Science China-Life Sciences

Article	Citations
RNA ac4C modification in cancer biology: from regulatory mechanisms to clinical applications	327
What the genome of the leafy seadragon teaches us about rapid evolution of camouflage and adaptations to life in the kelp forest	325
New insights from a plant immune receptor may help design of disease resistant crops	296
Unveiling potential sex-determining genes and sex-specific markers in autotetraploid Carassius auratus	168
Toward a comprehensive map of Rab-mediated cargo transport to migrasomes	142
Nanowire-mediated miRNA delivery	142
Metatranscriptomic analysis of host response and vaginal microbiome of patients with severe COVID-19	129
A neighboring NLR negatively regulates the wheat broad-spectrum resistance protein encoded by Pm21	123
Genetic mutations across multiple pathways drive filamentous growth and virulence in the emerging fungal pathogen Candida auris	113
Microbe-induced gene silencing explores interspecies RNAi and opens up possibilities of crop protection	110
Dissecting the cell microenvironment of ovarian endometrioma through single-cell RNA sequencing	108
Cytokines-activated nuclear IKKα-FAT10 pathway induces breast cancer tamoxifen-resistance	103
Movie therapy for children with amblyopia: restoring binocular vision with brain plasticity	85
New loci for refractive errors and ocular biometric parameters in young Chinese Han adults	85
Convergent and conserved roads lead to Rome: now archaea fill the gap of transcription termination	71
Inhibition of KDM6B prevents osteoarthritis by blocking growth plate-like H3K27me3 loss in bivalent genes	69
The genetic basis and process of inbreeding depression in an elite hybrid rice	65
Quantitative characterization of filamentous fungal promoters on a single-cell resolution to discover cryptic natural products	62
Vibration mechanics involved in buzz pollination lead to size-dependent associations between bumblebees and Pedicularis flowers	58
Advances in genotypic antimicrobialresistance testing: a comprehensive review	57
Danhong Injection targets CaMKII through Dihydrotanshinone I to alleviate cardiomyocyte death and inflammation in viral myocarditis	57
Pseudo-chromosome—length genome assembly for a deep-sea eel Ilyophis brunneus sheds light on the deep-sea adaptation	56
Dietary carbohydrate intake and risk of type 2 diabetes: a 16-year prospective cohort study	56
Loss of Tet hydroxymethylase activity causes mouse embryonic stem cell differentiation bias and developmental defects	53
Green manuring relocates microbiomes in driving the soil functionality of nitrogen cycling to obtain preferable grain yields in thirty years	51

Enlarged fins of Tibetan catfish provide new evidence of adaptation to high plateau	50
m6A reader YTHDF2 governs the onset of atrial fibrillation by modulating Cacna1c translation	50
Integration of perioperative features and intragraft TCF7L2 expression to predict lipid metabolic disorder in liver transplant recipients	49
Burch colposuspension for stress urinary incontinence: a 14-year prospective follow-up	49
FHL2 deficiency aggravates Candida albicans infection through decreased myelopoiesis	47
NAP-seq: unveiling the hidden world of noncapped RNAs	47
Enlarged DNA unwinding by Nme2Cas9 permits a broadened base editing window beyond the protospacer	47
Unraveling the diversity of bile acid modifications by integrative mass spectrometry approaches	46
CRISPR screening identifies protein methylation and ubiquitination modifications that modulate aflatoxin B1 cytotoxicity	45
PanSci: decoding panoramas of ageing	45
Attenuation of plant immune kinases by U-box type E3 ubiquitin ligases	44
TEDD 2.0: an advanced temporal gene expression database enabled by in-silico functional analyses for developmental mechanism investigation	43
Systems metabolic engineering of Phaffia rhodozyma for ultra-high astaxanthin production through multiple strategies	43
Mobile ARGONAUTE 1d binds 22-nt miRNAs to generate phasiRNAs important for low-temperature male fertility in rice	42
Advances and applications in single-cell and spatial genomics	42
Nitrogen addition promotes soil carbon accumulation globally	40
Genetically encoded redox biosensor system for H2O2 measurement in four subcellular compartments in acute myeloid leukemia (AML) cells	40
