science Foundation of China’s General Program and Young Scientists Fund in immunology research: a 10-year review (2013–2022)	15
Global multifaceted biodiversity patterns, centers, and conservation needs in angiosperms	15
Crosstalk between brassinosteroid signaling and variable nutrient environments	15
Broad synergistic effects of an AMP with multiple antibiotics against drug-resistant bacteria via multifaceted mechanisms	15
Harnessing the Streptomyces-originating type I-E CRISPR/Cas system for efficient genome editing in Streptomyces	15
Autoinhibition and cofactors of a helper NLR	15
Local field potentials, spiking activity, and receptive fields in human visual cortex	15
Effector modularity promotes functional diversification and evolutionary processes	15
Erratum to: FSIP1 enhances the therapeutic sensitivity to CDK4/6 inhibitors in triple-negative breast cancer patients by activating the Nanog pathway	14
Increased virulence and decreased antimicrobial resistance in Klebsiella pneumoniae in Beijing since 2020: a retrospective molecular epidemiology study	14
Deubiquitinases in liver diseases: from mechanisms to targeted therapy	14
Whole grain black rice: a paradigm shift from mainly calories to a nutritious food that benefits human health	14
Computer-aided engineering of CRISPR-Cas proteins for enhanced human genome editing	14
Negative edge effects on forest carbon stocks in China: an estimate based on inventory data	14
Structural characterization of SARS-CoV-2 dimeric ORF9b reveals potential fold-switching trigger mechanism	14
Distant cousins come to ABP1’s rescue	14
Functional characterization of novel NPRL3 mutations identified in three families with focal epilepsy	14
Cucumber green mottle mosaic virus encodes additional small proteins with specific subcellular localizations and virulence function	14
MYC promotes global transcription in part by controlling P-TEFb complex formation via DNA-binding independent inhibition of CDK9 SUMOylation	14
Biosynthesis of melanin from lignin hydrolysates by metabolically engineered Cupriavidus necator	14
Transformation of cognition from mechanical to biological aqueous outflow pump may be a breakthrough in solving the problem of intraocular pressure regulation in glaucoma	14
Dietary iron regulates intestinal goblet cell function and alleviates Salmonella typhimurium invasion in mice	13
Recent advances in RNA structurome	13
Publisher Correction to: The light and hypoxia induced gene ZmPORB1 determines tocopherol content in the maize kernel	13
Amino acids TORC (talk) to anabolism through uncharged tRNA	13
The repression of oncoprotein SET by the tumor suppressor p53 reveals a p53-SET-PP2A feedback loop for cancer therapy	13
The liver-bone axis: an emerging player in disease pathogenesis and therapeutic intervention	13
Functional cancer-cell-nociceptive neuronal circuits drive gastric tumor progression	13
Transcriptome-wide identification of glycoRNAs by Clier-seq pipeline	13
Prioritization of risk genes in colorectal cancer by integrative analysis of multi-omics data and gene networks	13
Approaching the perfection of natural enzymes: evolution of biomimetic catalytic systems	13
Reversing anther thermotolerance by manipulating the cis-elements in the promoter of a high-temperature upregulated gene Casein Kinase I in upland cotton	13
Dual phosphorylation of DISC1 at Ser58 and Ser713 regulates polarization of cortical neurons via GSK3β	13
Progress and gaps in antimicrobial resistance research within One Health sectors in China: a systematic analysis	13
Dynamic landscape and regulation of m5C methylation in human tissues	13
A strategy for the development of receptor-containing antibodies targeting malaria variant surface antigens	13
SETD3-mediated histidine methylation of MCM7 regulates DNA replication by facilitating chromatin loading of MCM	13
Chromatin accessibility landscape during mammalian preimplantation development	13
Treating incurable non-communicable diseases by targeting iron metabolism and ferroptosis	13
Redox-stress response resistance (RRR) mediated by hyperoxidation of peroxiredoxin 2 in senescent cells	13
DDX21 is a new player in co-transcriptional RNA modification and functions	13
Automatic quantification, grading and five-year prediction of myopic fundus tessellation: a multi-center, longitudinal deep learning study	13
Birth-and-death evolution of ribonuclease 9 genes in Cetartiodactyla	13
Microbial bile acid modifications: current understandings, key problems, and future perspectives	13
Single-nucleus transcriptome profiling of wild boar and domestic pig intestines reveals the spatiotemporal dynamics of immunity and nutrient absorption	12
Exploring primate immune responses to SLA-I/II knockdown pig xenografts in humanized mice and rhesus monkeys	12
Stroma-specific IL-15 coordinates epithelial IL-15Rα to promote intestinal epithelial repair	12
GMNN mutations cause female infertility characterized by preimplantation embryo arrest through regulating DNA re-replication	12
Molecular mechanisms of DNA lesion and repair during antibody somatic hypermutation	12
CassavaMDB: an integrated multi-omics database for functional genomics and molecular breeding in cassava	12
Engineered CLE peptides promote de novo shoot regeneration in Arabidopsis	12
Unraveling phylogenetic conflicts and adaptive evolution in Chiroptera using large-scale mitogenomes and nuclear genes	12
Single-base resolution mapping of 2′-O-methylation sites by an exoribonuclease-enriched chemical method	12
Combined effects of climate and land-use changes on the alpha and beta functional diversities of terrestrial mammals in China	12
Generation of transient totipotent blastomere-like stem cells by short-term high-dose Pladienolide B treatment	12
Targeting senescent cells in aged adipose tissue induced by ovarian cancer with the NF-κB inhibitor quercetin and resveratrol impedes the growth and metastasis of ovarian cancer	12