Science China-Life Sciences

Article	Citations
What the genome of the leafy seadragon teaches us about rapid evolution of camouflage and adaptations to life in the kelp forest	359
New insights from a plant immune receptor may help design of disease resistant crops	341
Nanowire-mediated miRNA delivery	189
Convergent and conserved roads lead to Rome: now archaea fill the gap of transcription termination	167
Dissecting the cell microenvironment of ovarian endometrioma through single-cell RNA sequencing	163
Toward a comprehensive map of Rab-mediated cargo transport to migrasomes	150
Advances in genotypic antimicrobialresistance testing: a comprehensive review	139
A neighboring NLR negatively regulates the wheat broad-spectrum resistance protein encoded by Pm21	137
Unveiling potential sex-determining genes and sex-specific markers in autotetraploid Carassius auratus	131
Enlarged fins of Tibetan catfish provide new evidence of adaptation to high plateau	112
Cytokines-activated nuclear IKKα-FAT10 pathway induces breast cancer tamoxifen-resistance	106
Pseudo-chromosome—length genome assembly for a deep-sea eel Ilyophis brunneus sheds light on the deep-sea adaptation	102
Vibration mechanics involved in buzz pollination lead to size-dependent associations between bumblebees and Pedicularis flowers	96
Dietary carbohydrate intake and risk of type 2 diabetes: a 16-year prospective cohort study	87
Chemical adaptation: bridging synthetic chemistry with drug development	74
Inhibition of KDM6B prevents osteoarthritis by blocking growth plate-like H3K27me3 loss in bivalent genes	71
Loss of Tet hydroxymethylase activity causes mouse embryonic stem cell differentiation bias and developmental defects	70
Quantitative characterization of filamentous fungal promoters on a single-cell resolution to discover cryptic natural products	66
Microbe-induced gene silencing explores interspecies RNAi and opens up possibilities of crop protection	63
The genetic basis and process of inbreeding depression in an elite hybrid rice	62
TRAD: a functional annotation resource for human tandem repeats	59
Danhong Injection targets CaMKII through Dihydrotanshinone I to alleviate cardiomyocyte death and inflammation in viral myocarditis	58
m6A reader YTHDF2 governs the onset of atrial fibrillation by modulating Cacna1c translation	56
Genetic mutations across multiple pathways drive filamentous growth and virulence in the emerging fungal pathogen Candida auris	55
RNA ac4C modification in cancer biology: from regulatory mechanisms to clinical applications	53

Integration of perioperative features and intragraft TCF7L2 expression to predict lipid metabolic disorder in liver transplant recipients	53
Green manuring relocates microbiomes in driving the soil functionality of nitrogen cycling to obtain preferable grain yields in thirty years	53
FHL2 deficiency aggravates Candida albicans infection through decreased myelopoiesis	52
NAP-seq: unveiling the hidden world of noncapped RNAs	51
Enlarged DNA unwinding by Nme2Cas9 permits a broadened base editing window beyond the protospacer	51
Unraveling the diversity of bile acid modifications by integrative mass spectrometry approaches	50
PanSci: decoding panoramas of ageing	49
Interplant communication: an emerging battlefield in plant-aphid-virus interactions	48
Precision regulation of plant aromatic amino acid homeostasis	47
Multi-omics study reveals a light-dependent regulatory network of flavonoid biosynthesis in lettuce (Lactuca sativa L.)	46
Host-microbial co-regulation mediates rumen volatile fatty acid production and utilization in dairy cows	44
Integrative analysis based on CRISPR screen identifies apilimod as a potential therapeutic agent for cisplatin-induced acute kidney injury treatment	42
TEDD 2.0: an advanced temporal gene expression database enabled by in-silico functional analyses for developmental mechanism investigation	42
Mobile ARGONAUTE 1d binds 22-nt miRNAs to generate phasiRNAs important for low-temperature male fertility in rice	42
Critical roles of non-coding RNAs in lifecycle and biology of Marek’s disease herpesvirus	42
Secretory NS1’ protein of orthoflavivirus promotes viral transmission to mosquitoes by suppressing the RNAi pathway	41
