Science China-Life Sciences

Article	Citations
RNA ac4C modification in cancer biology: from regulatory mechanisms to clinical applications	313
What the genome of the leafy seadragon teaches us about rapid evolution of camouflage and adaptations to life in the kelp forest	284
Metatranscriptomic analysis of host response and vaginal microbiome of patients with severe COVID-19	259
New insights from a plant immune receptor may help design of disease resistant crops	182
Enlarged fins of Tibetan catfish provide new evidence of adaptation to high plateau	148
Unveiling potential sex-determining genes and sex-specific markers in autotetraploid Carassius auratus	125
Nanowire-mediated miRNA delivery	123
Genetic mutations across multiple pathways drive filamentous growth and virulence in the emerging fungal pathogen Candida auris	115
Loss of Tet hydroxymethylase activity causes mouse embryonic stem cell differentiation bias and developmental defects	114
Vibration mechanics involved in buzz pollination lead to size-dependent associations between bumblebees and Pedicularis flowers	111
Danhong Injection targets CaMKII through Dihydrotanshinone I to alleviate cardiomyocyte death and inflammation in viral myocarditis	97
Quantitative characterization of filamentous fungal promoters on a single-cell resolution to discover cryptic natural products	95
Green manuring relocates microbiomes in driving the soil functionality of nitrogen cycling to obtain preferable grain yields in thirty years	95
Microbe-induced gene silencing explores interspecies RNAi and opens up possibilities of crop protection	90
Advances in genotypic antimicrobialresistance testing: a comprehensive review	80
m6A reader YTHDF2 governs the onset of atrial fibrillation by modulating Cacna1c translation	72
Movie therapy for children with amblyopia: restoring binocular vision with brain plasticity	68
Pseudo-chromosome—length genome assembly for a deep-sea eel Ilyophis brunneus sheds light on the deep-sea adaptation	67
The genetic basis and process of inbreeding depression in an elite hybrid rice	65
Dietary carbohydrate intake and risk of type 2 diabetes: a 16-year prospective cohort study	58
New loci for refractive errors and ocular biometric parameters in young Chinese Han adults	58
Cytokines-activated nuclear IKKα-FAT10 pathway induces breast cancer tamoxifen-resistance	55
Dissecting the cell microenvironment of ovarian endometrioma through single-cell RNA sequencing	53
Convergent and conserved roads lead to Rome: now archaea fill the gap of transcription termination	53
Inhibition of KDM6B prevents osteoarthritis by blocking growth plate-like H3K27me3 loss in bivalent genes	52

Burch colposuspension for stress urinary incontinence: a 14-year prospective follow-up	49
Integration of perioperative features and intragraft TCF7L2 expression to predict lipid metabolic disorder in liver transplant recipients	48
Enlarged DNA unwinding by Nme2Cas9 permits a broadened base editing window beyond the protospacer	47
FHL2 deficiency aggravates Candida albicans infection through decreased myelopoiesis	47
An artificial immune switch system: engineering durable, broad-spectrum disease resistance in plants	46
The genomic and immunogenomic landscape of mechanics pathway informs clinical prognosis and response to mechanotherapy	44
Mobile ARGONAUTE 1d binds 22-nt miRNAs to generate phasiRNAs important for low-temperature male fertility in rice	44
Ser68 phosphoregulation is essential for CENP-A deposition, centromere function and viability in mice	44
Predicting Lactobacillus delbrueckii subsp. bulgaricus-Streptococcus thermophilus interactions based on a highly accurate semi-supervised learning method	42
Multi-omics study reveals a light-dependent regulatory network of flavonoid biosynthesis in lettuce (Lactuca sativa L.)	41
NAP-seq: unveiling the hidden world of noncapped RNAs	41
Unraveling the diversity of bile acid modifications by integrative mass spectrometry approaches	40
A shared role of the myocardin-family transcriptional coactivators in cardiomyocyte maturation	40
CRISPR screening identifies protein methylation and ubiquitination modifications that modulate aflatoxin B1 cytotoxicity	39
PanSci: decoding panoramas of ageing	38
