Science China-Life Sciences

Article	Citations
Metatranscriptomic analysis of host response and vaginal microbiome of patients with severe COVID-19	276
Vibration mechanics involved in buzz pollination lead to size-dependent associations between bumblebees and Pedicularis flowers	231
New insights from a plant immune receptor may help design of disease resistant crops	204
The genetic basis and process of inbreeding depression in an elite hybrid rice	165
RNA ac4C modification in cancer biology: from regulatory mechanisms to clinical applications	142
What the genome of the leafy seadragon teaches us about rapid evolution of camouflage and adaptations to life in the kelp forest	131
m6A reader YTHDF2 governs the onset of atrial fibrillation by modulating Cacna1c translation	107
Enlarged fins of Tibetan catfish provide new evidence of adaptation to high plateau	101
Unveiling potential sex-determining genes and sex-specific markers in autotetraploid Carassius auratus	98
Nanowire-mediated miRNA delivery	97
Cytokines-activated nuclear IKKα-FAT10 pathway induces breast cancer tamoxifen-resistance	96
Dietary carbohydrate intake and risk of type 2 diabetes: a 16-year prospective cohort study	95
Advances in genotypic antimicrobialresistance testing: a comprehensive review	87
Movie therapy for children with amblyopia: restoring binocular vision with brain plasticity	83
Genetic mutations across multiple pathways drive filamentous growth and virulence in the emerging fungal pathogen Candida auris	77
Microbe-induced gene silencing explores interspecies RNAi and opens up possibilities of crop protection	69
Quantitative characterization of filamentous fungal promoters on a single-cell resolution to discover cryptic natural products	66
Pseudo-chromosome—length genome assembly for a deep-sea eel Ilyophis brunneus sheds light on the deep-sea adaptation	65
MS1 is essential for male fertility by regulating the microsporocyte cell plate expansion in soybean	63
New loci for refractive errors and ocular biometric parameters in young Chinese Han adults	61
Dissecting the cell microenvironment of ovarian endometrioma through single-cell RNA sequencing	57
Inhibition of KDM6B prevents osteoarthritis by blocking growth plate-like H3K27me3 loss in bivalent genes	50
Convergent and conserved roads lead to Rome: now archaea fill the gap of transcription termination	49
Loss of Tet hydroxymethylase activity causes mouse embryonic stem cell differentiation bias and developmental defects	48
Integration of perioperative features and intragraft TCF7L2 expression to predict lipid metabolic disorder in liver transplant recipients	47

Green manuring relocates microbiomes in driving the soil functionality of nitrogen cycling to obtain preferable grain yields in thirty years	47
Genetically encoded redox biosensor system for H2O2 measurement in four subcellular compartments in acute myeloid leukemia (AML) cells	45
Interplant communication: an emerging battlefield in plant-aphid-virus interactions	44
Burch colposuspension for stress urinary incontinence: a 14-year prospective follow-up	43
CRISPR screening identifies protein methylation and ubiquitination modifications that modulate aflatoxin B1 cytotoxicity	43
A shared role of the myocardin-family transcriptional coactivators in cardiomyocyte maturation	43
Dogs lacking Apolipoprotein E show advanced atherosclerosis leading to apparent clinical complications	42
Critical roles of non-coding RNAs in lifecycle and biology of Marek’s disease herpesvirus	42
Attenuation of plant immune kinases by U-box type E3 ubiquitin ligases	41
Precision regulation of plant aromatic amino acid homeostasis	40
PanSci: decoding panoramas of ageing	39
Nematode-induced trap formation regulated by the histone H3K4 methyltransferase AoSET1 in the nematode-trapping fungus Arthrobotrys oligospora	38
A neural m6A pathway regulates behavioral aggregation in migratory locusts	38
Enlarged DNA unwinding by Nme2Cas9 permits a broadened base editing window beyond the protospacer	37
FHL2 deficiency aggravates Candida albicans infection through decreased myelopoiesis	37