Systems metabolic engineering of Phaffia rhodozyma for ultra-high astaxanthin production through multiple strategies	41
A shared role of the myocardin-family transcriptional coactivators in cardiomyocyte maturation	41
Effect of SARS-CoV-2 infection in early pregnancy on placental development	40
Nematode-induced trap formation regulated by the histone H3K4 methyltransferase AoSET1 in the nematode-trapping fungus Arthrobotrys oligospora	39
Advances and applications in single-cell and spatial genomics	39
A neural m6A pathway regulates behavioral aggregation in migratory locusts	37
Targeting complement and coagulation cascades with Buyang Huanwu Decoction attenuates acute inflammation and enhances neuroprotection in spinal cord injury	37
The genomic and immunogenomic landscape of mechanics pathway informs clinical prognosis and response to mechanotherapy	37
Ginsenoside Rb1 inhibits oxidative stress-induced ovarian granulosa cell injury through Akt-FoxO1 interaction	36
An artificial immune switch system: engineering durable, broad-spectrum disease resistance in plants	36
Phase separation of a master transcription factor targeted by a natural compound regulates fungal ergosterol homeostasis	36
Plant and fungal species interactions differ between aboveground and belowground habitats in mountain forests of eastern China	35
Cereal-legume intercropping stimulates straw decomposition and promotes soil organic carbon stability	34
Activating the cGAS-STING pathway in hypoxic microenvironment: blocking ADSL’s ER localization	34
Nicotinamide prevents anti-PD1 immune checkpoint inhibitor-associated early stages of cardiotoxicity	34
Low-affinity SPL binding sites contribute to subgenome expression divergence in allohexaploid wheat	34
Development of modern medicine 4.0: the impact and enlightenment of the Industrial Revolution	33
Predicting Lactobacillus delbrueckii subsp. bulgaricus-Streptococcus thermophilus interactions based on a highly accurate semi-supervised learning method	33
Human TRMT1 catalyzes m2G or m22G formation on tRNAs in a substrate-dependent manner	33
Attenuation of plant immune kinases by U-box type E3 ubiquitin ligases	33
Nitrogen addition promotes soil carbon accumulation globally	33
WTAP mediated m6A methylation modulates retinal photoreceptor function via facilitating of REEP6, PDE6B and RDH12 translation	32
CRISPR screening identifies protein methylation and ubiquitination modifications that modulate aflatoxin B1 cytotoxicity	32
Longitudinal plasma proteomic evidence linking SARS-CoV-2 infection to increased β-amyloid pathology	32
HIV encephalopathy is contributed by macrophages and microglia	32
From modeling to therapy: the efficient and precise tools for mitochondrial base editing	31
Piceatannol enhances Beclin-1 activity to suppress tumor progression and its combination therapy strategy with everolimus in gastric cancer	31
RIVER delivers multimodal gene-directed regulatory interactions across diverse biological contexts with broad application potentials	31
Explore the nucleolus: unveiling the hidden layer with super-resolution microscopy	30
Antibody-based targeted protein degradation for membrane and extracellular proteins: emerging strategies and breakthroughs	30
Priming crops for heat stress with prime editing	30
Natural polymorphisms of COOL1 contribute to cold tolerance adaptation in maize	30
Upgraded durian genome reveals the role of chromosome reshuffling during ancestral karyotype evolution, lignin biosynthesis regulation, and stress tolerance	29
Enhancing sheepgrass through genomic exploration and targeted editing	29

Design of a novel chimeric peptide via dual blockade of CD47/SIRPα and PD-1/PD-L1 for cancer immunotherapy	29
Three-dimensional visualization of tip-vesicles in growing pollen tubes by electron tomography	29
Peripheral blood RNA modifications as a novel diagnostic signature for polycystic ovary syndrome	28
Altered 3D genome reorganization mediates precocious myeloid differentiation of aged hematopoietic stem cells in inflammation	28
Strategies and mechanisms for the enhancement of chimeric antigen receptor T-cell functions	28
IVSA-based siRNA targeted delivery system as a universal strategy for the treatment of EGFR-positive cancer	28
Versatile plant genome engineering using anti-CRISPR-Cas12a systems	28
Protein foundation models: a comprehensive survey	28