Predicting Lactobacillus delbrueckii subsp. bulgaricus-Streptococcus thermophilus interactions based on a highly accurate semi-supervised learning method	40
Critical roles of non-coding RNAs in lifecycle and biology of Marek’s disease herpesvirus	39
Precision regulation of plant aromatic amino acid homeostasis	39
An artificial immune switch system: engineering durable, broad-spectrum disease resistance in plants	39
Integrative analysis based on CRISPR screen identifies apilimod as a potential therapeutic agent for cisplatin-induced acute kidney injury treatment	37
Activating the cGAS-STING pathway in hypoxic microenvironment: blocking ADSL’s ER localization	36
Plant and fungal species interactions differ between aboveground and belowground habitats in mountain forests of eastern China	35
A shared role of the myocardin-family transcriptional coactivators in cardiomyocyte maturation	35
Ser68 phosphoregulation is essential for CENP-A deposition, centromere function and viability in mice	35
A neural m6A pathway regulates behavioral aggregation in migratory locusts	34
Human TRMT1 catalyzes m2G or m22G formation on tRNAs in a substrate-dependent manner	33
Effect of SARS-CoV-2 infection in early pregnancy on placental development	33
Interplant communication: an emerging battlefield in plant-aphid-virus interactions	33
Multi-omics study reveals a light-dependent regulatory network of flavonoid biosynthesis in lettuce (Lactuca sativa L.)	33
Nematode-induced trap formation regulated by the histone H3K4 methyltransferase AoSET1 in the nematode-trapping fungus Arthrobotrys oligospora	33
Ginsenoside Rb1 inhibits oxidative stress-induced ovarian granulosa cell injury through Akt-FoxO1 interaction	32
The genomic and immunogenomic landscape of mechanics pathway informs clinical prognosis and response to mechanotherapy	32
Low-affinity SPL binding sites contribute to subgenome expression divergence in allohexaploid wheat	31
Phase separation of a master transcription factor targeted by a natural compound regulates fungal ergosterol homeostasis	31
Cereal-legume intercropping stimulates straw decomposition and promotes soil organic carbon stability	31
Antibody-based targeted protein degradation for membrane and extracellular proteins: emerging strategies and breakthroughs	30
Animal burrows as critical thermal refuges in the age of climate change	30
HIV encephalopathy is contributed by macrophages and microglia	30
Analysis of non-coding small RNA similarity/sharing between plant and animal genomes	29
Peripheral blood RNA modifications as a novel diagnostic signature for polycystic ovary syndrome	29
Altered 3D genome reorganization mediates precocious myeloid differentiation of aged hematopoietic stem cells in inflammation	29
Priming crops for heat stress with prime editing	29
Redox state of NAD modulates the activation of Na-bicarbonate cotransporter NBCe1-B via IRBIT and L-IRBIT	28
Upgraded durian genome reveals the role of chromosome reshuffling during ancestral karyotype evolution, lignin biosynthesis regulation, and stress tolerance	28
From modeling to therapy: the efficient and precise tools for mitochondrial base editing	28
Enhancing sheepgrass through genomic exploration and targeted editing	28
Natural polymorphisms of COOL1 contribute to cold tolerance adaptation in maize	28
Studying bona fide SARS-CoV-2 biology in a BSL-2 biosafety environment using a split-virus-genome system	28

Longitudinal plasma proteomic evidence linking SARS-CoV-2 infection to increased β-amyloid pathology	28
Explore the nucleolus: unveiling the hidden layer with super-resolution microscopy	28
Design of a novel chimeric peptide via dual blockade of CD47/SIRPα and PD-1/PD-L1 for cancer immunotherapy	27
Versatile plant genome engineering using anti-CRISPR-Cas12a systems	27
Piceatannol enhances Beclin-1 activity to suppress tumor progression and its combination therapy strategy with everolimus in gastric cancer	27
Chemical defense mediates population density-driven on anuran brain size evolution	27
Three-dimensional visualization of tip-vesicles in growing pollen tubes by electron tomography	27
Decoding the fish genome opens a new era in important trait research and molecular breeding in China	26