NAP-seq: unveiling the hidden world of noncapped RNAs	36
Effect of SARS-CoV-2 infection in early pregnancy on placental development	36
Ser68 phosphoregulation is essential for CENP-A deposition, centromere function and viability in mice	36
The genomic and immunogenomic landscape of mechanics pathway informs clinical prognosis and response to mechanotherapy	36
Plant and fungal species interactions differ between aboveground and belowground habitats in mountain forests of eastern China	35
Cereal-legume intercropping stimulates straw decomposition and promotes soil organic carbon stability	34
Predicting Lactobacillus delbrueckii subsp. bulgaricus-Streptococcus thermophilus interactions based on a highly accurate semi-supervised learning method	34
Advances and applications in single-cell and spatial genomics	34
Human TRMT1 catalyzes m2G or m22G formation on tRNAs in a substrate-dependent manner	34
Nitrogen addition promotes soil carbon accumulation globally	34
Ginsenoside Rb1 inhibits oxidative stress-induced ovarian granulosa cell injury through Akt-FoxO1 interaction	33
Integrative analysis based on CRISPR screen identifies apilimod as a potential therapeutic agent for cisplatin-induced acute kidney injury treatment	33
Mobile ARGONAUTE 1d binds 22-nt miRNAs to generate phasiRNAs important for low-temperature male fertility in rice	32
Unraveling the diversity of bile acid modifications by integrative mass spectrometry approaches	31
Low-affinity SPL binding sites contribute to subgenome expression divergence in allohexaploid wheat	31
Decoding the fish genome opens a new era in important trait research and molecular breeding in China	30
Ferritin nanocages for early theranostics of tumors via inflammation-enhanced active targeting	30
Upgraded durian genome reveals the role of chromosome reshuffling during ancestral karyotype evolution, lignin biosynthesis regulation, and stress tolerance	29
HIV encephalopathy is contributed by macrophages and microglia	29
Enhancing sheepgrass through genomic exploration and targeted editing	29
Animal burrows as critical thermal refuges in the age of climate change	29
Studying bona fide SARS-CoV-2 biology in a BSL-2 biosafety environment using a split-virus-genome system	28
Chemical defense mediates population density-driven on anuran brain size evolution	28
Explore the nucleolus: unveiling the hidden layer with super-resolution microscopy	28
Natural polymorphisms of COOL1 contribute to cold tolerance adaptation in maize	27
Piceatannol enhances Beclin-1 activity to suppress tumor progression and its combination therapy strategy with everolimus in gastric cancer	27
Redox state of NAD modulates the activation of Na-bicarbonate cotransporter NBCe1-B via IRBIT and L-IRBIT	27
Design of a novel chimeric peptide via dual blockade of CD47/SIRPα and PD-1/PD-L1 for cancer immunotherapy	27
Analysis of non-coding small RNA similarity/sharing between plant and animal genomes	26
Priming crops for heat stress with prime editing	26
Versatile plant genome engineering using anti-CRISPR-Cas12a systems	26
Altered 3D genome reorganization mediates precocious myeloid differentiation of aged hematopoietic stem cells in inflammation	26
Activating translation by phase separation: a novel mechanism for driving spermiogenesis	25
One-step base editing in multiple genes by direct embryo injection for pig trait improvement	25
Erratum to: A thorough analysis of diabetes research in China from 1995 to 2015: current scenario and future scope	25

Thermotolerance in rice	25
Coronavirus transmissible gastroenteritis virus antagonizes the antiviral effect of the microRNA miR-27b via the IRE1 pathway	24
Convergent selection of a gene in cereals leads to grain yield upgradation	24
A synthetic microbial community used as a bioinoculant can overcome rice production constraints in acid soils	24
PIWI-specific insertion module: a newly identified regulatory element essential for longer piRNAs loading and male fertility	24
Lentiviral vectors for gene therapy of α-thalassemia	24
