Protein & Cell

Article	Citations
“Always learn today, stand ready to act tomorrow”—Po Tien: A pioneer of Virology in China	167
Pan Shuh: the founding figure of modern Chinese psychology	164
Anthrax lethal toxin and tumor necrosis factor-α synergize on intestinal epithelia to induce mouse death	77
Spatially-resolved expression landscape and gene-regulatory network of human gastric corpus epithelium	74
Gut microbial methionine impacts circadian clock gene expression and reactive oxygen species level in host gastrointestinal tract	72
Withdrawn as Duplicate: Remembering the Scholar Ding Ying: The Father of Chinese Rice-Farming Science	67
Unfolding HBx for an epigenetic switch of HBV cccDNA minichromosome	62
DCK confers sensitivity of DCTD-positive cancer cells to oxidized methylcytidines	61
One step, two functions: the mechanism of the ABCH class of transporter serving barrier construction and detoxification in insects	51
Single-nucleus transcriptomics reveals a gatekeeper role for FOXP1 in primate cardiac aging	47
ARID1A IDR targets EWS-FLI1 condensates and finetunes chromatin remodeling	46
JMJD1C forms condensate to facilitate a RUNX1-dependent gene expression program shared by multiple types of AML cells	41
An improved method for the detection of double-stranded RNA suitable for quality control of mRNA vaccines	35
Endoplasmic reticulum membrane remodeling by targeting reticulon-4 induces pyroptosis to facilitate antitumor immune	34
Microbiome research outlook: past, present, and future	32
Architecture of severe fever with thrombocytopenia syndrome virus	31
Gene print-based cell subtypes annotation of human disease across heterogeneous datasets with gPRINT	31
Dynamin 1-mediated endocytic recycling of glycosylated N-cadherin sustains the plastic mesenchymal state to promote ovarian cancer metastasis	30
Cryo-EM structures of Nipah virus polymerase complex reveal highly varied interactions between L and P proteins among paramyxoviruses	30
Strategies for generating mouse model resources of human disease	27
An ultrapotent pan-β-coronavirus lineage B (β-CoV-B) neutralizing antibody locks the receptor-binding domain in closed conformation by targeting its conserved epitope	25
Efficient CRISPR-based gene activation using combinatorial human transcription activation domains	24
Inheritance and advancement in biochemistry: the pioneering research of Szu-Chih Liu	24
Mutations in the SARS-CoV-2 spike receptor binding domain and their delicate balance between ACE2 affinity and antibody evasion	23
A long non-coding RNA LncSync regulates mouse cardiomyocyte homeostasis and cardiac hypertrophy through coordination of miRNA actions	22

A hnRNPA2B1 agonist effectively inhibits HBV and SARS-CoV-2 omicronin vivo	22
Correction to: Genome-wide CRISPR screen identifies synthetic lethality between DOCK1 inhibition and metformin in liver cancer	22
Immune rebalancing at the maternal-fetal interface of maternal SARS-CoV-2 infection during early pregnancy	21
An orally-available monovalent SMAC mimetic compound as a broad-spectrum antiviral	20
Pasteurized Akkermansia muciniphila promotes GP2 expression in microfold cells and facilitates Salmonella infection	20
Correction to: SIRT7 antagonizes human stem cell aging as a heterochromatin stabilizer	18
A tribute to Professor Yong Zhao	18
High-throughput screening of SARS-CoV-2 main and papain-like protease inhibitors	17
Microbial sensing in the intestine	17
Oxidative phosphorylation safeguards pluripotency via UDP-N-acetylglucosamine	17
Long-term in vivo chimeric cells tracking in non-human primate	17
Proteomic analysis of ferroptosis pathways reveals a role of CEPT1 in suppressing ferroptosis	17
Advances in gene and cellular therapeutic approaches for Huntington’s disease	16
Adenosine-to-inosine RNA editing in cancer: molecular mechanisms and downstream targets	16