The vinculin-β-catenin axis promotes bone formation and repair: an essential prerequisite for the anti-osteoporotic efficacy of sclerostin-neutralizing antibody	27
Analysis of non-coding small RNA similarity/sharing between plant and animal genomes	27
Decoding the fish genome opens a new era in important trait research and molecular breeding in China	27
SPHK1 deficiency promotes intestinal homeostasis by ameliorating ER stress-induced gastrointestinal injury during murine graft-versus-host disease	27
Animal burrows as critical thermal refuges in the age of climate change	27
Cell-specific gene expression plasticity in response to hypoxia promotes high-altitude adaptive evolution	27
Redox state of NAD modulates the activation of Na-bicarbonate cotransporter NBCe1-B via IRBIT and L-IRBIT	27
Chemical defense mediates population density-driven on anuran brain size evolution	27
Activating translation by phase separation: a novel mechanism for driving spermiogenesis	26
Potential oligonucleotide drugs in Bencao sRNA Atlas (II)	26
Building the Chordata Olfactory Receptor Database using more than 400,000 receptors annotated by Genome2OR	26
RNA modifications: bridging the gap between molecular mechanisms and clinical applications	26
Lentiviral vectors for gene therapy of α-thalassemia	25
PIWI-specific insertion module: a newly identified regulatory element essential for longer piRNAs loading and male fertility	25
Erratum to: Local administration of liposomal-based Plekhf1 gene therapy attenuates pulmonary fibrosis by modulating macrophage polarization	24
Erratum to: A thorough analysis of diabetes research in China from 1995 to 2015: current scenario and future scope	24
A hidden translatome in tumors—the coding lncRNAs	23
A new model system for cotton indoor genetic and genomic research	23
Tree of life and conservation of gymnosperms in China	23
Targeting LTA4H facilitates the reshaping of the immune microenvironment mediated by CCL5 and sensitizes ovarian cancer to Cisplatin	23
Whole-grain black rice diet rewires the single-cell transcriptomic landscape of age-related ovarian decline in mice	23
Nitrogen addition and mowing alter drought resistance and recovery of grassland communities	23
Gene-knockout by iSTOP enables rapid reproductive disease modeling and phenotyping in germ cells of the founder generation	23
An iron-dependent form of non-canonical ferroptosis induced by labile iron	23
Crop antiviral defense: Past and future perspective	23
Hot breath, quick exit: aphids flee mammalian heat via TRPA1	22
The OsRqc1-OsVms1 module regulates the temperature threshold in thermo-sensitive genic male-sterile rice lines	22
Distinct roles of H3K27me3 and H3K36me3 in vernalization response, maintenance, and resetting in winter wheat	22
PDGFR kinase inhibitor protects against septic death via regulation of BTLA	22
LncRNA CFAR promotes cardiac fibrosis via the miR-449a-5p/LOXL3/mTOR axis	22
In-depth urinary and exosome proteome profiling analysis identifies novel biomarkers for diabetic kidney disease	22
Green revolution gene drives adaptation of Arabidopsis to the extremely high altitude	22
Light-at-night exposure drives myopia via melanopsin signalling	22
Evolutionarily conserved mucus-mediated nanoplastic bioflocculation in Tetrahymena	22
Distinct and shared endothermic strategies in the heat producing tissues of tuna and other teleosts	21
Optimized inner ear organoids for efficient hair cell generation and ototoxicity response modeling	21
Overcoming genotypic dependency and bypassing immature embryos in wheat transformation by using morphogenic regulators	21
Transient chemical-mediated epigenetic modulation confers unrestricted lineage potential on human primed pluripotent stem cells	21
A synthetic microbial community used as a bioinoculant can overcome rice production constraints in acid soils	21
Genomic analysis of modern maize inbred lines reveals diversity and selective breeding effects	21
Identification and validation of key biomarkers and potential therapeutic targets for primary open-angle glaucoma	21
Ribo-seq provides additional evidence for cytoplasm-translated mitochondrial DNA-encoded ORFs	21
Gut microbiome and postbiotics: bridging the dietary nutrition and feed efficiency in food-producing animals	21