More abundant and healthier meat: will the MSTN editing epitome empower the commercialization of gene editing in livestock?	24
Targeting LTA4H facilitates the reshaping of the immune microenvironment mediated by CCL5 and sensitizes ovarian cancer to Cisplatin	23
Ancient genomes reveal the genetic inheritance and recent introgression in Chinese indigenous pigs	23
Building the Chordata Olfactory Receptor Database using more than 400,000 receptors annotated by Genome2OR	23
In-depth urinary and exosome proteome profiling analysis identifies novel biomarkers for diabetic kidney disease	23
LncRNA CFAR promotes cardiac fibrosis via the miR-449a-5p/LOXL3/mTOR axis	23
PDGFR kinase inhibitor protects against septic death via regulation of BTLA	23
Nitrogen addition and mowing alter drought resistance and recovery of grassland communities	22
Crop antiviral defense: Past and future perspective	22
Optimized inner ear organoids for efficient hair cell generation and ototoxicity response modeling	22
Insulin-like growth factor binding proteins 7 prevents dental pulp-derived mesenchymal stem cell senescence via metabolic downregulation of p21	22
A hidden translatome in tumors—the coding lncRNAs	22
A new model system for cotton indoor genetic and genomic research	22
Potential oligonucleotide drugs in Bencao sRNA Atlas (II)	21
Green revolution gene drives adaptation of Arabidopsis to the extremely high altitude	21
Surveillance of emerging infectious diseases for biosecurity	21
Gene-knockout by iSTOP enables rapid reproductive disease modeling and phenotyping in germ cells of the founder generation	21
The discovery of type IV interferon system revolutionizes interferon family and opens up a new frontier in jawed vertebrate immune defense	21
An iron-dependent form of non-canonical ferroptosis induced by labile iron	21
Distinct roles of H3K27me3 and H3K36me3 in vernalization response, maintenance, and resetting in winter wheat	21
Development and performance evaluation of a culture-independent nanopore amplicon-based sequencing method for accurate typing and antimicrobial resistance profiling in Neisseria gonorrhoeae	21
Deamidation enables pathogenic SMAD6 variants to activate the BMP signaling pathway	20
Genomic analysis of modern maize inbred lines reveals diversity and selective breeding effects	20
PRC2 primes bivalent genes for transcription induction independent of histone methyltransferase activity	20
Intra-articular injection of stromal vascular fraction for knee degenerative joint disease: a concise review of preclinical and clinical evidence	20
CD146, a therapeutic target involved in cell plasticity	19
Genetic advancements and future directions in ruminant livestock breeding: from reference genomes to multiomics innovations	19
Distinct and shared endothermic strategies in the heat producing tissues of tuna and other teleosts	19
CARs: a new approach for the treatment of autoimmune diseases	19
The discovery of tiny RNAs that have crucial roles	19
Low-dose exposure to microplastics retards meiotic maturation via HDAC3 insufficiency	19
OsRLCK160 contributes to flavonoid accumulation and UV-B tolerance by regulating OsbZIP48 in rice	19
Transient chemical-mediated epigenetic modulation confers unrestricted lineage potential on human primed pluripotent stem cells	19
Plant metabolism paves the way for breeding crops with high nutritional value and stable yield	19
Overcoming genotypic dependency and bypassing immature embryos in wheat transformation by using morphogenic regulators	19
Early changes to the extracellular space in the hippocampus under simulated microgravity conditions	18
The TFIID pivot of preinitiation complex	17
When smoke meets gut: deciphering the interactions between tobacco smoking and gut microbiota in disease development	17
Mapping and analysis of a spatiotemporal H3K27ac and gene expression spectrum in pigs	17
Occurrence and distribution of geminiviruses in China	17
Integrating spatial transcriptomics and single-nucleus RNA-seq revealed the specific inhibitory effects of TGF-β on intramuscular fat deposition	17