Accumulation of newly synthesized docosahexaenoic acid plays an essential role in heart regeneration	16
Hunting out the repeat expansion in Huntington’s pigs	15
Radiation injury and gut microbiota-based treatment	15
Glutamine signaling specifically activates c-Myc and Mcl-1 to facilitate cancer cell proliferation and survival	14
Secreted proteins in treating metabolic dysfunction-associated steatotic liver disease: from bench towards bedside	14
Endosomal catabolism of phosphatidylinositol 4,5-bisphosphate is fundamental in building resilience against pathogens	14
Modeling hepatoblastoma development with human fetal liver organoids reveals YAP1 activation is sufficient for tumorigenesis	14
SMURF1: a promising target for colon cancer therapy	14
The microbiota–gut–brain axis and neurodevelopmental disorders	13
Single transmembrane GPCR modulating proteins: neither single nor simple	13
Correction to: Adenosine-to-inosine RNA editing in cancer: molecular mechanisms and downstream targets	13
Systematicidentification of CRISPR off-target effects by CROss-seq	13
Boundless love: a German Professor Uli Schwarz in China	12
Systematic characterization of full-length RNA isoforms in human colorectal cancer at single-cell resolution	12
Tanjun Tong: a pioneer of cellular senescence and aging mechanism research in China	11
Synergistic innovation in organ-on-a-chip and organoid technologies: Reshaping the future of disease modeling, drug development and precision medicine	11
Sung Shu Chien: The founder of modern Chinese botany	11
Aberrant outputs of cerebellar nuclei and targeted rescue of social deficits in an autism mouse model	11
Single-cell profiling reveals a potent role of quercetin in promoting hair regeneration	11
Correction to: The nucleocapsid protein of rice stripe virus in cell nuclei of vector insect regulates viral replication	11
Correction to: Endothelial-to-Osteoblast Conversion maintains bone homeostasis through Kindlin-2/Piezo1/TGFβ/Runx2 axis	10
Syn3, a newly developed cyclic peptide and BDNF signaling enhancer, ameliorates retinal ganglion cell degeneration in diabetic retinopathy	10
Degeneration Directory: a multi-omics web resource for degenerative diseases	10
Single-nucleus transcriptomics uncovers a geroprotective role of YAP in primate gingival aging	10
Structural studies promote vaccine development: lessons from African swine fever virus	10
The chordata olfactory receptor database	9
Epigenetic integrity of paternal imprints enhances the developmental potential of androgenetic haploid embryonic stem cells	9
Virological research history in China: a century of profiling virologists’ contributions and virological innovations	9
A molecular brake that modulates spliceosome pausing at detained introns contributes to neurodegeneration	9
Join the club: ORP8 is a lipophagy receptor	9
mTORC2/RICTOR exerts differential levels of metabolic control in human embryonic, mesenchymal and neural stem cells	8
Platelet RNA enables accurate detection of ovarian cancer: an intercontinental, biomarker identification study	8
Human ESC-derived vascular cells promote vascular regeneration in a HIF-1α dependent manner	8
Governing glutaminolysis by regulation of glutaminase succinylation	8
PINK1 kinase dysfunction triggers neurodegeneration in the primate brain without impacting mitochondrial homeostasis	8
Cryo-EM structure of human κ-opioid receptor-Gi complex bound to an endogenous agonist dynorphin A	8

The role of parkin in monkey	7
Gut dysbiosis impairs intestinal renewal and lipid absorption in Scarb2 deficiency-associated neurodegeneration	7
Bardoxolone methyl blocks the efflux of Zn2+ by targeting hZnT1 to inhibit the proliferation and metastasis of cervical cancer	7
Structural basis of INTAC-regulated transcription	7
Whole-exome sequencing identifies ECPAS as a novel potentially pathogenic gene in multiple hereditary families with nonsyndromic orofacial cleft	7
