OOIR: Observatory of International Research

Papers

(The median citation count of Protein & Cell is 2. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-04-01 to 2025-04-01.)

Article	Citations
Oncomicrobial vaccines mitigate tumor progression via precisely targeting oncomicrobes in mice	292
Unfolding HBx for an epigenetic switch of HBV cccDNA minichromosome	156
IL-24 promotes atopic dermatitis-like inflammation through driving MRSA-induced allergic responses	124
Metabolic cell death in cancer: ferroptosis, cuproptosis, disulfidptosis, and beyond	112
“Always learn today, stand ready to act tomorrow”—Po Tien: A pioneer of Virology in China	104
The Host Microbiota is Associated with the Occurrence and Development of Esophageal Squamous Cell Carcinoma	101
Ko Kuei Chen: A Pioneer of Modern Pharmacological Research in China	83
In memory of the well-renowned Chinese cellular biologist Shien Sher-Pu	74
Single-cell analysis reveals an Angpt4-initiated EPDC-EC-CM cellular coordination cascade during heart regeneration	55
Zhu Xi: A Pioneer of Experimental Biology	52
Cell-cycle length of medial ganglionic eminence progenitors contributes to interneuron fate	49
Dual role of lipids for genome stability and pluripotency facilitates full potency of mouse embryonic stem cells	46
Correction to: Oncogenic miR-19a and miR-19b co-regulate tumor suppressor MTUS1 to promote cell proliferation and migration in lung cancer	43
METTL14 is a chromatin regulator independent of its RNA N 6-methyladenosine methyltransferase activity	43
Jiangsen Mao: a pioneer in Chinese hepatitis A vaccine and interferon research, a virologist at the forefront of times	41
Targeting IRG1 in tumor-associated macrophages for cancer therapy	36
Gene print-based cell subtypes annotation of human disease across heterogeneous datasets with gPRINT	35
Architecture of severe fever with thrombocytopenia syndrome virus	33
Single-cell profiling reveals a potent role of quercetin in promoting hair regeneration	32
Isogenic human pluripotent stem cell disease models reveal ABRA deficiency underlies cTnT mutation-induced familial dilated cardiomyopathy	31
Gut microbial methionine impacts circadian clock gene expression and reactive oxygen species level in host gastrointestinal tract	26
Remembering the Scholar Ding Ying: The Father of Chinese Rice-Farming Science	25
Correction to: CRISPR/Cas9-mediated gene knockout reveals a guardian role of NF-κB/RelA in maintaining the homeostasis of human vascular cells	24
Bilineage embryo-like structure from EPS cells can produce live mice with tetraploid trophectoderm	24
Anthrax lethal toxin and tumor necrosis factor-α synergize on intestinal epithelia to induce mouse death	22