Low-dose lactate promotes neuroinflammation and induces the side effect of colitis	17
The effect of SARS-CoV-2 infection on human embryo early development: a multicenter prospective cohort study	17
Identification and validation of key biomarkers and potential therapeutic targets for primary open-angle glaucoma	17
Compound muscle action potential (CMAP) scan examination of paretic and contralateral muscles reveals motor unit alterations after stroke	17
Atmospheric humidity regulates same-sex mating in Candida albicans through the trehalose and osmotic signaling pathways	17
Screening and identification of HLA-A2-restricted neoepitopes for immunotherapy of non-microsatellite instability-high colorectal cancer	17
The spatial transcriptomic landscape of human gingiva in health and periodontitis	16
Profile of Dr. Shaorong Gao	16
Antithetical impacts of deleterious LRP1B mutations in non-squamous and squamous NSCLCs on predicting benefits from immune checkpoint inhibitor alone or with chemotherapy over chemotherapy alone: retr	16
Wheat stripe rust resistance gene Yr9, derived from rye, is a CC-NBS-LRR gene in a highly conserved NLR cluster	16
Cryo-EM structures reveal the dynamic transformation of human alpha-2-macroglobulin working as a protease inhibitor	16
Advances in regulation and function of stearoyl-CoA desaturase 1 in cancer, from bench to bed	16
Efficient generation of all ESC-derived mice carrying a homozygous lethal mutation through eight-cell embryo injection	16
Zooming on T cells in cancer	16
Diversity and connectedness of brine shrimp viruses in global hypersaline ecosystems	16
Techniques for increasing the yield of stem cell-derived exosomes: what factors may be involved?	16
GLA deficiency causes cardiac hypertrophy via enhanced autophagy	16
LPS-related muscle loss is associated with the alteration of Bacteroidetes abundance, systemic inflammation, and mitochondrial morphology in a weaned piglet model	16
Innate and adaptive immune abnormalities underlying autoimmune diseases: the genetic connections	15
Developing a robust genome editing tool based on an endogenous type I-B CRISPR-Cas system in Saccharopolyspora spinosa	15
Rice GWAS-to-Gene uncovers the polygenic basis of traits	15
Individual and joint exposures to PM2.5 constituents and mortality risk among the oldest-old in China	15
Profile of Dr. Jiaojun Zhu	15
Decoupled responses of soil microbial diversity and ecosystem functions to successive degeneration processes in alpine pioneer community	15
Nucleolar stress promotes and cooperates with ferroptosis to suppress cancer growth	15
m6A modification of plant virus enables host recognition by NMD factors in plants	15
Strategic codon selection for enhanced genetic code expansion	15
Enhancing whole yeast genome rearrangements through multiple LoxPsym sequences	15
Autophagy mediates a direct synergistic interaction during co-transmission of two distinct arboviruses by insect vectors	15
Huangjing (Polygonati rhizoma) is an emerging crop with great potential to fight chronic and hidden hunger	15
A paternal protein facilitates sperm RNA delivery to regulate zygotic development	15
G9a/GLP catalyzes H3K14me1 and H3K14me2 in vivo and in vitro	15
Identification of EPOR and JAK2 double heterozygous variants in twin cases with familial erythrocytosis	15

A twist in the tale: global insights into archaeal box C/D RNA-guided 2′-O-methylation	15
Ultrasound-induced biophysical effects in controlled drug delivery	14
TIP60 acetylation of Bub1 regulates centromeric H2AT120 phosphorylation for faithful chromosome segregation	14
Structure of a histone hexamer bound by the chaperone domains of SPT16 and MCM2	14
Overview of SARS-CoV-2 genome-encoded proteins	14
Understanding the “SMART” features of hematopoietic stem cells and beyond	14
Loop CD20/CD19 CAR-T cells eradicate B-cell malignancies efficiently	14
Cracking the chitin code: how a single pair of LysM receptors deciphers symbiosis and immunity in Marchantia	14
The relative and combined effects of herbivore assemblage and soil nitrogen on plant diversity	14
