Protein & Cell

Article	Citations
Withdrawn as Duplicate: Remembering the Scholar Ding Ying: The Father of Chinese Rice-Farming Science	204
Gene print-based cell subtypes annotation of human disease across heterogeneous datasets with gPRINT	99
Pan Shuh: the founding figure of modern Chinese psychology	96
Unfolding HBx for an epigenetic switch of HBV cccDNA minichromosome	91
Single-nucleus transcriptomics reveals a gatekeeper role for FOXP1 in primate cardiac aging	84
JMJD1C forms condensate to facilitate a RUNX1-dependent gene expression program shared by multiple types of AML cells	74
An improved method for the detection of double-stranded RNA suitable for quality control of mRNA vaccines	53
DCK confers sensitivity of DCTD-positive cancer cells to oxidized methylcytidines	51
Spatially-resolved expression landscape and gene-regulatory network of human gastric corpus epithelium	49
Anthrax lethal toxin and tumor necrosis factor-α synergize on intestinal epithelia to induce mouse death	46
Endoplasmic reticulum membrane remodeling by targeting reticulon-4 induces pyroptosis to facilitate antitumor immune	41
Gut microbial methionine impacts circadian clock gene expression and reactive oxygen species level in host gastrointestinal tract	40
ARID1A IDR targets EWS-FLI1 condensates and finetunes chromatin remodeling	37
Architecture of severe fever with thrombocytopenia syndrome virus	37
DHA, a potentially therapeutic lipid for myocardial infarction	36
Microbiome research outlook: past, present, and future	33
One step, two functions: the mechanism of the ABCH class of transporter serving barrier construction and detoxification in insects	33
Inheritance and advancement in biochemistry: the pioneering research of Szu-Chih Liu	29
Dynamin 1-mediated endocytic recycling of glycosylated N-cadherin sustains the plastic mesenchymal state to promote ovarian cancer metastasis	28
Efficient CRISPR-based gene activation using combinatorial human transcription activation domains	27
Strategies for generating mouse model resources of human disease	26
3D chromatin dynamics in cellular neuroendocrine transformation	25
Cryo-EM structures of Nipah virus polymerase complex reveal highly varied interactions between L and P proteins among paramyxoviruses	24
A single-cell transcriptomic landscape characterizes the endocrine system aging in the mouse	23
Mutations in the SARS-CoV-2 spike receptor binding domain and their delicate balance between ACE2 affinity and antibody evasion	22

Correction to: Genome-wide CRISPR screen identifies synthetic lethality between DOCK1 inhibition and metformin in liver cancer	22
A long non-coding RNA LncSync regulates mouse cardiomyocyte homeostasis and cardiac hypertrophy through coordination of miRNA actions	22
Pasteurized Akkermansia muciniphila promotes GP2 expression in microfold cells and facilitates Salmonella infection	20
A hnRNPA2B1 agonist effectively inhibits HBV and SARS-CoV-2 omicronin vivo	20
Immune rebalancing at the maternal-fetal interface of maternal SARS-CoV-2 infection during early pregnancy	20
An orally-available monovalent SMAC mimetic compound as a broad-spectrum antiviral	20
Correction to: SIRT7 antagonizes human stem cell aging as a heterochromatin stabilizer	19
High-throughput screening of SARS-CoV-2 main and papain-like protease inhibitors	18
Proteomic analysis of ferroptosis pathways reveals a role of CEPT1 in suppressing ferroptosis	18
Long-term in vivo chimeric cells tracking in non-human primate	18
Tuning the Hsp70 chaperone cycle: emerging roles of GrpE-like NEFs in proteostasis and organelle function	18
Oxidative phosphorylation safeguards pluripotency via UDP-N-acetylglucosamine	18
Advances in gene and cellular therapeutic approaches for Huntington’s disease	18
Radiation injury and gut microbiota-based treatment	17
Accumulation of newly synthesized docosahexaenoic acid plays an essential role in heart regeneration	17
Microbial sensing in the intestine	16