Thermotolerance in rice	26
One-step base editing in multiple genes by direct embryo injection for pig trait improvement	26
Lentiviral vectors for gene therapy of α-thalassemia	25
Erratum to: A thorough analysis of diabetes research in China from 1995 to 2015: current scenario and future scope	25
Convergent selection of a gene in cereals leads to grain yield upgradation	25
Potential oligonucleotide drugs in Bencao sRNA Atlas (II)	25
A new model system for cotton indoor genetic and genomic research	24
Hot breath, quick exit: aphids flee mammalian heat via TRPA1	24
PIWI-specific insertion module: a newly identified regulatory element essential for longer piRNAs loading and male fertility	24
The OsRqc1-OsVms1 module regulates the temperature threshold in thermo-sensitive genic male-sterile rice lines	24
Erratum to: Local administration of liposomal-based Plekhf1 gene therapy attenuates pulmonary fibrosis by modulating macrophage polarization	24
Gene-knockout by iSTOP enables rapid reproductive disease modeling and phenotyping in germ cells of the founder generation	23
Tree of life and conservation of gymnosperms in China	23
A hidden translatome in tumors—the coding lncRNAs	23
PDGFR kinase inhibitor protects against septic death via regulation of BTLA	23
Distinct roles of H3K27me3 and H3K36me3 in vernalization response, maintenance, and resetting in winter wheat	23
A synthetic microbial community used as a bioinoculant can overcome rice production constraints in acid soils	23
Ancient genomes reveal the genetic inheritance and recent introgression in Chinese indigenous pigs	22
Green revolution gene drives adaptation of Arabidopsis to the extremely high altitude	22
An iron-dependent form of non-canonical ferroptosis induced by labile iron	22
RNA modifications: bridging the gap between molecular mechanisms and clinical applications	22
Gut microbiome and postbiotics: bridging the dietary nutrition and feed efficiency in food-producing animals	22
Crop antiviral defense: Past and future perspective	21
The discovery of type IV interferon system revolutionizes interferon family and opens up a new frontier in jawed vertebrate immune defense	21
LncRNA CFAR promotes cardiac fibrosis via the miR-449a-5p/LOXL3/mTOR axis	21
Targeting LTA4H facilitates the reshaping of the immune microenvironment mediated by CCL5 and sensitizes ovarian cancer to Cisplatin	21
Activating translation by phase separation: a novel mechanism for driving spermiogenesis	21
Nitrogen addition and mowing alter drought resistance and recovery of grassland communities	21
In-depth urinary and exosome proteome profiling analysis identifies novel biomarkers for diabetic kidney disease	20
PRC2 primes bivalent genes for transcription induction independent of histone methyltransferase activity	20
Galacto-oligosaccharides enrich galactosidase-encoded rather than all Lachnospiraceae bacteria to redress abnormal gut microbiota and lipid metabolism in pregnancy	20
Optimized inner ear organoids for efficient hair cell generation and ototoxicity response modeling	20
Insulin-like growth factor binding proteins 7 prevents dental pulp-derived mesenchymal stem cell senescence via metabolic downregulation of p21	20
Deamidation enables pathogenic SMAD6 variants to activate the BMP signaling pathway	20
Building the Chordata Olfactory Receptor Database using more than 400,000 receptors annotated by Genome2OR	20
Surveillance of emerging infectious diseases for biosecurity	20
Distinct and shared endothermic strategies in the heat producing tissues of tuna and other teleosts	20
Transient chemical-mediated epigenetic modulation confers unrestricted lineage potential on human primed pluripotent stem cells	19
Identification and validation of key biomarkers and potential therapeutic targets for primary open-angle glaucoma	19
Overcoming genotypic dependency and bypassing immature embryos in wheat transformation by using morphogenic regulators	19
Development and performance evaluation of a culture-independent nanopore amplicon-based sequencing method for accurate typing and antimicrobial resistance profiling in Neisseria gonorrhoeae	19
Ribo-seq provides additional evidence for cytoplasm-translated mitochondrial DNA-encoded ORFs	19
