Protein & Cell

Article	Citations
Withdrawn as Duplicate: Remembering the Scholar Ding Ying: The Father of Chinese Rice-Farming Science	335
Gene print-based cell subtypes annotation of human disease across heterogeneous datasets with gPRINT	326
Pan Shuh: the founding figure of modern Chinese psychology	189
JMJD1C forms condensate to facilitate a RUNX1-dependent gene expression program shared by multiple types of AML cells	172
Spatially-resolved expression landscape and gene-regulatory network of human gastric corpus epithelium	131
DHA, a potentially therapeutic lipid for myocardial infarction	124
Unfolding HBx for an epigenetic switch of HBV cccDNA minichromosome	97
Anthrax lethal toxin and tumor necrosis factor-α synergize on intestinal epithelia to induce mouse death	81
ARID1A IDR targets EWS-FLI1 condensates and finetunes chromatin remodeling	76
An improved method for the detection of double-stranded RNA suitable for quality control of mRNA vaccines	74
Single-nucleus transcriptomics reveals a gatekeeper role for FOXP1 in primate cardiac aging	66
Recent progresses in cancer multidrug resistance and therapeutic options associated with protein damage response	66
Microbiome research outlook: past, present, and future	58
Topology-Driven Activation of the GLP-1 Receptor Promotes Adipose Tissue Browning	57
Correction to: Metformin inhibits pancreatic cancer metastasis caused by SMAD4 deficiency and consequent HNF4G upregulation	55
Architecture of severe fever with thrombocytopenia syndrome virus	54
Endoplasmic reticulum membrane remodeling by targeting reticulon-4 induces pyroptosis to facilitate antitumor immune	51
Astragalus membranaceus ameliorates endometrial aging and restores receptivity by enhancing mitochondrial function in stromal and epithelial cells	50
One step, two functions: the mechanism of the ABCH class of transporter serving barrier construction and detoxification in insects	41
Inheritance and advancement in biochemistry: the pioneering research of Szu-Chih Liu	40
Efficient clustered, regularly interspaced short palindromic repeats-based gene activation using combinatorial human transcription activation domains	39
Dynamin 1-mediated endocytic recycling of glycosylated N-cadherin sustains the plastic mesenchymal state to promote ovarian cancer metastasis	38
Strategies for generating mouse model resources of human disease	37
A single-cell transcriptomic landscape characterizes the endocrine system aging in the mouse	36
3D chromatin dynamics in cellular neuroendocrine transformation	35

NSUN2‑mediated epitranscriptomic and ubiquitin modulation of Nipah virus matrix protein reveals a dual-targeting antiviral strategy	34
Cryo-EM structures of Nipah virus polymerase complex reveal highly varied interactions between L and P proteins among paramyxoviruses	34
Shared CRISPR arrays underpin type I-A/I-B coexistence	33
Pasteurized Akkermansia muciniphila promotes GP2 expression in microfold cells and facilitates Salmonella infection	32
Mutations in the SARS-CoV-2 spike receptor binding domain and their delicate balance between ACE2 affinity and antibody evasion	32
Restoring the FOXO1 geroprotective pathway via seno-resistant mesenchymal progenitor cells alleviates primate epididymal aging	31
Correction to: Genome-wide CRISPR screen identifies synthetic lethality between DOCK1 inhibition and metformin in liver cancer	31
Immune rebalancing at the maternal-fetal interface of maternal SARS-CoV-2 infection during early pregnancy	30
An orally-available monovalent SMAC mimetic compound as a broad-spectrum antiviral	30
Tuning the Hsp70 chaperone cycle: emerging roles of GrpE-like nucleotide exchange factors in proteostasis and organelle function	29
Long-term in vivo chimeric cells tracking in non-human primate	29
Correction to: SIRT7 antagonizes human stem cell aging as a heterochromatin stabilizer	29
High-throughput screening of SARS-CoV-2 main and papain-like protease inhibitors	29
Primate abnormal spindle-like microcephaly-associated knockout causes severe microcephaly and oligodendrocyte loss in the brain	28
Oxidative phosphorylation safeguards pluripotency via UDP-N-acetylglucosamine	27
Tumor cell GPX4 dictates triacylglycerol metabolism for ferroptosis susceptibility and immune evasion of NSCLC	27
Accumulation of newly synthesized docosahexaenoic acid plays an essential role in heart regeneration	26
What we can learn from hibernators and other adapted animals about organ transplantation: mechanisms of cold resistance and enhanced regeneration	25
Advances in gene and cellular therapeutic approaches for Huntington’s disease	24
Adenosine-to-inosine RNA editing in cancer: molecular mechanisms and downstream targets	24
Microbial sensing in the intestine	23
Radiation injury and gut microbiota-based treatment	22