Single-nucleus profiling unveils a geroprotective role of the FOXO3 in primate skeletal muscle aging	7
RNA helicase MTR4 drives tumorigenesis of nasopharyngeal carcinoma by regulating the expression of key cell cycle genes	7
A minimally invasive, fast on/off “odorgenetic” method to manipulate physiology	6
Ergothioneine and its congeners: anti-ageing mechanisms and pharmacophore biosynthesis	6
The p15 protein is a promising immunogen for developing protective immunity against African swine fever virus	6
A novel loop-structure-based bispecific CAR that targets CD19 and CD22 with enhanced therapeutic efficacy against B-cell malignancies	6
The chemical reprogramming of unipotent adult germ cells towards authentic pluripotency and de novo establishment of imprinting	6
Macrophages suppress cardiac reprogramming of fibroblasts in vivo via IFN-mediated intercellular self-stimulating circuit	6
Platelet RNA signature independently predicts ovarian cancer prognosis by deep learning neural network model	6
MultiKano: an automatic cell type annotation tool for single-cell multi-omics data based on Kolmogorov–Arnold network and data augmentation	6
Noncoding RNA Terc-53 and hyaluronan receptor Hmmr regulate aging in mice	6
An engineered xCas12i with high activity, high specificity and broad PAM range	6
BiFC and FACS-based CRISPR screening revealed that QKI promotes PABPN1 LLPS in colorectal cancer cells	6
PDHX acetylation facilitates tumor progression by disrupting PDC assembly and activating lactylation-mediated gene expression	6
Genome-wide investigation of transcription factor occupancy and dynamics using cFOOT-seq	6
Optimized derivation and culture system of human naïve pluripotent stem cells with enhanced DNA methylation status and genomic stability	6
Structural basis for polyuridine tract recognition by SARS-CoV-2 Nsp15	5
YME1L overexpression exerts pro-tumorigenic activity in glioma by promoting Gαi1 expression and Akt activation	5
Setd2 overexpression rescues bivalent gene expression during SCNT-mediated ZGA	5
Stress granules and organelles: coordinating cellular responses in health and disease	5
IL-24 promotes atopic dermatitis-like inflammation through driving MRSA-induced allergic responses	5
Drug repurposing screening and mechanism analysis based on human colorectal cancer organoids	5
Human 8-cell embryos enable efficient induction of disease-preventive mutations without off-target effect by cytosine base editor	5
Single-dose AAV-based vaccine induces a high level of neutralizing antibodies against SARS-CoV-2 in rhesus macaques	5
Jiangsen Mao: a pioneer in Chinese hepatitis A vaccine and interferon research, a virologist at the forefront of times	5
Persisting lung pathogenesis and minimum residual virus in hamster after acute COVID-19	5
“Sentinel or accomplice”: gut microbiota and microglia crosstalk in disorders of gut–brain interaction	5
Crystal structure of SARS-CoV-2 main protease in complex with protease inhibitor PF-07321332	5
Specific Pathogen Free Ten Gene-Edited Donor Pigs for Xenotransplantation	5
METTL14 is a chromatin regulator independent of its RNA N 6-methyladenosine methyltransferase activity	4
Two antibodies show broad, synergistic neutralization against SARS-CoV-2 variants by inducing conformational change within the RBD	4
Correction to: Metformin activates chaperone-mediated autophagy and improves disease pathologies in an Alzheimer disease mouse model	4
Dietary pyruvate targets cytosolic phospholipase A2 to mitigate inflammation and obesity in mice	4
Phosphorylation of NF2 at Serine-13 by MAP4K family kinases mediates pathological angiogenesis	4
Lamin C conserves DNA replication factors via phase separation during oxidative stress for DNA replication recovery	4
Metabolic cell death in cancer: ferroptosis, cuproptosis, disulfidptosis, and beyond	4