Systems metabolic engineering of Phaffia rhodozyma for ultra-high astaxanthin production through multiple strategies	38
Attenuation of plant immune kinases by U-box type E3 ubiquitin ligases	38
A neural m6A pathway regulates behavioral aggregation in migratory locusts	37
Interplant communication: an emerging battlefield in plant-aphid-virus interactions	37
Low-affinity SPL binding sites contribute to subgenome expression divergence in allohexaploid wheat	36
Integrative analysis based on CRISPR screen identifies apilimod as a potential therapeutic agent for cisplatin-induced acute kidney injury treatment	35
Dogs lacking Apolipoprotein E show advanced atherosclerosis leading to apparent clinical complications	35
Human TRMT1 catalyzes m2G or m22G formation on tRNAs in a substrate-dependent manner	34
Precision regulation of plant aromatic amino acid homeostasis	34
Cereal-legume intercropping stimulates straw decomposition and promotes soil organic carbon stability	33
Critical roles of non-coding RNAs in lifecycle and biology of Marek’s disease herpesvirus	33
Advances and applications in single-cell and spatial genomics	33
Plant and fungal species interactions differ between aboveground and belowground habitats in mountain forests of eastern China	33
Genetically encoded redox biosensor system for H2O2 measurement in four subcellular compartments in acute myeloid leukemia (AML) cells	32
Activating the cGAS-STING pathway in hypoxic microenvironment: blocking ADSL’s ER localization	32
Phase separation of a master transcription factor targeted by a natural compound regulates fungal ergosterol homeostasis	30
Nematode-induced trap formation regulated by the histone H3K4 methyltransferase AoSET1 in the nematode-trapping fungus Arthrobotrys oligospora	30
Effect of SARS-CoV-2 infection in early pregnancy on placental development	30
Upgraded durian genome reveals the role of chromosome reshuffling during ancestral karyotype evolution, lignin biosynthesis regulation, and stress tolerance	29
Enhancing sheepgrass through genomic exploration and targeted editing	29
Nitrogen addition promotes soil carbon accumulation globally	29
Peripheral blood RNA modifications as a novel diagnostic signature for polycystic ovary syndrome	29
Ginsenoside Rb1 inhibits oxidative stress-induced ovarian granulosa cell injury through Akt-FoxO1 interaction	29
HIV encephalopathy is contributed by macrophages and microglia	28
Versatile plant genome engineering using anti-CRISPR-Cas12a systems	28
Longitudinal plasma proteomic evidence linking SARS-CoV-2 infection to increased β-amyloid pathology	28
Animal burrows as critical thermal refuges in the age of climate change	28
Altered 3D genome reorganization mediates precocious myeloid differentiation of aged hematopoietic stem cells in inflammation	27
Chemical defense mediates population density-driven on anuran brain size evolution	27
Analysis of non-coding small RNA similarity/sharing between plant and animal genomes	27
Studying bona fide SARS-CoV-2 biology in a BSL-2 biosafety environment using a split-virus-genome system	27
Natural polymorphisms of COOL1 contribute to cold tolerance adaptation in maize	27
Explore the nucleolus: unveiling the hidden layer with super-resolution microscopy	27
Decoding the fish genome opens a new era in important trait research and molecular breeding in China	26
One-step base editing in multiple genes by direct embryo injection for pig trait improvement	26

Priming crops for heat stress with prime editing	26
Redox state of NAD modulates the activation of Na-bicarbonate cotransporter NBCe1-B via IRBIT and L-IRBIT	26
Design of a novel chimeric peptide via dual blockade of CD47/SIRPα and PD-1/PD-L1 for cancer immunotherapy	26
Antibody-based targeted protein degradation for membrane and extracellular proteins: emerging strategies and breakthroughs	26
Piceatannol enhances Beclin-1 activity to suppress tumor progression and its combination therapy strategy with everolimus in gastric cancer	26
Thermotolerance in rice	25
From modeling to therapy: the efficient and precise tools for mitochondrial base editing	25
RNA modifications: bridging the gap between molecular mechanisms and clinical applications	25
Lentiviral vectors for gene therapy of α-thalassemia	24