Proteomic analysis of ferroptosis pathways reveals a role of CEPT1 in suppressing ferroptosis	22
SMURF1: a promising target for colon cancer therapy	21
Endosomal catabolism of phosphatidylinositol 4,5-bisphosphate is fundamental in building resilience against pathogens	21
Single transmembrane GPCR modulating proteins: neither single nor simple	20
Secreted proteins in treating metabolic dysfunction-associated steatotic liver disease: from bench towards bedside	19
Correction to: Adenosine-to-inosine RNA editing in cancer: molecular mechanisms and downstream targets	19
Hunting out the repeat expansion in Huntington’s pigs	19
The microbiota–gut–brain axis and neurodevelopmental disorders	18
Glutamine signaling specifically activates c-Myc and Mcl-1 to facilitate cancer cell proliferation and survival	18
MANF is essential for astrocyte survival in the monkey brain	18
Systematic characterization of full-length RNA isoforms in human colorectal cancer at single-cell resolution	17
Aberrant outputs of cerebellar nuclei and targeted rescue of social deficits in an autism mouse model	17
Boundless love: a German Professor Uli Schwarz in China	17
Single-cell profiling reveals a potent role of quercetin in promoting hair regeneration	17
Oncogenic role of the SLC7A13-SLC3A1 cystine transporter in human luminal breast cancer and its cryo-EM structure	16
Correction to: DHA, a potentially therapeutic lipid for myocardial infarction	16
Synergistic innovation in organ-on-a-chip and organoid technologies: reshaping the future of disease modeling, drug development, and precision medicine	16
Degeneration Directory: a multi-omics web resource for degenerative diseases	15
Sung Shu Chien: The founder of modern Chinese botany	15
Syn3, a newly developed cyclic peptide and BDNF signaling enhancer, ameliorates retinal ganglion cell degeneration in diabetic retinopathy	14
Correction to: Endothelial-to-Osteoblast Conversion maintains bone homeostasis through Kindlin-2/Piezo1/TGFβ/Runx2 axis	14
Single-nucleus transcriptomics uncovers a geroprotective role of YAP in primate gingival aging	13
The chordata olfactory receptor database	13
Tanjun Tong: a pioneer of cellular senescence and aging mechanism research in China	13
Structural studies promote vaccine development: lessons from African swine fever virus	13
Virological research history in China: a century of profiling virologists’ contributions and virological innovations	13
Join the club: ORP8 is a lipophagy receptor	12
Human ESC-derived vascular cells promote vascular regeneration in a HIF-1α dependent manner	12

A molecular brake that modulates spliceosome pausing at detained introns contributes to neurodegeneration	11
Whole-exome sequencing identifies ECPAS as a novel potentially pathogenic gene in multiple hereditary families with nonsyndromic orofacial cleft	11
Cryo-EM structure of human κ-opioid receptor-Gi complex bound to an endogenous agonist dynorphin A	11
MMP-9 regulates disulphide isomerase activity of TGM2 to enhance fusion glycoprotein-mediated syncytium formation of respiratory syncytial virus	11
The role of parkin in monkey	11
RNA helicase MTR4 drives tumorigenesis of nasopharyngeal carcinoma by regulating the expression of key cell cycle genes	11
Platelet RNA enables accurate detection of ovarian cancer: an intercontinental, biomarker identification study	10
Platelet RNA signature independently predicts ovarian cancer prognosis by deep learning neural network model	10
Single-nucleus profiling unveils a geroprotective role of the FOXO3 in primate skeletal muscle aging	10
Ergothioneine and its congeners: anti-ageing mechanisms and pharmacophore biosynthesis	10
Bardoxolone methyl blocks the efflux of Zn2+ by targeting hZnT1 to inhibit the proliferation and metastasis of cervical cancer	10
A yolk sac-derived hepatic γδ T cell subpopulation develops in a hematopoietic stem cell- and thymus-independent manner	10
Kechun Lin: a pioneer of biophysics explorations in China	10
Structural basis of INTAC-regulated transcription	10
Gut dysbiosis impairs intestinal renewal and lipid absorption in Scarb2 deficiency-associated neurodegeneration	10
CRISPR screening identifies GNPTAB as a noncanonical STING activator driving cellular senescence	9
Noncoding RNA Terc-53 and hyaluronan receptor Hmmr regulate aging in mice	9
A novel loop-structure-based bispecific CAR that targets CD19 and CD22 with enhanced therapeutic efficacy against B-cell malignancies	9
An engineered xCas12i with high activity, high specificity and broad PAM range	9
Molecular basis of high-torque transmission of the Vibrio polar flagellar motor	9
Genome-wide investigation of transcription factor footprints and dynamics using cFOOT-seq	9