SUB1 promotes colorectal cancer metastasis by activating NF-κB signaling via UBR5-mediated ubiquitination of UBXN1	14
Harnessing the Streptomyces-originating type I-E CRISPR/Cas system for efficient genome editing in Streptomyces	14
Mechanical transmission enables EMT cancer cells to drive epithelial cancer cell migration to guide tumor spheroid disaggregation	14
Potential oligonucleotide drugs in Bencao sRNA Atlas	13
SETD3-mediated histidine methylation of MCM7 regulates DNA replication by facilitating chromatin loading of MCM	13
Distant cousins come to ABP1’s rescue	13
MYC promotes global transcription in part by controlling P-TEFb complex formation via DNA-binding independent inhibition of CDK9 SUMOylation	13
Autoinhibition and cofactors of a helper NLR	13
Yield and quality properties of silage maize and their influencing factors in China	13
Plant synthetic epigenomic engineering for crop improvement	13
Effector modularity promotes functional diversification and evolutionary processes	13
Redox-stress response resistance (RRR) mediated by hyperoxidation of peroxiredoxin 2 in senescent cells	13
Unraveling the origins of PGY-sRNA-6, BZL-sRNA-20, and XKC-sRNA-h3	13
Applications and grants of the National Natural Science Foundation of China’s General Program and Young Scientists Fund in immunology research: a 10-year review (2013–2022)	13
Treating incurable non-communicable diseases by targeting iron metabolism and ferroptosis	13
A novel β2-AR agonist, Higenamine, induces β-arrestin-biased signaling	13
Transformation of cognition from mechanical to biological aqueous outflow pump may be a breakthrough in solving the problem of intraocular pressure regulation in glaucoma	13
Functional characterization of novel NPRL3 mutations identified in three families with focal epilepsy	12
Global multifaceted biodiversity patterns, centers, and conservation needs in angiosperms	12
From oral structure to molecular evidence: new insights into the evolutionary phylogeny of the ciliate order Sessilida (Protista, Ciliophora), with the establishment of two new families and new contri	12
Computer-aided engineering of CRISPR-Cas proteins for enhanced human genome editing	12
Whole grain black rice: a paradigm shift from mainly calories to a nutritious food that benefits human health	12
Viromes in marine ecosystems reveal remarkable invertebrate RNA virus diversity	12
Exploring the R-ISS stage-specific regular networks in the progression of multiple myeloma at single-cell resolution	12
Linking circular intronic RNA degradation and function in transcription by RNase H1	12
Recent advances in RNA structurome	12
Local field potentials, spiking activity, and receptive fields in human visual cortex	12
Prioritization of risk genes in colorectal cancer by integrative analysis of multi-omics data and gene networks	12
Functional microglia derived from human pluripotent stem cells empower retinal organs	12
Reversing anther thermotolerance by manipulating the cis-elements in the promoter of a high-temperature upregulated gene Casein Kinase I in upland cotton	11
Structural characterization of SARS-CoV-2 dimeric ORF9b reveals potential fold-switching trigger mechanism	11
An improved hybrid bream derived from a hybrid lineage of Megalobrama amblycephala (♀)×Culter alburnus (♂)	11
Combined effects of climate and land-use changes on the alpha and beta functional diversities of terrestrial mammals in China	11
The repression of oncoprotein SET by the tumor suppressor p53 reveals a p53-SET-PP2A feedback loop for cancer therapy	11
Recent advances in tissue stem cells	11
Benyuan Charity Fund-Young Investigator Exploration Award	11
Amino acids TORC (talk) to anabolism through uncharged tRNA	11
Sequencing and characterizing human mitochondrial genomes in the biobank-based genomic research paradigm	11
Cucumber green mottle mosaic virus encodes additional small proteins with specific subcellular localizations and virulence function	11
DDX21 is a new player in co-transcriptional RNA modification and functions	11