The OsRqc1-OsVms1 module regulates the temperature threshold in thermo-sensitive genic male-sterile rice lines	24
Convergent selection of a gene in cereals leads to grain yield upgradation	24
A synthetic microbial community used as a bioinoculant can overcome rice production constraints in acid soils	24
A hidden translatome in tumors—the coding lncRNAs	24
In-depth urinary and exosome proteome profiling analysis identifies novel biomarkers for diabetic kidney disease	24
PIWI-specific insertion module: a newly identified regulatory element essential for longer piRNAs loading and male fertility	23
Green revolution gene drives adaptation of Arabidopsis to the extremely high altitude	23
A new model system for cotton indoor genetic and genomic research	23
Hot breath, quick exit: aphids flee mammalian heat via TRPA1	23
Potential oligonucleotide drugs in Bencao sRNA Atlas (II)	23
An iron-dependent form of non-canonical ferroptosis induced by labile iron	23
Coronavirus transmissible gastroenteritis virus antagonizes the antiviral effect of the microRNA miR-27b via the IRE1 pathway	22
Erratum to: A thorough analysis of diabetes research in China from 1995 to 2015: current scenario and future scope	22
Gene-knockout by iSTOP enables rapid reproductive disease modeling and phenotyping in germ cells of the founder generation	22
Ancient genomes reveal the genetic inheritance and recent introgression in Chinese indigenous pigs	21
Optimized inner ear organoids for efficient hair cell generation and ototoxicity response modeling	21
Nitrogen addition and mowing alter drought resistance and recovery of grassland communities	21
Erratum to: Local administration of liposomal-based Plekhf1 gene therapy attenuates pulmonary fibrosis by modulating macrophage polarization	21
Gut microbiome and postbiotics: bridging the dietary nutrition and feed efficiency in food-producing animals	21
PDGFR kinase inhibitor protects against septic death via regulation of BTLA	20
Targeting LTA4H facilitates the reshaping of the immune microenvironment mediated by CCL5 and sensitizes ovarian cancer to Cisplatin	20
Distinct roles of H3K27me3 and H3K36me3 in vernalization response, maintenance, and resetting in winter wheat	20
Activating translation by phase separation: a novel mechanism for driving spermiogenesis	20
Building the Chordata Olfactory Receptor Database using more than 400,000 receptors annotated by Genome2OR	20
Surveillance of emerging infectious diseases for biosecurity	20
Crop antiviral defense: Past and future perspective	20
The discovery of type IV interferon system revolutionizes interferon family and opens up a new frontier in jawed vertebrate immune defense	19
CD146, a therapeutic target involved in cell plasticity	19
Occurrence and distribution of geminiviruses in China	19
Deamidation enables pathogenic SMAD6 variants to activate the BMP signaling pathway	19
Insulin-like growth factor binding proteins 7 prevents dental pulp-derived mesenchymal stem cell senescence via metabolic downregulation of p21	19
Development and performance evaluation of a culture-independent nanopore amplicon-based sequencing method for accurate typing and antimicrobial resistance profiling in Neisseria gonorrhoeae	19
Genetic advancements and future directions in ruminant livestock breeding: from reference genomes to multiomics innovations	19
LncRNA CFAR promotes cardiac fibrosis via the miR-449a-5p/LOXL3/mTOR axis	19
PRC2 primes bivalent genes for transcription induction independent of histone methyltransferase activity	19
Intra-articular injection of stromal vascular fraction for knee degenerative joint disease: a concise review of preclinical and clinical evidence	19
Transient chemical-mediated epigenetic modulation confers unrestricted lineage potential on human primed pluripotent stem cells	18
CARs: a new approach for the treatment of autoimmune diseases	18
Overcoming genotypic dependency and bypassing immature embryos in wheat transformation by using morphogenic regulators	18
Low-dose exposure to microplastics retards meiotic maturation via HDAC3 insufficiency	18
Galacto-oligosaccharides enrich galactosidase-encoded rather than all Lachnospiraceae bacteria to redress abnormal gut microbiota and lipid metabolism in pregnancy	18