Asymmetric reconstruction of the aquareovirus core at near-atomic resolution and mechanism of transcription initiation	22
Microbiome research outlook: past, present, and future	22
A core epitope targeting antibody of SARS-CoV-2	21
DCK confers sensitivity of DCTD-positive cancer cells to oxidized methylcytidines	21
Resolving the lineage relationship between malignant cells and vascular cells in glioblastomas	20
Structural basis for polyuridine tract recognition by SARS-CoV-2 Nsp15	20
Boundless love: a German Professor Uli Schwarz in China	18
Spatially-resolved expression landscape and gene-regulatory network of human gastric corpus epithelium	18
Exploring unconventional attributes of red blood cells and their potential applications in biomedicine	18
Identification of FOXO1 as a geroprotector in human synovium through single-nucleus transcriptomic profiling	17
Aberrant outputs of cerebellar nuclei and targeted rescue of social deficits in an autism mouse model	17
Pan Shuh: the founding figure of modern Chinese psychology	17
An improved method for the detection of double-stranded RNA suitable for quality control of mRNA vaccines	16
Single-nucleus transcriptomics reveals a gatekeeper role for FOXP1 in primate cardiac aging	15
CRL3 E3 ligase regulates glutamine and cystine metabolisms	14
Richard Ho-Ping Sia: pioneer of infectiology in China	14
METTL9 mediated N1-histidine methylation of zinc transporters is required for tumor growth	13
Endoplasmic reticulum membrane remodeling by targeting reticulon-4 induces pyroptosis to facilitate antitumor immune	13
ARID1A IDR targets EWS-FLI1 condensates and finetunes chromatin remodeling	13
Persisting lung pathogenesis and minimum residual virus in hamster after acute COVID-19	13
Cancer biology deciphered by single-cell transcriptomic sequencing	12
Correction to: The nucleocapsid protein of rice stripe virus in cell nuclei of vector insect regulates viral replication	12
A third dose of inactivated vaccine augments the potency, breadth, and duration of anamnestic responses against SARS-CoV-2	12
Single-cell transcriptomic Atlas of mouse cochlear aging	11
MFSD12 affects glycosphingolipid metabolism by modulating lysosome homeostasis	11
Alzheimer’s disease: insights into pathology, molecular mechanisms, and therapy	11
Recent progress and challenges in the treatment of spinal cord injury	11
Sung Shu Chien: The founder of modern Chinese botany	11
JMJD1C forms condensate to facilitate a RUNX1-dependent gene expression program shared by multiple types of AML cells	11
Molecular deconvolution of the neutralizing antibodies induced by an inactivated SARS-CoV-2 virus vaccine	11
4E-BP1 counteracts human mesenchymal stem cell senescence via maintaining mitochondrial homeostasis	11
Maternal heterozygous mutation in CHEK1 leads to mitotic arrest in human zygotes	10
Two antibodies show broad, synergistic neutralization against SARS-CoV-2 variants by inducing conformational change within the RBD	10
Mechanistic insights into the GEF activity of the human MON1A/CCZ1/C18orf8 complex	10
Professor Delong Su: a pioneer in Schistosomiasis Eradication in China	10
Skeletal stem cells in bone development, homeostasis, and disease	9
Cryo-EM structures of Nipah virus polymerase complex reveal highly varied interactions between L and P proteins among paramyxoviruses	9
RBM46 is essential for gametogenesis and functions in post-transcriptional roles affecting meiotic cohesin subunits	8
CARM1 drives triple-negative breast cancer progression by coordinating with HIF1A	8
Follicle stimulating hormone controls granulosa cell glutamine synthesis to regulate ovulation	8
p21/Zbtb18 repress the expression of cKit to regulate the self-renewal of hematopoietic stem cells	8
Strategies for generating mouse model resources of human disease	8
Tanjun Tong: a pioneer of cellular senescence and aging mechanism research in China	8
Ferroptosis, radiotherapy, and combination therapeutic strategies	7
Microbiome, metabolome, and transcriptome analyses in esophageal squamous cell carcinoma: insights into immune modulation by F. nucleatum	7
Degeneration Directory: a multi-omics web resource for degenerative diseases	7
Suppression of USP8 sensitizes cells to ferroptosis via SQSTM1/p62-mediated ferritinophagy	7
Syn3, a newly developed cyclic peptide and BDNF signaling enhancer, ameliorates retinal ganglion cell degeneration in diabetic retinopathy	7
Lentivirus-modified hematopoietic stem cell gene therapy for advanced symptomatic juvenile metachromatic leukodystrophy: a long-term follow-up pilot study	7
A single-nucleus transcriptomic atlas of primate testicular aging reveals exhaustion of the spermatogonial stem cell reservoir and loss of Sertoli cell homeostasis	7