Deamidation enables pathogenic SMAD6 variants to activate the BMP signaling pathway	21
Neural identification of self-emitted vocalizations in the auditory midbrain of behaving bats	20
Pre-disease State perspective in life & health interdisciplinary research	20
PRC2 primes bivalent genes for transcription induction independent of histone methyltransferase activity	20
CARs: a new approach for the treatment of autoimmune diseases	20
Development and performance evaluation of a culture-independent nanopore amplicon-based sequencing method for accurate typing and antimicrobial resistance profiling in Neisseria gonorrhoeae	20
ESIRA, a novel framework integrating efficacy and safety for evaluating first-line treatments in advanced hepatocellular carcinoma	20
CD146, a therapeutic target involved in cell plasticity	20
Low-dose exposure to microplastics retards meiotic maturation via HDAC3 insufficiency	19
Transfer RNA-derived small RNA-Gly activates the ACPH/GRHL1 axis to facilitate liver cell regeneration in acute-on chronic liver failure	19
Occurrence and distribution of geminiviruses in China	19
Compound muscle action potential (CMAP) scan examination of paretic and contralateral muscles reveals motor unit alterations after stroke	19
Efficient generation of all ESC-derived mice carrying a homozygous lethal mutation through eight-cell embryo injection	19
Genetic advancements and future directions in ruminant livestock breeding: from reference genomes to multiomics innovations	19
The discovery of tiny RNAs that have crucial roles	19
Multi-omic analysis of the liver-breast axis reveals key hepatic mediators of breast cancer progression	19
Nucleolar stress promotes and cooperates with ferroptosis to suppress cancer growth	19
STAT3 suppresses palmitic acid-induced apoptosis and fatty acid oxidation dysfunction in bovine mammary epithelial cells by transcriptionally activating CPT1A	19
Galacto-oligosaccharides enrich galactosidase-encoded rather than all Lachnospiraceae bacteria to redress abnormal gut microbiota and lipid metabolism in pregnancy	19
Profile of Dr. Shaorong Gao	19
Advances in regulation and function of stearoyl-CoA desaturase 1 in cancer, from bench to bed	19
Antithetical impacts of deleterious LRP1B mutations in non-squamous and squamous NSCLCs on predicting benefits from immune checkpoint inhibitor alone or with chemotherapy over chemotherapy alone: retr	19
GLA deficiency causes cardiac hypertrophy via enhanced autophagy	18
When smoke meets gut: deciphering the interactions between tobacco smoking and gut microbiota in disease development	18
The spatial transcriptomic landscape of human gingiva in health and periodontitis	18
The effect of SARS-CoV-2 infection on human embryo early development: a multicenter prospective cohort study	18
LPS-related muscle loss is associated with the alteration of Bacteroidetes abundance, systemic inflammation, and mitochondrial morphology in a weaned piglet model	18
Cell-supporting cytoskeletons and phagocytic acquisition of compatible solutes emerge as common strategies for high-salt adaptation in different ciliates	18
A paternal protein facilitates sperm RNA delivery to regulate zygotic development	18

m6A modification of plant virus enables host recognition by NMD factors in plants	18
Decoupled responses of soil microbial diversity and ecosystem functions to successive degeneration processes in alpine pioneer community	18
Innate and adaptive immune abnormalities underlying autoimmune diseases: the genetic connections	18
Vesicle-mediated intercellular communication	18
Low-dose lactate promotes neuroinflammation and induces the side effect of colitis	18
Comprehensive metabolic profiling uncovers early variation and biomarkers of esophageal squamous cell carcinoma	18
Rice OsMKK6-OsMPK4 cascade regulates endosperm cellularization via Polycomb Repressive Complex 2	18
Atmospheric humidity regulates same-sex mating in Candida albicans through the trehalose and osmotic signaling pathways	18
Integrating spatial transcriptomics and single-nucleus RNA-seq revealed the specific inhibitory effects of TGF-β on intramuscular fat deposition	18
Rice GWAS-to-Gene uncovers the polygenic basis of traits	18
Autophagy mediates a direct synergistic interaction during co-transmission of two distinct arboviruses by insect vectors	18