Adenosine-to-inosine RNA editing in cancer: molecular mechanisms and downstream targets	16
Hunting out the repeat expansion in Huntington’s pigs	16
Secreted proteins in treating metabolic dysfunction-associated steatotic liver disease: from bench towards bedside	15
SMURF1: a promising target for colon cancer therapy	15
Correction to: Adenosine-to-inosine RNA editing in cancer: molecular mechanisms and downstream targets	14
Modeling hepatoblastoma development with human fetal liver organoids reveals YAP1 activation is sufficient for tumorigenesis	14
Systematicidentification of CRISPR off-target effects by CROss-seq	14
Endosomal catabolism of phosphatidylinositol 4,5-bisphosphate is fundamental in building resilience against pathogens	14
Glutamine signaling specifically activates c-Myc and Mcl-1 to facilitate cancer cell proliferation and survival	13
Single transmembrane GPCR modulating proteins: neither single nor simple	13
The microbiota–gut–brain axis and neurodevelopmental disorders	12
Oncogenic role of the SLC7A13-SLC3A1 cystine transporter in human luminal breast cancer and its cryo-EM structure	12
Boundless love: a German Professor Uli Schwarz in China	12
Synergistic innovation in organ-on-a-chip and organoid technologies: reshaping the future of disease modeling, drug development, and precision medicine	12
Systematic characterization of full-length RNA isoforms in human colorectal cancer at single-cell resolution	11
Single-cell profiling reveals a potent role of quercetin in promoting hair regeneration	11
Degeneration Directory: a multi-omics web resource for degenerative diseases	10
Syn3, a newly developed cyclic peptide and BDNF signaling enhancer, ameliorates retinal ganglion cell degeneration in diabetic retinopathy	10
Single-nucleus transcriptomics uncovers a geroprotective role of YAP in primate gingival aging	10
Tanjun Tong: a pioneer of cellular senescence and aging mechanism research in China	10
Correction to: Endothelial-to-Osteoblast Conversion maintains bone homeostasis through Kindlin-2/Piezo1/TGFβ/Runx2 axis	10
Structural studies promote vaccine development: lessons from African swine fever virus	10
Sung Shu Chien: The founder of modern Chinese botany	10
Aberrant outputs of cerebellar nuclei and targeted rescue of social deficits in an autism mouse model	10
Virological research history in China: a century of profiling virologists’ contributions and virological innovations	9
Governing glutaminolysis by regulation of glutaminase succinylation	9
Epigenetic integrity of paternal imprints enhances the developmental potential of androgenetic haploid embryonic stem cells	9
The chordata olfactory receptor database	8
PINK1 kinase dysfunction triggers neurodegeneration in the primate brain without impacting mitochondrial homeostasis	8
mTORC2/RICTOR exerts differential levels of metabolic control in human embryonic, mesenchymal and neural stem cells	8
Human ESC-derived vascular cells promote vascular regeneration in a HIF-1α dependent manner	8
Cryo-EM structure of human κ-opioid receptor-Gi complex bound to an endogenous agonist dynorphin A	8
Join the club: ORP8 is a lipophagy receptor	8
Bardoxolone methyl blocks the efflux of Zn2+ by targeting hZnT1 to inhibit the proliferation and metastasis of cervical cancer	8

A molecular brake that modulates spliceosome pausing at detained introns contributes to neurodegeneration	8
The role of parkin in monkey	7
Whole-exome sequencing identifies ECPAS as a novel potentially pathogenic gene in multiple hereditary families with nonsyndromic orofacial cleft	7
Platelet RNA enables accurate detection of ovarian cancer: an intercontinental, biomarker identification study	7
Structural basis of INTAC-regulated transcription	7
Single-nucleus profiling unveils a geroprotective role of the FOXO3 in primate skeletal muscle aging	7
RNA helicase MTR4 drives tumorigenesis of nasopharyngeal carcinoma by regulating the expression of key cell cycle genes	7