The Icarian flight of antibody-drug conjugates: target selection amidst complexity and tackling adverse impacts	7
Single-nucleus transcriptomics uncovers a geroprotective role of YAP in primate gingival aging	7
CRISPR-assisted transcription activation by phase-separation proteins	6
Mutations in the SARS-CoV-2 spike receptor binding domain and their delicate balance between ACE2 affinity and antibody evasion	6
A long non-coding RNA LncSync regulates mouse cardiomyocyte homeostasis and cardiac hypertrophy through coordination of miRNA actions	6
Single-nucleus transcriptomic landscape of primate hippocampal aging	6
IDDoR: A novel reporter mouse system for simultaneous and quantitative in vivo analysis of both DNA double-strand break repair pathways	6
Immunogenic molecules associated with gut bacterial cell walls: chemical structures, immune-modulating functions, and mechanisms	6
An ultrapotent pan-β-coronavirus lineage B (β-CoV-B) neutralizing antibody locks the receptor-binding domain in closed conformation by targeting its conserved epitope	6
Metformin activates chaperone-mediated autophagy and improves disease pathologies in an Alzheimer disease mouse model	6
Fan-lan Tai: A Pioneer of Plant Pathology and Mycology in China	6
Mechanism and design of allosteric activators of SIRT1	5
Correction to: EGFR signaling augments TLR4 cell surface expression and function in macrophages via regulation of Rab5a activation	5
Correction to: Modeling CADASIL vascular pathologies with patient-derived induced pluripotent stem cells	5
Nuclear m6A reader YTHDC1 regulates the scaffold function of LINE1 RNA in mouse ESCs and early embryos	5
Generation of developmentally competent oocytes and fertile mice from parthenogenetic embryonic stem cells	5
RECOLLECTION Hsien-wen Wu: A founder of the studies of Ichthyology in China	5
PINK1 kinase dysfunction triggers neurodegeneration in the primate brain without impacting mitochondrial homeostasis	5
Neutrophil extracellular traps license macrophage production of chemokines to facilitate CD8+ T cell infiltration in obstruction-induced renal fibrosis	5
Correction to: Low-dose chloroquine treatment extends the lifespan of aged rats	5
A molecular brake that modulates spliceosome pausing at detained introns contributes to neurodegeneration	4
The engagement of histone lysine methyltransferases with nucleosomes: structural basis, regulatory mechanisms, and therapeutic implications	4
Epigenetic integrity of paternal imprints enhances the developmental potential of androgenetic haploid embryonic stem cells	4
Correction to: Potentiating CD8+ T cell antitumor activity by inhibiting PCSK9 to promote LDLR-mediated TCR recycling and signaling	4
METTL9-catalyzed histidine methylation of S100A9 suppresses the anti-Staphylococcus aureus activity of neutrophils	4
Phosphorylation of NF2 at Serine-13 by MAP4K family kinases mediates pathological angiogenesis	4
Governing glutaminolysis by regulation of glutaminase succinylation	4
FOXO3-engineered human mesenchymal stem cells efficiently enhance post-ischemic stroke functional rehabilitation	4
mTORC2/RICTOR exerts differential levels of metabolic control in human embryonic, mesenchymal and neural stem cells	4
APOE-mediated suppression of the lncRNA MEG3 protects human cardiovascular cells from chronic inflammation	4
Remembering the scholar Ding Ying: the father of Chinese rice-farming science	4
Indiscriminate ssDNA cleavage activity of CRISPR-Cas12a induces no detectable off-target effects in mouse embryos	4
Sarm1-mediated neurodegeneration within the enteric nervous system protects against local inflammation of the colon	4
Correction to: Metformin activates chaperone-mediated autophagy and improves disease pathologies in an Alzheimer disease mouse model	4
Join the club: ORP8 is a lipophagy receptor	4
Dietary pyruvate targets cytosolic phospholipase A2 to mitigate inflammation and obesity in mice	3
Deciphering the placental abnormalities associated with somatic cell nuclear transfer at single-nucleus resolution	3
Pasteurized Akkermansia muciniphila promotes GP2 expression in microfold cells and facilitates Salmonella infection	3
Skin organoid transplantation promotes tissue repair with scarless in frostbite	3
Aging hallmarks of the primate ovary revealed by spatiotemporal transcriptomics	3
An orally-available monovalent SMAC mimetic compound as a broad-spectrum antiviral	3
Human ESC-derived vascular cells promote vascular regeneration in a HIF-1α dependent manner	3
PKM2, the “K+ sink” in the tumor interstitial fluid	3
The best practice for microbiome analysis using R	3
High-throughput single-microbe RNA sequencing reveals adaptive state heterogeneity and host-phage activity associations in human gut microbiome	3
Immune rebalancing at the maternal-fetal interface of maternal SARS-CoV-2 infection during early pregnancy	3
The chordata olfactory receptor database	3
Virological research history in China: a century of profiling virologists’ contributions and virological innovations	3
Emerging clinical relevance of microbiome in cancer: promising biomarkers and therapeutic targets	3
A hnRNPA2B1 agonist effectively inhibits HBV and SARS-CoV-2 omicronin vivo	3
A tribute to Professor Yong Zhao	2
Correction to: SIRT7 antagonizes human stem cell aging as a heterochromatin stabilizer	2
A YAP/TAZ-CD54 axis is required for CXCR2 −CD44 − tumor-specific neutrophils to suppress gastric cancer	2
Correction to: Enhancing prime editing efficiency and flexibility with tethered and split pegRNAs	2
Single-nucleus profiling unveils a geroprotective role of the FOXO3 in primate skeletal muscle aging	2
Ergothioneine and its congeners: anti-ageing mechanisms and pharmacophore biosynthesis	2
The exploration of N6-deoxyadenosine methylation in mammalian genomes	2
Structural insights into signal transduction of the purinergic receptors P2Y1R and P2Y12R	2
Structure basis for allosteric regulation of lymphocytic choriomeningitis virus polymerase function by Z matrix protein	2
Long-term in vivo chimeric cells tracking in non-human primate	2
Platelet RNA enables accurate detection of ovarian cancer: an intercontinental, biomarker identification study	2
High-throughput screening identifies established drugs as SARS-CoV-2 PLpro inhibitors	2
RNA helicase MTR4 drives tumorigenesis of nasopharyngeal carcinoma by regulating the expression of key cell cycle genes	2
Oxidative phosphorylation safeguards pluripotency via UDP-N-acetylglucosamine	2
Structural basis of INTAC-regulated transcription	2
High-throughput screening of SARS-CoV-2 main and papain-like protease inhibitors	2