Single-cell transcriptomic Atlas of mouse cochlear aging	4
APOE-mediated suppression of the lncRNA MEG3 protects human cardiovascular cells from chronic inflammation	4
Correction to: EGFR signaling augments TLR4 cell surface expression and function in macrophages via regulation of Rab5a activation	4
Dual role of lipids for genome stability and pluripotency facilitates full potency of mouse embryonic stem cells	4
CARM1 drives triple-negative breast cancer progression by coordinating with HIF1A	4
CRL3 E3 ligase regulates glutamine and cystine metabolisms	4
Skin organoid transplantation promotes tissue repair with scarless in frostbite	4
p21/Zbtb18 repress the expression of cKit to regulate the self-renewal of hematopoietic stem cells	4
Emerging roles of RNA N4-acetylcytidine modification in reproductive health	3
Correction to: A world renowned psychophysiologist: Kaoliang Chow	3
NDFIP1 limits cellular TAZ accumulation via exosomal sorting to inhibit NSCLC proliferation	3
A promising clinical technique to rescue women’s ovarian aging: engineered stem cell-based therapy with the help of AI	3
Face off: a metabolic enzyme becomes a protein phosphatase	3
Correction to: ALKBH1 deficiency leads to loss of homeostasis in human diploid somatic cells	3
RADICAL: a rationally designed ion channel activated by ligand for chemogenetics	3
SARS-CoV-2 ORF8 does not function in the nucleus as a histone mimic	3
EZH2 in non-cancerous diseases: expanding horizons	3
Endothelial-to-Osteoblast Conversion maintains bone homeostasis through Kindlin-2/Piezo1/TGFβ/Runx2 axis	3
Antiviral activity of lipoxygenase against severe fever with thrombocytopenia syndrome virus	3
Investigating regional-specific gut microbial distribution: an uncharted territory in disease therapeutics	3
cGAS guards against chromosome end-to-end fusions during mitosis and facilitates replicative senescence	3
Discovery of CCDC188 gene as a novel genetic target for human acephalic spermatozoa syndrome	3
Correction to: Engineered extracellular vesicles enable high-efficient delivery of intracellular therapeutic proteins	3
Correction to: Potentiating CD8+ T cell antitumor activity by inhibiting PCSK9 to promote LDLR-mediated TCR recycling and signaling	3
Molecular architecture of mammalian pyruvate dehydrogenase complex	3
A CRISPR activation screen identifies genes that enhance SARS-CoV-2 infection	2
Restoration of FMRP expression in adult V1 neurons rescues visual deficits in a mouse model of fragile X syndrome	2
Targeting IRG1 in tumor-associated macrophages for cancer therapy	2
Professor Delong Su: a pioneer in Schistosomiasis Eradication in China	2
Lentivirus-modified hematopoietic stem cell gene therapy for advanced symptomatic juvenile metachromatic leukodystrophy: a long-term follow-up pilot study	2
RNA G-quadruplex (rG4) exacerbates cellular senescence by mediating ribosome pausing	2
ORP8 acts as a lipophagy receptor to mediate lipid droplet turnover	2
Asymmetric reconstruction of the aquareovirus core at near-atomic resolution and mechanism of transcription initiation	2
The ubiquitin codes in cellular stress responses	2
Structure, identification, and characterization of the RibD-enolase complex in Francisella	2
Follicle stimulating hormone controls granulosa cell glutamine synthesis to regulate ovulation	2
Zhu Xi: A Pioneer of Experimental Biology	2
Comprehensive transcriptional atlas of human adenomyosis deciphered by the integration of single-cell RNA-sequencing and spatial transcriptomics	2
Ko Kuei Chen: A Pioneer of Modern Pharmacological Research in China	2

Structure-based engineering of the midnolin-proteasome pathway for targeted protein degradation	2
In memory of the well-renowned Chinese cellular biologist Shien Sher-Pu	2
Correction to: DJ-1 is dispensable for human stem cell homeostasis	2