Cryo-EM structures reveal the dynamic transformation of human alpha-2-macroglobulin working as a protease inhibitor	17
Wheat stripe rust resistance gene Yr9, derived from rye, is a CC-NBS-LRR gene in a highly conserved NLR cluster	17
Profile of Dr. Jiaojun Zhu	17
Evolution of drug classification, target distribution, and introduction of novel antidepressants in China	17
Identification of EPOR and JAK2 double heterozygous variants in twin cases with familial erythrocytosis	17
Diversity and connectedness of brine shrimp viruses in global hypersaline ecosystems	17
A new regulatory axis in cross-presentation: MS4A7 licenses cDC1s for effective CD8+ T-cell priming	17
Enhancing whole yeast genome rearrangements through multiple LoxPsym sequences	17
AtLYK4 is the major chitin receptor in Arabidopsis with N-glycosylation and ligand-interacting residues orchestrating chitin perception	17
A twist in the tale: global insights into archaeal box C/D RNA-guided 2′-O-methylation	17
Multifactorial and multiplexed epigenomic profiling of five DNA modifications in plants with mDIP-seq	17
Developing a robust genome editing tool based on an endogenous type I-B CRISPR-Cas system in Saccharopolyspora spinosa	17
Plant synthetic epigenomic engineering for crop improvement	16
Strategic codon selection for enhanced genetic code expansion	16
Potential oligonucleotide drugs in Bencao sRNA Atlas	16
TIP60 acetylation of Bub1 regulates centromeric H2AT120 phosphorylation for faithful chromosome segregation	16
GhDREB1B-GhFAD3-2 module mediates drought tolerance by regulating linolenic acid biosynthesis in cotton	16
Single-nucleus RNA sequencing reveals the underlying roadmap of early gonadal differentiation in teleost	16
Harnessing the Streptomyces-originating type I-E CRISPR/Cas system for efficient genome editing in Streptomyces	16
Cracking the chitin code: how a single pair of LysM receptors deciphers symbiosis and immunity in Marchantia	16
Morphological and physiological responses to aridity in narrowly- and widely-distributed plant species in drylands	16
MtLICK1/2: gatekeepers of symbiosis and immunity in Medicago truncatula	16
Individual and joint exposures to PM2.5 constituents and mortality risk among the oldest-old in China	16
Broad synergistic effects of an AMP with multiple antibiotics against drug-resistant bacteria via multifaceted mechanisms	16
Unraveling the origins of PGY-sRNA-6, BZL-sRNA-20, and XKC-sRNA-h3	16
Structure of a histone hexamer bound by the chaperone domains of SPT16 and MCM2	15
Autoinhibition and cofactors of a helper NLR	15
Effector modularity promotes functional diversification and evolutionary processes	15
ASCENT: an active transfer learning paradigm for efficient drug-target interaction prediction	15
Mitophagy activation for jawbone radiation injury therapy via angiogenesis/osteogenesis-active nanozymes	15
Applications and grants of the National Natural Science Foundation of China’s General Program and Young Scientists Fund in immunology research: a 10-year review (2013–2022)	15
Loop CD20/CD19 CAR-T cells eradicate B-cell malignancies efficiently	15
Increased virulence and decreased antimicrobial resistance in Klebsiella pneumoniae in Beijing since 2020: a retrospective molecular epidemiology study	15
SUB1 promotes colorectal cancer metastasis by activating NF-κB signaling via UBR5-mediated ubiquitination of UBXN1	15
Enhancement of in vitro transcribed (IVT) mRNA translation efficiency through engineered poly(A) tails	15
From oral structure to molecular evidence: new insights into the evolutionary phylogeny of the ciliate order Sessilida (Protista, Ciliophora), with the establishment of two new families and new contri	15
MYC promotes global transcription in part by controlling P-TEFb complex formation via DNA-binding independent inhibition of CDK9 SUMOylation	15
Deubiquitinases in liver diseases: from mechanisms to targeted therapy	14
Computer-aided engineering of CRISPR-Cas proteins for enhanced human genome editing	14
Progress and gaps in antimicrobial resistance research within One Health sectors in China: a systematic analysis	14
Reversing anther thermotolerance by manipulating the cis-elements in the promoter of a high-temperature upregulated gene Casein Kinase I in upland cotton	14