Zooming on T cells in cancer	18
OsRLCK160 contributes to flavonoid accumulation and UV-B tolerance by regulating OsbZIP48 in rice	18
Ribo-seq provides additional evidence for cytoplasm-translated mitochondrial DNA-encoded ORFs	18
Identification and validation of key biomarkers and potential therapeutic targets for primary open-angle glaucoma	18
The discovery of tiny RNAs that have crucial roles	18
Diversity and connectedness of brine shrimp viruses in global hypersaline ecosystems	18
Distinct and shared endothermic strategies in the heat producing tissues of tuna and other teleosts	18
Genomic analysis of modern maize inbred lines reveals diversity and selective breeding effects	18
Rice GWAS-to-Gene uncovers the polygenic basis of traits	17
Efficient generation of all ESC-derived mice carrying a homozygous lethal mutation through eight-cell embryo injection	17
The TFIID pivot of preinitiation complex	17
A paternal protein facilitates sperm RNA delivery to regulate zygotic development	17
Profile of Dr. Shaorong Gao	17
Developing a robust genome editing tool based on an endogenous type I-B CRISPR-Cas system in Saccharopolyspora spinosa	17
Innate and adaptive immune abnormalities underlying autoimmune diseases: the genetic connections	17
When smoke meets gut: deciphering the interactions between tobacco smoking and gut microbiota in disease development	17
Nucleolar stress promotes and cooperates with ferroptosis to suppress cancer growth	17
Antithetical impacts of deleterious LRP1B mutations in non-squamous and squamous NSCLCs on predicting benefits from immune checkpoint inhibitor alone or with chemotherapy over chemotherapy alone: retr	17
GLA deficiency causes cardiac hypertrophy via enhanced autophagy	16
Low-dose lactate promotes neuroinflammation and induces the side effect of colitis	16
Decoupled responses of soil microbial diversity and ecosystem functions to successive degeneration processes in alpine pioneer community	16
The effect of SARS-CoV-2 infection on human embryo early development: a multicenter prospective cohort study	16
Advances in regulation and function of stearoyl-CoA desaturase 1 in cancer, from bench to bed	16
Mapping and analysis of a spatiotemporal H3K27ac and gene expression spectrum in pigs	16
Wheat stripe rust resistance gene Yr9, derived from rye, is a CC-NBS-LRR gene in a highly conserved NLR cluster	16
LPS-related muscle loss is associated with the alteration of Bacteroidetes abundance, systemic inflammation, and mitochondrial morphology in a weaned piglet model	16
Autophagy mediates a direct synergistic interaction during co-transmission of two distinct arboviruses by insect vectors	16
Compound muscle action potential (CMAP) scan examination of paretic and contralateral muscles reveals motor unit alterations after stroke	16
Cryo-EM structures reveal the dynamic transformation of human alpha-2-macroglobulin working as a protease inhibitor	16
Cell-supporting cytoskeletons and phagocytic acquisition of compatible solutes emerge as common strategies for high-salt adaptation in different ciliates	16

Techniques for increasing the yield of stem cell-derived exosomes: what factors may be involved?	16
Integrating spatial transcriptomics and single-nucleus RNA-seq revealed the specific inhibitory effects of TGF-β on intramuscular fat deposition	16
MtLICK1/2: gatekeepers of symbiosis and immunity in Medicago truncatula	15
The spatial transcriptomic landscape of human gingiva in health and periodontitis	15
G9a/GLP catalyzes H3K14me1 and H3K14me2 in vivo and in vitro	15
Cracking the chitin code: how a single pair of LysM receptors deciphers symbiosis and immunity in Marchantia	15
Individual and joint exposures to PM2.5 constituents and mortality risk among the oldest-old in China	15
Profile of Dr. Jiaojun Zhu	15
Atmospheric humidity regulates same-sex mating in Candida albicans through the trehalose and osmotic signaling pathways	15
Loop CD20/CD19 CAR-T cells eradicate B-cell malignancies efficiently	15
Identification of EPOR and JAK2 double heterozygous variants in twin cases with familial erythrocytosis	15
Unraveling the origins of PGY-sRNA-6, BZL-sRNA-20, and XKC-sRNA-h3	15
m6A modification of plant virus enables host recognition by NMD factors in plants	15