Intra-articular injection of stromal vascular fraction for knee degenerative joint disease: a concise review of preclinical and clinical evidence	19
Low-dose exposure to microplastics retards meiotic maturation via HDAC3 insufficiency	19
CARs: a new approach for the treatment of autoimmune diseases	19
Genomic analysis of modern maize inbred lines reveals diversity and selective breeding effects	19
The discovery of tiny RNAs that have crucial roles	18
Occurrence and distribution of geminiviruses in China	18
Low-dose lactate promotes neuroinflammation and induces the side effect of colitis	18
OsRLCK160 contributes to flavonoid accumulation and UV-B tolerance by regulating OsbZIP48 in rice	18
CD146, a therapeutic target involved in cell plasticity	18
Efficient generation of all ESC-derived mice carrying a homozygous lethal mutation through eight-cell embryo injection	18
Profile of Dr. Shaorong Gao	18
Genetic advancements and future directions in ruminant livestock breeding: from reference genomes to multiomics innovations	18
Zooming on T cells in cancer	18
Mapping and analysis of a spatiotemporal H3K27ac and gene expression spectrum in pigs	18
GLA deficiency causes cardiac hypertrophy via enhanced autophagy	18
Nucleolar stress promotes and cooperates with ferroptosis to suppress cancer growth	17
Rice GWAS-to-Gene uncovers the polygenic basis of traits	17
Antithetical impacts of deleterious LRP1B mutations in non-squamous and squamous NSCLCs on predicting benefits from immune checkpoint inhibitor alone or with chemotherapy over chemotherapy alone: retr	17
Cryo-EM structures reveal the dynamic transformation of human alpha-2-macroglobulin working as a protease inhibitor	17
Cell-supporting cytoskeletons and phagocytic acquisition of compatible solutes emerge as common strategies for high-salt adaptation in different ciliates	17
Diversity and connectedness of brine shrimp viruses in global hypersaline ecosystems	17
Advances in regulation and function of stearoyl-CoA desaturase 1 in cancer, from bench to bed	17
A paternal protein facilitates sperm RNA delivery to regulate zygotic development	17
Integrating spatial transcriptomics and single-nucleus RNA-seq revealed the specific inhibitory effects of TGF-β on intramuscular fat deposition	17
Atmospheric humidity regulates same-sex mating in Candida albicans through the trehalose and osmotic signaling pathways	17
Compound muscle action potential (CMAP) scan examination of paretic and contralateral muscles reveals motor unit alterations after stroke	17
Plant synthetic epigenomic engineering for crop improvement	16
Decoupled responses of soil microbial diversity and ecosystem functions to successive degeneration processes in alpine pioneer community	16
Innate and adaptive immune abnormalities underlying autoimmune diseases: the genetic connections	16
LPS-related muscle loss is associated with the alteration of Bacteroidetes abundance, systemic inflammation, and mitochondrial morphology in a weaned piglet model	16

A twist in the tale: global insights into archaeal box C/D RNA-guided 2′-O-methylation	16
Identification of EPOR and JAK2 double heterozygous variants in twin cases with familial erythrocytosis	16
When smoke meets gut: deciphering the interactions between tobacco smoking and gut microbiota in disease development	16
The spatial transcriptomic landscape of human gingiva in health and periodontitis	16
m6A modification of plant virus enables host recognition by NMD factors in plants	16
Wheat stripe rust resistance gene Yr9, derived from rye, is a CC-NBS-LRR gene in a highly conserved NLR cluster	16
G9a/GLP catalyzes H3K14me1 and H3K14me2 in vivo and in vitro	16
Enhancing whole yeast genome rearrangements through multiple LoxPsym sequences	16
Developing a robust genome editing tool based on an endogenous type I-B CRISPR-Cas system in Saccharopolyspora spinosa	16
Autophagy mediates a direct synergistic interaction during co-transmission of two distinct arboviruses by insect vectors	16
The effect of SARS-CoV-2 infection on human embryo early development: a multicenter prospective cohort study	16
Profile of Dr. Jiaojun Zhu	16
MtLICK1/2: gatekeepers of symbiosis and immunity in Medicago truncatula	15
