OOIR: Observatory of International Research

Papers

(The median citation count of Protein & Cell is 3. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-08-01 to 2025-08-01.)

Article	Citations
“Always learn today, stand ready to act tomorrow”—Po Tien: A pioneer of Virology in China	164
Pan Shuh: the founding figure of modern Chinese psychology	157
Anthrax lethal toxin and tumor necrosis factor-α synergize on intestinal epithelia to induce mouse death	87
ARID1A IDR targets EWS-FLI1 condensates and finetunes chromatin remodeling	74
JMJD1C forms condensate to facilitate a RUNX1-dependent gene expression program shared by multiple types of AML cells	71
An improved method for the detection of double-stranded RNA suitable for quality control of mRNA vaccines	61
Architecture of severe fever with thrombocytopenia syndrome virus	61
Cancer biology deciphered by single-cell transcriptomic sequencing	60
Microbiome research outlook: past, present, and future	58
Endoplasmic reticulum membrane remodeling by targeting reticulon-4 induces pyroptosis to facilitate antitumor immune	52
DCK confers sensitivity of DCTD-positive cancer cells to oxidized methylcytidines	47
One step, two functions: the mechanism of the ABCH class of transporter serving barrier construction and detoxification in insects	46
Spatially-resolved expression landscape and gene-regulatory network of human gastric corpus epithelium	46
Gene print-based cell subtypes annotation of human disease across heterogeneous datasets with gPRINT	42
Gut microbial methionine impacts circadian clock gene expression and reactive oxygen species level in host gastrointestinal tract	38
Withdrawn as Duplicate: Remembering the Scholar Ding Ying: The Father of Chinese Rice-Farming Science	37
Single-nucleus transcriptomics reveals a gatekeeper role for FOXP1 in primate cardiac aging	37
Unfolding HBx for an epigenetic switch of HBV cccDNA minichromosome	32
Strategies for generating mouse model resources of human disease	31
An ultrapotent pan-β-coronavirus lineage B (β-CoV-B) neutralizing antibody locks the receptor-binding domain in closed conformation by targeting its conserved epitope	31
Cryo-EM structures of Nipah virus polymerase complex reveal highly varied interactions between L and P proteins among paramyxoviruses	30
Dynamin 1-mediated endocytic recycling of glycosylated N-cadherin sustains the plastic mesenchymal state to promote ovarian cancer metastasis	30
Inheritance and advancement in biochemistry: the pioneering research of Szu-Chih Liu	28
Mutations in the SARS-CoV-2 spike receptor binding domain and their delicate balance between ACE2 affinity and antibody evasion	28
An orally-available monovalent SMAC mimetic compound as a broad-spectrum antiviral	27