Advances in multi-omics for esophageal squamous cell carcinoma: diagnostic, prognostic, and therapeutic perspectives	9
BiFC and FACS-based CRISPR screening revealed that QKI promotes PABPN1 LLPS in colorectal cancer cells	9
“Sentinel or accomplice”: gut microbiota and microglia crosstalk in disorders of gut–brain interaction	9
The chemical reprogramming of unipotent adult germ cells towards authentic pluripotency and de novo establishment of imprinting	9
PDHX acetylation facilitates tumor progression by disrupting PDC assembly and activating lactylation-mediated gene expression	9
MultiKano: an automatic cell type annotation tool for single-cell multi-omics data based on Kolmogorov–Arnold network and data augmentation	9
Harnessing human tumor organoids for cancer modeling and precision therapy	8
Optimized derivation and culture system of human naïve pluripotent stem cells with enhanced DNA methylation status and genomic stability	8
Correction to: Skin organoid transplantation promotes tissue repair with scarless in frostbite	8
The p15 protein is a promising immunogen for developing protective immunity against African swine fever virus	8
Human meibomian gland organoids to study epithelial homeostasis and dysfunction	8
Drug repurposing screening and mechanism analysis based on human colorectal cancer organoids	8
The unexpected role of RagC in ketogenic diet-derived BHB sensing	8
A minimally invasive, fast on/off “odorgenetic” method to manipulate physiology	8
Macrophages suppress cardiac reprogramming of fibroblasts in vivo via IFN-mediated intercellular self-stimulating circuit	8
YME1L overexpression exerts pro-tumorigenic activity in glioma by promoting Gαi1 expression and Akt activation	8
Human 8-cell embryos enable efficient induction of disease-preventive mutations without off-target effect by cytosine base editor	7
Specific pathogen free ten gene-edited donor pigs for xenotransplantation	7
Patient‑specific profiling of TCR‑T cell efficacy enabled by a rapid and standardized reporter system	7
Tumor cell intrinsic dsRNA innate immune response triggered by PARP inhibitor is compromised in BRCA1-deficient breast cancer by repressing IRF3	7
CTCF’s loop-independent functions prevail over chromatin looping in the acute degradation system	7
Structural and mechanistic insights into symmetry conversion in plant GORK K+ channel regulation	7
Structural basis for the synaptic adhesion protein ELFN1-mediated modulation of mGlu7	6
O-GlcNAc clusters in intrinsically disordered regions regulate transcriptional condensates and gene control	6
Setd2 overexpression rescues bivalent gene expression during SCNT-mediated ZGA	6
Jiangsen Mao: a pioneer in Chinese hepatitis A vaccine and interferon research, a virologist at the forefront of times	6
Human embryo editing: 10 years of breakthroughs and challenges	6
Stress granules and organelles: coordinating cellular responses in health and disease	6
Phase separation of DUX family proteins drives totipotent-like state via 3D genome reorganization and retrotransposon activation	6
Molecular insights into Candida auris glycosylphosphatidylinositol transamidase	5
IL-24 promotes atopic dermatitis-like inflammation through driving MRSA-induced allergic responses	5
Lamin C conserves DNA replication factors via phase separation during oxidative stress for DNA replication recovery	5
CRL3 E3 ligase regulates glutamine and cystine metabolisms	5
Dual role of lipids for genome stability and pluripotency facilitates full potency of mouse embryonic stem cells	5
Lipid-gated “phosphorylation code” for TCR graded signaling and T-cell exhaustion	5
METTL14 is a chromatin regulator independent of its RNA N 6-methyladenosine methyltransferase activity	5
Structural basis for polyuridine tract recognition by SARS-CoV-2 Nsp15	4
Two antibodies show broad, synergistic neutralization against SARS-CoV-2 variants by inducing conformational change within the RBD	4
Skin organoid transplantation promotes tissue repair with scarless in frostbite	4
Dietary pyruvate targets cytosolic phospholipase A2 to mitigate inflammation and obesity in mice	4
Correction to: Engineered extracellular vesicles enable high-efficient delivery of intracellular therapeutic proteins	4
GA-binding protein alpha ensures proper blastocyst development by suppressing SMAD3-mediated transforming growth factor-beta signaling	4
Metabolic cell death in cancer: ferroptosis, cuproptosis, disulfidptosis, and beyond	4
DNA-triggered AIM2 condensation orchestrates immune activation and regulation	4
APOE-mediated suppression of the lncRNA MEG3 protects human cardiovascular cells from chronic inflammation	4
Lipid droplets, an enigmatic organelle under the spotlight	4
Face off: a metabolic enzyme becomes a protein phosphatase	4
MAAD: multidimensional antiviral antibody database	4