A twist in the tale: global insights into archaeal box C/D RNA-guided 2′-O-methylation	15
Plant synthetic epigenomic engineering for crop improvement	15
Enhancing whole yeast genome rearrangements through multiple LoxPsym sequences	15
Potential oligonucleotide drugs in Bencao sRNA Atlas	14
TIP60 acetylation of Bub1 regulates centromeric H2AT120 phosphorylation for faithful chromosome segregation	14
Harnessing the Streptomyces-originating type I-E CRISPR/Cas system for efficient genome editing in Streptomyces	14
Mechanical transmission enables EMT cancer cells to drive epithelial cancer cell migration to guide tumor spheroid disaggregation	14
Morphological and physiological responses to aridity in narrowly- and widely-distributed plant species in drylands	14
Multifactorial and multiplexed epigenomic profiling of five DNA modifications in plants with mDIP-seq	14
Enhancement of in vitro transcribed (IVT) mRNA translation efficiency through engineered poly(A) tails	14
Strategic codon selection for enhanced genetic code expansion	14
Applications and grants of the National Natural Science Foundation of China’s General Program and Young Scientists Fund in immunology research: a 10-year review (2013–2022)	14
Structure of a histone hexamer bound by the chaperone domains of SPT16 and MCM2	14
Yield and quality properties of silage maize and their influencing factors in China	14
SUB1 promotes colorectal cancer metastasis by activating NF-κB signaling via UBR5-mediated ubiquitination of UBXN1	14
MYC promotes global transcription in part by controlling P-TEFb complex formation via DNA-binding independent inhibition of CDK9 SUMOylation	13
Sequencing and characterizing human mitochondrial genomes in the biobank-based genomic research paradigm	13
Distant cousins come to ABP1’s rescue	13
Progress and gaps in antimicrobial resistance research within One Health sectors in China: a systematic analysis	13
Autoinhibition and cofactors of a helper NLR	13
Exploring the R-ISS stage-specific regular networks in the progression of multiple myeloma at single-cell resolution	13
Cucumber green mottle mosaic virus encodes additional small proteins with specific subcellular localizations and virulence function	13
Effector modularity promotes functional diversification and evolutionary processes	13
Local field potentials, spiking activity, and receptive fields in human visual cortex	13
Computer-aided engineering of CRISPR-Cas proteins for enhanced human genome editing	13
Treating incurable non-communicable diseases by targeting iron metabolism and ferroptosis	13
Prioritization of risk genes in colorectal cancer by integrative analysis of multi-omics data and gene networks	13
Structural characterization of SARS-CoV-2 dimeric ORF9b reveals potential fold-switching trigger mechanism	12
Biosynthesis of melanin from lignin hydrolysates by metabolically engineered Cupriavidus necator	12
From oral structure to molecular evidence: new insights into the evolutionary phylogeny of the ciliate order Sessilida (Protista, Ciliophora), with the establishment of two new families and new contri	12
Recent advances in RNA structurome	12
A novel β2-AR agonist, Higenamine, induces β-arrestin-biased signaling	12
Redox-stress response resistance (RRR) mediated by hyperoxidation of peroxiredoxin 2 in senescent cells	12
Functional characterization of novel NPRL3 mutations identified in three families with focal epilepsy	12
Whole grain black rice: a paradigm shift from mainly calories to a nutritious food that benefits human health	12
Dietary iron regulates intestinal goblet cell function and alleviates Salmonella typhimurium invasion in mice	12
SETD3-mediated histidine methylation of MCM7 regulates DNA replication by facilitating chromatin loading of MCM	12
Crosstalk between brassinosteroid signaling and variable nutrient environments	12
Reversing anther thermotolerance by manipulating the cis-elements in the promoter of a high-temperature upregulated gene Casein Kinase I in upland cotton	12
Functional microglia derived from human pluripotent stem cells empower retinal organs	12
Global multifaceted biodiversity patterns, centers, and conservation needs in angiosperms	12