Immune rebalancing at the maternal-fetal interface of maternal SARS-CoV-2 infection during early pregnancy	26
A hnRNPA2B1 agonist effectively inhibits HBV and SARS-CoV-2 omicronin vivo	24
A long non-coding RNA LncSync regulates mouse cardiomyocyte homeostasis and cardiac hypertrophy through coordination of miRNA actions	23
Pasteurized Akkermansia muciniphila promotes GP2 expression in microfold cells and facilitates Salmonella infection	23
Correction to: SIRT7 antagonizes human stem cell aging as a heterochromatin stabilizer	22
A tribute to Professor Yong Zhao	22
Correction to: Genome-wide CRISPR screen identifies synthetic lethality between DOCK1 inhibition and metformin in liver cancer	22
Long-term in vivo chimeric cells tracking in non-human primate	21
Oxidative phosphorylation safeguards pluripotency via UDP-N-acetylglucosamine	20
High-throughput screening of SARS-CoV-2 main and papain-like protease inhibitors	20
Adenosine-to-inosine RNA editing in cancer: molecular mechanisms and downstream targets	19
Radiation injury and gut microbiota-based treatment	17
Advances in gene and cellular therapeutic approaches for Huntington’s disease	17
Hunting out the repeat expansion in Huntington’s pigs	16
Modeling hepatoblastoma development with human fetal liver organoids reveals YAP1 activation is sufficient for tumorigenesis	16
Microbial sensing in the intestine	16
SMURF1: a promising target for colon cancer therapy	16
Proteomic analysis of ferroptosis pathways reveals a role of CEPT1 in suppressing ferroptosis	16
Endosomal catabolism of phosphatidylinositol 4,5-bisphosphate is fundamental in building resilience against pathogens	15
Correction to: Adenosine-to-inosine RNA editing in cancer: molecular mechanisms and downstream targets	15
Single transmembrane GPCR modulating proteins: neither single nor simple	15
Systematicidentification of CRISPR off-target effects by CROss-seq	14
Glutamine signaling specifically activates c-Myc and Mcl-1 to Facilitate cancer cell proliferation and survival	14
Secreted proteins in treating metabolic dysfunction-associated steatotic liver disease: from bench towards bedside	14
The microbiota–gut–brain axis and neurodevelopmental disorders	13
Aberrant outputs of cerebellar nuclei and targeted rescue of social deficits in an autism mouse model	12
Synergistic innovation in organ-on-a-chip and organoid technologies: Reshaping the future of disease modeling, drug development and precision medicine	12
Correction to: The nucleocapsid protein of rice stripe virus in cell nuclei of vector insect regulates viral replication	12
Single-cell profiling reveals a potent role of quercetin in promoting hair regeneration	12
Boundless love: a German Professor Uli Schwarz in China	12
Structural studies promote vaccine development: lessons from African swine fever virus	11
Syn3, a newly developed cyclic peptide and BDNF signaling enhancer, ameliorates retinal ganglion cell degeneration in diabetic retinopathy	11
Single-nucleus transcriptomics uncovers a geroprotective role of YAP in primate gingival aging	11
Degeneration Directory: a multi-omics web resource for degenerative diseases	11
Sung Shu Chien: The founder of modern Chinese botany	11
Systematic characterization of full-length RNA isoforms in human colorectal cancer at single-cell resolution	11
Tanjun Tong: a pioneer of cellular senescence and aging mechanism research in China	11
Join the club: ORP8 is a lipophagy receptor	10
The chordata olfactory receptor database	10
Virological research history in China: a century of profiling virologists’ contributions and virological innovations	10
Governing glutaminolysis by regulation of glutaminase succinylation	10
Epigenetic integrity of paternal imprints enhances the developmental potential of androgenetic haploid embryonic stem cells	10
PINK1 kinase dysfunction triggers neurodegeneration in the primate brain without impacting mitochondrial homeostasis	10
Human ESC-derived vascular cells promote vascular regeneration in a HIF-1α dependent manner	9
Single-nucleus profiling unveils a geroprotective role of the FOXO3 in primate skeletal muscle aging	9
A molecular brake that modulates spliceosome pausing at detained introns contributes to neurodegeneration	9
mTORC2/RICTOR exerts differential levels of metabolic control in human embryonic, mesenchymal and neural stem cells	9
Gut dysbiosis impairs intestinal renewal and lipid absorption in Scarb2 deficiency-associated neurodegeneration	8
Platelet RNA signature independently predicts ovarian cancer prognosis by deep learning neural network model	8
RNA helicase MTR4 drives tumorigenesis of nasopharyngeal carcinoma by regulating the expression of key cell cycle genes	8