Multifactorial and multiplexed epigenomic profiling of five DNA modifications in plants with mDIP-seq	15
Morphological and physiological responses to aridity in narrowly- and widely-distributed plant species in drylands	15
Loop CD20/CD19 CAR-T cells eradicate B-cell malignancies efficiently	15
Unraveling the origins of PGY-sRNA-6, BZL-sRNA-20, and XKC-sRNA-h3	15
SUB1 promotes colorectal cancer metastasis by activating NF-κB signaling via UBR5-mediated ubiquitination of UBXN1	15
Cracking the chitin code: how a single pair of LysM receptors deciphers symbiosis and immunity in Marchantia	15
Harnessing the Streptomyces-originating type I-E CRISPR/Cas system for efficient genome editing in Streptomyces	15
Structure of a histone hexamer bound by the chaperone domains of SPT16 and MCM2	15
TIP60 acetylation of Bub1 regulates centromeric H2AT120 phosphorylation for faithful chromosome segregation	14
Single-nucleus RNA sequencing reveals the underlying roadmap of early gonadal differentiation in teleost	14
Individual and joint exposures to PM2.5 constituents and mortality risk among the oldest-old in China	14
MYC promotes global transcription in part by controlling P-TEFb complex formation via DNA-binding independent inhibition of CDK9 SUMOylation	14
Erratum to: FSIP1 enhances the therapeutic sensitivity to CDK4/6 inhibitors in triple-negative breast cancer patients by activating the Nanog pathway	14
Mechanical transmission enables EMT cancer cells to drive epithelial cancer cell migration to guide tumor spheroid disaggregation	14
Strategic codon selection for enhanced genetic code expansion	14
Autoinhibition and cofactors of a helper NLR	14
Exploring the R-ISS stage-specific regular networks in the progression of multiple myeloma at single-cell resolution	14
Effector modularity promotes functional diversification and evolutionary processes	14
Potential oligonucleotide drugs in Bencao sRNA Atlas	14
Evolution of drug classification, target distribution, and introduction of novel antidepressants in China	14
Enhancement of in vitro transcribed (IVT) mRNA translation efficiency through engineered poly(A) tails	14
Applications and grants of the National Natural Science Foundation of China’s General Program and Young Scientists Fund in immunology research: a 10-year review (2013–2022)	14
SETD3-mediated histidine methylation of MCM7 regulates DNA replication by facilitating chromatin loading of MCM	14
Yield and quality properties of silage maize and their influencing factors in China	14
From oral structure to molecular evidence: new insights into the evolutionary phylogeny of the ciliate order Sessilida (Protista, Ciliophora), with the establishment of two new families and new contri	13
Progress and gaps in antimicrobial resistance research within One Health sectors in China: a systematic analysis	13
Chromatin accessibility landscape during mammalian preimplantation development	13
Microbial bile acid modifications: current understandings, key problems, and future perspectives	13
Sequencing and characterizing human mitochondrial genomes in the biobank-based genomic research paradigm	13
Transcriptome-wide identification of glycoRNAs by Clier-seq pipeline	13
Redox-stress response resistance (RRR) mediated by hyperoxidation of peroxiredoxin 2 in senescent cells	13
Recent advances in RNA structurome	13
Distant cousins come to ABP1’s rescue	13
Transformation of cognition from mechanical to biological aqueous outflow pump may be a breakthrough in solving the problem of intraocular pressure regulation in glaucoma	13
Computer-aided engineering of CRISPR-Cas proteins for enhanced human genome editing	13
Structural characterization of SARS-CoV-2 dimeric ORF9b reveals potential fold-switching trigger mechanism	13
Reversing anther thermotolerance by manipulating the cis-elements in the promoter of a high-temperature upregulated gene Casein Kinase I in upland cotton	13
Global multifaceted biodiversity patterns, centers, and conservation needs in angiosperms	13
Treating incurable non-communicable diseases by targeting iron metabolism and ferroptosis	13
Functional microglia derived from human pluripotent stem cells empower retinal organs	13
Prioritization of risk genes in colorectal cancer by integrative analysis of multi-omics data and gene networks	13