Platelet RNA signature independently predicts ovarian cancer prognosis by deep learning neural network model	7
Ergothioneine and its congeners: anti-ageing mechanisms and pharmacophore biosynthesis	7
Structural and mechanistic insights into symmetry conversion in plant GORK K+ channel regulation	6
Genome-wide investigation of transcription factor occupancy and dynamics using cFOOT-seq	6
The chemical reprogramming of unipotent adult germ cells towards authentic pluripotency and de novo establishment of imprinting	6
A minimally invasive, fast on/off “odorgenetic” method to manipulate physiology	6
Macrophages suppress cardiac reprogramming of fibroblasts in vivo via IFN-mediated intercellular self-stimulating circuit	6
“Sentinel or accomplice”: gut microbiota and microglia crosstalk in disorders of gut–brain interaction	6
MultiKano: an automatic cell type annotation tool for single-cell multi-omics data based on Kolmogorov–Arnold network and data augmentation	6
PDHX acetylation facilitates tumor progression by disrupting PDC assembly and activating lactylation-mediated gene expression	6
A novel loop-structure-based bispecific CAR that targets CD19 and CD22 with enhanced therapeutic efficacy against B-cell malignancies	6
Noncoding RNA Terc-53 and hyaluronan receptor Hmmr regulate aging in mice	6
The p15 protein is a promising immunogen for developing protective immunity against African swine fever virus	6
BiFC and FACS-based CRISPR screening revealed that QKI promotes PABPN1 LLPS in colorectal cancer cells	6
Gut dysbiosis impairs intestinal renewal and lipid absorption in Scarb2 deficiency-associated neurodegeneration	6
An engineered xCas12i with high activity, high specificity and broad PAM range	6
Drug repurposing screening and mechanism analysis based on human colorectal cancer organoids	6
Optimized derivation and culture system of human naïve pluripotent stem cells with enhanced DNA methylation status and genomic stability	6
Human 8-cell embryos enable efficient induction of disease-preventive mutations without off-target effect by cytosine base editor	5
Setd2 overexpression rescues bivalent gene expression during SCNT-mediated ZGA	5
METTL14 is a chromatin regulator independent of its RNA N 6-methyladenosine methyltransferase activity	5
IL-24 promotes atopic dermatitis-like inflammation through driving MRSA-induced allergic responses	5
CRL3 E3 ligase regulates glutamine and cystine metabolisms	5
Jiangsen Mao: a pioneer in Chinese hepatitis A vaccine and interferon research, a virologist at the forefront of times	5
YME1L overexpression exerts pro-tumorigenic activity in glioma by promoting Gαi1 expression and Akt activation	5
Stress granules and organelles: coordinating cellular responses in health and disease	5
Dual role of lipids for genome stability and pluripotency facilitates full potency of mouse embryonic stem cells	5
Metabolic cell death in cancer: ferroptosis, cuproptosis, disulfidptosis, and beyond	5
Single-dose AAV-based vaccine induces a high level of neutralizing antibodies against SARS-CoV-2 in rhesus macaques	5
Specific Pathogen Free Ten Gene-Edited Donor Pigs for Xenotransplantation	5
Lamin C conserves DNA replication factors via phase separation during oxidative stress for DNA replication recovery	5
Structural basis for polyuridine tract recognition by SARS-CoV-2 Nsp15	5
Two antibodies show broad, synergistic neutralization against SARS-CoV-2 variants by inducing conformational change within the RBD	5
Phosphorylation of NF2 at Serine-13 by MAP4K family kinases mediates pathological angiogenesis	4
p21/Zbtb18 repress the expression of cKit to regulate the self-renewal of hematopoietic stem cells	4
Correction to: EGFR signaling augments TLR4 cell surface expression and function in macrophages via regulation of Rab5a activation	4
APOE-mediated suppression of the lncRNA MEG3 protects human cardiovascular cells from chronic inflammation	4
Endothelial-to-Osteoblast Conversion maintains bone homeostasis through Kindlin-2/Piezo1/TGFβ/Runx2 axis	4