Bardoxolone methyl blocks the efflux of Zn2+ by targeting hZnT1 to inhibit the proliferation and metastasis of cervical cancer	8
Structural basis of INTAC-regulated transcription	8
The role of parkin in monkey	8
Platelet RNA enables accurate detection of ovarian cancer: an intercontinental, biomarker identification study	8
Whole-exome sequencing identifies ECPAS as a novel potentially pathogenic gene in multiple hereditary families with nonsyndromic orofacial cleft	8
Cryo-EM structure of human κ-opioid receptor-Gi complex bound to an endogenous agonist dynorphin A	8
PDHX acetylation facilitates tumor progression by disrupting PDC assembly and activating lactylation-mediated gene expression	7
MultiKano: an automatic cell type annotation tool for single-cell multi-omics data based on Kolmogorov–Arnold network and data augmentation	7
Ergothioneine and its congeners: anti-ageing mechanisms and pharmacophore biosynthesis	7
Noncoding RNA Terc-53 and hyaluronan receptor Hmmr regulate aging in mice	7
Macrophages suppress cardiac reprogramming of fibroblasts in vivo via IFN-mediated intercellular self-stimulating circuit	6
The p15 protein is a promising immunogen for developing protective immunity against African swine fever virus	6
“Sentinel or accomplice”: gut microbiota and microglia crosstalk in disorders of gut–brain interaction	6
Setd2 overexpression rescues bivalent gene expression during SCNT-mediated ZGA	6
Precise genome editing without exogenous donor DNA via retron editing system in human cells	6
The chemical reprogramming of unipotent adult germ cells towards authentic pluripotency and de novo establishment of imprinting	6
Optimized derivation and culture system of human naïve pluripotent stem cells with enhanced DNA methylation status and genomic stability	6
A minimally invasive, fast on/off “odorgenetic” method to manipulate physiology	6
A novel loop-structure-based bispecific CAR that targets CD19 and CD22 with enhanced therapeutic efficacy against B-cell malignancies	6
An engineered xCas12i with high activity, high specificity and broad PAM range	6
BiFC and FACS-based CRISPR screening revealed that QKI promotes PABPN1 LLPS in colorectal cancer cells	6
Drug repurposing screening and mechanism analysis based on human colorectal cancer organoids	6
Single-dose AAV-based vaccine induces a high level of neutralizing antibodies against SARS-CoV-2 in rhesus macaques	5
Jiangsen Mao: a pioneer in Chinese hepatitis A vaccine and interferon research, a virologist at the forefront of times	5
Human 8-cell embryos enable efficient induction of disease-preventive mutations without off-target effect by cytosine base editor	5
Lamin C conserves DNA replication factors via phase separation during oxidative stress for DNA replication recovery	5
Structural basis for polyuridine tract recognition by SARS-CoV-2 Nsp15	5
Crystal structure of SARS-CoV-2 main protease in complex with protease inhibitor PF-07321332	5
CRL3 E3 ligase regulates glutamine and cystine metabolisms	5
Dual role of lipids for genome stability and pluripotency facilitates full potency of mouse embryonic stem cells	5
METTL14 is a chromatin regulator independent of its RNA N 6-methyladenosine methyltransferase activity	5
YME1L overexpression exerts pro-tumorigenic activity in glioma by promoting Gαi1 expression and Akt activation	5
Stress granules and organelles: coordinating cellular responses in health and disease	5
IL-24 promotes atopic dermatitis-like inflammation through driving MRSA-induced allergic responses	5
Persisting lung pathogenesis and minimum residual virus in hamster after acute COVID-19	5
Metabolic cell death in cancer: ferroptosis, cuproptosis, disulfidptosis, and beyond	5
EZH2 in non-cancerous diseases: expanding horizons	4
CARM1 drives triple-negative breast cancer progression by coordinating with HIF1A	4
Correction to: Metformin activates chaperone-mediated autophagy and improves disease pathologies in an Alzheimer disease mouse model	4
Skin organoid transplantation promotes tissue repair with scarless in frostbite	4
Correction to: Potentiating CD8+ T cell antitumor activity by inhibiting PCSK9 to promote LDLR-mediated TCR recycling and signaling	4
A promising clinical technique to rescue women’s ovarian aging: engineered stem cell-based therapy with the help of AI	4
Endothelial-to-Osteoblast Conversion maintains bone homeostasis through Kindlin-2/Piezo1/TGFβ/Runx2 axis	4
Two antibodies show broad, synergistic neutralization against SARS-CoV-2 variants by inducing conformational change within the RBD	4
APOE-mediated suppression of the lncRNA MEG3 protects human cardiovascular cells from chronic inflammation	4
Correction to: EGFR signaling augments TLR4 cell surface expression and function in macrophages via regulation of Rab5a activation	4
Face off: a metabolic enzyme becomes a protein phosphatase	4
Correction to: Engineered extracellular vesicles enable high-efficient delivery of intracellular therapeutic proteins	4
p21/Zbtb18 repress the expression of cKit to regulate the self-renewal of hematopoietic stem cells	4
Single-cell transcriptomic Atlas of mouse cochlear aging	4
Dietary pyruvate targets cytosolic phospholipase A2 to mitigate inflammation and obesity in mice	4
Phosphorylation of NF2 at Serine-13 by MAP4K family kinases mediates pathological angiogenesis	4
Molecular architecture of mammalian pyruvate dehydrogenase complex	4
Antiviral activity of lipoxygenase against severe fever with thrombocytopenia syndrome virus	3
RADICAL: a rationally designed ion channel activated by ligand for chemogenetics	3
SARS-CoV-2 ORF8 does not function in the nucleus as a histone mimic	3
A CRISPR activation screen identifies genes that enhance SARS-CoV-2 infection	3
Discovery of CCDC188 gene as a novel genetic target for human acephalic spermatozoa syndrome	3
Emerging roles of RNA N4-acetylcytidine modification in reproductive health	3
Correction to: ALKBH1 deficiency leads to loss of homeostasis in human diploid somatic cells	3
Comprehensive transcriptional atlas of human adenomyosis deciphered by the integration of single-cell RNA-sequencing and spatial transcriptomics	3
ORP8 acts as a lipophagy receptor to mediate lipid droplet turnover	3
Restoration of FMRP expression in adult V1 neurons rescues visual deficits in a mouse model of fragile X syndrome	3
Correction to: A world renowned psychophysiologist: Kaoliang Chow	3
cGAS guards against chromosome end-to-end fusions during mitosis and facilitates replicative senescence	3
Investigating regional-specific gut microbial distribution: an uncharted territory in disease therapeutics	3
The ubiquitin codes in cellular stress responses	3
NDFIP1 limits cellular TAZ accumulation via exosomal sorting to inhibit NSCLC proliferation	3