Negative edge effects on forest carbon stocks in China: an estimate based on inventory data	14
Erratum to: FSIP1 enhances the therapeutic sensitivity to CDK4/6 inhibitors in triple-negative breast cancer patients by activating the Nanog pathway	14
Functional characterization of novel NPRL3 mutations identified in three families with focal epilepsy	14
Publisher Correction to: The light and hypoxia induced gene ZmPORB1 determines tocopherol content in the maize kernel	14
Transformation of cognition from mechanical to biological aqueous outflow pump may be a breakthrough in solving the problem of intraocular pressure regulation in glaucoma	14
Chromatin accessibility landscape during mammalian preimplantation development	14
Distant cousins come to ABP1’s rescue	14
Approaching the perfection of natural enzymes: evolution of biomimetic catalytic systems	14
Treating incurable non-communicable diseases by targeting iron metabolism and ferroptosis	14
Biosynthesis of melanin from lignin hydrolysates by metabolically engineered Cupriavidus necator	14
The theory of the inflammatory ecosystem	13
Recent advances in RNA structurome	13
Whole grain black rice: a paradigm shift from mainly calories to a nutritious food that benefits human health	13
SETD3-mediated histidine methylation of MCM7 regulates DNA replication by facilitating chromatin loading of MCM	13
Cucumber green mottle mosaic virus encodes additional small proteins with specific subcellular localizations and virulence function	13
Exploring primate immune responses to SLA-I/II knockdown pig xenografts in humanized mice and rhesus monkeys	13
The repression of oncoprotein SET by the tumor suppressor p53 reveals a p53-SET-PP2A feedback loop for cancer therapy	13
Amino acids TORC (talk) to anabolism through uncharged tRNA	13
Functional cancer-cell-nociceptive neuronal circuits drive gastric tumor progression	13
Crosstalk between brassinosteroid signaling and variable nutrient environments	13
Structural characterization of SARS-CoV-2 dimeric ORF9b reveals potential fold-switching trigger mechanism	13
Prioritization of risk genes in colorectal cancer by integrative analysis of multi-omics data and gene networks	13
Redox-stress response resistance (RRR) mediated by hyperoxidation of peroxiredoxin 2 in senescent cells	13
Automatic quantification, grading and five-year prediction of myopic fundus tessellation: a multi-center, longitudinal deep learning study	13
Birth-and-death evolution of ribonuclease 9 genes in Cetartiodactyla	13
Sequencing and characterizing human mitochondrial genomes in the biobank-based genomic research paradigm	13
Local field potentials, spiking activity, and receptive fields in human visual cortex	13
Global multifaceted biodiversity patterns, centers, and conservation needs in angiosperms	13
Transcriptome-wide identification of glycoRNAs by Clier-seq pipeline	13
Dietary iron regulates intestinal goblet cell function and alleviates Salmonella typhimurium invasion in mice	13
Microbial bile acid modifications: current understandings, key problems, and future perspectives	13
Dual phosphorylation of DISC1 at Ser58 and Ser713 regulates polarization of cortical neurons via GSK3β	13
DDX21 is a new player in co-transcriptional RNA modification and functions	13
Single-base resolution mapping of 2′-O-methylation sites by an exoribonuclease-enriched chemical method	12
Intergenerational dialogue via the gut microbiome and breast milk	12
The patterns and participants of parental histone recycling during DNA replication in Saccharomyces cerevisiae	12
Generation of transient totipotent blastomere-like stem cells by short-term high-dose Pladienolide B treatment	12
Innovative D-peptide strategy for targeting tau fibrils in Alzheimer’s disease	12
Base editor-mediated large-scale screening of functional mutations in bacteria for industrial phenotypes	12
Extracellular vesicles in cancer progression: mechanisms and significance	12
CassavaMDB: an integrated multi-omics database for functional genomics and molecular breeding in cassava	12
Imaging-guided non-invasive in vivo acoustic printing: a new “surgery-as-printing” paradigm for precision medicine	12
The role of corneal endothelium in macular corneal dystrophy development and recurrence	12