A widespread response of Gram-negative bacterial acyl-homoserine lactone receptors to Gram-positive Streptomyces γ-butyrolactone signaling molecules	11
Generation of transient totipotent blastomere-like stem cells by short-term high-dose Pladienolide B treatment	11
The role of corneal endothelium in macular corneal dystrophy development and recurrence	11
Extracellular vesicles in cancer progression: mechanisms and significance	11
Crosstalk between brassinosteroid signaling and variable nutrient environments	11
Dietary iron regulates intestinal goblet cell function and alleviates Salmonella typhimurium invasion in mice	11
Birth-and-death evolution of ribonuclease 9 genes in Cetartiodactyla	11
A new era of mass data storage in artificial chromosome	11
Molecular mechanisms of DNA lesion and repair during antibody somatic hypermutation	11
A strategy for the development of receptor-containing antibodies targeting malaria variant surface antigens	11
Truncated glycoprotein E of varicella-zoster virus is an ideal immunogen for Escherichia coli-based vaccine design	11
Genome-wide signatures of the geographic expansion and breeding of soybean	11
A urinary proteomic landscape of COVID-19 progression identifies signaling pathways and therapeutic options	10
FishSCT: a zebrafish-centric database for exploration and visualization of fish single-cell transcriptome	10
Local administration of liposomal-based Plekhf1 gene therapy attenuates pulmonary fibrosis by modulating macrophage polarization	10
Differences in intestinal microbiome are associated with the mortality of COVID-19 patients in intensive care units	10
Promotion of Arabidopsis immune responses by a rhizosphere fungus via supply of pipecolic acid to plants and selective augment of phytoalexins	10
Single-base resolution mapping of 2′-O-methylation sites by an exoribonuclease-enriched chemical method	10
Assessing the ecological effects of the World’s Largest Forestry Eco-engineering: Three-North Protective Forest Program within the initially scheduled range from 1978 to 2022	10
SLC39A10 is a key zinc transporter in T cells and its loss mitigates autoimmune disease	10
High-density lipoprotein regulates angiogenesis by affecting autophagy via miRNA-181a-5p	10
Unravelling the genetic basis for skeletal muscle mitochondrial DNA copy number variations in pigs	10
Erratum to: Developmental recording of the ghost-moth larvae after ex situ infection by Ophiocordyceps sinensis	10
The patterns and participants of parental histone recycling during DNA replication in Saccharomyces cerevisiae	10
Convergent patterns in multitrophic biodiversity effects on yield across ecosystems	10
Bactericidal bissulfone B7 targets bacterial pyruvate kinase to impair bacterial biology and pathogenicity in plants	10
Base editor-mediated large-scale screening of functional mutations in bacteria for industrial phenotypes	10
Adult-repopulating lymphoid potential of yolk sac blood vessels is not confined to arterial endothelial cells	10
Embracing the age of artificial intelligence: paradigm shifts, opportunities, and challenges in the treatment of acute graft-versus-host disease after allogeneic hematopoietic stem cell transplantatio	10
Sex-biased adaptation shapes uniparental gene pools in Tibetans	10
Facing small and biased data dilemma in drug discovery with enhanced federated learning approaches	10
DEtail-seq is an ultra-efficient and convenient method for meiotic DNA break profiling in multiple organisms	10
Ihog proteins contribute to integrin-mediated focal adhesions	10
Development of regenerative therapies targeting fibrotic endometrium in intrauterine adhesion or thin endometrium to restore uterine function	10
A comprehensive review on natural phenolic compounds as alternatives to in-feed antibiotics	10
Progress in immunotherapy	10
Cross-species binding spectrum of ACE2 to SARS-CoV-2 RBD	10
Integrated medical resource consumption stratification in hospitalized patients: an Auto Triage Management model based on accurate risk, cost and length of stay prediction	10