CARM1 drives triple-negative breast cancer progression by coordinating with HIF1A	4
Single-cell transcriptomic Atlas of mouse cochlear aging	4
Correction to: EGFR signaling augments TLR4 cell surface expression and function in macrophages via regulation of Rab5a activation	4
Phosphorylation of NF2 at Serine-13 by MAP4K family kinases mediates pathological angiogenesis	4
mRNA-LNP delivery of individual longevity genes mitigates doxorubicin-induced progeroid phenotypes	4
A promising clinical technique to rescue women’s ovarian aging: engineered stem cell-based therapy with the help of AI	4
Systematic analyses uncover plasma proteins linked to incident cardiovascular diseases	4
p21/Zbtb18 repress the expression of cKit to regulate the self-renewal of hematopoietic stem cells	4
Endosomes as central hubs of interorganellar communication and cellular homeostasis	3
EZH2 in non-cancerous diseases: expanding horizons	3
Antiviral activity of lipoxygenase against severe fever with thrombocytopenia syndrome virus	3

A programmable platform enabling targeted chromosome substitution and cross-species stability profiling	3
A CRISPR activation screen identifies genes that enhance SARS-CoV-2 infection	3
RADICAL: a rationally designed ion channel activated by ligand for chemogenetics	3
Chaf1a is required for cardiomyocyte karyokinesis and cardiac endowment	3
Pleural cavity macrophages promote lung tumor establishment through tissue invasion	3
Molecular architecture of mammalian pyruvate dehydrogenase complex	3
Correction to: ALKBH1 deficiency leads to loss of homeostasis in human diploid somatic cells	3
Investigating regional-specific gut microbial distribution: an uncharted territory in disease therapeutics	3
NDFIP1 limits cellular TAZ accumulation via exosomal sorting to inhibit NSCLC proliferation	3
Endothelial-to-Osteoblast Conversion maintains bone homeostasis through Kindlin-2/Piezo1/TGFβ/Runx2 axis	3
Structural basis of Arpin homodimerization reveals cooperative inhibition of the Arp2/3 complex through dual-site engagement	3
Engineering oncolytic bacteria as precision cancer therapeutics: design principles, therapeutic strategies, and translational perspectives	3
Emerging roles of RNA N4-acetylcytidine modification in reproductive health	3
SARS-CoV-2 ORF8 does not function in the nucleus as a histone mimic	3
Discovery of CCDC188 gene as a novel genetic target for human acephalic spermatozoa syndrome	3
RNA G-quadruplex (rG4) exacerbates cellular senescence by mediating ribosome pausing	2
Mechanism and design of allosteric activators of SIRT1	2
Asymmetric reconstruction of the aquareovirus core at near-atomic resolution and mechanism of transcription initiation	2
Zhu Xi: A Pioneer of Experimental Biology	2
rhMG53 induces pharmacological preconditioning by acting as an agonistic ligand of c-Met	2
Correction to: DJ-1 is dispensable for human stem cell homeostasis	2
AbCVista: a deep learning framework for predicting antibody conformational ensembles	2
Glutamine synthetase sustains cortical circuit development via mTOR-mediated astrocyte maturation	2
Deciphering the placental abnormalities associated with somatic cell nuclear transfer at single-nucleus resolution	2
Epigenetic Dynamics of Human Spermatogenesis and Their Dysregulation in Non-Obstructive Azoospermia	2
Follicle stimulating hormone controls granulosa cell glutamine synthesis to regulate ovulation	2
Targeting IRG1 in tumor-associated macrophages for cancer therapy	2
Ko Kuei Chen: A Pioneer of Modern Pharmacological Research in China	2
Comprehensive transcriptional atlas of human adenomyosis deciphered by the integration of single-cell RNA-sequencing and spatial transcriptomics	2
The ubiquitin codes in cellular stress responses	2
Mechanistic insights into the GEF activity of the human MON1A/CCZ1/C18orf8 complex	2
Structure, identification, and characterization of the RibD-enolase complex in Francisella	2
Lentivirus-modified hematopoietic stem cell gene therapy for advanced symptomatic juvenile metachromatic leukodystrophy: a long-term follow-up pilot study	2
GlycoRNA research: from unknown unknowns to known unknowns	2
Professor Delong Su: a pioneer in Schistosomiasis Eradication in China	2
Structure-based engineering of the midnolin-proteasome pathway for targeted protein degradation	2
ORP8 acts as a lipophagy receptor to mediate lipid droplet turnover	2
Spatiotemporal Ca2+ nanodomain remodeling at MERCS regulates mitochondrial proteostasis	2
Centered on child health: Zhu Futang and the foundations of pediatrics and measles prevention in China	2
Structural basis of allosteric and bitopic ligands binding in sphingosine-1-phosphate receptors 2 and 3	2
Periosteal reaction: a natural extracellular matrix barrier to prevent cancer-bone invasion	2