Transformation of cognition from mechanical to biological aqueous outflow pump may be a breakthrough in solving the problem of intraocular pressure regulation in glaucoma	12
Erratum to: FSIP1 enhances the therapeutic sensitivity to CDK4/6 inhibitors in triple-negative breast cancer patients by activating the Nanog pathway	11
A new era of mass data storage in artificial chromosome	11
Combined effects of climate and land-use changes on the alpha and beta functional diversities of terrestrial mammals in China	11
Unraveling phylogenetic conflicts and adaptive evolution in Chiroptera using large-scale mitogenomes and nuclear genes	11
DDX21 is a new player in co-transcriptional RNA modification and functions	11
Dynamic landscape and regulation of m5C methylation in human tissues	11
The repression of oncoprotein SET by the tumor suppressor p53 reveals a p53-SET-PP2A feedback loop for cancer therapy	11
Promotion of Arabidopsis immune responses by a rhizosphere fungus via supply of pipecolic acid to plants and selective augment of phytoalexins	11
GMNN mutations cause female infertility characterized by preimplantation embryo arrest through regulating DNA re-replication	11
Automatic quantification, grading and five-year prediction of myopic fundus tessellation: a multi-center, longitudinal deep learning study	11
Extracellular vesicles in cancer progression: mechanisms and significance	11
Truncated glycoprotein E of varicella-zoster virus is an ideal immunogen for Escherichia coli-based vaccine design	11
Functional cancer-cell-nociceptive neuronal circuits drive gastric tumor progression	11
Amino acids TORC (talk) to anabolism through uncharged tRNA	11
Base editor-mediated large-scale screening of functional mutations in bacteria for industrial phenotypes	11
A strategy for the development of receptor-containing antibodies targeting malaria variant surface antigens	11
Imaging-guided non-invasive in vivo acoustic printing: a new “surgery-as-printing” paradigm for precision medicine	11
The patterns and participants of parental histone recycling during DNA replication in Saccharomyces cerevisiae	11
Single-base resolution mapping of 2′-O-methylation sites by an exoribonuclease-enriched chemical method	10
Generation of transient totipotent blastomere-like stem cells by short-term high-dose Pladienolide B treatment	10
Molecular mechanisms of DNA lesion and repair during antibody somatic hypermutation	10
Benyuan Charity Fund-Young Investigator Exploration Award	10
SNX25-mediated regulation of NGF by Periploca sepium periplosides from Xiangjiapi in macrophage-dependent anti-nociception	10
Erratum to: Developmental recording of the ghost-moth larvae after ex situ infection by Ophiocordyceps sinensis	10
Differences in intestinal microbiome are associated with the mortality of COVID-19 patients in intensive care units	10
Establishing age-group specific reference intervals of human salivary proteome and its preliminary application for epilepsy diagnosis	10
Therapeutic hypothermia for acute ischemic stroke: from preclinical studies to clinical trials	10
Bactericidal bissulfone B7 targets bacterial pyruvate kinase to impair bacterial biology and pathogenicity in plants	10
Birth-and-death evolution of ribonuclease 9 genes in Cetartiodactyla	10
Assessing the ecological effects of the World’s Largest Forestry Eco-engineering: Three-North Protective Forest Program within the initially scheduled range from 1978 to 2022	10
Ihog proteins contribute to integrin-mediated focal adhesions	10
GlycoRNA: a new frontier in RNA biology	10
Convergent patterns in multitrophic biodiversity effects on yield across ecosystems	10
Recent advances in tissue stem cells	10
Single-nucleus transcriptome profiling of wild boar and domestic pig intestines reveals the spatiotemporal dynamics of immunity and nutrient absorption	10
An improved hybrid bream derived from a hybrid lineage of Megalobrama amblycephala (♀)×Culter alburnus (♂)	10
A comprehensive review on natural phenolic compounds as alternatives to in-feed antibiotics	10
Cross-species binding spectrum of ACE2 to SARS-CoV-2 RBD	10
Targeting ARID1A: the key to dominating the differentiation fate of germinal center B cells	10
Genome-wide signatures of the geographic expansion and breeding of soybean	10