Single-cell transcriptomic Atlas of mouse cochlear aging	4
Systematic analyses uncover plasma proteins linked to incident cardiovascular diseases	4
Correction to: Metformin activates chaperone-mediated autophagy and improves disease pathologies in an Alzheimer disease mouse model	4
Skin organoid transplantation promotes tissue repair with scarless in frostbite	4
Correction to: Engineered extracellular vesicles enable high-efficient delivery of intracellular therapeutic proteins	4
GABPA ensures proper blastocyst development by suppressing SMAD3-mediated TGF-β signaling	4
CARM1 drives triple-negative breast cancer progression by coordinating with HIF1A	4
EZH2 in non-cancerous diseases: expanding horizons	4
Face off: a metabolic enzyme becomes a protein phosphatase	4
Dietary pyruvate targets cytosolic phospholipase A2 to mitigate inflammation and obesity in mice	4
Molecular architecture of mammalian pyruvate dehydrogenase complex	3
Antiviral activity of lipoxygenase against severe fever with thrombocytopenia syndrome virus	3
Correction to: ALKBH1 deficiency leads to loss of homeostasis in human diploid somatic cells	3
A promising clinical technique to rescue women’s ovarian aging: engineered stem cell-based therapy with the help of AI	3
Investigating regional-specific gut microbial distribution: an uncharted territory in disease therapeutics	3
Correction to: A world renowned psychophysiologist: Kaoliang Chow	3
Engineering oncolytic bacteria as precision cancer therapeutics: design principles, therapeutic strategies, and translational perspectives	3
Pleural cavity macrophages promote lung tumor establishment through tissue invasion	3
RADICAL: a rationally designed ion channel activated by ligand for chemogenetics	3
Emerging roles of RNA N4-acetylcytidine modification in reproductive health	3
Lentivirus-modified hematopoietic stem cell gene therapy for advanced symptomatic juvenile metachromatic leukodystrophy: a long-term follow-up pilot study	2
Periosteal reaction: a natural extracellular matrix barrier to prevent cancer-bone invasion	2
Zhu Xi: A Pioneer of Experimental Biology	2
ORP8 acts as a lipophagy receptor to mediate lipid droplet turnover	2
NDFIP1 limits cellular TAZ accumulation via exosomal sorting to inhibit NSCLC proliferation	2
Structure-based engineering of the midnolin-proteasome pathway for targeted protein degradation	2
Correction to: DJ-1 is dispensable for human stem cell homeostasis	2
Structure, identification, and characterization of the RibD-enolase complex in Francisella	2
Structural basis of allosteric and bitopic ligands binding in sphingosine-1-phosphate receptors 2 and 3	2
Mechanism and design of allosteric activators of SIRT1	2
Asymmetric reconstruction of the aquareovirus core at near-atomic resolution and mechanism of transcription initiation	2
The ubiquitin codes in cellular stress responses	2
SARS-CoV-2 ORF8 does not function in the nucleus as a histone mimic	2
Targeting IRG1 in tumor-associated macrophages for cancer therapy	2
Ko Kuei Chen: A Pioneer of Modern Pharmacological Research in China	2

Mechanistic insights into the GEF activity of the human MON1A/CCZ1/C18orf8 complex	2
Follicle stimulating hormone controls granulosa cell glutamine synthesis to regulate ovulation	2
Deciphering the placental abnormalities associated with somatic cell nuclear transfer at single-nucleus resolution	2
In memory of the well-renowned Chinese cellular biologist Shien Sher-Pu	2
Comprehensive transcriptional atlas of human adenomyosis deciphered by the integration of single-cell RNA-sequencing and spatial transcriptomics	2
A CRISPR activation screen identifies genes that enhance SARS-CoV-2 infection	2
Discovery of CCDC188 gene as a novel genetic target for human acephalic spermatozoa syndrome	2
RNA G-quadruplex (rG4) exacerbates cellular senescence by mediating ribosome pausing	2
Professor Delong Su: a pioneer in Schistosomiasis Eradication in China	2