Biosynthesis of melanin from lignin hydrolysates by metabolically engineered Cupriavidus necator	13
Deubiquitinases in liver diseases: from mechanisms to targeted therapy	13
Local field potentials, spiking activity, and receptive fields in human visual cortex	13
Cucumber green mottle mosaic virus encodes additional small proteins with specific subcellular localizations and virulence function	13
Whole grain black rice: a paradigm shift from mainly calories to a nutritious food that benefits human health	12
A new era of mass data storage in artificial chromosome	12
Extracellular vesicles in cancer progression: mechanisms and significance	12
The role of corneal endothelium in macular corneal dystrophy development and recurrence	12
Bactericidal bissulfone B7 targets bacterial pyruvate kinase to impair bacterial biology and pathogenicity in plants	12
Birth-and-death evolution of ribonuclease 9 genes in Cetartiodactyla	12
Imaging-guided non-invasive in vivo acoustic printing: a new “surgery-as-printing” paradigm for precision medicine	12
Dietary iron regulates intestinal goblet cell function and alleviates Salmonella typhimurium invasion in mice	12
Functional cancer-cell-nociceptive neuronal circuits drive gastric tumor progression	12
The repression of oncoprotein SET by the tumor suppressor p53 reveals a p53-SET-PP2A feedback loop for cancer therapy	12
A comprehensive review on natural phenolic compounds as alternatives to in-feed antibiotics	12
Genome-wide signatures of the geographic expansion and breeding of soybean	12
Functional characterization of novel NPRL3 mutations identified in three families with focal epilepsy	12
Amino acids TORC (talk) to anabolism through uncharged tRNA	12
GMNN mutations cause female infertility characterized by preimplantation embryo arrest through regulating DNA re-replication	12
A strategy for the development of receptor-containing antibodies targeting malaria variant surface antigens	12
Truncated glycoprotein E of varicella-zoster virus is an ideal immunogen for Escherichia coli-based vaccine design	12
Development of regenerative therapies targeting fibrotic endometrium in intrauterine adhesion or thin endometrium to restore uterine function	12
Crosstalk between brassinosteroid signaling and variable nutrient environments	12
Dynamic landscape and regulation of m5C methylation in human tissues	11
Dual phosphorylation of DISC1 at Ser58 and Ser713 regulates polarization of cortical neurons via GSK3β	11
Molecular mechanisms of DNA lesion and repair during antibody somatic hypermutation	11
Single-base resolution mapping of 2′-O-methylation sites by an exoribonuclease-enriched chemical method	11
Convergent patterns in multitrophic biodiversity effects on yield across ecosystems	11
Benyuan Charity Fund-Young Investigator Exploration Award	11
Automatic quantification, grading and five-year prediction of myopic fundus tessellation: a multi-center, longitudinal deep learning study	11
Therapeutic hypothermia for acute ischemic stroke: from preclinical studies to clinical trials	11
Combined effects of climate and land-use changes on the alpha and beta functional diversities of terrestrial mammals in China	11
Engineered CLE peptides promote de novo shoot regeneration in Arabidopsis	11
Generation of transient totipotent blastomere-like stem cells by short-term high-dose Pladienolide B treatment	11
Single-nucleus transcriptome profiling of wild boar and domestic pig intestines reveals the spatiotemporal dynamics of immunity and nutrient absorption	11
Unraveling phylogenetic conflicts and adaptive evolution in Chiroptera using large-scale mitogenomes and nuclear genes	11
WNT2/2B double homologous knockout blocks lung development and formation in pigs	11
Stroma-specific IL-15 coordinates epithelial IL-15Rα to promote intestinal epithelial repair	11
Assessing the ecological effects of the World’s Largest Forestry Eco-engineering: Three-North Protective Forest Program within the initially scheduled range from 1978 to 2022	11
SNX25-mediated regulation of NGF by Periploca sepium periplosides from Xiangjiapi in macrophage-dependent anti-nociception	11
DDX21 is a new player in co-transcriptional RNA modification and functions	11